Motif 794 (n=197)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S473 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| E9PCH4 | None | S1482 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| H0YC42 | None | S144 | ochoa | Tumor protein D52 | None |
| H0YHG0 | None | S408 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| O00522 | KRIT1 | S277 | ochoa | Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067). {ECO:0000250|UniProtKB:Q6S5J6, ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:20616044, ECO:0000269|PubMed:20668652, ECO:0000269|PubMed:21633110, ECO:0000269|PubMed:23317506, ECO:0000269|PubMed:26417067}. |
| O14523 | C2CD2L | S532 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14641 | DVL2 | S435 | psp | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14733 | MAP2K7 | S265 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14950 | MYL12B | S20 | ochoa|psp | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. {ECO:0000269|PubMed:10965042}. |
| O15265 | ATXN7 | S568 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
| O15439 | ABCC4 | S629 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43399 | TPD52L2 | S134 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43491 | EPB41L2 | S950 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43683 | BUB1 | S194 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60841 | EIF5B | S588 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75128 | COBL | S260 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75362 | ZNF217 | S247 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75369 | FLNB | S2013 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O95391 | SLU7 | S98 | ochoa | Pre-mRNA-splicing factor SLU7 (hSlu7) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15181151, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. |
| O96017 | CHEK2 | S260 | ochoa|psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| O96017 | CHEK2 | S372 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P01282 | VIP | S116 | ochoa | VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42) (PHV-42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27) (PHM-27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] | [Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3456568, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8933357}.; FUNCTION: PHM-27 and PHV-42 are two bioactive forms from proteolysis of the same precursor protein, that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}. |
| P04818 | TYMS | S114 | ochoa|psp | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}. |
| P10809 | HSPD1 | S488 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11171 | EPB41 | S812 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11940 | PABPC1 | S120 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P15336 | ATF2 | S112 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P17480 | UBTF | S584 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P19105 | MYL12A | S19 | ochoa|psp | Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}. |
| P20290 | BTF3 | S101 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P20929 | NEB | S133 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P25705 | ATP5F1A | S513 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P26378 | ELAVL4 | S228 | ochoa | ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) | RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:7898713). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:Q61701, ECO:0000269|PubMed:10710437, ECO:0000269|PubMed:12034726, ECO:0000269|PubMed:12468554, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:17234598, ECO:0000269|PubMed:18218628, ECO:0000269|PubMed:24857657, ECO:0000269|PubMed:7898713}. |
| P27694 | RPA1 | S174 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P27816 | MAP4 | S983 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29317 | EPHA2 | S761 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29320 | EPHA3 | S768 | ochoa|psp | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| P29322 | EPHA8 | S782 | ochoa | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| P29323 | EPHB2 | S768 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P30260 | CDC27 | S438 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P30304 | CDC25A | S156 | psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30414 | NKTR | S891 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P31327 | CPS1 | S863 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P35498 | SCN1A | S1918 | psp | Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) | Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14672992). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits (By similarity). Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (By similarity). {ECO:0000250|UniProtKB:A2APX8, ECO:0000269|PubMed:14672992}. |
| P36507 | MAP2K2 | S216 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P42574 | CASP3 | S26 | ochoa|psp | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}. |
| P43403 | ZAP70 | S491 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P45378 | TNNT3 | S160 | ochoa | Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P45985 | MAP2K4 | S251 | ochoa | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| P46013 | MKI67 | S411 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46100 | ATRX | S962 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49792 | RANBP2 | S1486 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P54132 | BLM | S144 | ochoa|psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54132 | BLM | S338 | ochoa|psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54132 | BLM | S1373 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54578 | USP14 | S456 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P54753 | EPHB3 | S780 | ochoa | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
| P54756 | EPHA5 | S822 | ochoa | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}. |
| P54760 | EPHB4 | S762 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P54762 | EPHB1 | S766 | ochoa | Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}. |
| P56645 | PER3 | S700 | ochoa | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
| P61289 | PSME3 | S43 | ochoa | Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}. |
| P61353 | RPL27 | S34 | ochoa | Large ribosomal subunit protein eL27 (60S ribosomal protein L27) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P62750 | RPL23A | S85 | ochoa | Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
| P63151 | PPP2R2A | S409 | ochoa | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| P82979 | SARNP | S95 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| Q00872 | MYBPC1 | S120 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q02241 | KIF23 | S889 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02750 | MAP2K1 | S212 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| Q03164 | KMT2A | S261 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05397 | PTK2 | S568 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q06187 | BTK | S543 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08345 | DDR1 | S788 | psp | Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) | Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:19401332, ECO:0000269|PubMed:20093046, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:20884741, ECO:0000269|PubMed:21044884, ECO:0000269|PubMed:9659899}. |
| Q08945 | SSRP1 | S120 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q09666 | AHNAK | S5190 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13131 | PRKAA1 | S172 | psp | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| Q13310 | PABPC4 | S120 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13415 | ORC1 | S374 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13523 | PRP4K | S277 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14156 | EFR3A | S415 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14289 | PTK2B | S571 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14596 | NBR1 | S115 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14966 | ZNF638 | S1825 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14980 | NUMA1 | S1103 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15375 | EPHA7 | S780 | ochoa | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
| Q15596 | NCOA2 | S655 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15645 | TRIP13 | S41 | ochoa | Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) | Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959). {ECO:0000250|UniProtKB:Q3UA06, ECO:0000269|PubMed:28553959}. |
| Q15785 | TOMM34 | S279 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q16891 | IMMT | S350 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2M1K9 | ZNF423 | S604 | ochoa | Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Q49A26 | GLYR1 | S152 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q4G0J3 | LARP7 | S411 | ochoa | La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}. |
| Q58EX2 | SDK2 | S1978 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5FWF5 | ESCO1 | S24 | ochoa | N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}. |
| Q5T0W9 | FAM83B | S838 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5UIP0 | RIF1 | S1189 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q66LE6 | PPP2R2D | S415 | ochoa | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity). {ECO:0000250|UniProtKB:Q7ZX64, ECO:0000250|UniProtKB:Q925E7}. |
| Q68DQ2 | CRYBG3 | S655 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q69YH5 | CDCA2 | S291 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q69YN4 | VIRMA | S1602 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6IQ49 | SDE2 | S188 | ochoa | Splicing regulator SDE2 (Replication stress response regulator SDE2) | Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959). {ECO:0000269|PubMed:27906959}.; FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (PubMed:34365507). May recruit CACTIN to the spliceosome (By similarity). {ECO:0000250|UniProtKB:O14113, ECO:0000269|PubMed:34365507}.; FUNCTION: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (PubMed:34365507). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (PubMed:34365507). {ECO:0000269|PubMed:34365507}. |
| Q6IQ55 | TTBK2 | S852 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6P3S1 | DENND1B | S596 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6PJW8 | CNST | S293 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6W4X9 | MUC6 | S936 | ochoa | Mucin-6 (MUC-6) (Gastric mucin-6) | May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}. |
| Q6ZWJ1 | STXBP4 | S163 | ochoa | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
