Motif 791 (n=139)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S85 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A6NMZ7 | COL6A6 | S819 | ochoa | Collagen alpha-6(VI) chain | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| O00303 | EIF3F | S142 | ochoa | Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03005, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. {ECO:0000269|PubMed:21124883}. |
| O14867 | BACH1 | S387 | ochoa | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}. |
| O43776 | NARS1 | S48 | ochoa | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) | Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}. |
| O75152 | ZC3H11A | S452 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75334 | PPFIA2 | S260 | ochoa | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269|PubMed:30021165, ECO:0000269|PubMed:9624153}. |
| O75475 | PSIP1 | S208 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| P05814 | CSN2 | S21 | psp | Beta-casein | Important role in determination of the surface properties of the casein micelles. |
| P07305 | H1-0 | S92 | ochoa | Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] | Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division. |
| P11413 | G6PD | S486 | psp | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
| P12883 | MYH7 | S1596 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1598 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P14866 | HNRNPL | S258 | ochoa | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
| P15884 | TCF4 | S543 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P16157 | ANK1 | S834 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P17181 | IFNAR1 | S535 | psp | Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:21854986, PubMed:7665574). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (PubMed:21854986, PubMed:32972995, PubMed:7526154, PubMed:7665574, PubMed:7813427). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:19561067, PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427, PubMed:9121453). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:31270247, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33252644, ECO:0000269|PubMed:35442418, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:9121453}. |
| P20810 | CAST | S440 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P22059 | OSBP | S198 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P24385 | CCND1 | S43 | ochoa | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8302605). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529). {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:1827756, ECO:0000269|PubMed:1833066, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19412162, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:8114739, ECO:0000269|PubMed:8302605, ECO:0000269|PubMed:9106657}. |
| P24539 | ATP5PB | S226 | ochoa | ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P25189 | MPZ | S226 | ochoa | Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero) | Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. {ECO:0000269|PubMed:10545037, ECO:0000269|PubMed:18337304}. |
| P29466 | CASP1 | S306 | ochoa | Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] | Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:26375003, PubMed:32051255, PubMed:37993714, PubMed:7876192, PubMed:9334240). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:32051255, PubMed:7876192). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:15498465, PubMed:1574116, PubMed:7876192). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:26375003). In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32051255, PubMed:32109412, PubMed:32553275). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:22464733). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547). {ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:1574116, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32553275, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7876192, ECO:0000269|PubMed:9334240}.; FUNCTION: [Isoform Delta]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}.; FUNCTION: [Isoform Epsilon]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}. |
| P31949 | S100A11 | S71 | ochoa | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
| P33527 | ABCC1 | S288 | ochoa | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}. |
| P33981 | TTK | S317 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P34741 | SDC2 | S178 | ochoa | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) | Cell surface proteoglycan which regulates dendritic arbor morphogenesis. {ECO:0000250|UniProtKB:P43407}. |
| P35580 | MYH10 | S1012 | ochoa | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35606 | COPB2 | S787 | ochoa | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| P38398 | BRCA1 | S1164 | ochoa|psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40227 | CCT6A | S246 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P40925 | MDH1 | S189 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P45379 | TNNT2 | S208 | psp | Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P52565 | ARHGDIA | S148 | ochoa | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P52566 | ARHGDIB | S145 | ochoa | Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}. |
| P54132 | BLM | S269 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P82094 | TMF1 | S214 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q00688 | FKBP3 | S77 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q01118 | SCN7A | S791 | ochoa | Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) | Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (PubMed:26537257). {ECO:0000250|UniProtKB:B1AYL1, ECO:0000269|PubMed:26537257, ECO:0000269|PubMed:35301303}. |
| Q02952 | AKAP12 | S388 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05655 | PRKCD | S215 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q07157 | TJP1 | S1617 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q09666 | AHNAK | S691 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12893 | TMEM115 | S306 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
| Q13043 | STK4 | S40 | psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13554 | CAMK2B | S397 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13555 | CAMK2G | S311 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | S333 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q14152 | EIF3A | S584 | ochoa|psp | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q14156 | EFR3A | S738 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14690 | PDCD11 | S1010 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14690 | PDCD11 | S1317 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q15058 | KIF14 | S1044 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15424 | SAFB | S576 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15545 | TAF7 | S264 | ochoa|psp | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q3KQU3 | MAP7D1 | S809 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q5F1R6 | DNAJC21 | S423 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5JRA6 | MIA3 | S189 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5TBB1 | RNASEH2B | S252 | ochoa | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
| Q5VT25 | CDC42BPA | S750 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VUA4 | ZNF318 | S237 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VZ89 | DENND4C | S538 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q68EM7 | ARHGAP17 | S306 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6P0N0 | MIS18BP1 | S191 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6PKG0 | LARP1 | S225 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6UN15 | FIP1L1 | S85 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q8IWZ3 | ANKHD1 | S1679 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8N4N8 | KIF2B | S201 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N5P1 | ZC3H8 | S77 | ochoa | Zinc finger CCCH domain-containing protein 8 | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}. |
| Q8TD16 | BICD2 | S98 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8WUF8 | ARB2A | S220 | ochoa | Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A) | Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}. |
| Q8WVB6 | CHTF18 | S225 | ochoa | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}. |
| Q8WVC0 | LEO1 | S607 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WVF1 | OSCP1 | S274 | ochoa | Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1) | May be involved in drug clearance in the placenta. {ECO:0000269|PubMed:16006562}. |
| Q92526 | CCT6B | S246 | ochoa | T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (Chaperonin containing T-complex polypeptide 1 subunit 6B) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. {ECO:0000305|PubMed:8812458}. |
| Q92539 | LPIN2 | S134 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92541 | RTF1 | S258 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92619 | ARHGAP45 | S194 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92878 | RAD50 | S471 | ochoa | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q96HC4 | PDLIM5 | S214 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JM2 | ZNF462 | S1559 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96KR1 | ZFR | S590 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96L73 | NSD1 | S1139 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96RT1 | ERBIN | S797 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99549 | MPHOSPH8 | S85 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9BQ39 | DDX50 | S41 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BZI7 | UPF3B | S415 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9C0B0 | UNK | S411 | ochoa | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0D2 | CEP295 | S1205 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9H2J7 | SLC6A15 | S19 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H2P0 | ADNP | S738 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H582 | ZNF644 | S1186 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H981 | ACTR8 | S412 | ochoa | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. |
