Motif 789 (n=190)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L170 | C1orf226 | S198 | ochoa | Uncharacterized protein C1orf226 | None |
| A7E2V4 | ZSWIM8 | S558 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| C9J798 | RASA4B | S562 | ochoa | Ras GTPase-activating protein 4B | Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250|UniProtKB:O43374}. |
| O14983 | ATP2A1 | S362 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15151 | MDM4 | S289 | psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O15551 | CLDN3 | S199 | ochoa | Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1) | Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000269|PubMed:36008380}. |
| O43374 | RASA4 | S562 | ochoa | Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}. |
| O43493 | TGOLN2 | S224 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O60237 | PPP1R12B | S393 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60841 | EIF5B | S767 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75363 | BCAS1 | S314 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75962 | TRIO | S1809 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O95810 | CAVIN2 | S247 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| O95866 | MPIG6B | S208 | ochoa | Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b) | Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). {ECO:0000269|PubMed:12665801, ECO:0000269|PubMed:17311996, ECO:0000269|PubMed:27743390}.; FUNCTION: Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. {ECO:0000305|PubMed:11544253}. |
| P01189 | POMC | S168 | psp | Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] | [Corticotropin]: Stimulates the adrenal glands to release cortisol.; FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.; FUNCTION: [Met-enkephalin]: Endogenous opiate. |
| P04818 | TYMS | S114 | ochoa|psp | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}. |
| P08133 | ANXA6 | S630 | ochoa | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P08235 | NR3C2 | S936 | psp | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}. |
| P08833 | IGFBP1 | S199 | psp | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}. |
| P09429 | HMGB1 | S39 | ochoa|psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P09960 | LTA4H | S240 | ochoa | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}. |
| P11142 | HSPA8 | S541 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11274 | BCR | S993 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P12882 | MYH1 | S1261 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1630 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1632 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P16284 | PECAM1 | S661 | ochoa | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P16615 | ATP2A2 | S362 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P16989 | YBX3 | S134 | ochoa|psp | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17026 | ZNF22 | S42 | ochoa | Zinc finger protein 22 (Zinc finger protein KOX15) (Zinc finger protein Krox-26) | Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). {ECO:0000250}. |
| P20929 | NEB | S1104 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P20929 | NEB | S1348 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P20929 | NEB | S2324 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P21127 | CDK11B | S434 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P25705 | ATP5F1A | S513 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P26641 | EEF1G | S304 | ochoa | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| P27540 | ARNT | S68 | ochoa | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}. |
| P31327 | CPS1 | S468 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31327 | CPS1 | S537 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31948 | STIP1 | S42 | ochoa | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P33527 | ABCC1 | S289 | ochoa | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}. |
| P35579 | MYH9 | S1114 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35659 | DEK | S71 | ochoa | Protein DEK | Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
| P35749 | MYH11 | S1121 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P42574 | CASP3 | S29 | ochoa | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}. |
| P42685 | FRK | S220 | ochoa | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P42766 | RPL35 | S29 | ochoa | Large ribosomal subunit protein uL29 (60S ribosomal protein L35) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P46821 | MAP1B | S541 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46939 | UTRN | S1695 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P48730 | CSNK1D | S53 | psp | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49321 | NASP | S662 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49736 | MCM2 | S878 | ochoa | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49790 | NUP153 | S687 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51003 | PAPOLA | S672 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51948 | MNAT1 | S224 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P55196 | AFDN | S1265 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P67809 | YBX1 | S102 | ochoa|psp | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P98170 | XIAP | S406 | ochoa | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11257230, PubMed:11257231, PubMed:11447297, PubMed:12121969, PubMed:12620238, PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:9230442). Acts as a direct caspase inhibitor (PubMed:11257230, PubMed:11257231, PubMed:12620238). Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, PubMed:11257231, PubMed:16352606, PubMed:16916640). Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238). Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:22607974, PubMed:29452636, PubMed:30026309). Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:19667203, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (PubMed:22607974, PubMed:29452636). Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (PubMed:17560374). Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (PubMed:20154138). Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (PubMed:17967870, PubMed:22103349). Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (PubMed:14685266). Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (PubMed:21145488). Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (PubMed:29020630). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (PubMed:22095281). Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (PubMed:22095281). Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (PubMed:22304967). Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (PubMed:22304967). {ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11447297, ECO:0000269|PubMed:12121969, ECO:0000269|PubMed:12620238, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17560374, ECO:0000269|PubMed:17967870, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:19667203, ECO:0000269|PubMed:20154138, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:22103349, ECO:0000269|PubMed:22304967, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:29020630, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:9230442, ECO:0000303|PubMed:22095281}. |
| Q01484 | ANK2 | S34 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S3042 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01804 | OTUD4 | S1006 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q02156 | PRKCE | S234 | psp | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q02880 | TOP2B | S1449 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q02952 | AKAP12 | S248 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05682 | CALD1 | S129 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q05682 | CALD1 | S628 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q09666 | AHNAK | S1571 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5577 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12830 | BPTF | S1131 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q13136 | PPFIA1 | S77 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13422 | IKZF1 | S296 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13427 | PPIG | S677 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13449 | LSAMP | S204 | ochoa | Limbic system-associated membrane protein (LSAMP) (IgLON family member 3) | Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity). {ECO:0000250}. |
