Motif 790 (n=146)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| L7N2F9 | None | S80 | ochoa | V-SNARE coiled-coil homology domain-containing protein | None |
| O00151 | PDLIM1 | S187 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O14672 | ADAM10 | S436 | psp | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:11786905, PubMed:12475894, PubMed:20592283, PubMed:24990881, PubMed:26686862, PubMed:28600292, PubMed:31792032). Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:26686862, PubMed:28600292, PubMed:31792032, PubMed:34739841, PubMed:37516108). Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:11786905, PubMed:26686862, PubMed:29224781, PubMed:34739841). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (PubMed:28600292). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28600292, ECO:0000269|PubMed:29224781, ECO:0000269|PubMed:31792032, ECO:0000269|PubMed:34739841, ECO:0000269|PubMed:37516108}.; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:30463011}. |
| O14745 | NHERF1 | S339 | psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O14980 | XPO1 | S183 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O43707 | ACTN4 | S606 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43852 | CALU | S277 | ochoa | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| O60934 | NBN | S278 | psp | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75161 | NPHP4 | S868 | ochoa | Nephrocystin-4 (Nephroretinin) | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}. |
| O75396 | SEC22B | S168 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O94913 | PCF11 | S395 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94916 | NFAT5 | S238 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O95470 | SGPL1 | S124 | ochoa | Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). {ECO:0000250|UniProtKB:Q8R0X7, ECO:0000250|UniProtKB:Q9V7Y2, ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}. |
| P00558 | PGK1 | S175 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P00973 | OAS1 | S50 | ochoa | 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34145065, PubMed:34581622). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:12799444, ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:23319625, ECO:0000269|PubMed:34145065, ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p46]: When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target (PubMed:34581622). The same mechanism is necessary to initiate a block to cardiovirus EMCV (PubMed:34581622). {ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p42]: Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}. |
| P02545 | LMNA | S107 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05814 | CSN2 | S24 | psp | Beta-casein | Important role in determination of the surface properties of the casein micelles. |
| P10768 | ESD | S210 | ochoa | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) | Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269|PubMed:3770744, ECO:0000269|PubMed:4768551}. |
| P12883 | MYH7 | S1718 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13535 | MYH8 | S563 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15036 | ETS2 | S319 | ochoa|psp | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P15336 | ATF2 | S367 | psp | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P22234 | PAICS | S223 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P24534 | EEF1B2 | S141 | ochoa | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
| P28066 | PSMA5 | S180 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P35579 | MYH9 | S39 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P38432 | COIL | S447 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P40227 | CCT6A | S94 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P40925 | MDH1 | S189 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P43686 | PSMC4 | S28 | ochoa | 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}. |
| P46782 | RPS5 | S52 | ochoa | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P46940 | IQGAP1 | S932 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49146 | NPY2R | S351 | ochoa | Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. |
| P49792 | RANBP2 | S1648 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P54132 | BLM | S646 | ochoa|psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54132 | BLM | S1195 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54278 | PMS2 | S603 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P61981 | YWHAG | S155 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P63027 | VAMP2 | S80 | ochoa | Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}. |
| P83731 | RPL24 | S86 | ochoa | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q00341 | HDLBP | S583 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00872 | MYBPC1 | S550 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q03164 | KMT2A | S279 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q12830 | BPTF | S817 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12913 | PTPRJ | S1009 | ochoa | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}. |
| Q13137 | CALCOCO2 | S238 | ochoa | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}. |
| Q13148 | TARDBP | S92 | ochoa|psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13277 | STX3 | S110 | ochoa | Syntaxin-3 | Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. {ECO:0000269|PubMed:24726755}.; FUNCTION: [Isoform B]: Essential for survival of retinal photoreceetors. {ECO:0000269|PubMed:33974130}.; FUNCTION: [Isoform 3]: Functions as a regulator of gene expression. {ECO:0000269|PubMed:29475951}. |
| Q13427 | PPIG | S717 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13561 | DCTN2 | S70 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q13596 | SNX1 | S172 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q14789 | GOLGB1 | S2735 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15058 | KIF14 | S21 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15836 | VAMP3 | S63 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q15911 | ZFHX3 | S1202 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q19T08 | ECSCR | S165 | ochoa | Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2) | Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}. |
| Q2NKX8 | ERCC6L | S829 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q58EX2 | SDK2 | S1972 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5T8P6 | RBM26 | S795 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5UIP0 | RIF1 | S1873 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q641Q2 | WASHC2A | S890 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q66K89 | E4F1 | S216 | ochoa | Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F) | May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes. |
| Q6IPM2 | IQCE | S320 | ochoa | IQ domain-containing protein E | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}. |
| Q6P4F7 | ARHGAP11A | S335 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P4F7 | ARHGAP11A | S340 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PKG0 | LARP1 | S700 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6U841 | SLC4A10 | S238 | ochoa | Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) | Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q5DTL9, ECO:0000250|UniProtKB:Q80ZA5, ECO:0000269|PubMed:18319254}. |
| Q6WCQ1 | MPRIP | S381 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZU80 | CEP128 | S855 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q7L2Z9 | CENPQ | S139 | psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q7L4I2 | RSRC2 | S384 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7L590 | MCM10 | S435 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7LG56 | RRM2B | S72 | psp | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}. |
| Q7Z2E3 | APTX | S182 | ochoa | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15044383, PubMed:15380105, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:16547001, ECO:0000269|PubMed:16964241, ECO:0000269|PubMed:17276982, ECO:0000269|PubMed:24362567}. |
| Q7Z3E2 | CCDC186 | S98 | ochoa | Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) | None |
| Q86X02 | CDR2L | S344 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q8IWC1 | MAP7D3 | S461 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IYL3 | C1orf174 | S47 | ochoa | UPF0688 protein C1orf174 | None |
| Q8N392 | ARHGAP18 | S610 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8N6H7 | ARFGAP2 | S238 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N7H5 | PAF1 | S117 | ochoa | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}. |
| Q8N8Z6 | DCBLD1 | S513 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NB49 | ATP11C | S445 | ochoa | Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24904167, PubMed:25315773, PubMed:26567335, PubMed:32493773). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250|UniProtKB:Q9QZW0, ECO:0000269|PubMed:24904167, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:26944472, ECO:0000269|PubMed:32493773}. |
| Q8NG08 | HELB | S709 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8NG31 | KNL1 | S767 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NI35 | PATJ | S806 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8WWI1 | LMO7 | S295 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXI7 | MUC16 | S12481 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q92539 | LPIN2 | S151 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92556 | ELMO1 | S342 | ochoa | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}. |
| Q92616 | GCN1 | S786 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q92692 | NECTIN2 | S405 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92854 | SEMA4D | S833 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q96AT1 | KIAA1143 | S130 | ochoa | Uncharacterized protein KIAA1143 | None |
| Q96EB6 | SIRT1 | S571 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96N46 | TTC14 | S544 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96QB1 | DLC1 | S673 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96RS6 | NUDCD1 | S388 | ochoa | NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66) | None |
| Q96S90 | LYSMD1 | S168 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q9BUB5 | MKNK1 | S39 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BW66 | CINP | S69 | ochoa | Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) | Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:16082200, PubMed:19889979). Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q9BWH2 | FUNDC2 | S151 | ochoa | FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6) | Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281). {ECO:0000269|PubMed:25855506, ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}. |