| Q9HCH5 | SYTL2 | S571 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NQS3 | NECTIN3 | S465 | ochoa | Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113) | Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity). {ECO:0000250|UniProtKB:Q9JLB9, ECO:0000269|PubMed:16216929}. |
| Q9NRZ9 | HELLS | S165 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NU22 | MDN1 | S4690 | ochoa | Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) | Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}. |
| Q9NYF8 | BCLAF1 | S485 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZN8 | CNOT2 | S270 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Q9P289 | STK26 | S34 | ochoa | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}. |
| Q9UBB4 | ATXN10 | S448 | ochoa | Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein) | May play a role in the regulation of cytokinesis (PubMed:21857149, PubMed:25666058). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:P28658, ECO:0000250|UniProtKB:Q9ER24, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:25666058}. |
| Q9UI33 | SCN11A | S527 | ochoa | Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN) | Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:10580103, PubMed:12384689, PubMed:24036948, PubMed:24776970, PubMed:25791876, PubMed:26645915). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948, PubMed:24776970, PubMed:25791876, PubMed:26645915). Also involved in rapid BDNF-evoked neuronal depolarization (PubMed:12384689). {ECO:0000269|PubMed:10580103, ECO:0000269|PubMed:12384689, ECO:0000269|PubMed:24036948, ECO:0000269|PubMed:24776970, ECO:0000269|PubMed:25791876, ECO:0000269|PubMed:26645915}. |
| Q9UK61 | TASOR | S694 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKV3 | ACIN1 | S513 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UQM7 | CAMK2A | S333 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2X9 | ZNF281 | S799 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| O00506 | STK25 | S30 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| P60174 | TPI1 | S204 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P30740 | SERPINB1 | S118 | Sugiyama | Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). {ECO:0000269|PubMed:11747453, ECO:0000269|PubMed:23269243, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}. |
| Q01082 | SPTBN1 | S1414 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| O15078 | CEP290 | S1159 | Sugiyama | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}. |
| O15355 | PPM1G | S363 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O75582 | RPS6KA5 | S436 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Q13907 | IDI1 | Y173 | Sugiyama | Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1) | Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO:0000269|PubMed:8806705}. |
| P07333 | CSF1R | S555 | Sugiyama | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) | Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608). {ECO:0000269|PubMed:12882960, ECO:0000269|PubMed:15117969, ECO:0000269|PubMed:16170366, ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:16648572, ECO:0000269|PubMed:17121910, ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:18814279, ECO:0000269|PubMed:19193011, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:30982608, ECO:0000269|PubMed:30982609, ECO:0000269|PubMed:7683918}. |
| Q9UPY6 | WASF3 | S155 | Sugiyama | Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3) | Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:21834987}. |
| Q9Y6W5 | WASF2 | S154 | Sugiyama | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| Q6P1J9 | CDC73 | S174 | Sugiyama | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| P31327 | CPS1 | S896 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P51812 | RPS6KA3 | S432 | Sugiyama | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| Q15349 | RPS6KA2 | S425 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q9UK32 | RPS6KA6 | S436 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9Y3B8 | REXO2 | S92 | Sugiyama | Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease) | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:30926754, PubMed:31588022, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:30926754, PubMed:31588022, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9D8S4, ECO:0000269|PubMed:23741365, ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0000269|PubMed:32365187}.; FUNCTION: [Isoform 3]: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. {ECO:0000269|PubMed:10851236, ECO:0000269|PubMed:16682444}. |
| P57059 | SIK1 | S117 | Sugiyama | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| Q04759 | PRKCQ | S216 | Sugiyama | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| Q13188 | STK3 | S37 | Sugiyama | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q13976 | PRKG1 | S332 | Sugiyama | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| Q15349 | RPS6KA2 | S44 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q6L8Q7 | PDE12 | S266 | Sugiyama | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
| P80303 | NUCB2 | S257 | Sugiyama | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| Q8WUM4 | PDCD6IP | S454 | Sugiyama | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) | Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. |
| P36954 | POLR2I | S73 | Sugiyama | DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5) | Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2I/RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. {ECO:0000250|UniProtKB:P27999, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:9852112}. |
| Q99558 | MAP3K14 | S410 | Sugiyama | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:25406581}. |
| Q9BQI3 | EIF2AK1 | S409 | Sugiyama | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}. |
| Q9Y6E0 | STK24 | S46 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| P56192 | MARS1 | S472 | EPSD|PSP | Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:11714285, ECO:0000269|PubMed:33909043}. |
| Q9NQC3 | RTN4 | S778 | Sugiyama | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q7L7X3 | TAOK1 | S38 | Sugiyama | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q9UL54 | TAOK2 | S38 | Sugiyama | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.648660e-07 | 6.783 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 1.421794e-06 | 5.847 |
| R-HSA-75153 | Apoptotic execution phase | 1.420638e-06 | 5.848 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.682176e-06 | 5.572 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.010022e-05 | 4.996 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.077874e-04 | 3.967 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.259332e-04 | 3.900 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.259332e-04 | 3.900 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.259332e-04 | 3.900 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.259332e-04 | 3.900 |
| R-HSA-199920 | CREB phosphorylation | 1.095230e-04 | 3.960 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.635804e-05 | 4.249 |
| R-HSA-111933 | Calmodulin induced events | 7.899825e-05 | 4.102 |
| R-HSA-111997 | CaM pathway | 7.899825e-05 | 4.102 |
| R-HSA-373760 | L1CAM interactions | 5.426850e-05 | 4.265 |
| R-HSA-74160 | Gene expression (Transcription) | 1.152538e-04 | 3.938 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.315863e-04 | 3.881 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.491474e-04 | 3.826 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.687146e-04 | 3.773 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.687146e-04 | 3.773 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.687146e-04 | 3.773 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.533903e-04 | 3.814 |
| R-HSA-111996 | Ca-dependent events | 1.588368e-04 | 3.799 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.565083e-04 | 3.805 |
| R-HSA-444257 | RSK activation | 1.970756e-04 | 3.705 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.893282e-04 | 3.723 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.075537e-04 | 3.683 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.843089e-04 | 3.546 |
| R-HSA-9620244 | Long-term potentiation | 2.843089e-04 | 3.546 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.201198e-04 | 3.495 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.595244e-04 | 3.444 |
| R-HSA-9675108 | Nervous system development | 3.665654e-04 | 3.436 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.120296e-04 | 3.385 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.479996e-04 | 3.349 |
| R-HSA-5357801 | Programmed Cell Death | 4.616174e-04 | 3.336 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.509969e-04 | 3.259 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 6.697943e-04 | 3.174 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 6.697943e-04 | 3.174 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 6.697943e-04 | 3.174 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 6.697943e-04 | 3.174 |
