Motif 8 (n=106)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S229 | ochoa | Snf2 related CREBBP activator protein | None |
| A1A5D9 | BICDL2 | S351 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A5YM69 | ARHGEF35 | S445 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| A6H8Y1 | BDP1 | S938 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NKT7 | RGPD3 | S1232 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| B7U540 | KCNJ18 | S405 | ochoa | Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:20074522, ECO:0000269|PubMed:27008341}. |
| O14526 | FCHO1 | S295 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14715 | RGPD8 | S1231 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15027 | SEC16A | S1601 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15173 | PGRMC2 | S90 | ochoa | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}. |
| O43164 | PJA2 | S216 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43182 | ARHGAP6 | S927 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43491 | EPB41L2 | S386 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43765 | SGTA | S77 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. |
| O60566 | BUB1B | S288 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60711 | LPXN | S23 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
| O75182 | SIN3B | S640 | ochoa | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| O75369 | FLNB | S2227 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75369 | FLNB | S2418 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75427 | LRCH4 | S380 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O94988 | FAM13A | S555 | ochoa | Protein FAM13A | None |
| P04844 | RPN2 | S516 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:F1PCT7, ECO:0000269|PubMed:31831667}. |
| P08670 | VIM | S299 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P0DJD0 | RGPD1 | S1216 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1224 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P12270 | TPR | S522 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P17480 | UBTF | S433 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P19022 | CDH2 | S788 | ochoa | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) | Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. {ECO:0000250|UniProtKB:P10288, ECO:0000250|UniProtKB:P15116, ECO:0000269|PubMed:31585109}. |
| P21333 | FLNA | S1899 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2081 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P31751 | AKT2 | S447 | ochoa | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta) | Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through the phosphorylation of a range of downstream substrates. Over 100 substrates have been reported so far, although for most of them, the precise AKT kinase catalyzing the reaction was not specified. AKT regulates glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1). AKT mediates the antiapoptotic effects of IGF1. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development (PubMed:21432781, PubMed:21620960). In response to lysophosphatidic acid stimulation, inhibits the ciliogenesis cascade. In this context, phosphorylates WDR44, hence stabilizing its interaction with Rab11 and preventing the formation of the ciliogenic Rab11-FIP3-RAB3IP complex. Also phosphorylates RAB3IP/Rabin8, thus may affect RAB3IP guanine nucleotide exchange factor (GEF) activity toward Rab8, which is important for cilia growth (PubMed:31204173). Phosphorylates PKP1, facilitating its interaction with YWHAG and translocation to the nucleus, ultimately resulting in a reduction in keratinocyte intercellular adhesion (By similarity). Phosphorylation of PKP1 increases PKP1 protein stability, translocation to the cytoplasm away from desmosome plaques and PKP1-driven cap-dependent translation (PubMed:23444369). {ECO:0000250|UniProtKB:Q60823, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:31204173, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.; FUNCTION: Several AKT2-specific substrates have been identified, including ANKRD2, C2CD5, CLK2 and PITX2. May play a role in myoblast differentiation. In this context, may act through PITX2 phosphorylation. Unphosphorylated PITX2 associates with an ELAVL1/HuR-containing complex, which stabilizes CCND1 cyclin mRNA, ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation (By similarity). Also involved in the negative regulation of myogenesis in response to stress conditions. In this context, acts by phosphorylating ANKRD2 (By similarity). May also be a key regulator of glucose uptake. Regulates insulin-stimulated glucose transport by the increase of glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. In this context, acts by phosphorylating C2CD5/CDP138 on 'Ser-197' in insulin-stimulated adipocytes (By similarity). Through the phosphorylation of CLK2 on 'Thr-343', involved in insulin-regulated suppression of hepatic gluconeogenesis (By similarity). {ECO:0000250|UniProtKB:Q60823}. |
| P33241 | LSP1 | S139 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P35237 | SERPINB6 | S151 | ochoa | Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}. |
| P49327 | FASN | S1129 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49327 | FASN | S2417 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S2207 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S3059 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52292 | KPNA2 | S105 | psp | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P78413 | IRX4 | S258 | ochoa | Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) | Likely to be an important mediator of ventricular differentiation during cardiac development. |
| P82987 | ADAMTSL3 | S631 | ochoa | ADAMTS-like protein 3 (ADAMTSL-3) (Punctin-2) | None |
| Q00839 | HNRNPU | S59 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q03188 | CENPC | S610 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q06787 | FMR1 | S511 | ochoa|psp | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) | Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:12417522, PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522, PubMed:30765518, PubMed:31439799). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (PubMed:30765518). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11157796, PubMed:11532944, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:11157796, PubMed:11719189, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548, PubMed:7692601). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529, PubMed:7692601). Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export (PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:12950170, PubMed:15381419, PubMed:7688265, PubMed:7781595, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (PubMed:39106863). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:11157796, ECO:0000269|PubMed:11532944, ECO:0000269|PubMed:11719189, ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:12594214, ECO:0000269|PubMed:12927206, ECO:0000269|PubMed:12950170, ECO:0000269|PubMed:14703574, ECO:0000269|PubMed:15282548, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15805463, ECO:0000269|PubMed:16631377, ECO:0000269|PubMed:17057366, ECO:0000269|PubMed:17417632, ECO:0000269|PubMed:18579868, ECO:0000269|PubMed:18653529, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:19097999, ECO:0000269|PubMed:19166269, ECO:0000269|PubMed:20512134, ECO:0000269|PubMed:23235829, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:24448548, ECO:0000269|PubMed:24813610, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:25561520, ECO:0000269|PubMed:25692235, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:31753916, ECO:0000269|PubMed:39106863, ECO:0000269|PubMed:7688265, ECO:0000269|PubMed:7692601, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8156595}.; FUNCTION: [Isoform 10]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: [Isoform 6]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components. {ECO:0000269|PubMed:24514761}. |
| Q07864 | POLE | S1204 | ochoa | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
| Q12774 | ARHGEF5 | S445 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12873 | CHD3 | S1819 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q13033 | STRN3 | S168 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q13127 | REST | S750 | ochoa | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q13127 | REST | S766 | ochoa | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q13568 | IRF5 | S435 | psp | Interferon regulatory factor 5 (IRF-5) | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}. |