| Q7L590 | MCM10 | S488 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q86TC9 | MYPN | S197 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86X10 | RALGAPB | S647 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q8N0Z3 | SPICE1 | S315 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N0Z3 | SPICE1 | S317 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N4C8 | MINK1 | S175 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N6T3 | ARFGAP1 | S246 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8NB50 | ZFP62 | S233 | ochoa | Zinc finger protein 62 homolog (Zfp-62) | May play a role in differentiating skeletal muscle. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S1387 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NEZ4 | KMT2C | S3800 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFC6 | BOD1L1 | S537 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHM5 | KDM2B | S477 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8TEU7 | RAPGEF6 | S1432 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WY36 | BBX | S481 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q92556 | ELMO1 | S510 | ochoa | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}. |
| Q92974 | ARHGEF2 | S107 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q96CW1 | AP2M1 | S234 | ochoa | AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) | Component of the adaptor protein complex 2 (AP-2) (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:16581796). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (PubMed:19033387). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:11877457). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (PubMed:11877457). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P84092, ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:12694563, ECO:0000269|PubMed:12952941, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:16581796, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:31104773}. |
| Q96D71 | REPS1 | S377 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96JJ3 | ELMO2 | S503 | ochoa | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:11703939, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:27476657}. |
| Q96KB5 | PBK | S23 | ochoa | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| Q96Q89 | KIF20B | S1712 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96RL1 | UIMC1 | S26 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96S90 | LYSMD1 | S166 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q96T49 | PPP1R16B | S69 | psp | Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP) | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934). {ECO:0000250|UniProtKB:Q8VHQ3, ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:25007873, ECO:0000269|PubMed:26497934}. |
| Q99700 | ATXN2 | S356 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99848 | EBNA1BP2 | S207 | ochoa | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q9BQ04 | RBM4B | S86 | ochoa | RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30) | Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). {ECO:0000250}. |
| Q9BSC4 | NOL10 | S25 | ochoa | Nucleolar protein 10 | None |
| Q9BVI0 | PHF20 | S328 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BW66 | CINP | S70 | ochoa | Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) | Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:16082200, PubMed:19889979). Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q9BWF3 | RBM4 | S86 | ochoa | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9BWT1 | CDCA7 | S138 | ochoa | Cell division cycle-associated protein 7 (Protein JPO1) | Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269|PubMed:11598121, ECO:0000269|PubMed:15994934, ECO:0000269|PubMed:16580749, ECO:0000269|PubMed:23166294}. |
| Q9BXF6 | RAB11FIP5 | S207 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BZF1 | OSBPL8 | S798 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C0A6 | SETD5 | S193 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9H0A0 | NAT10 | S67 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
| Q9H2G2 | SLK | S177 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H4G0 | EPB41L1 | S820 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H583 | HEATR1 | S1195 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9HCE3 | ZNF532 | S1069 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HDC5 | JPH1 | S625 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NPB8 | GPCPD1 | S424 | ochoa | Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) | May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. {ECO:0000250}. |
| Q9NPF5 | DMAP1 | S42 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
| Q9NQX3 | GPHN | S303 | ochoa | Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}. |
| Q9NRH2 | SNRK | S162 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
| Q9NXG2 | THUMPD1 | S295 | ochoa | THUMP domain-containing protein 1 | Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C) (PubMed:25653167, PubMed:35196516). {ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:35196516}. |
| Q9P1T7 | MDFIC | S137 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Q9P260 | RELCH | S439 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P2B7 | CFAP97 | S329 | ochoa | Cilia- and flagella-associated protein 97 | None |
| Q9P2D1 | CHD7 | S708 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UEW8 | STK39 | S315 | ochoa | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UF33 | EPHA6 | S820 | ochoa | Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}. |
| Q9UHA3 | RSL24D1 | S68 | ochoa | Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (Ribosomal protein L24-like) | Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). {ECO:0000250|UniProtKB:Q07915}. |
| Q9UIJ5 | ZDHHC2 | S333 | ochoa | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}. |
| Q9UKE5 | TNIK | S175 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKL3 | CASP8AP2 | S567 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKV3 | ACIN1 | S838 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S1094 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UL03 | INTS6 | S804 | ochoa | Integrator complex subunit 6 (Int6) (DBI-1) (Protein deleted in cancer 1) (DICE1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:34004147, PubMed:39504960). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683, PubMed:39504960). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint (PubMed:33243860, PubMed:34004147). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). {ECO:0000269|PubMed:15254679, ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:39504960}. |
| Q9ULV4 | CORO1C | S434 | ochoa | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9Y232 | CDYL | S182 | ochoa | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) | [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}. |
| Q9Y2J2 | EPB41L3 | S1031 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y3Z3 | SAMHD1 | S519 | ochoa | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}. |
| Q9Y426 | C2CD2 | S516 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y490 | TLN1 | S22 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y6R1 | SLC4A4 | S61 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| O95625 | ZBTB11 | S537 | EPSD|PSP | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P00338 | LDHA | S105 | Sugiyama | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P07195 | LDHB | S106 | Sugiyama | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P61024 | CKS1B | S41 | Sugiyama | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
| O14965 | AURKA | S278 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| P31150 | GDI1 | S316 | Sugiyama | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}. |
| P50395 | GDI2 | S316 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P13667 | PDIA4 | S126 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| Q14192 | FHL2 | S121 | Sugiyama | Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}. |
| P07949 | RET | S896 | Sugiyama | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P52888 | THOP1 | S643 | ELM|iPTMNet|EPSD | Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}. |
| Q03112 | MECOM | S624 | SIGNOR | Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) | [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}. |
| P08238 | HSP90AB1 | S417 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q8N6T3 | ARFGAP1 | S270 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| O15169 | AXIN1 | S614 | iPTMNet|EPSD | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| Q92997 | DVL3 | S263 | GPS6 | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96E11 | MRRF | S227 | Sugiyama | Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial) | Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). {ECO:0000269|PubMed:19716793, ECO:0000269|PubMed:33878294}. |
| Q9C005 | DPY30 | S50 | Sugiyama | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}. |
| P49917 | LIG4 | S199 | GPS6|ELM|iPTMNet|EPSD | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:12517771, PubMed:17290226, PubMed:23523427, PubMed:29980672, PubMed:33586762, PubMed:8798671, PubMed:9242410, PubMed:9809069). Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps (PubMed:17290226). Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 (PubMed:9242410, PubMed:9809069). Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10854421). LIG4 regulates nuclear localization of XRCC4 (PubMed:24984242). {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:23523427, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:29980672, ECO:0000269|PubMed:33586762, ECO:0000269|PubMed:8798671, ECO:0000269|PubMed:9242410, ECO:0000269|PubMed:9809069}. |
| P10636 | MAPT | S622 | SIGNOR | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| Q16816 | PHKG1 | S172 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q9Y6D6 | ARFGEF1 | S1575 | Sugiyama | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q96PF2 | TSSK2 | S153 | Sugiyama | Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B) | Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}. |
| Q9H1R3 | MYLK2 | S577 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q9NYF8 | BCLAF1 | S345 | Sugiyama | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.588331e-10 | 9.445 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.819808e-10 | 9.740 |
| R-HSA-422475 | Axon guidance | 5.986141e-08 | 7.223 |
| R-HSA-9675108 | Nervous system development | 2.019972e-07 | 6.695 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.120323e-07 | 6.385 |
| R-HSA-1640170 | Cell Cycle | 6.459299e-06 | 5.190 |
| R-HSA-3928664 | Ephrin signaling | 1.730641e-05 | 4.762 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.047652e-05 | 4.297 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.860241e-05 | 4.053 |
| R-HSA-69206 | G1/S Transition | 1.349221e-04 | 3.870 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.439752e-04 | 3.613 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.860940e-04 | 3.543 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.183595e-04 | 3.497 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.330894e-04 | 3.363 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 7.472661e-04 | 3.127 |