| R-HSA-112043 | PLC beta mediated events | 6.837591e-04 | 3.165 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 7.355206e-04 | 3.133 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 8.056811e-04 | 3.094 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8.056811e-04 | 3.094 |
| R-HSA-5673000 | RAF activation | 8.056811e-04 | 3.094 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 8.804380e-04 | 3.055 |
| R-HSA-112040 | G-protein mediated events | 9.893528e-04 | 3.005 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.133912e-03 | 2.945 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.222385e-03 | 2.913 |
| R-HSA-2028269 | Signaling by Hippo | 1.455616e-03 | 2.837 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.546077e-03 | 2.811 |
| R-HSA-422475 | Axon guidance | 1.657222e-03 | 2.781 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.546077e-03 | 2.811 |
| R-HSA-198753 | ERK/MAPK targets | 2.334173e-03 | 2.632 |
| R-HSA-9675135 | Diseases of DNA repair | 2.195037e-03 | 2.659 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.195037e-03 | 2.659 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.195037e-03 | 2.659 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.195037e-03 | 2.659 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.195037e-03 | 2.659 |
| R-HSA-109581 | Apoptosis | 2.304665e-03 | 2.637 |
| R-HSA-437239 | Recycling pathway of L1 | 2.344254e-03 | 2.630 |
| R-HSA-397014 | Muscle contraction | 2.397081e-03 | 2.620 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.595174e-03 | 2.586 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 2.979870e-03 | 2.526 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.011068e-03 | 2.521 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.196022e-03 | 2.495 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.388577e-03 | 2.470 |
| R-HSA-5576891 | Cardiac conduction | 3.719000e-03 | 2.430 |
| R-HSA-5578775 | Ion homeostasis | 4.013322e-03 | 2.396 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.470498e-03 | 2.350 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 5.525139e-03 | 2.258 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 5.336171e-03 | 2.273 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 5.525139e-03 | 2.258 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 5.525139e-03 | 2.258 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.049557e-03 | 2.218 |
| R-HSA-111885 | Opioid Signalling | 6.120763e-03 | 2.213 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.344406e-03 | 2.198 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 6.532884e-03 | 2.185 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 6.532884e-03 | 2.185 |
| R-HSA-212436 | Generic Transcription Pathway | 6.865846e-03 | 2.163 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.962412e-03 | 2.157 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.003201e-03 | 2.155 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 7.617562e-03 | 2.118 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 7.684189e-03 | 2.114 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.001134e-02 | 2.000 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.435330e-03 | 2.025 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.919459e-03 | 2.050 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.527126e-03 | 2.069 |
| R-HSA-162582 | Signal Transduction | 8.777767e-03 | 2.057 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.117856e-03 | 2.040 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.146525e-03 | 2.039 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.107565e-02 | 1.956 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.167062e-02 | 1.933 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.185562e-02 | 1.926 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.241945e-02 | 1.906 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.324365e-02 | 1.878 |
| R-HSA-167161 | HIV Transcription Initiation | 1.324365e-02 | 1.878 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.324365e-02 | 1.878 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.436741e-02 | 1.843 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.472058e-02 | 1.832 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.628708e-02 | 1.788 |
| R-HSA-9708530 | Regulation of BACH1 activity | 1.723296e-02 | 1.764 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.723296e-02 | 1.764 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.967714e-02 | 1.706 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.967714e-02 | 1.706 |
| R-HSA-72187 | mRNA 3'-end processing | 2.248132e-02 | 1.648 |
| R-HSA-912446 | Meiotic recombination | 2.152841e-02 | 1.667 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.266155e-02 | 1.645 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.201432e-02 | 1.657 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.248132e-02 | 1.648 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.822103e-02 | 1.739 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.418551e-02 | 1.616 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.508016e-02 | 1.601 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.521380e-02 | 1.598 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 2.937093e-02 | 1.532 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.896945e-02 | 1.409 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.896945e-02 | 1.409 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.896945e-02 | 1.409 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.896945e-02 | 1.409 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.896945e-02 | 1.409 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.896945e-02 | 1.409 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.896945e-02 | 1.409 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.896945e-02 | 1.409 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.896945e-02 | 1.409 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.896945e-02 | 1.409 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.896945e-02 | 1.409 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.636578e-02 | 1.439 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.780831e-02 | 1.422 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.419961e-02 | 1.466 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.207715e-02 | 1.494 |
| R-HSA-162587 | HIV Life Cycle | 3.132196e-02 | 1.504 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.325604e-02 | 1.478 |
| R-HSA-844615 | The AIM2 inflammasome | 3.896945e-02 | 1.409 |
| R-HSA-9839394 | TGFBR3 expression | 3.858348e-02 | 1.414 |
| R-HSA-450294 | MAP kinase activation | 3.207715e-02 | 1.494 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.419961e-02 | 1.466 |
| R-HSA-1266738 | Developmental Biology | 3.211172e-02 | 1.493 |
| R-HSA-2262752 | Cellular responses to stress | 2.997007e-02 | 1.523 |
| R-HSA-877300 | Interferon gamma signaling | 3.264554e-02 | 1.486 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.062270e-02 | 1.391 |
| R-HSA-167172 | Transcription of the HIV genome | 4.079610e-02 | 1.389 |
| R-HSA-448424 | Interleukin-17 signaling | 4.348522e-02 | 1.362 |
| R-HSA-5693538 | Homology Directed Repair | 4.355332e-02 | 1.361 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.626092e-02 | 1.335 |
| R-HSA-73886 | Chromosome Maintenance | 4.660013e-02 | 1.332 |
| R-HSA-3371556 | Cellular response to heat stress | 4.660013e-02 | 1.332 |
| R-HSA-4086398 | Ca2+ pathway | 4.768096e-02 | 1.322 |
| R-HSA-209563 | Axonal growth stimulation | 4.847365e-02 | 1.314 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 4.847365e-02 | 1.314 |
| R-HSA-844623 | The IPAF inflammasome | 4.847365e-02 | 1.314 |
| R-HSA-8852135 | Protein ubiquitination | 5.058484e-02 | 1.296 |
| R-HSA-194138 | Signaling by VEGF | 5.193570e-02 | 1.285 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.290485e-02 | 1.277 |
| R-HSA-69481 | G2/M Checkpoints | 5.415974e-02 | 1.266 |
| R-HSA-112316 | Neuronal System | 5.637638e-02 | 1.249 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 5.788443e-02 | 1.237 |
| R-HSA-191650 | Regulation of gap junction activity | 5.788443e-02 | 1.237 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.788443e-02 | 1.237 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 5.788443e-02 | 1.237 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.021538e-02 | 1.220 |
| R-HSA-1640170 | Cell Cycle | 6.065789e-02 | 1.217 |
| R-HSA-390522 | Striated Muscle Contraction | 6.066668e-02 | 1.217 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 6.066668e-02 | 1.217 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 6.066668e-02 | 1.217 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 6.066668e-02 | 1.217 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 7.642941e-02 | 1.117 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 8.556540e-02 | 1.068 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 6.333572e-02 | 1.198 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 6.333572e-02 | 1.198 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.146368e-02 | 1.146 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.912697e-02 | 1.102 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 9.200796e-02 | 1.036 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 6.333572e-02 | 1.198 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 6.720272e-02 | 1.173 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.644528e-02 | 1.117 |
| R-HSA-1500620 | Meiosis | 6.634595e-02 | 1.178 |
| R-HSA-391251 | Protein folding | 8.221092e-02 | 1.085 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 8.899851e-02 | 1.051 |
| R-HSA-447043 | Neurofascin interactions | 8.556540e-02 | 1.068 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.140475e-02 | 1.212 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 8.556540e-02 | 1.068 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 8.601280e-02 | 1.065 |