| Q14315 | FLNC | S1893 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S2348 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14500 | KCNJ12 | S405 | ochoa | ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12) | Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:12417321, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}. |
| Q15058 | KIF14 | S1186 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q16625 | OCLN | S40 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q32MK0 | MYLK3 | S401 | ochoa | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q58WW2 | DCAF6 | S478 | ochoa | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q5H9R7 | PPP6R3 | S825 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5S007 | LRRK2 | S1292 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5VYK3 | ECPAS | S1333 | ochoa | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}. |
| Q6IBW4 | NCAPH2 | S492 | ochoa|psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6IQ23 | PLEKHA7 | S994 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NZI2 | CAVIN1 | S25 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6W2J9 | BCOR | S1410 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZMQ8 | AATK | S495 | ochoa | Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) | May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}. |
| Q6ZRS2 | SRCAP | S248 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7L8J4 | SH3BP5L | S49 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
| Q7Z3B4 | NUP54 | S289 | ochoa | Nucleoporin p54 (54 kDa nucleoporin) | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70582}. |
| Q7Z3J3 | RGPD4 | S1232 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z4S6 | KIF21A | S1212 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6J8 | UBE3D | S184 | ochoa | E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome (PubMed:15749827). Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site (PubMed:39032490). {ECO:0000269|PubMed:15749827, ECO:0000269|PubMed:39032490}. |
| Q7Z7C8 | TAF8 | S280 | ochoa | Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250|UniProtKB:Q9EQH4, ECO:0000269|PubMed:14580349, ECO:0000269|PubMed:33795473}. |
| Q86SQ7 | SDCCAG8 | S51 | ochoa | Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) | Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}. |
| Q86X02 | CDR2L | S419 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q8IWE5 | PLEKHM2 | S532 | ochoa | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) | Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}. |
| Q8IX01 | SUGP2 | S603 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8N2Y8 | RUSC2 | S911 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8N5C1 | CALHM5 | S238 | ochoa | Calcium homeostasis modulator protein 5 (Protein FAM26E) | May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids. {ECO:0000269|PubMed:33298887}. |
| Q8TEA8 | DTD1 | S182 | psp | D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) | Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}. |
| Q92616 | GCN1 | S1491 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q92817 | EVPL | S906 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
| Q96F46 | IL17RA | S554 | ochoa|psp | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
| Q96RT7 | TUBGCP6 | S1381 | ochoa | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RY5 | CRAMP1 | S556 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99459 | CDC5L | S339 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99543 | DNAJC2 | S541 | ochoa | DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed] | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}. |
| Q99666 | RGPD5 | S1231 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99956 | DUSP9 | S361 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q9BRT9 | GINS4 | S123 | ochoa | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:28414293, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| Q9H329 | EPB41L4B | S254 | ochoa | Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}. |
| Q9H5U6 | ZCCHC4 | S381 | ochoa | rRNA N(6)-adenosine-methyltransferase ZCCHC4 (EC 2.1.1.-) (Zinc finger CCHC domain-containing protein 4) | rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31695039, PubMed:31799605). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605). {ECO:0000269|PubMed:30531910, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:31695039, ECO:0000269|PubMed:31799605}. |
| Q9H6Z4 | RANBP3 | S35 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9HCG7 | GBA2 | S47 | ochoa | Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase) | Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (PubMed:17105727, PubMed:30308956, PubMed:32144204). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties (PubMed:32144204). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (Probable). May play a role in the metabolism of bile acids (PubMed:11489889, PubMed:17080196, PubMed:9111029). Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:17080196, PubMed:9111029). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (PubMed:32144204). {ECO:0000250|UniProtKB:Q69ZF3, ECO:0000269|PubMed:11489889, ECO:0000269|PubMed:17080196, ECO:0000269|PubMed:17105727, ECO:0000269|PubMed:30308956, ECO:0000269|PubMed:32144204, ECO:0000269|PubMed:9111029, ECO:0000305|PubMed:32144204}. |
| Q9NXH9 | TRMT1 | S517 | ochoa | tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA methyltransferase 1) (hTRM1) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) | Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718). {ECO:0000269|PubMed:10982862, ECO:0000269|PubMed:28784718, ECO:0000269|PubMed:37204604, ECO:0000269|PubMed:39786990}. |
| Q9UBS0 | RPS6KB2 | S24 | ochoa | Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) | Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
| Q9UBT2 | UBA2 | S507 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
| Q9UPN3 | MACF1 | S3692 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPV0 | CEP164 | S588 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y2L9 | LRCH1 | S370 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81) | Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}. |
| Q9NR30 | DDX21 | S706 | Sugiyama | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| P07948 | LYN | S457 | Sugiyama | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| Q03135 | CAV1 | S88 | SIGNOR|ELM|iPTMNet | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| Q13057 | COASY | S507 | Sugiyama | Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] | Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:24360804}. |
| O00469 | PLOD2 | S367 | Sugiyama | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2) | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250|UniProtKB:P24802}. |
| P50570 | DNM2 | S357 | Sugiyama | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
| Q6GYQ0 | RALGAPA1 | S1279 | Sugiyama | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000067 | 4.173 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000335 | 3.476 |
| R-HSA-1640170 | Cell Cycle | 0.000185 | 3.732 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.000322 | 3.492 |
| R-HSA-68886 | M Phase | 0.000574 | 3.241 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.002331 | 2.632 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.003326 | 2.478 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.002178 | 2.662 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.002352 | 2.629 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.002352 | 2.629 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.002727 | 2.564 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.002727 | 2.564 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.002927 | 2.534 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.003355 | 2.474 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.004319 | 2.365 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.004584 | 2.339 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.003818 | 2.418 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.002927 | 2.534 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.001506 | 2.822 |