| R-HSA-9830364 | Formation of the nephric duct | 8.757370e-04 | 3.058 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 9.840362e-04 | 3.007 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.402408e-03 | 2.853 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 2.141911e-03 | 2.669 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.018895e-03 | 2.695 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.838619e-03 | 2.736 |
| R-HSA-69242 | S Phase | 1.987426e-03 | 2.702 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.936413e-03 | 2.713 |
| R-HSA-373760 | L1CAM interactions | 2.042511e-03 | 2.690 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.504510e-03 | 2.601 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 3.057305e-03 | 2.515 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.986808e-03 | 2.525 |
| R-HSA-69481 | G2/M Checkpoints | 3.316221e-03 | 2.479 |
| R-HSA-4839726 | Chromatin organization | 3.745513e-03 | 2.426 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.220762e-03 | 2.375 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.504493e-03 | 2.346 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 5.340457e-03 | 2.272 |
| R-HSA-75153 | Apoptotic execution phase | 6.355340e-03 | 2.197 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 6.699938e-03 | 2.174 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 6.699938e-03 | 2.174 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 1.332450e-02 | 1.875 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.647227e-02 | 1.577 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.647227e-02 | 1.577 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.647227e-02 | 1.577 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.647227e-02 | 1.577 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.647227e-02 | 1.577 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.160206e-02 | 1.935 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.765955e-02 | 1.753 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.765955e-02 | 1.753 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.477449e-02 | 1.606 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.005954e-02 | 1.522 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 1.031039e-02 | 1.987 |
| R-HSA-390522 | Striated Muscle Contraction | 1.715775e-02 | 1.766 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.892085e-02 | 1.539 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.679421e-02 | 1.572 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.679421e-02 | 1.572 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.736504e-02 | 1.563 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.031039e-02 | 1.987 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.005954e-02 | 1.522 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.958021e-02 | 1.529 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.300172e-02 | 1.886 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.892085e-02 | 1.539 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.160206e-02 | 1.935 |
| R-HSA-9664420 | Killing mechanisms | 3.005954e-02 | 1.522 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 3.005954e-02 | 1.522 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.197213e-02 | 1.658 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.265096e-02 | 1.645 |
| R-HSA-373756 | SDK interactions | 2.647227e-02 | 1.577 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.892085e-02 | 1.539 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.537811e-02 | 1.596 |
| R-HSA-9909396 | Circadian clock | 1.554775e-02 | 1.808 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.833999e-03 | 2.054 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 8.199309e-03 | 2.086 |
| R-HSA-3214847 | HATs acetylate histones | 1.705695e-02 | 1.768 |
| R-HSA-170968 | Frs2-mediated activation | 2.229115e-02 | 1.652 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 9.633073e-03 | 2.016 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 9.633073e-03 | 2.016 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.065991e-02 | 1.972 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.065991e-02 | 1.972 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.066172e-02 | 1.685 |
| R-HSA-169893 | Prolonged ERK activation events | 3.005954e-02 | 1.522 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.477449e-02 | 1.606 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.549597e-02 | 1.594 |
| R-HSA-397014 | Muscle contraction | 1.381261e-02 | 1.860 |
| R-HSA-1266738 | Developmental Biology | 1.347398e-02 | 1.871 |
| R-HSA-450294 | MAP kinase activation | 1.452549e-02 | 1.838 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.798011e-02 | 1.745 |
| R-HSA-448424 | Interleukin-17 signaling | 2.163938e-02 | 1.665 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.160206e-02 | 1.935 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.477449e-02 | 1.606 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.371875e-02 | 1.625 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.082912e-02 | 1.965 |
| R-HSA-2559583 | Cellular Senescence | 1.876471e-02 | 1.727 |
| R-HSA-6794361 | Neurexins and neuroligins | 9.107108e-03 | 2.041 |
| R-HSA-9830369 | Kidney development | 1.907134e-02 | 1.720 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.646853e-02 | 1.783 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.646853e-02 | 1.783 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.646853e-02 | 1.783 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.446508e-02 | 1.611 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.522637e-02 | 1.598 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.522637e-02 | 1.598 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.156864e-02 | 1.666 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.760092e-02 | 1.559 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.011320e-02 | 1.521 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.285479e-02 | 1.483 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.574765e-02 | 1.447 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.574765e-02 | 1.447 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.689666e-02 | 1.433 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.689666e-02 | 1.433 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.689666e-02 | 1.433 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.285479e-02 | 1.483 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.689666e-02 | 1.433 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.186556e-02 | 1.497 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.574765e-02 | 1.447 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.186556e-02 | 1.497 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.574765e-02 | 1.447 |
| R-HSA-2028269 | Signaling by Hippo | 3.574765e-02 | 1.447 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.756185e-02 | 1.425 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 3.944564e-02 | 1.404 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.873504e-02 | 1.412 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 4.823469e-02 | 1.317 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.820378e-02 | 1.317 |
| R-HSA-164939 | Nef mediated downregulation of CD28 cell surface expression | 3.944564e-02 | 1.404 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 4.823469e-02 | 1.317 |
| R-HSA-69186 | Lagging Strand Synthesis | 4.823469e-02 | 1.317 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.037050e-02 | 1.394 |
| R-HSA-445144 | Signal transduction by L1 | 4.498148e-02 | 1.347 |
| R-HSA-5358508 | Mismatch Repair | 3.873504e-02 | 1.412 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 4.498148e-02 | 1.347 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.716359e-02 | 1.326 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.873504e-02 | 1.412 |
| R-HSA-2262752 | Cellular responses to stress | 4.062871e-02 | 1.391 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.156333e-02 | 1.381 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 4.008122e-02 | 1.397 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.820378e-02 | 1.317 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.974832e-02 | 1.303 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 5.157078e-02 | 1.288 |
| R-HSA-9658195 | Leishmania infection | 5.169177e-02 | 1.287 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.169177e-02 | 1.287 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 5.224691e-02 | 1.282 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 5.224691e-02 | 1.282 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 5.498699e-02 | 1.260 |
| R-HSA-72312 | rRNA processing | 5.499384e-02 | 1.260 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.716934e-02 | 1.243 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 5.848060e-02 | 1.233 |
| R-HSA-157579 | Telomere Maintenance | 5.874488e-02 | 1.231 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 6.487836e-02 | 1.188 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 6.487836e-02 | 1.188 |
| R-HSA-8949613 | Cristae formation | 7.317706e-02 | 1.136 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 7.701912e-02 | 1.113 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.609650e-02 | 1.119 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.360948e-02 | 1.196 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 6.204898e-02 | 1.207 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 7.317706e-02 | 1.136 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.942342e-02 | 1.100 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.942342e-02 | 1.100 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 7.701912e-02 | 1.113 |
| R-HSA-69239 | Synthesis of DNA | 7.757751e-02 | 1.110 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 7.134641e-02 | 1.147 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.041435e-02 | 1.152 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 6.487836e-02 | 1.188 |
| R-HSA-205025 | NADE modulates death signalling | 7.734223e-02 | 1.112 |
| R-HSA-180786 | Extension of Telomeres | 6.226744e-02 | 1.206 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 6.939972e-02 | 1.159 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 6.487836e-02 | 1.188 |
| R-HSA-70635 | Urea cycle | 6.939972e-02 | 1.159 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 7.317706e-02 | 1.136 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.134641e-02 | 1.147 |
| R-HSA-8939211 | ESR-mediated signaling | 5.977963e-02 | 1.223 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 7.852275e-02 | 1.105 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.179117e-02 | 1.209 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.179117e-02 | 1.209 |