| Q13492 | PICALM | S359 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13557 | CAMK2D | S333 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q14244 | MAP7 | S663 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14498 | RBM39 | S121 | ochoa | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q14562 | DHX8 | S129 | ochoa | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. |
| Q14677 | CLINT1 | S217 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q15361 | TTF1 | S710 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15375 | EPHA7 | S951 | ochoa | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
| Q15398 | DLGAP5 | S687 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q16206 | ENOX2 | S504 | psp | Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] | May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}. |
| Q16236 | NFE2L2 | S558 | psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
| Q16825 | PTPN21 | S863 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q3T8J9 | GON4L | S346 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q3V6T2 | CCDC88A | S1417 | ochoa|psp | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q5FWF5 | ESCO1 | S24 | ochoa | N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}. |
| Q5JRX3 | PITRM1 | S261 | ochoa | Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1) | Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469, PubMed:26697887). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469, PubMed:29383861, PubMed:29764912). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). It is also able to degrade amyloid-beta protein 42 (PubMed:29764912). {ECO:0000269|PubMed:10360838, ECO:0000269|PubMed:16849325, ECO:0000269|PubMed:19196155, ECO:0000269|PubMed:24931469, ECO:0000269|PubMed:26697887, ECO:0000269|PubMed:29383861, ECO:0000269|PubMed:29764912}. |
| Q5JSH3 | WDR44 | S71 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5SW79 | CEP170 | S832 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T5P2 | KIAA1217 | S809 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TCZ1 | SH3PXD2A | S748 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5THJ4 | VPS13D | S663 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S1663 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VUA4 | ZNF318 | S1238 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q641Q2 | WASHC2A | S836 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q676U5 | ATG16L1 | S70 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q6AI08 | HEATR6 | S499 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6P9G4 | TMEM154 | S117 | ochoa | Transmembrane protein 154 | None |
| Q6P9H4 | CNKSR3 | S44 | ochoa | Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) | Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}. |
| Q6UB99 | ANKRD11 | S379 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q7Z4H7 | HAUS6 | S856 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q86UE4 | MTDH | S258 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86V15 | CASZ1 | S151 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86W50 | METTL16 | S419 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IVL1 | NAV2 | S1059 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IWT6 | LRRC8A | S199 | ochoa | Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1) | Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:30095067). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:33171122). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (PubMed:33171122). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:31270356, PubMed:33139539). Acts as a key factor in NLRP3 inflammasome activation by modulating itaconate efflux and mitochondria function (PubMed:39909992). {ECO:0000250|UniProtKB:Q80WG5, ECO:0000269|PubMed:14660746, ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:29371604, ECO:0000269|PubMed:29769723, ECO:0000269|PubMed:30095067, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:33139539, ECO:0000269|PubMed:33171122, ECO:0000269|PubMed:39909992}. |
| Q8IZH2 | XRN1 | S1625 | ochoa | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. |
| Q8N3J5 | PPM1K | S248 | ochoa | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715). {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715, ECO:0000269|PubMed:19411760, ECO:0000269|PubMed:22291014, ECO:0000269|PubMed:22589535, ECO:0000269|PubMed:23086801, ECO:0000269|PubMed:29779826}. |
| Q8N6H7 | ARFGAP2 | S237 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8N9T8 | KRI1 | S136 | ochoa | Protein KRI1 homolog | None |
| Q8ND56 | LSM14A | S347 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NEE8 | TTC16 | S430 | ochoa | Tetratricopeptide repeat protein 16 (TPR repeat protein 16) | None |
| Q8TAQ2 | SMARCC2 | S810 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TD16 | BICD2 | S331 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TDM6 | DLG5 | S725 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDY2 | RB1CC1 | S1484 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TF72 | SHROOM3 | S1726 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUM9 | SLC20A1 | S265 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q8WWI1 | LMO7 | S1449 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWK9 | CKAP2 | S614 | ochoa|psp | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q92734 | TFG | S157 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q93084 | ATP2A3 | S362 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q96BN8 | OTULIN | S76 | ochoa | Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) | Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327, PubMed:26997266, PubMed:27523608, PubMed:27559085, PubMed:28919039, PubMed:30804083, PubMed:35170849, PubMed:35587511, PubMed:38630025, PubMed:38652464). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334). {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:24726323, ECO:0000269|PubMed:24726327, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27523608, ECO:0000269|PubMed:27559085, ECO:0000269|PubMed:28919039, ECO:0000269|PubMed:30804083, ECO:0000269|PubMed:35170849, ECO:0000269|PubMed:35587511, ECO:0000269|PubMed:38630025, ECO:0000269|PubMed:38652464}. |
| Q96C24 | SYTL4 | S274 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96CW1 | AP2M1 | S234 | ochoa | AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) | Component of the adaptor protein complex 2 (AP-2) (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:16581796). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (PubMed:12694563, PubMed:12952941, PubMed:14745134, PubMed:14985334, PubMed:15473838, PubMed:31104773). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (PubMed:19033387). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:11877457). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (PubMed:11877457). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P84092, ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:12694563, ECO:0000269|PubMed:12952941, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:16581796, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:31104773}. |
| Q96FA3 | PELI1 | S82 | psp | E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12496252, PubMed:17675297, PubMed:29883609, PubMed:30952868). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12496252, PubMed:17675297). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (By similarity). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination (PubMed:30952868). Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753). {ECO:0000250|UniProtKB:Q8C669, ECO:0000269|PubMed:12496252, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:33215753}. |
| Q96H79 | ZC3HAV1L | S218 | ochoa | Zinc finger CCCH-type antiviral protein 1-like | None |
| Q96IZ7 | RSRC1 | S237 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
| Q96L73 | NSD1 | S1143 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96MF7 | NSMCE2 | S116 | ochoa | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316). Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316). The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850). Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526). SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526). Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785). {ECO:0000269|PubMed:16055714, ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:31400850}. |
