Motif 799 (n=207)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NMY6 | ANXA2P2 | S164 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| O14513 | NCKAP5 | S613 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14737 | PDCD5 | S51 | ochoa | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | May function in the process of apoptosis. |
| O15014 | ZNF609 | S777 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O43159 | RRP8 | S126 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O43290 | SART1 | S111 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43313 | ATMIN | S393 | ochoa | ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822) | Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732, ECO:0000269|PubMed:22167198}. |
| O60662 | KLHL41 | S244 | ochoa | Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9}. |
| O60741 | HCN1 | S599 | psp | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}. |
| O60934 | NBN | S411 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75113 | N4BP1 | S398 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O75128 | COBL | S235 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75362 | ZNF217 | S445 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75534 | CSDE1 | S276 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O75563 | SKAP2 | S203 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O94782 | USP1 | S273 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94913 | PCF11 | S120 | psp | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95163 | ELP1 | S867 | ochoa | Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). {ECO:0000250|UniProtKB:Q06706, ECO:0000250|UniProtKB:Q7TT37, ECO:0000269|PubMed:9751059, ECO:0000303|PubMed:29332244}. |
| O95801 | TTC4 | S51 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| O95997 | PTTG1 | S87 | psp | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}. |
| P01111 | NRAS | S89 | psp | GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000269|PubMed:30712867}. |
| P02042 | HBD | S50 | ochoa | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | Involved in oxygen transport from the lung to the various peripheral tissues. |
| P02545 | LMNA | S458 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P04083 | ANXA1 | S173 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P05107 | ITGB2 | S350 | ochoa | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}. |
| P07355 | ANXA2 | S164 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P10451 | SPP1 | S280 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11142 | HSPA8 | S538 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11940 | PABPC1 | S92 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P13521 | SCG2 | S285 | ochoa | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
| P13521 | SCG2 | S395 | ochoa | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
| P14618 | PKM | S249 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P15531 | NME1 | S44 | psp | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P15884 | TCF4 | S546 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P18858 | LIG1 | S47 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P18858 | LIG1 | S229 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P20929 | NEB | S2358 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P22234 | PAICS | S35 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P22392 | NME2 | S44 | ochoa|psp | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P24539 | ATP5PB | S226 | ochoa | ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P33241 | LSP1 | S282 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P34932 | HSPA4 | S692 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P35241 | RDX | S532 | ochoa | Radixin | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| P35348 | ADRA1A | S402 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35367 | HRH1 | S363 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P35610 | SOAT1 | S33 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P37173 | TGFBR2 | S486 | ochoa | TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. {ECO:0000269|PubMed:7774578}.; FUNCTION: [Isoform 1]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 2]: Has transforming growth factor beta-activated receptor activity. {ECO:0000269|PubMed:8635485}.; FUNCTION: [Isoform 3]: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1. {ECO:0000269|PubMed:34568316}. |
| P38117 | ETFB | S226 | ochoa | Electron transfer flavoprotein subunit beta (Beta-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:15159392, PubMed:15975918, PubMed:25416781). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:15159392, PubMed:15975918, PubMed:8962055). {ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:25416781, ECO:0000269|PubMed:7912128, ECO:0000269|PubMed:8962055, ECO:0000303|PubMed:17941859, ECO:0000305}. |
| P38398 | BRCA1 | S1266 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38919 | EIF4A3 | S62 | ochoa | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16170325, PubMed:16209946, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15034551, ECO:0000269|PubMed:16170325, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:16923391, ECO:0000269|PubMed:16931718, ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:19033377, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:20479275, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:24360810, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| P42224 | STAT1 | S640 | ochoa | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:P42225, ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:23940278, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35568036, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754, ECO:0000303|PubMed:15526160}. |
| P43246 | MSH2 | S479 | ochoa | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:26300262, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P46013 | MKI67 | S1740 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S84 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46736 | BRCC3 | S258 | ochoa | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (PubMed:14636569, PubMed:16707425, PubMed:17525341, PubMed:19202061, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26195665, PubMed:26344097). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity). {ECO:0000250|UniProtKB:P46737, ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26344097}. |
| P47712 | PLA2G4A | S729 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P51531 | SMARCA2 | S670 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51532 | SMARCA4 | S699 | ochoa|psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51587 | BRCA2 | S805 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52701 | MSH6 | S137 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P54132 | BLM | S26 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54198 | HIRA | S610 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P55010 | EIF5 | S410 | ochoa | Eukaryotic translation initiation factor 5 (eIF-5) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}. |
| P55210 | CASP7 | S29 | ochoa | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:15314233, PubMed:17697120, PubMed:19581639, PubMed:20566630, PubMed:23650375, PubMed:23897474, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:27889207, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}. |
| P60842 | EIF4A1 | S56 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P62280 | RPS11 | S67 | ochoa | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P63244 | RACK1 | S160 | ochoa | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
| P68871 | HBB | S50 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| P82094 | TMF1 | S199 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01432 | AMPD3 | S85 | ochoa | AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) | AMP deaminase plays a critical role in energy metabolism. {ECO:0000305|PubMed:9291127}. |
| Q01970 | PLCB3 | S1105 | ochoa|psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q02952 | AKAP12 | S514 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q08945 | SSRP1 | S578 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q13310 | PABPC4 | S92 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13501 | SQSTM1 | S332 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q14005 | IL16 | S966 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14204 | DYNC1H1 | S1230 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14240 | EIF4A2 | S57 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14517 | FAT1 | S4285 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14789 | GOLGB1 | S653 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14CB8 | ARHGAP19 | S386 | ochoa | Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q15424 | SAFB | S576 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q16821 | PPP1R3A | S290 | ochoa | Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}. |
| Q3KR37 | GRAMD1B | S540 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q5JQF8 | PABPC1L2A | S83 | ochoa | Polyadenylate-binding protein 1-like 2 (RNA-binding motif protein 32) (RNA-binding protein 32) | None |
| Q5JTH9 | RRP12 | S97 | ochoa | RRP12-like protein | None |
| Q5SYC1 | CLVS2 | S302 | ochoa | Clavesin-2 (Retinaldehyde-binding protein 1-like 2) (clathrin vesicle-associated Sec14 protein 2) | Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}. |
| Q5T0W9 | FAM83B | S542 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5VUB5 | FAM171A1 | S564 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VV52 | ZNF691 | S75 | ochoa | Zinc finger protein 691 | May be involved in transcriptional regulation. |
| Q5W0B1 | OBI1 | S443 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q674X7 | KAZN | S387 | ochoa | Kazrin | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
| Q68D51 | DENND2C | S507 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6NZY4 | ZCCHC8 | S597 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6P4F7 | ARHGAP11A | S937 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PCB8 | EMB | S309 | ochoa | Embigin | Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O88775}. |
| Q6PL18 | ATAD2 | S1302 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UB98 | ANKRD12 | S630 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UX04 | CWC27 | S266 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q6UXM1 | LRIG3 | S984 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) | May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}. |
| Q6W2J9 | BCOR | S771 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6WKZ4 | RAB11FIP1 | S156 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6WKZ4 | RAB11FIP1 | S477 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZMU5 | TRIM72 | S305 | ochoa | Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) | Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:Q1XH17, ECO:0000269|PubMed:36944613}. |
| Q6ZRV2 | FAM83H | S436 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZV73 | FGD6 | S552 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7L576 | CYFIP1 | S582 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7Z2W4 | ZC3HAV1 | S284 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3T8 | ZFYVE16 | S193 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z417 | NUFIP2 | S250 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z5J4 | RAI1 | S1394 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z7A4 | PXK | S448 | ochoa | PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA) | Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. {ECO:0000250|UniProtKB:Q8BX57, ECO:0000303|PubMed:16142408}. |