| R-HSA-68877 | Mitotic Prometaphase | 0.003971 | 2.401 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.003136 | 2.504 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.004584 | 2.339 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.004584 | 2.339 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.004064 | 2.391 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.004486 | 2.348 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.001918 | 2.717 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.004170 | 2.380 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.001417 | 2.848 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.004858 | 2.314 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.004634 | 2.334 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.005606 | 2.251 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.006377 | 2.195 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.006525 | 2.185 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.006710 | 2.173 |
| R-HSA-9679506 | SARS-CoV Infections | 0.007494 | 2.125 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.008077 | 2.093 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.008077 | 2.093 |
| R-HSA-913531 | Interferon Signaling | 0.007833 | 2.106 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.008522 | 2.069 |
| R-HSA-191859 | snRNP Assembly | 0.012006 | 1.921 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.012006 | 1.921 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.011073 | 1.956 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.011622 | 1.935 |
| R-HSA-72306 | tRNA processing | 0.011003 | 1.958 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.012983 | 1.887 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.013488 | 1.870 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.013607 | 1.866 |
| R-HSA-68875 | Mitotic Prophase | 0.015081 | 1.822 |
| R-HSA-3371556 | Cellular response to heat stress | 0.015455 | 1.811 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.015728 | 1.803 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.016610 | 1.780 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.017981 | 1.745 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.018725 | 1.728 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.019779 | 1.704 |
| R-HSA-380287 | Centrosome maturation | 0.021069 | 1.676 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.019779 | 1.704 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.019151 | 1.718 |
| R-HSA-446728 | Cell junction organization | 0.018975 | 1.722 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.022867 | 1.641 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.023089 | 1.637 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.025491 | 1.594 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.025941 | 1.586 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.026847 | 1.571 |
| R-HSA-68882 | Mitotic Anaphase | 0.025875 | 1.587 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.026285 | 1.580 |
| R-HSA-6807070 | PTEN Regulation | 0.024675 | 1.608 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.026847 | 1.571 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.028902 | 1.539 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.028973 | 1.538 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.028973 | 1.538 |
| R-HSA-1296053 | Classical Kir channels | 0.034483 | 1.462 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.031366 | 1.504 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.031086 | 1.507 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.032554 | 1.487 |
| R-HSA-69242 | S Phase | 0.030022 | 1.523 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.029645 | 1.528 |
| R-HSA-1500931 | Cell-Cell communication | 0.031600 | 1.500 |
| R-HSA-8939211 | ESR-mediated signaling | 0.035377 | 1.451 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.041237 | 1.385 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.043555 | 1.361 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.043555 | 1.361 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.043851 | 1.358 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.041237 | 1.385 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.039902 | 1.399 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.040286 | 1.395 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.042828 | 1.368 |
| R-HSA-70171 | Glycolysis | 0.043851 | 1.358 |
| R-HSA-109581 | Apoptosis | 0.038577 | 1.414 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.042888 | 1.368 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.045225 | 1.345 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.054605 | 1.263 |
| R-HSA-165158 | Activation of AKT2 | 0.047945 | 1.319 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.054605 | 1.263 |
| R-HSA-165160 | PDE3B signalling | 0.054605 | 1.263 |
| R-HSA-109703 | PKB-mediated events | 0.054605 | 1.263 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.048635 | 1.313 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.054605 | 1.263 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.054068 | 1.267 |
| R-HSA-69239 | Synthesis of DNA | 0.051941 | 1.284 |
| R-HSA-69275 | G2/M Transition | 0.056989 | 1.244 |
| R-HSA-168255 | Influenza Infection | 0.051429 | 1.289 |
| R-HSA-75153 | Apoptotic execution phase | 0.055724 | 1.254 |
| R-HSA-162582 | Signal Transduction | 0.047856 | 1.320 |
| R-HSA-211000 | Gene Silencing by RNA | 0.051941 | 1.284 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.057338 | 1.242 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.058635 | 1.232 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.059396 | 1.226 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.059396 | 1.226 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.060178 | 1.221 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.061220 | 1.213 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.061220 | 1.213 |
| R-HSA-9766229 | Degradation of CDH1 | 0.061263 | 1.213 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.066981 | 1.174 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.068925 | 1.162 |
| R-HSA-190873 | Gap junction degradation | 0.080789 | 1.093 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.072869 | 1.137 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.074868 | 1.126 |
| R-HSA-196025 | Formation of annular gap junctions | 0.074311 | 1.129 |
| R-HSA-176974 | Unwinding of DNA | 0.080789 | 1.093 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.072869 | 1.137 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.070101 | 1.154 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.080789 | 1.093 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.071699 | 1.144 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.080789 | 1.093 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.074311 | 1.129 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.083035 | 1.081 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.068925 | 1.162 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.074868 | 1.126 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.076884 | 1.114 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.080789 | 1.093 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.074311 | 1.129 |
| R-HSA-69206 | G1/S Transition | 0.076292 | 1.118 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.083035 | 1.081 |
| R-HSA-70326 | Glucose metabolism | 0.065321 | 1.185 |
| R-HSA-5357801 | Programmed Cell Death | 0.074575 | 1.127 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.087222 | 1.059 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.106253 | 0.974 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.106253 | 0.974 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.124892 | 0.903 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.089331 | 1.049 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.089331 | 1.049 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.095763 | 1.019 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.106766 | 0.972 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.118089 | 0.928 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.106766 | 0.972 |
| R-HSA-68952 | DNA replication initiation | 0.087222 | 1.059 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.118722 | 0.925 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.106766 | 0.972 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.106766 | 0.972 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.118722 | 0.925 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.112510 | 0.949 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.104539 | 0.981 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.109006 | 0.963 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.099954 | 1.000 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.087217 | 1.059 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.093610 | 1.029 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.124892 | 0.903 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.087222 | 1.059 |
