Motif 801 (n=180)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NJU9 | NPIPB13 | S1100 | ochoa | Nuclear pore complex-interacting protein family member B13 | None |
| A8MRT5 | NPIPB5 | S1066 | ochoa | Nuclear pore complex-interacting protein family member B5 | None |
| A8MT19 | RHPN2P1 | S496 | ochoa | Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) | None |
| C9JG80 | NPIPB4 | S1071 | ochoa | Nuclear pore complex-interacting protein family member B4 | None |
| E5RHQ5 | NPIPB11 | S1123 | ochoa | Nuclear pore complex-interacting protein family member B11 | None |
| O00567 | NOP56 | S462 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14492 | SH2B2 | S118 | ochoa | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}. |
| O14713 | ITGB1BP1 | S37 | ochoa | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}. |
| O14974 | PPP1R12A | S473 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O14981 | BTAF1 | S91 | ochoa | TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) | Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. |
| O15400 | STX7 | S129 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O60293 | ZFC3H1 | S805 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60303 | KATNIP | S253 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O60315 | ZEB2 | S851 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O60841 | EIF5B | S186 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75152 | ZC3H11A | S491 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75152 | ZC3H11A | S492 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75348 | ATP6V1G1 | S68 | ochoa | V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}. |
| O75563 | SKAP2 | S90 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O75962 | TRIO | S1821 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O76021 | RSL1D1 | S317 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O76070 | SNCG | S73 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| O95757 | HSPA4L | S587 | ochoa | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}. |
| O95936 | EOMES | S651 | ochoa | Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}. |
| P02545 | LMNA | S431 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P06748 | NPM1 | S217 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07814 | EPRS1 | S883 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P09429 | HMGB1 | S42 | ochoa|psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P0DMV8 | HSPA1A | S537 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S537 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P10636 | MAPT | S555 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11142 | HSPA8 | S544 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11171 | EPB41 | S152 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11388 | TOP2A | S1452 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P17028 | ZNF24 | S292 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P19525 | EIF2AK2 | S93 | ochoa | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P27694 | RPA1 | S177 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P29374 | ARID4A | S676 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P32249 | GPR183 | S333 | ochoa | G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2) | G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). {ECO:0000250|UniProtKB:Q3U6B2, ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:21796212, ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22913878, ECO:0000269|PubMed:22930711, ECO:0000269|PubMed:25297897}. |
| P35580 | MYH10 | S1938 | ochoa|psp | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35749 | MYH11 | S1315 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P42166 | TMPO | S159 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42677 | RPS27 | Y31 | ochoa | Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P43243 | MATR3 | S621 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P43307 | SSR1 | S246 | ochoa | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. |
| P45378 | TNNT3 | S167 | ochoa | Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P46013 | MKI67 | S330 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | S544 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46939 | UTRN | S830 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49792 | RANBP2 | S2805 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52701 | MSH6 | S280 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P55011 | SLC12A2 | S265 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P56856 | CLDN18 | S217 | ochoa | Claudin-18 | Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity). {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection. {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A2]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. {ECO:0000250|UniProtKB:P56857}. |
| P61764 | STXBP1 | S507 | ochoa | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P78527 | PRKDC | S3366 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78559 | MAP1A | S322 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q03164 | KMT2A | S941 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q09666 | AHNAK | S3412 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12824 | SMARCB1 | S139 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5) | Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. {ECO:0000250|UniProtKB:Q9Z0H3, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:12226744, ECO:0000269|PubMed:14604992, ECO:0000269|PubMed:16267391, ECO:0000269|PubMed:16314535, ECO:0000269|PubMed:9448295}. |
| Q13813 | SPTAN1 | S2142 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14004 | CDK13 | S528 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14202 | ZMYM3 | S960 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14524 | SCN5A | S460 | ochoa|psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14978 | NOLC1 | S132 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15147 | PLCB4 | S890 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) | Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927). {ECO:0000250|UniProtKB:Q07722, ECO:0000269|PubMed:35284927}. |
| Q15398 | DLGAP5 | S690 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15648 | MED1 | S1026 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15648 | MED1 | S1375 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15648 | MED1 | S1482 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15942 | ZYX | S153 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16537 | PPP2R5E | S33 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q16566 | CAMK4 | S344 | ochoa | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| Q16666 | IFI16 | S112 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q27J81 | INF2 | S1204 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2M2Z5 | KIZ | S623 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q2TB10 | ZNF800 | S422 | ochoa | Zinc finger protein 800 | May be involved in transcriptional regulation. |
| Q52LW3 | ARHGAP29 | S492 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53EL6 | PDCD4 | S71 | ochoa|psp | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5JTC6 | AMER1 | S45 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5M775 | SPECC1 | S315 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5M775 | SPECC1 | S917 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0W9 | FAM83B | S312 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T5C0 | STXBP5 | S905 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5T8P6 | RBM26 | S132 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5UIP0 | RIF1 | S1666 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1777 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S710 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VWN6 | TASOR2 | S343 | ochoa | Protein TASOR 2 | None |
| Q63HK5 | TSHZ3 | S600 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q658P3 | STEAP3 | S20 | ochoa | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}. |
| Q6FI81 | CIAPIN1 | S272 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6IE81 | JADE1 | S606 | ochoa | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
| Q6P0N0 | MIS18BP1 | S134 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P9G4 | TMEM154 | S115 | ochoa | Transmembrane protein 154 | None |
| Q6WCQ1 | MPRIP | S980 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZV73 | FGD6 | S652 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q71UM5 | RPS27L | S30 | ochoa | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | None |
| Q7Z4H7 | HAUS6 | S510 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z4V5 | HDGFL2 | S396 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z589 | EMSY | S213 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q7Z5K2 | WAPL | S159 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6E9 | RBBP6 | S1622 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z7G8 | VPS13B | S1815 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86U06 | RBM23 | S41 | ochoa | Probable RNA-binding protein 23 (CAPER beta) (CAPERbeta) (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2) | RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). {ECO:0000269|PubMed:15694343}. |