| Q9BX40 | LSM14B | S324 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9BXW9 | FANCD2 | S1257 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BZ95 | NSD3 | S909 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZD4 | NUF2 | S171 | ochoa | Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23085020}. |
| Q9GZR1 | SENP6 | S412 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9H173 | SIL1 | S147 | ochoa | Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP) | Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}. |
| Q9H3Z4 | DNAJC5 | S34 | psp | DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP) | Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250|UniProtKB:P60904, ECO:0000250|UniProtKB:Q29455}. |
| Q9HAN9 | NMNAT1 | S136 | psp | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (By similarity). {ECO:0000250|UniProtKB:Q9EPA7, ECO:0000269|PubMed:17402747, ECO:0000269|PubMed:27257257}. |
| Q9HCM1 | RESF1 | S1358 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
| Q9NXD2 | MTMR10 | S582 | ochoa | Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) | None |
| Q9NY72 | SCN3B | S196 | ochoa | Sodium channel regulatory subunit beta-3 | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:20558140, PubMed:21051419). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5 (PubMed:20558140, PubMed:21051419, PubMed:24567321, PubMed:31950564). Could also regulate the atypical sodium channel SCN7A/Nav2.1 (PubMed:35301303). Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (PubMed:14975698). {ECO:0000250|UniProtKB:Q9JK00, ECO:0000269|PubMed:14975698, ECO:0000269|PubMed:20558140, ECO:0000269|PubMed:21051419, ECO:0000269|PubMed:24567321, ECO:0000269|PubMed:31950564, ECO:0000269|PubMed:35301303}. |
| Q9NY74 | ETAA1 | S186 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZQ7 | CD274 | S195 | psp | Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:31399419, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:36727298}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
| Q9P0J1 | PDP1 | S114 | ochoa | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1) | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. {ECO:0000269|PubMed:15554715, ECO:0000305|PubMed:15855260}. |
| Q9UGN4 | CD300A | S217 | ochoa | CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a) | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}. |
| Q9UHI6 | DDX20 | S505 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UKX2 | MYH2 | S563 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX7 | NUP50 | S52 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9UQN3 | CHMP2B | S80 | ochoa | Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
| Q9Y2F5 | ICE1 | S1910 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2X9 | ZNF281 | S785 | ochoa|psp | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y4D8 | HECTD4 | S1715 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q16658 | FSCN1 | S234 | Sugiyama | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| P20618 | PSMB1 | S157 | Sugiyama | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O00410 | IPO5 | S974 | Sugiyama | Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}. |
| P07900 | HSP90AA1 | S468 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| Q13439 | GOLGA4 | S1187 | Sugiyama | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| P35251 | RFC1 | S253 | Sugiyama | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| Q8TDY2 | RB1CC1 | S943 | PSP | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| O94992 | HEXIM1 | S268 | Sugiyama | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| Q96MH2 | HEXIM2 | S194 | Sugiyama | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
| P41091 | EIF2S3 | S410 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| Q2VIR3 | EIF2S3B | S410 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}. |
| Q99832 | CCT7 | S96 | Sugiyama | T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q15398 | DLGAP5 | S67 | GPS6|EPSD | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q6PID6 | TTC33 | S19 | Sugiyama | Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor) | None |
| Q86U86 | PBRM1 | S267 | Sugiyama | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96AY3 | FKBP10 | S523 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP10 (PPIase FKBP10) (EC 5.2.1.8) (65 kDa FK506-binding protein) (65 kDa FKBP) (FKBP-65) (FK506-binding protein 10) (FKBP-10) (Immunophilin FKBP65) (Rotamase) | PPIases accelerate the folding of proteins during protein synthesis. |
| P63151 | PPP2R2A | S113 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| Q9UNH7 | SNX6 | S343 | Sugiyama | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}. |
| Q5S007 | LRRK2 | S1283 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q9P2E9 | RRBP1 | S872 | Sugiyama | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2K8 | EIF2AK4 | S467 | Sugiyama | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| Q15047 | SETDB1 | S86 | Sugiyama | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-68886 | M Phase | 6.286953e-08 | 7.202 |
| R-HSA-68882 | Mitotic Anaphase | 2.578818e-07 | 6.589 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.711546e-07 | 6.567 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.130379e-07 | 6.504 |
| R-HSA-1640170 | Cell Cycle | 7.785790e-07 | 6.109 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.119769e-06 | 5.951 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.660733e-05 | 4.575 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.980038e-05 | 4.156 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.980038e-05 | 4.156 |
| R-HSA-68877 | Mitotic Prometaphase | 9.362460e-05 | 4.029 |
| R-HSA-69481 | G2/M Checkpoints | 1.452180e-04 | 3.838 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.697892e-04 | 3.770 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.927020e-04 | 3.715 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 3.761436e-04 | 3.425 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.268991e-04 | 3.486 |
| R-HSA-69275 | G2/M Transition | 3.533633e-04 | 3.452 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.788639e-04 | 3.422 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.230995e-04 | 3.491 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.156726e-04 | 3.211 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.703941e-04 | 3.174 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.996151e-04 | 3.155 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.011899e-03 | 2.995 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 1.322239e-03 | 2.879 |
| R-HSA-2262752 | Cellular responses to stress | 1.377894e-03 | 2.861 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.501705e-03 | 2.823 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.458558e-03 | 2.836 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.681485e-03 | 2.774 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.929376e-03 | 2.715 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.366212e-03 | 2.626 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.649573e-03 | 2.577 |
| R-HSA-5357801 | Programmed Cell Death | 2.787455e-03 | 2.555 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.027292e-03 | 2.519 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.328817e-03 | 2.478 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.694297e-03 | 2.432 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.058742e-03 | 2.392 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.882693e-03 | 2.411 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.114854e-03 | 2.386 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.965878e-03 | 2.402 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.137869e-03 | 2.383 |
| R-HSA-162906 | HIV Infection | 4.853154e-03 | 2.314 |
| R-HSA-9909396 | Circadian clock | 5.005212e-03 | 2.301 |
| R-HSA-168255 | Influenza Infection | 5.213609e-03 | 2.283 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.969132e-03 | 2.304 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 8.916587e-03 | 2.050 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.969539e-03 | 2.157 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.969539e-03 | 2.157 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 8.029006e-03 | 2.095 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.089852e-02 | 1.963 |
| R-HSA-380287 | Centrosome maturation | 1.182513e-02 | 1.927 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.219529e-03 | 2.141 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 9.529687e-03 | 2.021 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.222405e-02 | 1.913 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.167297e-03 | 2.038 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.045337e-02 | 1.981 |
| R-HSA-192905 | vRNP Assembly | 9.745723e-03 | 2.011 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 7.219529e-03 | 2.141 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.033451e-02 | 1.986 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 7.761717e-03 | 2.110 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.016682e-02 | 1.993 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.016682e-02 | 1.993 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.135574e-02 | 1.945 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 9.097919e-03 | 2.041 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.016682e-02 | 1.993 |
| R-HSA-199991 | Membrane Trafficking | 1.135141e-02 | 1.945 |
| R-HSA-4641258 | Degradation of DVL | 1.151385e-02 | 1.939 |
| R-HSA-9711097 | Cellular response to starvation | 1.117117e-02 | 1.952 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.082815e-02 | 1.965 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.082815e-02 | 1.965 |
| R-HSA-4641257 | Degradation of AXIN | 1.151385e-02 | 1.939 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.151385e-02 | 1.939 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 8.916587e-03 | 2.050 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 9.529687e-03 | 2.021 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 9.529687e-03 | 2.021 |
