Motif 802 (n=246)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NHR9 | SMCHD1 | S1709 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| H0YC42 | None | S155 | ochoa | Tumor protein D52 | None |
| H7C4K7 | None | S59 | ochoa | Nucleoporin NUP188 | None |
| O00311 | CDC7 | S318 | psp | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O00401 | WASL | S426 | ochoa | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828, ECO:0000269|PubMed:9422512}. |
| O00409 | FOXN3 | S412 | ochoa | Forkhead box protein N3 (Checkpoint suppressor 1) | Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269|PubMed:16102918}. |
| O14578 | CIT | S795 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14744 | PRMT5 | S335 | psp | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
| O14795 | UNC13B | S917 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O43422 | THAP12 | S107 | ochoa | 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12) | Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. |
| O43781 | DYRK3 | S350 | psp | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:29634919, PubMed:9748265). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}. |
| O43815 | STRN | S227 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60238 | BNIP3L | S168 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O60271 | SPAG9 | S597 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60669 | SLC16A7 | S219 | ochoa | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}. |
| O75145 | PPFIA3 | S766 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75417 | POLQ | S925 | ochoa | DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] | Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). {ECO:0000250|UniProtKB:Q8CGS6, ECO:0000269|PubMed:14576298, ECO:0000269|PubMed:18503084, ECO:0000269|PubMed:19188258, ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:22135286, ECO:0000269|PubMed:24648516, ECO:0000269|PubMed:25642963, ECO:0000269|PubMed:25643323, ECO:0000269|PubMed:25775267, ECO:0000269|PubMed:26636256, ECO:0000269|PubMed:27311885, ECO:0000269|PubMed:27591252, ECO:0000269|PubMed:28695890, ECO:0000269|PubMed:30655289, ECO:0000269|PubMed:31562312, ECO:0000269|PubMed:32234782, ECO:0000269|PubMed:32873648, ECO:0000269|PubMed:34117057, ECO:0000269|PubMed:34140467, ECO:0000269|PubMed:34179826, ECO:0000269|PubMed:36455556, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080}. |
| O75473 | LGR5 | S851 | psp | Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}. |
| O75475 | PSIP1 | S62 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75475 | PSIP1 | S482 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75563 | SKAP2 | S131 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O75822 | EIF3J | S72 | ochoa | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O75914 | PAK3 | S50 | psp | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O75943 | RAD17 | S362 | psp | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
| O94804 | STK10 | S516 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94967 | WDR47 | S578 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95218 | ZRANB2 | S65 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O95359 | TACC2 | S2134 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95613 | PCNT | S2044 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95835 | LATS1 | S613 | ochoa|psp | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P00533 | EGFR | S720 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P03372 | ESR1 | S212 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04279 | SEMG1 | S313 | ochoa | Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein] | Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. {ECO:0000269|PubMed:19889947}.; FUNCTION: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. {ECO:0000269|PubMed:19889947}. |
| P04626 | ERBB2 | S728 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P06241 | FYN | S188 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P06400 | RB1 | S866 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P06748 | NPM1 | S242 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P06748 | NPM1 | S254 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07900 | HSP90AA1 | S505 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07947 | YES1 | S197 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P07948 | LYN | S168 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08238 | HSP90AB1 | S497 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09327 | VIL1 | S366 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P09429 | HMGB1 | S35 | ochoa|psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P09543 | CNP | S170 | ochoa | 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) | Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P16330}. |
| P09769 | FGR | S183 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P11055 | MYH3 | S1777 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S1780 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1776 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1778 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1779 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13994 | YJU2B | S238 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
| P16083 | NQO2 | S83 | ochoa | Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) | The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}. |
| P17612 | PRKACA | S54 | ochoa | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P18846 | ATF1 | S72 | ochoa | Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| P19021 | PAM | S942 | ochoa | Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] | Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:12699694, PubMed:2357221). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (PubMed:1575450). C-terminal amidation also takes place in response to protein fragmentation triggered by oxidative stress, promoting degradation of amidated protein fragments by the proteasome (PubMed:2207077). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme (PubMed:12699694). The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:12699694). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:12699694). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity). {ECO:0000250|UniProtKB:P14925, ECO:0000269|PubMed:12699694, ECO:0000269|PubMed:2357221, ECO:0000303|PubMed:1575450, ECO:0000303|PubMed:2207077}. |
| P20810 | CAST | S87 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21796 | VDAC1 | S102 | ochoa|psp | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P21860 | ERBB3 | S717 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P22694 | PRKACB | S54 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P25440 | BRD2 | S744 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P25788 | PSMA3 | S35 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P26358 | DNMT1 | S35 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P26583 | HMGB2 | S35 | ochoa | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}. |
| P27816 | MAP4 | S510 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29323 | EPHB2 | S586 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P29966 | MARCKS | S167 | ochoa|psp | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P33121 | ACSL1 | S620 | ochoa | Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). {ECO:0000250|UniProtKB:P18163, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| P34932 | HSPA4 | S756 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P35367 | HRH1 | S255 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P35637 | FUS | S340 | ochoa | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P36578 | RPL4 | S275 | ochoa | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P36952 | SERPINB5 | S240 | psp | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P37235 | HPCAL1 | S143 | ochoa | Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) (HLP2) (Visinin-like protein 3) (VILIP-3) | May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. |
| P37275 | ZEB1 | S1100 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P38398 | BRCA1 | S1101 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P45973 | CBX5 | S97 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P46013 | MKI67 | S352 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S651 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1136 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1414 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2471 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S692 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S788 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S962 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S582 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48307 | TFPI2 | S168 | ochoa | Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5) | May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. {ECO:0000269|PubMed:7872799}. |
| P49419 | ALDH7A1 | S520 | ochoa | Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) | Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. {ECO:0000269|PubMed:16491085, ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:21338592}. |
| P49790 | NUP153 | S1113 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49796 | RGS3 | S1116 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P51587 | BRCA2 | S581 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P51587 | BRCA2 | S3319 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52179 | MYOM1 | S1399 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54578 | USP14 | S230 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P54920 | NAPA | S159 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P55199 | ELL | S518 | ochoa | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| P60484 | PTEN | S229 | psp | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P60900 | PSMA6 | S177 | ochoa | Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P63165 | SUMO1 | S31 | ochoa | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
| Q00403 | GTF2B | S92 | ochoa | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| Q00577 | PURA | S256 | ochoa | Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) | This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097, PubMed:20976240). May play a role in the initiation of DNA replication and in recombination. {ECO:0000269|PubMed:1448097, ECO:0000269|PubMed:20976240}. |
| Q00872 | MYBPC1 | S906 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q01780 | EXOSC10 | S785 | ochoa | Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250|UniProtKB:P56960, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:25632158, ECO:0000269|PubMed:26857222, ECO:0000269|PubMed:31086179, ECO:0000269|PubMed:32830871, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36912080}. |
| Q01804 | OTUD4 | S893 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q03164 | KMT2A | S261 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q09666 | AHNAK | S5604 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12830 | BPTF | S1310 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12983 | BNIP3 | S144 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q13201 | MMRN1 | S368 | ochoa | Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}. |
| Q13315 | ATM | S85 | ochoa|psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13449 | LSAMP | S204 | ochoa | Limbic system-associated membrane protein (LSAMP) (IgLON family member 3) | Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity). {ECO:0000250}. |
| Q14004 | CDK13 | S525 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14185 | DOCK1 | S1704 | ochoa | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}. |
| Q14318 | FKBP8 | S358 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}. |
| Q14644 | RASA3 | S809 | ochoa | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Q14738 | PPP2R5D | S88 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q14781 | CBX2 | S302 | ochoa | Chromobox protein homolog 2 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). {ECO:0000250|UniProtKB:P30658, ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}. |
| Q14CB8 | ARHGAP19 | S422 | ochoa|psp | Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q15291 | RBBP5 | S497 | ochoa | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:Q8BX09, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| Q15303 | ERBB4 | S726 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q15746 | MYLK | S1570 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16543 | CDC37 | S127 | ochoa|psp | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q16659 | MAPK6 | S555 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q16836 | HADH | S73 | ochoa | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| Q16890 | TPD52L1 | S115 | ochoa | Tumor protein D53 (hD53) (Tumor protein D52-like 1) | None |
| Q53FP2 | TMEM35A | S61 | ochoa | Novel acetylcholine receptor chaperone | Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916). {ECO:0000250|UniProtKB:Q9D328, ECO:0000269|PubMed:26875622, ECO:0000269|PubMed:27789755, ECO:0000269|PubMed:28445721, ECO:0000269|PubMed:32204458, ECO:0000269|PubMed:32676916, ECO:0000269|PubMed:32783947}. |
| Q58FF7 | HSP90AB3P | S370 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5S007 | LRRK2 | S955 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5SRE5 | NUP188 | S57 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5TAX3 | TUT4 | S49 | ochoa | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q5TCX8 | MAP3K21 | S514 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5UIP0 | RIF1 | S2348 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VST9 | OBSCN | S7450 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VU43 | PDE4DIP | S1096 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VUA4 | ZNF318 | S264 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUA4 | ZNF318 | S1238 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VZ89 | DENND4C | S1355 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HN8 | RNF213 | S926 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q66K14 | TBC1D9B | S463 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6IQ55 | TTBK2 | S479 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6PGQ7 | BORA | S112 | psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q70Z53 | FRA10AC1 | S252 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q76I76 | SSH2 | S487 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q7KZI7 | MARK2 | S722 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L4I2 | RSRC2 | S348 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7L8C5 | SYT13 | S58 | ochoa | Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII) | May be involved in transport vesicle docking to the plasma membrane. {ECO:0000250}. |