| Q86UE4 | MTDH | S219 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UU0 | BCL9L | S93 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86Y82 | STX12 | S142 | ochoa | Syntaxin-12 | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}. |
| Q8IUC4 | RHPN2 | S599 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8IV48 | ERI1 | S62 | ochoa | 3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487, PubMed:37352860). A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487). Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046). Able to bind other mRNAs (PubMed:14536070, PubMed:16912046). Required for 5.8S rRNA 3'-end processing (PubMed:37352860). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:16912046, PubMed:17135487). In vitro, does not have sequence specificity (PubMed:17135487). In vitro, has weak DNA exonuclease activity (PubMed:17135487). In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (PubMed:37352860). {ECO:0000250|UniProtKB:Q7TMF2, ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:14961122, ECO:0000269|PubMed:16912046, ECO:0000269|PubMed:17135487, ECO:0000269|PubMed:37352860}. |
| Q8IX03 | WWC1 | S152 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8N1G2 | CMTR1 | S29 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N3V7 | SYNPO | S721 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N488 | RYBP | S130 | ochoa | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}. |
| Q8NCF5 | NFATC2IP | S201 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NEM7 | SUPT20H | S381 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NEY8 | PPHLN1 | S208 | ochoa | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| Q8NFC6 | BOD1L1 | S545 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFC6 | BOD1L1 | S1101 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NI27 | THOC2 | S1393 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8NI27 | THOC2 | S1422 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8NI77 | KIF18A | S841 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TDD1 | DDX54 | S71 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8WUF8 | ARB2A | S220 | ochoa | Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A) | Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}. |
| Q8WWQ0 | PHIP | S1474 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WWY3 | PRPF31 | S451 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:28781166}. |
| Q92551 | IP6K1 | S146 | ochoa | Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
| Q92617 | NPIPB3 | S983 | ochoa | Nuclear pore complex-interacting protein family member B3 (Nuclear pore complex-interacting protein-like 3) (Protein pps22-1) | None |
| Q92692 | NECTIN2 | S520 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92734 | TFG | S153 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q92945 | KHSRP | S132 | ochoa|psp | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96GA3 | LTV1 | S358 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96GX5 | MASTL | S376 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96MY1 | NOL4L | S295 | ochoa | Nucleolar protein 4-like | None |
| Q96N46 | TTC14 | S583 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96RL1 | UIMC1 | S198 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96S38 | RPS6KC1 | S664 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99549 | MPHOSPH8 | S192 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99549 | MPHOSPH8 | S267 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99698 | LYST | S2170 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BQG0 | MYBBP1A | S1166 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BR61 | ACBD6 | S106 | ochoa | Acyl-CoA-binding domain-containing protein 6 | Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. Plays a role in protein N-myristoylation (PubMed:37951597). {ECO:0000269|PubMed:18268358, ECO:0000269|PubMed:37951597}. |
| Q9BRD0 | BUD13 | S299 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BTC0 | DIDO1 | S114 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BWT3 | PAPOLG | S516 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BY77 | POLDIP3 | S386 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BYB0 | SHANK3 | S558 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BYW2 | SETD2 | S1888 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BYW2 | SETD2 | S2085 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H0A0 | NAT10 | S987 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
| Q9H2F5 | EPC1 | S348 | ochoa | Enhancer of polycomb homolog 1 | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
| Q9H3C7 | GGNBP2 | S414 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
| Q9H4L7 | SMARCAD1 | S242 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9NQW6 | ANLN | S339 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRZ9 | HELLS | S165 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NX95 | SYBU | S128 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9P0L2 | MARK1 | S468 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P2B4 | CTTNBP2NL | S285 | ochoa | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9UBU7 | DBF4 | S362 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UIG0 | BAZ1B | S161 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJU6 | DBNL | S275 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q9UKA4 | AKAP11 | S1103 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9ULI0 | ATAD2B | S86 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UNZ2 | NSFL1C | S272 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPS6 | SETD1B | S1770 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UPZ3 | HPS5 | S436 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9UQ35 | SRRM2 | Y145 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQN3 | CHMP2B | S190 | ochoa | Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
| Q9UQR1 | ZNF148 | S352 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2H2 | INPP5F | S830 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y3E5 | PTRH2 | S57 | ochoa | Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1) | Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis (PubMed:14660562). Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. {ECO:0000269|PubMed:14660562, ECO:0000269|PubMed:15006356}. |
| Q9Y5B6 | PAXBP1 | S158 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| P42167 | TMPO | S159 | Sugiyama | Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| Q7Z2W4 | ZC3HAV1 | S640 | Sugiyama | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| P31948 | STIP1 | S45 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P17948 | FLT1 | S1291 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| Q14684 | RRP1B | S711 | Sugiyama | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q8N6T3 | ARFGAP1 | S273 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| P35580 | MYH10 | S1315 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P30086 | PEBP1 | S142 | Sugiyama | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| Q9H093 | NUAK2 | S389 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 7.660539e-14 | 13.116 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.289524e-12 | 11.890 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.345346e-12 | 11.630 |
| R-HSA-3371511 | HSF1 activation | 1.488420e-11 | 10.827 |
| R-HSA-3371556 | Cellular response to heat stress | 3.170142e-11 | 10.499 |
| R-HSA-2262752 | Cellular responses to stress | 2.233500e-05 | 4.651 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.764719e-04 | 3.753 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 5.158592e-04 | 3.287 |
| R-HSA-75153 | Apoptotic execution phase | 6.840639e-04 | 3.165 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 9.798517e-04 | 3.009 |
| R-HSA-9833482 | PKR-mediated signaling | 9.864679e-04 | 3.006 |
| R-HSA-1640170 | Cell Cycle | 1.062962e-03 | 2.973 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.226721e-03 | 2.911 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.433982e-03 | 2.843 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.493349e-03 | 2.826 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.452254e-03 | 2.838 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.970969e-03 | 2.705 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.280259e-03 | 2.484 |
| R-HSA-8953854 | Metabolism of RNA | 3.066667e-03 | 2.513 |
| R-HSA-68882 | Mitotic Anaphase | 3.433154e-03 | 2.464 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.528415e-03 | 2.452 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.033825e-03 | 2.394 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 5.114393e-03 | 2.291 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.760259e-03 | 2.170 |
| R-HSA-6794361 | Neurexins and neuroligins | 7.490326e-03 | 2.125 |