| Q96QB1 | DLC1 | S523 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96QT4 | TRPM7 | S1468 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RL1 | UIMC1 | S29 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96S38 | RPS6KC1 | S640 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96T58 | SPEN | S1168 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T58 | SPEN | S1206 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99848 | EBNA1BP2 | S264 | ochoa | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q9BYG5 | PARD6B | S177 | ochoa | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. |
| Q9H0K6 | PUS7L | S79 | ochoa | Pseudouridylate synthase PUS7L (EC 5.4.99.-) (Pseudouridylate synthase 7 homolog-like protein) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:35051350}. |
| Q9H2J7 | SLC6A15 | S19 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H2K8 | TAOK3 | S572 | ochoa | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
| Q9H582 | ZNF644 | S309 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H792 | PEAK1 | S1374 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HCH5 | SYTL2 | S192 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NQ84 | GPRC5C | S311 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NRY4 | ARHGAP35 | S1106 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NRZ9 | HELLS | S519 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NTI5 | PDS5B | S1407 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NVU7 | SDAD1 | S640 | ochoa | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}. |
| Q9NXG2 | THUMPD1 | S295 | ochoa | THUMP domain-containing protein 1 | Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C) (PubMed:25653167, PubMed:35196516). {ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:35196516}. |
| Q9NY74 | ETAA1 | S344 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZM5 | NOP53 | S233 | psp | Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) | Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}. |
| Q9P1Z2 | CALCOCO1 | S468 | ochoa | Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269|Ref.1}. |
| Q9P2D6 | FAM135A | S517 | ochoa | Protein FAM135A | None |
| Q9UBS8 | RNF14 | S162 | ochoa | E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (PubMed:36638793, PubMed:37651229). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (PubMed:37951215, PubMed:37951216). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326). {ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:23449499, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q9UBU9 | NXF1 | S188 | ochoa | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| Q9UEW8 | STK39 | S315 | ochoa | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UKA2 | FBXL4 | S239 | ochoa | F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) | Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors (PubMed:36896912, PubMed:38992176). Rescues also mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission (By similarity). {ECO:0000250|UniProtKB:Q8BH70, ECO:0000269|PubMed:36896912, ECO:0000269|PubMed:38992176}. |
| Q9UKA4 | AKAP11 | S1019 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKN5 | PRDM4 | S601 | ochoa | PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) | May function as a transcription factor involved in cell differentiation. |
| Q9ULJ3 | ZBTB21 | S143 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UMZ2 | SYNRG | S726 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPM8 | AP4E1 | S665 | ochoa | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UQ88 | CDK11A | S422 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2H2 | INPP5F | S827 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y2M0 | FAN1 | S116 | ochoa | Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:24981866, ECO:0000269|PubMed:25135477, ECO:0000269|PubMed:25430771}. |
| Q9Y2T7 | YBX2 | S137 | ochoa | Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog) | Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250|UniProtKB:Q9Z2C8}. |
| Q9Y3S2 | ZNF330 | S60 | ochoa | Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein) | None |
| Q9Y4E5 | ZNF451 | S438 | ochoa | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. |
| Q9Y5B6 | PAXBP1 | S155 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| O75534 | CSDE1 | S74 | Sugiyama | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| Q9UKK9 | NUDT5 | S24 | Sugiyama | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}. |
| Q4G0X9 | CCDC40 | S553 | Sugiyama | Coiled-coil domain-containing protein 40 | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131974}. |
| Q9Y3F4 | STRAP | S228 | Sugiyama | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. |
| P45985 | MAP2K4 | S55 | Sugiyama | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| Q8N6T3 | ARFGAP1 | S273 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| O15355 | PPM1G | S349 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43293 | DAPK3 | S318 | GPS6|EPSD | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
| O15226 | NKRF | S532 | Sugiyama | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| Q12802 | AKAP13 | S1253 | Sugiyama | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q9C005 | DPY30 | S50 | Sugiyama | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}. |
| Q14680 | MELK | S405 | EPSD|PSP | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q9UHB6 | LIMA1 | S283 | Sugiyama | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| P20810 | CAST | S287 | Sugiyama | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P17987 | TCP1 | S119 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| O94992 | HEXIM1 | S299 | Sugiyama | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| Q9NP61 | ARFGAP3 | S429 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9H444 | CHMP4B | S87 | Sugiyama | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:33349255}.; FUNCTION: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.000553 | 3.257 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.001050 | 2.979 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.001304 | 2.885 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.003869 | 2.412 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.003869 | 2.412 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.005011 | 2.300 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.005011 | 2.300 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.004377 | 2.359 |
| R-HSA-380287 | Centrosome maturation | 0.004844 | 2.315 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.004156 | 2.381 |
| R-HSA-5218859 | Regulated Necrosis | 0.003352 | 2.475 |
| R-HSA-397014 | Muscle contraction | 0.003602 | 2.443 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.003951 | 2.403 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.004040 | 2.394 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.006288 | 2.201 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.006183 | 2.209 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.009435 | 2.025 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.009435 | 2.025 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.010898 | 1.963 |
| R-HSA-176974 | Unwinding of DNA | 0.010898 | 1.963 |
| R-HSA-5620971 | Pyroptosis | 0.010222 | 1.990 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.007970 | 2.099 |
| R-HSA-73887 | Death Receptor Signaling | 0.007674 | 2.115 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.009235 | 2.035 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.010244 | 1.990 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.009603 | 2.018 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.011046 | 1.957 |
| R-HSA-5578775 | Ion homeostasis | 0.010126 | 1.995 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.011168 | 1.952 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.012682 | 1.897 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.013479 | 1.870 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.012682 | 1.897 |
| R-HSA-199991 | Membrane Trafficking | 0.014481 | 1.839 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.011908 | 1.924 |