| R-HSA-169911 | Regulation of Apoptosis | 1.016682e-02 | 1.993 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.638101e-03 | 2.178 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.045337e-02 | 1.981 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.135574e-02 | 1.945 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.002016e-02 | 1.999 |
| R-HSA-1500931 | Cell-Cell communication | 9.519133e-03 | 2.021 |
| R-HSA-109581 | Apoptosis | 1.235988e-02 | 1.908 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.371851e-02 | 1.863 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.435859e-02 | 1.843 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.295890e-02 | 1.887 |
| R-HSA-68875 | Mitotic Prophase | 1.407374e-02 | 1.852 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.371851e-02 | 1.863 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.371851e-02 | 1.863 |
| R-HSA-69541 | Stabilization of p53 | 1.295890e-02 | 1.887 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.414574e-02 | 1.849 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.450299e-02 | 1.839 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.450299e-02 | 1.839 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.450299e-02 | 1.839 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.880136e-02 | 1.726 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.973261e-02 | 1.705 |
| R-HSA-9907900 | Proteasome assembly | 1.789133e-02 | 1.747 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.973666e-02 | 1.705 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.973666e-02 | 1.705 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.531243e-02 | 1.815 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.531243e-02 | 1.815 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.661517e-02 | 1.779 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.661517e-02 | 1.779 |
| R-HSA-9675135 | Diseases of DNA repair | 1.973666e-02 | 1.705 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.531243e-02 | 1.815 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.531243e-02 | 1.815 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.734832e-02 | 1.761 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.700653e-02 | 1.769 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.789133e-02 | 1.747 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.880136e-02 | 1.726 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.880136e-02 | 1.726 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.880136e-02 | 1.726 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.880136e-02 | 1.726 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.880136e-02 | 1.726 |
| R-HSA-9824272 | Somitogenesis | 1.880136e-02 | 1.726 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.721201e-02 | 1.764 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.657906e-02 | 1.780 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 2.077240e-02 | 1.683 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 2.077240e-02 | 1.683 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.090660e-02 | 1.680 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.675643e-02 | 1.573 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.883662e-02 | 1.540 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.883662e-02 | 1.540 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.883662e-02 | 1.540 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.883662e-02 | 1.540 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.883662e-02 | 1.540 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.452857e-02 | 1.610 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.620242e-02 | 1.582 |
| R-HSA-6798695 | Neutrophil degranulation | 3.025496e-02 | 1.519 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.883662e-02 | 1.540 |
| R-HSA-373756 | SDK interactions | 2.077240e-02 | 1.683 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.699090e-02 | 1.569 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.089829e-02 | 1.510 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.890079e-02 | 1.539 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.069727e-02 | 1.684 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.588022e-02 | 1.587 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.699273e-02 | 1.569 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.168320e-02 | 1.664 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.883284e-02 | 1.540 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.588022e-02 | 1.587 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.813049e-02 | 1.551 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.373106e-02 | 1.625 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.699273e-02 | 1.569 |
| R-HSA-373753 | Nephrin family interactions | 2.883662e-02 | 1.540 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.929345e-02 | 1.533 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.048156e-02 | 1.516 |
| R-HSA-449836 | Other interleukin signaling | 2.675643e-02 | 1.573 |
| R-HSA-9766229 | Degradation of CDH1 | 2.269447e-02 | 1.644 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.479299e-02 | 1.606 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.021894e-02 | 1.520 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.479299e-02 | 1.606 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.929345e-02 | 1.533 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.699273e-02 | 1.569 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.028619e-02 | 1.519 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.479299e-02 | 1.606 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.779348e-02 | 1.556 |
| R-HSA-421270 | Cell-cell junction organization | 2.511502e-02 | 1.600 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.269447e-02 | 1.644 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.269447e-02 | 1.644 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.099717e-02 | 1.509 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.099717e-02 | 1.509 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.169477e-02 | 1.499 |
| R-HSA-1280218 | Adaptive Immune System | 3.206064e-02 | 1.494 |
| R-HSA-191859 | snRNP Assembly | 3.419619e-02 | 1.466 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.419619e-02 | 1.466 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.443881e-02 | 1.463 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.111581e-02 | 1.386 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.111581e-02 | 1.386 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.111581e-02 | 1.386 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.111581e-02 | 1.386 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.111581e-02 | 1.386 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.111581e-02 | 1.386 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.111581e-02 | 1.386 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.111581e-02 | 1.386 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.111581e-02 | 1.386 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.111581e-02 | 1.386 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.111581e-02 | 1.386 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.257886e-02 | 1.371 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.229437e-02 | 1.374 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.372961e-02 | 1.359 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.667234e-02 | 1.331 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.257886e-02 | 1.371 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.468263e-02 | 1.350 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.517588e-02 | 1.454 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.518897e-02 | 1.345 |
| R-HSA-373755 | Semaphorin interactions | 3.949677e-02 | 1.403 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.667234e-02 | 1.331 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.952420e-02 | 1.403 |
| R-HSA-9707616 | Heme signaling | 3.813464e-02 | 1.419 |
| R-HSA-69239 | Synthesis of DNA | 3.756168e-02 | 1.425 |
| R-HSA-69306 | DNA Replication | 3.517588e-02 | 1.454 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.679710e-02 | 1.434 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.813464e-02 | 1.419 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.949677e-02 | 1.403 |
| R-HSA-351202 | Metabolism of polyamines | 3.548426e-02 | 1.450 |
| R-HSA-202403 | TCR signaling | 4.052707e-02 | 1.392 |
| R-HSA-446728 | Cell junction organization | 3.882877e-02 | 1.411 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.229437e-02 | 1.374 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.756168e-02 | 1.425 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.756168e-02 | 1.425 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.679710e-02 | 1.434 |
| R-HSA-73894 | DNA Repair | 4.831305e-02 | 1.316 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.971051e-02 | 1.304 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.971051e-02 | 1.304 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.971051e-02 | 1.304 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 5.112940e-02 | 1.291 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 5.112940e-02 | 1.291 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.126503e-02 | 1.290 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.126503e-02 | 1.290 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.126503e-02 | 1.290 |
| R-HSA-5693538 | Homology Directed Repair | 5.134747e-02 | 1.289 |
| R-HSA-168256 | Immune System | 5.157280e-02 | 1.288 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 5.283590e-02 | 1.277 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.284298e-02 | 1.277 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.444420e-02 | 1.264 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.444420e-02 | 1.264 |
| R-HSA-3371556 | Cellular response to heat stress | 5.487321e-02 | 1.261 |
| R-HSA-73886 | Chromosome Maintenance | 5.487321e-02 | 1.261 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 5.552456e-02 | 1.256 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 5.552456e-02 | 1.256 |
| R-HSA-114452 | Activation of BH3-only proteins | 5.552456e-02 | 1.256 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 5.552456e-02 | 1.256 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 7.084578e-02 | 1.150 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 5.826037e-02 | 1.235 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 5.826037e-02 | 1.235 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 6.386841e-02 | 1.195 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 6.386841e-02 | 1.195 |