| R-HSA-9012852 | Signaling by NOTCH3 | 8.843532e-03 | 2.053 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 9.828896e-03 | 2.007 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 1.258893e-02 | 1.900 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.393319e-02 | 1.856 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.393319e-02 | 1.856 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.393319e-02 | 1.856 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.586347e-02 | 1.800 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.790115e-02 | 1.747 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.790115e-02 | 1.747 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.790115e-02 | 1.747 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.790115e-02 | 1.747 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.790115e-02 | 1.747 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.447332e-02 | 1.839 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.476746e-02 | 1.831 |
| R-HSA-9832991 | Formation of the posterior neural plate | 1.393319e-02 | 1.856 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.288845e-02 | 1.890 |
| R-HSA-4839744 | Signaling by APC mutants | 1.393319e-02 | 1.856 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.586347e-02 | 1.800 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.280677e-02 | 1.893 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.677751e-02 | 1.775 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.651855e-02 | 1.782 |
| R-HSA-68886 | M Phase | 1.448670e-02 | 1.839 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 1.677751e-02 | 1.775 |
| R-HSA-9930044 | Nuclear RNA decay | 1.380614e-02 | 1.860 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.648517e-02 | 1.783 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.031250e-02 | 1.692 |
| R-HSA-4839726 | Chromatin organization | 2.229500e-02 | 1.652 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.462896e-02 | 1.609 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.371242e-02 | 1.625 |
| R-HSA-9823739 | Formation of the anterior neural plate | 2.462896e-02 | 1.609 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.462896e-02 | 1.609 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 2.502014e-02 | 1.602 |
| R-HSA-169131 | Inhibition of PKR | 2.502014e-02 | 1.602 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.839918e-02 | 1.547 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.645960e-02 | 1.577 |
| R-HSA-68875 | Mitotic Prophase | 2.885240e-02 | 1.540 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.965032e-02 | 1.528 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.252648e-02 | 1.488 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.252648e-02 | 1.488 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.221929e-02 | 1.492 |
| R-HSA-5358508 | Mismatch Repair | 3.492832e-02 | 1.457 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.146349e-02 | 1.502 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.146349e-02 | 1.502 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.502083e-02 | 1.456 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 3.729561e-02 | 1.428 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.729561e-02 | 1.428 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 3.772244e-02 | 1.423 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.772244e-02 | 1.423 |
| R-HSA-72187 | mRNA 3'-end processing | 4.154656e-02 | 1.381 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.326705e-02 | 1.364 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 4.059909e-02 | 1.391 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 4.059909e-02 | 1.391 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 4.941727e-02 | 1.306 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.954586e-02 | 1.305 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 4.969954e-02 | 1.304 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 5.288184e-02 | 1.277 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 8.487847e-02 | 1.071 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.077848e-01 | 0.967 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.190231e-01 | 0.924 |
| R-HSA-9613354 | Lipophagy | 1.410787e-01 | 0.851 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.410787e-01 | 0.851 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.518997e-01 | 0.818 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.731362e-01 | 0.762 |
| R-HSA-9615710 | Late endosomal microautophagy | 7.337921e-02 | 1.134 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.239408e-01 | 0.650 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.239408e-01 | 0.650 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.337226e-01 | 0.631 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.529197e-01 | 0.597 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.716381e-01 | 0.566 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.808216e-01 | 0.552 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.457499e-01 | 0.836 |
| R-HSA-774815 | Nucleosome assembly | 1.457499e-01 | 0.836 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.898898e-01 | 0.538 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.898898e-01 | 0.538 |
| R-HSA-72649 | Translation initiation complex formation | 1.858363e-01 | 0.731 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.949517e-01 | 0.710 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.584564e-01 | 0.446 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.665503e-01 | 0.436 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.745425e-01 | 0.426 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.745425e-01 | 0.426 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.925876e-01 | 0.715 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.957883e-01 | 0.708 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.355569e-01 | 0.868 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.616826e-01 | 0.442 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.662142e-01 | 0.436 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.335523e-01 | 0.477 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.584564e-01 | 0.446 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 9.595557e-02 | 1.018 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.397256e-02 | 1.027 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.040028e-01 | 0.690 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.164175e-01 | 0.500 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.040028e-01 | 0.690 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.140347e-01 | 0.670 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.140347e-01 | 0.670 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.716381e-01 | 0.566 |
| R-HSA-156902 | Peptide chain elongation | 3.480183e-01 | 0.458 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.410787e-01 | 0.851 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.040028e-01 | 0.690 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.337226e-01 | 0.631 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.433817e-01 | 0.614 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.623380e-01 | 0.581 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.250390e-01 | 0.488 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.250390e-01 | 0.488 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.419588e-01 | 0.466 |
| R-HSA-180746 | Nuclear import of Rev protein | 9.595557e-02 | 1.018 |
| R-HSA-72172 | mRNA Splicing | 1.569527e-01 | 0.804 |
| R-HSA-68962 | Activation of the pre-replicative complex | 7.700930e-02 | 1.113 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 8.822554e-02 | 1.054 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.529197e-01 | 0.597 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.813022e-01 | 0.742 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.502597e-01 | 0.456 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.716381e-01 | 0.566 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.301205e-01 | 0.886 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.756642e-01 | 0.755 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.380013e-02 | 1.269 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.768529e-02 | 1.110 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.284528e-01 | 0.641 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.736812e-01 | 0.760 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.111518e-01 | 0.507 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.284528e-01 | 0.641 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.925876e-01 | 0.715 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.731362e-01 | 0.762 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.835552e-01 | 0.736 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 6.629396e-02 | 1.179 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 2.040028e-01 | 0.690 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.038705e-01 | 0.984 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.529197e-01 | 0.597 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.502597e-01 | 0.456 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.584564e-01 | 0.446 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.584564e-01 | 0.446 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.553485e-01 | 0.809 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.745425e-01 | 0.426 |