| Q7Z401 | DENND4A | S939 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z4V5 | HDGFL2 | S458 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z6B7 | SRGAP1 | S819 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86UE4 | MTDH | S295 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86V48 | LUZP1 | S772 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VH4 | LRRTM4 | S461 | ochoa | Leucine-rich repeat transmembrane neuronal protein 4 | May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). {ECO:0000250}. |
| Q86WH2 | RASSF3 | S137 | ochoa | Ras association domain-containing protein 3 | None |
| Q8IUC4 | RHPN2 | S639 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8IX21 | SLF2 | S444 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IXI1 | RHOT2 | S156 | psp | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8IXI2 | RHOT1 | S156 | psp | Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788). Can hydrolyze GTP, ATP and UTP (PubMed:30513825). {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27716788, ECO:0000269|PubMed:30513825}. |
| Q8N8R7 | ARL14EP | S183 | ochoa | ARL14 effector protein (ARF7 effector protein) | Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. {ECO:0000269|PubMed:21458045}. |
| Q8ND04 | SMG8 | S469 | ochoa | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}. |
| Q8NHV4 | NEDD1 | S377 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TDM6 | DLG5 | S941 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDM6 | DLG5 | S972 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEA8 | DTD1 | S182 | psp | D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) | Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}. |
| Q8TF01 | PNISR | S672 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WUA4 | GTF3C2 | S147 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WXW3 | PIBF1 | S700 | ochoa | Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) | Plays a role in ciliogenesis. {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441). {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}. |
| Q8WYP3 | RIN2 | S486 | ochoa | Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2) | Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}. |
| Q92564 | DCUN1D4 | S71 | ochoa | DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4) | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). {ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:26906416}. |
| Q92608 | DOCK2 | S1705 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92731 | ESR2 | S176 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q92736 | RYR2 | S3303 | ochoa | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q92804 | TAF15 | S289 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q92888 | ARHGEF1 | S240 | psp | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q92930 | RAB8B | S182 | ochoa | Ras-related protein Rab-8B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P70550, ECO:0000269|PubMed:32344433, ECO:0000305}. |
| Q96AQ6 | PBXIP1 | S469 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96FQ6 | S100A16 | S27 | ochoa | Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16) | Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). {ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}. |
| Q96FQ6 | S100A16 | S36 | ochoa | Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16) | Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). {ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}. |
| Q96GV9 | MACIR | S167 | ochoa | Macrophage immunometabolism regulator | Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}. |
| Q96MD7 | C9orf85 | S21 | ochoa | Uncharacterized protein C9orf85 | None |
| Q96QC0 | PPP1R10 | S398 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q96RL1 | UIMC1 | S26 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96ST3 | SIN3A | S940 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q96T23 | RSF1 | S392 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99698 | LYST | S2152 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BVI0 | PHF20 | S519 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BXS6 | NUSAP1 | S333 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BYG3 | NIFK | S218 | ochoa | MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) | None |
| Q9BYP7 | WNK3 | S62 | ochoa | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9BYW2 | SETD2 | S905 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZD4 | NUF2 | S247 | ochoa | Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23085020}. |
| Q9H0A0 | NAT10 | S984 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
| Q9H115 | NAPB | S159 | ochoa | Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. {ECO:0000250|UniProtKB:P28663}. |
| Q9H1H9 | KIF13A | S1287 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H1J1 | UPF3A | S170 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9H2G9 | BLZF1 | S59 | ochoa | Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) | Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}. |
| Q9H501 | ESF1 | S823 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H9S0 | NANOG | S79 | psp | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}. |
| Q9HCK8 | CHD8 | S1540 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCM1 | RESF1 | S1208 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
| Q9NPI7 | KRCC1 | S183 | ochoa | Lysine-rich coiled-coil protein 1 (Cryptogenic hepatitis-binding protein 2) | None |
| Q9NTJ3 | SMC4 | S355 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NVN8 | GNL3L | S22 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9NW13 | RBM28 | S200 | ochoa | RNA-binding protein 28 (RNA-binding motif protein 28) | Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
| Q9NW75 | GPATCH2 | S117 | ochoa | G patch domain-containing protein 2 | Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}. |
| Q9NWH9 | SLTM | S533 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NYF8 | BCLAF1 | S573 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P1T7 | MDFIC | S140 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Q9P2D1 | CHD7 | S708 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2F6 | ARHGAP20 | S730 | ochoa | Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UBE0 | SAE1 | S201 | ochoa | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. |
| Q9UBN7 | HDAC6 | S43 | ochoa|psp | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UHF7 | TRPS1 | S369 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UK39 | NOCT | S341 | ochoa | Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) | Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539}. |
| Q9UKL3 | CASP8AP2 | S168 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | S1782 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1780 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULR3 | PPM1H | S112 | ochoa | Protein phosphatase 1H (EC 3.1.3.16) | Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}. |
| Q9ULW0 | TPX2 | S209 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UMZ2 | SYNRG | S817 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPW8 | UNC13A | S993 | ochoa | Protein unc-13 homolog A (Munc13-1) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q4KUS2, ECO:0000250|UniProtKB:Q62768, ECO:0000269|PubMed:23999003}. |
| Q9Y2W1 | THRAP3 | S379 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3E5 | PTRH2 | S87 | psp | Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1) | Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis (PubMed:14660562). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. {ECO:0000269|PubMed:14660562, ECO:0000269|PubMed:15006356}. |
| Q9Y520 | PRRC2C | S21 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y546 | LRRC42 | S385 | ochoa | Leucine-rich repeat-containing protein 42 | None |
| Q9Y623 | MYH4 | S1780 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P07602 | PSAP | S29 | Sugiyama | Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] | Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250|UniProtKB:Q61207, ECO:0000269|PubMed:10383054}.; FUNCTION: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
| O43172 | PRPF4 | S298 | Sugiyama | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| P30084 | ECHS1 | S107 | Sugiyama | Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH) | Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity). {ECO:0000250|UniProtKB:P14604, ECO:0000269|PubMed:25125611, ECO:0000269|PubMed:26251176}. |
| Q9BRS2 | RIOK1 | S130 | Sugiyama | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1) | Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}. |
| P78371 | CCT2 | T242 | Sugiyama | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9Y6W5 | WASF2 | S154 | Sugiyama | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| B6ZGS9 | NR1H4 | S154 | GPS6 | Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) | None |
| Q13574 | DGKZ | S265 | SIGNOR | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095, PubMed:9159104). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095, PubMed:9159104). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:19744926, PubMed:22108654, PubMed:9159104). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q80UP3, ECO:0000269|PubMed:15157668, ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:18004883, ECO:0000269|PubMed:19744926, ECO:0000269|PubMed:22108654, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:23949095, ECO:0000269|PubMed:9159104, ECO:0000305|PubMed:8626588}.; FUNCTION: [Isoform 1]: Regulates RASGRP1 activity. {ECO:0000269|PubMed:11257115}.; FUNCTION: [Isoform 2]: Does not regulate RASGRP1 activity. {ECO:0000269|PubMed:11257115}. |
| Q96RI1 | NR1H4 | S164 | SIGNOR | Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) | Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:12754200, PubMed:15471871, PubMed:17895379). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:10514450, PubMed:15239098, PubMed:16269519). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression (PubMed:12815072, PubMed:19085950). The function also involves the coordinated induction of hepatic KLB/beta-klotho expression (By similarity). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA (PubMed:12806625, PubMed:16946559). Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly (PubMed:12554753, PubMed:12660231, PubMed:15337761). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) (PubMed:11579204). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element (PubMed:11927623, PubMed:21804189). Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) (PubMed:12891557). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3) (By similarity). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:20447400). Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (By similarity). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells (PubMed:21242261). Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 (PubMed:19864602). Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling) (By similarity). {ECO:0000250|UniProtKB:Q60641, ECO:0000250|UniProtKB:Q62735, ECO:0000269|PubMed:10334992, ECO:0000269|PubMed:10334993, ECO:0000269|PubMed:10514450, ECO:0000269|PubMed:11579204, ECO:0000269|PubMed:11927623, ECO:0000269|PubMed:12554753, ECO:0000269|PubMed:12660231, ECO:0000269|PubMed:12718892, ECO:0000269|PubMed:12754200, ECO:0000269|PubMed:12806625, ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:12891557, ECO:0000269|PubMed:14684751, ECO:0000269|PubMed:15239098, ECO:0000269|PubMed:15337761, ECO:0000269|PubMed:15471871, ECO:0000269|PubMed:16269519, ECO:0000269|PubMed:16946559, ECO:0000269|PubMed:17895379, ECO:0000269|PubMed:18621523, ECO:0000269|PubMed:19085950, ECO:0000269|PubMed:19410460, ECO:0000269|PubMed:19586769, ECO:0000269|PubMed:19864602, ECO:0000269|PubMed:20447400, ECO:0000269|PubMed:21242261, ECO:0000269|PubMed:21804189, ECO:0000269|PubMed:23928191, ECO:0000305|PubMed:21383957, ECO:0000305|PubMed:22820415}.; FUNCTION: [Isoform 1]: Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 2]: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA), NR0B2/SHP (inducible by unconjugated CDCA DCA and ACA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 3]: Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 4]: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191, ECO:0000269|PubMed:26888176}. |
| P09917 | ALOX5 | S448 | PSP | Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34) | Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:19022417, PubMed:21233389, PubMed:22516296, PubMed:23246375, PubMed:24282679, PubMed:24893149, PubMed:31664810, PubMed:8615788, PubMed:8631361). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:17114001, PubMed:21206090, PubMed:31664810, PubMed:32404334, PubMed:8615788). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:17114001, ECO:0000269|PubMed:19022417, ECO:0000269|PubMed:21200133, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0000269|PubMed:23246375, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24893149, ECO:0000269|PubMed:31664810, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8615788, ECO:0000269|PubMed:8631361}. |