| R-HSA-390522 | Striated Muscle Contraction | 6.673818e-02 | 1.176 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 6.673818e-02 | 1.176 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 6.965018e-02 | 1.157 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 7.260321e-02 | 1.139 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.807175e-02 | 1.167 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 8.113746e-02 | 1.091 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 6.673818e-02 | 1.176 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 6.386841e-02 | 1.195 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 6.386841e-02 | 1.195 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 6.965018e-02 | 1.157 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.541203e-02 | 1.123 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 6.965018e-02 | 1.157 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 7.862776e-02 | 1.104 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.161862e-02 | 1.145 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 6.673818e-02 | 1.176 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 8.169701e-02 | 1.088 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 8.055070e-02 | 1.094 |
| R-HSA-1500620 | Meiosis | 7.541203e-02 | 1.123 |
| R-HSA-180746 | Nuclear import of Rev protein | 6.965018e-02 | 1.157 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 7.260321e-02 | 1.139 |
| R-HSA-5617833 | Cilium Assembly | 7.051774e-02 | 1.152 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.465242e-02 | 1.072 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.103903e-02 | 1.214 |
| R-HSA-9659379 | Sensory processing of sound | 6.453100e-02 | 1.190 |
| R-HSA-5250982 | Toxicity of tetanus toxin (tetX) | 6.103903e-02 | 1.214 |
| R-HSA-5250989 | Toxicity of botulinum toxin type G (botG) | 7.084578e-02 | 1.150 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 8.055070e-02 | 1.094 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 8.055070e-02 | 1.094 |
| R-HSA-5689603 | UCH proteinases | 5.938587e-02 | 1.226 |
| R-HSA-69206 | G1/S Transition | 6.103353e-02 | 1.214 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 7.084578e-02 | 1.150 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 6.386841e-02 | 1.195 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.159958e-02 | 1.088 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.169927e-02 | 1.144 |
| R-HSA-422475 | Axon guidance | 7.621231e-02 | 1.118 |
| R-HSA-9824446 | Viral Infection Pathways | 5.777376e-02 | 1.238 |
| R-HSA-6807070 | PTEN Regulation | 8.307900e-02 | 1.081 |
| R-HSA-5619084 | ABC transporter disorders | 6.279364e-02 | 1.202 |
| R-HSA-157118 | Signaling by NOTCH | 5.754360e-02 | 1.240 |
| R-HSA-4086400 | PCP/CE pathway | 6.279364e-02 | 1.202 |
| R-HSA-9679506 | SARS-CoV Infections | 8.327334e-02 | 1.079 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 8.480276e-02 | 1.072 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 8.480276e-02 | 1.072 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 8.480276e-02 | 1.072 |
| R-HSA-201556 | Signaling by ALK | 8.480276e-02 | 1.072 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 8.480276e-02 | 1.072 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.589335e-02 | 1.066 |
| R-HSA-1632852 | Macroautophagy | 8.607738e-02 | 1.065 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.607738e-02 | 1.065 |
| R-HSA-202424 | Downstream TCR signaling | 8.704548e-02 | 1.060 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 8.794394e-02 | 1.056 |
| R-HSA-9646399 | Aggrephagy | 8.794394e-02 | 1.056 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 8.794394e-02 | 1.056 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 8.794394e-02 | 1.056 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.912803e-02 | 1.050 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.912803e-02 | 1.050 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 9.015485e-02 | 1.045 |
| R-HSA-164944 | Nef and signal transduction | 9.015485e-02 | 1.045 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 9.015485e-02 | 1.045 |
| R-HSA-8964011 | HDL clearance | 9.015485e-02 | 1.045 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 9.015485e-02 | 1.045 |
| R-HSA-72731 | Recycling of eIF2:GDP | 9.965926e-02 | 1.001 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.457210e-01 | 0.836 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.457210e-01 | 0.836 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.546483e-01 | 0.811 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.634828e-01 | 0.787 |
| R-HSA-774815 | Nucleosome assembly | 1.074763e-01 | 0.969 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.074763e-01 | 0.969 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.108365e-01 | 0.955 |
| R-HSA-72649 | Translation initiation complex formation | 1.386278e-01 | 0.858 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.457963e-01 | 0.836 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.330146e-01 | 0.876 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.425786e-01 | 0.846 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.425786e-01 | 0.846 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.808774e-01 | 0.743 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.457210e-01 | 0.836 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.573366e-01 | 0.803 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.573366e-01 | 0.803 |
| R-HSA-69109 | Leading Strand Synthesis | 1.546483e-01 | 0.811 |
| R-HSA-69091 | Polymerase switching | 1.546483e-01 | 0.811 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.566881e-01 | 0.805 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 9.313034e-02 | 1.031 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.330146e-01 | 0.876 |
| R-HSA-391251 | Protein folding | 9.313034e-02 | 1.031 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.546483e-01 | 0.811 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.142241e-01 | 0.942 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.183730e-01 | 0.927 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.808774e-01 | 0.743 |
| R-HSA-912446 | Meiotic recombination | 1.280299e-01 | 0.893 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.808774e-01 | 0.743 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.386278e-01 | 0.858 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.530400e-01 | 0.815 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.640331e-01 | 0.785 |
| R-HSA-9612973 | Autophagy | 1.118952e-01 | 0.951 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.345275e-01 | 0.871 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.183730e-01 | 0.927 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.422023e-01 | 0.847 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.168577e-01 | 0.932 |
| R-HSA-8951664 | Neddylation | 1.112548e-01 | 0.954 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.275844e-01 | 0.894 |
| R-HSA-425381 | Bicarbonate transporters | 1.367000e-01 | 0.864 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 9.111947e-02 | 1.040 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.315408e-01 | 0.881 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.546483e-01 | 0.811 |
| R-HSA-416700 | Other semaphorin interactions | 1.808774e-01 | 0.743 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 9.432830e-02 | 1.025 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 9.965926e-02 | 1.001 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 1.090650e-01 | 0.962 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.183730e-01 | 0.927 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.183730e-01 | 0.927 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.367000e-01 | 0.864 |
| R-HSA-8983711 | OAS antiviral response | 1.546483e-01 | 0.811 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.634828e-01 | 0.787 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.808774e-01 | 0.743 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.213951e-01 | 0.916 |
| R-HSA-8953854 | Metabolism of RNA | 1.170494e-01 | 0.932 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.494508e-01 | 0.826 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.183730e-01 | 0.927 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.546483e-01 | 0.811 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.546483e-01 | 0.811 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.722255e-01 | 0.764 |
| R-HSA-2559583 | Cellular Senescence | 1.581157e-01 | 0.801 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.722255e-01 | 0.764 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.808774e-01 | 0.743 |
| R-HSA-180786 | Extension of Telomeres | 1.566881e-01 | 0.805 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.677285e-01 | 0.775 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.304725e-01 | 0.884 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.184737e-01 | 0.926 |
| R-HSA-70171 | Glycolysis | 1.123863e-01 | 0.949 |
| R-HSA-69242 | S Phase | 9.858770e-02 | 1.006 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.123863e-01 | 0.949 |
| R-HSA-4839726 | Chromatin organization | 1.543768e-01 | 0.811 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.464323e-01 | 0.834 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.523649e-01 | 0.817 |
| R-HSA-8848021 | Signaling by PTK6 | 1.714382e-01 | 0.766 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.714382e-01 | 0.766 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.367000e-01 | 0.864 |
| R-HSA-70326 | Glucose metabolism | 1.598413e-01 | 0.796 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.808774e-01 | 0.743 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.315408e-01 | 0.881 |
| R-HSA-1643685 | Disease | 1.787985e-01 | 0.748 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.640843e-01 | 0.785 |
| R-HSA-162587 | HIV Life Cycle | 1.136125e-01 | 0.945 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.084959e-01 | 0.965 |
| R-HSA-74160 | Gene expression (Transcription) | 1.410368e-01 | 0.851 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.283206e-01 | 0.892 |
| R-HSA-9675108 | Nervous system development | 1.042890e-01 | 0.982 |
| R-HSA-162582 | Signal Transduction | 1.406089e-01 | 0.852 |
| R-HSA-211000 | Gene Silencing by RNA | 1.306601e-01 | 0.884 |