| R-HSA-68877 | Mitotic Prometaphase | 5.437375e-02 | 1.265 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.529197e-01 | 0.597 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.925876e-01 | 0.715 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.518997e-01 | 0.818 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.707334e-01 | 0.431 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.201999e-01 | 0.920 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.140347e-01 | 0.670 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.999672e-02 | 1.097 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.419588e-01 | 0.466 |
| R-HSA-9711097 | Cellular response to starvation | 1.856624e-01 | 0.731 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.140347e-01 | 0.670 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.250397e-01 | 0.488 |
| R-HSA-72312 | rRNA processing | 1.029266e-01 | 0.987 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 9.640385e-02 | 1.016 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 8.822554e-02 | 1.054 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.501122e-01 | 0.824 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.988443e-01 | 0.525 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.040028e-01 | 0.690 |
| R-HSA-1500620 | Meiosis | 1.153027e-01 | 0.938 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.272379e-01 | 0.644 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.328088e-02 | 1.079 |
| R-HSA-69481 | G2/M Checkpoints | 2.688487e-01 | 0.570 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.553485e-01 | 0.809 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.745425e-01 | 0.426 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.505268e-01 | 0.601 |
| R-HSA-913531 | Interferon Signaling | 1.433612e-01 | 0.844 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 6.138704e-02 | 1.212 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 9.640385e-02 | 1.016 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.731362e-01 | 0.762 |
| R-HSA-77387 | Insulin receptor recycling | 6.980675e-02 | 1.156 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 9.595557e-02 | 1.018 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.160593e-01 | 0.935 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.808216e-01 | 0.552 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.501122e-01 | 0.824 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.164175e-01 | 0.500 |
| R-HSA-1221632 | Meiotic synapsis | 1.813022e-01 | 0.742 |
| R-HSA-420029 | Tight junction interactions | 3.250390e-01 | 0.488 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.041225e-01 | 0.690 |
| R-HSA-112310 | Neurotransmitter release cycle | 3.571391e-01 | 0.447 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.335523e-01 | 0.477 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.787201e-02 | 1.168 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.140347e-01 | 0.670 |
| R-HSA-73894 | DNA Repair | 2.091531e-01 | 0.680 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 6.629396e-02 | 1.179 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.410922e-02 | 1.130 |
| R-HSA-112043 | PLC beta mediated events | 2.179645e-01 | 0.662 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.808216e-01 | 0.552 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 8.233786e-02 | 1.084 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 9.640385e-02 | 1.016 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.190231e-01 | 0.924 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 6.629396e-02 | 1.179 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.827795e-02 | 1.234 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.898898e-01 | 0.538 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.164175e-01 | 0.500 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.335523e-01 | 0.477 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.785517e-01 | 0.555 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.586405e-01 | 0.800 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.433817e-01 | 0.614 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.893583e-01 | 0.539 |
| R-HSA-9758941 | Gastrulation | 1.634401e-01 | 0.787 |
| R-HSA-112040 | G-protein mediated events | 2.458605e-01 | 0.609 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.410787e-01 | 0.851 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.529503e-02 | 1.185 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.434418e-01 | 0.464 |
| R-HSA-447041 | CHL1 interactions | 1.190231e-01 | 0.924 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.835552e-01 | 0.736 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.835552e-01 | 0.736 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.835552e-01 | 0.736 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 7.700930e-02 | 1.113 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.040028e-01 | 0.690 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.911888e-02 | 1.160 |
| R-HSA-3214847 | HATs acetylate histones | 1.644376e-01 | 0.784 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.832200e-01 | 0.548 |
| R-HSA-73886 | Chromosome Maintenance | 2.451574e-01 | 0.611 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.087261e-01 | 0.680 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.518997e-01 | 0.818 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.337226e-01 | 0.631 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.858363e-01 | 0.731 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.335523e-01 | 0.477 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.243767e-01 | 0.905 |
| R-HSA-1474165 | Reproduction | 1.159348e-01 | 0.936 |
| R-HSA-168255 | Influenza Infection | 1.086978e-01 | 0.964 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.076890e-01 | 0.512 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.458605e-01 | 0.609 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.190231e-01 | 0.924 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.040028e-01 | 0.690 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.949517e-01 | 0.710 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.502597e-01 | 0.456 |
| R-HSA-112316 | Neuronal System | 2.814719e-01 | 0.551 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 8.487847e-02 | 1.071 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.190231e-01 | 0.924 |
| R-HSA-9839394 | TGFBR3 expression | 3.250390e-01 | 0.488 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 6.629396e-02 | 1.179 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.285881e-01 | 0.891 |
| R-HSA-8876725 | Protein methylation | 2.140347e-01 | 0.670 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.529197e-01 | 0.597 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.665503e-01 | 0.436 |
| R-HSA-9833110 | RSV-host interactions | 1.830682e-01 | 0.737 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.584564e-01 | 0.446 |
| R-HSA-73884 | Base Excision Repair | 3.571391e-01 | 0.447 |
| R-HSA-1500931 | Cell-Cell communication | 1.369217e-01 | 0.864 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.453096e-01 | 0.838 |
| R-HSA-446728 | Cell junction organization | 3.269236e-01 | 0.486 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.133404e-01 | 0.671 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.160593e-01 | 0.935 |
| R-HSA-917937 | Iron uptake and transport | 8.953584e-02 | 1.048 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.598664e-01 | 0.585 |
| R-HSA-9675135 | Diseases of DNA repair | 1.501122e-01 | 0.824 |
| R-HSA-5620971 | Pyroptosis | 6.980675e-02 | 1.156 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.745425e-01 | 0.426 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.562608e-01 | 0.806 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.945578e-02 | 1.226 |
| R-HSA-373753 | Nephrin family interactions | 2.716381e-01 | 0.566 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.250390e-01 | 0.488 |
| R-HSA-422475 | Axon guidance | 1.836799e-01 | 0.736 |
| R-HSA-1538133 | G0 and Early G1 | 8.443440e-02 | 1.073 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.518997e-01 | 0.818 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.988443e-01 | 0.525 |
| R-HSA-9675108 | Nervous system development | 1.459009e-01 | 0.836 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.972064e-01 | 0.527 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.430905e-02 | 1.192 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.111518e-01 | 0.507 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.598664e-01 | 0.585 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.738815e-01 | 0.562 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.707334e-01 | 0.431 |
| R-HSA-373760 | L1CAM interactions | 2.284528e-01 | 0.641 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.405733e-01 | 0.852 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.581838e-01 | 0.446 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.433817e-01 | 0.614 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.629396e-02 | 1.179 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.418760e-01 | 0.466 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.164175e-01 | 0.500 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.164175e-01 | 0.500 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.832200e-01 | 0.548 |