| Q86T65 | DAAM2 | S656 | ochoa | Disheveled-associated activator of morphogenesis 2 | Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (PubMed:33232676). {ECO:0000250|UniProtKB:Q80U19, ECO:0000269|PubMed:33232676}. |
| Q86U70 | LDB1 | S265 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q86UP2 | KTN1 | S1185 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86UW2 | SLC51B | S88 | ochoa | Organic solute transporter subunit beta (OST-beta) (Solute carrier family 51 subunit beta) | Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684). Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:16317684). The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q8R000, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:16317684}. |
| Q86XA9 | HEATR5A | S62 | ochoa | HEAT repeat-containing protein 5A | None |
| Q8IX01 | SUGP2 | S93 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IYL3 | C1orf174 | S46 | ochoa | UPF0688 protein C1orf174 | None |
| Q8IZD4 | DCP1B | S186 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8N4C8 | MINK1 | S478 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N554 | ZNF276 | S360 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
| Q8N554 | ZNF276 | S382 | ochoa | Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) | May be involved in transcriptional regulation. |
| Q8N565 | MREG | S38 | ochoa | Melanoregulin (Dilute suppressor protein homolog) | Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). {ECO:0000250|UniProtKB:Q6NVG5, ECO:0000269|PubMed:19240024}. |
| Q8NI27 | THOC2 | S1486 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TD26 | CHD6 | S1673 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TDM6 | DLG5 | S1795 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDY2 | RB1CC1 | S1221 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8WUF8 | ARB2A | S220 | ochoa | Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A) | Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}. |
| Q8WVM8 | SCFD1 | S316 | ochoa|psp | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WVM8 | SCFD1 | S384 | ochoa | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WXD5 | GEMIN6 | S95 | ochoa | Gem-associated protein 6 (Gemin-6) (SIP2) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}. |
| Q92878 | RAD50 | S471 | ochoa | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q969I6 | SLC38A4 | S49 | ochoa | Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}. |
| Q96AT1 | KIAA1143 | S68 | ochoa | Uncharacterized protein KIAA1143 | None |
| Q96CM3 | RPUSD4 | S221 | ochoa | Pseudouridylate synthase RPUSD4, mitochondrial (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4) | Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates (PubMed:27974379, PubMed:28082677). Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) (PubMed:27974379). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677, ECO:0000269|PubMed:35051350}. |
| Q96DT7 | ZBTB10 | S565 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96GQ7 | DDX27 | S746 | ochoa | Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) | Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154). {ECO:0000269|PubMed:25825154}. |
| Q96KR1 | ZFR | S590 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96QT4 | TRPM7 | S1446 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T58 | SPEN | S1333 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99549 | MPHOSPH8 | S51 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99729 | HNRNPAB | S81 | ochoa | Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1) | Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. |
| Q9BXW9 | FANCD2 | S178 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BXW9 | FANCD2 | S1412 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BYJ9 | YTHDF1 | S398 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
| Q9GZU2 | PEG3 | S671 | ochoa | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}. |
| Q9H0C3 | TMEM117 | S456 | ochoa | Transmembrane protein 117 | Involved in endoplasmic reticulum (ER) stress-induced cell death pathway. {ECO:0000269|PubMed:28285135}. |
| Q9H0H5 | RACGAP1 | S206 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H0H5 | RACGAP1 | S387 | psp | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H361 | PABPC3 | S92 | ochoa | Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. |
| Q9HAW4 | CLSPN | S954 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HD26 | GOPC | S412 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NR09 | BIRC6 | S486 | ochoa|psp | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NR09 | BIRC6 | S2221 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NR80 | ARHGEF4 | S65 | ochoa | Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}. |
| Q9NRW7 | VPS45 | S307 | ochoa | Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45) | May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. |
| Q9NUW8 | TDP1 | S365 | psp | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}. |
| Q9NV56 | MRGBP | S147 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Q9NVU7 | SDAD1 | S595 | ochoa | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}. |
| Q9NYL2 | MAP3K20 | S268 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P2W9 | STX18 | S194 | ochoa | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}. |
| Q9UBT2 | UBA2 | S229 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
| Q9UJU6 | DBNL | S160 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q9UKI8 | TLK1 | S133 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UMZ2 | SYNRG | S494 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UNE7 | STUB1 | S191 | ochoa | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}. |
| Q9UNL2 | SSR3 | S105 | ochoa | Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. |
| Q9UNY4 | TTF2 | S271 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPT8 | ZC3H4 | S172 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UPV0 | CEP164 | S359 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQC2 | GAB2 | S425 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y210 | TRPC6 | S815 | ochoa|psp | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y383 | LUC7L2 | S353 | ochoa | Putative RNA-binding protein Luc7-like 2 | May bind to RNA via its Arg/Ser-rich domain. |
| Q9Y462 | ZNF711 | S462 | ochoa | Zinc finger protein 711 (Zinc finger protein 6) | Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}. |
| Q9Y485 | DMXL1 | S1379 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4B5 | MTCL1 | S794 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y572 | RIPK3 | S339 | ochoa | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y5X3 | SNX5 | S226 | psp | Sorting nexin-5 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}. |
| P25208 | NFYB | S99 | Sugiyama | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| P30740 | SERPINB1 | S118 | Sugiyama | Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). {ECO:0000269|PubMed:11747453, ECO:0000269|PubMed:23269243, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}. |
| P17174 | GOT1 | S85 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| O60285 | NUAK1 | S313 | Sugiyama | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| Q8TDD1 | DDX54 | S581 | Sugiyama | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| O94806 | PRKD3 | S376 | Sugiyama | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| P49321 | NASP | S659 | Sugiyama | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P23142 | FBLN1 | Y175 | Sugiyama | Fibulin-1 (FIBL-1) | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. |
| P07942 | LAMB1 | S448 | Sugiyama | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P61201 | COPS2 | S178 | Sugiyama | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| P27540 | ARNT | S558 | Sugiyama | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}. |
| Q9Y5K3 | PCYT1B | S174 | Sugiyama | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| P52907 | CAPZA1 | S244 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| Q99961 | SH3GL1 | S64 | Sugiyama | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
| Q99962 | SH3GL2 | S64 | Sugiyama | Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}. |
| Q08881 | ITK | S284 | Sugiyama | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| P25815 | S100P | S47 | Sugiyama | Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P) | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}. |
| P07711 | CTSL | S301 | Sugiyama | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] | Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). {ECO:0000250|UniProtKB:P06797, ECO:0000250|UniProtKB:P07154, ECO:0000250|UniProtKB:P25975, ECO:0000269|PubMed:10716919, ECO:0000305}.; FUNCTION: (Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell (PubMed:16339146, PubMed:18562523, PubMed:32142651, PubMed:32221306, PubMed:37990007). Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins (PubMed:16081529, PubMed:18562523, PubMed:26953343). {ECO:0000269|PubMed:16081529, ECO:0000269|PubMed:16339146, ECO:0000269|PubMed:18562523, ECO:0000269|PubMed:26953343, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:37990007}.; FUNCTION: [Isoform 2]: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor (PubMed:15099520). Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties (PubMed:15099520). {ECO:0000269|PubMed:15099520}. |
| Q96GQ7 | DDX27 | S98 | Sugiyama | Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) | Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154). {ECO:0000269|PubMed:25825154}. |
| Q9UL51 | HCN2 | S668 | SIGNOR | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| P47755 | CAPZA2 | S244 | Sugiyama | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
| P47712 | PLA2G4A | S458 | Sugiyama | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| Q15154 | PCM1 | S1229 | Sugiyama | Pericentriolar material 1 protein (PCM-1) (hPCM-1) | Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:34782749}. |
| Q9Y4E8 | USP15 | S170 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) | Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178, ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}. |
| P41252 | IARS1 | S827 | Sugiyama | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| P48643 | CCT5 | S235 | Sugiyama | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9NRM7 | LATS2 | S653 | Sugiyama | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9P0L2 | MARK1 | S711 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.000031 | 4.508 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.000038 | 4.425 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.000038 | 4.425 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.000038 | 4.425 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.000038 | 4.425 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.000023 | 4.631 |
| R-HSA-9675135 | Diseases of DNA repair | 0.000017 | 4.767 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000006 | 5.224 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.000099 | 4.005 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.000103 | 3.988 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.000180 | 3.745 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.000413 | 3.385 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.000370 | 3.432 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.000370 | 3.432 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.000412 | 3.385 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.000331 | 3.481 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.000295 | 3.531 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.000562 | 3.250 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.000810 | 3.092 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.000919 | 3.037 |