| R-HSA-418990 | Adherens junctions interactions | 1.070298e-01 | 0.970 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.457963e-01 | 0.836 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.036487e-01 | 0.984 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.407231e-01 | 0.852 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 9.519691e-02 | 1.021 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.318919e-01 | 0.880 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.648872e-01 | 0.783 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.445191e-01 | 0.840 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.445191e-01 | 0.840 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.483553e-01 | 0.829 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.133979e-01 | 0.945 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 1.510885e-01 | 0.821 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.146137e-01 | 0.941 |
| R-HSA-449147 | Signaling by Interleukins | 1.435459e-01 | 0.843 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.699801e-01 | 0.770 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.824621e-01 | 0.739 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.864067e-01 | 0.730 |
| R-HSA-5663205 | Infectious disease | 1.867977e-01 | 0.729 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.889793e-01 | 0.724 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.894394e-01 | 0.723 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.894394e-01 | 0.723 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 1.894394e-01 | 0.723 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 1.894394e-01 | 0.723 |
| R-HSA-5635838 | Activation of SMO | 1.894394e-01 | 0.723 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.894394e-01 | 0.723 |
| R-HSA-5218859 | Regulated Necrosis | 1.901779e-01 | 0.721 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.908422e-01 | 0.719 |
| R-HSA-72766 | Translation | 1.959938e-01 | 0.708 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.979125e-01 | 0.704 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.979125e-01 | 0.704 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.979125e-01 | 0.704 |
| R-HSA-1474165 | Reproduction | 1.987501e-01 | 0.702 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.053599e-01 | 0.687 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.053599e-01 | 0.687 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.062975e-01 | 0.686 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.062975e-01 | 0.686 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 2.062975e-01 | 0.686 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.062975e-01 | 0.686 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.062975e-01 | 0.686 |
| R-HSA-2028269 | Signaling by Hippo | 2.062975e-01 | 0.686 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.091767e-01 | 0.679 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.125700e-01 | 0.672 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.130008e-01 | 0.672 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.145953e-01 | 0.668 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.145953e-01 | 0.668 |
| R-HSA-5358508 | Mismatch Repair | 2.145953e-01 | 0.668 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.145953e-01 | 0.668 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.145953e-01 | 0.668 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.145953e-01 | 0.668 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.168317e-01 | 0.664 |
| R-HSA-8852135 | Protein ubiquitination | 2.168317e-01 | 0.664 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.168317e-01 | 0.664 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.176316e-01 | 0.662 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.228069e-01 | 0.652 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.258369e-01 | 0.646 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.285855e-01 | 0.641 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.285855e-01 | 0.641 |
| R-HSA-9664407 | Parasite infection | 2.285855e-01 | 0.641 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.299403e-01 | 0.638 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.309331e-01 | 0.637 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.309331e-01 | 0.637 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.389749e-01 | 0.622 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.389749e-01 | 0.622 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 2.389749e-01 | 0.622 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.389749e-01 | 0.622 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.389749e-01 | 0.622 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.389749e-01 | 0.622 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.396419e-01 | 0.620 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.424205e-01 | 0.615 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.437928e-01 | 0.613 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.469331e-01 | 0.607 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.469331e-01 | 0.607 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.515271e-01 | 0.599 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.548085e-01 | 0.594 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 2.548085e-01 | 0.594 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.548085e-01 | 0.594 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.548085e-01 | 0.594 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.548085e-01 | 0.594 |
| R-HSA-9758941 | Gastrulation | 2.563900e-01 | 0.591 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.620098e-01 | 0.582 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 2.626021e-01 | 0.581 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.626021e-01 | 0.581 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.626021e-01 | 0.581 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.626021e-01 | 0.581 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.631402e-01 | 0.580 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.631402e-01 | 0.580 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.631402e-01 | 0.580 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.648258e-01 | 0.577 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.703146e-01 | 0.568 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.703146e-01 | 0.568 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.703146e-01 | 0.568 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.703146e-01 | 0.568 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.703146e-01 | 0.568 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.703146e-01 | 0.568 |
| R-HSA-156902 | Peptide chain elongation | 2.708849e-01 | 0.567 |
| R-HSA-9663891 | Selective autophagy | 2.708849e-01 | 0.567 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.779470e-01 | 0.556 |
| R-HSA-420029 | Tight junction interactions | 2.779470e-01 | 0.556 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.779470e-01 | 0.556 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.779470e-01 | 0.556 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.779470e-01 | 0.556 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.779470e-01 | 0.556 |
| R-HSA-112310 | Neurotransmitter release cycle | 2.786276e-01 | 0.555 |
| R-HSA-9610379 | HCMV Late Events | 2.789588e-01 | 0.554 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.817947e-01 | 0.550 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.824972e-01 | 0.549 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.854999e-01 | 0.544 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.854999e-01 | 0.544 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.854999e-01 | 0.544 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.854999e-01 | 0.544 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.854999e-01 | 0.544 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.854999e-01 | 0.544 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.854999e-01 | 0.544 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.854999e-01 | 0.544 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.863652e-01 | 0.543 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.863652e-01 | 0.543 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.902311e-01 | 0.537 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.929744e-01 | 0.533 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.929744e-01 | 0.533 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.929744e-01 | 0.533 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.929744e-01 | 0.533 |
| R-HSA-75109 | Triglyceride biosynthesis | 2.929744e-01 | 0.533 |
| R-HSA-1483213 | Synthesis of PE | 2.929744e-01 | 0.533 |
| R-HSA-264876 | Insulin processing | 2.929744e-01 | 0.533 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.929744e-01 | 0.533 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 2.929744e-01 | 0.533 |
| R-HSA-212436 | Generic Transcription Pathway | 2.941405e-01 | 0.531 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.003711e-01 | 0.522 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.003711e-01 | 0.522 |
| R-HSA-5620971 | Pyroptosis | 3.003711e-01 | 0.522 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.018126e-01 | 0.520 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.056665e-01 | 0.515 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.056665e-01 | 0.515 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.076908e-01 | 0.512 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.076908e-01 | 0.512 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.076908e-01 | 0.512 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.076908e-01 | 0.512 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 3.076908e-01 | 0.512 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.076908e-01 | 0.512 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.076908e-01 | 0.512 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.095165e-01 | 0.509 |
| R-HSA-157579 | Telomere Maintenance | 3.133624e-01 | 0.504 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.149345e-01 | 0.502 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.149345e-01 | 0.502 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.149345e-01 | 0.502 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.149345e-01 | 0.502 |
| R-HSA-9609646 | HCMV Infection | 3.152333e-01 | 0.501 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.172037e-01 | 0.499 |
| R-HSA-422356 | Regulation of insulin secretion | 3.172037e-01 | 0.499 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.210401e-01 | 0.493 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.221027e-01 | 0.492 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.221027e-01 | 0.492 |