| R-HSA-9664407 | Parasite infection | 6.179117e-02 | 1.209 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 7.317706e-02 | 1.136 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.532441e-02 | 1.185 |
| R-HSA-373755 | Semaphorin interactions | 7.134641e-02 | 1.147 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 1.017761e-01 | 0.992 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.137503e-01 | 0.944 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.372243e-01 | 0.863 |
| R-HSA-196025 | Formation of annular gap junctions | 1.372243e-01 | 0.863 |
| R-HSA-190873 | Gap junction degradation | 1.487282e-01 | 0.828 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.487282e-01 | 0.828 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.600794e-01 | 0.796 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.712799e-01 | 0.766 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.712799e-01 | 0.766 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.712799e-01 | 0.766 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.823317e-01 | 0.739 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.932368e-01 | 0.714 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.932368e-01 | 0.714 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.932368e-01 | 0.714 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.932368e-01 | 0.714 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.932368e-01 | 0.714 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.932368e-01 | 0.714 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 8.092353e-02 | 1.092 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.146146e-01 | 0.668 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.250911e-01 | 0.648 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 2.250911e-01 | 0.648 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.354285e-01 | 0.628 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.354285e-01 | 0.628 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.354285e-01 | 0.628 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 2.354285e-01 | 0.628 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 2.354285e-01 | 0.628 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.055325e-01 | 0.977 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 9.642145e-02 | 1.016 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.215987e-01 | 0.915 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.928094e-01 | 0.715 |
| R-HSA-72187 | mRNA 3'-end processing | 1.928094e-01 | 0.715 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.928094e-01 | 0.715 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.976510e-01 | 0.704 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.976510e-01 | 0.704 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.334872e-01 | 0.875 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.334872e-01 | 0.875 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.073775e-01 | 0.683 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.122599e-01 | 0.673 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.122599e-01 | 0.673 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.520327e-01 | 0.818 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.680727e-01 | 0.775 |
| R-HSA-192823 | Viral mRNA Translation | 1.980808e-01 | 0.703 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.152774e-01 | 0.667 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.334872e-01 | 0.875 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.594438e-01 | 0.797 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.594438e-01 | 0.797 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 8.092353e-02 | 1.092 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.363625e-01 | 0.865 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.123883e-01 | 0.949 |
| R-HSA-73893 | DNA Damage Bypass | 1.783862e-01 | 0.749 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.250911e-01 | 0.648 |
| R-HSA-354192 | Integrin signaling | 9.711889e-02 | 1.013 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.250911e-01 | 0.648 |
| R-HSA-156902 | Peptide chain elongation | 1.426583e-01 | 0.846 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.932368e-01 | 0.714 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 9.114863e-02 | 1.040 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 9.114863e-02 | 1.040 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.594438e-01 | 0.797 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.220570e-01 | 0.654 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.713387e-01 | 0.766 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.719406e-01 | 0.765 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.150769e-01 | 0.667 |
| R-HSA-164843 | 2-LTR circle formation | 1.600794e-01 | 0.796 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 9.711889e-02 | 1.013 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.455045e-01 | 0.837 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.304777e-01 | 0.884 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.186905e-01 | 0.926 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.292746e-01 | 0.640 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.095160e-02 | 1.041 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.017761e-01 | 0.992 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.255657e-01 | 0.901 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 9.298784e-02 | 1.032 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.713387e-01 | 0.766 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 8.098256e-02 | 1.092 |
| R-HSA-4086400 | PCP/CE pathway | 1.101271e-01 | 0.958 |
| R-HSA-3371511 | HSF1 activation | 1.141346e-01 | 0.943 |
| R-HSA-4641258 | Degradation of DVL | 1.185014e-01 | 0.926 |
| R-HSA-437239 | Recycling pathway of L1 | 1.688691e-01 | 0.772 |
| R-HSA-4791275 | Signaling by WNT in cancer | 9.298784e-02 | 1.032 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.055325e-01 | 0.977 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.129111e-02 | 1.090 |
| R-HSA-5693538 | Homology Directed Repair | 1.032326e-01 | 0.986 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.017761e-01 | 0.992 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.017761e-01 | 0.992 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.487282e-01 | 0.828 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.600794e-01 | 0.796 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.600794e-01 | 0.796 |
| R-HSA-4839744 | Signaling by APC mutants | 1.712799e-01 | 0.766 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.823317e-01 | 0.739 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.932368e-01 | 0.714 |
| R-HSA-399719 | Trafficking of AMPA receptors | 8.891014e-02 | 1.051 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.055325e-01 | 0.977 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.713387e-01 | 0.766 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.287767e-02 | 1.032 |
| R-HSA-69190 | DNA strand elongation | 9.298784e-02 | 1.032 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.583888e-01 | 0.800 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.487282e-01 | 0.828 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.229094e-01 | 0.910 |
| R-HSA-912446 | Meiotic recombination | 1.879838e-01 | 0.726 |
| R-HSA-69306 | DNA Replication | 8.195826e-02 | 1.086 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 8.347550e-02 | 1.078 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 8.855899e-02 | 1.053 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.098110e-01 | 0.959 |
| R-HSA-73886 | Chromosome Maintenance | 1.096444e-01 | 0.960 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 8.964074e-02 | 1.047 |
| R-HSA-1483152 | Hydrolysis of LPE | 1.137503e-01 | 0.944 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.250911e-01 | 0.648 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.014932e-01 | 0.696 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 9.376961e-02 | 1.028 |
| R-HSA-9664873 | Pexophagy | 1.600794e-01 | 0.796 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.017761e-01 | 0.992 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.098110e-01 | 0.959 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.912996e-01 | 0.718 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.040912e-01 | 0.690 |
| R-HSA-109581 | Apoptosis | 2.236093e-01 | 0.651 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.318896e-01 | 0.635 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 8.964074e-02 | 1.047 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.487282e-01 | 0.828 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.600794e-01 | 0.796 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.600794e-01 | 0.796 |
| R-HSA-425381 | Bicarbonate transporters | 1.712799e-01 | 0.766 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.823317e-01 | 0.739 |
| R-HSA-69091 | Polymerase switching | 1.932368e-01 | 0.714 |
| R-HSA-69109 | Leading Strand Synthesis | 1.932368e-01 | 0.714 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.368164e-01 | 0.626 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.547694e-01 | 0.810 |
| R-HSA-69236 | G1 Phase | 1.547694e-01 | 0.810 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.700015e-02 | 1.013 |
| R-HSA-69275 | G2/M Transition | 1.433655e-01 | 0.844 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 9.711889e-02 | 1.013 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.393772e-01 | 0.856 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.474764e-01 | 0.831 |
| R-HSA-68882 | Mitotic Anaphase | 2.121967e-01 | 0.673 |
| R-HSA-983189 | Kinesins | 2.318896e-01 | 0.635 |
| R-HSA-9711097 | Cellular response to starvation | 2.123942e-01 | 0.673 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.145779e-01 | 0.668 |
| R-HSA-194138 | Signaling by VEGF | 1.207158e-01 | 0.918 |
| R-HSA-68886 | M Phase | 1.765797e-01 | 0.753 |
| R-HSA-8953854 | Metabolism of RNA | 1.775738e-01 | 0.751 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.269694e-01 | 0.644 |
| R-HSA-164944 | Nef and signal transduction | 1.137503e-01 | 0.944 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.255657e-01 | 0.901 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.487282e-01 | 0.828 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.039971e-01 | 0.690 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.039971e-01 | 0.690 |
| R-HSA-69541 | Stabilization of p53 | 1.273568e-01 | 0.895 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.273568e-01 | 0.895 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.222438e-01 | 0.653 |
| R-HSA-162906 | HIV Infection | 2.388355e-01 | 0.622 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.354285e-01 | 0.628 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.014932e-01 | 0.696 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 9.711889e-02 | 1.013 |
| R-HSA-1483115 | Hydrolysis of LPC | 2.146146e-01 | 0.668 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.398480e-01 | 0.620 |