| R-HSA-429947 | Deadenylation of mRNA | 0.001043 | 2.982 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.001475 | 2.831 |
| R-HSA-73894 | DNA Repair | 0.001505 | 2.822 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.002068 | 2.684 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.002068 | 2.684 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.002429 | 2.615 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.002091 | 2.680 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.002685 | 2.571 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.002505 | 2.601 |
| R-HSA-1500620 | Meiosis | 0.002595 | 2.586 |
| R-HSA-912446 | Meiotic recombination | 0.001849 | 2.733 |
| R-HSA-177929 | Signaling by EGFR | 0.002621 | 2.582 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.002455 | 2.610 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.002413 | 2.617 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.002693 | 2.570 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.002880 | 2.541 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.003182 | 2.497 |
| R-HSA-5693538 | Homology Directed Repair | 0.003459 | 2.461 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.003483 | 2.458 |
| R-HSA-1296061 | HCN channels | 0.003573 | 2.447 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.003869 | 2.412 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.004250 | 2.372 |
| R-HSA-5358508 | Mismatch Repair | 0.004806 | 2.318 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.005099 | 2.293 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.005329 | 2.273 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.005171 | 2.286 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.004898 | 2.310 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.005587 | 2.253 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.005683 | 2.245 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.006042 | 2.219 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.006042 | 2.219 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.006645 | 2.177 |
| R-HSA-449147 | Signaling by Interleukins | 0.006787 | 2.168 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.006885 | 2.162 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.006885 | 2.162 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.007347 | 2.134 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.008027 | 2.095 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.008224 | 2.085 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.008224 | 2.085 |
| R-HSA-75153 | Apoptotic execution phase | 0.008369 | 2.077 |
| R-HSA-199991 | Membrane Trafficking | 0.009513 | 2.022 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.009556 | 2.020 |
| R-HSA-6806834 | Signaling by MET | 0.009759 | 2.011 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.010814 | 1.966 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.010814 | 1.966 |
| R-HSA-390696 | Adrenoceptors | 0.011453 | 1.941 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.011511 | 1.939 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.012607 | 1.899 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.011770 | 1.929 |
| R-HSA-3295583 | TRP channels | 0.011770 | 1.929 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.012793 | 1.893 |
| R-HSA-72649 | Translation initiation complex formation | 0.013306 | 1.876 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.013502 | 1.870 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.014776 | 1.830 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.014029 | 1.853 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.013754 | 1.862 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.015779 | 1.802 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.016345 | 1.787 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.016345 | 1.787 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.017167 | 1.765 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.018015 | 1.744 |
| R-HSA-2262752 | Cellular responses to stress | 0.017293 | 1.762 |
| R-HSA-69481 | G2/M Checkpoints | 0.018452 | 1.734 |
| R-HSA-9707616 | Heme signaling | 0.019787 | 1.704 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.019798 | 1.703 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.028646 | 1.543 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.028646 | 1.543 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.028646 | 1.543 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.028646 | 1.543 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.028646 | 1.543 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.028646 | 1.543 |
| R-HSA-3642279 | TGFBR2 MSI Frameshift Mutants in Cancer | 0.028646 | 1.543 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.028646 | 1.543 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.028646 | 1.543 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.028646 | 1.543 |
| R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 | 0.028646 | 1.543 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.022367 | 1.650 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.020506 | 1.688 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.024676 | 1.608 |
| R-HSA-6798695 | Neutrophil degranulation | 0.023708 | 1.625 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.025589 | 1.592 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.025449 | 1.594 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.022050 | 1.657 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.025734 | 1.589 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.025449 | 1.594 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.026984 | 1.569 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.025847 | 1.588 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.023113 | 1.636 |
| R-HSA-1474165 | Reproduction | 0.020802 | 1.682 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.027930 | 1.554 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.022641 | 1.645 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.026627 | 1.575 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.028706 | 1.542 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.031686 | 1.499 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.031686 | 1.499 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.031686 | 1.499 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.031686 | 1.499 |
| R-HSA-8876725 | Protein methylation | 0.031686 | 1.499 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.033896 | 1.470 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.034596 | 1.461 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.035379 | 1.451 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.040988 | 1.387 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.040988 | 1.387 |
| R-HSA-1640170 | Cell Cycle | 0.038644 | 1.413 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.038886 | 1.410 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.039137 | 1.407 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.035171 | 1.454 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.041304 | 1.384 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.042515 | 1.371 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.042515 | 1.371 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.042662 | 1.370 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.042662 | 1.370 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.042951 | 1.367 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.044724 | 1.349 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.044724 | 1.349 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.044724 | 1.349 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.056476 | 1.248 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.056476 | 1.248 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.056476 | 1.248 |
| R-HSA-9753510 | Signaling by RAS GAP mutants | 0.056476 | 1.248 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.051060 | 1.292 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.049258 | 1.308 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.051959 | 1.284 |
| R-HSA-74160 | Gene expression (Transcription) | 0.048054 | 1.318 |
| R-HSA-212436 | Generic Transcription Pathway | 0.050799 | 1.294 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.047085 | 1.327 |
| R-HSA-72187 | mRNA 3'-end processing | 0.057973 | 1.237 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.059377 | 1.226 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.059377 | 1.226 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.059377 | 1.226 |
| R-HSA-9755088 | Ribavirin ADME | 0.059377 | 1.226 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.060297 | 1.220 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.063098 | 1.200 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.063098 | 1.200 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.063266 | 1.199 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.083511 | 1.078 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.096738 | 1.014 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.096738 | 1.014 |
| R-HSA-9645135 | STAT5 Activation | 0.122624 | 0.911 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.122624 | 0.911 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.135289 | 0.869 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.135289 | 0.869 |
| R-HSA-111995 | phospho-PLA2 pathway | 0.147772 | 0.830 |
| R-HSA-9613354 | Lipophagy | 0.160075 | 0.796 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.160075 | 0.796 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.172201 | 0.764 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.184153 | 0.735 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.218988 | 0.660 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.092660 | 1.033 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.077743 | 1.109 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.284277 | 0.546 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.085823 | 1.066 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.085823 | 1.066 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.091401 | 1.039 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.094245 | 1.026 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.304809 | 0.516 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.115130 | 0.939 |
| R-HSA-380287 | Centrosome maturation | 0.121393 | 0.916 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.099118 | 1.004 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.168381 | 0.774 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.269681 | 0.569 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.269681 | 0.569 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.175483 | 0.756 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.120347 | 0.920 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.195934 | 0.708 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.241385 | 0.617 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.120347 | 0.920 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.139789 | 0.855 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.154444 | 0.811 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.110902 | 0.955 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.122624 | 0.911 |