| R-HSA-5688426 | Deubiquitination | 3.270443e-01 | 0.485 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.274125e-01 | 0.485 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.286971e-01 | 0.483 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.286971e-01 | 0.483 |
| R-HSA-69190 | DNA strand elongation | 3.291965e-01 | 0.483 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.291965e-01 | 0.483 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.362164e-01 | 0.473 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.362164e-01 | 0.473 |
| R-HSA-9930044 | Nuclear RNA decay | 3.362164e-01 | 0.473 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.362164e-01 | 0.473 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.362164e-01 | 0.473 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.362164e-01 | 0.473 |
| R-HSA-192823 | Viral mRNA Translation | 3.363310e-01 | 0.473 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.418619e-01 | 0.466 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.431633e-01 | 0.464 |
| R-HSA-168249 | Innate Immune System | 3.435817e-01 | 0.464 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.477333e-01 | 0.459 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.500379e-01 | 0.456 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.500379e-01 | 0.456 |
| R-HSA-203615 | eNOS activation | 3.500379e-01 | 0.456 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.500379e-01 | 0.456 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.500379e-01 | 0.456 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.500379e-01 | 0.456 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.500379e-01 | 0.456 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.552993e-01 | 0.449 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.568410e-01 | 0.448 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.568410e-01 | 0.448 |
| R-HSA-381042 | PERK regulates gene expression | 3.568410e-01 | 0.448 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.590708e-01 | 0.445 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.635733e-01 | 0.439 |
| R-HSA-3371511 | HSF1 activation | 3.635733e-01 | 0.439 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.635733e-01 | 0.439 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.702355e-01 | 0.432 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.702355e-01 | 0.432 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.702355e-01 | 0.432 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.702355e-01 | 0.432 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.740749e-01 | 0.427 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.768284e-01 | 0.424 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.768284e-01 | 0.424 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.768284e-01 | 0.424 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.833527e-01 | 0.416 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.839349e-01 | 0.416 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.852353e-01 | 0.414 |
| R-HSA-3371568 | Attenuation phase | 3.898091e-01 | 0.409 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.926281e-01 | 0.406 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.926281e-01 | 0.406 |
| R-HSA-9609690 | HCMV Early Events | 3.928281e-01 | 0.406 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.961982e-01 | 0.402 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.961982e-01 | 0.402 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.961982e-01 | 0.402 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.961982e-01 | 0.402 |
| R-HSA-9607240 | FLT3 Signaling | 3.961982e-01 | 0.402 |
| R-HSA-597592 | Post-translational protein modification | 4.012656e-01 | 0.397 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.025209e-01 | 0.395 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.025209e-01 | 0.395 |
| R-HSA-392499 | Metabolism of proteins | 4.059085e-01 | 0.392 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.075433e-01 | 0.390 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.087778e-01 | 0.389 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.124711e-01 | 0.385 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.149695e-01 | 0.382 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.149695e-01 | 0.382 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.149695e-01 | 0.382 |
| R-HSA-913531 | Interferon Signaling | 4.185187e-01 | 0.378 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.210967e-01 | 0.376 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.210967e-01 | 0.376 |
| R-HSA-69236 | G1 Phase | 4.210967e-01 | 0.376 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.216299e-01 | 0.375 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.217858e-01 | 0.375 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.239704e-01 | 0.373 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.271602e-01 | 0.369 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.271602e-01 | 0.369 |
| R-HSA-195721 | Signaling by WNT | 4.286448e-01 | 0.368 |
| R-HSA-194138 | Signaling by VEGF | 4.325369e-01 | 0.364 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.331605e-01 | 0.363 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.331605e-01 | 0.363 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.331605e-01 | 0.363 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.331605e-01 | 0.363 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.331605e-01 | 0.363 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.331605e-01 | 0.363 |
| R-HSA-75153 | Apoptotic execution phase | 4.331605e-01 | 0.363 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.390983e-01 | 0.357 |
| R-HSA-1483191 | Synthesis of PC | 4.390983e-01 | 0.357 |
| R-HSA-114608 | Platelet degranulation | 4.396453e-01 | 0.357 |
| R-HSA-397014 | Muscle contraction | 4.401813e-01 | 0.356 |
| R-HSA-5620924 | Intraflagellar transport | 4.449743e-01 | 0.352 |
| R-HSA-70263 | Gluconeogenesis | 4.449743e-01 | 0.352 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.449743e-01 | 0.352 |
| R-HSA-73893 | DNA Damage Bypass | 4.507891e-01 | 0.346 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.622376e-01 | 0.335 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.641364e-01 | 0.333 |
| R-HSA-72187 | mRNA 3'-end processing | 4.678726e-01 | 0.330 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.678726e-01 | 0.330 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.678726e-01 | 0.330 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.678726e-01 | 0.330 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.734489e-01 | 0.325 |
| R-HSA-1221632 | Meiotic synapsis | 4.734489e-01 | 0.325 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.734489e-01 | 0.325 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.778486e-01 | 0.321 |
| R-HSA-163685 | Integration of energy metabolism | 4.778486e-01 | 0.321 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.812434e-01 | 0.318 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 4.860847e-01 | 0.313 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.898316e-01 | 0.310 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.898316e-01 | 0.310 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.898316e-01 | 0.310 |
| R-HSA-177929 | Signaling by EGFR | 4.898316e-01 | 0.310 |
| R-HSA-5621480 | Dectin-2 family | 4.951791e-01 | 0.305 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.976597e-01 | 0.303 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.004709e-01 | 0.301 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.004709e-01 | 0.301 |
| R-HSA-9033241 | Peroxisomal protein import | 5.057075e-01 | 0.296 |
| R-HSA-8979227 | Triglyceride metabolism | 5.057075e-01 | 0.296 |
| R-HSA-8939211 | ESR-mediated signaling | 5.070642e-01 | 0.295 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.108895e-01 | 0.292 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.108895e-01 | 0.292 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.108895e-01 | 0.292 |
| R-HSA-156590 | Glutathione conjugation | 5.108895e-01 | 0.292 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.108895e-01 | 0.292 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.108895e-01 | 0.292 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.108895e-01 | 0.292 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.108895e-01 | 0.292 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.108895e-01 | 0.292 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.160176e-01 | 0.287 |
| R-HSA-450294 | MAP kinase activation | 5.160176e-01 | 0.287 |
| R-HSA-1442490 | Collagen degradation | 5.160176e-01 | 0.287 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.210922e-01 | 0.283 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.210922e-01 | 0.283 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.273195e-01 | 0.278 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.282051e-01 | 0.277 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.310832e-01 | 0.275 |
| R-HSA-9609507 | Protein localization | 5.368300e-01 | 0.270 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.399710e-01 | 0.268 |
| R-HSA-196807 | Nicotinate metabolism | 5.456826e-01 | 0.263 |
| R-HSA-913709 | O-linked glycosylation of mucins | 5.504479e-01 | 0.259 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.504479e-01 | 0.259 |
| R-HSA-877300 | Interferon gamma signaling | 5.554561e-01 | 0.255 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.585089e-01 | 0.253 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.598300e-01 | 0.252 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.598300e-01 | 0.252 |
| R-HSA-448424 | Interleukin-17 signaling | 5.598300e-01 | 0.252 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.598300e-01 | 0.252 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 5.644478e-01 | 0.248 |
| R-HSA-8978934 | Metabolism of cofactors | 5.644478e-01 | 0.248 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 5.690174e-01 | 0.245 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.690174e-01 | 0.245 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.705713e-01 | 0.244 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.780142e-01 | 0.238 |
| R-HSA-5619102 | SLC transporter disorders | 5.794616e-01 | 0.237 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.838940e-01 | 0.234 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.868242e-01 | 0.231 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.911060e-01 | 0.228 |