| R-HSA-210990 | PECAM1 interactions | 0.093610 | 1.029 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.093610 | 1.029 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.124892 | 0.903 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.122628 | 0.911 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.106253 | 0.974 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.095654 | 1.019 |
| R-HSA-69306 | DNA Replication | 0.119574 | 0.922 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.109006 | 0.963 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.112510 | 0.949 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.104539 | 0.981 |
| R-HSA-8983711 | OAS antiviral response | 0.106253 | 0.974 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.122700 | 0.911 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.109006 | 0.963 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.111259 | 0.954 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.093610 | 1.029 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.089331 | 1.049 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.093460 | 1.029 |
| R-HSA-162906 | HIV Infection | 0.096722 | 1.014 |
| R-HSA-418990 | Adherens junctions interactions | 0.087319 | 1.059 |
| R-HSA-421270 | Cell-cell junction organization | 0.123982 | 0.907 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.120389 | 0.919 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.115047 | 0.939 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.103309 | 0.986 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.083837 | 1.077 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.119228 | 0.924 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.118057 | 0.928 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.125022 | 0.903 |
| R-HSA-9610379 | HCMV Late Events | 0.125711 | 0.901 |
| R-HSA-162587 | HIV Life Cycle | 0.125711 | 0.901 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.127354 | 0.895 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.130038 | 0.886 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.137103 | 0.863 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.149145 | 0.826 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.166897 | 0.778 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.172732 | 0.763 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.206903 | 0.684 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.217979 | 0.662 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.217979 | 0.662 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.239674 | 0.620 |
| R-HSA-390522 | Striated Muscle Contraction | 0.245004 | 0.611 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.153641 | 0.813 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.172732 | 0.763 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.178527 | 0.748 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.206903 | 0.684 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.161021 | 0.793 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.217979 | 0.662 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.223460 | 0.651 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.260772 | 0.584 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.137103 | 0.863 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.195671 | 0.708 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.195671 | 0.708 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.195671 | 0.708 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.250296 | 0.602 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.178527 | 0.748 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.178527 | 0.748 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.260772 | 0.584 |
| R-HSA-525793 | Myogenesis | 0.201306 | 0.696 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.172732 | 0.763 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.206903 | 0.684 |
| R-HSA-209968 | Thyroxine biosynthesis | 0.217979 | 0.662 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.131019 | 0.883 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.189996 | 0.721 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.228902 | 0.640 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.149145 | 0.826 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.155104 | 0.809 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.234307 | 0.630 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.234307 | 0.630 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.255552 | 0.593 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.255552 | 0.593 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.136786 | 0.864 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.201306 | 0.696 |
| R-HSA-196783 | Coenzyme A biosynthesis | 0.137103 | 0.863 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.178527 | 0.748 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.184281 | 0.735 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.260772 | 0.584 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.260772 | 0.584 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.260772 | 0.584 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.217979 | 0.662 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.223460 | 0.651 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.250296 | 0.602 |
| R-HSA-203615 | eNOS activation | 0.250296 | 0.602 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.212460 | 0.673 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.245004 | 0.611 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.250296 | 0.602 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.250296 | 0.602 |
| R-HSA-169911 | Regulation of Apoptosis | 0.255552 | 0.593 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.260772 | 0.584 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.143145 | 0.844 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.184281 | 0.735 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.206190 | 0.686 |
| R-HSA-9609690 | HCMV Early Events | 0.192508 | 0.716 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.141558 | 0.849 |
| R-HSA-73886 | Chromosome Maintenance | 0.244794 | 0.611 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.166897 | 0.778 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.206903 | 0.684 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.132494 | 0.878 |
| R-HSA-8953854 | Metabolism of RNA | 0.147767 | 0.830 |
| R-HSA-69190 | DNA strand elongation | 0.234307 | 0.630 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.137103 | 0.863 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.185893 | 0.731 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.221376 | 0.655 |
| R-HSA-210991 | Basigin interactions | 0.166897 | 0.778 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.201306 | 0.696 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.237035 | 0.625 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.208745 | 0.680 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.189996 | 0.721 |
| R-HSA-111933 | Calmodulin induced events | 0.260772 | 0.584 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.169845 | 0.770 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.178527 | 0.748 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.217979 | 0.662 |
| R-HSA-111997 | CaM pathway | 0.260772 | 0.584 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.229292 | 0.640 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.229292 | 0.640 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.184281 | 0.735 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.245004 | 0.611 |
| R-HSA-194138 | Signaling by VEGF | 0.257746 | 0.589 |
| R-HSA-74160 | Gene expression (Transcription) | 0.229025 | 0.640 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.239674 | 0.620 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.201091 | 0.697 |
| R-HSA-163560 | Triglyceride catabolism | 0.260772 | 0.584 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.223460 | 0.651 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.239620 | 0.620 |
| R-HSA-9824446 | Viral Infection Pathways | 0.182328 | 0.739 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.260772 | 0.584 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.152992 | 0.815 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.152992 | 0.815 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.203639 | 0.691 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.203639 | 0.691 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.192508 | 0.716 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.180865 | 0.743 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.225033 | 0.648 |