| R-HSA-9675135 | Diseases of DNA repair | 1.641442e-01 | 0.785 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.363753e-01 | 0.626 |
| R-HSA-162592 | Integration of provirus | 1.823317e-01 | 0.739 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.363625e-01 | 0.865 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.783862e-01 | 0.749 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.783862e-01 | 0.749 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.354285e-01 | 0.628 |
| R-HSA-187687 | Signalling to ERKs | 1.098110e-01 | 0.959 |
| R-HSA-9907900 | Proteasome assembly | 1.547694e-01 | 0.810 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.122599e-01 | 0.673 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 2.146146e-01 | 0.668 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.011350e-01 | 0.995 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.712799e-01 | 0.766 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.958880e-01 | 0.708 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.275812e-01 | 0.894 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.823317e-01 | 0.739 |
| R-HSA-5673000 | RAF activation | 1.055325e-01 | 0.977 |
| R-HSA-1538133 | G0 and Early G1 | 9.298784e-02 | 1.032 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.141346e-01 | 0.943 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.409173e-01 | 0.851 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.055325e-01 | 0.977 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.273568e-01 | 0.895 |
| R-HSA-166520 | Signaling by NTRKs | 1.851167e-01 | 0.733 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.912996e-01 | 0.718 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.152774e-01 | 0.667 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.547694e-01 | 0.810 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.928094e-01 | 0.715 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.152774e-01 | 0.667 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.736169e-01 | 0.760 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.591115e-01 | 0.798 |
| R-HSA-1268020 | Mitochondrial protein import | 2.417490e-01 | 0.617 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.417490e-01 | 0.617 |
| R-HSA-9707616 | Heme signaling | 2.417490e-01 | 0.617 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.456286e-01 | 0.610 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.456286e-01 | 0.610 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.456286e-01 | 0.610 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.456286e-01 | 0.610 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.466861e-01 | 0.608 |
| R-HSA-8848021 | Signaling by PTK6 | 2.466861e-01 | 0.608 |
| R-HSA-73894 | DNA Repair | 2.505387e-01 | 0.601 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.551875e-01 | 0.593 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 2.556933e-01 | 0.592 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.556933e-01 | 0.592 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.556933e-01 | 0.592 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.566011e-01 | 0.591 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.576776e-01 | 0.589 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.581044e-01 | 0.588 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.656243e-01 | 0.576 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.656243e-01 | 0.576 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.656243e-01 | 0.576 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.656243e-01 | 0.576 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.664616e-01 | 0.574 |
| R-HSA-68875 | Mitotic Prophase | 2.684618e-01 | 0.571 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.714075e-01 | 0.566 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.720685e-01 | 0.565 |
| R-HSA-3371556 | Cellular response to heat stress | 2.720685e-01 | 0.565 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.754234e-01 | 0.560 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.754234e-01 | 0.560 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.754234e-01 | 0.560 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.754234e-01 | 0.560 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.754234e-01 | 0.560 |
| R-HSA-449836 | Other interleukin signaling | 2.754234e-01 | 0.560 |
| R-HSA-168255 | Influenza Infection | 2.757394e-01 | 0.560 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.763525e-01 | 0.559 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.812956e-01 | 0.551 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.829189e-01 | 0.548 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.850923e-01 | 0.545 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.850923e-01 | 0.545 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.850923e-01 | 0.545 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.850923e-01 | 0.545 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.850923e-01 | 0.545 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.850923e-01 | 0.545 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.850923e-01 | 0.545 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.862362e-01 | 0.543 |
| R-HSA-199991 | Membrane Trafficking | 2.882820e-01 | 0.540 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.901741e-01 | 0.537 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.901741e-01 | 0.537 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.901741e-01 | 0.537 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.946328e-01 | 0.531 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.946328e-01 | 0.531 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.961061e-01 | 0.529 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.961061e-01 | 0.529 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.040466e-01 | 0.517 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.040466e-01 | 0.517 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 3.040466e-01 | 0.517 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.059561e-01 | 0.514 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.059561e-01 | 0.514 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.066448e-01 | 0.513 |
| R-HSA-5688426 | Deubiquitination | 3.100859e-01 | 0.509 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.108718e-01 | 0.507 |
| R-HSA-8964038 | LDL clearance | 3.133353e-01 | 0.504 |
| R-HSA-9843745 | Adipogenesis | 3.156560e-01 | 0.501 |
| R-HSA-68877 | Mitotic Prometaphase | 3.175624e-01 | 0.498 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.205748e-01 | 0.494 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.206811e-01 | 0.494 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.206811e-01 | 0.494 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.206811e-01 | 0.494 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 3.225005e-01 | 0.491 |
| R-HSA-9830674 | Formation of the ureteric bud | 3.225005e-01 | 0.491 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.225005e-01 | 0.491 |
| R-HSA-9659379 | Sensory processing of sound | 3.255733e-01 | 0.487 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.289278e-01 | 0.483 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.304565e-01 | 0.481 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.315441e-01 | 0.479 |
| R-HSA-429947 | Deadenylation of mRNA | 3.315441e-01 | 0.479 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.315441e-01 | 0.479 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.315441e-01 | 0.479 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.353299e-01 | 0.475 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.375390e-01 | 0.472 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.386890e-01 | 0.470 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.386890e-01 | 0.470 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.404674e-01 | 0.468 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.404674e-01 | 0.468 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.404674e-01 | 0.468 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.404674e-01 | 0.468 |
| R-HSA-3214842 | HDMs demethylate histones | 3.404674e-01 | 0.468 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.404674e-01 | 0.468 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.448285e-01 | 0.462 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.477631e-01 | 0.459 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.492722e-01 | 0.457 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.492722e-01 | 0.457 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.492722e-01 | 0.457 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.498855e-01 | 0.456 |
| R-HSA-72172 | mRNA Splicing | 3.538153e-01 | 0.451 |
| R-HSA-1500620 | Meiosis | 3.547140e-01 | 0.450 |
| R-HSA-5357801 | Programmed Cell Death | 3.568416e-01 | 0.448 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.579600e-01 | 0.446 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.579600e-01 | 0.446 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.579600e-01 | 0.446 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.579600e-01 | 0.446 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.579600e-01 | 0.446 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.665323e-01 | 0.436 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.665323e-01 | 0.436 |
| R-HSA-5620971 | Pyroptosis | 3.665323e-01 | 0.436 |
| R-HSA-622312 | Inflammasomes | 3.665323e-01 | 0.436 |
| R-HSA-70268 | Pyruvate metabolism | 3.691218e-01 | 0.433 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.691218e-01 | 0.433 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.749907e-01 | 0.426 |
| R-HSA-420092 | Glucagon-type ligand receptors | 3.749907e-01 | 0.426 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.780147e-01 | 0.422 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.786573e-01 | 0.422 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.833366e-01 | 0.416 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.833366e-01 | 0.416 |
| R-HSA-2424491 | DAP12 signaling | 3.833366e-01 | 0.416 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.833366e-01 | 0.416 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.833366e-01 | 0.416 |
| R-HSA-73884 | Base Excision Repair | 3.834027e-01 | 0.416 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.915716e-01 | 0.407 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.915716e-01 | 0.407 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.919457e-01 | 0.407 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.991301e-01 | 0.399 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.991301e-01 | 0.399 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.997002e-01 | 0.398 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.022250e-01 | 0.396 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.062916e-01 | 0.391 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.068888e-01 | 0.391 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.077147e-01 | 0.390 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.077147e-01 | 0.390 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.077147e-01 | 0.390 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.077147e-01 | 0.390 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.077147e-01 | 0.390 |