| R-HSA-1640170 | Cell Cycle | 0.014893 | 1.827 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.012682 | 1.897 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.014985 | 1.824 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.015010 | 1.824 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.016602 | 1.780 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.017882 | 1.748 |
| R-HSA-69275 | G2/M Transition | 0.018450 | 1.734 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.019333 | 1.714 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.021964 | 1.658 |
| R-HSA-5579031 | Defective ACTH causes obesity and POMCD | 0.025625 | 1.591 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.026357 | 1.579 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.026571 | 1.576 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.027995 | 1.553 |
| R-HSA-5357801 | Programmed Cell Death | 0.028647 | 1.543 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.032812 | 1.484 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.032427 | 1.489 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.062843 | 1.202 |
| R-HSA-8941237 | Invadopodia formation | 0.062843 | 1.202 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.062843 | 1.202 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.074932 | 1.125 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.074932 | 1.125 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.086866 | 1.061 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.086866 | 1.061 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.098646 | 1.006 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.098646 | 1.006 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 0.110275 | 0.958 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.121755 | 0.915 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.133087 | 0.876 |
| R-HSA-196025 | Formation of annular gap junctions | 0.133087 | 0.876 |
| R-HSA-9613354 | Lipophagy | 0.144274 | 0.841 |
| R-HSA-190873 | Gap junction degradation | 0.144274 | 0.841 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.155318 | 0.809 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.048643 | 1.313 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.048643 | 1.313 |
| R-HSA-210990 | PECAM1 interactions | 0.166219 | 0.779 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.176980 | 0.752 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.198090 | 0.703 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.076494 | 1.116 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.208442 | 0.681 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.208442 | 0.681 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.218661 | 0.660 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.091901 | 1.037 |
| R-HSA-390522 | Striated Muscle Contraction | 0.095883 | 1.018 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.095883 | 1.018 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.120735 | 0.918 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.125019 | 0.903 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.066041 | 1.180 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.066041 | 1.180 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.072748 | 1.138 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.277275 | 0.557 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.277275 | 0.557 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.286609 | 0.543 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.295823 | 0.529 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.313898 | 0.503 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.313898 | 0.503 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.183437 | 0.737 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.322761 | 0.491 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.188091 | 0.726 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.133037 | 0.876 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.348674 | 0.458 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.348674 | 0.458 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.373599 | 0.428 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.381695 | 0.418 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.381695 | 0.418 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.397575 | 0.401 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.283150 | 0.548 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.145573 | 0.837 |
| R-HSA-72172 | mRNA Splicing | 0.168155 | 0.774 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.325986 | 0.487 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.042766 | 1.369 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.100327 | 0.999 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.258240 | 0.588 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.198090 | 0.703 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.080263 | 1.095 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.138923 | 0.857 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.176980 | 0.752 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.084568 | 1.073 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.397575 | 0.401 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.381695 | 0.418 |
| R-HSA-72086 | mRNA Capping | 0.365398 | 0.437 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.178521 | 0.748 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.160459 | 0.795 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.187603 | 0.727 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.187603 | 0.727 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.187603 | 0.727 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.238706 | 0.622 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.331511 | 0.480 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.331511 | 0.480 |
| R-HSA-9620244 | Long-term potentiation | 0.062027 | 1.207 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.102381 | 0.990 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.389687 | 0.409 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.144274 | 0.841 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.060156 | 1.221 |
| R-HSA-164939 | Nef mediated downregulation of CD28 cell surface expression | 0.038192 | 1.418 |
| R-HSA-420029 | Tight junction interactions | 0.062027 | 1.207 |
| R-HSA-202040 | G-protein activation | 0.286609 | 0.543 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.286609 | 0.543 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.381966 | 0.418 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.178802 | 0.748 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.121755 | 0.915 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.238706 | 0.622 |
| R-HSA-193048 | Androgen biosynthesis | 0.295823 | 0.529 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.097148 | 1.013 |
| R-HSA-75153 | Apoptotic execution phase | 0.155930 | 0.807 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.248536 | 0.605 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.397575 | 0.401 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.062843 | 1.202 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.155318 | 0.809 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.048643 | 1.313 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.176980 | 0.752 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.187603 | 0.727 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.187603 | 0.727 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.084088 | 1.075 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.258240 | 0.588 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.313898 | 0.503 |
| R-HSA-8949613 | Cristae formation | 0.348674 | 0.458 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.357090 | 0.447 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.365398 | 0.437 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.365398 | 0.437 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.381695 | 0.418 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.287840 | 0.541 |
| R-HSA-68877 | Mitotic Prometaphase | 0.296931 | 0.527 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.258240 | 0.588 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.036496 | 1.438 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.258240 | 0.588 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.355313 | 0.449 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.084568 | 1.073 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.197445 | 0.705 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.218661 | 0.660 |