| R-HSA-4641265 | Repression of WNT target genes | 0.207544 | 0.683 |
| R-HSA-437239 | Recycling pathway of L1 | 0.190807 | 0.719 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.275938 | 0.559 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.083511 | 1.078 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 0.147772 | 0.830 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.230268 | 0.638 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.180391 | 0.744 |
| R-HSA-1221632 | Meiotic synapsis | 0.222473 | 0.653 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.125142 | 0.903 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.217161 | 0.663 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.083511 | 1.078 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.195934 | 0.708 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.263142 | 0.580 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.083091 | 1.080 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.092660 | 1.033 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.208058 | 0.682 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.109775 | 0.959 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.109775 | 0.959 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.135289 | 0.869 |
| R-HSA-112412 | SOS-mediated signalling | 0.135289 | 0.869 |
| R-HSA-1169092 | Activation of RAS in B cells | 0.147772 | 0.830 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.160075 | 0.796 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.195934 | 0.708 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.207544 | 0.683 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.241385 | 0.617 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.263142 | 0.580 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.129983 | 0.886 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.080398 | 1.095 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.284277 | 0.546 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.284277 | 0.546 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.324754 | 0.488 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.324754 | 0.488 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.269791 | 0.569 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.147772 | 0.830 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.207544 | 0.683 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.241385 | 0.617 |
| R-HSA-5218859 | Regulated Necrosis | 0.302668 | 0.519 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.135289 | 0.869 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.207544 | 0.683 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.324754 | 0.488 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.289278 | 0.539 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 0.172201 | 0.764 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.071293 | 1.147 |
| R-HSA-182971 | EGFR downregulation | 0.101666 | 0.993 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.109775 | 0.959 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.160075 | 0.796 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.172201 | 0.764 |
| R-HSA-171007 | p38MAPK events | 0.241385 | 0.617 |
| R-HSA-9930044 | Nuclear RNA decay | 0.110902 | 0.955 |
| R-HSA-9927020 | Heme assimilation | 0.263142 | 0.580 |
| R-HSA-9612973 | Autophagy | 0.111569 | 0.952 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.083511 | 1.078 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.096738 | 1.014 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.135289 | 0.869 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.079628 | 1.099 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.207544 | 0.683 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.230268 | 0.638 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.241385 | 0.617 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.252342 | 0.598 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.125142 | 0.903 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.263142 | 0.580 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.294617 | 0.531 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.072078 | 1.142 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.099118 | 1.004 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.151019 | 0.821 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.227795 | 0.642 |
| R-HSA-9664873 | Pexophagy | 0.172201 | 0.764 |
| R-HSA-9663891 | Selective autophagy | 0.168381 | 0.774 |
| R-HSA-1632852 | Macroautophagy | 0.199126 | 0.701 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.109775 | 0.959 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.195934 | 0.708 |
| R-HSA-8851805 | MET activates RAS signaling | 0.207544 | 0.683 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.218988 | 0.660 |
| R-HSA-2028269 | Signaling by Hippo | 0.273786 | 0.563 |
| R-HSA-167044 | Signalling to RAS | 0.314854 | 0.502 |
| R-HSA-390650 | Histamine receptors | 0.070091 | 1.154 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.160075 | 0.796 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.207544 | 0.683 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.083905 | 1.076 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.230268 | 0.638 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.263142 | 0.580 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.263142 | 0.580 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.131015 | 0.883 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.277504 | 0.557 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.185588 | 0.731 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.172884 | 0.762 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.096738 | 1.014 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.172201 | 0.764 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.184153 | 0.735 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 0.195934 | 0.708 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.195934 | 0.708 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.195934 | 0.708 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.207544 | 0.683 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.241385 | 0.617 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.263142 | 0.580 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.294617 | 0.531 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.314854 | 0.502 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.324754 | 0.488 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.190807 | 0.719 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.110902 | 0.955 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.243809 | 0.613 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.115600 | 0.937 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.324754 | 0.488 |
| R-HSA-373760 | L1CAM interactions | 0.122671 | 0.911 |
| R-HSA-112399 | IRS-mediated signalling | 0.243809 | 0.613 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.149750 | 0.825 |
| R-HSA-8953854 | Metabolism of RNA | 0.183394 | 0.737 |
| R-HSA-68882 | Mitotic Anaphase | 0.260506 | 0.584 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.120347 | 0.920 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.294617 | 0.531 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.263239 | 0.580 |
| R-HSA-9607240 | FLT3 Signaling | 0.154783 | 0.810 |
| R-HSA-447041 | CHL1 interactions | 0.135289 | 0.869 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.184153 | 0.735 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.207544 | 0.683 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.230268 | 0.638 |
| R-HSA-9678110 | Attachment and Entry | 0.252342 | 0.598 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.273786 | 0.563 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.144751 | 0.839 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.284277 | 0.546 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.304809 | 0.516 |
| R-HSA-9766229 | Degradation of CDH1 | 0.201301 | 0.696 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.103828 | 0.984 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.234861 | 0.629 |
| R-HSA-416476 | G alpha (q) signalling events | 0.122463 | 0.912 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.235503 | 0.628 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.129474 | 0.888 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.160187 | 0.795 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.252342 | 0.598 |
| R-HSA-9945266 | Differentiation of T cells | 0.252342 | 0.598 |
| R-HSA-112043 | PLC beta mediated events | 0.265225 | 0.576 |
| R-HSA-5357801 | Programmed Cell Death | 0.112047 | 0.951 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.252342 | 0.598 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.284277 | 0.546 |
| R-HSA-9694614 | Attachment and Entry | 0.324754 | 0.488 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.094544 | 1.024 |
| R-HSA-195721 | Signaling by WNT | 0.317204 | 0.499 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.071293 | 1.147 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.230268 | 0.638 |
| R-HSA-449836 | Other interleukin signaling | 0.294617 | 0.531 |
| R-HSA-157579 | Telomere Maintenance | 0.208391 | 0.681 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.281293 | 0.551 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.172201 | 0.764 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.207544 | 0.683 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 0.218988 | 0.660 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.094245 | 1.026 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.304809 | 0.516 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.265225 | 0.576 |
| R-HSA-69275 | G2/M Transition | 0.180115 | 0.744 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.286644 | 0.543 |
| R-HSA-73886 | Chromosome Maintenance | 0.312925 | 0.505 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.184998 | 0.733 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.304809 | 0.516 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.112046 | 0.951 |
| R-HSA-9659379 | Sensory processing of sound | 0.134281 | 0.872 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.324754 | 0.488 |
| R-HSA-112040 | G-protein mediated events | 0.297332 | 0.527 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.207544 | 0.683 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.230268 | 0.638 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.230268 | 0.638 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.241385 | 0.617 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.284277 | 0.546 |
| R-HSA-1237112 | Methionine salvage pathway | 0.294617 | 0.531 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.100040 | 1.000 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.265225 | 0.576 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.231402 | 0.636 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.284277 | 0.546 |
| R-HSA-2559583 | Cellular Senescence | 0.165770 | 0.780 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.232410 | 0.634 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.208391 | 0.681 |