| R-HSA-449147 | Signaling by Interleukins | 0.169287 | 0.771 |
| R-HSA-5619102 | SLC transporter disorders | 0.141535 | 0.849 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.265524 | 0.576 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.265955 | 0.575 |
| R-HSA-4641258 | Degradation of DVL | 0.265955 | 0.575 |
| R-HSA-4641257 | Degradation of AXIN | 0.265955 | 0.575 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.265955 | 0.575 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.265955 | 0.575 |
| R-HSA-9843745 | Adipogenesis | 0.275895 | 0.559 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.276214 | 0.559 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.276214 | 0.559 |
| R-HSA-69541 | Stabilization of p53 | 0.276214 | 0.559 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.276214 | 0.559 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.281289 | 0.551 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.281289 | 0.551 |
| R-HSA-9646399 | Aggrephagy | 0.281289 | 0.551 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.281289 | 0.551 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.286330 | 0.543 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.286330 | 0.543 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.286330 | 0.543 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.286330 | 0.543 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.286330 | 0.543 |
| R-HSA-9694548 | Maturation of spike protein | 0.286330 | 0.543 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.286330 | 0.543 |
| R-HSA-9607240 | FLT3 Signaling | 0.286330 | 0.543 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.286457 | 0.543 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.291336 | 0.536 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.291336 | 0.536 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.291336 | 0.536 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.291336 | 0.536 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.291336 | 0.536 |
| R-HSA-163685 | Integration of energy metabolism | 0.291439 | 0.535 |
| R-HSA-9609646 | HCMV Infection | 0.294595 | 0.531 |
| R-HSA-991365 | Activation of GABAB receptors | 0.296306 | 0.528 |
| R-HSA-977444 | GABA B receptor activation | 0.296306 | 0.528 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.296306 | 0.528 |
| R-HSA-111996 | Ca-dependent events | 0.296306 | 0.528 |
| R-HSA-165159 | MTOR signalling | 0.296306 | 0.528 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.301243 | 0.521 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.301243 | 0.521 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.306144 | 0.514 |
| R-HSA-190828 | Gap junction trafficking | 0.306144 | 0.514 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.306144 | 0.514 |
| R-HSA-9907900 | Proteasome assembly | 0.306144 | 0.514 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.306144 | 0.514 |
| R-HSA-69236 | G1 Phase | 0.306144 | 0.514 |
| R-HSA-2262752 | Cellular responses to stress | 0.306261 | 0.514 |
| R-HSA-774815 | Nucleosome assembly | 0.311012 | 0.507 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.311012 | 0.507 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.311012 | 0.507 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.311012 | 0.507 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.311012 | 0.507 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.311012 | 0.507 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.311012 | 0.507 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.311012 | 0.507 |
| R-HSA-9824272 | Somitogenesis | 0.311012 | 0.507 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.311012 | 0.507 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.312098 | 0.506 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.314673 | 0.502 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.315846 | 0.501 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.315846 | 0.501 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.320646 | 0.494 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.320646 | 0.494 |
| R-HSA-437239 | Recycling pathway of L1 | 0.320646 | 0.494 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.322385 | 0.492 |
| R-HSA-166520 | Signaling by NTRKs | 0.324951 | 0.488 |
| R-HSA-9758941 | Gastrulation | 0.327514 | 0.485 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.329049 | 0.483 |
| R-HSA-199991 | Membrane Trafficking | 0.329456 | 0.482 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.330076 | 0.481 |
| R-HSA-73893 | DNA Damage Bypass | 0.330147 | 0.481 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.330147 | 0.481 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.330147 | 0.481 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.330147 | 0.481 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.332634 | 0.478 |
| R-HSA-109704 | PI3K Cascade | 0.334848 | 0.475 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.334848 | 0.475 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.337743 | 0.471 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.339516 | 0.469 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.339516 | 0.469 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.339516 | 0.469 |
| R-HSA-73887 | Death Receptor Signaling | 0.340293 | 0.468 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.344152 | 0.463 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.344152 | 0.463 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.344152 | 0.463 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.344152 | 0.463 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.344152 | 0.463 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.344152 | 0.463 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.348755 | 0.457 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.348755 | 0.457 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.348755 | 0.457 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.350464 | 0.455 |
| R-HSA-877300 | Interferon gamma signaling | 0.352999 | 0.452 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.353327 | 0.452 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.355530 | 0.449 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.355857 | 0.449 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.362374 | 0.441 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 0.362374 | 0.441 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.362374 | 0.441 |
| R-HSA-112399 | IRS-mediated signalling | 0.366851 | 0.436 |
| R-HSA-5621480 | Dectin-2 family | 0.366851 | 0.436 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.371296 | 0.430 |
| R-HSA-180786 | Extension of Telomeres | 0.375711 | 0.425 |
| R-HSA-8979227 | Triglyceride metabolism | 0.375711 | 0.425 |
| R-HSA-186712 | Regulation of beta-cell development | 0.375711 | 0.425 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.380095 | 0.420 |
| R-HSA-977443 | GABA receptor activation | 0.380095 | 0.420 |
| R-HSA-983189 | Kinesins | 0.380095 | 0.420 |
| R-HSA-351202 | Metabolism of polyamines | 0.380095 | 0.420 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.384448 | 0.415 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.384448 | 0.415 |
| R-HSA-112043 | PLC beta mediated events | 0.384448 | 0.415 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.384448 | 0.415 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.385619 | 0.414 |
| R-HSA-195721 | Signaling by WNT | 0.386335 | 0.413 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.388101 | 0.411 |
| R-HSA-9707616 | Heme signaling | 0.388771 | 0.410 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.388771 | 0.410 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.393064 | 0.406 |
| R-HSA-8848021 | Signaling by PTK6 | 0.393064 | 0.406 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.393064 | 0.406 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.395519 | 0.403 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.397327 | 0.401 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.397327 | 0.401 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.397327 | 0.401 |
| R-HSA-168256 | Immune System | 0.401552 | 0.396 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.401560 | 0.396 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.401560 | 0.396 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.405764 | 0.392 |