| R-HSA-73894 | DNA Repair | 8.617982e-02 | 1.065 |
| R-HSA-447038 | NrCAM interactions | 6.720272e-02 | 1.173 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.070402e-02 | 1.151 |
| R-HSA-199991 | Membrane Trafficking | 7.110399e-02 | 1.148 |
| R-HSA-2682334 | EPH-Ephrin signaling | 8.221092e-02 | 1.085 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.790131e-02 | 1.056 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 7.724765e-02 | 1.112 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.262299e-02 | 1.139 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 8.013645e-02 | 1.096 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.486389e-02 | 1.126 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.918633e-02 | 1.050 |
| R-HSA-157579 | Telomere Maintenance | 9.360916e-02 | 1.029 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 9.360916e-02 | 1.029 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 9.461158e-02 | 1.024 |
| R-HSA-447041 | CHL1 interactions | 9.461158e-02 | 1.024 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 9.556941e-02 | 1.020 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 9.556941e-02 | 1.020 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 9.556941e-02 | 1.020 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.662619e-02 | 1.015 |
| R-HSA-195721 | Signaling by WNT | 9.881139e-02 | 1.005 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.995010e-02 | 1.000 |
| R-HSA-162906 | HIV Infection | 1.012304e-01 | 0.995 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.012374e-01 | 0.995 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.012374e-01 | 0.995 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.012374e-01 | 0.995 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.035688e-01 | 0.985 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.075225e-01 | 0.969 |
| R-HSA-913531 | Interferon Signaling | 1.094959e-01 | 0.961 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.118400e-01 | 0.951 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.118400e-01 | 0.951 |
| R-HSA-448706 | Interleukin-1 processing | 1.124380e-01 | 0.949 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.124380e-01 | 0.949 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.124380e-01 | 0.949 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 1.470511e-01 | 0.833 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 1.470511e-01 | 0.833 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.554927e-01 | 0.808 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.554927e-01 | 0.808 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.884367e-01 | 0.725 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 1.884367e-01 | 0.725 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 1.884367e-01 | 0.725 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 1.964712e-01 | 0.707 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.123038e-01 | 0.673 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.201034e-01 | 0.657 |
| R-HSA-72649 | Translation initiation complex formation | 1.269617e-01 | 0.896 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.336155e-01 | 0.874 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.927629e-01 | 0.715 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.999445e-01 | 0.699 |
| R-HSA-72172 | mRNA Splicing | 1.846352e-01 | 0.734 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.633366e-01 | 0.787 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.437396e-01 | 0.842 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.714489e-01 | 0.766 |
| R-HSA-418457 | cGMP effects | 1.638512e-01 | 0.786 |
| R-HSA-162592 | Integration of provirus | 1.385257e-01 | 0.858 |
| R-HSA-4641265 | Repression of WNT target genes | 1.470511e-01 | 0.833 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.385257e-01 | 0.858 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.470511e-01 | 0.833 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.554927e-01 | 0.808 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.554927e-01 | 0.808 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.044266e-01 | 0.689 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.044266e-01 | 0.689 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.123038e-01 | 0.673 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.540189e-01 | 0.812 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.831825e-01 | 0.737 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 1.212200e-01 | 0.916 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 1.554927e-01 | 0.808 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.470511e-01 | 0.833 |
| R-HSA-164843 | 2-LTR circle formation | 1.212200e-01 | 0.916 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.385257e-01 | 0.858 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.721275e-01 | 0.764 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.044266e-01 | 0.689 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.278263e-01 | 0.642 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.403467e-01 | 0.853 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.044266e-01 | 0.689 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.278263e-01 | 0.642 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.574769e-01 | 0.803 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.891851e-01 | 0.723 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.748407e-01 | 0.757 |
| R-HSA-379724 | tRNA Aminoacylation | 1.471496e-01 | 0.832 |
| R-HSA-418597 | G alpha (z) signalling events | 1.302786e-01 | 0.885 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.430154e-01 | 0.845 |
| R-HSA-180786 | Extension of Telomeres | 1.437396e-01 | 0.842 |
| R-HSA-1474165 | Reproduction | 1.782532e-01 | 0.749 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 1.212200e-01 | 0.916 |
| R-HSA-3928664 | Ephrin signaling | 2.044266e-01 | 0.689 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 1.638512e-01 | 0.786 |
| R-HSA-449836 | Other interleukin signaling | 2.123038e-01 | 0.673 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.956615e-01 | 0.708 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.471496e-01 | 0.832 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.212200e-01 | 0.916 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.803224e-01 | 0.744 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.201034e-01 | 0.657 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.638512e-01 | 0.786 |
| R-HSA-392517 | Rap1 signalling | 2.123038e-01 | 0.673 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.201034e-01 | 0.657 |
| R-HSA-8983711 | OAS antiviral response | 1.470511e-01 | 0.833 |
| R-HSA-2559583 | Cellular Senescence | 1.376587e-01 | 0.861 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.956615e-01 | 0.708 |
| R-HSA-9758890 | Transport of RCbl within the body | 1.299156e-01 | 0.886 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 1.471496e-01 | 0.832 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.033518e-01 | 0.692 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 1.964712e-01 | 0.707 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.181984e-01 | 0.927 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.253023e-01 | 0.647 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.289466e-01 | 0.640 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.295766e-01 | 0.887 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.203475e-01 | 0.920 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.225110e-01 | 0.912 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.472069e-01 | 0.832 |
| R-HSA-373753 | Nephrin family interactions | 2.201034e-01 | 0.657 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.225110e-01 | 0.912 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.472069e-01 | 0.832 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.542066e-01 | 0.812 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.542066e-01 | 0.812 |
| R-HSA-373755 | Semaphorin interactions | 1.574769e-01 | 0.803 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.290864e-01 | 0.889 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.357846e-01 | 0.867 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.749740e-01 | 0.757 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.709308e-01 | 0.767 |
| R-HSA-5218859 | Regulated Necrosis | 1.749740e-01 | 0.757 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.123038e-01 | 0.673 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.289994e-01 | 0.640 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.574769e-01 | 0.803 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.963495e-01 | 0.707 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.143982e-01 | 0.669 |
| R-HSA-166520 | Signaling by NTRKs | 2.289994e-01 | 0.640 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.999445e-01 | 0.699 |
| R-HSA-983712 | Ion channel transport | 1.539712e-01 | 0.813 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.325951e-01 | 0.633 |
| R-HSA-8953854 | Metabolism of RNA | 2.326255e-01 | 0.633 |
| R-HSA-9694614 | Attachment and Entry | 2.354732e-01 | 0.628 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.354732e-01 | 0.628 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.362472e-01 | 0.627 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.399025e-01 | 0.620 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.399025e-01 | 0.620 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.430448e-01 | 0.614 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.430448e-01 | 0.614 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.430448e-01 | 0.614 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.430448e-01 | 0.614 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.435607e-01 | 0.613 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.505419e-01 | 0.601 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.505419e-01 | 0.601 |