| R-HSA-3371556 | Cellular response to heat stress | 0.256325 | 0.591 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.098646 | 1.006 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.228748 | 0.641 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.304919 | 0.516 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.313898 | 0.503 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.108116 | 0.966 |
| R-HSA-109581 | Apoptosis | 0.086916 | 1.061 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.155930 | 0.807 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.381695 | 0.418 |
| R-HSA-75893 | TNF signaling | 0.202143 | 0.694 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.344157 | 0.463 |
| R-HSA-9612973 | Autophagy | 0.077882 | 1.109 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.062843 | 1.202 |
| R-HSA-205025 | NADE modulates death signalling | 0.074932 | 1.125 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.176980 | 0.752 |
| R-HSA-9018681 | Biosynthesis of protectins | 0.208442 | 0.681 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.238706 | 0.622 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.258240 | 0.588 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.286609 | 0.543 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.286609 | 0.543 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.322761 | 0.491 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.357090 | 0.447 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.188835 | 0.724 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.368135 | 0.434 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.045913 | 1.338 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.165012 | 0.782 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.386548 | 0.413 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.249405 | 0.603 |
| R-HSA-1632852 | Macroautophagy | 0.056430 | 1.248 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.322761 | 0.491 |
| R-HSA-5617833 | Cilium Assembly | 0.288268 | 0.540 |
| R-HSA-8951664 | Neddylation | 0.205514 | 0.687 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.249405 | 0.603 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.259794 | 0.585 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.065548 | 1.183 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.259794 | 0.585 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.091901 | 1.037 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.045000 | 1.347 |
| R-HSA-8953854 | Metabolism of RNA | 0.224043 | 0.650 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.282514 | 0.549 |
| R-HSA-2262752 | Cellular responses to stress | 0.130739 | 0.884 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.050597 | 1.296 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.062843 | 1.202 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.074932 | 1.125 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.098646 | 1.006 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.121755 | 0.915 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 0.187603 | 0.727 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.218661 | 0.660 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.107725 | 0.968 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.183437 | 0.737 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.322761 | 0.491 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.340148 | 0.468 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.268798 | 0.571 |
| R-HSA-162587 | HIV Life Cycle | 0.396734 | 0.402 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.188091 | 0.726 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.182154 | 0.740 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.129339 | 0.888 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.091901 | 1.037 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.091901 | 1.037 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.051580 | 1.288 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.249658 | 0.603 |
| R-HSA-373760 | L1CAM interactions | 0.239082 | 0.621 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.074902 | 1.126 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.294459 | 0.531 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.151426 | 0.820 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.365277 | 0.437 |
| R-HSA-447041 | CHL1 interactions | 0.121755 | 0.915 |
| R-HSA-209952 | Peptide hormone biosynthesis | 0.155318 | 0.809 |
| R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | 0.248536 | 0.605 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.277275 | 0.557 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.357090 | 0.447 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.373599 | 0.428 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.397575 | 0.401 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.283150 | 0.548 |
| R-HSA-9018676 | Biosynthesis of D-series resolvins | 0.304919 | 0.516 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.163298 | 0.787 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.354187 | 0.451 |
| R-HSA-9663891 | Selective autophagy | 0.358849 | 0.445 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.155318 | 0.809 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.218661 | 0.660 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.228748 | 0.641 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.238706 | 0.622 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.340148 | 0.468 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.373599 | 0.428 |
| R-HSA-69481 | G2/M Checkpoints | 0.280733 | 0.552 |
| R-HSA-69206 | G1/S Transition | 0.036950 | 1.432 |
| R-HSA-69242 | S Phase | 0.066671 | 1.176 |
| R-HSA-418346 | Platelet homeostasis | 0.068960 | 1.161 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.278368 | 0.555 |
| R-HSA-8964038 | LDL clearance | 0.304919 | 0.516 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.067537 | 1.170 |
| R-HSA-422475 | Axon guidance | 0.121013 | 0.917 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.042404 | 1.373 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.072784 | 1.138 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.208442 | 0.681 |
| R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | 0.208442 | 0.681 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.091901 | 1.037 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.051580 | 1.288 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.070642 | 1.151 |
| R-HSA-3295583 | TRP channels | 0.340148 | 0.468 |
| R-HSA-1268020 | Mitochondrial protein import | 0.230565 | 0.637 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.116489 | 0.934 |
| R-HSA-9675108 | Nervous system development | 0.095705 | 1.019 |
| R-HSA-111885 | Opioid Signalling | 0.188835 | 0.724 |
| R-HSA-69190 | DNA strand elongation | 0.087968 | 1.056 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.304919 | 0.516 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.070642 | 1.151 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.208442 | 0.681 |
| R-HSA-9839394 | TGFBR3 expression | 0.331511 | 0.480 |
| R-HSA-70635 | Urea cycle | 0.340148 | 0.468 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.348674 | 0.458 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.179137 | 0.747 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.208442 | 0.681 |
| R-HSA-9018679 | Biosynthesis of EPA-derived SPMs | 0.365398 | 0.437 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.205287 | 0.688 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.166219 | 0.779 |
| R-HSA-9758890 | Transport of RCbl within the body | 0.166219 | 0.779 |
| R-HSA-8876725 | Protein methylation | 0.218661 | 0.660 |
| R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | 0.286609 | 0.543 |
| R-HSA-194002 | Glucocorticoid biosynthesis | 0.295823 | 0.529 |
| R-HSA-211976 | Endogenous sterols | 0.225806 | 0.646 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.064020 | 1.194 |