| R-HSA-112040 | G-protein mediated events | 0.409939 | 0.387 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.409939 | 0.387 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.409939 | 0.387 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.414084 | 0.383 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.414084 | 0.383 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.422289 | 0.374 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.422289 | 0.374 |
| R-HSA-448424 | Interleukin-17 signaling | 0.422289 | 0.374 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.422289 | 0.374 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.422289 | 0.374 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.422289 | 0.374 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.426348 | 0.370 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.426348 | 0.370 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.430380 | 0.366 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.430380 | 0.366 |
| R-HSA-5617833 | Cilium Assembly | 0.431972 | 0.365 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.433776 | 0.363 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.434362 | 0.362 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.434383 | 0.362 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.434383 | 0.362 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.436746 | 0.360 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.438358 | 0.358 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.441500 | 0.355 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.442306 | 0.354 |
| R-HSA-5689603 | UCH proteinases | 0.446226 | 0.350 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.450119 | 0.347 |
| R-HSA-5619084 | ABC transporter disorders | 0.453984 | 0.343 |
| R-HSA-4086400 | PCP/CE pathway | 0.453984 | 0.343 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.455627 | 0.341 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.460292 | 0.337 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.461635 | 0.336 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.462615 | 0.335 |
| R-HSA-72172 | mRNA Splicing | 0.467245 | 0.330 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.472912 | 0.325 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.472912 | 0.325 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.476619 | 0.322 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.476619 | 0.322 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.480300 | 0.318 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.480300 | 0.318 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.480300 | 0.318 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.483955 | 0.315 |
| R-HSA-397014 | Muscle contraction | 0.485529 | 0.314 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.485529 | 0.314 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.487585 | 0.312 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.491189 | 0.309 |
| R-HSA-9663891 | Selective autophagy | 0.494769 | 0.306 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.498323 | 0.302 |
| R-HSA-73884 | Base Excision Repair | 0.501853 | 0.299 |
| R-HSA-202424 | Downstream TCR signaling | 0.501853 | 0.299 |
| R-HSA-8951664 | Neddylation | 0.505633 | 0.296 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.512295 | 0.290 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.512295 | 0.290 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.512295 | 0.290 |
| R-HSA-2029481 | FCGR activation | 0.515727 | 0.288 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.515727 | 0.288 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.515727 | 0.288 |
| R-HSA-1474290 | Collagen formation | 0.519135 | 0.285 |
| R-HSA-597592 | Post-translational protein modification | 0.519157 | 0.285 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.525229 | 0.280 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.525880 | 0.279 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.528132 | 0.277 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.529218 | 0.276 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.529218 | 0.276 |
| R-HSA-1296071 | Potassium Channels | 0.529218 | 0.276 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.529218 | 0.276 |
| R-HSA-157579 | Telomere Maintenance | 0.532532 | 0.274 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.532532 | 0.274 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.533772 | 0.273 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.535823 | 0.271 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.540110 | 0.268 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.541352 | 0.267 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.542336 | 0.266 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.542336 | 0.266 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.545559 | 0.263 |
| R-HSA-5663205 | Infectious disease | 0.546527 | 0.262 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.548759 | 0.261 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.548759 | 0.261 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.555092 | 0.256 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.555092 | 0.256 |
| R-HSA-111885 | Opioid Signalling | 0.555092 | 0.256 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.561337 | 0.251 |
| R-HSA-4839726 | Chromatin organization | 0.564872 | 0.248 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.567496 | 0.246 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.570542 | 0.244 |
| R-HSA-202403 | TCR signaling | 0.576573 | 0.239 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.582519 | 0.235 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.585461 | 0.233 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.588382 | 0.230 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.591283 | 0.228 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.592548 | 0.227 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.594164 | 0.226 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.594164 | 0.226 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.597025 | 0.224 |
| R-HSA-373760 | L1CAM interactions | 0.599866 | 0.222 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.602686 | 0.220 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.604051 | 0.219 |
| R-HSA-5693538 | Homology Directed Repair | 0.605487 | 0.218 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.613370 | 0.212 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.613774 | 0.212 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.619202 | 0.208 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.619202 | 0.208 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.619202 | 0.208 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.621888 | 0.206 |
| R-HSA-1280218 | Adaptive Immune System | 0.627155 | 0.203 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.629833 | 0.201 |
| R-HSA-114608 | Platelet degranulation | 0.632444 | 0.199 |
| R-HSA-69481 | G2/M Checkpoints | 0.632444 | 0.199 |
| R-HSA-1266738 | Developmental Biology | 0.634677 | 0.197 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.640169 | 0.194 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.640455 | 0.194 |
| R-HSA-5576891 | Cardiac conduction | 0.645229 | 0.190 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.647733 | 0.189 |
| R-HSA-9909396 | Circadian clock | 0.647733 | 0.189 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.650219 | 0.187 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.652567 | 0.185 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.652581 | 0.185 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.659991 | 0.180 |
| R-HSA-5173105 | O-linked glycosylation | 0.662392 | 0.179 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.664775 | 0.177 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.664775 | 0.177 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.669493 | 0.174 |
| R-HSA-9664407 | Parasite infection | 0.669493 | 0.174 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.669493 | 0.174 |
| R-HSA-112316 | Neuronal System | 0.670494 | 0.174 |
| R-HSA-109582 | Hemostasis | 0.671543 | 0.173 |
| R-HSA-1632852 | Macroautophagy | 0.671826 | 0.173 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.689919 | 0.161 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.691717 | 0.160 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.696348 | 0.157 |
| R-HSA-8957322 | Metabolism of steroids | 0.697879 | 0.156 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.698591 | 0.156 |