| R-HSA-159418 | Recycling of bile acids and salts | 4.077147e-01 | 0.390 |
| R-HSA-1989781 | PPARA activates gene expression | 4.098630e-01 | 0.387 |
| R-HSA-9612973 | Autophagy | 4.134281e-01 | 0.384 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.156256e-01 | 0.381 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.156256e-01 | 0.381 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.156256e-01 | 0.381 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.169864e-01 | 0.380 |
| R-HSA-162587 | HIV Life Cycle | 4.169864e-01 | 0.380 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.181476e-01 | 0.379 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.207736e-01 | 0.376 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.207736e-01 | 0.376 |
| R-HSA-195721 | Signaling by WNT | 4.234032e-01 | 0.373 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.234314e-01 | 0.373 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.234314e-01 | 0.373 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.299980e-01 | 0.367 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.311334e-01 | 0.365 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.311334e-01 | 0.365 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.344915e-01 | 0.362 |
| R-HSA-8853659 | RET signaling | 4.387329e-01 | 0.358 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.387329e-01 | 0.358 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.416893e-01 | 0.355 |
| R-HSA-4641257 | Degradation of AXIN | 4.462314e-01 | 0.350 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.462314e-01 | 0.350 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.480340e-01 | 0.349 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.480340e-01 | 0.349 |
| R-HSA-8875878 | MET promotes cell motility | 4.536302e-01 | 0.343 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.536302e-01 | 0.343 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.536302e-01 | 0.343 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.609306e-01 | 0.336 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.609306e-01 | 0.336 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.609306e-01 | 0.336 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.609306e-01 | 0.336 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.609306e-01 | 0.336 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.609306e-01 | 0.336 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.613937e-01 | 0.336 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.613937e-01 | 0.336 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.658051e-01 | 0.332 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.681338e-01 | 0.330 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.681338e-01 | 0.330 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.681338e-01 | 0.330 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.681338e-01 | 0.330 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.681338e-01 | 0.330 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.681338e-01 | 0.330 |
| R-HSA-167169 | HIV Transcription Elongation | 4.681338e-01 | 0.330 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.681338e-01 | 0.330 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.681338e-01 | 0.330 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.681338e-01 | 0.330 |
| R-HSA-5260271 | Diseases of Immune System | 4.681338e-01 | 0.330 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.681338e-01 | 0.330 |
| R-HSA-3371568 | Attenuation phase | 4.681338e-01 | 0.330 |
| R-HSA-202433 | Generation of second messenger molecules | 4.681338e-01 | 0.330 |
| R-HSA-8982491 | Glycogen metabolism | 4.681338e-01 | 0.330 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.681338e-01 | 0.330 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.752413e-01 | 0.323 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.752413e-01 | 0.323 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.752413e-01 | 0.323 |
| R-HSA-9694548 | Maturation of spike protein | 4.752413e-01 | 0.323 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.752413e-01 | 0.323 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.788681e-01 | 0.320 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.789106e-01 | 0.320 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.822542e-01 | 0.317 |
| R-HSA-112316 | Neuronal System | 4.841389e-01 | 0.315 |
| R-HSA-165159 | MTOR signalling | 4.891738e-01 | 0.311 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.960770e-01 | 0.304 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.027381e-01 | 0.299 |
| R-HSA-373752 | Netrin-1 signaling | 5.027381e-01 | 0.299 |
| R-HSA-190828 | Gap junction trafficking | 5.027381e-01 | 0.299 |
| R-HSA-2172127 | DAP12 interactions | 5.027381e-01 | 0.299 |
| R-HSA-5683826 | Surfactant metabolism | 5.027381e-01 | 0.299 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.075656e-01 | 0.295 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.093852e-01 | 0.293 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.093852e-01 | 0.293 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.093852e-01 | 0.293 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.098083e-01 | 0.293 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.159438e-01 | 0.287 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.159438e-01 | 0.287 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.159438e-01 | 0.287 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.159438e-01 | 0.287 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.159438e-01 | 0.287 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.170250e-01 | 0.286 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 5.224152e-01 | 0.282 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.224152e-01 | 0.282 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.288004e-01 | 0.277 |
| R-HSA-157858 | Gap junction trafficking and regulation | 5.351007e-01 | 0.272 |
| R-HSA-9748787 | Azathioprine ADME | 5.413171e-01 | 0.267 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.474508e-01 | 0.262 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.477560e-01 | 0.261 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.493242e-01 | 0.260 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.535028e-01 | 0.257 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.535028e-01 | 0.257 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.535028e-01 | 0.257 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.578537e-01 | 0.253 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.594742e-01 | 0.252 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.594742e-01 | 0.252 |
| R-HSA-72766 | Translation | 5.624561e-01 | 0.250 |
| R-HSA-72649 | Translation initiation complex formation | 5.653662e-01 | 0.248 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.653662e-01 | 0.248 |
| R-HSA-114608 | Platelet degranulation | 5.687322e-01 | 0.245 |
| R-HSA-9753281 | Paracetamol ADME | 5.711797e-01 | 0.243 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.733571e-01 | 0.242 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.769158e-01 | 0.239 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.769158e-01 | 0.239 |
| R-HSA-177929 | Signaling by EGFR | 5.769158e-01 | 0.239 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.825755e-01 | 0.235 |
| R-HSA-5621480 | Dectin-2 family | 5.825755e-01 | 0.235 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.825755e-01 | 0.235 |
| R-HSA-1474165 | Reproduction | 5.838211e-01 | 0.234 |
| R-HSA-5576891 | Cardiac conduction | 5.875324e-01 | 0.231 |
| R-HSA-74160 | Gene expression (Transcription) | 5.878246e-01 | 0.231 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.881599e-01 | 0.231 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.936699e-01 | 0.226 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.936699e-01 | 0.226 |
| R-HSA-191859 | snRNP Assembly | 5.936699e-01 | 0.226 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.948815e-01 | 0.226 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.991065e-01 | 0.222 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.044707e-01 | 0.219 |
| R-HSA-211976 | Endogenous sterols | 6.044707e-01 | 0.219 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.097635e-01 | 0.215 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.097635e-01 | 0.215 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.097635e-01 | 0.215 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.097635e-01 | 0.215 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 6.149857e-01 | 0.211 |
| R-HSA-6807070 | PTEN Regulation | 6.198329e-01 | 0.208 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.201384e-01 | 0.208 |
| R-HSA-1632852 | Macroautophagy | 6.267422e-01 | 0.203 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.302388e-01 | 0.200 |
| R-HSA-913531 | Interferon Signaling | 6.326145e-01 | 0.199 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.335541e-01 | 0.198 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.335541e-01 | 0.198 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.351882e-01 | 0.197 |
| R-HSA-913709 | O-linked glycosylation of mucins | 6.400718e-01 | 0.194 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.400718e-01 | 0.194 |
| R-HSA-167172 | Transcription of the HIV genome | 6.400718e-01 | 0.194 |
| R-HSA-5218859 | Regulated Necrosis | 6.400718e-01 | 0.194 |
| R-HSA-9824439 | Bacterial Infection Pathways | 6.475458e-01 | 0.189 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.496445e-01 | 0.187 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 6.501603e-01 | 0.187 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.543354e-01 | 0.184 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 6.543354e-01 | 0.184 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.543354e-01 | 0.184 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.589637e-01 | 0.181 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.589637e-01 | 0.181 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.589637e-01 | 0.181 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 6.589637e-01 | 0.181 |
| R-HSA-1500931 | Cell-Cell communication | 6.615571e-01 | 0.179 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.635304e-01 | 0.178 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.680362e-01 | 0.175 |
| R-HSA-9609507 | Protein localization | 6.692959e-01 | 0.174 |
| R-HSA-73887 | Death Receptor Signaling | 6.724020e-01 | 0.172 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.724819e-01 | 0.172 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.772477e-01 | 0.169 |