| Q86UP2 | KTN1 | S156 | Sugiyama | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| P62829 | RPL23 | S115 | Sugiyama | Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P31749 | AKT1 | T146 | Sugiyama | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) | AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960, PubMed:31204173). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960, PubMed:29343641, PubMed:31204173). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915, PubMed:12172553). Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5 (PubMed:31548394, PubMed:33594058). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Part of a positive feedback loop of mTORC2 signaling by mediating phosphorylation of MAPKAP1/SIN1, promoting mTORC2 activation (By similarity). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF1 (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 (PubMed:17726016). Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation (PubMed:20086174). Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (PubMed:19592491). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity (PubMed:10576742). Phosphorylation of BAD stimulates its pro-apoptotic activity (PubMed:10926925). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (PubMed:23431171). Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility (PubMed:20471940). Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation (PubMed:18507042). Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization (PubMed:16982699). These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation (PubMed:16139227). Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (PubMed:20682768). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (PubMed:32322062). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). Acts as a regulator of mitochondrial calcium uptake by mediating phosphorylation of MICU1 in the mitochondrial intermembrane space, impairing MICU1 maturation (PubMed:30504268). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (PubMed:15861136). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (PubMed:31204173). {ECO:0000250|UniProtKB:P31750, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941, ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:17726016, ECO:0000269|PubMed:18507042, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20471940, ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:23431171, ECO:0000269|PubMed:30504268, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:9829964, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}. |
| Q96KB5 | PBK | S298 | Sugiyama | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| P20073 | ANXA7 | S216 | Sugiyama | Annexin A7 (Annexin VII) (Annexin-7) (Synexin) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
| Q8N392 | ARHGAP18 | S156 | SIGNOR | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8IW41 | MAPKAPK5 | S33 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8IY84 | NIM1K | S119 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| P50395 | GDI2 | S270 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| Q9NR50 | EIF2B3 | S260 | Sugiyama | Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q9UKI8 | TLK1 | S226 | Sugiyama | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1227986 | Signaling by ERBB2 | 6.897516e-09 | 8.161 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.967325e-08 | 7.528 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.080058e-07 | 6.967 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.455554e-08 | 7.128 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.017714e-07 | 6.992 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.024711e-07 | 6.694 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.276506e-07 | 6.643 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.428819e-07 | 6.465 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.229102e-07 | 6.374 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.213360e-06 | 5.916 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.653096e-06 | 5.782 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.795879e-06 | 5.746 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.864322e-06 | 5.729 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.923758e-06 | 5.534 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.232322e-06 | 5.373 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.349334e-06 | 5.272 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.656347e-06 | 5.247 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.246731e-06 | 5.204 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 7.834058e-06 | 5.106 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.727376e-06 | 5.112 |
| R-HSA-8848021 | Signaling by PTK6 | 7.727376e-06 | 5.112 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.004019e-05 | 4.998 |
| R-HSA-1640170 | Cell Cycle | 1.205070e-05 | 4.919 |
| R-HSA-194138 | Signaling by VEGF | 1.267291e-05 | 4.897 |
| R-HSA-74160 | Gene expression (Transcription) | 1.418906e-05 | 4.848 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.672054e-05 | 4.777 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.169045e-05 | 4.664 |
| R-HSA-212436 | Generic Transcription Pathway | 3.496722e-05 | 4.456 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.467083e-05 | 4.460 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.965395e-05 | 4.224 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.965395e-05 | 4.224 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.965395e-05 | 4.224 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.965395e-05 | 4.224 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.965395e-05 | 4.224 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.965395e-05 | 4.224 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.965395e-05 | 4.224 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.965395e-05 | 4.224 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.965395e-05 | 4.224 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.965395e-05 | 4.224 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.965395e-05 | 4.224 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 4.725322e-05 | 4.326 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 5.875592e-05 | 4.231 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 5.522798e-05 | 4.258 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.289277e-05 | 4.277 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.433958e-05 | 4.074 |
| R-HSA-389356 | Co-stimulation by CD28 | 8.675114e-05 | 4.062 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.063928e-04 | 3.685 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.215339e-04 | 3.655 |
| R-HSA-1433559 | Regulation of KIT signaling | 3.585373e-04 | 3.445 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.982415e-04 | 3.400 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 4.388434e-04 | 3.358 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 4.523416e-04 | 3.345 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.844950e-04 | 3.315 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.947214e-04 | 3.306 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 5.312142e-04 | 3.275 |
| R-HSA-422475 | Axon guidance | 7.631114e-04 | 3.117 |
| R-HSA-1236394 | Signaling by ERBB4 | 8.422023e-04 | 3.075 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 8.905255e-04 | 3.050 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 8.905255e-04 | 3.050 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.315644e-04 | 3.031 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 9.995941e-04 | 3.000 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 9.995941e-04 | 3.000 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.129747e-03 | 2.947 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.111240e-03 | 2.954 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.143964e-03 | 2.942 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.501799e-03 | 2.823 |
| R-HSA-9675108 | Nervous system development | 1.692040e-03 | 2.772 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.812916e-03 | 2.742 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.168799e-03 | 2.664 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.168799e-03 | 2.664 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.168799e-03 | 2.664 |
| R-HSA-162906 | HIV Infection | 2.113480e-03 | 2.675 |
| R-HSA-210990 | PECAM1 interactions | 2.237896e-03 | 2.650 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.558095e-03 | 2.592 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.558095e-03 | 2.592 |
| R-HSA-9664407 | Parasite infection | 2.558095e-03 | 2.592 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.794493e-03 | 2.554 |
| R-HSA-5683826 | Surfactant metabolism | 2.794493e-03 | 2.554 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.693632e-03 | 2.570 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.755368e-03 | 2.560 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 3.252946e-03 | 2.488 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 3.252946e-03 | 2.488 |
| R-HSA-9675135 | Diseases of DNA repair | 3.278192e-03 | 2.484 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.688450e-03 | 2.433 |
| R-HSA-9658195 | Leishmania infection | 3.811090e-03 | 2.419 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.811090e-03 | 2.419 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.819413e-03 | 2.418 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 3.850366e-03 | 2.414 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.033506e-03 | 2.394 |
| R-HSA-180024 | DARPP-32 events | 4.033506e-03 | 2.394 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.079805e-03 | 2.389 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 4.510414e-03 | 2.346 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 4.510414e-03 | 2.346 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 4.510414e-03 | 2.346 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.445132e-03 | 2.352 |
| R-HSA-391160 | Signal regulatory protein family interactions | 4.510414e-03 | 2.346 |
| R-HSA-8963896 | HDL assembly | 4.510414e-03 | 2.346 |
| R-HSA-70171 | Glycolysis | 4.521201e-03 | 2.345 |
| R-HSA-69481 | G2/M Checkpoints | 4.823711e-03 | 2.317 |
| R-HSA-5688426 | Deubiquitination | 4.933965e-03 | 2.307 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 5.490186e-03 | 2.260 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 5.490186e-03 | 2.260 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.207589e-03 | 2.283 |
| R-HSA-418885 | DCC mediated attractive signaling | 5.234902e-03 | 2.281 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.716218e-03 | 2.243 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.879615e-03 | 2.231 |
| R-HSA-162582 | Signal Transduction | 6.282726e-03 | 2.202 |
| R-HSA-390522 | Striated Muscle Contraction | 6.415936e-03 | 2.193 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.523557e-03 | 2.186 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.523557e-03 | 2.186 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 6.883658e-03 | 2.162 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 7.583824e-03 | 2.120 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 6.883658e-03 | 2.162 |
| R-HSA-9675151 | Disorders of Developmental Biology | 6.883658e-03 | 2.162 |
| R-HSA-68886 | M Phase | 7.477074e-03 | 2.126 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 7.810776e-03 | 2.107 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 7.810776e-03 | 2.107 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.888640e-03 | 2.103 |
| R-HSA-8939211 | ESR-mediated signaling | 7.978383e-03 | 2.098 |
| R-HSA-111933 | Calmodulin induced events | 8.216868e-03 | 2.085 |
| R-HSA-111997 | CaM pathway | 8.216868e-03 | 2.085 |
| R-HSA-8853659 | RET signaling | 8.216868e-03 | 2.085 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 9.531107e-03 | 2.021 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 9.531107e-03 | 2.021 |
| R-HSA-3928664 | Ephrin signaling | 8.808050e-03 | 2.055 |
| R-HSA-163615 | PKA activation | 8.808050e-03 | 2.055 |
| R-HSA-164378 | PKA activation in glucagon signalling | 8.808050e-03 | 2.055 |
| R-HSA-438064 | Post NMDA receptor activation events | 8.690281e-03 | 2.061 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.125978e-03 | 2.040 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 9.876553e-03 | 2.005 |
| R-HSA-912631 | Regulation of signaling by CBL | 9.876553e-03 | 2.005 |
| R-HSA-392517 | Rap1 signalling | 9.876553e-03 | 2.005 |
| R-HSA-373755 | Semaphorin interactions | 1.007301e-02 | 1.997 |
| R-HSA-69541 | Stabilization of p53 | 1.032076e-02 | 1.986 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.192064e-02 | 1.924 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.101723e-02 | 1.958 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.101723e-02 | 1.958 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.101723e-02 | 1.958 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.101723e-02 | 1.958 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.223091e-02 | 1.913 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.223091e-02 | 1.913 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.186507e-02 | 1.926 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.190046e-02 | 1.924 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.144408e-02 | 1.941 |
| R-HSA-5693538 | Homology Directed Repair | 1.108909e-02 | 1.955 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 1.223091e-02 | 1.913 |
| R-HSA-164944 | Nef and signal transduction | 1.192064e-02 | 1.924 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.151683e-02 | 1.939 |
| R-HSA-70326 | Glucose metabolism | 1.067300e-02 | 1.972 |
| R-HSA-3371556 | Cellular response to heat stress | 1.240794e-02 | 1.906 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.250756e-02 | 1.903 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.300703e-02 | 1.886 |
| R-HSA-69275 | G2/M Transition | 1.348298e-02 | 1.870 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.362740e-02 | 1.866 |
| R-HSA-111996 | Ca-dependent events | 1.362740e-02 | 1.866 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.362740e-02 | 1.866 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.365120e-02 | 1.865 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.427048e-02 | 1.846 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.454364e-02 | 1.837 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.454745e-02 | 1.837 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.487995e-02 | 1.827 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 1.537883e-02 | 1.813 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.487995e-02 | 1.827 |
| R-HSA-9012546 | Interleukin-18 signaling | 1.739102e-02 | 1.760 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.767273e-02 | 1.753 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.650321e-02 | 1.782 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.739102e-02 | 1.760 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 1.782795e-02 | 1.749 |
| R-HSA-449147 | Signaling by Interleukins | 1.507788e-02 | 1.822 |
| R-HSA-5687868 | Defective SFTPA2 causes IPF | 1.797040e-02 | 1.745 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.797040e-02 | 1.745 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.799853e-02 | 1.745 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.861618e-02 | 1.730 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.941494e-02 | 1.712 |