| R-HSA-3000170 | Syndecan interactions | 2.505419e-01 | 0.601 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.505419e-01 | 0.601 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.579652e-01 | 0.588 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.579652e-01 | 0.588 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.579652e-01 | 0.588 |
| R-HSA-429947 | Deadenylation of mRNA | 2.579652e-01 | 0.588 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.579652e-01 | 0.588 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.579652e-01 | 0.588 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.579652e-01 | 0.588 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.579652e-01 | 0.588 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.653154e-01 | 0.576 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.653154e-01 | 0.576 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.653154e-01 | 0.576 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.653154e-01 | 0.576 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.653154e-01 | 0.576 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.725933e-01 | 0.564 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.725933e-01 | 0.564 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.725933e-01 | 0.564 |
| R-HSA-525793 | Myogenesis | 2.725933e-01 | 0.564 |
| R-HSA-70635 | Urea cycle | 2.725933e-01 | 0.564 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.725933e-01 | 0.564 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.725933e-01 | 0.564 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.797995e-01 | 0.553 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.797995e-01 | 0.553 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.797995e-01 | 0.553 |
| R-HSA-8949613 | Cristae formation | 2.797995e-01 | 0.553 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.797995e-01 | 0.553 |
| R-HSA-75109 | Triglyceride biosynthesis | 2.797995e-01 | 0.553 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.797995e-01 | 0.553 |
| R-HSA-1483213 | Synthesis of PE | 2.797995e-01 | 0.553 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.797995e-01 | 0.553 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.797995e-01 | 0.553 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.838740e-01 | 0.547 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.869348e-01 | 0.542 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.869348e-01 | 0.542 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.869348e-01 | 0.542 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.869348e-01 | 0.542 |
| R-HSA-622312 | Inflammasomes | 2.869348e-01 | 0.542 |
| R-HSA-5620971 | Pyroptosis | 2.869348e-01 | 0.542 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.875361e-01 | 0.541 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.875361e-01 | 0.541 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.920682e-01 | 0.535 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.928163e-01 | 0.533 |
| R-HSA-72086 | mRNA Capping | 2.939998e-01 | 0.532 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.939998e-01 | 0.532 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.939998e-01 | 0.532 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.948540e-01 | 0.530 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.985093e-01 | 0.525 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.009101e-01 | 0.522 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.009953e-01 | 0.521 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.009953e-01 | 0.521 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.009953e-01 | 0.521 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.009953e-01 | 0.521 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.009953e-01 | 0.521 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.021616e-01 | 0.520 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.058108e-01 | 0.515 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.079218e-01 | 0.512 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.079218e-01 | 0.512 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.079218e-01 | 0.512 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.079218e-01 | 0.512 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.094566e-01 | 0.509 |
| R-HSA-416476 | G alpha (q) signalling events | 3.125630e-01 | 0.505 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.147802e-01 | 0.502 |
| R-HSA-2024096 | HS-GAG degradation | 3.147802e-01 | 0.502 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.147802e-01 | 0.502 |
| R-HSA-9833110 | RSV-host interactions | 3.203701e-01 | 0.494 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.215710e-01 | 0.493 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.215710e-01 | 0.493 |
| R-HSA-189483 | Heme degradation | 3.282949e-01 | 0.484 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.282949e-01 | 0.484 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.348561e-01 | 0.475 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.348561e-01 | 0.475 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.348561e-01 | 0.475 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.349526e-01 | 0.475 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.349526e-01 | 0.475 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 3.349526e-01 | 0.475 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.349526e-01 | 0.475 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.384642e-01 | 0.470 |
| R-HSA-6798695 | Neutrophil degranulation | 3.394889e-01 | 0.469 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.415447e-01 | 0.467 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.468909e-01 | 0.460 |
| R-HSA-2022928 | HS-GAG biosynthesis | 3.480719e-01 | 0.458 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.480719e-01 | 0.458 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.480719e-01 | 0.458 |
| R-HSA-68877 | Mitotic Prometaphase | 3.522945e-01 | 0.453 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.545348e-01 | 0.450 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.545348e-01 | 0.450 |
| R-HSA-419037 | NCAM1 interactions | 3.545348e-01 | 0.450 |
| R-HSA-8948216 | Collagen chain trimerization | 3.545348e-01 | 0.450 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.599821e-01 | 0.444 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.609340e-01 | 0.443 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.672702e-01 | 0.435 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.672702e-01 | 0.435 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 3.672702e-01 | 0.435 |
| R-HSA-71336 | Pentose phosphate pathway | 3.672702e-01 | 0.435 |
| R-HSA-9648002 | RAS processing | 3.672702e-01 | 0.435 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.706469e-01 | 0.431 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.706469e-01 | 0.431 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.735439e-01 | 0.428 |
| R-HSA-167169 | HIV Transcription Elongation | 3.735439e-01 | 0.428 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.735439e-01 | 0.428 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.735439e-01 | 0.428 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.735439e-01 | 0.428 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.735439e-01 | 0.428 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.797558e-01 | 0.420 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.797558e-01 | 0.420 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.797558e-01 | 0.420 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.797558e-01 | 0.420 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.797558e-01 | 0.420 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.859065e-01 | 0.414 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.882633e-01 | 0.411 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.919966e-01 | 0.407 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 3.919966e-01 | 0.407 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.039972e-01 | 0.394 |
| R-HSA-69236 | G1 Phase | 4.039972e-01 | 0.394 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.039972e-01 | 0.394 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.039972e-01 | 0.394 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.039972e-01 | 0.394 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 4.039972e-01 | 0.394 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.039972e-01 | 0.394 |
| R-HSA-373752 | Netrin-1 signaling | 4.039972e-01 | 0.394 |
| R-HSA-774815 | Nucleosome assembly | 4.099090e-01 | 0.387 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.099090e-01 | 0.387 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.099090e-01 | 0.387 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 4.099090e-01 | 0.387 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.099090e-01 | 0.387 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.157625e-01 | 0.381 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.157625e-01 | 0.381 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.157625e-01 | 0.381 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.157625e-01 | 0.381 |
| R-HSA-418594 | G alpha (i) signalling events | 4.210434e-01 | 0.376 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.215582e-01 | 0.375 |
| R-HSA-1483191 | Synthesis of PC | 4.215582e-01 | 0.375 |