| R-HSA-9609507 | Protein localization | 0.700721 | 0.154 |
| R-HSA-9612973 | Autophagy | 0.707022 | 0.151 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.709094 | 0.149 |
| R-HSA-9711097 | Cellular response to starvation | 0.711150 | 0.148 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.731374 | 0.136 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.736610 | 0.133 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.742162 | 0.130 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.742162 | 0.130 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.742162 | 0.130 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.743987 | 0.128 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.745799 | 0.127 |
| R-HSA-73894 | DNA Repair | 0.748891 | 0.126 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.754082 | 0.123 |
| R-HSA-3781865 | Diseases of glycosylation | 0.761544 | 0.118 |
| R-HSA-422475 | Axon guidance | 0.762963 | 0.117 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.768229 | 0.115 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.775412 | 0.110 |
| R-HSA-212436 | Generic Transcription Pathway | 0.785077 | 0.105 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.787187 | 0.104 |
| R-HSA-428157 | Sphingolipid metabolism | 0.788695 | 0.103 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.791681 | 0.101 |
| R-HSA-6805567 | Keratinization | 0.797527 | 0.098 |
| R-HSA-9675108 | Nervous system development | 0.799400 | 0.097 |
| R-HSA-388396 | GPCR downstream signalling | 0.814160 | 0.089 |
| R-HSA-72766 | Translation | 0.827296 | 0.082 |
| R-HSA-72312 | rRNA processing | 0.831758 | 0.080 |
| R-HSA-157118 | Signaling by NOTCH | 0.841086 | 0.075 |
| R-HSA-6798695 | Neutrophil degranulation | 0.852012 | 0.070 |
| R-HSA-5688426 | Deubiquitination | 0.857217 | 0.067 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.858463 | 0.066 |
| R-HSA-372790 | Signaling by GPCR | 0.869808 | 0.061 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.881425 | 0.055 |
| R-HSA-9658195 | Leishmania infection | 0.881425 | 0.055 |
| R-HSA-1474244 | Extracellular matrix organization | 0.917117 | 0.038 |
| R-HSA-1643685 | Disease | 0.917625 | 0.037 |
| R-HSA-392499 | Metabolism of proteins | 0.933468 | 0.030 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.941597 | 0.026 |
| R-HSA-418594 | G alpha (i) signalling events | 0.952358 | 0.021 |
| R-HSA-8978868 | Fatty acid metabolism | 0.952358 | 0.021 |
| R-HSA-5668914 | Diseases of metabolism | 0.958759 | 0.018 |
| R-HSA-168249 | Innate Immune System | 0.964916 | 0.016 |
| R-HSA-556833 | Metabolism of lipids | 0.984052 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 0.999297 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999947 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.779 | 0.197 | 1 | 0.780 |
KIS |
0.773 | 0.236 | 1 | 0.793 |
COT |
0.772 | 0.044 | 2 | 0.787 |
NLK |
0.771 | 0.324 | 1 | 0.783 |
SRPK1 |
0.767 | 0.138 | -3 | 0.688 |
TGFBR2 |
0.766 | 0.196 | -2 | 0.821 |
CDK8 |
0.766 | 0.248 | 1 | 0.765 |
CDK7 |
0.765 | 0.253 | 1 | 0.786 |
HIPK4 |
0.765 | 0.149 | 1 | 0.776 |
CDK19 |
0.763 | 0.244 | 1 | 0.751 |
ERK5 |
0.762 | 0.173 | 1 | 0.711 |
CDC7 |
0.762 | 0.033 | 1 | 0.686 |
CDK13 |
0.760 | 0.256 | 1 | 0.777 |
P38G |
0.760 | 0.290 | 1 | 0.715 |
NEK6 |
0.759 | 0.053 | -2 | 0.783 |
MOS |
0.759 | 0.030 | 1 | 0.717 |
GCN2 |
0.759 | 0.004 | 2 | 0.763 |
JNK2 |
0.758 | 0.294 | 1 | 0.758 |
PRPK |
0.758 | -0.002 | -1 | 0.505 |
BMPR1B |
0.758 | 0.198 | 1 | 0.580 |
DYRK2 |
0.758 | 0.223 | 1 | 0.793 |
NDR2 |
0.758 | -0.011 | -3 | 0.781 |
CDK5 |
0.757 | 0.253 | 1 | 0.784 |
CDK18 |
0.757 | 0.243 | 1 | 0.752 |
HIPK2 |
0.757 | 0.225 | 1 | 0.765 |
SRPK2 |
0.757 | 0.108 | -3 | 0.604 |
PIM3 |
0.757 | -0.005 | -3 | 0.774 |
JNK3 |
0.756 | 0.282 | 1 | 0.779 |
CDK12 |
0.756 | 0.255 | 1 | 0.763 |
DSTYK |
0.755 | 0.030 | 2 | 0.820 |
SMG1 |
0.755 | 0.293 | 1 | 0.679 |
ERK1 |
0.755 | 0.269 | 1 | 0.751 |
BMPR2 |
0.755 | 0.137 | -2 | 0.774 |
TBK1 |
0.754 | -0.017 | 1 | 0.534 |
CLK2 |
0.754 | 0.159 | -3 | 0.689 |
CLK1 |
0.753 | 0.156 | -3 | 0.657 |
ATM |
0.753 | 0.090 | 1 | 0.673 |
P38A |
0.753 | 0.267 | 1 | 0.770 |
CDKL5 |
0.753 | 0.057 | -3 | 0.707 |
ATR |
0.752 | 0.060 | 1 | 0.701 |
CDK1 |
0.752 | 0.242 | 1 | 0.756 |
CDK3 |
0.752 | 0.250 | 1 | 0.735 |
P38B |
0.752 | 0.272 | 1 | 0.749 |
PRKD1 |
0.752 | 0.008 | -3 | 0.763 |
P38D |
0.752 | 0.281 | 1 | 0.765 |
TGFBR1 |
0.752 | 0.215 | -2 | 0.853 |
CDKL1 |
0.752 | 0.041 | -3 | 0.714 |
LATS2 |
0.751 | 0.007 | -5 | 0.689 |
CDK9 |
0.751 | 0.241 | 1 | 0.780 |
SRPK3 |
0.751 | 0.105 | -3 | 0.648 |
CLK4 |
0.751 | 0.132 | -3 | 0.683 |
HIPK1 |
0.750 | 0.207 | 1 | 0.794 |
MTOR |
0.750 | -0.045 | 1 | 0.665 |
IKKE |
0.750 | -0.024 | 1 | 0.529 |
ALK4 |
0.750 | 0.230 | -2 | 0.846 |
NEK7 |
0.750 | -0.005 | -3 | 0.740 |
CDK17 |
0.750 | 0.240 | 1 | 0.721 |
RSK2 |
0.749 | 0.022 | -3 | 0.699 |
CHAK2 |
0.749 | 0.008 | -1 | 0.477 |
NUAK2 |
0.749 | 0.001 | -3 | 0.748 |
NDR1 |
0.748 | -0.026 | -3 | 0.757 |
ALK2 |
0.748 | 0.228 | -2 | 0.840 |
IKKB |
0.748 | -0.067 | -2 | 0.588 |
PRKD2 |
0.747 | 0.014 | -3 | 0.698 |
PKN3 |
0.747 | -0.014 | -3 | 0.734 |
ICK |
0.746 | 0.070 | -3 | 0.755 |
P90RSK |
0.746 | 0.008 | -3 | 0.709 |
CAMK1B |
0.746 | -0.052 | -3 | 0.761 |
MARK4 |
0.746 | -0.014 | 4 | 0.807 |
RSK3 |
0.746 | 0.007 | -3 | 0.697 |
ULK2 |
0.746 | -0.097 | 2 | 0.735 |
SKMLCK |
0.745 | -0.004 | -2 | 0.681 |
PDHK4 |
0.745 | -0.158 | 1 | 0.666 |
ERK2 |
0.745 | 0.253 | 1 | 0.762 |
PIM1 |
0.745 | 0.005 | -3 | 0.702 |
RAF1 |
0.744 | -0.147 | 1 | 0.627 |
PDHK1 |
0.744 | -0.118 | 1 | 0.648 |
BMPR1A |
0.744 | 0.192 | 1 | 0.573 |
DYRK4 |
0.744 | 0.220 | 1 | 0.773 |
ACVR2A |
0.744 | 0.143 | -2 | 0.799 |
ACVR2B |
0.743 | 0.151 | -2 | 0.799 |
DYRK1A |
0.743 | 0.171 | 1 | 0.797 |
TSSK1 |
0.743 | -0.004 | -3 | 0.792 |
AMPKA1 |
0.743 | -0.021 | -3 | 0.764 |
HUNK |
0.743 | -0.078 | 2 | 0.759 |
CAMLCK |
0.743 | 0.009 | -2 | 0.668 |
WNK1 |
0.743 | -0.030 | -2 | 0.700 |
NEK9 |
0.743 | 0.020 | 2 | 0.795 |
DYRK1B |
0.743 | 0.208 | 1 | 0.766 |
HIPK3 |
0.742 | 0.196 | 1 | 0.773 |
PRP4 |
0.742 | 0.204 | -3 | 0.788 |
AURC |
0.742 | 0.003 | -2 | 0.512 |
PKCD |
0.741 | -0.020 | 2 | 0.720 |
CAMK2G |
0.741 | -0.083 | 2 | 0.720 |
GRK1 |
0.741 | -0.004 | -2 | 0.624 |
MLK1 |
0.741 | -0.041 | 2 | 0.757 |
NIK |
0.741 | -0.062 | -3 | 0.785 |
CDK16 |
0.740 | 0.225 | 1 | 0.734 |
MAPKAPK3 |
0.740 | -0.010 | -3 | 0.701 |
DAPK2 |
0.740 | -0.003 | -3 | 0.774 |
P70S6KB |
0.739 | -0.012 | -3 | 0.704 |
LATS1 |
0.739 | 0.007 | -3 | 0.814 |
AMPKA2 |
0.739 | -0.010 | -3 | 0.734 |
DNAPK |
0.738 | 0.055 | 1 | 0.645 |
IKKA |
0.738 | -0.048 | -2 | 0.595 |
WNK3 |
0.738 | -0.083 | 1 | 0.602 |
PKACG |
0.738 | -0.033 | -2 | 0.589 |
FAM20C |
0.738 | 0.007 | 2 | 0.553 |
BCKDK |
0.738 | -0.123 | -1 | 0.436 |
TSSK2 |
0.738 | -0.031 | -5 | 0.696 |
MST4 |
0.738 | -0.059 | 2 | 0.769 |
DYRK3 |
0.737 | 0.157 | 1 | 0.788 |
NUAK1 |
0.737 | -0.037 | -3 | 0.697 |
CDK14 |
0.737 | 0.226 | 1 | 0.765 |
RIPK3 |
0.737 | -0.074 | 3 | 0.744 |
CDK4 |
0.737 | 0.264 | 1 | 0.762 |
CDK2 |
0.737 | 0.173 | 1 | 0.757 |
PHKG1 |
0.736 | -0.003 | -3 | 0.749 |
TTBK2 |
0.736 | -0.047 | 2 | 0.688 |
TLK2 |
0.736 | 0.054 | 1 | 0.597 |
MAPKAPK2 |
0.736 | -0.010 | -3 | 0.667 |
GRK5 |
0.736 | -0.104 | -3 | 0.758 |
IRE1 |
0.736 | -0.049 | 1 | 0.597 |
CAMK2D |
0.736 | -0.058 | -3 | 0.744 |
IRE2 |
0.735 | -0.030 | 2 | 0.683 |
PRKD3 |
0.735 | 0.002 | -3 | 0.665 |
MLK2 |
0.735 | -0.040 | 2 | 0.779 |
PLK1 |
0.735 | 0.002 | -2 | 0.757 |
NIM1 |
0.735 | -0.056 | 3 | 0.776 |
CDK10 |
0.735 | 0.215 | 1 | 0.765 |
GRK4 |
0.735 | -0.064 | -2 | 0.700 |
PKR |
0.734 | 0.025 | 1 | 0.644 |
PERK |
0.734 | 0.070 | -2 | 0.772 |
PKN2 |
0.734 | -0.057 | -3 | 0.739 |
ULK1 |
0.734 | -0.130 | -3 | 0.703 |
ERK7 |
0.734 | 0.146 | 2 | 0.561 |
PAK6 |
0.733 | 0.060 | -2 | 0.494 |
QSK |
0.733 | -0.016 | 4 | 0.785 |
MNK2 |
0.733 | -0.032 | -2 | 0.629 |
MELK |
0.733 | -0.024 | -3 | 0.715 |
CDK6 |
0.733 | 0.249 | 1 | 0.762 |
GRK6 |
0.733 | -0.054 | 1 | 0.611 |
MLK3 |
0.733 | -0.018 | 2 | 0.695 |
CAMK2B |
0.733 | -0.026 | 2 | 0.694 |
ANKRD3 |
0.733 | -0.078 | 1 | 0.638 |
MASTL |
0.732 | -0.128 | -2 | 0.660 |
AURB |
0.732 | -0.004 | -2 | 0.508 |
RSK4 |
0.732 | -0.007 | -3 | 0.680 |
GRK7 |
0.732 | 0.014 | 1 | 0.575 |
PKG2 |
0.732 | 0.011 | -2 | 0.531 |
JNK1 |
0.731 | 0.238 | 1 | 0.752 |
PKACB |
0.731 | -0.009 | -2 | 0.533 |
PAK3 |
0.730 | -0.044 | -2 | 0.569 |
PKCB |
0.730 | -0.028 | 2 | 0.697 |
CHAK1 |
0.730 | -0.032 | 2 | 0.754 |
VRK2 |
0.729 | 0.052 | 1 | 0.692 |
SGK3 |
0.729 | 0.001 | -3 | 0.677 |
SIK |
0.729 | -0.037 | -3 | 0.675 |
HRI |
0.728 | 0.014 | -2 | 0.761 |
PKCA |
0.728 | -0.023 | 2 | 0.679 |
PAK1 |