| R-HSA-109581 | Apoptosis | 8.035150e-02 | 1.095 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.419588e-01 | 0.466 |
| R-HSA-5357801 | Programmed Cell Death | 6.822096e-02 | 1.166 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.332442e-01 | 0.875 |
| R-HSA-5218859 | Regulated Necrosis | 2.505268e-01 | 0.601 |
| R-HSA-2028269 | Signaling by Hippo | 2.433817e-01 | 0.614 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.529197e-01 | 0.597 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.988443e-01 | 0.525 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.365390e-01 | 0.626 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.020198e-01 | 0.991 |
| R-HSA-373755 | Semaphorin interactions | 2.272379e-01 | 0.644 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 2.785517e-01 | 0.555 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.878856e-01 | 0.541 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.434418e-01 | 0.464 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.753202e-01 | 0.426 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.790327e-01 | 0.421 |
| R-HSA-69190 | DNA strand elongation | 3.824343e-01 | 0.417 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.842132e-01 | 0.415 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.886792e-01 | 0.410 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.886792e-01 | 0.410 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.902271e-01 | 0.409 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.902271e-01 | 0.409 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.902271e-01 | 0.409 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.902271e-01 | 0.409 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.902271e-01 | 0.409 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.902271e-01 | 0.409 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.902271e-01 | 0.409 |
| R-HSA-9733709 | Cardiogenesis | 3.902271e-01 | 0.409 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.902271e-01 | 0.409 |
| R-HSA-390522 | Striated Muscle Contraction | 3.979220e-01 | 0.400 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.979220e-01 | 0.400 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.979220e-01 | 0.400 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.979220e-01 | 0.400 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.979220e-01 | 0.400 |
| R-HSA-6798695 | Neutrophil degranulation | 4.027372e-01 | 0.395 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.055203e-01 | 0.392 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 4.055203e-01 | 0.392 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.055203e-01 | 0.392 |
| R-HSA-5673000 | RAF activation | 4.055203e-01 | 0.392 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.055203e-01 | 0.392 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.055203e-01 | 0.392 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.055203e-01 | 0.392 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.059199e-01 | 0.392 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.063974e-01 | 0.391 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.130231e-01 | 0.384 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.130231e-01 | 0.384 |
| R-HSA-381042 | PERK regulates gene expression | 4.130231e-01 | 0.384 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.151644e-01 | 0.382 |
| R-HSA-157118 | Signaling by NOTCH | 4.188171e-01 | 0.378 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.195238e-01 | 0.377 |
| R-HSA-111933 | Calmodulin induced events | 4.204317e-01 | 0.376 |
| R-HSA-111997 | CaM pathway | 4.204317e-01 | 0.376 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.204317e-01 | 0.376 |
| R-HSA-8853659 | RET signaling | 4.204317e-01 | 0.376 |
| R-HSA-192823 | Viral mRNA Translation | 4.238667e-01 | 0.373 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.277473e-01 | 0.369 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.277473e-01 | 0.369 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.277473e-01 | 0.369 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.281929e-01 | 0.368 |
| R-HSA-111885 | Opioid Signalling | 4.281929e-01 | 0.368 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.349710e-01 | 0.362 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.349710e-01 | 0.362 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.349710e-01 | 0.362 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 4.349710e-01 | 0.362 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.421039e-01 | 0.354 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.421039e-01 | 0.354 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.421039e-01 | 0.354 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.491472e-01 | 0.348 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.491472e-01 | 0.348 |
| R-HSA-5260271 | Diseases of Immune System | 4.491472e-01 | 0.348 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.491472e-01 | 0.348 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.491472e-01 | 0.348 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.495636e-01 | 0.347 |
| R-HSA-421270 | Cell-cell junction organization | 4.496743e-01 | 0.347 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.537841e-01 | 0.343 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.561020e-01 | 0.341 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.561020e-01 | 0.341 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.629694e-01 | 0.334 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.629694e-01 | 0.334 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.663341e-01 | 0.331 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.663341e-01 | 0.331 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.697506e-01 | 0.328 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.697506e-01 | 0.328 |
| R-HSA-111996 | Ca-dependent events | 4.697506e-01 | 0.328 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.697506e-01 | 0.328 |
| R-HSA-73928 | Depyrimidination | 4.697506e-01 | 0.328 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.721299e-01 | 0.326 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.746060e-01 | 0.324 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.764465e-01 | 0.322 |
| R-HSA-69275 | G2/M Transition | 4.817856e-01 | 0.317 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.830583e-01 | 0.316 |
| R-HSA-373752 | Netrin-1 signaling | 4.830583e-01 | 0.316 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.830583e-01 | 0.316 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.830583e-01 | 0.316 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.868681e-01 | 0.313 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.881766e-01 | 0.311 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.895870e-01 | 0.310 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.895870e-01 | 0.310 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.895870e-01 | 0.310 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.895870e-01 | 0.310 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.949439e-01 | 0.305 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.960336e-01 | 0.304 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.960336e-01 | 0.304 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.960336e-01 | 0.304 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.960336e-01 | 0.304 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.960336e-01 | 0.304 |
| R-HSA-5693538 | Homology Directed Repair | 4.989516e-01 | 0.302 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.023992e-01 | 0.299 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.086848e-01 | 0.294 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.086848e-01 | 0.294 |
| R-HSA-73893 | DNA Damage Bypass | 5.148914e-01 | 0.288 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.225680e-01 | 0.282 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.256926e-01 | 0.279 |
| R-HSA-912446 | Meiotic recombination | 5.270715e-01 | 0.278 |
| R-HSA-69206 | G1/S Transition | 5.302736e-01 | 0.275 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.330469e-01 | 0.273 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.330469e-01 | 0.273 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.330469e-01 | 0.273 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.389472e-01 | 0.268 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.389472e-01 | 0.268 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.447733e-01 | 0.264 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.505261e-01 | 0.259 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.562066e-01 | 0.255 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.562066e-01 | 0.255 |
| R-HSA-177929 | Signaling by EGFR | 5.562066e-01 | 0.255 |
| R-HSA-9909396 | Circadian clock | 5.602460e-01 | 0.252 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.618156e-01 | 0.250 |