| R-HSA-73887 | Death Receptor Signaling | 0.241719 | 0.617 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.147772 | 0.830 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.207544 | 0.683 |
| R-HSA-186763 | Downstream signal transduction | 0.101666 | 0.993 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.241385 | 0.617 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.243809 | 0.613 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.281293 | 0.551 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.207544 | 0.683 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.220450 | 0.657 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.273786 | 0.563 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.273786 | 0.563 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.284277 | 0.546 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.294617 | 0.531 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.159847 | 0.796 |
| R-HSA-9748787 | Azathioprine ADME | 0.206574 | 0.685 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.243213 | 0.614 |
| R-HSA-75893 | TNF signaling | 0.238464 | 0.623 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.118246 | 0.927 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 0.314854 | 0.502 |
| R-HSA-186797 | Signaling by PDGF | 0.083091 | 1.080 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.254118 | 0.595 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.294617 | 0.531 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.314854 | 0.502 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.323931 | 0.490 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.314854 | 0.502 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.314854 | 0.502 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.259868 | 0.585 |
| R-HSA-9675108 | Nervous system development | 0.170625 | 0.768 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.214444 | 0.669 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.107664 | 0.968 |
| R-HSA-109581 | Apoptosis | 0.266935 | 0.574 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.195934 | 0.708 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.230268 | 0.638 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.318629 | 0.497 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.154904 | 0.810 |
| R-HSA-422475 | Axon guidance | 0.203681 | 0.691 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.185588 | 0.731 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.095583 | 1.020 |
| R-HSA-210993 | Tie2 Signaling | 0.284277 | 0.546 |
| R-HSA-180786 | Extension of Telomeres | 0.254512 | 0.594 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.310561 | 0.508 |
| R-HSA-1266738 | Developmental Biology | 0.275642 | 0.560 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.230268 | 0.638 |
| R-HSA-418990 | Adherens junctions interactions | 0.135453 | 0.868 |
| R-HSA-421270 | Cell-cell junction organization | 0.203864 | 0.691 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.144751 | 0.839 |
| R-HSA-1500931 | Cell-Cell communication | 0.219161 | 0.659 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.110902 | 0.955 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.250247 | 0.602 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.263142 | 0.580 |
| R-HSA-446728 | Cell junction organization | 0.267344 | 0.573 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.324754 | 0.488 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.193238 | 0.714 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.184153 | 0.735 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.250247 | 0.602 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.312925 | 0.505 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.161366 | 0.792 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.238464 | 0.623 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.288107 | 0.540 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.182667 | 0.738 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.291288 | 0.536 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.144751 | 0.839 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.314854 | 0.502 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.329223 | 0.483 |
| R-HSA-4086398 | Ca2+ pathway | 0.329223 | 0.483 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.329223 | 0.483 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.334512 | 0.476 |
| R-HSA-8964038 | LDL clearance | 0.334512 | 0.476 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.339772 | 0.469 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.344130 | 0.463 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.344130 | 0.463 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.344130 | 0.463 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.344130 | 0.463 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.344130 | 0.463 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.344130 | 0.463 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.344130 | 0.463 |
| R-HSA-5689603 | UCH proteinases | 0.345028 | 0.462 |
| R-HSA-4839726 | Chromatin organization | 0.353228 | 0.452 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.353609 | 0.451 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.353609 | 0.451 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.353609 | 0.451 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.353609 | 0.451 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.353609 | 0.451 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.353609 | 0.451 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.353609 | 0.451 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.353609 | 0.451 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.353609 | 0.451 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.353609 | 0.451 |
| R-HSA-216083 | Integrin cell surface interactions | 0.355498 | 0.449 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.360711 | 0.443 |
| R-HSA-5617833 | Cilium Assembly | 0.361125 | 0.442 |
| R-HSA-3000157 | Laminin interactions | 0.362951 | 0.440 |
| R-HSA-9839394 | TGFBR3 expression | 0.362951 | 0.440 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.362951 | 0.440 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.362951 | 0.440 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.362951 | 0.440 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.362951 | 0.440 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.364213 | 0.439 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.364401 | 0.438 |
| R-HSA-9833482 | PKR-mediated signaling | 0.365908 | 0.437 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.365908 | 0.437 |
| R-HSA-68886 | M Phase | 0.370306 | 0.431 |
| R-HSA-5688426 | Deubiquitination | 0.370400 | 0.431 |
| R-HSA-68877 | Mitotic Prometaphase | 0.370952 | 0.431 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.372160 | 0.429 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.372160 | 0.429 |
| R-HSA-525793 | Myogenesis | 0.372160 | 0.429 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.372160 | 0.429 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.372160 | 0.429 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.372160 | 0.429 |
| R-HSA-913531 | Interferon Signaling | 0.372666 | 0.429 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.373516 | 0.428 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.374225 | 0.427 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.376253 | 0.425 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.381235 | 0.419 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.381235 | 0.419 |
| R-HSA-8949613 | Cristae formation | 0.381235 | 0.419 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.381235 | 0.419 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.381235 | 0.419 |
| R-HSA-201451 | Signaling by BMP | 0.381235 | 0.419 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.381235 | 0.419 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.381235 | 0.419 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.381235 | 0.419 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.381235 | 0.419 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.381400 | 0.419 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.386529 | 0.413 |
| R-HSA-109582 | Hemostasis | 0.388600 | 0.410 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.390180 | 0.409 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.390180 | 0.409 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.390180 | 0.409 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.390180 | 0.409 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.390180 | 0.409 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.390180 | 0.409 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.396731 | 0.402 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.396731 | 0.402 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.398996 | 0.399 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.398996 | 0.399 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.398996 | 0.399 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.398996 | 0.399 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.403606 | 0.394 |
| R-HSA-70268 | Pyruvate metabolism | 0.406855 | 0.391 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.407686 | 0.390 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.407686 | 0.390 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.407686 | 0.390 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.407686 | 0.390 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.407686 | 0.390 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.407686 | 0.390 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.407686 | 0.390 |
| R-HSA-2424491 | DAP12 signaling | 0.407686 | 0.390 |
| R-HSA-72172 | mRNA Splicing | 0.410106 | 0.387 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.411016 | 0.386 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.411886 | 0.385 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.416250 | 0.381 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.416250 | 0.381 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.416250 | 0.381 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.416250 | 0.381 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.424691 | 0.372 |
| R-HSA-69190 | DNA strand elongation | 0.424691 | 0.372 |
| R-HSA-2024096 | HS-GAG degradation | 0.424691 | 0.372 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.424691 | 0.372 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.424691 | 0.372 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.431796 | 0.365 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.433010 | 0.364 |
| R-HSA-9733709 | Cardiogenesis | 0.433010 | 0.364 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.433010 | 0.364 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.433010 | 0.364 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.433010 | 0.364 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.433010 | 0.364 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.434037 | 0.362 |
| R-HSA-397014 | Muscle contraction | 0.435947 | 0.361 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.436718 | 0.360 |
| R-HSA-390522 | Striated Muscle Contraction | 0.441210 | 0.355 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.441210 | 0.355 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.441210 | 0.355 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.441210 | 0.355 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.441210 | 0.355 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.441210 | 0.355 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.449291 | 0.347 |