0.728 | -0.049 | -2 | 0.571 |
MLK4 |
0.728 | -0.035 | 2 | 0.688 |
NEK2 |
0.728 | -0.045 | 2 | 0.785 |
PLK3 |
0.728 | -0.017 | 2 | 0.690 |
DCAMKL1 |
0.728 | 0.004 | -3 | 0.719 |
MAK |
0.728 | 0.146 | -2 | 0.532 |
BRSK1 |
0.727 | -0.032 | -3 | 0.712 |
PKCZ |
0.727 | -0.052 | 2 | 0.744 |
RIPK1 |
0.727 | -0.142 | 1 | 0.605 |
PRKX |
0.727 | -0.005 | -3 | 0.621 |
QIK |
0.726 | -0.072 | -3 | 0.730 |
MSK2 |
0.726 | -0.057 | -3 | 0.672 |
PIM2 |
0.726 | 0.009 | -3 | 0.653 |
PINK1 |
0.726 | 0.020 | 1 | 0.716 |
MARK2 |
0.726 | -0.023 | 4 | 0.740 |
CAMK4 |
0.726 | -0.097 | -3 | 0.717 |
TLK1 |
0.725 | 0.015 | -2 | 0.784 |
BRSK2 |
0.725 | -0.045 | -3 | 0.721 |
MNK1 |
0.725 | -0.056 | -2 | 0.636 |
PLK4 |
0.725 | -0.045 | 2 | 0.575 |
MOK |
0.724 | 0.145 | 1 | 0.763 |
CHK1 |
0.724 | -0.049 | -3 | 0.750 |
AURA |
0.724 | -0.022 | -2 | 0.487 |
MEK1 |
0.724 | -0.052 | 2 | 0.777 |
CAMK2A |
0.724 | -0.058 | 2 | 0.711 |
DLK |
0.724 | -0.179 | 1 | 0.592 |
PKCG |
0.724 | -0.065 | 2 | 0.681 |
YSK4 |
0.723 | -0.062 | 1 | 0.554 |
NEK5 |
0.723 | 0.037 | 1 | 0.613 |
MYLK4 |
0.723 | -0.014 | -2 | 0.586 |
MSK1 |
0.723 | -0.027 | -3 | 0.673 |
AKT2 |
0.723 | -0.007 | -3 | 0.608 |
MARK3 |
0.722 | -0.039 | 4 | 0.758 |
MEKK1 |
0.722 | -0.042 | 1 | 0.592 |
PKCH |
0.721 | -0.060 | 2 | 0.678 |
PKACA |
0.721 | -0.007 | -2 | 0.492 |
IRAK4 |
0.721 | -0.042 | 1 | 0.598 |
PAK2 |
0.719 | -0.063 | -2 | 0.557 |
WNK4 |
0.719 | -0.050 | -2 | 0.696 |
MAPKAPK5 |
0.718 | -0.062 | -3 | 0.627 |
SSTK |
0.717 | -0.038 | 4 | 0.770 |
MEKK2 |
0.717 | -0.042 | 2 | 0.760 |
AKT1 |
0.716 | -0.008 | -3 | 0.629 |
PKCT |
0.716 | -0.052 | 2 | 0.685 |
GRK2 |
0.715 | -0.067 | -2 | 0.613 |
PAK5 |
0.715 | 0.001 | -2 | 0.440 |
PAK4 |
0.715 | 0.017 | -2 | 0.456 |
DCAMKL2 |
0.715 | -0.031 | -3 | 0.727 |
DRAK1 |
0.715 | -0.074 | 1 | 0.547 |
PHKG2 |
0.715 | -0.051 | -3 | 0.698 |
MARK1 |
0.714 | -0.071 | 4 | 0.773 |
MPSK1 |
0.714 | -0.013 | 1 | 0.617 |
SNRK |
0.714 | -0.119 | 2 | 0.617 |
P70S6K |
0.713 | -0.027 | -3 | 0.609 |
MEK5 |
0.713 | -0.126 | 2 | 0.769 |
CAMK1G |
0.713 | -0.078 | -3 | 0.658 |
GSK3A |
0.712 | 0.021 | 4 | 0.357 |
CK2A2 |
0.712 | 0.019 | 1 | 0.566 |
TAO3 |
0.712 | -0.056 | 1 | 0.589 |
ZAK |
0.711 | -0.123 | 1 | 0.548 |
BRAF |
0.710 | -0.137 | -4 | 0.776 |
SMMLCK |
0.709 | -0.051 | -3 | 0.713 |
MST3 |
0.709 | -0.041 | 2 | 0.781 |
CAMK1D |
0.709 | -0.043 | -3 | 0.600 |
TTBK1 |
0.709 | -0.064 | 2 | 0.591 |
TAO2 |
0.709 | -0.020 | 2 | 0.781 |
DAPK3 |
0.708 | -0.018 | -3 | 0.723 |
BUB1 |
0.707 | 0.052 | -5 | 0.661 |
NEK8 |
0.707 | -0.071 | 2 | 0.760 |
MEKK3 |
0.706 | -0.162 | 1 | 0.572 |
PKCI |
0.706 | -0.063 | 2 | 0.706 |
AKT3 |
0.706 | -0.008 | -3 | 0.563 |
PDK1 |
0.705 | -0.040 | 1 | 0.626 |
PKN1 |
0.705 | -0.024 | -3 | 0.627 |
SGK1 |
0.705 | 0.001 | -3 | 0.540 |
LKB1 |
0.705 | -0.066 | -3 | 0.757 |
CHK2 |
0.705 | -0.003 | -3 | 0.556 |
MRCKB |
0.705 | 0.014 | -3 | 0.642 |
TNIK |
0.705 | 0.002 | 3 | 0.849 |
GRK3 |
0.704 | -0.059 | -2 | 0.588 |
GSK3B |
0.704 | -0.029 | 4 | 0.347 |
CK1E |
0.704 | -0.076 | -3 | 0.488 |
GAK |
0.703 | -0.047 | 1 | 0.643 |
PLK2 |
0.703 | -0.017 | -3 | 0.741 |
ROCK2 |
0.703 | 0.004 | -3 | 0.707 |
NEK4 |
0.703 | -0.064 | 1 | 0.579 |
CAMKK1 |
0.703 | -0.095 | -2 | 0.602 |
TTK |
0.702 | 0.073 | -2 | 0.785 |
EEF2K |
0.702 | 0.007 | 3 | 0.827 |
VRK1 |
0.702 | 0.035 | 2 | 0.755 |
PKCE |
0.702 | -0.038 | 2 | 0.673 |
HGK |
0.702 | -0.026 | 3 | 0.851 |
CK1G1 |
0.702 | -0.072 | -3 | 0.501 |
IRAK1 |
0.701 | -0.174 | -1 | 0.438 |
PASK |
0.701 | -0.100 | -3 | 0.786 |
PKG1 |
0.701 | -0.008 | -2 | 0.466 |
NEK1 |
0.700 | -0.022 | 1 | 0.582 |
CAMK1A |
0.699 | -0.033 | -3 | 0.575 |
LOK |
0.699 | -0.028 | -2 | 0.603 |
MST2 |
0.699 | -0.078 | 1 | 0.578 |
LRRK2 |
0.699 | -0.068 | 2 | 0.790 |
CK2A1 |
0.699 | 0.001 | 1 | 0.543 |
SBK |
0.699 | 0.005 | -3 | 0.496 |
CAMKK2 |
0.698 | -0.114 | -2 | 0.594 |
CK1D |
0.697 | -0.062 | -3 | 0.435 |
MRCKA |
0.697 | -0.014 | -3 | 0.662 |
MINK |
0.697 | -0.057 | 1 | 0.564 |
GCK |
0.696 | -0.076 | 1 | 0.569 |
DAPK1 |
0.696 | -0.039 | -3 | 0.700 |
MAP3K15 |
0.696 | -0.104 | 1 | 0.549 |
MEKK6 |
0.695 | -0.108 | 1 | 0.550 |
MEK2 |
0.694 | -0.046 | 2 | 0.766 |
KHS1 |
0.694 | -0.024 | 1 | 0.574 |
NEK11 |
0.694 | -0.169 | 1 | 0.582 |
TAK1 |
0.694 | -0.034 | 1 | 0.596 |
KHS2 |
0.693 | -0.009 | 1 | 0.582 |
NEK3 |
0.693 | -0.061 | 1 | 0.556 |
HPK1 |
0.693 | -0.049 | 1 | 0.569 |
SLK |
0.692 | -0.079 | -2 | 0.559 |
PBK |
0.691 | -0.041 | 1 | 0.582 |
YSK1 |
0.690 | -0.058 | 2 | 0.770 |
PDHK3_TYR |
0.690 | 0.114 | 4 | 0.813 |
OSR1 |
0.690 | -0.011 | 2 | 0.753 |
ROCK1 |
0.690 | -0.007 | -3 | 0.662 |
BIKE |
0.690 | 0.024 | 1 | 0.564 |
DMPK1 |
0.689 | -0.017 | -3 | 0.666 |
CK1A2 |
0.689 | -0.082 | -3 | 0.432 |
HASPIN |
0.687 | -0.054 | -1 | 0.369 |
MST1 |
0.687 | -0.119 | 1 | 0.562 |
CRIK |
0.686 | -0.004 | -3 | 0.622 |
STK33 |
0.685 | -0.128 | 2 | 0.558 |
TXK |
0.685 | 0.202 | 1 | 0.588 |
RIPK2 |
0.685 | -0.150 | 1 | 0.535 |
MYO3B |
0.684 | -0.011 | 2 | 0.779 |
TAO1 |
0.684 | -0.030 | 1 | 0.529 |
AAK1 |
0.681 | 0.046 | 1 | 0.498 |
MAP2K4_TYR |
0.680 | 0.009 | -1 | 0.507 |
ABL2 |
0.679 | 0.089 | -1 | 0.525 |
LIMK2_TYR |
0.679 | 0.031 | -3 | 0.799 |
TESK1_TYR |
0.678 | -0.064 | 3 | 0.859 |
PDHK4_TYR |
0.678 | -0.026 | 2 | 0.783 |
BLK |
0.678 | 0.131 | -1 | 0.531 |
TYRO3 |
0.677 | 0.124 | 3 | 0.806 |
PKMYT1_TYR |
0.677 | -0.050 | 3 | 0.833 |
MAP2K7_TYR |
0.676 | -0.073 | 2 | 0.781 |
MAP2K6_TYR |
0.676 | -0.049 | -1 | 0.489 |
RET |
0.676 | 0.002 | 1 | 0.598 |
EPHB4 |
0.676 | 0.075 | -1 | 0.531 |
LCK |
0.675 | 0.108 | -1 | 0.530 |
YES1 |
0.675 | 0.092 | -1 | 0.552 |
TEC |
0.675 | 0.181 | -1 | 0.567 |
TNK2 |
0.675 | 0.112 | 3 | 0.783 |
ASK1 |
0.674 | -0.102 | 1 | 0.548 |
EPHA6 |
0.673 | 0.007 | -1 | 0.505 |
CSF1R |
0.673 | 0.027 | 3 | 0.796 |
MYO3A |
0.673 | -0.076 | 1 | 0.581 |
ROS1 |
0.672 | 0.034 | 3 | 0.785 |
MERTK |
0.672 | 0.171 | 3 | 0.768 |
ABL1 |
0.671 | 0.053 | -1 | 0.526 |
HCK |
0.671 | 0.103 | -1 | 0.545 |
PINK1_TYR |
0.671 | -0.133 | 1 | 0.647 |
TYK2 |
0.670 | -0.042 | 1 | 0.593 |
ALPHAK3 |
0.670 | -0.114 | -1 | 0.436 |
BMX |
0.670 | 0.102 | -1 | 0.534 |
MST1R |
0.670 | -0.021 | 3 | 0.805 |
ITK |
0.670 | 0.098 | -1 | 0.533 |
LIMK1_TYR |
0.669 | -0.092 | 2 | 0.788 |
SRMS |
0.669 | 0.093 | 1 | 0.606 |
PDHK1_TYR |
0.669 | -0.112 | -1 | 0.496 |
FER |
0.669 | 0.021 | 1 | 0.637 |
BMPR2_TYR |
0.669 | -0.105 | -1 | 0.465 |
BTK |
0.668 | 0.158 | -1 | 0.570 |
JAK2 |
0.668 | -0.030 | 1 | 0.593 |
STLK3 |
0.668 | -0.080 | 1 | 0.525 |
FGR |
0.667 | -0.030 | 1 | 0.587 |
AXL |
0.666 | 0.089 | 3 | 0.776 |
JAK1 |
0.666 | 0.020 | 1 | 0.544 |
EPHB3 |
0.665 | 0.055 | -1 | 0.532 |
JAK3 |
0.664 | -0.093 | 1 | 0.581 |
EPHB2 |
0.664 | 0.048 | -1 | 0.521 |
TEK |
0.664 | 0.062 | 3 | 0.745 |
EPHB1 |
0.664 | 0.046 | 1 | 0.598 |
NEK10_TYR |
0.663 | -0.026 | 1 | 0.516 |
FYN |
0.663 | 0.043 | -1 | 0.497 |
DDR1 |
0.662 | -0.095 | 4 | 0.742 |
FRK |
0.662 | 0.102 | -1 | 0.577 |
FGFR2 |
0.662 | -0.044 | 3 | 0.777 |
YANK3 |
0.662 | -0.088 | 2 | 0.347 |
TNNI3K_TYR |
0.662 | -0.045 | 1 | 0.603 |
TNK1 |
0.661 | -0.048 | 3 | 0.779 |
KIT |
0.661 | -0.048 | 3 | 0.791 |
EPHA4 |
0.661 | -0.014 | 2 | 0.674 |
INSRR |
0.661 | -0.069 | 3 | 0.754 |
EPHA1 |
0.660 | 0.086 | 3 | 0.766 |
ALK |
0.659 | 0.009 | 3 | 0.740 |
LTK |
0.659 | 0.029 | 3 | 0.748 |
FLT3 |
0.658 | -0.056 | 3 | 0.801 |
LYN |
0.658 | 0.054 | 3 | 0.725 |
FGFR1 |
0.658 | -0.059 | 3 | 0.774 |
KDR |
0.657 | -0.072 | 3 | 0.758 |
WEE1_TYR |
0.657 | -0.018 | -1 | 0.472 |
PDGFRB |
0.657 | -0.097 | 3 | 0.808 |
PTK6 |
0.657 | -0.025 | -1 | 0.488 |
MET |
0.657 | -0.056 | 3 | 0.785 |
EPHA7 |
0.655 | 0.020 | 2 | 0.689 |
PTK2B |
0.655 | 0.043 | -1 | 0.548 |
CK1A |
0.652 | -0.105 | -3 | 0.361 |
DDR2 |
0.650 | -0.033 | 3 | 0.753 |
FGFR3 |
0.650 | -0.068 | 3 | 0.754 |
PDGFRA |
0.650 | -0.111 | 3 | 0.804 |
SRC |
0.650 | 0.001 | -1 | 0.510 |
MATK |
0.649 | -0.066 | -1 | 0.444 |
NTRK1 |
0.649 | -0.101 | -1 | 0.485 |
EPHA5 |
0.648 | -0.004 | 2 | 0.662 |
NTRK3 |
0.647 | -0.059 | -1 | 0.469 |
EPHA3 |
0.647 | -0.062 | 2 | 0.654 |
EPHA8 |
0.647 | -0.026 | -1 | 0.487 |
NTRK2 |
0.645 | -0.094 | 3 | 0.747 |
ERBB2 |
0.644 | -0.102 | 1 | 0.541 |
INSR |
0.644 | -0.103 | 3 | 0.740 |
EGFR |
0.642 | -0.059 | 1 | 0.456 |
FLT1 |
0.642 | -0.147 | -1 | 0.439 |
CK1G3 |
0.642 | -0.077 | -3 | 0.320 |
FGFR4 |
0.640 | -0.061 | -1 | 0.460 |
FLT4 |
0.640 | -0.154 | 3 | 0.742 |
CSK |
0.639 | -0.091 | 2 | 0.689 |
MUSK |
0.637 | -0.057 | 1 | 0.444 |
EPHA2 |
0.635 | -0.037 | -1 | 0.474 |
SYK |
0.634 | -0.076 | -1 | 0.416 |
IGF1R |
0.631 | -0.097 | 3 | 0.672 |
PTK2 |
0.631 | -0.089 | -1 | 0.401 |
FES |
0.629 | -0.031 | -1 | 0.490 |
ERBB4 |
0.628 | -0.068 | 1 | 0.477 |
YANK2 |
0.627 | -0.107 | 2 | 0.361 |
ZAP70 |
0.622 | -0.064 | -1 | 0.379 |
CK1G2 |
0.622 | -0.090 | -3 | 0.413 |