| R-HSA-72306 | tRNA processing | 5.911060e-01 | 0.228 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.954514e-01 | 0.225 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.038995e-01 | 0.219 |
| R-HSA-9833482 | PKR-mediated signaling | 6.038995e-01 | 0.219 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.038995e-01 | 0.219 |
| R-HSA-6806834 | Signaling by MET | 6.038995e-01 | 0.219 |
| R-HSA-977225 | Amyloid fiber formation | 6.080576e-01 | 0.216 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.080576e-01 | 0.216 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.137869e-01 | 0.212 |
| R-HSA-9658195 | Leishmania infection | 6.137869e-01 | 0.212 |
| R-HSA-70268 | Pyruvate metabolism | 6.359738e-01 | 0.197 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.397970e-01 | 0.194 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.405404e-01 | 0.193 |
| R-HSA-73884 | Base Excision Repair | 6.473242e-01 | 0.189 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.583227e-01 | 0.182 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.689802e-01 | 0.175 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.793071e-01 | 0.168 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.826778e-01 | 0.166 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.826778e-01 | 0.166 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.826778e-01 | 0.166 |
| R-HSA-190236 | Signaling by FGFR | 6.826778e-01 | 0.166 |
| R-HSA-3214847 | HATs acetylate histones | 6.860132e-01 | 0.164 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.958118e-01 | 0.158 |
| R-HSA-1483255 | PI Metabolism | 6.958118e-01 | 0.158 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.002594e-01 | 0.155 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.021747e-01 | 0.154 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.084053e-01 | 0.150 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.175090e-01 | 0.144 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.204803e-01 | 0.142 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.234206e-01 | 0.141 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.234206e-01 | 0.141 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.320582e-01 | 0.135 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.348774e-01 | 0.134 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.395791e-01 | 0.131 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.404276e-01 | 0.131 |
| R-HSA-72312 | rRNA processing | 7.435666e-01 | 0.129 |
| R-HSA-373760 | L1CAM interactions | 7.458623e-01 | 0.127 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.485371e-01 | 0.126 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.485371e-01 | 0.126 |
| R-HSA-15869 | Metabolism of nucleotides | 7.513857e-01 | 0.124 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.538030e-01 | 0.123 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.538030e-01 | 0.123 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.589592e-01 | 0.120 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.614969e-01 | 0.118 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.614969e-01 | 0.118 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.682684e-01 | 0.114 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 7.697959e-01 | 0.114 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.713850e-01 | 0.113 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.713850e-01 | 0.113 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.713850e-01 | 0.113 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.785326e-01 | 0.109 |
| R-HSA-5576891 | Cardiac conduction | 7.877182e-01 | 0.104 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.899549e-01 | 0.102 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.989896e-01 | 0.097 |
| R-HSA-5173105 | O-linked glycosylation | 8.028910e-01 | 0.095 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.041142e-01 | 0.095 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.080339e-01 | 0.093 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.159655e-01 | 0.088 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.264348e-01 | 0.083 |
| R-HSA-166520 | Signaling by NTRKs | 8.264348e-01 | 0.083 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.300773e-01 | 0.081 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.300773e-01 | 0.081 |
| R-HSA-1266738 | Developmental Biology | 8.352878e-01 | 0.078 |
| R-HSA-1483257 | Phospholipid metabolism | 8.448679e-01 | 0.073 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.471809e-01 | 0.072 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.682880e-01 | 0.061 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.682880e-01 | 0.061 |
| R-HSA-611105 | Respiratory electron transport | 8.751015e-01 | 0.058 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.770234e-01 | 0.057 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.787403e-01 | 0.056 |
| R-HSA-3781865 | Diseases of glycosylation | 8.828166e-01 | 0.054 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.852816e-01 | 0.053 |
| R-HSA-983712 | Ion channel transport | 8.888826e-01 | 0.051 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.912207e-01 | 0.050 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.943424e-01 | 0.048 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.946364e-01 | 0.048 |
| R-HSA-428157 | Sphingolipid metabolism | 9.021974e-01 | 0.045 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.042568e-01 | 0.044 |
| R-HSA-72172 | mRNA Splicing | 9.062731e-01 | 0.043 |
| R-HSA-382551 | Transport of small molecules | 9.064251e-01 | 0.043 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.354481e-01 | 0.029 |
| R-HSA-112316 | Neuronal System | 9.656847e-01 | 0.015 |
| R-HSA-8957322 | Metabolism of steroids | 9.739927e-01 | 0.011 |
| R-HSA-1474244 | Extracellular matrix organization | 9.758740e-01 | 0.011 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.878752e-01 | 0.005 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.882609e-01 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 9.894603e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.915058e-01 | 0.004 |
| R-HSA-211859 | Biological oxidations | 9.969963e-01 | 0.001 |
| R-HSA-109582 | Hemostasis | 9.982965e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.985356e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.997489e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.998077e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998744e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.999233e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999374e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.876 | 0.207 | 2 | 0.864 |
DSTYK |
0.862 | 0.120 | 2 | 0.875 |
CLK3 |
0.856 | 0.150 | 1 | 0.802 |
PRPK |
0.856 | -0.087 | -1 | 0.857 |
ATR |
0.856 | 0.188 | 1 | 0.903 |
NEK6 |
0.856 | 0.095 | -2 | 0.890 |
CDC7 |
0.855 | -0.038 | 1 | 0.810 |
MOS |
0.855 | 0.067 | 1 | 0.831 |
GCN2 |
0.854 | -0.081 | 2 | 0.746 |
ULK2 |
0.854 | -0.034 | 2 | 0.749 |
RAF1 |
0.854 | -0.048 | 1 | 0.825 |
MST4 |
0.853 | 0.123 | 2 | 0.874 |
IKKB |
0.853 | -0.080 | -2 | 0.780 |
TGFBR2 |
0.853 | 0.108 | -2 | 0.836 |
MLK1 |
0.853 | 0.091 | 2 | 0.819 |
NEK7 |
0.853 | 0.028 | -3 | 0.842 |
PRKD1 |
0.853 | 0.135 | -3 | 0.829 |
CDKL1 |
0.852 | 0.076 | -3 | 0.810 |
BMPR2 |
0.852 | 0.002 | -2 | 0.904 |
NLK |
0.852 | 0.034 | 1 | 0.784 |
NUAK2 |
0.852 | 0.095 | -3 | 0.837 |
RIPK3 |
0.851 | 0.054 | 3 | 0.813 |
PIM3 |
0.851 | 0.019 | -3 | 0.824 |
PKN3 |
0.850 | 0.056 | -3 | 0.838 |
MTOR |
0.850 | -0.123 | 1 | 0.775 |
PRKD2 |
0.849 | 0.120 | -3 | 0.778 |
CAMK1B |
0.849 | 0.002 | -3 | 0.870 |
TBK1 |
0.849 | -0.101 | 1 | 0.734 |
ERK5 |
0.849 | 0.048 | 1 | 0.781 |
PDHK4 |
0.848 | -0.273 | 1 | 0.839 |
WNK1 |
0.848 | 0.038 | -2 | 0.855 |
CDKL5 |
0.848 | 0.087 | -3 | 0.805 |
ATM |
0.847 | 0.200 | 1 | 0.868 |
NIK |
0.847 | 0.046 | -3 | 0.884 |
CHAK2 |
0.847 | 0.034 | -1 | 0.835 |
PDHK1 |
0.847 | -0.172 | 1 | 0.834 |
PKCD |
0.846 | 0.112 | 2 | 0.799 |
IKKE |
0.846 | -0.115 | 1 | 0.728 |
PKN2 |
0.845 | 0.069 | -3 | 0.839 |
MLK3 |
0.845 | 0.143 | 2 | 0.761 |
CAMK2G |
0.844 | -0.117 | 2 | 0.742 |
TSSK2 |
0.844 | 0.116 | -5 | 0.885 |
SRPK1 |
0.844 | 0.090 | -3 | 0.756 |
AMPKA1 |
0.843 | 0.037 | -3 | 0.852 |
MARK4 |
0.843 | -0.004 | 4 | 0.830 |
NEK9 |
0.843 | -0.019 | 2 | 0.822 |
NUAK1 |
0.843 | 0.081 | -3 | 0.799 |
SKMLCK |
0.843 | 0.018 | -2 | 0.820 |
TSSK1 |
0.842 | 0.102 | -3 | 0.870 |
ULK1 |
0.842 | -0.111 | -3 | 0.850 |
MLK2 |
0.842 | 0.016 | 2 | 0.809 |
NDR2 |
0.842 | -0.073 | -3 | 0.827 |
MAPKAPK3 |
0.841 | 0.026 | -3 | 0.783 |
IRE2 |
0.841 | 0.091 | 2 | 0.751 |
CAMLCK |
0.841 | -0.023 | -2 | 0.830 |
IKKA |
0.841 | -0.055 | -2 | 0.771 |
WNK3 |
0.840 | -0.139 | 1 | 0.827 |
ANKRD3 |
0.840 | 0.015 | 1 | 0.850 |
IRE1 |
0.839 | 0.026 | 1 | 0.804 |
DAPK2 |
0.839 | -0.015 | -3 | 0.873 |
PIM1 |
0.839 | 0.054 | -3 | 0.772 |
PRKD3 |
0.838 | 0.104 | -3 | 0.757 |
AMPKA2 |
0.838 | 0.033 | -3 | 0.820 |
HUNK |
0.838 | -0.114 | 2 | 0.763 |
SRPK2 |
0.838 | 0.087 | -3 | 0.679 |
NDR1 |
0.837 | -0.068 | -3 | 0.827 |
RSK2 |
0.837 | -0.003 | -3 | 0.773 |
SMG1 |
0.837 | 0.167 | 1 | 0.882 |
FAM20C |
0.837 | 0.050 | 2 | 0.579 |
HIPK4 |
0.837 | -0.015 | 1 | 0.756 |
CAMK2D |
0.836 | -0.058 | -3 | 0.853 |
PKR |
0.836 | 0.085 | 1 | 0.838 |
KIS |
0.836 | -0.016 | 1 | 0.640 |
QIK |
0.835 | 0.005 | -3 | 0.841 |
PKCB |
0.835 | 0.096 | 2 | 0.766 |
NIM1 |
0.835 | -0.050 | 3 | 0.791 |
BCKDK |
0.835 | -0.178 | -1 | 0.792 |
P90RSK |
0.835 | -0.022 | -3 | 0.781 |
PKCA |
0.835 | 0.090 | 2 | 0.757 |
MELK |
0.835 | 0.033 | -3 | 0.814 |
RSK3 |
0.834 | -0.028 | -3 | 0.772 |
GRK5 |
0.834 | -0.214 | -3 | 0.837 |
ICK |
0.834 | -0.004 | -3 | 0.842 |
YSK4 |
0.834 | -0.006 | 1 | 0.767 |
BMPR1B |
0.833 | 0.098 | 1 | 0.739 |
SIK |
0.833 | 0.039 | -3 | 0.768 |
MAPKAPK2 |
0.833 | 0.022 | -3 | 0.728 |
MLK4 |
0.833 | 0.039 | 2 | 0.720 |
MASTL |
0.832 | -0.261 | -2 | 0.835 |
PHKG1 |
0.832 | 0.018 | -3 | 0.820 |
DLK |
0.832 | -0.154 | 1 | 0.819 |
GRK1 |
0.832 | -0.025 | -2 | 0.766 |
CHK1 |
0.832 | 0.084 | -3 | 0.823 |
RIPK1 |
0.832 | -0.152 | 1 | 0.820 |
LATS2 |
0.832 | -0.068 | -5 | 0.723 |
PKCG |
0.832 | 0.052 | 2 | 0.754 |
QSK |
0.832 | 0.017 | 4 | 0.817 |
NEK2 |
0.832 | -0.019 | 2 | 0.796 |
ALK4 |
0.832 | 0.033 | -2 | 0.865 |
DNAPK |
0.831 | 0.162 | 1 | 0.817 |
SRPK3 |
0.831 | 0.071 | -3 | 0.728 |
GRK6 |
0.831 | -0.130 | 1 | 0.805 |
TGFBR1 |
0.831 | 0.051 | -2 | 0.839 |
P70S6KB |
0.830 | -0.050 | -3 | 0.804 |
CDK8 |
0.830 | -0.043 | 1 | 0.610 |
CHAK1 |
0.830 | -0.007 | 2 | 0.740 |
ACVR2A |
0.830 | 0.073 | -2 | 0.841 |