| R-HSA-9620244 | Long-term potentiation | 1.941494e-02 | 1.712 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.973265e-02 | 1.705 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.045392e-02 | 1.689 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 2.045392e-02 | 1.689 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.088962e-02 | 1.680 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.088962e-02 | 1.680 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.107753e-02 | 1.676 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.281582e-02 | 1.642 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.281582e-02 | 1.642 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.281582e-02 | 1.642 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.308734e-02 | 1.637 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.329891e-02 | 1.633 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 2.372373e-02 | 1.625 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 2.372373e-02 | 1.625 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.372373e-02 | 1.625 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.392344e-02 | 1.621 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.408295e-02 | 1.618 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.414423e-02 | 1.617 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.462980e-02 | 1.609 |
| R-HSA-6807070 | PTEN Regulation | 2.495544e-02 | 1.603 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.592880e-02 | 1.586 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.648402e-02 | 1.577 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.701313e-02 | 1.568 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.723426e-02 | 1.565 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 3.085082e-02 | 1.511 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.860332e-02 | 1.544 |
| R-HSA-9663891 | Selective autophagy | 3.304681e-02 | 1.481 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.358791e-02 | 1.474 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 3.469205e-02 | 1.460 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 3.469205e-02 | 1.460 |
| R-HSA-9005895 | Pervasive developmental disorders | 3.469205e-02 | 1.460 |
| R-HSA-9697154 | Disorders of Nervous System Development | 3.469205e-02 | 1.460 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.101989e-02 | 1.508 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.474850e-02 | 1.459 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.482977e-02 | 1.458 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.482977e-02 | 1.458 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.557199e-02 | 1.449 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.561895e-02 | 1.448 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.561895e-02 | 1.448 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.561895e-02 | 1.448 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 3.561895e-02 | 1.448 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.561895e-02 | 1.448 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 3.561895e-02 | 1.448 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.561895e-02 | 1.448 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.561895e-02 | 1.448 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.561895e-02 | 1.448 |
| R-HSA-68875 | Mitotic Prophase | 3.683275e-02 | 1.434 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.709369e-02 | 1.431 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.709369e-02 | 1.431 |
| R-HSA-112043 | PLC beta mediated events | 3.802989e-02 | 1.420 |
| R-HSA-1643685 | Disease | 3.857312e-02 | 1.414 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 3.870807e-02 | 1.412 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 3.870807e-02 | 1.412 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 3.870807e-02 | 1.412 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 3.870807e-02 | 1.412 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.899215e-02 | 1.409 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.910386e-02 | 1.408 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.910386e-02 | 1.408 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.943126e-02 | 1.404 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.943126e-02 | 1.404 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.943126e-02 | 1.404 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.943126e-02 | 1.404 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 5.295140e-02 | 1.276 |
| R-HSA-9916720 | Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 | 5.295140e-02 | 1.276 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.688004e-02 | 1.329 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.148309e-02 | 1.382 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.148309e-02 | 1.382 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.890493e-02 | 1.311 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.086749e-02 | 1.294 |
| R-HSA-167172 | Transcription of the HIV genome | 5.086749e-02 | 1.294 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 4.723480e-02 | 1.326 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 4.723480e-02 | 1.326 |
| R-HSA-3371511 | HSF1 activation | 4.432506e-02 | 1.353 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.950615e-02 | 1.305 |
| R-HSA-162587 | HIV Life Cycle | 4.210128e-02 | 1.376 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.432506e-02 | 1.353 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.148309e-02 | 1.382 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.688004e-02 | 1.329 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.973500e-02 | 1.401 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.432506e-02 | 1.353 |
| R-HSA-422356 | Regulation of insulin secretion | 4.995462e-02 | 1.301 |
| R-HSA-112040 | G-protein mediated events | 4.890493e-02 | 1.311 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.220265e-02 | 1.282 |
| R-HSA-163560 | Triglyceride catabolism | 4.432506e-02 | 1.353 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.318655e-02 | 1.274 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.492047e-02 | 1.260 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5.496874e-02 | 1.260 |
| R-HSA-9646399 | Aggrephagy | 5.496874e-02 | 1.260 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.496874e-02 | 1.260 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.496874e-02 | 1.260 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.496874e-02 | 1.260 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 5.637368e-02 | 1.249 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 5.637368e-02 | 1.249 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.701062e-02 | 1.244 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.780359e-02 | 1.238 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.914299e-02 | 1.228 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.914299e-02 | 1.228 |
| R-HSA-111885 | Opioid Signalling | 6.000757e-02 | 1.222 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.000757e-02 | 1.222 |
| R-HSA-167161 | HIV Transcription Initiation | 6.070633e-02 | 1.217 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 6.070633e-02 | 1.217 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 6.070633e-02 | 1.217 |
| R-HSA-9827857 | Specification of primordial germ cells | 6.115565e-02 | 1.214 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.131741e-02 | 1.212 |
| R-HSA-163685 | Integration of energy metabolism | 6.199133e-02 | 1.208 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.272912e-02 | 1.203 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.272912e-02 | 1.203 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.353368e-02 | 1.197 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6.367607e-02 | 1.196 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.549907e-02 | 1.184 |
| R-HSA-380287 | Centrosome maturation | 6.579157e-02 | 1.182 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 6.607062e-02 | 1.180 |
| R-HSA-432142 | Platelet sensitization by LDL | 6.607062e-02 | 1.180 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 6.607062e-02 | 1.180 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 6.607062e-02 | 1.180 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.671186e-02 | 1.176 |
| R-HSA-373752 | Netrin-1 signaling | 6.981273e-02 | 1.156 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 7.111230e-02 | 1.148 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 7.111230e-02 | 1.148 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 7.297769e-02 | 1.137 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 7.297769e-02 | 1.137 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 7.297769e-02 | 1.137 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 7.297769e-02 | 1.137 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.331119e-02 | 1.135 |
| R-HSA-373753 | Nephrin family interactions | 7.627458e-02 | 1.118 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 8.669046e-02 | 1.062 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 8.669046e-02 | 1.062 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 8.669046e-02 | 1.062 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 1.031080e-01 | 0.987 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 9.242660e-02 | 1.034 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 9.801371e-02 | 1.009 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.016136e-01 | 0.993 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.708630e-02 | 1.113 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.708630e-02 | 1.113 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.004772e-01 | 0.998 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.978103e-02 | 1.047 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.978103e-02 | 1.047 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 8.972724e-02 | 1.047 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 9.801371e-02 | 1.009 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 8.669046e-02 | 1.062 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 1.031080e-01 | 0.987 |
| R-HSA-68877 | Mitotic Prometaphase | 9.371267e-02 | 1.028 |
| R-HSA-9612973 | Autophagy | 9.924987e-02 | 1.003 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.211560e-02 | 1.036 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 9.242660e-02 | 1.034 |
| R-HSA-912446 | Meiotic recombination | 9.325448e-02 | 1.030 |
| R-HSA-9729555 | Sensory perception of sour taste | 1.031080e-01 | 0.987 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 8.155153e-02 | 1.089 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.036935e-01 | 0.984 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.769671e-02 | 1.110 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.153107e-01 | 0.938 |
| R-HSA-9634597 | GPER1 signaling | 8.284677e-02 | 1.082 |
| R-HSA-390650 | Histamine receptors | 8.669046e-02 | 1.062 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.181616e-02 | 1.087 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 1.031080e-01 | 0.987 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 9.801371e-02 | 1.009 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 9.801371e-02 | 1.009 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 1.153107e-01 | 0.938 |
| R-HSA-9766229 | Degradation of CDH1 | 8.625763e-02 | 1.064 |
| R-HSA-5617833 | Cilium Assembly | 8.860163e-02 | 1.053 |
| R-HSA-1266738 | Developmental Biology | 1.134707e-01 | 0.945 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.730970e-02 | 1.112 |
| R-HSA-69206 | G1/S Transition | 1.131722e-01 | 0.946 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.389425e-02 | 1.076 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.120318e-02 | 1.090 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.153107e-01 | 0.938 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.027681e-02 | 1.095 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.102587e-01 | 0.958 |
| R-HSA-168249 | Innate Immune System | 1.044954e-01 | 0.981 |
| R-HSA-1500931 | Cell-Cell communication | 8.824983e-02 | 1.054 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 8.693740e-02 | 1.061 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 9.801371e-02 | 1.009 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 8.155153e-02 | 1.089 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.139609e-02 | 1.039 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.155631e-01 | 0.937 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.155631e-01 | 0.937 |
| R-HSA-5357801 | Programmed Cell Death | 1.177065e-01 | 0.929 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 1.192315e-01 | 0.924 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 1.192315e-01 | 0.924 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 1.350661e-01 | 0.869 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 1.350661e-01 | 0.869 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.506170e-01 | 0.822 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.506170e-01 | 0.822 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 1.506170e-01 | 0.822 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.658892e-01 | 0.780 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.658892e-01 | 0.780 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.658892e-01 | 0.780 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.658892e-01 | 0.780 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.658892e-01 | 0.780 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.658892e-01 | 0.780 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.808877e-01 | 0.743 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.808877e-01 | 0.743 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.956175e-01 | 0.709 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 2.100832e-01 | 0.678 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.100832e-01 | 0.678 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.242897e-01 | 0.649 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.242897e-01 | 0.649 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.242897e-01 | 0.649 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.333085e-01 | 0.875 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.394422e-01 | 0.856 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.456358e-01 | 0.837 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.456358e-01 | 0.837 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.518852e-01 | 0.818 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.581866e-01 | 0.801 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.581866e-01 | 0.801 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.645360e-01 | 0.784 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.645360e-01 | 0.784 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.773639e-01 | 0.751 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.034390e-01 | 0.692 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.100261e-01 | 0.678 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.284872e-01 | 0.891 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.753447e-01 | 0.756 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.274002e-01 | 0.895 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.474535e-01 | 0.831 |