| R-HSA-1280218 | Adaptive Immune System | 6.790597e-01 | 0.168 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.811964e-01 | 0.167 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 6.896800e-01 | 0.161 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.896800e-01 | 0.161 |
| R-HSA-6806834 | Signaling by MET | 6.938372e-01 | 0.159 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.938372e-01 | 0.159 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.938372e-01 | 0.159 |
| R-HSA-9833482 | PKR-mediated signaling | 6.938372e-01 | 0.159 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.019860e-01 | 0.154 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.025829e-01 | 0.153 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.059790e-01 | 0.151 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 7.099188e-01 | 0.149 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.099188e-01 | 0.149 |
| R-HSA-5619102 | SLC transporter disorders | 7.106649e-01 | 0.148 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.176415e-01 | 0.144 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.214257e-01 | 0.142 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.288434e-01 | 0.137 |
| R-HSA-9663891 | Selective autophagy | 7.288434e-01 | 0.137 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.288434e-01 | 0.137 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.330410e-01 | 0.135 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.349195e-01 | 0.134 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.360644e-01 | 0.133 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.360644e-01 | 0.133 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.465386e-01 | 0.127 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.465386e-01 | 0.127 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.499373e-01 | 0.125 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.562121e-01 | 0.121 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.565990e-01 | 0.121 |
| R-HSA-449147 | Signaling by Interleukins | 7.665312e-01 | 0.115 |
| R-HSA-5617833 | Cilium Assembly | 7.715070e-01 | 0.113 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.724907e-01 | 0.112 |
| R-HSA-5663205 | Infectious disease | 7.741743e-01 | 0.111 |
| R-HSA-70171 | Glycolysis | 7.755428e-01 | 0.110 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.755428e-01 | 0.110 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.785542e-01 | 0.109 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.925682e-01 | 0.101 |
| R-HSA-212436 | Generic Transcription Pathway | 7.925931e-01 | 0.101 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.975448e-01 | 0.098 |
| R-HSA-211000 | Gene Silencing by RNA | 7.985374e-01 | 0.098 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.995921e-01 | 0.097 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.030014e-01 | 0.095 |
| R-HSA-5419276 | Mitochondrial translation termination | 8.039097e-01 | 0.095 |
| R-HSA-202403 | TCR signaling | 8.065422e-01 | 0.093 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.065422e-01 | 0.093 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.117020e-01 | 0.091 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.216143e-01 | 0.085 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.240101e-01 | 0.084 |
| R-HSA-70326 | Glucose metabolism | 8.287061e-01 | 0.082 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.420587e-01 | 0.075 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.420587e-01 | 0.075 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.467576e-01 | 0.072 |
| R-HSA-1643685 | Disease | 8.490030e-01 | 0.071 |
| R-HSA-8956319 | Nucleotide catabolism | 8.563325e-01 | 0.067 |
| R-HSA-168256 | Immune System | 8.589377e-01 | 0.066 |
| R-HSA-15869 | Metabolism of nucleotides | 8.591093e-01 | 0.066 |
| R-HSA-9717189 | Sensory perception of taste | 8.620497e-01 | 0.064 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.639046e-01 | 0.064 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.643883e-01 | 0.063 |
| R-HSA-168249 | Innate Immune System | 8.737322e-01 | 0.059 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.739910e-01 | 0.058 |
| R-HSA-5173105 | O-linked glycosylation | 8.745243e-01 | 0.058 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.745243e-01 | 0.058 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.746142e-01 | 0.058 |
| R-HSA-5368287 | Mitochondrial translation | 8.762122e-01 | 0.057 |
| R-HSA-421270 | Cell-cell junction organization | 8.798533e-01 | 0.056 |
| R-HSA-9679506 | SARS-CoV Infections | 8.879879e-01 | 0.052 |
| R-HSA-9610379 | HCMV Late Events | 9.056022e-01 | 0.043 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.068737e-01 | 0.042 |
| R-HSA-9824446 | Viral Infection Pathways | 9.079644e-01 | 0.042 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.102616e-01 | 0.041 |
| R-HSA-446728 | Cell junction organization | 9.102616e-01 | 0.041 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.141030e-01 | 0.039 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.175769e-01 | 0.037 |
| R-HSA-72306 | tRNA processing | 9.219320e-01 | 0.035 |
| R-HSA-418555 | G alpha (s) signalling events | 9.229845e-01 | 0.035 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.229845e-01 | 0.035 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.250473e-01 | 0.034 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.250473e-01 | 0.034 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.255522e-01 | 0.034 |
| R-HSA-1483257 | Phospholipid metabolism | 9.255522e-01 | 0.034 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.326095e-01 | 0.030 |
| R-HSA-3781865 | Diseases of glycosylation | 9.354477e-01 | 0.029 |
| R-HSA-392499 | Metabolism of proteins | 9.422787e-01 | 0.026 |
| R-HSA-9609690 | HCMV Early Events | 9.451614e-01 | 0.024 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.451614e-01 | 0.024 |
| R-HSA-597592 | Post-translational protein modification | 9.471510e-01 | 0.024 |
| R-HSA-1474244 | Extracellular matrix organization | 9.502203e-01 | 0.022 |
| R-HSA-162582 | Signal Transduction | 9.522155e-01 | 0.021 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.560560e-01 | 0.020 |
| R-HSA-9748784 | Drug ADME | 9.598959e-01 | 0.018 |
| R-HSA-418990 | Adherens junctions interactions | 9.598959e-01 | 0.018 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.659429e-01 | 0.015 |
| R-HSA-9609646 | HCMV Infection | 9.740710e-01 | 0.011 |
| R-HSA-416476 | G alpha (q) signalling events | 9.785808e-01 | 0.009 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.797195e-01 | 0.009 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.828192e-01 | 0.008 |
| R-HSA-109582 | Hemostasis | 9.846282e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.883882e-01 | 0.005 |
| R-HSA-6798695 | Neutrophil degranulation | 9.886624e-01 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 9.905741e-01 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.945560e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.948920e-01 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.965897e-01 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 9.977447e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.986675e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.995011e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.997615e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.998894e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999928e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999956e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.864 | 0.086 | 2 | 0.903 |
CDC7 |
0.857 | 0.061 | 1 | 0.889 |
GCN2 |
0.853 | -0.049 | 2 | 0.848 |
PRPK |
0.852 | -0.060 | -1 | 0.836 |
DSTYK |
0.851 | 0.055 | 2 | 0.878 |
MOS |
0.850 | 0.030 | 1 | 0.915 |
CAMK1B |
0.849 | -0.013 | -3 | 0.769 |
ERK5 |
0.849 | 0.082 | 1 | 0.848 |
NLK |
0.849 | 0.043 | 1 | 0.839 |
TGFBR2 |
0.847 | 0.025 | -2 | 0.763 |
BMPR2 |
0.846 | -0.045 | -2 | 0.828 |
PDHK4 |
0.846 | -0.185 | 1 | 0.850 |
CAMK2G |
0.846 | -0.024 | 2 | 0.847 |
NEK7 |
0.846 | 0.004 | -3 | 0.768 |
WNK1 |
0.846 | 0.059 | -2 | 0.831 |
ULK2 |
0.845 | -0.109 | 2 | 0.846 |
RIPK3 |
0.845 | 0.016 | 3 | 0.831 |
MARK4 |
0.845 | 0.054 | 4 | 0.883 |
CDKL1 |
0.844 | 0.012 | -3 | 0.718 |
TBK1 |
0.844 | -0.082 | 1 | 0.704 |
RAF1 |
0.844 | -0.130 | 1 | 0.836 |
SKMLCK |
0.844 | 0.044 | -2 | 0.791 |
NEK6 |
0.844 | 0.022 | -2 | 0.841 |
PIM3 |
0.843 | -0.024 | -3 | 0.729 |
IKKB |
0.842 | -0.149 | -2 | 0.708 |
TSSK2 |
0.842 | 0.066 | -5 | 0.886 |
CAMLCK |
0.842 | -0.000 | -2 | 0.773 |
CDKL5 |
0.842 | 0.031 | -3 | 0.709 |
PDHK1 |
0.841 | -0.157 | 1 | 0.829 |
CLK3 |
0.841 | 0.063 | 1 | 0.853 |
RSK2 |
0.841 | 0.012 | -3 | 0.689 |
NUAK2 |
0.841 | 0.002 | -3 | 0.730 |
MTOR |
0.840 | -0.147 | 1 | 0.788 |
KIS |
0.840 | 0.048 | 1 | 0.714 |
P90RSK |
0.840 | 0.000 | -3 | 0.699 |
ALK4 |
0.840 | 0.114 | -2 | 0.804 |
DAPK2 |
0.840 | -0.006 | -3 | 0.774 |
AMPKA1 |
0.839 | 0.015 | -3 | 0.734 |
WNK3 |
0.839 | -0.082 | 1 | 0.814 |
ATR |
0.839 | -0.086 | 1 | 0.818 |
IKKE |
0.839 | -0.128 | 1 | 0.701 |
NDR2 |
0.839 | -0.063 | -3 | 0.722 |
GRK5 |
0.839 | -0.102 | -3 | 0.737 |
TSSK1 |
0.839 | 0.062 | -3 | 0.755 |
BMPR1B |
0.838 | 0.163 | 1 | 0.851 |
NIK |
0.838 | -0.078 | -3 | 0.777 |
GRK6 |
0.838 | 0.005 | 1 | 0.854 |
PKN3 |
0.837 | -0.040 | -3 | 0.727 |
TGFBR1 |
0.837 | 0.105 | -2 | 0.777 |
NIM1 |
0.837 | -0.021 | 3 | 0.805 |
MAPKAPK3 |
0.837 | -0.017 | -3 | 0.678 |
MLK1 |
0.836 | -0.070 | 2 | 0.824 |
ULK1 |
0.836 | -0.140 | -3 | 0.734 |
RSK3 |
0.836 | -0.021 | -3 | 0.694 |
HUNK |
0.836 | -0.120 | 2 | 0.874 |
SRPK1 |
0.836 | 0.033 | -3 | 0.670 |
PRKD1 |
0.836 | -0.043 | -3 | 0.719 |
NEK9 |
0.835 | -0.048 | 2 | 0.863 |
HIPK4 |
0.835 | 0.002 | 1 | 0.850 |
ANKRD3 |
0.834 | -0.021 | 1 | 0.851 |
NDR1 |
0.834 | -0.072 | -3 | 0.721 |
CHAK2 |
0.834 | -0.050 | -1 | 0.823 |
PLK1 |
0.834 | 0.003 | -2 | 0.778 |
RIPK1 |
0.833 | -0.087 | 1 | 0.831 |
ATM |
0.833 | -0.004 | 1 | 0.757 |
CAMK2D |
0.833 | -0.057 | -3 | 0.747 |
PRKD2 |
0.833 | -0.020 | -3 | 0.673 |
MELK |
0.832 | 0.002 | -3 | 0.702 |
IRE1 |
0.832 | -0.028 | 1 | 0.835 |
ALK2 |
0.831 | 0.131 | -2 | 0.784 |
MASTL |
0.831 | -0.211 | -2 | 0.776 |
AMPKA2 |
0.831 | -0.011 | -3 | 0.703 |
GRK4 |
0.831 | -0.085 | -2 | 0.768 |
PIM1 |
0.831 | -0.003 | -3 | 0.673 |
PKN2 |
0.831 | -0.068 | -3 | 0.713 |
NUAK1 |
0.830 | -0.007 | -3 | 0.700 |
MAPKAPK2 |
0.830 | -0.005 | -3 | 0.632 |
PKCD |
0.830 | -0.026 | 2 | 0.813 |
ICK |
0.830 | -0.043 | -3 | 0.743 |
BCKDK |
0.830 | -0.154 | -1 | 0.790 |
MST4 |
0.830 | -0.068 | 2 | 0.819 |
LATS2 |
0.829 | -0.059 | -5 | 0.762 |
QIK |
0.829 | -0.032 | -3 | 0.740 |
MARK2 |
0.829 | 0.064 | 4 | 0.815 |
IRE2 |
0.829 | -0.000 | 2 | 0.818 |
P70S6KB |
0.829 | -0.052 | -3 | 0.705 |
IKKA |
0.829 | -0.099 | -2 | 0.699 |
ACVR2B |
0.829 | 0.079 | -2 | 0.757 |
ACVR2A |
0.829 | 0.065 | -2 | 0.746 |
FAM20C |
0.829 | 0.002 | 2 | 0.552 |
TTBK2 |
0.829 | -0.124 | 2 | 0.770 |
SMG1 |
0.828 | 0.039 | 1 | 0.763 |
CAMK4 |
0.828 | -0.094 | -3 | 0.709 |
PKR |
0.828 | 0.026 | 1 | 0.867 |
GRK1 |
0.828 | -0.041 | -2 | 0.721 |