| R-HSA-397014 | Muscle contraction | 5.645815e-01 | 0.248 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.673541e-01 | 0.246 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.673541e-01 | 0.246 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.673541e-01 | 0.246 |
| R-HSA-162582 | Signal Transduction | 5.727077e-01 | 0.242 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.728229e-01 | 0.242 |
| R-HSA-191859 | snRNP Assembly | 5.728229e-01 | 0.242 |
| R-HSA-180786 | Extension of Telomeres | 5.728229e-01 | 0.242 |
| R-HSA-195721 | Signaling by WNT | 5.740820e-01 | 0.241 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.782229e-01 | 0.238 |
| R-HSA-379724 | tRNA Aminoacylation | 5.782229e-01 | 0.238 |
| R-HSA-983189 | Kinesins | 5.782229e-01 | 0.238 |
| R-HSA-418990 | Adherens junctions interactions | 5.818676e-01 | 0.235 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.835550e-01 | 0.234 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.853390e-01 | 0.233 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.888201e-01 | 0.230 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.888201e-01 | 0.230 |
| R-HSA-9707616 | Heme signaling | 5.888201e-01 | 0.230 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.888201e-01 | 0.230 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.940188e-01 | 0.226 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.940188e-01 | 0.226 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.940188e-01 | 0.226 |
| R-HSA-1632852 | Macroautophagy | 5.957665e-01 | 0.225 |
| R-HSA-9679506 | SARS-CoV Infections | 5.969100e-01 | 0.224 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.026091e-01 | 0.220 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.059976e-01 | 0.218 |
| R-HSA-162906 | HIV Infection | 6.069748e-01 | 0.217 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.092259e-01 | 0.215 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.092259e-01 | 0.215 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.092259e-01 | 0.215 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.097023e-01 | 0.215 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.141679e-01 | 0.212 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.190477e-01 | 0.208 |
| R-HSA-69242 | S Phase | 6.226133e-01 | 0.206 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.286238e-01 | 0.202 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.333217e-01 | 0.198 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.333217e-01 | 0.198 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.335010e-01 | 0.198 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.355145e-01 | 0.197 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.379604e-01 | 0.195 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.379604e-01 | 0.195 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.379604e-01 | 0.195 |
| R-HSA-69306 | DNA Replication | 6.386857e-01 | 0.195 |
| R-HSA-73887 | Death Receptor Signaling | 6.418353e-01 | 0.193 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.425407e-01 | 0.192 |
| R-HSA-9612973 | Autophagy | 6.480698e-01 | 0.188 |
| R-HSA-9610379 | HCMV Late Events | 6.511549e-01 | 0.186 |
| R-HSA-162587 | HIV Life Cycle | 6.511549e-01 | 0.186 |
| R-HSA-380287 | Centrosome maturation | 6.515290e-01 | 0.186 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.515290e-01 | 0.186 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.515290e-01 | 0.186 |
| R-HSA-8852135 | Protein ubiquitination | 6.515290e-01 | 0.186 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.559385e-01 | 0.183 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.645915e-01 | 0.177 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.645915e-01 | 0.177 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.645915e-01 | 0.177 |
| R-HSA-9659379 | Sensory processing of sound | 6.688365e-01 | 0.175 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.688365e-01 | 0.175 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.730280e-01 | 0.172 |
| R-HSA-72766 | Translation | 6.764523e-01 | 0.170 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.852883e-01 | 0.164 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.853148e-01 | 0.164 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.892726e-01 | 0.162 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.892726e-01 | 0.162 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.893929e-01 | 0.162 |
| R-HSA-72306 | tRNA processing | 6.921207e-01 | 0.160 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.932066e-01 | 0.159 |
| R-HSA-416476 | G alpha (q) signalling events | 6.993888e-01 | 0.155 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.003682e-01 | 0.155 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.003682e-01 | 0.155 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.009267e-01 | 0.154 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.047139e-01 | 0.152 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.057647e-01 | 0.151 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.084534e-01 | 0.150 |
| R-HSA-9663891 | Selective autophagy | 7.084534e-01 | 0.150 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.084534e-01 | 0.150 |
| R-HSA-74160 | Gene expression (Transcription) | 7.117031e-01 | 0.148 |
| R-HSA-1236974 | ER-Phagosome pathway | 7.121457e-01 | 0.147 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.157916e-01 | 0.145 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.193914e-01 | 0.143 |
| R-HSA-391251 | Protein folding | 7.264556e-01 | 0.139 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 7.367214e-01 | 0.133 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.367214e-01 | 0.133 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.377962e-01 | 0.132 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.395820e-01 | 0.131 |
| R-HSA-983712 | Ion channel transport | 7.413146e-01 | 0.130 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.433514e-01 | 0.129 |
| R-HSA-157579 | Telomere Maintenance | 7.466038e-01 | 0.127 |
| R-HSA-199991 | Membrane Trafficking | 7.468052e-01 | 0.127 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.484399e-01 | 0.126 |
| R-HSA-422356 | Regulation of insulin secretion | 7.498152e-01 | 0.125 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.498152e-01 | 0.125 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.498152e-01 | 0.125 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.498152e-01 | 0.125 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.519380e-01 | 0.124 |
| R-HSA-70171 | Glycolysis | 7.561170e-01 | 0.121 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.576787e-01 | 0.121 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.592084e-01 | 0.120 |
| R-HSA-1483255 | PI Metabolism | 7.622608e-01 | 0.118 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.652685e-01 | 0.116 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.731450e-01 | 0.112 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.740901e-01 | 0.111 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.740901e-01 | 0.111 |
| R-HSA-418346 | Platelet homeostasis | 7.769548e-01 | 0.110 |
| R-HSA-69239 | Synthesis of DNA | 7.797833e-01 | 0.108 |
| R-HSA-211000 | Gene Silencing by RNA | 7.797833e-01 | 0.108 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.825761e-01 | 0.106 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.825761e-01 | 0.106 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.825761e-01 | 0.106 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.853336e-01 | 0.105 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.880564e-01 | 0.103 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.880564e-01 | 0.103 |
| R-HSA-9824446 | Viral Infection Pathways | 7.928583e-01 | 0.101 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.937492e-01 | 0.100 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.960201e-01 | 0.099 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.036861e-01 | 0.095 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.066229e-01 | 0.093 |
| R-HSA-70326 | Glucose metabolism | 8.110653e-01 | 0.091 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.145931e-01 | 0.089 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.158307e-01 | 0.088 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.158307e-01 | 0.088 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.227556e-01 | 0.085 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.227556e-01 | 0.085 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.250058e-01 | 0.084 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.250058e-01 | 0.084 |
| R-HSA-1266738 | Developmental Biology | 8.277416e-01 | 0.082 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.315872e-01 | 0.080 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.315872e-01 | 0.080 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.315872e-01 | 0.080 |
| R-HSA-194138 | Signaling by VEGF | 8.315872e-01 | 0.080 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.420134e-01 | 0.075 |
| R-HSA-9843745 | Adipogenesis | 8.460017e-01 | 0.073 |
| R-HSA-5576891 | Cardiac conduction | 8.460017e-01 | 0.073 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.573754e-01 | 0.067 |
| R-HSA-163685 | Integration of energy metabolism | 8.573754e-01 | 0.067 |