| R-HSA-70263 | Gluconeogenesis | 4.272969e-01 | 0.369 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.272969e-01 | 0.369 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.329789e-01 | 0.364 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.329981e-01 | 0.364 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.386050e-01 | 0.358 |
| R-HSA-2514856 | The phototransduction cascade | 4.441755e-01 | 0.352 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.443610e-01 | 0.352 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.478843e-01 | 0.349 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.496912e-01 | 0.347 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.496912e-01 | 0.347 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.496912e-01 | 0.347 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.496912e-01 | 0.347 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.502050e-01 | 0.347 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.530580e-01 | 0.344 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.551524e-01 | 0.342 |
| R-HSA-1221632 | Meiotic synapsis | 4.551524e-01 | 0.342 |
| R-HSA-449147 | Signaling by Interleukins | 4.619820e-01 | 0.335 |
| R-HSA-9664407 | Parasite infection | 4.629369e-01 | 0.334 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.629369e-01 | 0.334 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.629369e-01 | 0.334 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.659138e-01 | 0.332 |
| R-HSA-9753281 | Paracetamol ADME | 4.659138e-01 | 0.332 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.662068e-01 | 0.331 |
| R-HSA-8939211 | ESR-mediated signaling | 4.709798e-01 | 0.327 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.712150e-01 | 0.327 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.712150e-01 | 0.327 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.727115e-01 | 0.325 |
| R-HSA-168249 | Innate Immune System | 4.742875e-01 | 0.324 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.764639e-01 | 0.322 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.764639e-01 | 0.322 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.816611e-01 | 0.317 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.816611e-01 | 0.317 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 4.868070e-01 | 0.313 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.868070e-01 | 0.313 |
| R-HSA-8979227 | Triglyceride metabolism | 4.868070e-01 | 0.313 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.868070e-01 | 0.313 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.868070e-01 | 0.313 |
| R-HSA-2187338 | Visual phototransduction | 4.887642e-01 | 0.311 |
| R-HSA-983189 | Kinesins | 4.919021e-01 | 0.308 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.919021e-01 | 0.308 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.969469e-01 | 0.304 |
| R-HSA-1442490 | Collagen degradation | 4.969469e-01 | 0.304 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.004335e-01 | 0.301 |
| R-HSA-9707616 | Heme signaling | 5.019420e-01 | 0.299 |
| R-HSA-186797 | Signaling by PDGF | 5.019420e-01 | 0.299 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.068877e-01 | 0.295 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.068877e-01 | 0.295 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.068877e-01 | 0.295 |
| R-HSA-8848021 | Signaling by PTK6 | 5.068877e-01 | 0.295 |
| R-HSA-73887 | Death Receptor Signaling | 5.107218e-01 | 0.292 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.117847e-01 | 0.291 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.182460e-01 | 0.285 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.214341e-01 | 0.283 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.214341e-01 | 0.283 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.261875e-01 | 0.279 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.290486e-01 | 0.277 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.295988e-01 | 0.276 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.308939e-01 | 0.275 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.308939e-01 | 0.275 |
| R-HSA-388396 | GPCR downstream signalling | 5.360996e-01 | 0.271 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.401679e-01 | 0.267 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.401679e-01 | 0.267 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.401679e-01 | 0.267 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.410075e-01 | 0.267 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.447364e-01 | 0.264 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.447364e-01 | 0.264 |
| R-HSA-3000178 | ECM proteoglycans | 5.447364e-01 | 0.264 |
| R-HSA-975634 | Retinoid metabolism and transport | 5.447364e-01 | 0.264 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.447364e-01 | 0.264 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.447364e-01 | 0.264 |
| R-HSA-189445 | Metabolism of porphyrins | 5.447364e-01 | 0.264 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.492597e-01 | 0.260 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.492597e-01 | 0.260 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.492597e-01 | 0.260 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.537384e-01 | 0.257 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.581729e-01 | 0.253 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.614292e-01 | 0.251 |
| R-HSA-380287 | Centrosome maturation | 5.625635e-01 | 0.250 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.625635e-01 | 0.250 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.669108e-01 | 0.246 |
| R-HSA-5689603 | UCH proteinases | 5.669108e-01 | 0.246 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.671445e-01 | 0.246 |
| R-HSA-68886 | M Phase | 5.698407e-01 | 0.244 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.754770e-01 | 0.240 |
| R-HSA-216083 | Integrin cell surface interactions | 5.754770e-01 | 0.240 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.754770e-01 | 0.240 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.768354e-01 | 0.239 |
| R-HSA-9658195 | Leishmania infection | 5.768354e-01 | 0.239 |
| R-HSA-9659379 | Sensory processing of sound | 5.796967e-01 | 0.237 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.838748e-01 | 0.234 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.838748e-01 | 0.234 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 5.880116e-01 | 0.231 |
| R-HSA-168256 | Immune System | 5.947330e-01 | 0.226 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.961630e-01 | 0.225 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.001783e-01 | 0.222 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.041540e-01 | 0.219 |
| R-HSA-69275 | G2/M Transition | 6.056511e-01 | 0.218 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.080904e-01 | 0.216 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.080904e-01 | 0.216 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.109371e-01 | 0.214 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.109371e-01 | 0.214 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.196678e-01 | 0.208 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.196678e-01 | 0.208 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.213479e-01 | 0.207 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.271965e-01 | 0.203 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.271965e-01 | 0.203 |
| R-HSA-202424 | Downstream TCR signaling | 6.271965e-01 | 0.203 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.309052e-01 | 0.200 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.415271e-01 | 0.193 |
| R-HSA-428157 | Sphingolipid metabolism | 6.439896e-01 | 0.191 |
| R-HSA-1474290 | Collagen formation | 6.453767e-01 | 0.190 |
| R-HSA-372790 | Signaling by GPCR | 6.488065e-01 | 0.188 |
| R-HSA-1500931 | Cell-Cell communication | 6.510400e-01 | 0.186 |
| R-HSA-72766 | Translation | 6.563784e-01 | 0.183 |
| R-HSA-190236 | Signaling by FGFR | 6.626756e-01 | 0.179 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.660334e-01 | 0.177 |
| R-HSA-8957322 | Metabolism of steroids | 6.666501e-01 | 0.176 |
| R-HSA-70171 | Glycolysis | 6.693579e-01 | 0.174 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.693579e-01 | 0.174 |
| R-HSA-1474244 | Extracellular matrix organization | 6.798911e-01 | 0.168 |
| R-HSA-9679506 | SARS-CoV Infections | 6.807725e-01 | 0.167 |
| R-HSA-68882 | Mitotic Anaphase | 6.815998e-01 | 0.166 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.823305e-01 | 0.166 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.838400e-01 | 0.165 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.854939e-01 | 0.164 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.854939e-01 | 0.164 |
| R-HSA-418990 | Adherens junctions interactions | 6.860674e-01 | 0.164 |
| R-HSA-418346 | Platelet homeostasis | 6.917269e-01 | 0.160 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.917269e-01 | 0.160 |
| R-HSA-8951664 | Neddylation | 6.926728e-01 | 0.159 |
| R-HSA-211000 | Gene Silencing by RNA | 6.947972e-01 | 0.158 |
| R-HSA-202403 | TCR signaling | 7.038271e-01 | 0.153 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.038271e-01 | 0.153 |
| R-HSA-6803157 | Antimicrobial peptides | 7.067776e-01 | 0.151 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.096989e-01 | 0.149 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.096989e-01 | 0.149 |
| R-HSA-9824446 | Viral Infection Pathways | 7.108862e-01 | 0.148 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.125914e-01 | 0.147 |
| R-HSA-392499 | Metabolism of proteins | 7.145444e-01 | 0.146 |
| R-HSA-72312 | rRNA processing | 7.159236e-01 | 0.145 |