| R-HSA-5673000 | RAF activation | 0.449291 | 0.347 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.449291 | 0.347 |
| R-HSA-5205647 | Mitophagy | 0.449291 | 0.347 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.449291 | 0.347 |
| R-HSA-392518 | Signal amplification | 0.449291 | 0.347 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.457256 | 0.340 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.457256 | 0.340 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.457256 | 0.340 |
| R-HSA-187687 | Signalling to ERKs | 0.457256 | 0.340 |
| R-HSA-381042 | PERK regulates gene expression | 0.457256 | 0.340 |
| R-HSA-1989781 | PPARA activates gene expression | 0.460468 | 0.337 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.460974 | 0.336 |
| R-HSA-1296071 | Potassium Channels | 0.460974 | 0.336 |
| R-HSA-8951664 | Neddylation | 0.464632 | 0.333 |
| R-HSA-8853659 | RET signaling | 0.465107 | 0.332 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.467924 | 0.330 |
| R-HSA-162587 | HIV Life Cycle | 0.467924 | 0.330 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.472844 | 0.325 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.472844 | 0.325 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.472844 | 0.325 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.475234 | 0.323 |
| R-HSA-3214847 | HATs acetylate histones | 0.475234 | 0.323 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.479937 | 0.319 |
| R-HSA-70171 | Glycolysis | 0.479937 | 0.319 |
| R-HSA-162582 | Signal Transduction | 0.480222 | 0.319 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.480470 | 0.318 |
| R-HSA-1566948 | Elastic fibre formation | 0.480470 | 0.318 |
| R-HSA-9931953 | Biofilm formation | 0.480470 | 0.318 |
| R-HSA-74217 | Purine salvage | 0.480470 | 0.318 |
| R-HSA-8875878 | MET promotes cell motility | 0.480470 | 0.318 |
| R-HSA-72766 | Translation | 0.480831 | 0.318 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.482359 | 0.317 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.484614 | 0.315 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.484614 | 0.315 |
| R-HSA-9648002 | RAS processing | 0.487986 | 0.312 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.487986 | 0.312 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.487986 | 0.312 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.487986 | 0.312 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.487986 | 0.312 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.489265 | 0.310 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.489265 | 0.310 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.493650 | 0.307 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.495394 | 0.305 |
| R-HSA-3371568 | Attenuation phase | 0.495394 | 0.305 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.495394 | 0.305 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.495394 | 0.305 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.495394 | 0.305 |
| R-HSA-9646399 | Aggrephagy | 0.495394 | 0.305 |
| R-HSA-167169 | HIV Transcription Elongation | 0.495394 | 0.305 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.495394 | 0.305 |
| R-HSA-202433 | Generation of second messenger molecules | 0.495394 | 0.305 |
| R-HSA-168249 | Innate Immune System | 0.497909 | 0.303 |
| R-HSA-168256 | Immune System | 0.498422 | 0.302 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.498487 | 0.302 |
| R-HSA-111885 | Opioid Signalling | 0.498487 | 0.302 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.502695 | 0.299 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.502695 | 0.299 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.502695 | 0.299 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.507603 | 0.294 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.507603 | 0.294 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.509891 | 0.293 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.509891 | 0.293 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.509891 | 0.293 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.509891 | 0.293 |
| R-HSA-15869 | Metabolism of nucleotides | 0.511224 | 0.291 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.512121 | 0.291 |
| R-HSA-418346 | Platelet homeostasis | 0.512121 | 0.291 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.516611 | 0.287 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.516983 | 0.287 |
| R-HSA-111996 | Ca-dependent events | 0.516983 | 0.287 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.516983 | 0.287 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.516983 | 0.287 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.523973 | 0.281 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.525510 | 0.279 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.525798 | 0.279 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.529917 | 0.276 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.529917 | 0.276 |
| R-HSA-2172127 | DAP12 interactions | 0.530862 | 0.275 |
| R-HSA-373752 | Netrin-1 signaling | 0.530862 | 0.275 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.530862 | 0.275 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.536264 | 0.271 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.537652 | 0.269 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.537652 | 0.269 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.544344 | 0.264 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.544344 | 0.264 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.544344 | 0.264 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.544344 | 0.264 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.544344 | 0.264 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.544344 | 0.264 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.544344 | 0.264 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.544344 | 0.264 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.550940 | 0.259 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.550940 | 0.259 |
| R-HSA-1483191 | Synthesis of PC | 0.550940 | 0.259 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.559989 | 0.252 |
| R-HSA-73893 | DNA Damage Bypass | 0.563847 | 0.249 |
| R-HSA-597592 | Post-translational protein modification | 0.566597 | 0.247 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.568326 | 0.245 |
| R-HSA-70326 | Glucose metabolism | 0.568326 | 0.245 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.570162 | 0.244 |
| R-HSA-109704 | PI3K Cascade | 0.570162 | 0.244 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.570162 | 0.244 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.576385 | 0.239 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.576549 | 0.239 |
| R-HSA-1474244 | Extracellular matrix organization | 0.579054 | 0.237 |
| R-HSA-68875 | Mitotic Prophase | 0.580618 | 0.236 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.582519 | 0.235 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.582519 | 0.235 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.582519 | 0.235 |
| R-HSA-983712 | Ion channel transport | 0.583320 | 0.234 |
| R-HSA-3371556 | Cellular response to heat stress | 0.584658 | 0.233 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.584658 | 0.233 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.588564 | 0.230 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.588564 | 0.230 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.588564 | 0.230 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.588564 | 0.230 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.600394 | 0.222 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.600394 | 0.222 |
| R-HSA-9679506 | SARS-CoV Infections | 0.600715 | 0.221 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.603889 | 0.219 |
| R-HSA-194138 | Signaling by VEGF | 0.604427 | 0.219 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.606182 | 0.217 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.606182 | 0.217 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.606182 | 0.217 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.606182 | 0.217 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.606182 | 0.217 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.606182 | 0.217 |
| R-HSA-1483166 | Synthesis of PA | 0.611886 | 0.213 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.615945 | 0.210 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.617508 | 0.209 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.618110 | 0.209 |
| R-HSA-191859 | snRNP Assembly | 0.623048 | 0.205 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.623048 | 0.205 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.623048 | 0.205 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.623048 | 0.205 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.623048 | 0.205 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.627252 | 0.203 |
| R-HSA-379724 | tRNA Aminoacylation | 0.628509 | 0.202 |
| R-HSA-983189 | Kinesins | 0.628509 | 0.202 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.628509 | 0.202 |
| R-HSA-1442490 | Collagen degradation | 0.633891 | 0.198 |
| R-HSA-211976 | Endogenous sterols | 0.633891 | 0.198 |
| R-HSA-8956321 | Nucleotide salvage | 0.633891 | 0.198 |
| R-HSA-9909396 | Circadian clock | 0.634569 | 0.198 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.639196 | 0.194 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.644423 | 0.191 |
| R-HSA-8848021 | Signaling by PTK6 | 0.644423 | 0.191 |
| R-HSA-211981 | Xenobiotics | 0.649576 | 0.187 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.652482 | 0.185 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.654654 | 0.184 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.655980 | 0.183 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.664591 | 0.177 |
| R-HSA-167172 | Transcription of the HIV genome | 0.669452 | 0.174 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.676381 | 0.170 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.678966 | 0.168 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.678966 | 0.168 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.678966 | 0.168 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.678966 | 0.168 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.683620 | 0.165 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.683620 | 0.165 |
| R-HSA-9638482 | Metal ion assimilation from the host | 0.683620 | 0.165 |
| R-HSA-3000178 | ECM proteoglycans | 0.683620 | 0.165 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.683620 | 0.165 |
| R-HSA-392499 | Metabolism of proteins | 0.690576 | 0.161 |
| R-HSA-1280218 | Adaptive Immune System | 0.691030 | 0.161 |
| R-HSA-166520 | Signaling by NTRKs | 0.695791 | 0.158 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.697182 | 0.157 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.697182 | 0.157 |
| R-HSA-162906 | HIV Infection | 0.697533 | 0.156 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.701573 | 0.154 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.708192 | 0.150 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.714233 | 0.146 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.714369 | 0.146 |
| R-HSA-112316 | Neuronal System | 0.716632 | 0.145 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.722594 | 0.141 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.722594 | 0.141 |