| R-HSA-9609646 | HCMV Infection | 8.577435e-01 | 0.067 |
| R-HSA-5688426 | Deubiquitination | 8.646686e-01 | 0.063 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.660161e-01 | 0.062 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.695922e-01 | 0.061 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.792311e-01 | 0.056 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.812571e-01 | 0.055 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.822838e-01 | 0.054 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.837813e-01 | 0.054 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.852598e-01 | 0.053 |
| R-HSA-1989781 | PPARA activates gene expression | 8.895839e-01 | 0.051 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.923761e-01 | 0.049 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.964333e-01 | 0.047 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.964333e-01 | 0.047 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.044753e-01 | 0.044 |
| R-HSA-5619102 | SLC transporter disorders | 9.053178e-01 | 0.043 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.066775e-01 | 0.043 |
| R-HSA-418594 | G alpha (i) signalling events | 9.096513e-01 | 0.041 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.123267e-01 | 0.040 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.134436e-01 | 0.039 |
| R-HSA-449147 | Signaling by Interleukins | 9.148237e-01 | 0.039 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.263788e-01 | 0.033 |
| R-HSA-5617833 | Cilium Assembly | 9.304033e-01 | 0.031 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.312909e-01 | 0.031 |
| R-HSA-9609690 | HCMV Early Events | 9.355627e-01 | 0.029 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.387890e-01 | 0.027 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.449408e-01 | 0.025 |
| R-HSA-8951664 | Neddylation | 9.538645e-01 | 0.021 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.583763e-01 | 0.018 |
| R-HSA-168249 | Innate Immune System | 9.597162e-01 | 0.018 |
| R-HSA-8939211 | ESR-mediated signaling | 9.624489e-01 | 0.017 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.649439e-01 | 0.015 |
| R-HSA-212436 | Generic Transcription Pathway | 9.666419e-01 | 0.015 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.669863e-01 | 0.015 |
| R-HSA-597592 | Post-translational protein modification | 9.688774e-01 | 0.014 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.731381e-01 | 0.012 |
| R-HSA-388396 | GPCR downstream signalling | 9.747537e-01 | 0.011 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.789783e-01 | 0.009 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.822276e-01 | 0.008 |
| R-HSA-1483257 | Phospholipid metabolism | 9.822276e-01 | 0.008 |
| R-HSA-1643685 | Disease | 9.868515e-01 | 0.006 |
| R-HSA-8957322 | Metabolism of steroids | 9.877859e-01 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 9.878825e-01 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.884175e-01 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 9.888443e-01 | 0.005 |
| R-HSA-168256 | Immune System | 9.890120e-01 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 9.897165e-01 | 0.004 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.926323e-01 | 0.003 |
| R-HSA-5663205 | Infectious disease | 9.935169e-01 | 0.003 |
| R-HSA-1280218 | Adaptive Immune System | 9.937276e-01 | 0.003 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.951382e-01 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.953242e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.958946e-01 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.978040e-01 | 0.001 |
| R-HSA-109582 | Hemostasis | 9.980241e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.989570e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.996210e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999995e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999999e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1E |
0.817 | 0.488 | -3 | 0.793 |
CK1D |
0.814 | 0.491 | -3 | 0.788 |
COT |
0.813 | 0.223 | 2 | 0.883 |
CK1A2 |
0.810 | 0.492 | -3 | 0.783 |
GRK1 |
0.809 | 0.313 | -2 | 0.751 |
KIS |
0.807 | 0.201 | 1 | 0.754 |
CLK3 |
0.804 | 0.140 | 1 | 0.856 |
MOS |
0.798 | 0.217 | 1 | 0.827 |
BMPR1B |
0.794 | 0.225 | 1 | 0.809 |
CK1G1 |
0.794 | 0.393 | -3 | 0.761 |
IKKB |
0.791 | 0.073 | -2 | 0.708 |
CDC7 |
0.791 | 0.060 | 1 | 0.819 |
CK1A |
0.790 | 0.426 | -3 | 0.774 |
GRK6 |
0.788 | 0.224 | 1 | 0.802 |
DSTYK |
0.787 | 0.029 | 2 | 0.898 |
MTOR |
0.785 | 0.007 | 1 | 0.759 |
GRK5 |
0.785 | 0.154 | -3 | 0.572 |
PIM3 |
0.784 | -0.006 | -3 | 0.420 |
ERK5 |
0.782 | 0.073 | 1 | 0.862 |
PRPK |
0.781 | -0.043 | -1 | 0.644 |
GRK7 |
0.781 | 0.161 | 1 | 0.746 |
IKKA |
0.781 | 0.040 | -2 | 0.701 |
NLK |
0.780 | 0.056 | 1 | 0.839 |
MLK1 |
0.780 | 0.107 | 2 | 0.817 |
GRK4 |
0.780 | 0.139 | -2 | 0.781 |
FAM20C |
0.779 | 0.100 | 2 | 0.679 |
ATR |
0.779 | 0.022 | 1 | 0.792 |
ACVR2B |
0.779 | 0.185 | -2 | 0.788 |
RAF1 |
0.778 | -0.029 | 1 | 0.783 |
CAMK2G |
0.778 | 0.013 | 2 | 0.808 |
BMPR2 |
0.777 | 0.008 | -2 | 0.852 |
BMPR1A |
0.777 | 0.182 | 1 | 0.778 |
ACVR2A |
0.777 | 0.173 | -2 | 0.781 |
CDKL1 |
0.777 | -0.009 | -3 | 0.382 |
CDK1 |
0.776 | 0.120 | 1 | 0.732 |
SKMLCK |
0.775 | 0.027 | -2 | 0.856 |
GRK3 |
0.775 | 0.194 | -2 | 0.642 |
GRK2 |
0.774 | 0.152 | -2 | 0.681 |
SRPK1 |
0.774 | 0.002 | -3 | 0.345 |
TGFBR1 |
0.774 | 0.102 | -2 | 0.801 |
TBK1 |
0.773 | -0.052 | 1 | 0.674 |
IKKE |
0.773 | -0.042 | 1 | 0.675 |
NDR2 |
0.773 | -0.062 | -3 | 0.416 |
CDKL5 |
0.773 | 0.010 | -3 | 0.360 |
CDK8 |
0.772 | 0.067 | 1 | 0.730 |
PDHK4 |
0.772 | -0.180 | 1 | 0.793 |
NEK6 |
0.772 | -0.066 | -2 | 0.827 |
CAMK1B |
0.771 | -0.060 | -3 | 0.411 |
GCN2 |
0.771 | -0.116 | 2 | 0.764 |
RIPK3 |
0.771 | 0.018 | 3 | 0.779 |
PIM1 |
0.771 | -0.016 | -3 | 0.391 |
CLK2 |
0.770 | 0.073 | -3 | 0.343 |
ALK4 |
0.769 | 0.092 | -2 | 0.826 |
P38B |
0.769 | 0.123 | 1 | 0.741 |
DYRK2 |
0.768 | 0.064 | 1 | 0.758 |
NEK7 |
0.768 | -0.093 | -3 | 0.459 |
JNK3 |
0.768 | 0.103 | 1 | 0.730 |
HIPK4 |
0.768 | 0.008 | 1 | 0.787 |
DLK |
0.768 | 0.080 | 1 | 0.769 |
RSK2 |
0.768 | -0.044 | -3 | 0.329 |
MLK3 |
0.768 | 0.045 | 2 | 0.762 |
CDK19 |
0.768 | 0.071 | 1 | 0.703 |
ICK |
0.768 | 0.017 | -3 | 0.396 |
TGFBR2 |
0.768 | -0.030 | -2 | 0.800 |
ALK2 |
0.767 | 0.109 | -2 | 0.802 |
ERK1 |
0.767 | 0.110 | 1 | 0.721 |
ATM |
0.766 | 0.011 | 1 | 0.734 |
PKN3 |
0.766 | -0.070 | -3 | 0.386 |
MLK4 |
0.765 | 0.076 | 2 | 0.726 |
CDK18 |
0.765 | 0.087 | 1 | 0.698 |
MST4 |
0.765 | -0.020 | 2 | 0.853 |
CHAK2 |
0.764 | -0.029 | -1 | 0.593 |
SRPK2 |
0.764 | -0.024 | -3 | 0.298 |
JNK2 |
0.764 | 0.100 | 1 | 0.706 |
CAMLCK |
0.764 | -0.032 | -2 | 0.851 |
P38G |
0.764 | 0.104 | 1 | 0.655 |
CK1G3 |
0.763 | 0.396 | -3 | 0.755 |
PLK1 |
0.763 | 0.018 | -2 | 0.803 |
CAMK2B |
0.763 | -0.006 | 2 | 0.802 |
NIK |
0.762 | -0.107 | -3 | 0.436 |
HIPK2 |
0.762 | 0.082 | 1 | 0.684 |
ULK2 |
0.762 | -0.185 | 2 | 0.749 |
CLK4 |
0.762 | 0.026 | -3 | 0.353 |
P38A |
0.762 | 0.095 | 1 | 0.783 |
SRPK3 |
0.762 | -0.016 | -3 | 0.358 |
DAPK2 |
0.761 | -0.055 | -3 | 0.411 |
PKN2 |
0.761 | -0.052 | -3 | 0.402 |
NDR1 |
0.761 | -0.096 | -3 | 0.389 |
CK2A2 |
0.761 | 0.121 | 1 | 0.734 |
CDK5 |
0.761 | 0.075 | 1 | 0.765 |
AURC |
0.761 | 0.022 | -2 | 0.699 |
P38D |
0.760 | 0.115 | 1 | 0.662 |
ANKRD3 |
0.760 | -0.029 | 1 | 0.784 |
PDHK1 |
0.760 | -0.233 | 1 | 0.771 |
MEKK3 |
0.760 | 0.162 | 1 | 0.744 |
NUAK2 |
0.760 | -0.093 | -3 | 0.405 |
P90RSK |
0.759 | -0.081 | -3 | 0.331 |
CDK17 |
0.759 | 0.082 | 1 | 0.660 |
HUNK |
0.759 | -0.124 | 2 | 0.782 |
WNK1 |
0.758 | -0.095 | -2 | 0.845 |
CDK7 |
0.758 | 0.039 | 1 | 0.748 |
MASTL |
0.758 | -0.146 | -2 | 0.779 |
MLK2 |
0.758 | -0.071 | 2 | 0.809 |
PRKD1 |
0.757 | -0.110 | -3 | 0.345 |
BCKDK |
0.757 | -0.132 | -1 | 0.557 |
MAPKAPK2 |
0.757 | -0.067 | -3 | 0.302 |
MEK1 |
0.757 | 0.046 | 2 | 0.824 |
PRKX |
0.757 | 0.006 | -3 | 0.302 |
ERK2 |
0.757 | 0.077 | 1 | 0.743 |
PKCD |
0.757 | -0.054 | 2 | 0.796 |
CK1G2 |
0.757 | 0.375 | -3 | 0.766 |
CK2A1 |
0.756 | 0.137 | 1 | 0.720 |
LATS1 |
0.756 | -0.026 | -3 | 0.399 |
CAMK2A |
0.756 | -0.037 | 2 | 0.812 |
PKACG |
0.756 | -0.041 | -2 | 0.745 |
YSK4 |
0.756 | -0.027 | 1 | 0.710 |
CDK13 |
0.756 | 0.045 | 1 | 0.723 |
PKACB |
0.756 | 0.002 | -2 | 0.708 |
RSK4 |
0.755 | -0.031 | -3 | 0.336 |
CDK16 |
0.755 | 0.091 | 1 | 0.669 |
DYRK4 |
0.755 | 0.076 | 1 | 0.706 |
ULK1 |
0.755 | -0.169 | -3 | 0.427 |
HIPK1 |
0.755 | 0.052 | 1 | 0.763 |
P70S6KB |
0.755 | -0.080 | -3 | 0.351 |
GSK3A |
0.754 | 0.081 | 4 | 0.501 |
CAMK2D |
0.754 | -0.119 | -3 | 0.371 |
MSK1 |
0.754 | -0.016 | -3 | 0.332 |
CDK3 |
0.754 | 0.076 | 1 | 0.679 |
AURA |
0.754 | 0.041 | -2 | 0.686 |
PRKD2 |
0.754 | -0.100 | -3 | 0.307 |
TTBK2 |
0.753 | -0.060 | 2 | 0.664 |
MYLK4 |
0.753 | 0.006 | -2 | 0.785 |
TLK2 |
0.753 | -0.018 | 1 | 0.731 |
PRP4 |
0.753 | 0.011 | -3 | 0.405 |
MSK2 |
0.753 | -0.059 | -3 | 0.346 |
PASK |
0.753 | 0.051 | -3 | 0.456 |
CLK1 |
0.752 | -0.008 | -3 | 0.307 |
MARK4 |
0.752 | -0.134 | 4 | 0.763 |
CDK14 |
0.752 | 0.075 | 1 | 0.731 |
PLK3 |
0.752 | -0.050 | 2 | 0.758 |
NEK9 |
0.750 | -0.177 | 2 | 0.806 |
RSK3 |
0.750 | -0.103 | -3 | 0.321 |
CDK2 |
0.750 | 0.022 | 1 | 0.791 |
LATS2 |
0.750 | -0.115 | -5 | 0.658 |
SMG1 |