| R-HSA-111458 | Formation of apoptosome | 0.155318 | 0.809 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.146949 | 0.833 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.169582 | 0.771 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.169582 | 0.771 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.169582 | 0.771 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.208617 | 0.681 |
| R-HSA-381042 | PERK regulates gene expression | 0.103993 | 0.983 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.322761 | 0.491 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.322761 | 0.491 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.340148 | 0.468 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.330711 | 0.481 |
| R-HSA-111933 | Calmodulin induced events | 0.108116 | 0.966 |
| R-HSA-111997 | CaM pathway | 0.108116 | 0.966 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.258240 | 0.588 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.348674 | 0.458 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.222053 | 0.654 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.232242 | 0.634 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.331511 | 0.480 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.379300 | 0.421 |
| R-HSA-111996 | Ca-dependent events | 0.138082 | 0.860 |
| R-HSA-373755 | Semaphorin interactions | 0.066041 | 1.180 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.155318 | 0.809 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.304919 | 0.516 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.397575 | 0.401 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.352988 | 0.452 |
| R-HSA-2028269 | Signaling by Hippo | 0.248536 | 0.605 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.102381 | 0.990 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.058644 | 1.232 |
| R-HSA-112043 | PLC beta mediated events | 0.225806 | 0.646 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.175976 | 0.755 |
| R-HSA-5576891 | Cardiac conduction | 0.125789 | 0.900 |
| R-HSA-983712 | Ion channel transport | 0.135773 | 0.867 |
| R-HSA-449836 | Other interleukin signaling | 0.267819 | 0.572 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.397575 | 0.401 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.187590 | 0.727 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.373599 | 0.428 |
| R-HSA-162582 | Signal Transduction | 0.298033 | 0.526 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.248536 | 0.605 |
| R-HSA-112040 | G-protein mediated events | 0.254441 | 0.594 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.056269 | 1.250 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.133694 | 0.874 |
| R-HSA-157118 | Signaling by NOTCH | 0.054549 | 1.263 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.108116 | 0.966 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.258240 | 0.588 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.304919 | 0.516 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.244878 | 0.611 |
| R-HSA-449147 | Signaling by Interleukins | 0.137209 | 0.863 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.222053 | 0.654 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.349513 | 0.457 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.146493 | 0.834 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.377370 | 0.423 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.297478 | 0.527 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.354187 | 0.451 |
| R-HSA-162906 | HIV Infection | 0.399122 | 0.399 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.405363 | 0.392 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.405363 | 0.392 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.405363 | 0.392 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.405363 | 0.392 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.405363 | 0.392 |
| R-HSA-189483 | Heme degradation | 0.405363 | 0.392 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.405363 | 0.392 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.407134 | 0.390 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.409229 | 0.388 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.413050 | 0.384 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.413050 | 0.384 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.413050 | 0.384 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.413050 | 0.384 |
| R-HSA-5673000 | RAF activation | 0.413050 | 0.384 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.413050 | 0.384 |
| R-HSA-72312 | rRNA processing | 0.413650 | 0.383 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.413717 | 0.383 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.420638 | 0.376 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.420638 | 0.376 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.420638 | 0.376 |
| R-HSA-68886 | M Phase | 0.424922 | 0.372 |
| R-HSA-597592 | Post-translational protein modification | 0.426052 | 0.371 |
| R-HSA-6798695 | Neutrophil degranulation | 0.426901 | 0.370 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.427217 | 0.369 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.428129 | 0.368 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.428129 | 0.368 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.428129 | 0.368 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.431497 | 0.365 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.431497 | 0.365 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.431497 | 0.365 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.435523 | 0.361 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.435523 | 0.361 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.435523 | 0.361 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.435523 | 0.361 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.442822 | 0.354 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.442822 | 0.354 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.444772 | 0.352 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.448988 | 0.348 |
| R-HSA-69541 | Stabilization of p53 | 0.450027 | 0.347 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.450027 | 0.347 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.450027 | 0.347 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.450027 | 0.347 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.450027 | 0.347 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.450027 | 0.347 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.452118 | 0.345 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.452776 | 0.344 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.457139 | 0.340 |
| R-HSA-3371568 | Attenuation phase | 0.457139 | 0.340 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.457139 | 0.340 |
| R-HSA-9646399 | Aggrephagy | 0.457139 | 0.340 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.457139 | 0.340 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.457139 | 0.340 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.457139 | 0.340 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.457139 | 0.340 |
| R-HSA-5260271 | Diseases of Immune System | 0.457139 | 0.340 |
| R-HSA-167169 | HIV Transcription Elongation | 0.457139 | 0.340 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.457139 | 0.340 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.457139 | 0.340 |
| R-HSA-69239 | Synthesis of DNA | 0.457620 | 0.339 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.459646 | 0.338 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.461907 | 0.335 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.464160 | 0.333 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.466174 | 0.331 |
| R-HSA-421270 | Cell-cell junction organization | 0.468039 | 0.330 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.470421 | 0.328 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.470421 | 0.328 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.471091 | 0.327 |
| R-HSA-167161 | HIV Transcription Initiation | 0.471091 | 0.327 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.471091 | 0.327 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.471091 | 0.327 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.471091 | 0.327 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.471091 | 0.327 |
| R-HSA-1474244 | Extracellular matrix organization | 0.479572 | 0.319 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.484685 | 0.315 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.484685 | 0.315 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.491351 | 0.309 |