| R-HSA-9664873 | Pexophagy | 2.100832e-01 | 0.678 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.284872e-01 | 0.891 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 1.968761e-01 | 0.706 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.753447e-01 | 0.756 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.350661e-01 | 0.869 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.696449e-01 | 0.770 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 1.506170e-01 | 0.822 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.658892e-01 | 0.780 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.808877e-01 | 0.743 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.956175e-01 | 0.709 |
| R-HSA-192905 | vRNP Assembly | 2.242897e-01 | 0.649 |
| R-HSA-4839744 | Signaling by APC mutants | 2.242897e-01 | 0.649 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.456358e-01 | 0.837 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.709296e-01 | 0.767 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.234072e-01 | 0.909 |
| R-HSA-191859 | snRNP Assembly | 1.234072e-01 | 0.909 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.512154e-01 | 0.820 |
| R-HSA-203615 | eNOS activation | 1.709296e-01 | 0.767 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.645360e-01 | 0.784 |
| R-HSA-1632852 | Macroautophagy | 1.616962e-01 | 0.791 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.456594e-01 | 0.837 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.074476e-01 | 0.683 |
| R-HSA-9026403 | Biosynthesis of DPAn-3-derived 13-series resolvins | 1.192315e-01 | 0.924 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 1.506170e-01 | 0.822 |
| R-HSA-164843 | 2-LTR circle formation | 2.100832e-01 | 0.678 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.518852e-01 | 0.818 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.773639e-01 | 0.751 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.773639e-01 | 0.751 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.232610e-01 | 0.651 |
| R-HSA-9909396 | Circadian clock | 1.337796e-01 | 0.874 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.341721e-01 | 0.630 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.764601e-01 | 0.753 |
| R-HSA-4641258 | Degradation of DVL | 1.903405e-01 | 0.720 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.034390e-01 | 0.692 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.232174e-01 | 0.651 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.232174e-01 | 0.651 |
| R-HSA-8866376 | Reelin signalling pathway | 1.192315e-01 | 0.924 |
| R-HSA-199920 | CREB phosphorylation | 1.506170e-01 | 0.822 |
| R-HSA-389542 | NADPH regeneration | 1.506170e-01 | 0.822 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.808877e-01 | 0.743 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 2.100832e-01 | 0.678 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.838353e-01 | 0.736 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.838353e-01 | 0.736 |
| R-HSA-4641257 | Degradation of AXIN | 1.903405e-01 | 0.720 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.903405e-01 | 0.720 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.166344e-01 | 0.664 |
| R-HSA-73894 | DNA Repair | 1.561046e-01 | 0.807 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.212383e-01 | 0.916 |
| R-HSA-8953854 | Metabolism of RNA | 2.139274e-01 | 0.670 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.581866e-01 | 0.801 |
| R-HSA-1474165 | Reproduction | 1.284774e-01 | 0.891 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.242897e-01 | 0.649 |
| R-HSA-9026290 | Biosynthesis of DPAn-3-derived maresins | 2.242897e-01 | 0.649 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.645360e-01 | 0.784 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.709296e-01 | 0.767 |
| R-HSA-169911 | Regulation of Apoptosis | 1.773639e-01 | 0.751 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.838353e-01 | 0.736 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.968761e-01 | 0.706 |
| R-HSA-3371568 | Attenuation phase | 2.100261e-01 | 0.678 |
| R-HSA-6811438 | Intra-Golgi traffic | 2.232610e-01 | 0.651 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.740740e-01 | 0.759 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.740740e-01 | 0.759 |
| R-HSA-195721 | Signaling by WNT | 2.228983e-01 | 0.652 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.314390e-01 | 0.881 |
| R-HSA-397014 | Muscle contraction | 1.318314e-01 | 0.880 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.034390e-01 | 0.692 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.166344e-01 | 0.664 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.166344e-01 | 0.664 |
| R-HSA-2029481 | FCGR activation | 1.192208e-01 | 0.924 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.138493e-01 | 0.670 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.979680e-01 | 0.703 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.043912e-01 | 0.690 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.956175e-01 | 0.709 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.100832e-01 | 0.678 |
| R-HSA-9635465 | Suppression of apoptosis | 2.242897e-01 | 0.649 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 2.242897e-01 | 0.649 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.903405e-01 | 0.720 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.034390e-01 | 0.692 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.365583e-01 | 0.626 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.530844e-01 | 0.815 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.844607e-01 | 0.734 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.333085e-01 | 0.875 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 1.394422e-01 | 0.856 |
| R-HSA-445717 | Aquaporin-mediated transport | 1.314390e-01 | 0.881 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 1.696449e-01 | 0.770 |
| R-HSA-201556 | Signaling by ALK | 2.034390e-01 | 0.692 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.709296e-01 | 0.767 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.100261e-01 | 0.678 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.166344e-01 | 0.664 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.741284e-01 | 0.759 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.875506e-01 | 0.727 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.581866e-01 | 0.801 |
| R-HSA-8978934 | Metabolism of cofactors | 1.740740e-01 | 0.759 |
| R-HSA-8979227 | Triglyceride metabolism | 1.234072e-01 | 0.909 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 2.365583e-01 | 0.626 |
| R-HSA-4086400 | PCP/CE pathway | 2.059175e-01 | 0.686 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.753447e-01 | 0.756 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.921020e-01 | 0.716 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.380444e-01 | 0.860 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.917341e-01 | 0.717 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.380444e-01 | 0.860 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.380444e-01 | 0.860 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.968761e-01 | 0.706 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.478783e-01 | 0.830 |
| R-HSA-397795 | G-protein beta:gamma signalling | 1.581866e-01 | 0.801 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.788951e-01 | 0.747 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.824696e-01 | 0.739 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.956343e-01 | 0.709 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.824696e-01 | 0.739 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.318314e-01 | 0.880 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.648441e-01 | 0.783 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.933321e-01 | 0.714 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.043912e-01 | 0.690 |
| R-HSA-202403 | TCR signaling | 1.824696e-01 | 0.739 |
| R-HSA-5218859 | Regulated Necrosis | 1.608887e-01 | 0.793 |
| R-HSA-9607240 | FLT3 Signaling | 2.166344e-01 | 0.664 |
| R-HSA-109581 | Apoptosis | 2.301196e-01 | 0.638 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.034390e-01 | 0.692 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.382416e-01 | 0.623 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.382416e-01 | 0.623 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.382416e-01 | 0.623 |
| R-HSA-162592 | Integration of provirus | 2.382416e-01 | 0.623 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.382416e-01 | 0.623 |
| R-HSA-202670 | ERKs are inactivated | 2.382416e-01 | 0.623 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.382416e-01 | 0.623 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.382416e-01 | 0.623 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.382416e-01 | 0.623 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 2.382416e-01 | 0.623 |
| R-HSA-428540 | Activation of RAC1 | 2.382416e-01 | 0.623 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 2.382416e-01 | 0.623 |
| R-HSA-1500620 | Meiosis | 2.389491e-01 | 0.622 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.389491e-01 | 0.622 |
| R-HSA-9907900 | Proteasome assembly | 2.432237e-01 | 0.614 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.432237e-01 | 0.614 |
| R-HSA-69236 | G1 Phase | 2.432237e-01 | 0.614 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.432237e-01 | 0.614 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.485516e-01 | 0.605 |
| R-HSA-774815 | Nucleosome assembly | 2.498968e-01 | 0.602 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.498968e-01 | 0.602 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.498968e-01 | 0.602 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.498968e-01 | 0.602 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.498968e-01 | 0.602 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.498968e-01 | 0.602 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.498968e-01 | 0.602 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.498968e-01 | 0.602 |
| R-HSA-9824272 | Somitogenesis | 2.498968e-01 | 0.602 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.500248e-01 | 0.602 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.502821e-01 | 0.602 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.502821e-01 | 0.602 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.502821e-01 | 0.602 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.519433e-01 | 0.599 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.519433e-01 | 0.599 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.519433e-01 | 0.599 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.519433e-01 | 0.599 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.519433e-01 | 0.599 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.519433e-01 | 0.599 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.519433e-01 | 0.599 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.519433e-01 | 0.599 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.519433e-01 | 0.599 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2.519433e-01 | 0.599 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 2.519433e-01 | 0.599 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.519433e-01 | 0.599 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.519433e-01 | 0.599 |
| R-HSA-9026286 | Biosynthesis of DPAn-3-derived protectins and resolvins | 2.519433e-01 | 0.599 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.519433e-01 | 0.599 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.519433e-01 | 0.599 |
| R-HSA-6798695 | Neutrophil degranulation | 2.531123e-01 | 0.597 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.565753e-01 | 0.591 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.565753e-01 | 0.591 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.565753e-01 | 0.591 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.565753e-01 | 0.591 |
| R-HSA-75153 | Apoptotic execution phase | 2.565753e-01 | 0.591 |
| R-HSA-68882 | Mitotic Anaphase | 2.590398e-01 | 0.587 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.602468e-01 | 0.585 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.620642e-01 | 0.582 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.630612e-01 | 0.580 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.632567e-01 | 0.580 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.632567e-01 | 0.580 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.632567e-01 | 0.580 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.653994e-01 | 0.576 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.653994e-01 | 0.576 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.653994e-01 | 0.576 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.653994e-01 | 0.576 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.653994e-01 | 0.576 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.653994e-01 | 0.576 |
| R-HSA-202424 | Downstream TCR signaling | 2.679219e-01 | 0.572 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.704934e-01 | 0.568 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.704934e-01 | 0.568 |
| R-HSA-112316 | Neuronal System | 2.763185e-01 | 0.559 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.786143e-01 | 0.555 |
| R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | 2.786143e-01 | 0.555 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 2.786143e-01 | 0.555 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.786143e-01 | 0.555 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.825628e-01 | 0.549 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.867074e-01 | 0.543 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.899687e-01 | 0.538 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.899687e-01 | 0.538 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.899687e-01 | 0.538 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.899687e-01 | 0.538 |