| R-HSA-8939211 | ESR-mediated signaling | 0.722696 | 0.141 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.726618 | 0.139 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.738345 | 0.132 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.742141 | 0.130 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.742141 | 0.130 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.742888 | 0.129 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.745883 | 0.127 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.749570 | 0.125 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.749570 | 0.125 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.753204 | 0.123 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.753204 | 0.123 |
| R-HSA-156902 | Peptide chain elongation | 0.756786 | 0.121 |
| R-HSA-73884 | Base Excision Repair | 0.763795 | 0.117 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.763795 | 0.117 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.765987 | 0.116 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.767223 | 0.115 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.769057 | 0.114 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.773135 | 0.112 |
| R-HSA-391251 | Protein folding | 0.773933 | 0.111 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.773933 | 0.111 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.773933 | 0.111 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.780449 | 0.108 |
| R-HSA-1474290 | Collagen formation | 0.780449 | 0.108 |
| R-HSA-611105 | Respiratory electron transport | 0.781255 | 0.107 |
| R-HSA-168255 | Influenza Infection | 0.783626 | 0.106 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.783637 | 0.106 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.786779 | 0.104 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.786779 | 0.104 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.786779 | 0.104 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.789875 | 0.102 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.789875 | 0.102 |
| R-HSA-190236 | Signaling by FGFR | 0.795934 | 0.099 |
| R-HSA-422356 | Regulation of insulin secretion | 0.795934 | 0.099 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.795934 | 0.099 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.795934 | 0.099 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.795934 | 0.099 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.798898 | 0.098 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.804698 | 0.094 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.807535 | 0.093 |
| R-HSA-192823 | Viral mRNA Translation | 0.810331 | 0.091 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.813087 | 0.090 |
| R-HSA-388396 | GPCR downstream signalling | 0.820186 | 0.086 |
| R-HSA-69239 | Synthesis of DNA | 0.823717 | 0.084 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.826279 | 0.083 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.826279 | 0.083 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.826279 | 0.083 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.828804 | 0.082 |
| R-HSA-428157 | Sphingolipid metabolism | 0.830366 | 0.081 |
| R-HSA-202403 | TCR signaling | 0.831292 | 0.080 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.831292 | 0.080 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.834131 | 0.079 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.834131 | 0.079 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.836161 | 0.078 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.836161 | 0.078 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.838543 | 0.076 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.845484 | 0.073 |
| R-HSA-1643685 | Disease | 0.847056 | 0.072 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.847731 | 0.072 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.849778 | 0.071 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.851853 | 0.070 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.852128 | 0.069 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.852128 | 0.069 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.854278 | 0.068 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.854960 | 0.068 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.856398 | 0.067 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.856398 | 0.067 |
| R-HSA-9824446 | Viral Infection Pathways | 0.857667 | 0.067 |
| R-HSA-9748784 | Drug ADME | 0.861643 | 0.065 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.862574 | 0.064 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.862574 | 0.064 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.864573 | 0.063 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.866544 | 0.062 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.866544 | 0.062 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.876734 | 0.057 |
| R-HSA-8957322 | Metabolism of steroids | 0.877961 | 0.057 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.879560 | 0.056 |
| R-HSA-72312 | rRNA processing | 0.882232 | 0.054 |
| R-HSA-9843745 | Adipogenesis | 0.883041 | 0.054 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.888875 | 0.051 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.892895 | 0.049 |
| R-HSA-163685 | Integration of energy metabolism | 0.892895 | 0.049 |
| R-HSA-372790 | Signaling by GPCR | 0.895271 | 0.048 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.895992 | 0.048 |
| R-HSA-6807070 | PTEN Regulation | 0.897507 | 0.047 |
| R-HSA-9664407 | Parasite infection | 0.899000 | 0.046 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.899000 | 0.046 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.899000 | 0.046 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.900471 | 0.046 |
| R-HSA-69242 | S Phase | 0.911499 | 0.040 |
| R-HSA-9758941 | Gastrulation | 0.912789 | 0.040 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.914060 | 0.039 |
| R-HSA-2142753 | Arachidonate metabolism | 0.916548 | 0.038 |
| R-HSA-69306 | DNA Replication | 0.917764 | 0.037 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.918112 | 0.037 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.920145 | 0.036 |
| R-HSA-9711097 | Cellular response to starvation | 0.923588 | 0.035 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.923588 | 0.035 |
| R-HSA-877300 | Interferon gamma signaling | 0.924702 | 0.034 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.928232 | 0.032 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.933055 | 0.030 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.934370 | 0.029 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.934811 | 0.029 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.936878 | 0.028 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.937800 | 0.028 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.940484 | 0.027 |
| R-HSA-1483257 | Phospholipid metabolism | 0.944302 | 0.025 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.944302 | 0.025 |
| R-HSA-5663205 | Infectious disease | 0.946662 | 0.024 |
| R-HSA-418594 | G alpha (i) signalling events | 0.949293 | 0.023 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.950117 | 0.022 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.951564 | 0.022 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.955002 | 0.020 |
| R-HSA-9609690 | HCMV Early Events | 0.956946 | 0.019 |
| R-HSA-6805567 | Keratinization | 0.963388 | 0.016 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.968791 | 0.014 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.970165 | 0.013 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.970681 | 0.013 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.973920 | 0.011 |
| R-HSA-157118 | Signaling by NOTCH | 0.977830 | 0.010 |
| R-HSA-500792 | GPCR ligand binding | 0.978445 | 0.009 |
| R-HSA-9609646 | HCMV Infection | 0.980875 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.984629 | 0.007 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.987361 | 0.006 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.987910 | 0.005 |
| R-HSA-9658195 | Leishmania infection | 0.987910 | 0.005 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.989261 | 0.005 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.990319 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 0.991550 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995608 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998170 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999678 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999877 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999992 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999995 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999998 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.877 | 0.127 | 2 | 0.863 |
CDC7 |
0.874 | 0.206 | 1 | 0.882 |
PIM3 |
0.874 | 0.205 | -3 | 0.904 |
CLK3 |
0.871 | 0.198 | 1 | 0.824 |
RSK2 |
0.869 | 0.210 | -3 | 0.854 |
CAMK1B |
0.867 | 0.166 | -3 | 0.933 |
AMPKA1 |
0.867 | 0.242 | -3 | 0.922 |
PIM1 |
0.867 | 0.233 | -3 | 0.873 |
NDR2 |
0.867 | 0.121 | -3 | 0.907 |
PRKD2 |
0.865 | 0.199 | -3 | 0.852 |
MARK4 |
0.865 | 0.197 | 4 | 0.874 |
MOS |
0.864 | 0.099 | 1 | 0.893 |
NUAK2 |
0.863 | 0.174 | -3 | 0.922 |
PRKD1 |
0.863 | 0.151 | -3 | 0.871 |
AMPKA2 |
0.863 | 0.228 | -3 | 0.901 |
PKN3 |
0.862 | 0.109 | -3 | 0.904 |
PRPK |
0.862 | -0.097 | -1 | 0.874 |
RAF1 |
0.862 | -0.014 | 1 | 0.878 |
P90RSK |
0.862 | 0.157 | -3 | 0.854 |
DSTYK |
0.862 | 0.047 | 2 | 0.884 |
NDR1 |
0.862 | 0.110 | -3 | 0.907 |
CDKL1 |
0.862 | 0.122 | -3 | 0.879 |
IKKB |
0.862 | -0.011 | -2 | 0.713 |
TSSK1 |
0.861 | 0.235 | -3 | 0.928 |
TGFBR2 |
0.860 | 0.097 | -2 | 0.830 |
TBK1 |
0.860 | -0.020 | 1 | 0.782 |
MAPKAPK2 |
0.860 | 0.196 | -3 | 0.813 |
MAPKAPK3 |
0.859 | 0.149 | -3 | 0.849 |
RSK3 |
0.859 | 0.145 | -3 | 0.852 |
MST4 |
0.859 | 0.086 | 2 | 0.859 |
TSSK2 |
0.859 | 0.190 | -5 | 0.876 |
GCN2 |
0.858 | -0.128 | 2 | 0.803 |
PKCD |
0.858 | 0.135 | 2 | 0.808 |
QSK |
0.858 | 0.220 | 4 | 0.862 |
CAMK2G |
0.858 | 0.006 | 2 | 0.818 |
NIK |
0.858 | 0.104 | -3 | 0.939 |
SRPK1 |
0.858 | 0.132 | -3 | 0.833 |
LATS2 |
0.857 | 0.114 | -5 | 0.802 |
WNK1 |
0.857 | 0.056 | -2 | 0.831 |
BMPR2 |
0.857 | -0.016 | -2 | 0.877 |
CDKL5 |
0.857 | 0.112 | -3 | 0.866 |
NLK |
0.857 | -0.006 | 1 | 0.818 |
PDHK4 |
0.857 | -0.184 | 1 | 0.869 |
SKMLCK |
0.856 | 0.111 | -2 | 0.820 |
NEK6 |
0.856 | 0.030 | -2 | 0.872 |
P70S6KB |
0.856 | 0.137 | -3 | 0.885 |
SIK |
0.856 | 0.207 | -3 | 0.860 |
CAMLCK |
0.856 | 0.084 | -2 | 0.838 |
PKACG |
0.856 | 0.130 | -2 | 0.761 |
IKKE |
0.856 | -0.046 | 1 | 0.784 |
BRSK1 |
0.856 | 0.219 | -3 | 0.880 |
PKN2 |
0.855 | 0.091 | -3 | 0.914 |
ULK2 |
0.855 | -0.120 | 2 | 0.791 |
ATR |
0.855 | -0.018 | 1 | 0.814 |
MTOR |
0.855 | -0.120 | 1 | 0.787 |
SRPK2 |
0.855 | 0.150 | -3 | 0.771 |
PDHK1 |
0.855 | -0.091 | 1 | 0.868 |
FAM20C |
0.855 | 0.194 | 2 | 0.664 |
CAMK2D |
0.855 | 0.086 | -3 | 0.899 |
NEK7 |
0.854 | -0.045 | -3 | 0.867 |
AURC |
0.853 | 0.113 | -2 | 0.674 |
CAMK2B |
0.853 | 0.175 | 2 | 0.793 |
MARK3 |
0.853 | 0.225 | 4 | 0.831 |
HIPK4 |
0.852 | 0.064 | 1 | 0.770 |
GRK6 |
0.852 | 0.115 | 1 | 0.866 |
RSK4 |
0.852 | 0.181 | -3 | 0.836 |
DAPK2 |
0.852 | 0.069 | -3 | 0.928 |
MARK2 |
0.852 | 0.221 | 4 | 0.799 |
NUAK1 |
0.852 | 0.119 | -3 | 0.887 |
PRKD3 |
0.851 | 0.146 | -3 | 0.839 |
BCKDK |
0.851 | 0.014 | -1 | 0.816 |
QIK |
0.851 | 0.119 | -3 | 0.905 |
LATS1 |
0.851 | 0.211 | -3 | 0.899 |
RIPK3 |
0.851 | -0.081 | 3 | 0.655 |
ICK |
0.850 | 0.082 | -3 | 0.900 |
HUNK |
0.850 | 0.013 | 2 | 0.787 |
CAMK4 |
0.850 | 0.071 | -3 | 0.907 |
GRK5 |
0.850 | -0.038 | -3 | 0.887 |