| R-HSA-1643685 | Disease | 7.179373e-01 | 0.144 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.199900e-01 | 0.143 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.210979e-01 | 0.142 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.238774e-01 | 0.140 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.238774e-01 | 0.140 |
| R-HSA-70326 | Glucose metabolism | 7.293541e-01 | 0.137 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.293541e-01 | 0.137 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.293541e-01 | 0.137 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.293541e-01 | 0.137 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.347229e-01 | 0.134 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.354871e-01 | 0.133 |
| R-HSA-68875 | Mitotic Prophase | 7.373675e-01 | 0.132 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.451450e-01 | 0.128 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.451450e-01 | 0.128 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.476863e-01 | 0.126 |
| R-HSA-4839726 | Chromatin organization | 7.489568e-01 | 0.126 |
| R-HSA-421270 | Cell-cell junction organization | 7.526196e-01 | 0.123 |
| R-HSA-69206 | G1/S Transition | 7.526936e-01 | 0.123 |
| R-HSA-5688426 | Deubiquitination | 7.598082e-01 | 0.119 |
| R-HSA-9909396 | Circadian clock | 7.717544e-01 | 0.113 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.736479e-01 | 0.111 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.872305e-01 | 0.104 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.915456e-01 | 0.102 |
| R-HSA-597592 | Post-translational protein modification | 7.924939e-01 | 0.101 |
| R-HSA-446728 | Cell junction organization | 7.977401e-01 | 0.098 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.996627e-01 | 0.097 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.016633e-01 | 0.096 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.056053e-01 | 0.094 |
| R-HSA-69242 | S Phase | 8.094694e-01 | 0.092 |
| R-HSA-9758941 | Gastrulation | 8.113727e-01 | 0.091 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.132572e-01 | 0.090 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.169701e-01 | 0.088 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.169701e-01 | 0.088 |
| R-HSA-2142753 | Arachidonate metabolism | 8.169701e-01 | 0.088 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.206096e-01 | 0.086 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.206096e-01 | 0.086 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.224023e-01 | 0.085 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.377563e-01 | 0.077 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.532733e-01 | 0.069 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.532733e-01 | 0.069 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.535793e-01 | 0.069 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.546611e-01 | 0.068 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.561949e-01 | 0.067 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.561949e-01 | 0.067 |
| R-HSA-611105 | Respiratory electron transport | 8.604693e-01 | 0.065 |
| R-HSA-168255 | Influenza Infection | 8.618659e-01 | 0.065 |
| R-HSA-3781865 | Diseases of glycosylation | 8.686431e-01 | 0.061 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.759097e-01 | 0.058 |
| R-HSA-5617833 | Cilium Assembly | 8.763408e-01 | 0.057 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.800198e-01 | 0.056 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.835900e-01 | 0.054 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.915153e-01 | 0.050 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.915153e-01 | 0.050 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.915153e-01 | 0.050 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.967569e-01 | 0.047 |
| R-HSA-109582 | Hemostasis | 9.060619e-01 | 0.043 |
| R-HSA-9748784 | Drug ADME | 9.076737e-01 | 0.042 |
| R-HSA-1280218 | Adaptive Immune System | 9.110432e-01 | 0.040 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.182012e-01 | 0.037 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.237820e-01 | 0.034 |
| R-HSA-157118 | Signaling by NOTCH | 9.260564e-01 | 0.033 |
| R-HSA-5663205 | Infectious disease | 9.272153e-01 | 0.033 |
| R-HSA-382551 | Transport of small molecules | 9.372157e-01 | 0.028 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.516446e-01 | 0.022 |
| R-HSA-1483257 | Phospholipid metabolism | 9.576111e-01 | 0.019 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.828434e-01 | 0.008 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.840250e-01 | 0.007 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.851257e-01 | 0.007 |
| R-HSA-8978868 | Fatty acid metabolism | 9.865686e-01 | 0.006 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.883083e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.890502e-01 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 9.994327e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.997641e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.863 | 0.211 | 2 | 0.855 |
DSTYK |
0.856 | 0.208 | 2 | 0.875 |
CDC7 |
0.852 | 0.112 | 1 | 0.856 |
MOS |
0.849 | 0.158 | 1 | 0.882 |
CAMK2G |
0.848 | 0.100 | 2 | 0.799 |
GRK6 |
0.845 | 0.176 | 1 | 0.881 |
PIM3 |
0.845 | 0.070 | -3 | 0.784 |
IKKB |
0.844 | -0.045 | -2 | 0.730 |
MTOR |
0.843 | 0.012 | 1 | 0.811 |
GCN2 |
0.843 | -0.037 | 2 | 0.775 |
PRPK |
0.843 | -0.077 | -1 | 0.800 |
FAM20C |
0.843 | 0.139 | 2 | 0.592 |
GRK1 |
0.843 | 0.127 | -2 | 0.761 |
NDR2 |
0.842 | 0.052 | -3 | 0.777 |
RAF1 |
0.842 | -0.016 | 1 | 0.857 |
CLK3 |
0.841 | 0.118 | 1 | 0.769 |
TBK1 |
0.840 | -0.029 | 1 | 0.790 |
RSK2 |
0.840 | 0.093 | -3 | 0.719 |
BMPR2 |
0.839 | 0.036 | -2 | 0.868 |
NEK6 |
0.839 | 0.087 | -2 | 0.854 |
IKKE |
0.839 | -0.027 | 1 | 0.785 |
TGFBR2 |
0.839 | 0.111 | -2 | 0.843 |
PDHK4 |
0.839 | -0.155 | 1 | 0.870 |
GRK7 |
0.838 | 0.235 | 1 | 0.824 |
GRK5 |
0.838 | -0.001 | -3 | 0.830 |
GRK4 |
0.837 | 0.058 | -2 | 0.814 |
TGFBR1 |
0.837 | 0.189 | -2 | 0.803 |
ULK2 |
0.837 | -0.089 | 2 | 0.757 |
PDHK1 |
0.837 | -0.085 | 1 | 0.863 |
IKKA |
0.837 | 0.043 | -2 | 0.717 |
BMPR1B |
0.837 | 0.199 | 1 | 0.793 |
CAMK1B |
0.837 | -0.006 | -3 | 0.807 |
MST4 |
0.836 | 0.090 | 2 | 0.883 |
PLK1 |
0.836 | 0.192 | -2 | 0.856 |
NEK7 |
0.835 | -0.009 | -3 | 0.789 |
ATR |
0.834 | -0.027 | 1 | 0.820 |
BCKDK |
0.833 | -0.039 | -1 | 0.799 |
CAMK2B |
0.833 | 0.121 | 2 | 0.790 |
ACVR2A |
0.833 | 0.212 | -2 | 0.853 |
ATM |
0.833 | 0.063 | 1 | 0.767 |
PLK3 |
0.833 | 0.165 | 2 | 0.734 |
PKN3 |
0.832 | 0.014 | -3 | 0.778 |
P90RSK |
0.832 | 0.042 | -3 | 0.732 |
ULK1 |
0.831 | -0.097 | -3 | 0.788 |
ALK2 |
0.831 | 0.192 | -2 | 0.817 |
ALK4 |
0.831 | 0.128 | -2 | 0.830 |
CDKL1 |
0.830 | -0.000 | -3 | 0.766 |
PIM1 |
0.830 | 0.075 | -3 | 0.721 |
ACVR2B |
0.830 | 0.193 | -2 | 0.856 |
NDR1 |
0.830 | -0.007 | -3 | 0.769 |
NLK |
0.830 | -0.070 | 1 | 0.799 |
RSK3 |
0.829 | 0.036 | -3 | 0.720 |
CAMK2D |
0.829 | 0.003 | -3 | 0.771 |
P70S6KB |
0.829 | 0.036 | -3 | 0.733 |
MLK1 |
0.829 | -0.065 | 2 | 0.817 |
NUAK2 |
0.828 | -0.007 | -3 | 0.773 |
HUNK |
0.828 | -0.072 | 2 | 0.744 |
CAMK2A |
0.828 | 0.096 | 2 | 0.798 |
KIS |
0.827 | 0.032 | 1 | 0.635 |
PRKD1 |
0.827 | -0.026 | -3 | 0.765 |
MARK4 |
0.827 | 0.003 | 4 | 0.883 |
NIK |
0.827 | -0.083 | -3 | 0.822 |
RIPK3 |
0.826 | -0.098 | 3 | 0.757 |
CAMLCK |
0.826 | -0.043 | -2 | 0.785 |
CK2A2 |
0.826 | 0.271 | 1 | 0.758 |
LATS1 |
0.825 | 0.110 | -3 | 0.800 |
ANKRD3 |
0.825 | -0.035 | 1 | 0.864 |
ERK5 |
0.825 | -0.068 | 1 | 0.735 |
SKMLCK |
0.825 | -0.043 | -2 | 0.760 |
LATS2 |
0.824 | -0.026 | -5 | 0.710 |
RSK4 |
0.824 | 0.080 | -3 | 0.689 |
MAPKAPK2 |
0.824 | 0.038 | -3 | 0.663 |
BMPR1A |
0.824 | 0.183 | 1 | 0.781 |
DLK |
0.824 | -0.093 | 1 | 0.855 |
DAPK2 |
0.824 | -0.059 | -3 | 0.812 |
PKCD |
0.824 | 0.024 | 2 | 0.799 |
DNAPK |
0.823 | 0.092 | 1 | 0.725 |
SRPK1 |
0.823 | 0.025 | -3 | 0.716 |
WNK1 |
0.823 | -0.094 | -2 | 0.769 |
PKN2 |
0.823 | -0.033 | -3 | 0.770 |
PKACG |
0.821 | -0.012 | -2 | 0.676 |
MSK2 |
0.821 | -0.011 | -3 | 0.690 |
CDKL5 |
0.820 | -0.025 | -3 | 0.758 |
NEK9 |
0.820 | -0.114 | 2 | 0.824 |
YSK4 |
0.820 | -0.006 | 1 | 0.798 |
PRKD2 |
0.819 | -0.024 | -3 | 0.696 |
AMPKA1 |
0.819 | -0.053 | -3 | 0.781 |
MSK1 |
0.818 | 0.029 | -3 | 0.695 |
MASTL |
0.818 | -0.262 | -2 | 0.763 |
HIPK4 |
0.818 | -0.040 | 1 | 0.737 |
TSSK2 |
0.818 | -0.060 | -5 | 0.727 |
WNK3 |
0.818 | -0.250 | 1 | 0.823 |
TTBK2 |
0.818 | -0.152 | 2 | 0.650 |
PKR |
0.818 | 0.022 | 1 | 0.816 |
SRPK2 |
0.817 | 0.036 | -3 | 0.635 |
ICK |
0.817 | -0.051 | -3 | 0.793 |
NIM1 |
0.816 | -0.041 | 3 | 0.764 |
TLK2 |
0.816 | 0.025 | 1 | 0.796 |
MAPKAPK3 |
0.816 | -0.082 | -3 | 0.702 |
SRPK3 |
0.816 | 0.028 | -3 | 0.691 |
MLK3 |
0.815 | -0.032 | 2 | 0.757 |
MEK1 |
0.815 | -0.092 | 2 | 0.795 |
BRAF |
0.815 | 0.048 | -4 | 0.793 |
PKACB |
0.815 | 0.043 | -2 | 0.613 |
CK2A1 |
0.815 | 0.239 | 1 | 0.740 |
AURC |
0.814 | -0.004 | -2 | 0.592 |
GSK3A |
0.814 | 0.188 | 4 | 0.624 |
CHAK2 |
0.814 | -0.166 | -1 | 0.743 |
PLK2 |
0.814 | 0.158 | -3 | 0.803 |
GRK2 |
0.813 | -0.018 | -2 | 0.698 |
AURA |
0.813 | 0.007 | -2 | 0.565 |
MLK4 |
0.813 | -0.044 | 2 | 0.728 |
RIPK1 |
0.813 | -0.219 | 1 | 0.816 |
CDK2 |
0.813 | 0.024 | 1 | 0.694 |
PRKX |
0.813 | 0.076 | -3 | 0.605 |
TLK1 |
0.812 | 0.055 | -2 | 0.837 |
GSK3B |
0.812 | 0.151 | 4 | 0.616 |
TSSK1 |
0.812 | -0.059 | -3 | 0.805 |
SIK |
0.812 | -0.004 | -3 | 0.682 |
AMPKA2 |
0.811 | -0.055 | -3 | 0.746 |
CAMK4 |
0.811 | -0.133 | -3 | 0.739 |
CDK8 |
0.811 | -0.061 | 1 | 0.615 |
CDK1 |
0.811 | 0.016 | 1 | 0.582 |
HRI |
0.811 | -0.007 | -2 | 0.869 |
NUAK1 |
0.811 | -0.053 | -3 | 0.716 |
PAK1 |
0.811 | -0.074 | -2 | 0.704 |
CLK2 |
0.810 | 0.091 | -3 | 0.698 |
QSK |
0.810 | -0.012 | 4 | 0.858 |
PKCA |
0.810 | -0.006 | 2 | 0.750 |
DRAK1 |
0.809 | -0.048 | 1 | 0.798 |
MLK2 |
0.809 | -0.211 | 2 | 0.808 |