| R-HSA-168255 | Influenza Infection | 2.912361e-01 | 0.536 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.915923e-01 | 0.535 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.915923e-01 | 0.535 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.915923e-01 | 0.535 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.915923e-01 | 0.535 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.915923e-01 | 0.535 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.915923e-01 | 0.535 |
| R-HSA-9823739 | Formation of the anterior neural plate | 2.915923e-01 | 0.535 |
| R-HSA-109582 | Hemostasis | 2.943864e-01 | 0.531 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.966329e-01 | 0.528 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.966329e-01 | 0.528 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.966329e-01 | 0.528 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.966329e-01 | 0.528 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.966329e-01 | 0.528 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 2.972718e-01 | 0.527 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.972718e-01 | 0.527 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.032877e-01 | 0.518 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.032877e-01 | 0.518 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.043376e-01 | 0.517 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.043376e-01 | 0.517 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.043376e-01 | 0.517 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.043376e-01 | 0.517 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 3.043376e-01 | 0.517 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 3.043376e-01 | 0.517 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 3.043376e-01 | 0.517 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.061755e-01 | 0.514 |
| R-HSA-72312 | rRNA processing | 3.084098e-01 | 0.511 |
| R-HSA-72649 | Translation initiation complex formation | 3.099314e-01 | 0.509 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.099314e-01 | 0.509 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.102281e-01 | 0.508 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.120244e-01 | 0.506 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.147031e-01 | 0.502 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.165621e-01 | 0.500 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 3.168543e-01 | 0.499 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 3.168543e-01 | 0.499 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 3.168543e-01 | 0.499 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.231782e-01 | 0.491 |
| R-HSA-5578775 | Ion homeostasis | 3.231782e-01 | 0.491 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.231782e-01 | 0.491 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.231782e-01 | 0.491 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 3.291466e-01 | 0.483 |
| R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | 3.291466e-01 | 0.483 |
| R-HSA-2028269 | Signaling by Hippo | 3.291466e-01 | 0.483 |
| R-HSA-6798163 | Choline catabolism | 3.291466e-01 | 0.483 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 3.291466e-01 | 0.483 |
| R-HSA-5621480 | Dectin-2 family | 3.297780e-01 | 0.482 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.305600e-01 | 0.481 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.363601e-01 | 0.473 |
| R-HSA-180292 | GAB1 signalosome | 3.412184e-01 | 0.467 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.412184e-01 | 0.467 |
| R-HSA-2142700 | Biosynthesis of Lipoxins (LX) | 3.412184e-01 | 0.467 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.412184e-01 | 0.467 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 3.412184e-01 | 0.467 |
| R-HSA-351202 | Metabolism of polyamines | 3.494651e-01 | 0.457 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.512353e-01 | 0.454 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.530738e-01 | 0.452 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.530738e-01 | 0.452 |
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | 3.530738e-01 | 0.452 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.530738e-01 | 0.452 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.530738e-01 | 0.452 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.530738e-01 | 0.452 |
| R-HSA-69242 | S Phase | 3.550457e-01 | 0.450 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.559851e-01 | 0.449 |
| R-HSA-450294 | MAP kinase activation | 3.559851e-01 | 0.449 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.559851e-01 | 0.449 |
| R-HSA-9758941 | Gastrulation | 3.591293e-01 | 0.445 |
| R-HSA-4839726 | Chromatin organization | 3.624313e-01 | 0.441 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.624818e-01 | 0.441 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.624818e-01 | 0.441 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.624818e-01 | 0.441 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.647165e-01 | 0.438 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 3.647165e-01 | 0.438 |
| R-HSA-445144 | Signal transduction by L1 | 3.647165e-01 | 0.438 |
| R-HSA-211000 | Gene Silencing by RNA | 3.661227e-01 | 0.436 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.672948e-01 | 0.435 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.710179e-01 | 0.431 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.759062e-01 | 0.425 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.761504e-01 | 0.425 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.761504e-01 | 0.425 |
| R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | 3.761504e-01 | 0.425 |
| R-HSA-198753 | ERK/MAPK targets | 3.761504e-01 | 0.425 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.761504e-01 | 0.425 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.795321e-01 | 0.421 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.818191e-01 | 0.418 |
| R-HSA-5663205 | Infectious disease | 3.823565e-01 | 0.418 |
| R-HSA-1989781 | PPARA activates gene expression | 3.836066e-01 | 0.416 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.873792e-01 | 0.412 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.873792e-01 | 0.412 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.873792e-01 | 0.412 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.873792e-01 | 0.412 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.873792e-01 | 0.412 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.882101e-01 | 0.411 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.905228e-01 | 0.408 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.958104e-01 | 0.403 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.984066e-01 | 0.400 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.984066e-01 | 0.400 |
| R-HSA-9018676 | Biosynthesis of D-series resolvins | 3.984066e-01 | 0.400 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.984066e-01 | 0.400 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.984066e-01 | 0.400 |
| R-HSA-392499 | Metabolism of proteins | 4.002545e-01 | 0.398 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.009036e-01 | 0.397 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.072040e-01 | 0.390 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.092361e-01 | 0.388 |
| R-HSA-200425 | Carnitine shuttle | 4.092361e-01 | 0.388 |
| R-HSA-9018682 | Biosynthesis of maresins | 4.092361e-01 | 0.388 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.092361e-01 | 0.388 |
| R-HSA-3000170 | Syndecan interactions | 4.092361e-01 | 0.388 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.134723e-01 | 0.384 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.134723e-01 | 0.384 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.134723e-01 | 0.384 |
| R-HSA-448424 | Interleukin-17 signaling | 4.134723e-01 | 0.384 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.197077e-01 | 0.377 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.197077e-01 | 0.377 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.198713e-01 | 0.377 |
| R-HSA-429947 | Deadenylation of mRNA | 4.198713e-01 | 0.377 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.198713e-01 | 0.377 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.198713e-01 | 0.377 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.198713e-01 | 0.377 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.200939e-01 | 0.377 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.205084e-01 | 0.376 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.259092e-01 | 0.371 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.259092e-01 | 0.371 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.259092e-01 | 0.371 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.303158e-01 | 0.366 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.303158e-01 | 0.366 |
| R-HSA-9027604 | Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives | 4.303158e-01 | 0.366 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.303158e-01 | 0.366 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.320761e-01 | 0.364 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.320761e-01 | 0.364 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.320761e-01 | 0.364 |
| R-HSA-418990 | Adherens junctions interactions | 4.330503e-01 | 0.363 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.405728e-01 | 0.356 |
| R-HSA-525793 | Myogenesis | 4.405728e-01 | 0.356 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 4.405728e-01 | 0.356 |
| R-HSA-2046105 | Linoleic acid (LA) metabolism | 4.405728e-01 | 0.356 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 4.405728e-01 | 0.356 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 4.405728e-01 | 0.356 |
| R-HSA-73886 | Chromosome Maintenance | 4.432663e-01 | 0.353 |
| R-HSA-8951664 | Neddylation | 4.436140e-01 | 0.353 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.443031e-01 | 0.352 |
| R-HSA-5689603 | UCH proteinases | 4.503617e-01 | 0.346 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.506458e-01 | 0.346 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.506458e-01 | 0.346 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.506458e-01 | 0.346 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.506458e-01 | 0.346 |
| R-HSA-9025094 | Biosynthesis of DPAn-3 SPMs | 4.506458e-01 | 0.346 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.506458e-01 | 0.346 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.506458e-01 | 0.346 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 4.506458e-01 | 0.346 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.551809e-01 | 0.342 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.560601e-01 | 0.341 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.605380e-01 | 0.337 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.605380e-01 | 0.337 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.605380e-01 | 0.337 |
| R-HSA-622312 | Inflammasomes | 4.605380e-01 | 0.337 |
| R-HSA-5620971 | Pyroptosis | 4.605380e-01 | 0.337 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.623660e-01 | 0.335 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 4.623660e-01 | 0.335 |
| R-HSA-5619084 | ABC transporter disorders | 4.623660e-01 | 0.335 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.680680e-01 | 0.330 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.702526e-01 | 0.328 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.702526e-01 | 0.328 |
| R-HSA-5334118 | DNA methylation | 4.702526e-01 | 0.328 |
| R-HSA-9018679 | Biosynthesis of EPA-derived SPMs | 4.702526e-01 | 0.328 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 4.702526e-01 | 0.328 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.742159e-01 | 0.324 |
| R-HSA-9833482 | PKR-mediated signaling | 4.742159e-01 | 0.324 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.797930e-01 | 0.319 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.797930e-01 | 0.319 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.797930e-01 | 0.319 |
| R-HSA-2424491 | DAP12 signaling | 4.797930e-01 | 0.319 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.797930e-01 | 0.319 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.859070e-01 | 0.313 |
| R-HSA-597592 | Post-translational protein modification | 4.871318e-01 | 0.312 |
| R-HSA-2559583 | Cellular Senescence | 4.873954e-01 | 0.312 |
| R-HSA-182971 | EGFR downregulation | 4.891621e-01 | 0.311 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.891621e-01 | 0.311 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.891621e-01 | 0.311 |
| R-HSA-9018683 | Biosynthesis of DPA-derived SPMs | 4.891621e-01 | 0.311 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.891621e-01 | 0.311 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.916918e-01 | 0.308 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.983630e-01 | 0.302 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.045779e-01 | 0.297 |
| R-HSA-9930044 | Nuclear RNA decay | 5.073987e-01 | 0.295 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.073987e-01 | 0.295 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.073987e-01 | 0.295 |
| R-HSA-159418 | Recycling of bile acids and salts | 5.073987e-01 | 0.295 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.073987e-01 | 0.295 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.073987e-01 | 0.295 |
| R-HSA-354192 | Integrin signaling | 5.073987e-01 | 0.295 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.073987e-01 | 0.295 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.076290e-01 | 0.294 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.087984e-01 | 0.293 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.087984e-01 | 0.293 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.087984e-01 | 0.293 |
| R-HSA-157118 | Signaling by NOTCH | 5.091708e-01 | 0.293 |
| R-HSA-9824446 | Viral Infection Pathways | 5.157409e-01 | 0.288 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 5.162723e-01 | 0.287 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.199926e-01 | 0.284 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 5.249865e-01 | 0.280 |
| R-HSA-5205647 | Mitophagy | 5.249865e-01 | 0.280 |
| R-HSA-5673000 | RAF activation | 5.249865e-01 | 0.280 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.253070e-01 | 0.280 |
| R-HSA-156902 | Peptide chain elongation | 5.255257e-01 | 0.279 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.255257e-01 | 0.279 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.335443e-01 | 0.273 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.364626e-01 | 0.270 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.418659e-01 | 0.266 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.419484e-01 | 0.266 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.419484e-01 | 0.266 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.419484e-01 | 0.266 |