QSK |
0.828 | 0.013 | 4 | 0.860 |
PLK3 |
0.827 | 0.003 | 2 | 0.819 |
PKACG |
0.827 | -0.067 | -2 | 0.678 |
BMPR1A |
0.826 | 0.166 | 1 | 0.836 |
SRPK2 |
0.826 | 0.011 | -3 | 0.606 |
MARK3 |
0.826 | 0.042 | 4 | 0.844 |
PRKD3 |
0.826 | -0.016 | -3 | 0.667 |
CAMK2B |
0.826 | -0.003 | 2 | 0.796 |
NEK2 |
0.826 | -0.024 | 2 | 0.837 |
MYLK4 |
0.825 | -0.016 | -2 | 0.688 |
MLK3 |
0.825 | -0.035 | 2 | 0.750 |
CDK8 |
0.825 | -0.017 | 1 | 0.683 |
VRK2 |
0.825 | -0.029 | 1 | 0.889 |
MNK2 |
0.825 | -0.047 | -2 | 0.726 |
CLK1 |
0.825 | 0.041 | -3 | 0.664 |
MLK2 |
0.825 | -0.141 | 2 | 0.837 |
DYRK2 |
0.824 | 0.016 | 1 | 0.758 |
PAK3 |
0.824 | -0.093 | -2 | 0.688 |
CLK4 |
0.824 | 0.018 | -3 | 0.679 |
PAK1 |
0.824 | -0.071 | -2 | 0.685 |
BRSK2 |
0.824 | -0.030 | -3 | 0.722 |
SIK |
0.823 | -0.018 | -3 | 0.671 |
MSK2 |
0.823 | -0.064 | -3 | 0.657 |
PAK6 |
0.823 | -0.029 | -2 | 0.626 |
BRSK1 |
0.823 | -0.030 | -3 | 0.700 |
AURC |
0.822 | -0.037 | -2 | 0.579 |
PERK |
0.822 | -0.027 | -2 | 0.790 |
MEK1 |
0.822 | -0.140 | 2 | 0.869 |
CHK1 |
0.822 | -0.045 | -3 | 0.722 |
DLK |
0.822 | -0.252 | 1 | 0.835 |
SRPK3 |
0.821 | -0.014 | -3 | 0.648 |
AURB |
0.821 | -0.029 | -2 | 0.580 |
CDK7 |
0.821 | -0.021 | 1 | 0.693 |
JNK2 |
0.821 | 0.054 | 1 | 0.629 |
PKG2 |
0.820 | -0.021 | -2 | 0.605 |
P38A |
0.820 | 0.027 | 1 | 0.735 |
MARK1 |
0.820 | -0.006 | 4 | 0.857 |
TLK2 |
0.820 | -0.033 | 1 | 0.805 |
SNRK |
0.820 | -0.121 | 2 | 0.775 |
JNK3 |
0.820 | 0.039 | 1 | 0.671 |
PAK2 |
0.819 | -0.088 | -2 | 0.677 |
GRK7 |
0.819 | 0.020 | 1 | 0.793 |
CAMK1G |
0.819 | -0.022 | -3 | 0.679 |
PRP4 |
0.819 | 0.040 | -3 | 0.675 |
WNK4 |
0.819 | 0.021 | -2 | 0.847 |
HRI |
0.819 | -0.087 | -2 | 0.797 |
LATS1 |
0.818 | -0.053 | -3 | 0.750 |
MLK4 |
0.818 | -0.057 | 2 | 0.747 |
CDK2 |
0.818 | 0.026 | 1 | 0.731 |
IRAK4 |
0.818 | -0.003 | 1 | 0.826 |
RSK4 |
0.818 | -0.022 | -3 | 0.652 |
CHAK1 |
0.818 | -0.104 | 2 | 0.816 |
MAPKAPK5 |
0.818 | -0.089 | -3 | 0.644 |
YSK4 |
0.817 | -0.132 | 1 | 0.767 |
CAMK2A |
0.817 | -0.045 | 2 | 0.809 |
PLK4 |
0.817 | -0.085 | 2 | 0.739 |
MSK1 |
0.817 | -0.041 | -3 | 0.654 |
PHKG1 |
0.816 | -0.096 | -3 | 0.716 |
CDK19 |
0.816 | -0.028 | 1 | 0.642 |
BRAF |
0.816 | -0.056 | -4 | 0.791 |
DCAMKL1 |
0.816 | -0.021 | -3 | 0.681 |
SGK3 |
0.816 | -0.027 | -3 | 0.655 |
MNK1 |
0.816 | -0.071 | -2 | 0.729 |
PKCB |
0.815 | -0.052 | 2 | 0.747 |
P38B |
0.815 | 0.031 | 1 | 0.663 |
PKCZ |
0.815 | -0.068 | 2 | 0.813 |
NEK5 |
0.815 | 0.012 | 1 | 0.832 |
CDK13 |
0.815 | -0.012 | 1 | 0.665 |
ERK2 |
0.815 | 0.003 | 1 | 0.691 |
PINK1 |
0.815 | -0.111 | 1 | 0.856 |
GRK2 |
0.814 | -0.073 | -2 | 0.661 |
PKCH |
0.814 | -0.074 | 2 | 0.754 |
DRAK1 |
0.814 | -0.070 | 1 | 0.754 |
PIM2 |
0.814 | -0.022 | -3 | 0.664 |
CDK1 |
0.814 | 0.024 | 1 | 0.653 |
CDK5 |
0.814 | 0.009 | 1 | 0.714 |
DCAMKL2 |
0.813 | -0.032 | -3 | 0.717 |
TLK1 |
0.813 | -0.063 | -2 | 0.777 |
AURA |
0.813 | -0.046 | -2 | 0.546 |
DYRK1A |
0.813 | -0.000 | 1 | 0.763 |
ERK1 |
0.813 | 0.007 | 1 | 0.648 |
SMMLCK |
0.813 | -0.037 | -3 | 0.726 |
PKCA |
0.813 | -0.071 | 2 | 0.744 |
AKT2 |
0.812 | -0.027 | -3 | 0.613 |
PKCG |
0.812 | -0.098 | 2 | 0.760 |
SSTK |
0.812 | -0.008 | 4 | 0.845 |
DNAPK |
0.812 | -0.056 | 1 | 0.652 |
CDK18 |
0.812 | 0.003 | 1 | 0.625 |
PKACB |
0.811 | -0.039 | -2 | 0.605 |
P38G |
0.811 | 0.028 | 1 | 0.567 |
TTBK1 |
0.811 | -0.092 | 2 | 0.703 |
CAMK1D |
0.811 | -0.006 | -3 | 0.629 |
MEKK2 |
0.810 | -0.073 | 2 | 0.841 |
IRAK1 |
0.810 | -0.129 | -1 | 0.793 |
MEKK3 |
0.809 | -0.159 | 1 | 0.804 |
CLK2 |
0.809 | 0.043 | -3 | 0.667 |
HIPK1 |
0.809 | 0.001 | 1 | 0.769 |
HIPK3 |
0.809 | -0.010 | 1 | 0.758 |
MEKK1 |
0.809 | -0.134 | 1 | 0.803 |
ZAK |
0.808 | -0.126 | 1 | 0.777 |
CDK17 |
0.808 | -0.002 | 1 | 0.570 |
MEK5 |
0.808 | -0.245 | 2 | 0.855 |
P38D |
0.807 | 0.049 | 1 | 0.577 |
P70S6K |
0.807 | -0.064 | -3 | 0.630 |
DYRK3 |
0.807 | 0.007 | 1 | 0.784 |
CDK12 |
0.806 | -0.018 | 1 | 0.636 |
DYRK1B |
0.806 | 0.009 | 1 | 0.692 |
CDK9 |
0.805 | -0.046 | 1 | 0.671 |
HIPK2 |
0.805 | 0.003 | 1 | 0.668 |
PRKX |
0.805 | -0.016 | -3 | 0.576 |
CDK14 |
0.805 | 0.007 | 1 | 0.661 |
CDK3 |
0.805 | 0.052 | 1 | 0.592 |
PHKG2 |
0.805 | -0.093 | -3 | 0.693 |
DYRK4 |
0.804 | 0.008 | 1 | 0.668 |
PKACA |
0.804 | -0.031 | -2 | 0.549 |
NEK8 |
0.804 | -0.091 | 2 | 0.854 |
GSK3B |
0.804 | -0.027 | 4 | 0.436 |
CK2A2 |
0.803 | 0.070 | 1 | 0.746 |
MPSK1 |
0.803 | -0.055 | 1 | 0.825 |
AKT1 |
0.803 | -0.033 | -3 | 0.617 |
PKCT |
0.802 | -0.080 | 2 | 0.763 |
DAPK3 |
0.802 | -0.014 | -3 | 0.700 |
ERK7 |
0.802 | 0.029 | 2 | 0.562 |
CAMKK1 |
0.802 | -0.139 | -2 | 0.717 |
VRK1 |
0.802 | 0.100 | 2 | 0.914 |
CK1E |
0.802 | -0.117 | -3 | 0.406 |
GAK |
0.802 | -0.024 | 1 | 0.854 |
GRK3 |
0.801 | -0.071 | -2 | 0.624 |
PAK5 |
0.801 | -0.073 | -2 | 0.551 |
PKCI |
0.801 | -0.066 | 2 | 0.775 |
PLK2 |
0.801 | 0.023 | -3 | 0.775 |
MST3 |
0.800 | -0.102 | 2 | 0.830 |
GSK3A |
0.800 | -0.005 | 4 | 0.449 |
CHK2 |
0.800 | -0.015 | -3 | 0.563 |
PASK |
0.800 | -0.079 | -3 | 0.737 |
CDK16 |
0.799 | 0.016 | 1 | 0.589 |
NEK4 |
0.799 | -0.085 | 1 | 0.781 |
LKB1 |
0.799 | -0.101 | -3 | 0.756 |
PKN1 |
0.799 | -0.042 | -3 | 0.644 |
PAK4 |
0.799 | -0.066 | -2 | 0.551 |
CAMK1A |
0.798 | -0.008 | -3 | 0.576 |
TAO2 |
0.798 | -0.115 | 2 | 0.864 |
PDK1 |
0.797 | -0.107 | 1 | 0.790 |
EEF2K |
0.797 | -0.026 | 3 | 0.836 |
TAO3 |
0.797 | -0.132 | 1 | 0.794 |
JNK1 |
0.797 | 0.017 | 1 | 0.620 |
CK1G1 |
0.796 | -0.129 | -3 | 0.423 |
DAPK1 |
0.796 | -0.033 | -3 | 0.684 |
NEK1 |
0.795 | -0.045 | 1 | 0.807 |
CK1D |
0.795 | -0.111 | -3 | 0.353 |
CAMKK2 |
0.794 | -0.177 | -2 | 0.701 |
NEK11 |
0.793 | -0.225 | 1 | 0.768 |
MST2 |
0.793 | -0.112 | 1 | 0.795 |
RIPK2 |
0.793 | -0.163 | 1 | 0.728 |
MRCKB |
0.793 | -0.024 | -3 | 0.646 |
LRRK2 |
0.793 | -0.133 | 2 | 0.880 |
PKCE |
0.793 | -0.053 | 2 | 0.742 |
MRCKA |
0.793 | -0.028 | -3 | 0.663 |
CK2A1 |
0.792 | 0.044 | 1 | 0.720 |
TAK1 |
0.792 | -0.110 | 1 | 0.814 |
SGK1 |
0.792 | -0.016 | -3 | 0.536 |
CK1A2 |
0.791 | -0.122 | -3 | 0.353 |
MEKK6 |
0.791 | -0.150 | 1 | 0.803 |
MEK2 |
0.791 | -0.142 | 2 | 0.853 |
CDK6 |
0.790 | -0.003 | 1 | 0.641 |
AKT3 |
0.790 | -0.031 | -3 | 0.550 |
STK33 |
0.789 | -0.121 | 2 | 0.690 |
HGK |
0.789 | -0.115 | 3 | 0.854 |
TTK |
0.789 | 0.057 | -2 | 0.779 |
CDK10 |
0.789 | -0.030 | 1 | 0.648 |
MINK |
0.789 | -0.114 | 1 | 0.774 |
MAP3K15 |
0.788 | -0.162 | 1 | 0.762 |
BUB1 |
0.788 | 0.014 | -5 | 0.808 |
ROCK2 |
0.788 | -0.025 | -3 | 0.676 |
TNIK |
0.787 | -0.089 | 3 | 0.853 |
PKG1 |
0.787 | -0.044 | -2 | 0.517 |
MOK |
0.787 | 0.002 | 1 | 0.814 |
NEK3 |
0.787 | -0.075 | 1 | 0.761 |
SBK |
0.786 | -0.028 | -3 | 0.515 |
GCK |
0.786 | -0.149 | 1 | 0.779 |
PBK |
0.786 | -0.037 | 1 | 0.780 |
CDK4 |
0.785 | -0.022 | 1 | 0.624 |
LOK |
0.785 | -0.132 | -2 | 0.707 |
MAK |
0.785 | -0.005 | -2 | 0.621 |
MST1 |
0.784 | -0.147 | 1 | 0.777 |
DMPK1 |
0.784 | -0.003 | -3 | 0.658 |
PDHK3_TYR |
0.782 | 0.041 | 4 | 0.872 |
HPK1 |
0.781 | -0.156 | 1 | 0.757 |
YSK1 |
0.780 | -0.131 | 2 | 0.818 |
ROCK1 |
0.777 | -0.035 | -3 | 0.652 |
KHS1 |
0.777 | -0.121 | 1 | 0.758 |
SLK |
0.776 | -0.164 | -2 | 0.654 |
BIKE |
0.775 | -0.007 | 1 | 0.728 |
KHS2 |
0.774 | -0.096 | 1 | 0.764 |
YES1 |
0.774 | 0.149 | -1 | 0.902 |
TXK |
0.774 | 0.214 | 1 | 0.853 |
EPHB4 |
0.773 | 0.116 | -1 | 0.863 |
EPHA6 |
0.773 | 0.066 | -1 | 0.846 |
TESK1_TYR |
0.773 | -0.138 | 3 | 0.879 |
TYRO3 |
0.773 | 0.081 | 3 | 0.827 |
PKMYT1_TYR |
0.773 | -0.082 | 3 | 0.869 |
CRIK |
0.771 | -0.051 | -3 | 0.614 |
MAP2K7_TYR |
0.771 | -0.186 | 2 | 0.892 |
MYO3B |
0.771 | -0.060 | 2 | 0.829 |
PDHK4_TYR |
0.771 | -0.067 | 2 | 0.896 |
MAP2K4_TYR |
0.770 | -0.179 | -1 | 0.849 |
BLK |
0.770 | 0.203 | -1 | 0.872 |
SRMS |
0.770 | 0.139 | 1 | 0.872 |
HCK |
0.770 | 0.131 | -1 | 0.872 |
TEC |
0.769 | 0.196 | -1 | 0.857 |
OSR1 |
0.769 | -0.122 | 2 | 0.820 |
ALPHAK3 |
0.769 | -0.045 | -1 | 0.736 |
MAP2K6_TYR |
0.768 | -0.144 | -1 | 0.837 |
HASPIN |
0.768 | -0.066 | -1 | 0.659 |
ABL2 |
0.768 | 0.079 | -1 | 0.852 |
TNK2 |
0.768 | 0.093 | 3 | 0.815 |
MST1R |
0.768 | -0.012 | 3 | 0.845 |
BMPR2_TYR |
0.768 | -0.090 | -1 | 0.804 |
PINK1_TYR |
0.768 | -0.205 | 1 | 0.860 |
EPHB1 |
0.768 | 0.123 | 1 | 0.865 |
ROS1 |
0.768 | 0.010 | 3 | 0.812 |
CSF1R |
0.768 | 0.030 | 3 | 0.839 |
EPHB2 |
0.767 | 0.145 | -1 | 0.852 |
ABL1 |
0.767 | 0.087 | -1 | 0.858 |
RET |
0.767 | -0.056 | 1 | 0.812 |
PDHK1_TYR |
0.767 | -0.120 | -1 | 0.859 |
ASK1 |
0.767 | -0.185 | 1 | 0.748 |
LCK |
0.766 | 0.136 | -1 | 0.858 |
ITK |
0.766 | 0.106 | -1 | 0.856 |
MERTK |
0.766 | 0.148 | 3 | 0.821 |
LIMK2_TYR |
0.766 | -0.098 | -3 | 0.784 |
EPHB3 |
0.765 | 0.109 | -1 | 0.863 |
DDR1 |
0.765 | -0.063 | 4 | 0.807 |
AXL |
0.765 | 0.099 | 3 | 0.829 |
FER |
0.765 | 0.016 | 1 | 0.886 |
MYO3A |
0.765 | -0.125 | 1 | 0.782 |
TAO1 |
0.765 | -0.131 | 1 | 0.719 |
EPHA4 |
0.764 | 0.055 | 2 | 0.807 |
FGR |
0.764 | -0.000 | 1 | 0.859 |
TYK2 |
0.763 | -0.125 | 1 | 0.807 |
LIMK1_TYR |
0.763 | -0.166 | 2 | 0.887 |
JAK2 |
0.763 | -0.079 | 1 | 0.797 |
BTK |
0.762 | 0.085 | -1 | 0.858 |
TEK |
0.761 | 0.020 | 3 | 0.785 |
YANK3 |
0.761 | -0.099 | 2 | 0.460 |
PTK2B |
0.760 | 0.124 | -1 | 0.879 |
INSRR |
0.760 | -0.026 | 3 | 0.799 |
EPHA7 |
0.759 | 0.092 | 2 | 0.822 |
LTK |
0.759 | 0.038 | 3 | 0.798 |
FYN |
0.759 | 0.107 | -1 | 0.822 |
PDGFRB |
0.759 | -0.059 | 3 | 0.843 |
LYN |
0.758 | 0.101 | 3 | 0.779 |
BMX |
0.758 | 0.059 | -1 | 0.773 |
EPHA1 |
0.758 | 0.097 | 3 | 0.811 |
FRK |
0.758 | 0.088 | -1 | 0.897 |
AAK1 |
0.757 | 0.014 | 1 | 0.626 |
FGFR2 |
0.757 | -0.075 | 3 | 0.844 |
TNK1 |
0.757 | -0.032 | 3 | 0.807 |
ALK |
0.756 | -0.002 | 3 | 0.772 |
STLK3 |
0.756 | -0.188 | 1 | 0.744 |
KIT |
0.756 | -0.058 | 3 | 0.839 |
JAK3 |
0.756 | -0.106 | 1 | 0.796 |
FGFR1 |
0.756 | -0.057 | 3 | 0.819 |
FLT3 |
0.754 | -0.075 | 3 | 0.824 |
KDR |
0.754 | -0.054 | 3 | 0.828 |
TNNI3K_TYR |
0.754 | -0.030 | 1 | 0.831 |
PTK6 |
0.753 | -0.030 | -1 | 0.794 |
CK1A |
0.752 | -0.148 | -3 | 0.270 |
JAK1 |
0.752 | -0.037 | 1 | 0.733 |
WEE1_TYR |
0.752 | -0.027 | -1 | 0.762 |
DDR2 |
0.752 | 0.024 | 3 | 0.807 |
SRC |
0.751 | 0.070 | -1 | 0.850 |
EPHA3 |
0.751 | -0.026 | 2 | 0.798 |
PDGFRA |
0.751 | -0.120 | 3 | 0.843 |
NTRK1 |
0.750 | -0.092 | -1 | 0.815 |
EPHA5 |
0.749 | 0.054 | 2 | 0.802 |
MET |
0.749 | -0.069 | 3 | 0.824 |
NTRK2 |
0.749 | -0.066 | 3 | 0.810 |
NEK10_TYR |
0.747 | -0.133 | 1 | 0.681 |
EPHA8 |
0.747 | 0.030 | -1 | 0.820 |
ERBB2 |
0.746 | -0.102 | 1 | 0.766 |
FGFR3 |
0.745 | -0.092 | 3 | 0.826 |
INSR |
0.745 | -0.087 | 3 | 0.775 |
MATK |
0.743 | -0.081 | -1 | 0.753 |
FLT4 |
0.742 | -0.133 | 3 | 0.819 |
NTRK3 |
0.742 | -0.086 | -1 | 0.764 |
FLT1 |
0.740 | -0.136 | -1 | 0.786 |
CSK |
0.739 | -0.086 | 2 | 0.824 |
EGFR |
0.737 | -0.057 | 1 | 0.679 |
EPHA2 |
0.737 | 0.008 | -1 | 0.767 |
CK1G3 |
0.735 | -0.142 | -3 | 0.226 |
FGFR4 |
0.734 | -0.075 | -1 | 0.773 |
MUSK |
0.733 | -0.091 | 1 | 0.681 |
PTK2 |
0.733 | -0.026 | -1 | 0.711 |
FES |
0.731 | -0.002 | -1 | 0.756 |
IGF1R |
0.730 | -0.097 | 3 | 0.720 |
SYK |
0.728 | -0.041 | -1 | 0.708 |
YANK2 |
0.726 | -0.130 | 2 | 0.469 |
ERBB4 |
0.725 | -0.057 | 1 | 0.696 |
CK1G2 |
0.710 | -0.156 | -3 | 0.327 |
ZAP70 |
0.695 | -0.134 | -1 | 0.623 |