| R-HSA-190828 | Gap junction trafficking | 0.491351 | 0.309 |
| R-HSA-5683826 | Surfactant metabolism | 0.491351 | 0.309 |
| R-HSA-373752 | Netrin-1 signaling | 0.491351 | 0.309 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.491351 | 0.309 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.491351 | 0.309 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.491351 | 0.309 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.491351 | 0.309 |
| R-HSA-69236 | G1 Phase | 0.491351 | 0.309 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.491351 | 0.309 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.497932 | 0.303 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.497932 | 0.303 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.497932 | 0.303 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.503658 | 0.298 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.503658 | 0.298 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.504427 | 0.297 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.504427 | 0.297 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.504427 | 0.297 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.504427 | 0.297 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.504427 | 0.297 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.504427 | 0.297 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.504427 | 0.297 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.504427 | 0.297 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.506560 | 0.295 |
| R-HSA-437239 | Recycling pathway of L1 | 0.510839 | 0.292 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.510839 | 0.292 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.510839 | 0.292 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.513779 | 0.289 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.515116 | 0.288 |
| R-HSA-5620924 | Intraflagellar transport | 0.517169 | 0.286 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.523417 | 0.281 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.523417 | 0.281 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.523417 | 0.281 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.523740 | 0.281 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.529584 | 0.276 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.531278 | 0.275 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.531619 | 0.274 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.535525 | 0.271 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.535672 | 0.271 |
| R-HSA-72187 | mRNA 3'-end processing | 0.541682 | 0.266 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.541682 | 0.266 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.541682 | 0.266 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.541682 | 0.266 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.541682 | 0.266 |
| R-HSA-446728 | Cell junction organization | 0.541906 | 0.266 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.547614 | 0.262 |
| R-HSA-114608 | Platelet degranulation | 0.550927 | 0.259 |
| R-HSA-418597 | G alpha (z) signalling events | 0.559250 | 0.252 |
| R-HSA-9753281 | Paracetamol ADME | 0.559250 | 0.252 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.564956 | 0.248 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.564956 | 0.248 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.564956 | 0.248 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.570588 | 0.244 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.573353 | 0.242 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.576148 | 0.239 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.576148 | 0.239 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.577011 | 0.239 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.580934 | 0.236 |
| R-HSA-191859 | snRNP Assembly | 0.581636 | 0.235 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.581636 | 0.235 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.581636 | 0.235 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.581636 | 0.235 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.581636 | 0.235 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.587053 | 0.231 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.587053 | 0.231 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.587053 | 0.231 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.592401 | 0.227 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.592401 | 0.227 |
| R-HSA-450294 | MAP kinase activation | 0.592401 | 0.227 |
| R-HSA-68882 | Mitotic Anaphase | 0.592504 | 0.227 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.594958 | 0.226 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.595364 | 0.225 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.597680 | 0.224 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.597680 | 0.224 |
| R-HSA-9707616 | Heme signaling | 0.597680 | 0.224 |
| R-HSA-6807070 | PTEN Regulation | 0.601976 | 0.220 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.602890 | 0.220 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.602890 | 0.220 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.602890 | 0.220 |
| R-HSA-8848021 | Signaling by PTK6 | 0.602890 | 0.220 |
| R-HSA-211981 | Xenobiotics | 0.608034 | 0.216 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.613111 | 0.212 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.613111 | 0.212 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.620518 | 0.207 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.623070 | 0.205 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.623070 | 0.205 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.623070 | 0.205 |
| R-HSA-167172 | Transcription of the HIV genome | 0.627953 | 0.202 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.627953 | 0.202 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.627953 | 0.202 |
| R-HSA-1500931 | Cell-Cell communication | 0.636233 | 0.196 |
| R-HSA-448424 | Interleukin-17 signaling | 0.637532 | 0.195 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.637532 | 0.195 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.637532 | 0.195 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.641974 | 0.192 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.642167 | 0.192 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.642228 | 0.192 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.642228 | 0.192 |
| R-HSA-189445 | Metabolism of porphyrins | 0.642228 | 0.192 |
| R-HSA-392499 | Metabolism of proteins | 0.646031 | 0.190 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.646865 | 0.189 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.646865 | 0.189 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.646865 | 0.189 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.646865 | 0.189 |
| R-HSA-74259 | Purine catabolism | 0.646865 | 0.189 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.648547 | 0.188 |
| R-HSA-2142753 | Arachidonate metabolism | 0.648547 | 0.188 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.651441 | 0.186 |
| R-HSA-69306 | DNA Replication | 0.651704 | 0.186 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.651704 | 0.186 |
| R-HSA-9609507 | Protein localization | 0.651704 | 0.186 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.654837 | 0.184 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.655958 | 0.183 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.655958 | 0.183 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.655958 | 0.183 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.657949 | 0.182 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.660418 | 0.180 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.660418 | 0.180 |
| R-HSA-8852135 | Protein ubiquitination | 0.660418 | 0.180 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.660418 | 0.180 |
| R-HSA-9610379 | HCMV Late Events | 0.664105 | 0.178 |
| R-HSA-877300 | Interferon gamma signaling | 0.670172 | 0.174 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.673453 | 0.172 |
| R-HSA-4086400 | PCP/CE pathway | 0.673453 | 0.172 |
| R-HSA-216083 | Integrin cell surface interactions | 0.673453 | 0.172 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.677686 | 0.169 |
| R-HSA-9659379 | Sensory processing of sound | 0.677686 | 0.169 |