| R-HSA-421270 | Cell-cell junction organization | 5.456946e-01 | 0.263 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.472254e-01 | 0.262 |
| R-HSA-71064 | Lysine catabolism | 5.502016e-01 | 0.259 |
| R-HSA-391251 | Protein folding | 5.525411e-01 | 0.258 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.525411e-01 | 0.258 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.578128e-01 | 0.254 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.578128e-01 | 0.254 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 5.583066e-01 | 0.253 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.621894e-01 | 0.250 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.630402e-01 | 0.249 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.637670e-01 | 0.249 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.662661e-01 | 0.247 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.682234e-01 | 0.245 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.728950e-01 | 0.242 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.733622e-01 | 0.242 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.740826e-01 | 0.241 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.740826e-01 | 0.241 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.740826e-01 | 0.241 |
| R-HSA-167169 | HIV Transcription Elongation | 5.740826e-01 | 0.241 |
| R-HSA-5260271 | Diseases of Immune System | 5.740826e-01 | 0.241 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.740826e-01 | 0.241 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.740826e-01 | 0.241 |
| R-HSA-202433 | Generation of second messenger molecules | 5.740826e-01 | 0.241 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.784565e-01 | 0.238 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.784565e-01 | 0.238 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.784565e-01 | 0.238 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.784565e-01 | 0.238 |
| R-HSA-166520 | Signaling by NTRKs | 5.802428e-01 | 0.236 |
| R-HSA-388396 | GPCR downstream signalling | 5.825950e-01 | 0.235 |
| R-HSA-416476 | G alpha (q) signalling events | 5.871356e-01 | 0.231 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 5.892969e-01 | 0.230 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.892969e-01 | 0.230 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.892969e-01 | 0.230 |
| R-HSA-3214847 | HATs acetylate histones | 5.934718e-01 | 0.227 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.934718e-01 | 0.227 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.934718e-01 | 0.227 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.966997e-01 | 0.224 |
| R-HSA-165159 | MTOR signalling | 5.966997e-01 | 0.224 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.983877e-01 | 0.223 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.983877e-01 | 0.223 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.994696e-01 | 0.222 |
| R-HSA-69306 | DNA Replication | 6.002795e-01 | 0.222 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.032589e-01 | 0.219 |
| R-HSA-9710421 | Defective pyroptosis | 6.039696e-01 | 0.219 |
| R-HSA-8854214 | TBC/RABGAPs | 6.039696e-01 | 0.219 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 6.039696e-01 | 0.219 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.080854e-01 | 0.216 |
| R-HSA-1483255 | PI Metabolism | 6.080854e-01 | 0.216 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.111088e-01 | 0.214 |
| R-HSA-2172127 | DAP12 interactions | 6.111088e-01 | 0.214 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 6.111088e-01 | 0.214 |
| R-HSA-375280 | Amine ligand-binding receptors | 6.111088e-01 | 0.214 |
| R-HSA-192823 | Viral mRNA Translation | 6.128674e-01 | 0.213 |
| R-HSA-2262752 | Cellular responses to stress | 6.131800e-01 | 0.212 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.176048e-01 | 0.209 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.181198e-01 | 0.209 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.250048e-01 | 0.204 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.250048e-01 | 0.204 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.250048e-01 | 0.204 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.269460e-01 | 0.203 |
| R-HSA-446728 | Cell junction organization | 6.293810e-01 | 0.201 |
| R-HSA-418346 | Platelet homeostasis | 6.315500e-01 | 0.200 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 6.317660e-01 | 0.199 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.361097e-01 | 0.196 |
| R-HSA-69239 | Synthesis of DNA | 6.361097e-01 | 0.196 |
| R-HSA-9031628 | NGF-stimulated transcription | 6.384058e-01 | 0.195 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.406252e-01 | 0.193 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.449263e-01 | 0.190 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.450967e-01 | 0.190 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 6.576178e-01 | 0.182 |
| R-HSA-2514856 | The phototransduction cascade | 6.576178e-01 | 0.182 |
| R-HSA-418594 | G alpha (i) signalling events | 6.596494e-01 | 0.181 |
| R-HSA-8978868 | Fatty acid metabolism | 6.596494e-01 | 0.181 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.637929e-01 | 0.178 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.637929e-01 | 0.178 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.698571e-01 | 0.174 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.698571e-01 | 0.174 |
| R-HSA-1221632 | Meiotic synapsis | 6.698571e-01 | 0.174 |
| R-HSA-445355 | Smooth Muscle Contraction | 6.698571e-01 | 0.174 |
| R-HSA-418555 | G alpha (s) signalling events | 6.705444e-01 | 0.174 |
| R-HSA-199991 | Membrane Trafficking | 6.710189e-01 | 0.173 |
| R-HSA-418597 | G alpha (z) signalling events | 6.816603e-01 | 0.166 |
| R-HSA-9012852 | Signaling by NOTCH3 | 6.816603e-01 | 0.166 |
| R-HSA-168256 | Immune System | 6.819686e-01 | 0.166 |
| R-HSA-373760 | L1CAM interactions | 6.833787e-01 | 0.165 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.841305e-01 | 0.165 |
| R-HSA-177929 | Signaling by EGFR | 6.874033e-01 | 0.163 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.874033e-01 | 0.163 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.930430e-01 | 0.159 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.985813e-01 | 0.156 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.985813e-01 | 0.156 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.031517e-01 | 0.153 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.031517e-01 | 0.153 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 7.040200e-01 | 0.152 |
| R-HSA-186712 | Regulation of beta-cell development | 7.040200e-01 | 0.152 |
| R-HSA-8873719 | RAB geranylgeranylation | 7.093609e-01 | 0.149 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.093609e-01 | 0.149 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.093609e-01 | 0.149 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.093609e-01 | 0.149 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.093609e-01 | 0.149 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.093609e-01 | 0.149 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.093609e-01 | 0.149 |
| R-HSA-72766 | Translation | 7.093618e-01 | 0.149 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.107695e-01 | 0.148 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.143270e-01 | 0.146 |
| R-HSA-211976 | Endogenous sterols | 7.146058e-01 | 0.146 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.197563e-01 | 0.143 |
| R-HSA-1268020 | Mitochondrial protein import | 7.197563e-01 | 0.143 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 7.197563e-01 | 0.143 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.197563e-01 | 0.143 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.248142e-01 | 0.140 |
| R-HSA-372790 | Signaling by GPCR | 7.257955e-01 | 0.139 |
| R-HSA-114608 | Platelet degranulation | 7.291020e-01 | 0.137 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.297811e-01 | 0.137 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.297811e-01 | 0.137 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.326484e-01 | 0.135 |
| R-HSA-1280218 | Adaptive Immune System | 7.425077e-01 | 0.129 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 7.441521e-01 | 0.128 |
| R-HSA-5576891 | Cardiac conduction | 7.464426e-01 | 0.127 |
| R-HSA-9609690 | HCMV Early Events | 7.486312e-01 | 0.126 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.497946e-01 | 0.125 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 7.577613e-01 | 0.120 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.577613e-01 | 0.120 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.616027e-01 | 0.118 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.621354e-01 | 0.118 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.621354e-01 | 0.118 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.706489e-01 | 0.113 |
| R-HSA-4086398 | Ca2+ pathway | 7.706489e-01 | 0.113 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.788587e-01 | 0.109 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.788587e-01 | 0.109 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.788587e-01 | 0.109 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.828531e-01 | 0.106 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.828531e-01 | 0.106 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.867756e-01 | 0.104 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.900113e-01 | 0.102 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.906275e-01 | 0.102 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.919453e-01 | 0.101 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.011897e-01 | 0.096 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 8.017719e-01 | 0.096 |
| R-HSA-977225 | Amyloid fiber formation | 8.017719e-01 | 0.096 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.088712e-01 | 0.092 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.092250e-01 | 0.092 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.123252e-01 | 0.090 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.144203e-01 | 0.089 |
| R-HSA-73887 | Death Receptor Signaling | 8.194892e-01 | 0.086 |
| R-HSA-9679506 | SARS-CoV Infections | 8.220987e-01 | 0.085 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.243663e-01 | 0.084 |
| R-HSA-70268 | Pyruvate metabolism | 8.255302e-01 | 0.083 |
| R-HSA-9610379 | HCMV Late Events | 8.268607e-01 | 0.083 |
| R-HSA-9711097 | Cellular response to starvation | 8.292572e-01 | 0.081 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.430201e-01 | 0.074 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.436215e-01 | 0.074 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.458525e-01 | 0.073 |
| R-HSA-5619102 | SLC transporter disorders | 8.495184e-01 | 0.071 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 8.572606e-01 | 0.067 |
| R-HSA-72306 | tRNA processing | 8.578031e-01 | 0.067 |
| R-HSA-157579 | Telomere Maintenance | 8.598427e-01 | 0.066 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.623782e-01 | 0.064 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.648680e-01 | 0.063 |
| R-HSA-9609646 | HCMV Infection | 8.684940e-01 | 0.061 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.720713e-01 | 0.059 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.766596e-01 | 0.057 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 8.788919e-01 | 0.056 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 8.788919e-01 | 0.056 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 8.788919e-01 | 0.056 |
| R-HSA-9833110 | RSV-host interactions | 8.788919e-01 | 0.056 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.832364e-01 | 0.054 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.914649e-01 | 0.050 |
| R-HSA-983712 | Ion channel transport | 8.917480e-01 | 0.050 |
| R-HSA-6803157 | Antimicrobial peptides | 8.934301e-01 | 0.049 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.953598e-01 | 0.048 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.993431e-01 | 0.046 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 9.009424e-01 | 0.045 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.044983e-01 | 0.044 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.075610e-01 | 0.042 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.078027e-01 | 0.042 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.104720e-01 | 0.041 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.121946e-01 | 0.040 |
| R-HSA-72172 | mRNA Splicing | 9.143408e-01 | 0.039 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.144206e-01 | 0.039 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 9.174941e-01 | 0.037 |
| R-HSA-1483257 | Phospholipid metabolism | 9.258364e-01 | 0.033 |
| R-HSA-9843745 | Adipogenesis | 9.312880e-01 | 0.031 |
| R-HSA-9717189 | Sensory perception of taste | 9.312880e-01 | 0.031 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 9.325341e-01 | 0.030 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.360605e-01 | 0.029 |
| R-HSA-913531 | Interferon Signaling | 9.360605e-01 | 0.029 |
| R-HSA-5173105 | O-linked glycosylation | 9.395514e-01 | 0.027 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.468240e-01 | 0.024 |
| R-HSA-2187338 | Visual phototransduction | 9.505812e-01 | 0.022 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.532243e-01 | 0.021 |
| R-HSA-2142753 | Arachidonate metabolism | 9.549077e-01 | 0.020 |
| R-HSA-9609507 | Protein localization | 9.557265e-01 | 0.020 |
| R-HSA-877300 | Interferon gamma signaling | 9.603379e-01 | 0.018 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.657502e-01 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.708807e-01 | 0.013 |
| R-HSA-382551 | Transport of small molecules | 9.755600e-01 | 0.011 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.758089e-01 | 0.011 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.762740e-01 | 0.010 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.801071e-01 | 0.009 |
| R-HSA-428157 | Sphingolipid metabolism | 9.819899e-01 | 0.008 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.826401e-01 | 0.008 |
| R-HSA-1474244 | Extracellular matrix organization | 9.879584e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.883362e-01 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 9.895396e-01 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.897438e-01 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.957373e-01 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.959423e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.972317e-01 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.973144e-01 | 0.001 |