0.750 | -0.048 | 1 | 0.743 |
PKR |
0.749 | -0.056 | 1 | 0.771 |
DNAPK |
0.749 | -0.018 | 1 | 0.687 |
PAK1 |
0.749 | -0.048 | -2 | 0.815 |
TSSK2 |
0.749 | -0.095 | -5 | 0.781 |
PKCB |
0.749 | -0.050 | 2 | 0.760 |
IRE1 |
0.749 | -0.080 | 1 | 0.716 |
JNK1 |
0.749 | 0.087 | 1 | 0.702 |
PKCG |
0.749 | -0.043 | 2 | 0.754 |
DRAK1 |
0.749 | -0.008 | 1 | 0.766 |
AMPKA1 |
0.749 | -0.137 | -3 | 0.402 |
MAPKAPK3 |
0.748 | -0.135 | -3 | 0.312 |
RIPK1 |
0.748 | -0.130 | 1 | 0.725 |
GAK |
0.747 | 0.144 | 1 | 0.812 |
MST3 |
0.747 | 0.067 | 2 | 0.835 |
CDK12 |
0.747 | 0.038 | 1 | 0.701 |
GSK3B |
0.746 | 0.052 | 4 | 0.492 |
WNK3 |
0.746 | -0.221 | 1 | 0.734 |
VRK2 |
0.746 | -0.144 | 1 | 0.804 |
MEKK2 |
0.746 | 0.056 | 2 | 0.785 |
PKCA |
0.746 | -0.050 | 2 | 0.741 |
PLK2 |
0.746 | 0.025 | -3 | 0.501 |
DYRK1A |
0.746 | 0.012 | 1 | 0.771 |
AKT2 |
0.745 | -0.042 | -3 | 0.291 |
CAMK4 |
0.745 | -0.123 | -3 | 0.390 |
AURB |
0.745 | -0.003 | -2 | 0.699 |
CDK10 |
0.744 | 0.070 | 1 | 0.720 |
MAK |
0.744 | 0.080 | -2 | 0.817 |
DYRK1B |
0.743 | 0.034 | 1 | 0.735 |
DYRK3 |
0.742 | 0.024 | 1 | 0.755 |
AMPKA2 |
0.742 | -0.138 | -3 | 0.371 |
TLK1 |
0.742 | -0.007 | -2 | 0.804 |
IRE2 |
0.741 | -0.103 | 2 | 0.728 |
NIM1 |
0.741 | -0.154 | 3 | 0.823 |
TSSK1 |
0.741 | -0.135 | -3 | 0.404 |
PAK3 |
0.741 | -0.093 | -2 | 0.804 |
HIPK3 |
0.740 | 0.013 | 1 | 0.747 |
TAO3 |
0.740 | -0.017 | 1 | 0.739 |
PAK2 |
0.740 | -0.060 | -2 | 0.801 |
MNK2 |
0.740 | -0.086 | -2 | 0.801 |
PKCH |
0.740 | -0.082 | 2 | 0.728 |
ZAK |
0.740 | -0.057 | 1 | 0.698 |
MEK5 |
0.740 | -0.074 | 2 | 0.802 |
PKCZ |
0.739 | -0.096 | 2 | 0.764 |
PKG2 |
0.739 | -0.041 | -2 | 0.694 |
PAK6 |
0.739 | -0.035 | -2 | 0.745 |
PIM2 |
0.739 | -0.073 | -3 | 0.314 |
MNK1 |
0.739 | -0.081 | -2 | 0.800 |
CDK9 |
0.738 | 0.001 | 1 | 0.728 |
PINK1 |
0.737 | -0.148 | 1 | 0.790 |
QSK |
0.737 | -0.121 | 4 | 0.744 |
BRAF |
0.737 | -0.113 | -4 | 0.807 |
MST2 |
0.737 | 0.015 | 1 | 0.764 |
PHKG1 |
0.737 | -0.124 | -3 | 0.385 |
MEKK1 |
0.736 | -0.116 | 1 | 0.728 |
PRKD3 |
0.736 | -0.123 | -3 | 0.296 |
SGK3 |
0.735 | -0.088 | -3 | 0.326 |
NEK5 |
0.735 | -0.125 | 1 | 0.756 |
NEK2 |
0.734 | -0.188 | 2 | 0.780 |
QIK |
0.734 | -0.177 | -3 | 0.386 |
GCK |
0.734 | 0.016 | 1 | 0.774 |
PKACA |
0.734 | -0.031 | -2 | 0.657 |
NEK11 |
0.734 | -0.028 | 1 | 0.737 |
TAK1 |
0.734 | 0.076 | 1 | 0.750 |
MPSK1 |
0.734 | -0.016 | 1 | 0.728 |
PLK4 |
0.733 | -0.108 | 2 | 0.593 |
NUAK1 |
0.733 | -0.157 | -3 | 0.337 |
PERK |
0.733 | -0.124 | -2 | 0.798 |
CHAK1 |
0.733 | -0.159 | 2 | 0.713 |
CAMK1G |
0.733 | -0.101 | -3 | 0.333 |
BRSK1 |
0.732 | -0.140 | -3 | 0.343 |
MARK3 |
0.732 | -0.113 | 4 | 0.702 |
NEK8 |
0.731 | -0.069 | 2 | 0.792 |
DAPK3 |
0.731 | -0.020 | -3 | 0.374 |
SMMLCK |
0.731 | -0.067 | -3 | 0.371 |
DAPK1 |
0.730 | 0.005 | -3 | 0.381 |
SIK |
0.730 | -0.148 | -3 | 0.335 |
ERK7 |
0.730 | 0.002 | 2 | 0.532 |
MARK2 |
0.730 | -0.130 | 4 | 0.661 |
YANK3 |
0.730 | 0.102 | 2 | 0.390 |
MELK |
0.730 | -0.186 | -3 | 0.334 |
HRI |
0.729 | -0.179 | -2 | 0.819 |
MAPKAPK5 |
0.729 | -0.165 | -3 | 0.295 |
CHK1 |
0.728 | -0.191 | -3 | 0.348 |
AKT1 |
0.728 | -0.054 | -3 | 0.293 |
BMPR2_TYR |
0.728 | 0.285 | -1 | 0.755 |
HPK1 |
0.727 | 0.008 | 1 | 0.761 |
EEF2K |
0.726 | -0.010 | 3 | 0.821 |
CAMKK1 |
0.726 | -0.144 | -2 | 0.717 |
DCAMKL1 |
0.726 | -0.150 | -3 | 0.340 |
TTBK1 |
0.725 | -0.099 | 2 | 0.583 |
SNRK |
0.725 | -0.190 | 2 | 0.637 |
CDK6 |
0.724 | 0.030 | 1 | 0.705 |
MARK1 |
0.724 | -0.148 | 4 | 0.720 |
MAP2K6_TYR |
0.724 | 0.266 | -1 | 0.682 |
PKCE |
0.724 | -0.040 | 2 | 0.734 |
MOK |
0.723 | 0.013 | 1 | 0.782 |
PDHK4_TYR |
0.723 | 0.231 | 2 | 0.862 |
MINK |
0.723 | -0.036 | 1 | 0.735 |
BRSK2 |
0.723 | -0.188 | -3 | 0.347 |
LKB1 |
0.723 | -0.138 | -3 | 0.417 |
TNIK |
0.722 | -0.048 | 3 | 0.866 |
PKCT |
0.722 | -0.103 | 2 | 0.735 |
TAO2 |
0.722 | -0.115 | 2 | 0.839 |
PDHK1_TYR |
0.722 | 0.246 | -1 | 0.714 |
PDK1 |
0.722 | -0.109 | 1 | 0.717 |
CAMKK2 |
0.722 | -0.150 | -2 | 0.712 |
SSTK |
0.722 | -0.104 | 4 | 0.729 |
WNK4 |
0.721 | -0.178 | -2 | 0.835 |
MST1 |
0.721 | -0.056 | 1 | 0.741 |
TXK |
0.721 | 0.186 | 1 | 0.822 |
PDHK3_TYR |
0.721 | 0.114 | 4 | 0.840 |
AKT3 |
0.720 | -0.046 | -3 | 0.253 |
IRAK4 |
0.720 | -0.163 | 1 | 0.707 |
ALPHAK3 |
0.720 | 0.095 | -1 | 0.616 |
OSR1 |
0.719 | 0.027 | 2 | 0.780 |
P70S6K |
0.719 | -0.126 | -3 | 0.281 |
CDK4 |
0.719 | 0.022 | 1 | 0.690 |
PKCI |
0.719 | -0.092 | 2 | 0.736 |
TTK |
0.719 | 0.056 | -2 | 0.816 |
CAMK1D |
0.719 | -0.118 | -3 | 0.266 |
SGK1 |
0.719 | -0.062 | -3 | 0.245 |
SYK |
0.718 | 0.296 | -1 | 0.769 |
KHS2 |
0.718 | -0.008 | 1 | 0.758 |
FYN |
0.718 | 0.244 | -1 | 0.751 |
HGK |
0.717 | -0.095 | 3 | 0.864 |
PTK2 |
0.717 | 0.272 | -1 | 0.798 |
VRK1 |
0.717 | -0.108 | 2 | 0.818 |
PAK5 |
0.717 | -0.062 | -2 | 0.697 |
MAP3K15 |
0.717 | -0.102 | 1 | 0.684 |
DCAMKL2 |
0.716 | -0.155 | -3 | 0.340 |
PHKG2 |
0.716 | -0.142 | -3 | 0.343 |
SLK |
0.716 | -0.079 | -2 | 0.678 |
MEKK6 |
0.716 | -0.141 | 1 | 0.735 |
IRAK1 |
0.715 | -0.213 | -1 | 0.512 |
PAK4 |
0.715 | -0.043 | -2 | 0.709 |
MAP2K4_TYR |
0.715 | 0.087 | -1 | 0.661 |
KHS1 |
0.715 | -0.049 | 1 | 0.734 |
NEK4 |
0.715 | -0.170 | 1 | 0.721 |
EPHA6 |
0.713 | 0.134 | -1 | 0.739 |
ROCK2 |
0.712 | -0.063 | -3 | 0.352 |
LCK |
0.712 | 0.178 | -1 | 0.731 |
MRCKB |
0.712 | -0.067 | -3 | 0.309 |
BLK |
0.712 | 0.171 | -1 | 0.731 |
LRRK2 |
0.710 | -0.182 | 2 | 0.812 |
EPHB4 |
0.710 | 0.076 | -1 | 0.668 |
CHK2 |
0.710 | -0.112 | -3 | 0.238 |
NEK1 |
0.710 | -0.195 | 1 | 0.717 |
TESK1_TYR |
0.709 | -0.031 | 3 | 0.909 |
MRCKA |
0.709 | -0.082 | -3 | 0.318 |
FGR |
0.709 | 0.110 | 1 | 0.816 |
DMPK1 |
0.709 | -0.032 | -3 | 0.334 |
SBK |
0.708 | -0.088 | -3 | 0.196 |
MAP2K7_TYR |
0.708 | -0.045 | 2 | 0.832 |
PBK |
0.707 | -0.064 | 1 | 0.750 |
ABL2 |
0.707 | 0.065 | -1 | 0.613 |
LOK |
0.707 | -0.144 | -2 | 0.729 |
PKN1 |
0.706 | -0.122 | -3 | 0.283 |
HASPIN |
0.706 | -0.037 | -1 | 0.464 |
FLT1 |
0.706 | 0.174 | -1 | 0.720 |
HCK |
0.706 | 0.116 | -1 | 0.702 |
YES1 |
0.706 | 0.046 | -1 | 0.649 |
STK33 |
0.705 | -0.129 | 2 | 0.584 |
BUB1 |
0.705 | -0.067 | -5 | 0.714 |
YANK2 |
0.705 | 0.114 | 2 | 0.410 |
CAMK1A |
0.705 | -0.111 | -3 | 0.250 |
FER |
0.704 | 0.023 | 1 | 0.826 |
EPHA4 |
0.704 | 0.056 | 2 | 0.768 |
PINK1_TYR |
0.704 | -0.030 | 1 | 0.771 |
PKMYT1_TYR |
0.704 | -0.083 | 3 | 0.889 |
INSRR |
0.704 | 0.076 | 3 | 0.778 |
RIPK2 |
0.703 | -0.193 | 1 | 0.653 |
YSK1 |
0.703 | -0.131 | 2 | 0.785 |
MEK2 |
0.703 | -0.241 | 2 | 0.778 |
EPHB2 |
0.702 | 0.066 | -1 | 0.667 |
ABL1 |
0.702 | 0.044 | -1 | 0.597 |
SRMS |
0.701 | 0.038 | 1 | 0.812 |
BMX |
0.701 | 0.068 | -1 | 0.594 |
ZAP70 |
0.701 | 0.211 | -1 | 0.673 |
EPHB1 |
0.701 | 0.037 | 1 | 0.806 |
ITK |
0.700 | 0.044 | -1 | 0.637 |
KIT |
0.700 | 0.061 | 3 | 0.827 |
RET |
0.698 | -0.071 | 1 | 0.724 |
CSF1R |
0.698 | -0.006 | 3 | 0.822 |
MET |
0.698 | 0.099 | 3 | 0.816 |
EPHB3 |
0.698 | 0.029 | -1 | 0.660 |
MYO3A |
0.698 | -0.065 | 1 | 0.718 |
JAK3 |
0.697 | 0.043 | 1 | 0.701 |
ROCK1 |
0.697 | -0.074 | -3 | 0.321 |
BIKE |
0.696 | -0.030 | 1 | 0.707 |
SRC |
0.696 | 0.105 | -1 | 0.692 |
LYN |
0.695 | 0.083 | 3 | 0.752 |
KDR |
0.695 | 0.045 | 3 | 0.790 |
MYO3B |
0.695 | -0.104 | 2 | 0.801 |
EPHA8 |
0.693 | 0.087 | -1 | 0.713 |
ASK1 |
0.693 | -0.137 | 1 | 0.667 |
JAK2 |
0.693 | -0.079 | 1 | 0.715 |
ROS1 |
0.692 | -0.092 | 3 | 0.796 |
TYRO3 |
0.692 | -0.105 | 3 | 0.821 |
EPHA7 |
0.692 | 0.028 | 2 | 0.761 |
LIMK2_TYR |
0.692 | -0.161 | -3 | 0.413 |
ERBB4 |
0.692 | 0.150 | 1 | 0.658 |
ERBB2 |
0.692 | 0.044 | 1 | 0.701 |
MST1R |
0.692 | -0.094 | 3 | 0.837 |
PKG1 |
0.692 | -0.090 | -2 | 0.613 |
TEC |
0.691 | -0.029 | -1 | 0.542 |
STLK3 |
0.690 | -0.093 | 1 | 0.668 |
CRIK |
0.690 | -0.096 | -3 | 0.288 |
TYK2 |
0.690 | -0.143 | 1 | 0.718 |
FRK |
0.690 | 0.050 | -1 | 0.703 |
EPHA5 |
0.690 | 0.042 | 2 | 0.758 |
FGFR2 |
0.689 | -0.044 | 3 | 0.828 |
MERTK |
0.688 | -0.034 | 3 | 0.817 |
EPHA3 |
0.688 | -0.006 | 2 | 0.732 |
FGFR3 |
0.687 | 0.020 | 3 | 0.799 |
LIMK1_TYR |
0.687 | -0.232 | 2 | 0.820 |
EGFR |
0.687 | 0.037 | 1 | 0.609 |
MATK |
0.686 | -0.004 | -1 | 0.555 |
FLT3 |
0.686 | -0.060 | 3 | 0.821 |
EPHA2 |
0.684 | 0.071 | -1 | 0.694 |
FGFR4 |
0.684 | 0.024 | -1 | 0.609 |
BTK |
0.684 | -0.097 | -1 | 0.568 |
DDR1 |
0.684 | -0.176 | 4 | 0.743 |
TAO1 |
0.682 | -0.158 | 1 | 0.649 |
NEK3 |
0.682 | -0.271 | 1 | 0.669 |
NTRK1 |
0.682 | -0.091 | -1 | 0.613 |
TEK |
0.681 | -0.098 | 3 | 0.768 |
PTK2B |
0.680 | -0.027 | -1 | 0.560 |
TNK2 |
0.680 | -0.111 | 3 | 0.788 |
INSR |
0.679 | -0.054 | 3 | 0.755 |
PDGFRB |
0.679 | -0.152 | 3 | 0.829 |
WEE1_TYR |
0.679 | -0.061 | -1 | 0.541 |
NTRK3 |
0.679 | -0.068 | -1 | 0.586 |
FLT4 |
0.678 | -0.051 | 3 | 0.793 |
AAK1 |
0.678 | -0.015 | 1 | 0.626 |
CSK |
0.677 | -0.034 | 2 | 0.757 |
JAK1 |
0.677 | -0.110 | 1 | 0.664 |
LTK |
0.676 | -0.111 | 3 | 0.775 |
FGFR1 |
0.676 | -0.128 | 3 | 0.793 |
PTK6 |
0.676 | -0.154 | -1 | 0.526 |
ALK |
0.676 | -0.118 | 3 | 0.743 |
EPHA1 |
0.674 | -0.074 | 3 | 0.793 |
IGF1R |
0.674 | 0.001 | 3 | 0.702 |
AXL |
0.674 | -0.155 | 3 | 0.806 |
NTRK2 |
0.671 | -0.150 | 3 | 0.782 |
TNNI3K_TYR |
0.670 | -0.154 | 1 | 0.730 |
NEK10_TYR |
0.670 | -0.182 | 1 | 0.593 |
TNK1 |
0.669 | -0.193 | 3 | 0.818 |
PDGFRA |
0.667 | -0.219 | 3 | 0.824 |
DDR2 |
0.667 | -0.100 | 3 | 0.756 |
FES |
0.664 | -0.014 | -1 | 0.554 |
MUSK |
0.659 | -0.096 | 1 | 0.611 |