MEKK3 |
0.809 | -0.052 | 1 | 0.813 |
MARK2 |
0.808 | 0.004 | 4 | 0.803 |
JNK3 |
0.808 | -0.000 | 1 | 0.612 |
CLK4 |
0.808 | -0.000 | -3 | 0.709 |
IRE2 |
0.808 | -0.085 | 2 | 0.721 |
PKCG |
0.808 | -0.046 | 2 | 0.744 |
DYRK2 |
0.808 | -0.033 | 1 | 0.657 |
PASK |
0.808 | 0.058 | -3 | 0.801 |
PERK |
0.808 | -0.026 | -2 | 0.861 |
AURB |
0.807 | -0.029 | -2 | 0.592 |
PLK4 |
0.807 | -0.034 | 2 | 0.576 |
JNK2 |
0.807 | 0.015 | 1 | 0.568 |
PKCB |
0.807 | -0.030 | 2 | 0.757 |
MARK3 |
0.807 | 0.003 | 4 | 0.834 |
NEK2 |
0.807 | -0.129 | 2 | 0.789 |
VRK2 |
0.807 | -0.270 | 1 | 0.865 |
QIK |
0.807 | -0.107 | -3 | 0.756 |
MEKK1 |
0.807 | -0.052 | 1 | 0.827 |
PIM2 |
0.807 | 0.027 | -3 | 0.685 |
ZAK |
0.807 | -0.057 | 1 | 0.822 |
BRSK1 |
0.806 | -0.057 | -3 | 0.718 |
SGK3 |
0.806 | 0.004 | -3 | 0.697 |
MYLK4 |
0.806 | -0.055 | -2 | 0.697 |
PAK3 |
0.806 | -0.131 | -2 | 0.708 |
IRE1 |
0.805 | -0.169 | 1 | 0.756 |
SMG1 |
0.805 | -0.106 | 1 | 0.767 |
CHK1 |
0.805 | -0.086 | -3 | 0.757 |
PKCH |
0.805 | -0.062 | 2 | 0.730 |
AKT2 |
0.804 | 0.010 | -3 | 0.628 |
PRKD3 |
0.804 | -0.072 | -3 | 0.676 |
MEKK2 |
0.804 | -0.033 | 2 | 0.785 |
GRK3 |
0.803 | -0.004 | -2 | 0.658 |
MNK2 |
0.803 | -0.104 | -2 | 0.705 |
CDK5 |
0.803 | -0.013 | 1 | 0.628 |
CLK1 |
0.803 | -0.006 | -3 | 0.679 |
MARK1 |
0.803 | -0.030 | 4 | 0.849 |
PKG2 |
0.803 | -0.032 | -2 | 0.619 |
CDK19 |
0.802 | -0.066 | 1 | 0.571 |
P38A |
0.802 | -0.031 | 1 | 0.634 |
P70S6K |
0.802 | -0.003 | -3 | 0.647 |
MELK |
0.802 | -0.124 | -3 | 0.727 |
PAK2 |
0.801 | -0.122 | -2 | 0.695 |
P38B |
0.801 | -0.018 | 1 | 0.577 |
PRP4 |
0.801 | 0.039 | -3 | 0.802 |
CDK13 |
0.801 | -0.071 | 1 | 0.592 |
PHKG1 |
0.801 | -0.118 | -3 | 0.747 |
MAPKAPK5 |
0.800 | -0.130 | -3 | 0.662 |
MST3 |
0.800 | -0.004 | 2 | 0.830 |
BRSK2 |
0.800 | -0.120 | -3 | 0.732 |
PKACA |
0.800 | 0.015 | -2 | 0.568 |
CDK7 |
0.799 | -0.091 | 1 | 0.615 |
CAMK1G |
0.799 | -0.064 | -3 | 0.693 |
TAO3 |
0.799 | -0.018 | 1 | 0.804 |
CDK18 |
0.799 | -0.028 | 1 | 0.542 |
MNK1 |
0.798 | -0.099 | -2 | 0.728 |
CDK3 |
0.798 | 0.034 | 1 | 0.518 |
PAK6 |
0.798 | -0.089 | -2 | 0.644 |
MEK5 |
0.798 | -0.250 | 2 | 0.803 |
P38G |
0.798 | -0.019 | 1 | 0.493 |
SMMLCK |
0.798 | -0.056 | -3 | 0.760 |
MST2 |
0.797 | 0.041 | 1 | 0.817 |
ERK2 |
0.797 | -0.071 | 1 | 0.610 |
CK1E |
0.797 | -0.045 | -3 | 0.541 |
DCAMKL1 |
0.796 | -0.068 | -3 | 0.707 |
CDK17 |
0.796 | -0.036 | 1 | 0.502 |
ERK1 |
0.796 | -0.053 | 1 | 0.559 |
SNRK |
0.796 | -0.224 | 2 | 0.649 |
CHAK1 |
0.796 | -0.247 | 2 | 0.724 |
CAMKK1 |
0.795 | -0.105 | -2 | 0.743 |
TTBK1 |
0.795 | -0.156 | 2 | 0.566 |
PKCZ |
0.795 | -0.147 | 2 | 0.770 |
EEF2K |
0.795 | 0.029 | 3 | 0.795 |
NEK5 |
0.794 | -0.144 | 1 | 0.813 |
HIPK1 |
0.794 | -0.032 | 1 | 0.668 |
NEK8 |
0.794 | -0.104 | 2 | 0.800 |
CK1G1 |
0.794 | -0.048 | -3 | 0.545 |
WNK4 |
0.793 | -0.186 | -2 | 0.766 |
GAK |
0.793 | -0.014 | 1 | 0.808 |
CDK12 |
0.793 | -0.071 | 1 | 0.567 |
AKT1 |
0.792 | -0.007 | -3 | 0.638 |
PINK1 |
0.792 | -0.227 | 1 | 0.771 |
CAMKK2 |
0.792 | -0.090 | -2 | 0.726 |
DYRK4 |
0.792 | -0.019 | 1 | 0.575 |
HIPK2 |
0.791 | -0.030 | 1 | 0.557 |
CDK16 |
0.791 | 0.007 | 1 | 0.522 |
PHKG2 |
0.791 | -0.102 | -3 | 0.719 |
JNK1 |
0.790 | -0.010 | 1 | 0.573 |
CK1D |
0.790 | -0.036 | -3 | 0.488 |
TAO2 |
0.790 | -0.086 | 2 | 0.841 |
CDK9 |
0.790 | -0.098 | 1 | 0.598 |
PKCT |
0.790 | -0.078 | 2 | 0.746 |
TAK1 |
0.790 | -0.051 | 1 | 0.827 |
DYRK1A |
0.790 | -0.064 | 1 | 0.683 |
DCAMKL2 |
0.790 | -0.096 | -3 | 0.729 |
GCK |
0.789 | -0.013 | 1 | 0.801 |
CK1A2 |
0.789 | -0.037 | -3 | 0.486 |
SSTK |
0.788 | -0.087 | 4 | 0.848 |
DAPK3 |
0.788 | -0.027 | -3 | 0.730 |
NEK11 |
0.788 | -0.182 | 1 | 0.822 |
MST1 |
0.787 | 0.007 | 1 | 0.800 |
SGK1 |
0.787 | 0.041 | -3 | 0.557 |
CAMK1D |
0.787 | -0.048 | -3 | 0.598 |
P38D |
0.786 | -0.015 | 1 | 0.496 |
CDK14 |
0.786 | -0.048 | 1 | 0.596 |
PDK1 |
0.785 | -0.116 | 1 | 0.823 |
HIPK3 |
0.785 | -0.085 | 1 | 0.667 |
DAPK1 |
0.785 | -0.027 | -3 | 0.718 |
AKT3 |
0.784 | 0.019 | -3 | 0.570 |
PKCI |
0.784 | -0.089 | 2 | 0.743 |
IRAK4 |
0.784 | -0.218 | 1 | 0.768 |
TNIK |
0.784 | -0.017 | 3 | 0.801 |
HGK |
0.784 | -0.061 | 3 | 0.807 |
MINK |
0.784 | -0.058 | 1 | 0.792 |
PKCE |
0.783 | -0.028 | 2 | 0.726 |
ERK7 |
0.783 | -0.034 | 2 | 0.545 |
DYRK1B |
0.783 | -0.064 | 1 | 0.600 |
MPSK1 |
0.783 | -0.094 | 1 | 0.730 |
MRCKA |
0.783 | 0.011 | -3 | 0.677 |
DYRK3 |
0.783 | -0.052 | 1 | 0.677 |
LKB1 |
0.782 | -0.142 | -3 | 0.778 |
CDK10 |
0.782 | -0.030 | 1 | 0.575 |
PDHK3_TYR |
0.780 | 0.200 | 4 | 0.923 |
NEK4 |
0.780 | -0.170 | 1 | 0.781 |
IRAK1 |
0.780 | -0.306 | -1 | 0.657 |
MAP3K15 |
0.780 | -0.141 | 1 | 0.799 |
ALPHAK3 |
0.780 | 0.065 | -1 | 0.745 |
HPK1 |
0.780 | -0.065 | 1 | 0.789 |
PAK5 |
0.779 | -0.118 | -2 | 0.582 |
TTK |
0.778 | 0.118 | -2 | 0.856 |
MEK2 |
0.777 | -0.193 | 2 | 0.772 |
RIPK2 |
0.777 | -0.221 | 1 | 0.777 |
YSK1 |
0.777 | -0.061 | 2 | 0.814 |
MRCKB |
0.776 | -0.024 | -3 | 0.666 |
LRRK2 |
0.776 | -0.222 | 2 | 0.820 |
MEKK6 |
0.776 | -0.190 | 1 | 0.789 |
PAK4 |
0.776 | -0.109 | -2 | 0.578 |
NEK1 |
0.776 | -0.139 | 1 | 0.794 |
PKN1 |
0.776 | -0.070 | -3 | 0.654 |
SBK |
0.775 | -0.010 | -3 | 0.509 |
KHS2 |
0.775 | -0.012 | 1 | 0.792 |
LOK |
0.775 | -0.117 | -2 | 0.728 |
KHS1 |
0.774 | -0.048 | 1 | 0.786 |
CAMK1A |
0.774 | -0.053 | -3 | 0.583 |
BMPR2_TYR |
0.773 | 0.072 | -1 | 0.821 |
STK33 |
0.773 | -0.195 | 2 | 0.577 |
SLK |
0.772 | -0.125 | -2 | 0.685 |
ROCK2 |
0.772 | -0.031 | -3 | 0.716 |
CHK2 |
0.772 | -0.078 | -3 | 0.568 |
VRK1 |
0.772 | -0.271 | 2 | 0.790 |
MAP2K6_TYR |
0.772 | 0.080 | -1 | 0.834 |
MAP2K4_TYR |
0.772 | 0.038 | -1 | 0.836 |
EPHA6 |
0.771 | 0.088 | -1 | 0.822 |
DMPK1 |
0.771 | 0.015 | -3 | 0.684 |
PDHK4_TYR |
0.771 | 0.067 | 2 | 0.862 |
OSR1 |
0.770 | -0.057 | 2 | 0.793 |
CDK6 |
0.769 | -0.071 | 1 | 0.566 |
MAK |
0.768 | -0.021 | -2 | 0.620 |
PDHK1_TYR |
0.768 | 0.025 | -1 | 0.851 |
CRIK |
0.767 | 0.017 | -3 | 0.642 |
TESK1_TYR |
0.767 | -0.091 | 3 | 0.848 |
MAP2K7_TYR |
0.767 | -0.155 | 2 | 0.828 |
CDK4 |
0.766 | -0.082 | 1 | 0.556 |
PINK1_TYR |
0.766 | -0.101 | 1 | 0.848 |
PKMYT1_TYR |
0.766 | -0.068 | 3 | 0.838 |
YANK3 |
0.765 | -0.072 | 2 | 0.365 |
NEK3 |
0.764 | -0.175 | 1 | 0.762 |
BUB1 |
0.763 | -0.072 | -5 | 0.666 |
PKG1 |
0.763 | -0.075 | -2 | 0.559 |
MOK |
0.762 | -0.051 | 1 | 0.667 |
EPHB4 |
0.761 | -0.002 | -1 | 0.813 |
ASK1 |
0.761 | -0.151 | 1 | 0.800 |
PBK |
0.760 | -0.117 | 1 | 0.714 |
EPHA4 |
0.760 | 0.023 | 2 | 0.731 |
ROCK1 |
0.760 | -0.043 | -3 | 0.679 |
MYO3A |
0.759 | -0.076 | 1 | 0.779 |
MST1R |
0.759 | -0.091 | 3 | 0.794 |
TYK2 |
0.758 | -0.116 | 1 | 0.828 |
RET |
0.758 | -0.119 | 1 | 0.828 |
CSF1R |
0.757 | -0.057 | 3 | 0.789 |
MYO3B |
0.757 | -0.099 | 2 | 0.807 |
INSRR |
0.756 | -0.014 | 3 | 0.754 |
FGR |
0.756 | -0.039 | 1 | 0.838 |
JAK3 |
0.755 | -0.042 | 1 | 0.822 |
TAO1 |
0.755 | -0.121 | 1 | 0.744 |
YES1 |
0.755 | -0.028 | -1 | 0.775 |
HASPIN |
0.755 | -0.116 | -1 | 0.583 |
FGFR2 |
0.755 | -0.037 | 3 | 0.810 |
BIKE |
0.755 | -0.055 | 1 | 0.679 |
DDR1 |
0.755 | -0.127 | 4 | 0.862 |
JAK2 |
0.755 | -0.116 | 1 | 0.822 |
FER |
0.754 | -0.090 | 1 | 0.875 |
TXK |
0.754 | 0.046 | 1 | 0.842 |
SRMS |
0.754 | -0.034 | 1 | 0.868 |
EPHB2 |
0.754 | 0.013 | -1 | 0.800 |
KIT |
0.754 | -0.044 | 3 | 0.805 |
CK1A |
0.754 | -0.068 | -3 | 0.406 |
EPHB1 |
0.753 | -0.034 | 1 | 0.861 |
FLT1 |
0.753 | 0.041 | -1 | 0.822 |
LIMK2_TYR |
0.753 | -0.171 | -3 | 0.831 |
FLT3 |
0.752 | -0.049 | 3 | 0.774 |
ROS1 |
0.752 | -0.141 | 3 | 0.747 |
EPHB3 |
0.752 | -0.037 | -1 | 0.798 |
ABL2 |
0.751 | -0.066 | -1 | 0.774 |
KDR |
0.750 | -0.049 | 3 | 0.761 |
LIMK1_TYR |
0.750 | -0.265 | 2 | 0.821 |
STLK3 |
0.749 | -0.186 | 1 | 0.777 |
FGFR1 |
0.749 | -0.074 | 3 | 0.772 |
HCK |
0.749 | -0.090 | -1 | 0.753 |
EPHA3 |
0.749 | -0.045 | 2 | 0.710 |
EPHA7 |
0.749 | -0.023 | 2 | 0.732 |
ERBB2 |
0.749 | -0.030 | 1 | 0.842 |
TYRO3 |
0.748 | -0.223 | 3 | 0.777 |
EGFR |
0.748 | 0.060 | 1 | 0.781 |
PDGFRB |
0.748 | -0.130 | 3 | 0.790 |
EPHA5 |
0.748 | 0.030 | 2 | 0.723 |
BLK |
0.747 | 0.008 | -1 | 0.776 |
FYN |
0.747 | 0.023 | -1 | 0.729 |
MET |
0.747 | -0.052 | 3 | 0.776 |
FGFR3 |
0.746 | -0.044 | 3 | 0.789 |
LCK |
0.746 | -0.049 | -1 | 0.755 |
ABL1 |
0.746 | -0.098 | -1 | 0.761 |
NTRK1 |
0.745 | -0.109 | -1 | 0.796 |
JAK1 |
0.745 | -0.057 | 1 | 0.788 |
FLT4 |
0.745 | -0.056 | 3 | 0.771 |
TNNI3K_TYR |
0.745 | -0.041 | 1 | 0.801 |
FRK |
0.744 | -0.020 | -1 | 0.781 |
NEK10_TYR |
0.744 | -0.109 | 1 | 0.699 |
EPHA8 |
0.743 | -0.000 | -1 | 0.781 |
TEK |
0.743 | -0.153 | 3 | 0.750 |
ITK |
0.743 | -0.117 | -1 | 0.720 |
TEC |
0.742 | -0.087 | -1 | 0.671 |
NTRK2 |
0.742 | -0.119 | 3 | 0.762 |
PDGFRA |
0.741 | -0.178 | 3 | 0.790 |
SYK |
0.741 | 0.062 | -1 | 0.753 |
FGFR4 |
0.741 | -0.009 | -1 | 0.764 |
LTK |
0.741 | -0.126 | 3 | 0.759 |
NTRK3 |
0.741 | -0.077 | -1 | 0.755 |
LYN |
0.740 | -0.053 | 3 | 0.734 |
ALK |
0.740 | -0.135 | 3 | 0.731 |
TNK2 |
0.740 | -0.160 | 3 | 0.762 |
AXL |
0.739 | -0.184 | 3 | 0.775 |
PTK2 |
0.739 | 0.023 | -1 | 0.736 |
CK1G3 |
0.739 | -0.059 | -3 | 0.360 |
MERTK |
0.738 | -0.161 | 3 | 0.771 |
PTK2B |
0.738 | -0.052 | -1 | 0.707 |
BMX |
0.738 | -0.100 | -1 | 0.654 |
SRC |
0.738 | -0.035 | -1 | 0.740 |
INSR |
0.737 | -0.128 | 3 | 0.724 |
WEE1_TYR |
0.737 | -0.136 | -1 | 0.680 |
CSK |
0.737 | -0.085 | 2 | 0.731 |
DDR2 |
0.736 | -0.042 | 3 | 0.765 |
BTK |
0.736 | -0.229 | -1 | 0.676 |
ERBB4 |
0.735 | 0.047 | 1 | 0.796 |
PTK6 |
0.735 | -0.221 | -1 | 0.660 |
EPHA2 |
0.735 | -0.010 | -1 | 0.756 |
MATK |
0.735 | -0.101 | -1 | 0.725 |
AAK1 |
0.734 | -0.024 | 1 | 0.557 |
EPHA1 |
0.734 | -0.159 | 3 | 0.755 |
YANK2 |
0.734 | -0.093 | 2 | 0.382 |
TNK1 |
0.730 | -0.247 | 3 | 0.757 |
CK1G2 |
0.728 | -0.043 | -3 | 0.456 |
MUSK |
0.728 | -0.062 | 1 | 0.760 |
IGF1R |
0.727 | -0.104 | 3 | 0.686 |
FES |
0.711 | -0.140 | -1 | 0.639 |
ZAP70 |
0.707 | -0.029 | -1 | 0.662 |