| R-HSA-8957322 | Metabolism of steroids | 9.981737e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.998417e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.888 | 0.178 | 2 | 0.900 |
CLK3 |
0.883 | 0.298 | 1 | 0.843 |
PIM3 |
0.878 | 0.160 | -3 | 0.860 |
NDR2 |
0.877 | 0.129 | -3 | 0.860 |
NLK |
0.876 | 0.156 | 1 | 0.862 |
CDC7 |
0.875 | 0.004 | 1 | 0.820 |
NDR1 |
0.875 | 0.175 | -3 | 0.858 |
CDKL1 |
0.875 | 0.151 | -3 | 0.834 |
CAMK1B |
0.875 | 0.129 | -3 | 0.893 |
CDKL5 |
0.874 | 0.193 | -3 | 0.824 |
MOS |
0.874 | 0.064 | 1 | 0.856 |
ERK5 |
0.874 | 0.202 | 1 | 0.879 |
PRPK |
0.874 | -0.080 | -1 | 0.857 |
PKN3 |
0.873 | 0.135 | -3 | 0.860 |
DSTYK |
0.873 | 0.056 | 2 | 0.920 |
TBK1 |
0.872 | -0.000 | 1 | 0.782 |
MST4 |
0.872 | 0.176 | 2 | 0.871 |
WNK1 |
0.872 | 0.149 | -2 | 0.831 |
RAF1 |
0.872 | -0.018 | 1 | 0.853 |
RSK2 |
0.871 | 0.179 | -3 | 0.805 |
RIPK3 |
0.870 | 0.076 | 3 | 0.780 |
PIM1 |
0.870 | 0.212 | -3 | 0.814 |
MTOR |
0.870 | -0.064 | 1 | 0.812 |
RSK3 |
0.869 | 0.160 | -3 | 0.804 |
PKCD |
0.869 | 0.195 | 2 | 0.831 |
AURC |
0.869 | 0.215 | -2 | 0.698 |
SKMLCK |
0.869 | 0.155 | -2 | 0.836 |
NUAK2 |
0.869 | 0.107 | -3 | 0.872 |
AMPKA1 |
0.869 | 0.153 | -3 | 0.880 |
CAMLCK |
0.869 | 0.144 | -2 | 0.833 |
SRPK1 |
0.869 | 0.169 | -3 | 0.784 |
PKACG |
0.868 | 0.184 | -2 | 0.756 |
GCN2 |
0.868 | -0.140 | 2 | 0.846 |
PRKD2 |
0.868 | 0.158 | -3 | 0.808 |
ULK2 |
0.868 | -0.083 | 2 | 0.837 |
PRKD1 |
0.867 | 0.092 | -3 | 0.844 |
P70S6KB |
0.867 | 0.169 | -3 | 0.832 |
NIK |
0.867 | 0.114 | -3 | 0.905 |
TGFBR2 |
0.867 | 0.023 | -2 | 0.778 |
P90RSK |
0.867 | 0.132 | -3 | 0.805 |
BMPR2 |
0.867 | -0.103 | -2 | 0.844 |
ICK |
0.867 | 0.157 | -3 | 0.863 |
CAMK2G |
0.867 | -0.015 | 2 | 0.867 |
ATR |
0.867 | 0.002 | 1 | 0.836 |
IKKB |
0.866 | -0.095 | -2 | 0.687 |
PDHK4 |
0.866 | -0.255 | 1 | 0.860 |
PKN2 |
0.866 | 0.126 | -3 | 0.865 |
IKKE |
0.865 | -0.062 | 1 | 0.776 |
MARK4 |
0.865 | 0.084 | 4 | 0.886 |
NEK6 |
0.864 | -0.018 | -2 | 0.815 |
HIPK4 |
0.864 | 0.094 | 1 | 0.806 |
HUNK |
0.863 | -0.015 | 2 | 0.842 |
LATS2 |
0.863 | 0.074 | -5 | 0.771 |
DAPK2 |
0.863 | 0.090 | -3 | 0.893 |
WNK3 |
0.863 | -0.058 | 1 | 0.828 |
PDHK1 |
0.863 | -0.185 | 1 | 0.865 |
AMPKA2 |
0.863 | 0.134 | -3 | 0.851 |
KIS |
0.863 | 0.104 | 1 | 0.757 |
TSSK1 |
0.862 | 0.134 | -3 | 0.896 |
SRPK2 |
0.861 | 0.157 | -3 | 0.712 |
NEK7 |
0.861 | -0.107 | -3 | 0.845 |
AURB |
0.861 | 0.176 | -2 | 0.688 |
NIM1 |
0.861 | 0.055 | 3 | 0.804 |
MNK2 |
0.861 | 0.158 | -2 | 0.786 |
TSSK2 |
0.861 | 0.089 | -5 | 0.792 |
MLK1 |
0.860 | -0.059 | 2 | 0.851 |
RSK4 |
0.860 | 0.196 | -3 | 0.771 |
CHAK2 |
0.860 | 0.017 | -1 | 0.876 |
BCKDK |
0.860 | -0.083 | -1 | 0.830 |
PKG2 |
0.860 | 0.202 | -2 | 0.714 |
PAK1 |
0.859 | 0.124 | -2 | 0.774 |
CLK1 |
0.859 | 0.212 | -3 | 0.786 |
CAMK2D |
0.859 | 0.033 | -3 | 0.871 |
PKACB |
0.858 | 0.209 | -2 | 0.706 |
PRKD3 |
0.858 | 0.122 | -3 | 0.785 |
PAK3 |
0.858 | 0.096 | -2 | 0.764 |
SGK3 |
0.858 | 0.206 | -3 | 0.796 |
GRK1 |
0.858 | 0.058 | -2 | 0.760 |
FAM20C |
0.857 | 0.195 | 2 | 0.709 |
NUAK1 |
0.857 | 0.073 | -3 | 0.831 |
CLK4 |
0.857 | 0.186 | -3 | 0.801 |
ULK1 |
0.857 | -0.144 | -3 | 0.829 |
MAPKAPK3 |
0.857 | 0.038 | -3 | 0.810 |
PAK6 |
0.857 | 0.173 | -2 | 0.698 |
SRPK3 |
0.856 | 0.115 | -3 | 0.759 |
PKCA |
0.856 | 0.130 | 2 | 0.771 |
MELK |
0.856 | 0.098 | -3 | 0.838 |
IKKA |
0.856 | -0.035 | -2 | 0.679 |
IRE1 |
0.855 | -0.009 | 1 | 0.787 |
RIPK1 |
0.855 | -0.082 | 1 | 0.818 |
ANKRD3 |
0.855 | -0.054 | 1 | 0.880 |
LATS1 |
0.855 | 0.129 | -3 | 0.864 |
CAMK4 |
0.855 | 0.032 | -3 | 0.852 |
NEK9 |
0.855 | -0.089 | 2 | 0.874 |
CDK8 |
0.855 | 0.069 | 1 | 0.715 |
PRKX |
0.854 | 0.235 | -3 | 0.715 |
MYLK4 |
0.854 | 0.129 | -2 | 0.770 |
CDK7 |
0.854 | 0.088 | 1 | 0.723 |
ATM |
0.854 | 0.011 | 1 | 0.777 |
PKCG |
0.854 | 0.101 | 2 | 0.775 |
PKR |
0.854 | 0.098 | 1 | 0.840 |
PKCB |
0.854 | 0.110 | 2 | 0.778 |
MSK2 |
0.854 | 0.072 | -3 | 0.772 |
GRK5 |
0.853 | -0.207 | -3 | 0.865 |
QSK |
0.853 | 0.087 | 4 | 0.867 |
AKT2 |
0.853 | 0.171 | -3 | 0.731 |
GRK6 |
0.853 | -0.052 | 1 | 0.820 |
PHKG1 |
0.853 | 0.052 | -3 | 0.853 |
MNK1 |
0.853 | 0.143 | -2 | 0.804 |
PIM2 |
0.852 | 0.185 | -3 | 0.786 |
CDK5 |
0.852 | 0.149 | 1 | 0.736 |
QIK |
0.852 | 0.016 | -3 | 0.864 |
MSK1 |
0.852 | 0.124 | -3 | 0.780 |
IRE2 |
0.851 | 0.009 | 2 | 0.790 |
DYRK2 |
0.851 | 0.106 | 1 | 0.743 |
MASTL |
0.851 | -0.275 | -2 | 0.747 |
CAMK2B |
0.851 | 0.076 | 2 | 0.845 |
P38A |
0.851 | 0.139 | 1 | 0.772 |
PKCH |
0.850 | 0.088 | 2 | 0.769 |
SIK |
0.850 | 0.083 | -3 | 0.800 |
TTBK2 |
0.850 | -0.140 | 2 | 0.750 |
PAK2 |
0.850 | 0.070 | -2 | 0.753 |
MLK2 |
0.850 | -0.102 | 2 | 0.865 |
JNK2 |
0.850 | 0.148 | 1 | 0.677 |
CDK19 |
0.849 | 0.071 | 1 | 0.679 |
BMPR1B |
0.849 | 0.060 | 1 | 0.759 |
MAPKAPK2 |
0.849 | 0.058 | -3 | 0.764 |
DLK |
0.849 | -0.167 | 1 | 0.831 |
HIPK1 |
0.849 | 0.161 | 1 | 0.755 |
ALK4 |
0.849 | -0.034 | -2 | 0.791 |
BRSK2 |
0.849 | 0.028 | -3 | 0.852 |
BRSK1 |
0.849 | 0.049 | -3 | 0.829 |
MLK3 |
0.849 | -0.007 | 2 | 0.785 |
PLK1 |
0.848 | -0.033 | -2 | 0.782 |
PKCZ |
0.848 | 0.055 | 2 | 0.820 |
CLK2 |
0.848 | 0.214 | -3 | 0.788 |
GRK4 |
0.848 | -0.141 | -2 | 0.794 |
CDK18 |
0.848 | 0.129 | 1 | 0.652 |
NEK2 |
0.848 | -0.018 | 2 | 0.850 |
PKACA |
0.847 | 0.187 | -2 | 0.670 |
AKT1 |
0.847 | 0.187 | -3 | 0.746 |
CDK1 |
0.847 | 0.137 | 1 | 0.667 |
AURA |
0.847 | 0.102 | -2 | 0.667 |
TGFBR1 |
0.847 | -0.010 | -2 | 0.764 |
ERK1 |
0.846 | 0.114 | 1 | 0.699 |
CAMK2A |
0.846 | 0.049 | 2 | 0.845 |
HIPK2 |
0.846 | 0.149 | 1 | 0.656 |
JNK3 |
0.846 | 0.109 | 1 | 0.707 |
MARK3 |
0.845 | 0.071 | 4 | 0.835 |
MARK2 |
0.845 | 0.056 | 4 | 0.798 |
DNAPK |
0.845 | 0.049 | 1 | 0.743 |
PLK4 |
0.844 | -0.011 | 2 | 0.693 |
DYRK1A |
0.844 | 0.119 | 1 | 0.781 |
ERK2 |
0.844 | 0.095 | 1 | 0.719 |
P38B |
0.844 | 0.129 | 1 | 0.709 |
CAMK1G |
0.844 | 0.063 | -3 | 0.803 |
CHAK1 |
0.844 | -0.052 | 2 | 0.814 |
VRK2 |
0.844 | -0.159 | 1 | 0.880 |
HIPK3 |
0.844 | 0.122 | 1 | 0.775 |
CDK2 |
0.844 | 0.120 | 1 | 0.739 |
MEK1 |
0.843 | -0.151 | 2 | 0.886 |
GRK7 |
0.843 | 0.038 | 1 | 0.752 |
DCAMKL1 |
0.843 | 0.099 | -3 | 0.820 |
SSTK |
0.843 | 0.111 | 4 | 0.867 |
IRAK4 |
0.843 | 0.046 | 1 | 0.807 |
PHKG2 |
0.843 | 0.088 | -3 | 0.837 |
PKCT |
0.843 | 0.105 | 2 | 0.781 |
CDK13 |
0.842 | 0.048 | 1 | 0.697 |
CDK3 |
0.842 | 0.190 | 1 | 0.617 |
SMMLCK |
0.842 | 0.101 | -3 | 0.852 |
SNRK |
0.842 | -0.090 | 2 | 0.743 |
ALK2 |
0.842 | 0.008 | -2 | 0.776 |
MLK4 |
0.842 | -0.056 | 2 | 0.771 |
CDK17 |
0.841 | 0.101 | 1 | 0.597 |
SMG1 |
0.841 | -0.042 | 1 | 0.786 |
CDK14 |
0.841 | 0.140 | 1 | 0.693 |
ACVR2A |
0.841 | -0.029 | -2 | 0.766 |
WNK4 |
0.841 | -0.013 | -2 | 0.807 |
P38G |
0.841 | 0.109 | 1 | 0.595 |
YSK4 |
0.840 | -0.137 | 1 | 0.790 |
BRAF |
0.840 | -0.008 | -4 | 0.824 |
PLK3 |
0.840 | -0.038 | 2 | 0.812 |
MARK1 |
0.840 | 0.028 | 4 | 0.855 |
P70S6K |
0.840 | 0.104 | -3 | 0.747 |
DCAMKL2 |
0.839 | 0.067 | -3 | 0.845 |
CHK1 |
0.839 | -0.026 | -3 | 0.854 |
HRI |
0.839 | -0.108 | -2 | 0.808 |
ACVR2B |
0.839 | -0.036 | -2 | 0.773 |
MEKK1 |
0.838 | -0.072 | 1 | 0.841 |
MST3 |
0.838 | 0.082 | 2 | 0.853 |
CDK10 |
0.838 | 0.165 | 1 | 0.680 |
NEK5 |
0.837 | -0.008 | 1 | 0.845 |
PERK |
0.837 | -0.105 | -2 | 0.798 |
MEKK2 |
0.837 | -0.031 | 2 | 0.853 |
CDK16 |
0.836 | 0.149 | 1 | 0.613 |
MEKK3 |
0.836 | -0.116 | 1 | 0.819 |
DYRK3 |
0.836 | 0.129 | 1 | 0.759 |
AKT3 |
0.836 | 0.182 | -3 | 0.663 |
CDK9 |
0.836 | 0.035 | 1 | 0.706 |
MPSK1 |
0.836 | 0.082 | 1 | 0.797 |
CDK12 |
0.836 | 0.053 | 1 | 0.673 |
DYRK1B |
0.836 | 0.109 | 1 | 0.694 |
CAMK1D |
0.835 | 0.102 | -3 | 0.737 |
MEK5 |
0.835 | -0.180 | 2 | 0.870 |
PAK5 |
0.835 | 0.104 | -2 | 0.632 |
MAPKAPK5 |
0.835 | -0.075 | -3 | 0.752 |
PKCI |
0.835 | 0.083 | 2 | 0.784 |
ZAK |
0.835 | -0.080 | 1 | 0.803 |
TLK2 |
0.834 | -0.144 | 1 | 0.797 |
MRCKB |
0.834 | 0.201 | -3 | 0.780 |
PRP4 |
0.834 | 0.036 | -3 | 0.766 |
SGK1 |
0.833 | 0.177 | -3 | 0.648 |
DAPK3 |
0.833 | 0.133 | -3 | 0.833 |
PKCE |
0.833 | 0.132 | 2 | 0.757 |
MAK |
0.833 | 0.203 | -2 | 0.737 |
DRAK1 |
0.833 | -0.099 | 1 | 0.748 |
TAO3 |
0.832 | 0.022 | 1 | 0.811 |
DYRK4 |
0.832 | 0.097 | 1 | 0.673 |
PAK4 |
0.832 | 0.105 | -2 | 0.648 |
MRCKA |
0.832 | 0.201 | -3 | 0.793 |
BMPR1A |
0.831 | 0.013 | 1 | 0.739 |
TLK1 |
0.831 | -0.134 | -2 | 0.794 |
IRAK1 |
0.830 | -0.144 | -1 | 0.778 |
ROCK2 |
0.830 | 0.214 | -3 | 0.816 |
GAK |
0.830 | 0.085 | 1 | 0.847 |
GRK2 |
0.830 | -0.127 | -2 | 0.686 |
TAO2 |
0.829 | 0.012 | 2 | 0.886 |
PKN1 |
0.829 | 0.083 | -3 | 0.765 |
PINK1 |
0.829 | -0.172 | 1 | 0.829 |
CK1E |
0.828 | -0.051 | -3 | 0.527 |
P38D |
0.828 | 0.100 | 1 | 0.627 |
PDK1 |
0.828 | 0.001 | 1 | 0.838 |
PASK |
0.828 | -0.010 | -3 | 0.869 |
TTBK1 |
0.827 | -0.142 | 2 | 0.665 |
NEK8 |
0.827 | -0.092 | 2 | 0.853 |
ERK7 |
0.827 | 0.055 | 2 | 0.563 |
NEK11 |
0.827 | -0.109 | 1 | 0.822 |
LKB1 |
0.826 | -0.002 | -3 | 0.849 |
DMPK1 |
0.826 | 0.237 | -3 | 0.800 |
NEK4 |
0.826 | -0.026 | 1 | 0.816 |
CAMK1A |
0.825 | 0.101 | -3 | 0.700 |
MOK |
0.825 | 0.164 | 1 | 0.777 |
TNIK |
0.825 | 0.101 | 3 | 0.862 |
CAMKK1 |
0.824 | -0.102 | -2 | 0.716 |
MEKK6 |
0.824 | -0.017 | 1 | 0.816 |
CDK6 |
0.824 | 0.110 | 1 | 0.681 |
EEF2K |
0.823 | 0.029 | 3 | 0.850 |
CHK2 |
0.823 | 0.068 | -3 | 0.679 |
GCK |
0.823 | 0.023 | 1 | 0.814 |
HGK |
0.823 | 0.027 | 3 | 0.862 |
PKG1 |
0.823 | 0.130 | -2 | 0.642 |
LOK |
0.823 | 0.052 | -2 | 0.730 |
CDK4 |
0.822 | 0.103 | 1 | 0.657 |
MINK |
0.822 | 0.023 | 1 | 0.819 |
DAPK1 |
0.822 | 0.077 | -3 | 0.816 |
MAP3K15 |
0.822 | -0.033 | 1 | 0.795 |
CAMKK2 |
0.821 | -0.090 | -2 | 0.714 |
NEK1 |
0.820 | 0.008 | 1 | 0.819 |
HPK1 |
0.819 | 0.022 | 1 | 0.804 |
CK1G1 |
0.819 | -0.089 | -3 | 0.524 |
KHS1 |
0.819 | 0.080 | 1 | 0.810 |
MST2 |
0.818 | -0.090 | 1 | 0.830 |
ROCK1 |
0.818 | 0.181 | -3 | 0.789 |
KHS2 |
0.818 | 0.104 | 1 | 0.814 |
GSK3A |
0.818 | -0.021 | 4 | 0.412 |
GSK3B |
0.818 | -0.070 | 4 | 0.403 |
CK1D |
0.817 | -0.065 | -3 | 0.476 |
BUB1 |
0.817 | 0.077 | -5 | 0.751 |
JNK1 |
0.817 | 0.047 | 1 | 0.650 |
TAK1 |
0.817 | -0.087 | 1 | 0.839 |
LRRK2 |
0.817 | -0.104 | 2 | 0.883 |
PBK |
0.816 | 0.075 | 1 | 0.799 |
CK1A2 |
0.815 | -0.064 | -3 | 0.477 |
CRIK |
0.815 | 0.164 | -3 | 0.742 |
YSK1 |
0.814 | -0.004 | 2 | 0.842 |
MST1 |
0.814 | -0.046 | 1 | 0.813 |
GRK3 |
0.813 | -0.133 | -2 | 0.647 |
PLK2 |
0.812 | -0.026 | -3 | 0.807 |
CK2A2 |
0.812 | 0.006 | 1 | 0.665 |
SLK |
0.812 | -0.044 | -2 | 0.668 |
RIPK2 |
0.812 | -0.200 | 1 | 0.784 |
SBK |
0.811 | 0.067 | -3 | 0.618 |
VRK1 |
0.811 | -0.182 | 2 | 0.869 |
TTK |
0.811 | 0.063 | -2 | 0.802 |
MEK2 |
0.808 | -0.218 | 2 | 0.863 |
NEK3 |
0.808 | -0.091 | 1 | 0.802 |
STK33 |
0.807 | -0.155 | 2 | 0.659 |
HASPIN |
0.806 | 0.043 | -1 | 0.741 |
BIKE |
0.804 | 0.076 | 1 | 0.741 |
PDHK3_TYR |
0.803 | 0.137 | 4 | 0.914 |
OSR1 |
0.800 | -0.062 | 2 | 0.843 |
CK2A1 |
0.799 | -0.031 | 1 | 0.638 |
ASK1 |
0.799 | -0.092 | 1 | 0.779 |
TAO1 |
0.798 | -0.035 | 1 | 0.758 |
TESK1_TYR |
0.798 | 0.039 | 3 | 0.875 |
MYO3B |
0.798 | -0.023 | 2 | 0.854 |
EPHA6 |
0.795 | 0.123 | -1 | 0.864 |
MYO3A |
0.795 | -0.043 | 1 | 0.790 |
PKMYT1_TYR |
0.794 | -0.022 | 3 | 0.851 |
LIMK2_TYR |
0.793 | 0.082 | -3 | 0.906 |
MAP2K7_TYR |
0.793 | -0.138 | 2 | 0.901 |
MAP2K4_TYR |
0.793 | -0.106 | -1 | 0.873 |
ALPHAK3 |
0.792 | -0.076 | -1 | 0.761 |
PDHK4_TYR |
0.792 | -0.033 | 2 | 0.907 |
PINK1_TYR |
0.791 | -0.091 | 1 | 0.834 |
MAP2K6_TYR |
0.790 | -0.096 | -1 | 0.873 |
RET |
0.790 | -0.005 | 1 | 0.825 |
AAK1 |
0.789 | 0.113 | 1 | 0.647 |
EPHB4 |
0.789 | 0.057 | -1 | 0.850 |
BMPR2_TYR |
0.789 | -0.052 | -1 | 0.868 |
TYRO3 |
0.789 | 0.007 | 3 | 0.814 |
ROS1 |
0.788 | 0.005 | 3 | 0.791 |
DDR1 |
0.787 | 0.002 | 4 | 0.852 |
TYK2 |
0.787 | -0.062 | 1 | 0.833 |
LIMK1_TYR |
0.786 | -0.098 | 2 | 0.899 |
PDHK1_TYR |
0.786 | -0.158 | -1 | 0.880 |
MST1R |
0.785 | -0.075 | 3 | 0.809 |
JAK2 |
0.784 | -0.069 | 1 | 0.837 |
CSF1R |
0.784 | -0.032 | 3 | 0.810 |
TNK2 |
0.783 | 0.064 | 3 | 0.780 |
YES1 |
0.783 | 0.023 | -1 | 0.833 |
TXK |
0.783 | 0.073 | 1 | 0.820 |
YANK3 |
0.782 | -0.115 | 2 | 0.421 |
STLK3 |
0.781 | -0.183 | 1 | 0.773 |
ABL2 |
0.781 | 0.013 | -1 | 0.797 |
TNK1 |
0.781 | 0.039 | 3 | 0.791 |
TNNI3K_TYR |
0.781 | 0.073 | 1 | 0.863 |
INSRR |
0.781 | -0.023 | 3 | 0.770 |
JAK3 |
0.780 | -0.064 | 1 | 0.800 |
BLK |
0.779 | 0.095 | -1 | 0.826 |
LCK |
0.779 | 0.051 | -1 | 0.820 |
HCK |
0.778 | -0.011 | -1 | 0.821 |
FGR |
0.778 | -0.072 | 1 | 0.861 |
PDGFRB |
0.778 | -0.074 | 3 | 0.821 |
EPHB1 |
0.777 | -0.021 | 1 | 0.856 |
EPHB3 |
0.777 | -0.007 | -1 | 0.839 |
ABL1 |
0.776 | -0.019 | -1 | 0.789 |
FER |
0.776 | -0.128 | 1 | 0.865 |
AXL |
0.776 | -0.026 | 3 | 0.788 |
KDR |
0.776 | -0.044 | 3 | 0.782 |
FGFR2 |
0.775 | -0.087 | 3 | 0.802 |
ITK |
0.775 | -0.030 | -1 | 0.802 |
EPHB2 |
0.775 | -0.007 | -1 | 0.825 |
EPHA4 |
0.775 | -0.050 | 2 | 0.802 |
JAK1 |
0.775 | -0.018 | 1 | 0.787 |
FLT3 |
0.774 | -0.092 | 3 | 0.812 |
TEC |
0.774 | -0.002 | -1 | 0.752 |
DDR2 |
0.774 | 0.090 | 3 | 0.760 |
MERTK |
0.774 | -0.022 | 3 | 0.784 |
TEK |
0.773 | -0.093 | 3 | 0.766 |
SRMS |
0.773 | -0.080 | 1 | 0.844 |
NEK10_TYR |
0.772 | -0.082 | 1 | 0.691 |
FGFR1 |
0.772 | -0.103 | 3 | 0.782 |
KIT |
0.772 | -0.120 | 3 | 0.812 |
EPHA7 |
0.771 | -0.013 | 2 | 0.813 |
LTK |
0.771 | -0.043 | 3 | 0.757 |
ALK |
0.770 | -0.082 | 3 | 0.740 |
BTK |
0.770 | -0.104 | -1 | 0.774 |
CK1A |
0.770 | -0.138 | -3 | 0.383 |
BMX |
0.769 | -0.044 | -1 | 0.725 |
EPHA1 |
0.769 | -0.023 | 3 | 0.767 |
PDGFRA |
0.769 | -0.168 | 3 | 0.822 |
MET |
0.768 | -0.098 | 3 | 0.789 |
FYN |
0.768 | 0.026 | -1 | 0.795 |
WEE1_TYR |
0.766 | -0.106 | -1 | 0.762 |
EPHA3 |
0.765 | -0.105 | 2 | 0.785 |
LYN |
0.764 | -0.041 | 3 | 0.743 |
FRK |
0.764 | -0.077 | -1 | 0.836 |
INSR |
0.764 | -0.121 | 3 | 0.743 |
FGFR3 |
0.763 | -0.130 | 3 | 0.781 |
NTRK2 |
0.763 | -0.153 | 3 | 0.773 |
NTRK1 |
0.763 | -0.192 | -1 | 0.809 |
FLT1 |
0.761 | -0.146 | -1 | 0.814 |
ERBB2 |
0.761 | -0.188 | 1 | 0.763 |
FLT4 |
0.760 | -0.170 | 3 | 0.776 |
EPHA5 |
0.760 | -0.050 | 2 | 0.801 |
PTK2B |
0.759 | -0.068 | -1 | 0.781 |
PTK6 |
0.758 | -0.250 | -1 | 0.724 |
EPHA8 |
0.756 | -0.081 | -1 | 0.813 |
NTRK3 |
0.756 | -0.156 | -1 | 0.761 |
CK1G3 |
0.756 | -0.122 | -3 | 0.337 |
SRC |
0.755 | -0.076 | -1 | 0.790 |
MATK |
0.752 | -0.164 | -1 | 0.716 |
CSK |
0.750 | -0.179 | 2 | 0.811 |
EGFR |
0.750 | -0.131 | 1 | 0.674 |
PTK2 |
0.749 | -0.047 | -1 | 0.780 |
YANK2 |
0.748 | -0.149 | 2 | 0.442 |
IGF1R |
0.748 | -0.141 | 3 | 0.687 |
FGFR4 |
0.747 | -0.147 | -1 | 0.749 |
EPHA2 |
0.745 | -0.108 | -1 | 0.775 |
MUSK |
0.742 | -0.185 | 1 | 0.662 |
SYK |
0.741 | -0.095 | -1 | 0.756 |
ERBB4 |
0.740 | -0.105 | 1 | 0.679 |
CK1G2 |
0.730 | -0.153 | -3 | 0.437 |
FES |
0.729 | -0.194 | -1 | 0.698 |
ZAP70 |
0.719 | -0.131 | -1 | 0.685 |