PLK1 |
0.830 | -0.038 | -2 | 0.853 |
ACVR2B |
0.830 | 0.078 | -2 | 0.848 |
CAMK4 |
0.829 | -0.067 | -3 | 0.820 |
PKCH |
0.829 | 0.040 | 2 | 0.736 |
PKCZ |
0.829 | 0.020 | 2 | 0.778 |
MNK2 |
0.829 | -0.002 | -2 | 0.760 |
HRI |
0.828 | 0.020 | -2 | 0.887 |
CDK5 |
0.828 | 0.047 | 1 | 0.632 |
LATS1 |
0.828 | -0.005 | -3 | 0.834 |
PKACG |
0.827 | -0.070 | -2 | 0.696 |
CAMK2B |
0.827 | -0.029 | 2 | 0.716 |
CLK1 |
0.826 | 0.064 | -3 | 0.752 |
CDK1 |
0.826 | 0.039 | 1 | 0.560 |
AURC |
0.826 | -0.013 | -2 | 0.598 |
MARK2 |
0.826 | 0.001 | 4 | 0.749 |
CDK2 |
0.825 | 0.055 | 1 | 0.644 |
PERK |
0.825 | -0.001 | -2 | 0.872 |
CDK19 |
0.825 | -0.042 | 1 | 0.569 |
MEK1 |
0.825 | -0.169 | 2 | 0.778 |
VRK2 |
0.824 | -0.170 | 1 | 0.861 |
PAK6 |
0.824 | -0.006 | -2 | 0.682 |
NEK5 |
0.824 | 0.054 | 1 | 0.850 |
ALK2 |
0.824 | 0.045 | -2 | 0.839 |
CLK4 |
0.824 | 0.022 | -3 | 0.766 |
MYLK4 |
0.823 | -0.014 | -2 | 0.725 |
TTBK2 |
0.823 | -0.222 | 2 | 0.648 |
GRK4 |
0.823 | -0.200 | -2 | 0.817 |
MARK3 |
0.823 | -0.011 | 4 | 0.776 |
PAK3 |
0.823 | -0.107 | -2 | 0.754 |
PAK1 |
0.823 | -0.084 | -2 | 0.746 |
CDK7 |
0.822 | -0.061 | 1 | 0.612 |
IRAK4 |
0.822 | 0.002 | 1 | 0.827 |
BRSK2 |
0.822 | -0.067 | -3 | 0.825 |
MSK2 |
0.822 | -0.069 | -3 | 0.739 |
CAMK2A |
0.822 | -0.048 | 2 | 0.726 |
TLK2 |
0.821 | -0.036 | 1 | 0.824 |
BRAF |
0.821 | -0.050 | -4 | 0.818 |
AURB |
0.821 | -0.024 | -2 | 0.601 |
MST3 |
0.821 | 0.073 | 2 | 0.851 |
MNK1 |
0.820 | -0.012 | -2 | 0.764 |
MEKK1 |
0.820 | -0.077 | 1 | 0.815 |
SNRK |
0.820 | -0.143 | 2 | 0.626 |
DYRK2 |
0.820 | -0.040 | 1 | 0.639 |
BRSK1 |
0.820 | -0.064 | -3 | 0.797 |
CDK13 |
0.820 | -0.046 | 1 | 0.586 |
CDK18 |
0.820 | -0.002 | 1 | 0.541 |
ZAK |
0.820 | -0.058 | 1 | 0.787 |
MEKK2 |
0.819 | -0.009 | 2 | 0.778 |
CAMK1G |
0.819 | -0.006 | -3 | 0.775 |
WNK4 |
0.819 | -0.055 | -2 | 0.859 |
AKT2 |
0.819 | 0.025 | -3 | 0.694 |
P38A |
0.819 | -0.016 | 1 | 0.651 |
CDK3 |
0.819 | 0.086 | 1 | 0.499 |
PKCT |
0.819 | 0.030 | 2 | 0.746 |
MARK1 |
0.819 | -0.039 | 4 | 0.796 |
PIM2 |
0.818 | 0.013 | -3 | 0.755 |
PINK1 |
0.818 | -0.102 | 1 | 0.799 |
PKG2 |
0.818 | -0.019 | -2 | 0.622 |
PHKG2 |
0.818 | 0.004 | -3 | 0.808 |
GRK7 |
0.818 | -0.035 | 1 | 0.740 |
MAPKAPK5 |
0.817 | -0.085 | -3 | 0.730 |
BMPR1A |
0.817 | 0.076 | 1 | 0.717 |
MEKK3 |
0.817 | -0.108 | 1 | 0.784 |
JNK2 |
0.817 | -0.011 | 1 | 0.550 |
PLK3 |
0.816 | -0.120 | 2 | 0.696 |
DRAK1 |
0.816 | -0.093 | 1 | 0.725 |
ERK1 |
0.816 | -0.019 | 1 | 0.567 |
MEK5 |
0.816 | -0.170 | 2 | 0.788 |
PLK4 |
0.816 | -0.116 | 2 | 0.555 |
RSK4 |
0.816 | -0.036 | -3 | 0.736 |
TAO3 |
0.816 | 0.021 | 1 | 0.781 |
EEF2K |
0.816 | 0.158 | 3 | 0.876 |
PAK2 |
0.816 | -0.122 | -2 | 0.735 |
JNK3 |
0.815 | -0.038 | 1 | 0.592 |
CLK2 |
0.815 | 0.071 | -3 | 0.748 |
P38B |
0.815 | -0.011 | 1 | 0.580 |
NEK8 |
0.815 | -0.003 | 2 | 0.809 |
SGK3 |
0.815 | -0.032 | -3 | 0.760 |
MSK1 |
0.815 | -0.050 | -3 | 0.750 |
SMMLCK |
0.815 | -0.012 | -3 | 0.830 |
ERK2 |
0.815 | -0.044 | 1 | 0.622 |
SSTK |
0.814 | -0.003 | 4 | 0.801 |
CDK17 |
0.813 | -0.025 | 1 | 0.479 |
TAO2 |
0.813 | 0.034 | 2 | 0.848 |
DCAMKL1 |
0.813 | -0.036 | -3 | 0.779 |
PKCI |
0.813 | 0.022 | 2 | 0.751 |
PRP4 |
0.813 | -0.011 | -3 | 0.762 |
PKACB |
0.812 | -0.024 | -2 | 0.622 |
MST2 |
0.812 | 0.055 | 1 | 0.790 |
TLK1 |
0.811 | -0.075 | -2 | 0.849 |
TNIK |
0.811 | 0.131 | 3 | 0.886 |
ERK7 |
0.811 | 0.038 | 2 | 0.557 |
CDK12 |
0.811 | -0.053 | 1 | 0.558 |
PKCE |
0.811 | 0.083 | 2 | 0.748 |
DCAMKL2 |
0.811 | -0.038 | -3 | 0.813 |
IRAK1 |
0.810 | -0.155 | -1 | 0.767 |
AKT1 |
0.810 | 0.021 | -3 | 0.708 |
HIPK1 |
0.810 | -0.017 | 1 | 0.660 |
HGK |
0.810 | 0.083 | 3 | 0.884 |
CAMKK1 |
0.810 | -0.097 | -2 | 0.775 |
MPSK1 |
0.809 | -0.008 | 1 | 0.768 |
MINK |
0.809 | 0.079 | 1 | 0.789 |
CDK14 |
0.809 | -0.010 | 1 | 0.584 |
P38G |
0.809 | -0.034 | 1 | 0.473 |
CDK16 |
0.809 | 0.024 | 1 | 0.503 |
NEK4 |
0.809 | -0.015 | 1 | 0.804 |
GAK |
0.809 | 0.026 | 1 | 0.822 |
CDK9 |
0.809 | -0.088 | 1 | 0.595 |
BUB1 |
0.808 | 0.191 | -5 | 0.851 |
NEK11 |
0.808 | -0.106 | 1 | 0.780 |
AURA |
0.808 | -0.064 | -2 | 0.571 |
DYRK1A |
0.808 | -0.036 | 1 | 0.684 |
PKN1 |
0.808 | 0.035 | -3 | 0.736 |
HIPK3 |
0.808 | -0.036 | 1 | 0.656 |
P38D |
0.807 | -0.005 | 1 | 0.519 |
GRK2 |
0.807 | -0.132 | -2 | 0.706 |
TAK1 |
0.807 | 0.045 | 1 | 0.825 |
PRKX |
0.806 | -0.003 | -3 | 0.664 |
NEK1 |
0.806 | 0.030 | 1 | 0.817 |
GCK |
0.805 | 0.020 | 1 | 0.772 |
CAMK1D |
0.805 | 0.005 | -3 | 0.691 |
PASK |
0.805 | -0.074 | -3 | 0.832 |
HIPK2 |
0.805 | -0.024 | 1 | 0.545 |
CDK10 |
0.804 | 0.012 | 1 | 0.568 |
MST1 |
0.804 | 0.049 | 1 | 0.779 |
P70S6K |
0.804 | -0.074 | -3 | 0.721 |
MEKK6 |
0.804 | -0.039 | 1 | 0.813 |
LOK |
0.803 | 0.007 | -2 | 0.788 |
CHK2 |
0.803 | 0.044 | -3 | 0.639 |
PDK1 |
0.803 | -0.103 | 1 | 0.784 |
TTBK1 |
0.802 | -0.192 | 2 | 0.566 |
CAMKK2 |
0.802 | -0.149 | -2 | 0.770 |
LKB1 |
0.802 | -0.117 | -3 | 0.843 |
DAPK3 |
0.802 | -0.001 | -3 | 0.796 |
MAP3K15 |
0.801 | -0.072 | 1 | 0.772 |
LRRK2 |
0.801 | -0.063 | 2 | 0.818 |
PAK5 |
0.801 | -0.072 | -2 | 0.611 |
CDK6 |
0.801 | 0.016 | 1 | 0.566 |
GSK3B |
0.801 | -0.077 | 4 | 0.384 |
KHS1 |
0.800 | 0.065 | 1 | 0.771 |
PKACA |
0.800 | -0.031 | -2 | 0.567 |
HPK1 |
0.800 | 0.005 | 1 | 0.759 |
YSK1 |
0.799 | 0.008 | 2 | 0.813 |
KHS2 |
0.799 | 0.094 | 1 | 0.777 |
CAMK1A |
0.798 | 0.039 | -3 | 0.662 |
CK1E |
0.798 | -0.118 | -3 | 0.462 |
DYRK3 |
0.797 | -0.050 | 1 | 0.662 |
VRK1 |
0.797 | -0.097 | 2 | 0.823 |
SLK |
0.797 | -0.032 | -2 | 0.736 |
TTK |
0.796 | 0.133 | -2 | 0.849 |
DYRK4 |
0.796 | -0.053 | 1 | 0.556 |
PAK4 |
0.796 | -0.073 | -2 | 0.611 |
DYRK1B |
0.795 | -0.067 | 1 | 0.580 |
RIPK2 |
0.795 | -0.176 | 1 | 0.732 |
GSK3A |
0.795 | -0.068 | 4 | 0.394 |
AKT3 |
0.795 | 0.011 | -3 | 0.624 |
CDK4 |
0.794 | -0.022 | 1 | 0.546 |
MRCKB |
0.793 | -0.012 | -3 | 0.749 |
NEK3 |
0.793 | -0.078 | 1 | 0.776 |
CK2A2 |
0.792 | -0.044 | 1 | 0.634 |
DAPK1 |
0.791 | -0.047 | -3 | 0.779 |
MEK2 |
0.791 | -0.210 | 2 | 0.753 |
ROCK2 |
0.791 | -0.009 | -3 | 0.782 |
MYO3B |
0.790 | 0.079 | 2 | 0.823 |
MRCKA |
0.790 | -0.034 | -3 | 0.756 |
CK1D |
0.789 | -0.119 | -3 | 0.415 |
GRK3 |
0.789 | -0.138 | -2 | 0.655 |
JNK1 |
0.789 | -0.073 | 1 | 0.534 |
PLK2 |
0.789 | -0.090 | -3 | 0.747 |
SBK |
0.789 | 0.012 | -3 | 0.579 |
PBK |
0.789 | -0.034 | 1 | 0.749 |
MAK |
0.789 | 0.034 | -2 | 0.715 |
MOK |
0.788 | 0.013 | 1 | 0.691 |
STK33 |
0.788 | -0.169 | 2 | 0.556 |
MYO3A |
0.788 | 0.076 | 1 | 0.778 |
SGK1 |
0.787 | -0.020 | -3 | 0.608 |
OSR1 |
0.787 | -0.001 | 2 | 0.773 |
CK1G1 |
0.786 | -0.173 | -3 | 0.463 |
PDHK3_TYR |
0.786 | 0.034 | 4 | 0.864 |
CK1A2 |
0.785 | -0.126 | -3 | 0.413 |
HASPIN |
0.785 | 0.000 | -1 | 0.664 |
BIKE |
0.784 | 0.046 | 1 | 0.703 |
TAO1 |
0.783 | -0.009 | 1 | 0.723 |
DMPK1 |
0.783 | 0.010 | -3 | 0.758 |
CK2A1 |
0.780 | -0.067 | 1 | 0.610 |
PKG1 |
0.780 | -0.061 | -2 | 0.545 |
TESK1_TYR |
0.780 | -0.055 | 3 | 0.866 |
PKMYT1_TYR |
0.779 | -0.059 | 3 | 0.854 |
ROCK1 |
0.778 | -0.021 | -3 | 0.755 |
BMPR2_TYR |
0.778 | 0.042 | -1 | 0.903 |
ASK1 |
0.778 | -0.124 | 1 | 0.761 |
TYK2 |
0.777 | 0.030 | 1 | 0.818 |
EPHA6 |
0.777 | 0.107 | -1 | 0.886 |
PINK1_TYR |
0.776 | -0.069 | 1 | 0.825 |
MAP2K4_TYR |
0.776 | -0.151 | -1 | 0.873 |
PDHK4_TYR |
0.776 | -0.046 | 2 | 0.836 |
LIMK2_TYR |
0.776 | -0.006 | -3 | 0.898 |
CRIK |
0.775 | -0.026 | -3 | 0.706 |
ROS1 |
0.775 | 0.043 | 3 | 0.803 |
MAP2K6_TYR |
0.775 | -0.099 | -1 | 0.888 |
MAP2K7_TYR |
0.774 | -0.239 | 2 | 0.812 |
JAK2 |
0.774 | 0.021 | 1 | 0.817 |
LCK |
0.774 | 0.187 | -1 | 0.864 |
TYRO3 |
0.773 | 0.005 | 3 | 0.822 |
MST1R |
0.773 | -0.013 | 3 | 0.834 |
PDHK1_TYR |
0.772 | -0.088 | -1 | 0.895 |
ALPHAK3 |
0.772 | -0.079 | -1 | 0.789 |
CSF1R |
0.772 | 0.018 | 3 | 0.833 |
HCK |
0.771 | 0.113 | -1 | 0.860 |
BLK |
0.771 | 0.188 | -1 | 0.862 |
EPHB4 |
0.771 | 0.033 | -1 | 0.862 |
ABL2 |
0.770 | 0.049 | -1 | 0.805 |
RET |
0.770 | -0.099 | 1 | 0.815 |
LIMK1_TYR |
0.770 | -0.125 | 2 | 0.821 |
AAK1 |
0.768 | 0.077 | 1 | 0.600 |
TXK |
0.768 | 0.099 | 1 | 0.789 |
JAK3 |
0.768 | 0.008 | 1 | 0.799 |
JAK1 |
0.768 | 0.064 | 1 | 0.758 |
TNK2 |
0.767 | 0.035 | 3 | 0.781 |
ITK |
0.766 | 0.053 | -1 | 0.835 |
FLT3 |
0.766 | -0.003 | 3 | 0.828 |
YES1 |
0.766 | -0.004 | -1 | 0.838 |
TNNI3K_TYR |
0.765 | 0.056 | 1 | 0.822 |
INSRR |
0.765 | -0.019 | 3 | 0.772 |
FGR |
0.764 | -0.044 | 1 | 0.837 |
ABL1 |
0.764 | -0.002 | -1 | 0.791 |
FER |
0.764 | -0.059 | 1 | 0.853 |
KDR |
0.764 | 0.012 | 3 | 0.808 |
EPHB1 |
0.763 | 0.010 | 1 | 0.824 |
DDR1 |
0.763 | -0.164 | 4 | 0.764 |
PDGFRB |
0.763 | -0.068 | 3 | 0.837 |
STLK3 |
0.763 | -0.192 | 1 | 0.747 |
EPHA4 |
0.762 | -0.014 | 2 | 0.711 |
KIT |
0.762 | -0.038 | 3 | 0.831 |
EPHB3 |
0.762 | 0.012 | -1 | 0.849 |
SRMS |
0.762 | -0.022 | 1 | 0.824 |
NEK10_TYR |
0.761 | -0.064 | 1 | 0.702 |
TEC |
0.760 | 0.030 | -1 | 0.752 |
EPHB2 |
0.760 | 0.008 | -1 | 0.844 |
TEK |
0.759 | -0.065 | 3 | 0.765 |
TNK1 |
0.759 | -0.068 | 3 | 0.802 |
LYN |
0.759 | 0.070 | 3 | 0.773 |
PDGFRA |
0.759 | -0.082 | 3 | 0.841 |
BMX |
0.759 | 0.030 | -1 | 0.765 |
BTK |
0.758 | -0.051 | -1 | 0.787 |
WEE1_TYR |
0.758 | -0.007 | -1 | 0.762 |
FYN |
0.758 | 0.098 | -1 | 0.849 |
FRK |
0.757 | 0.040 | -1 | 0.857 |
YANK3 |
0.757 | -0.151 | 2 | 0.354 |
AXL |
0.757 | -0.068 | 3 | 0.795 |
MERTK |
0.756 | -0.032 | 3 | 0.787 |
FGFR2 |
0.756 | -0.135 | 3 | 0.801 |
FGFR1 |
0.755 | -0.128 | 3 | 0.781 |
ALK |
0.755 | -0.082 | 3 | 0.749 |
MET |
0.754 | -0.056 | 3 | 0.802 |
EPHA7 |
0.754 | -0.006 | 2 | 0.713 |
LTK |
0.752 | -0.078 | 3 | 0.770 |
FLT1 |
0.752 | -0.051 | -1 | 0.856 |
NTRK2 |
0.752 | -0.099 | 3 | 0.791 |
EPHA1 |
0.751 | -0.031 | 3 | 0.789 |
NTRK1 |
0.750 | -0.147 | -1 | 0.819 |
EPHA3 |
0.750 | -0.081 | 2 | 0.683 |
PTK6 |
0.750 | -0.156 | -1 | 0.734 |
FLT4 |
0.750 | -0.098 | 3 | 0.791 |
INSR |
0.749 | -0.107 | 3 | 0.754 |
ERBB2 |
0.748 | -0.118 | 1 | 0.756 |
NTRK3 |
0.746 | -0.097 | -1 | 0.773 |
FGFR3 |
0.745 | -0.133 | 3 | 0.783 |
EPHA5 |
0.745 | -0.030 | 2 | 0.692 |
EPHA8 |
0.744 | -0.023 | -1 | 0.847 |
SRC |
0.744 | -0.028 | -1 | 0.818 |
CK1A |
0.743 | -0.177 | -3 | 0.318 |
DDR2 |
0.743 | -0.076 | 3 | 0.765 |
PTK2 |
0.743 | 0.057 | -1 | 0.860 |
PTK2B |
0.743 | -0.090 | -1 | 0.770 |
MUSK |
0.740 | -0.073 | 1 | 0.657 |
MATK |
0.739 | -0.127 | -1 | 0.717 |
EGFR |
0.737 | -0.094 | 1 | 0.671 |
CSK |
0.737 | -0.150 | 2 | 0.716 |
EPHA2 |
0.736 | -0.026 | -1 | 0.823 |
SYK |
0.734 | 0.006 | -1 | 0.835 |
FGFR4 |
0.734 | -0.120 | -1 | 0.772 |
IGF1R |
0.731 | -0.124 | 3 | 0.694 |
ERBB4 |
0.729 | -0.043 | 1 | 0.676 |
YANK2 |
0.725 | -0.175 | 2 | 0.367 |
CK1G3 |
0.723 | -0.176 | -3 | 0.274 |
FES |
0.716 | -0.148 | -1 | 0.722 |
ZAP70 |
0.712 | -0.058 | -1 | 0.764 |
CK1G2 |
0.708 | -0.153 | -3 | 0.374 |