MLK1 |
0.850 | -0.068 | 2 | 0.819 |
ERK5 |
0.850 | -0.020 | 1 | 0.788 |
CAMK2A |
0.849 | 0.158 | 2 | 0.800 |
SRPK3 |
0.849 | 0.127 | -3 | 0.819 |
PRKX |
0.849 | 0.225 | -3 | 0.793 |
MELK |
0.849 | 0.114 | -3 | 0.885 |
PKACB |
0.849 | 0.167 | -2 | 0.699 |
MARK1 |
0.849 | 0.229 | 4 | 0.841 |
BRSK2 |
0.848 | 0.114 | -3 | 0.893 |
NIM1 |
0.848 | 0.009 | 3 | 0.723 |
WNK3 |
0.847 | -0.131 | 1 | 0.838 |
IKKA |
0.847 | 0.009 | -2 | 0.698 |
GRK1 |
0.847 | 0.073 | -2 | 0.720 |
BMPR1B |
0.847 | 0.175 | 1 | 0.844 |
MSK2 |
0.847 | 0.079 | -3 | 0.825 |
PKG2 |
0.846 | 0.139 | -2 | 0.713 |
AURB |
0.846 | 0.085 | -2 | 0.668 |
CHK1 |
0.845 | 0.145 | -3 | 0.886 |
PIM2 |
0.845 | 0.166 | -3 | 0.842 |
ULK1 |
0.845 | -0.151 | -3 | 0.841 |
CHAK2 |
0.844 | -0.082 | -1 | 0.852 |
PLK1 |
0.844 | 0.109 | -2 | 0.857 |
PKCB |
0.844 | 0.081 | 2 | 0.758 |
NEK9 |
0.844 | -0.105 | 2 | 0.844 |
MYLK4 |
0.844 | 0.099 | -2 | 0.758 |
MSK1 |
0.844 | 0.116 | -3 | 0.830 |
KIS |
0.844 | -0.002 | 1 | 0.668 |
CLK4 |
0.844 | 0.116 | -3 | 0.865 |
CLK1 |
0.844 | 0.134 | -3 | 0.848 |
PKCA |
0.844 | 0.071 | 2 | 0.756 |
PAK1 |
0.843 | 0.040 | -2 | 0.765 |
PKCG |
0.842 | 0.052 | 2 | 0.749 |
AKT2 |
0.842 | 0.146 | -3 | 0.795 |
MNK2 |
0.842 | 0.042 | -2 | 0.787 |
PAK3 |
0.842 | 0.004 | -2 | 0.768 |
SGK3 |
0.842 | 0.143 | -3 | 0.849 |
ACVR2A |
0.841 | 0.147 | -2 | 0.830 |
IRE2 |
0.841 | -0.026 | 2 | 0.764 |
PKR |
0.841 | 0.032 | 1 | 0.849 |
DLK |
0.841 | -0.104 | 1 | 0.858 |
ATM |
0.841 | -0.010 | 1 | 0.754 |
ANKRD3 |
0.841 | -0.100 | 1 | 0.871 |
PAK6 |
0.841 | 0.077 | -2 | 0.704 |
ALK4 |
0.841 | 0.031 | -2 | 0.809 |
PHKG1 |
0.841 | 0.017 | -3 | 0.900 |
MASTL |
0.840 | -0.245 | -2 | 0.783 |
IRE1 |
0.840 | -0.085 | 1 | 0.796 |
GRK4 |
0.840 | -0.057 | -2 | 0.785 |
TGFBR1 |
0.839 | 0.065 | -2 | 0.779 |
MNK1 |
0.839 | 0.073 | -2 | 0.802 |
ACVR2B |
0.839 | 0.132 | -2 | 0.831 |
SSTK |
0.839 | 0.175 | 4 | 0.841 |
MLK2 |
0.838 | -0.144 | 2 | 0.825 |
PKCH |
0.838 | 0.040 | 2 | 0.742 |
GRK7 |
0.837 | 0.091 | 1 | 0.782 |
ALK2 |
0.837 | 0.108 | -2 | 0.790 |
MLK3 |
0.837 | -0.043 | 2 | 0.759 |
NEK2 |
0.837 | -0.046 | 2 | 0.822 |
PKACA |
0.836 | 0.152 | -2 | 0.662 |
RIPK1 |
0.836 | -0.195 | 1 | 0.818 |
PLK3 |
0.836 | 0.059 | 2 | 0.753 |
TTBK2 |
0.836 | -0.143 | 2 | 0.691 |
YSK4 |
0.836 | -0.057 | 1 | 0.815 |
PAK2 |
0.836 | -0.003 | -2 | 0.749 |
CLK2 |
0.835 | 0.144 | -3 | 0.845 |
AURA |
0.835 | 0.047 | -2 | 0.627 |
CAMK1D |
0.835 | 0.165 | -3 | 0.798 |
CAMK1G |
0.835 | 0.070 | -3 | 0.861 |
CDK8 |
0.834 | -0.047 | 1 | 0.648 |
AKT1 |
0.834 | 0.134 | -3 | 0.809 |
PKCZ |
0.834 | -0.018 | 2 | 0.793 |
MEK1 |
0.833 | -0.113 | 2 | 0.820 |
DCAMKL1 |
0.832 | 0.088 | -3 | 0.874 |
DYRK2 |
0.832 | 0.010 | 1 | 0.667 |
BMPR1A |
0.832 | 0.155 | 1 | 0.833 |
P70S6K |
0.832 | 0.095 | -3 | 0.806 |
SNRK |
0.832 | -0.086 | 2 | 0.678 |
MLK4 |
0.831 | -0.063 | 2 | 0.734 |
HRI |
0.831 | -0.036 | -2 | 0.878 |
CDK7 |
0.831 | -0.046 | 1 | 0.648 |
PHKG2 |
0.831 | 0.044 | -3 | 0.894 |
CHAK1 |
0.830 | -0.133 | 2 | 0.775 |
SMMLCK |
0.830 | 0.070 | -3 | 0.900 |
PERK |
0.830 | -0.032 | -2 | 0.856 |
CDK5 |
0.830 | -0.008 | 1 | 0.664 |
VRK2 |
0.828 | -0.272 | 1 | 0.876 |
PKCT |
0.828 | 0.036 | 2 | 0.754 |
BRAF |
0.828 | -0.025 | -4 | 0.811 |
CDK19 |
0.828 | -0.048 | 1 | 0.605 |
MAPKAPK5 |
0.828 | -0.028 | -3 | 0.797 |
JNK2 |
0.827 | 0.023 | 1 | 0.588 |
DNAPK |
0.827 | -0.022 | 1 | 0.686 |
HIPK1 |
0.827 | 0.051 | 1 | 0.686 |
CDK1 |
0.827 | -0.001 | 1 | 0.596 |
WNK4 |
0.827 | -0.062 | -2 | 0.821 |
DCAMKL2 |
0.826 | 0.043 | -3 | 0.896 |
SMG1 |
0.826 | -0.086 | 1 | 0.756 |
TLK2 |
0.825 | -0.081 | 1 | 0.823 |
DYRK1A |
0.825 | 0.039 | 1 | 0.713 |
JNK3 |
0.825 | -0.001 | 1 | 0.623 |
PLK4 |
0.824 | -0.071 | 2 | 0.617 |
MEKK1 |
0.824 | -0.129 | 1 | 0.842 |
IRAK4 |
0.824 | -0.094 | 1 | 0.810 |
P38A |
0.824 | -0.030 | 1 | 0.676 |
CDK2 |
0.824 | -0.026 | 1 | 0.681 |
MEKK2 |
0.823 | -0.065 | 2 | 0.803 |
HIPK2 |
0.823 | 0.041 | 1 | 0.575 |
MST3 |
0.823 | 0.001 | 2 | 0.830 |
GRK2 |
0.823 | -0.048 | -2 | 0.662 |
CAMK1A |
0.823 | 0.146 | -3 | 0.767 |
CDK18 |
0.823 | -0.022 | 1 | 0.567 |
MEK5 |
0.823 | -0.208 | 2 | 0.818 |
PKCE |
0.822 | 0.090 | 2 | 0.739 |
PASK |
0.822 | 0.060 | -3 | 0.914 |
MEKK3 |
0.822 | -0.126 | 1 | 0.830 |
AKT3 |
0.822 | 0.140 | -3 | 0.727 |
NEK5 |
0.822 | -0.093 | 1 | 0.841 |
TAO3 |
0.822 | -0.004 | 1 | 0.822 |
PKCI |
0.821 | 0.013 | 2 | 0.758 |
CK2A2 |
0.821 | 0.135 | 1 | 0.735 |
ZAK |
0.821 | -0.136 | 1 | 0.817 |
TLK1 |
0.821 | -0.063 | -2 | 0.820 |
DRAK1 |
0.821 | -0.098 | 1 | 0.764 |
PAK5 |
0.821 | 0.024 | -2 | 0.632 |
SGK1 |
0.820 | 0.155 | -3 | 0.715 |
DAPK3 |
0.820 | 0.099 | -3 | 0.890 |
HIPK3 |
0.820 | 0.004 | 1 | 0.693 |
MRCKB |
0.820 | 0.138 | -3 | 0.844 |
PINK1 |
0.820 | -0.177 | 1 | 0.820 |
MRCKA |
0.820 | 0.137 | -3 | 0.854 |
CDK13 |
0.820 | -0.085 | 1 | 0.616 |
P38B |
0.819 | -0.015 | 1 | 0.599 |
PKN1 |
0.819 | 0.067 | -3 | 0.819 |
PRP4 |
0.819 | -0.036 | -3 | 0.767 |
CDK3 |
0.818 | 0.031 | 1 | 0.532 |
ROCK2 |
0.818 | 0.156 | -3 | 0.874 |
CDK14 |
0.817 | -0.009 | 1 | 0.614 |
TAO2 |
0.817 | -0.031 | 2 | 0.865 |
NEK8 |
0.817 | -0.080 | 2 | 0.823 |
ERK2 |
0.817 | -0.066 | 1 | 0.634 |
CHK2 |
0.817 | 0.101 | -3 | 0.745 |
DYRK3 |
0.817 | 0.037 | 1 | 0.690 |
ERK1 |
0.817 | -0.044 | 1 | 0.590 |
CDK10 |
0.816 | 0.026 | 1 | 0.596 |
P38G |
0.816 | -0.019 | 1 | 0.508 |
EEF2K |
0.816 | 0.023 | 3 | 0.751 |
CDK9 |
0.816 | -0.084 | 1 | 0.623 |
DYRK1B |
0.816 | 0.012 | 1 | 0.622 |
CK1E |
0.816 | -0.037 | -3 | 0.592 |
CDK17 |
0.816 | -0.043 | 1 | 0.511 |
SBK |
0.815 | 0.147 | -3 | 0.679 |
PAK4 |
0.815 | 0.019 | -2 | 0.635 |
GAK |
0.815 | 0.013 | 1 | 0.849 |
MPSK1 |
0.814 | -0.043 | 1 | 0.795 |
IRAK1 |
0.813 | -0.208 | -1 | 0.762 |
GCK |
0.813 | 0.006 | 1 | 0.836 |
DAPK1 |
0.813 | 0.074 | -3 | 0.879 |
CDK12 |
0.813 | -0.080 | 1 | 0.588 |
LKB1 |
0.813 | -0.078 | -3 | 0.865 |
TNIK |
0.813 | 0.028 | 3 | 0.759 |
CAMKK1 |
0.812 | -0.145 | -2 | 0.742 |
TTBK1 |
0.812 | -0.158 | 2 | 0.610 |
DYRK4 |
0.812 | 0.002 | 1 | 0.590 |
LOK |
0.812 | 0.010 | -2 | 0.781 |
DMPK1 |
0.812 | 0.168 | -3 | 0.862 |
CDK16 |
0.812 | -0.005 | 1 | 0.529 |
HGK |
0.812 | -0.031 | 3 | 0.746 |
GSK3B |
0.811 | -0.050 | 4 | 0.418 |
PKG1 |
0.811 | 0.100 | -2 | 0.648 |
NEK4 |
0.811 | -0.107 | 1 | 0.818 |
NEK11 |
0.810 | -0.181 | 1 | 0.815 |
MINK |
0.810 | -0.033 | 1 | 0.833 |
MST2 |
0.810 | -0.054 | 1 | 0.846 |
GRK3 |
0.809 | -0.036 | -2 | 0.607 |
PLK2 |
0.809 | 0.049 | -3 | 0.834 |
PDK1 |
0.809 | -0.087 | 1 | 0.806 |
CAMKK2 |
0.809 | -0.118 | -2 | 0.740 |
GSK3A |
0.809 | -0.018 | 4 | 0.426 |
ERK7 |
0.809 | 0.011 | 2 | 0.571 |
CK1G1 |
0.808 | -0.060 | -3 | 0.585 |
CK1D |
0.808 | -0.027 | -3 | 0.539 |
CK2A1 |
0.807 | 0.080 | 1 | 0.710 |
TAK1 |
0.807 | -0.063 | 1 | 0.867 |
P38D |
0.807 | -0.012 | 1 | 0.523 |
HPK1 |
0.806 | -0.019 | 1 | 0.818 |
KHS2 |
0.806 | 0.052 | 1 | 0.825 |
NEK1 |
0.806 | -0.085 | 1 | 0.820 |
MAK |
0.806 | 0.090 | -2 | 0.714 |
CK1A2 |
0.806 | -0.030 | -3 | 0.544 |
MEKK6 |
0.805 | -0.142 | 1 | 0.830 |
LRRK2 |
0.805 | -0.122 | 2 | 0.850 |
BUB1 |
0.805 | 0.064 | -5 | 0.834 |
KHS1 |
0.805 | 0.015 | 1 | 0.817 |
CRIK |
0.805 | 0.146 | -3 | 0.796 |
MST1 |
0.805 | -0.042 | 1 | 0.828 |
MOK |
0.804 | 0.075 | 1 | 0.694 |
ROCK1 |
0.804 | 0.122 | -3 | 0.852 |
PBK |
0.803 | 0.020 | 1 | 0.776 |
MAP3K15 |
0.803 | -0.150 | 1 | 0.798 |
SLK |
0.803 | -0.047 | -2 | 0.713 |
TTK |
0.801 | 0.117 | -2 | 0.857 |
CDK6 |
0.801 | -0.036 | 1 | 0.594 |
YSK1 |
0.801 | -0.064 | 2 | 0.821 |
CDK4 |
0.800 | -0.036 | 1 | 0.573 |
PDHK3_TYR |
0.799 | 0.189 | 4 | 0.872 |
RIPK2 |
0.798 | -0.228 | 1 | 0.777 |
VRK1 |
0.798 | -0.205 | 2 | 0.819 |
JNK1 |
0.798 | -0.038 | 1 | 0.570 |
MEK2 |
0.796 | -0.231 | 2 | 0.798 |
NEK3 |
0.794 | -0.156 | 1 | 0.791 |
STK33 |
0.793 | -0.197 | 2 | 0.602 |
TESK1_TYR |
0.792 | 0.012 | 3 | 0.783 |
BIKE |
0.789 | 0.030 | 1 | 0.720 |
MAP2K4_TYR |
0.788 | -0.030 | -1 | 0.887 |
PDHK4_TYR |
0.788 | 0.042 | 2 | 0.866 |
MAP2K7_TYR |
0.788 | -0.110 | 2 | 0.853 |
HASPIN |
0.787 | -0.028 | -1 | 0.697 |
MAP2K6_TYR |
0.787 | -0.005 | -1 | 0.888 |
OSR1 |
0.787 | -0.099 | 2 | 0.795 |
PKMYT1_TYR |
0.786 | -0.102 | 3 | 0.748 |
LIMK2_TYR |
0.786 | 0.003 | -3 | 0.918 |
TAO1 |
0.786 | -0.068 | 1 | 0.762 |
MYO3B |
0.786 | -0.077 | 2 | 0.834 |
ALPHAK3 |
0.786 | 0.005 | -1 | 0.781 |
PINK1_TYR |
0.785 | -0.109 | 1 | 0.846 |
PDHK1_TYR |
0.785 | -0.016 | -1 | 0.901 |
BMPR2_TYR |
0.784 | -0.023 | -1 | 0.864 |
RET |
0.783 | -0.050 | 1 | 0.824 |
EPHA6 |
0.782 | 0.014 | -1 | 0.869 |
MYO3A |
0.782 | -0.090 | 1 | 0.806 |
ASK1 |
0.781 | -0.177 | 1 | 0.786 |
LIMK1_TYR |
0.780 | -0.137 | 2 | 0.861 |
TYK2 |
0.779 | -0.126 | 1 | 0.828 |
ROS1 |
0.778 | -0.099 | 3 | 0.659 |
EPHB4 |
0.777 | -0.034 | -1 | 0.859 |
TYRO3 |
0.777 | -0.113 | 3 | 0.687 |
MST1R |
0.776 | -0.154 | 3 | 0.692 |
DDR1 |
0.775 | -0.113 | 4 | 0.794 |
TXK |
0.775 | 0.062 | 1 | 0.860 |
JAK2 |
0.775 | -0.152 | 1 | 0.824 |
FGR |
0.774 | -0.068 | 1 | 0.865 |
TNNI3K_TYR |
0.773 | 0.002 | 1 | 0.838 |
YES1 |
0.773 | -0.038 | -1 | 0.868 |
YANK3 |
0.773 | -0.106 | 2 | 0.380 |
FER |
0.772 | -0.096 | 1 | 0.893 |
AAK1 |
0.772 | 0.059 | 1 | 0.611 |
INSRR |
0.772 | -0.069 | 3 | 0.641 |
CSF1R |
0.771 | -0.144 | 3 | 0.679 |
ABL2 |
0.770 | -0.084 | -1 | 0.834 |
LCK |
0.769 | -0.023 | -1 | 0.844 |
NEK10_TYR |
0.769 | -0.060 | 1 | 0.718 |
EPHA4 |
0.769 | -0.038 | 2 | 0.752 |
EPHB1 |
0.769 | -0.061 | 1 | 0.881 |
JAK3 |
0.769 | -0.144 | 1 | 0.804 |
PDGFRB |
0.769 | -0.136 | 3 | 0.691 |
STLK3 |
0.769 | -0.192 | 1 | 0.789 |
TNK2 |
0.768 | -0.092 | 3 | 0.636 |
EPHB3 |
0.768 | -0.060 | -1 | 0.846 |
SRMS |
0.768 | -0.056 | 1 | 0.882 |
HCK |
0.768 | -0.093 | -1 | 0.842 |
FLT3 |
0.768 | -0.122 | 3 | 0.680 |
BLK |
0.767 | 0.009 | -1 | 0.849 |
EPHB2 |
0.766 | -0.039 | -1 | 0.839 |
TNK1 |
0.766 | -0.105 | 3 | 0.670 |
ABL1 |
0.766 | -0.107 | -1 | 0.827 |
ITK |
0.766 | -0.078 | -1 | 0.814 |
JAK1 |
0.766 | -0.083 | 1 | 0.773 |
FGFR2 |
0.766 | -0.133 | 3 | 0.687 |
AXL |
0.766 | -0.104 | 3 | 0.666 |
TEC |
0.765 | -0.035 | -1 | 0.766 |
CK1A |
0.765 | -0.073 | -3 | 0.447 |
TEK |
0.765 | -0.139 | 3 | 0.633 |
KDR |
0.764 | -0.126 | 3 | 0.649 |
KIT |
0.763 | -0.163 | 3 | 0.687 |
FGFR1 |
0.762 | -0.158 | 3 | 0.658 |
ALK |
0.762 | -0.130 | 3 | 0.599 |
PDGFRA |
0.762 | -0.202 | 3 | 0.690 |
LTK |
0.761 | -0.115 | 3 | 0.627 |
BMX |
0.761 | -0.066 | -1 | 0.737 |
MERTK |
0.760 | -0.111 | 3 | 0.667 |
EPHA7 |
0.760 | -0.063 | 2 | 0.762 |
BTK |
0.760 | -0.165 | -1 | 0.784 |
PTK6 |
0.759 | -0.147 | -1 | 0.756 |
FYN |
0.757 | -0.030 | -1 | 0.818 |
DDR2 |
0.757 | -0.038 | 3 | 0.620 |
LYN |
0.756 | -0.084 | 3 | 0.618 |
WEE1_TYR |
0.756 | -0.144 | -1 | 0.762 |
NTRK1 |
0.756 | -0.191 | -1 | 0.839 |
EPHA1 |
0.756 | -0.125 | 3 | 0.636 |
FLT1 |
0.756 | -0.117 | -1 | 0.838 |
NTRK2 |
0.755 | -0.185 | 3 | 0.651 |
EPHA3 |
0.755 | -0.138 | 2 | 0.732 |
MET |
0.755 | -0.166 | 3 | 0.661 |
INSR |
0.754 | -0.164 | 3 | 0.620 |
ERBB2 |
0.754 | -0.176 | 1 | 0.782 |
FRK |
0.754 | -0.127 | -1 | 0.858 |
CK1G3 |
0.753 | -0.029 | -3 | 0.404 |
FLT4 |
0.752 | -0.185 | 3 | 0.654 |
FGFR3 |
0.752 | -0.168 | 3 | 0.664 |
EPHA5 |
0.752 | -0.069 | 2 | 0.742 |
PTK2B |
0.751 | -0.080 | -1 | 0.808 |
NTRK3 |
0.749 | -0.164 | -1 | 0.796 |
EPHA8 |
0.747 | -0.112 | -1 | 0.820 |
SRC |
0.747 | -0.096 | -1 | 0.823 |
MATK |
0.746 | -0.160 | -1 | 0.756 |
EGFR |
0.745 | -0.089 | 1 | 0.689 |
CSK |
0.743 | -0.182 | 2 | 0.763 |
PTK2 |
0.740 | -0.056 | -1 | 0.770 |
FGFR4 |
0.740 | -0.130 | -1 | 0.787 |
YANK2 |
0.739 | -0.135 | 2 | 0.401 |
IGF1R |
0.738 | -0.167 | 3 | 0.572 |
SYK |
0.737 | -0.053 | -1 | 0.772 |
EPHA2 |
0.737 | -0.119 | -1 | 0.780 |
MUSK |
0.737 | -0.184 | 1 | 0.681 |
ERBB4 |
0.730 | -0.111 | 1 | 0.707 |
CK1G2 |
0.725 | -0.097 | -3 | 0.504 |
FES |
0.721 | -0.184 | -1 | 0.717 |
ZAP70 |
0.704 | -0.146 | -1 | 0.691 |