| R-HSA-4839726 | Chromatin organization | 0.679879 | 0.168 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.681865 | 0.166 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.681865 | 0.166 |
| R-HSA-9833482 | PKR-mediated signaling | 0.681865 | 0.166 |
| R-HSA-9609646 | HCMV Infection | 0.682298 | 0.166 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.684953 | 0.164 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.685990 | 0.164 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.685990 | 0.164 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.693560 | 0.159 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.698016 | 0.156 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.698048 | 0.156 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.698048 | 0.156 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.701964 | 0.154 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.701964 | 0.154 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.701964 | 0.154 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.703286 | 0.153 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.705830 | 0.151 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.705830 | 0.151 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.709645 | 0.149 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.710194 | 0.149 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.713411 | 0.147 |
| R-HSA-416476 | G alpha (q) signalling events | 0.714747 | 0.146 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.715569 | 0.145 |
| R-HSA-156902 | Peptide chain elongation | 0.717129 | 0.144 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.717129 | 0.144 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.718225 | 0.144 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.720799 | 0.142 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.727997 | 0.138 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.727997 | 0.138 |
| R-HSA-73894 | DNA Repair | 0.728623 | 0.137 |
| R-HSA-168255 | Influenza Infection | 0.728643 | 0.137 |
| R-HSA-2559583 | Cellular Senescence | 0.731197 | 0.136 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.731526 | 0.136 |
| R-HSA-391251 | Protein folding | 0.735010 | 0.134 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.735010 | 0.134 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.741843 | 0.130 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.745194 | 0.128 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.745194 | 0.128 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.748501 | 0.126 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.748501 | 0.126 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.748501 | 0.126 |
| R-HSA-112316 | Neuronal System | 0.762959 | 0.117 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.764407 | 0.117 |
| R-HSA-70171 | Glycolysis | 0.764407 | 0.117 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.764407 | 0.117 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.766265 | 0.116 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.767466 | 0.115 |
| R-HSA-9609690 | HCMV Early Events | 0.769353 | 0.114 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.770486 | 0.113 |
| R-HSA-1483255 | PI Metabolism | 0.770486 | 0.113 |
| R-HSA-913531 | Interferon Signaling | 0.771117 | 0.113 |
| R-HSA-192823 | Viral mRNA Translation | 0.773466 | 0.112 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.776408 | 0.110 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.776408 | 0.110 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.778128 | 0.109 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.779266 | 0.108 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.779312 | 0.108 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.779312 | 0.108 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.779312 | 0.108 |
| R-HSA-9833110 | RSV-host interactions | 0.779312 | 0.108 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.782179 | 0.107 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.784517 | 0.105 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.785008 | 0.105 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.787801 | 0.104 |
| R-HSA-211000 | Gene Silencing by RNA | 0.787801 | 0.104 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.790557 | 0.102 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.790557 | 0.102 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.790557 | 0.102 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.790557 | 0.102 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.793278 | 0.101 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.801232 | 0.096 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.801232 | 0.096 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.801232 | 0.096 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.801232 | 0.096 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.806365 | 0.093 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.806365 | 0.093 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.813817 | 0.089 |
| R-HSA-418990 | Adherens junctions interactions | 0.815937 | 0.088 |
| R-HSA-70326 | Glucose metabolism | 0.818626 | 0.087 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.818626 | 0.087 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.818626 | 0.087 |
| R-HSA-5693538 | Homology Directed Repair | 0.820984 | 0.086 |
| R-HSA-109582 | Hemostasis | 0.824342 | 0.084 |
| R-HSA-68875 | Mitotic Prophase | 0.825609 | 0.083 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.838782 | 0.076 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.838782 | 0.076 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.838782 | 0.076 |
| R-HSA-382551 | Transport of small molecules | 0.842933 | 0.074 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.844992 | 0.073 |
| R-HSA-15869 | Metabolism of nucleotides | 0.846354 | 0.072 |
| R-HSA-8956319 | Nucleotide catabolism | 0.847009 | 0.072 |
| R-HSA-9909396 | Circadian clock | 0.854818 | 0.068 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.864023 | 0.063 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.867541 | 0.062 |
| R-HSA-9679506 | SARS-CoV Infections | 0.870800 | 0.060 |
| R-HSA-9664407 | Parasite infection | 0.870968 | 0.060 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.870968 | 0.060 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.870968 | 0.060 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.872648 | 0.059 |
| R-HSA-5688426 | Deubiquitination | 0.873463 | 0.059 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.874760 | 0.058 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.875943 | 0.058 |
| R-HSA-212436 | Generic Transcription Pathway | 0.876567 | 0.057 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.877559 | 0.057 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.883507 | 0.054 |
| R-HSA-166520 | Signaling by NTRKs | 0.885329 | 0.053 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.891190 | 0.050 |
| R-HSA-1280218 | Adaptive Immune System | 0.891404 | 0.050 |
| R-HSA-168256 | Immune System | 0.893485 | 0.049 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.894007 | 0.049 |
| R-HSA-388396 | GPCR downstream signalling | 0.894654 | 0.048 |
| R-HSA-1989781 | PPARA activates gene expression | 0.895389 | 0.048 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.898098 | 0.047 |
| R-HSA-9711097 | Cellular response to starvation | 0.899427 | 0.046 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.900387 | 0.046 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.902032 | 0.045 |
| R-HSA-1266738 | Developmental Biology | 0.902560 | 0.045 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.905804 | 0.043 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.907043 | 0.042 |
| R-HSA-5619102 | SLC transporter disorders | 0.910633 | 0.041 |
| R-HSA-74160 | Gene expression (Transcription) | 0.912189 | 0.040 |
| R-HSA-72306 | tRNA processing | 0.915206 | 0.038 |
| R-HSA-418555 | G alpha (s) signalling events | 0.916312 | 0.038 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.916760 | 0.038 |
| R-HSA-418594 | G alpha (i) signalling events | 0.917791 | 0.037 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.918482 | 0.037 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.918482 | 0.037 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.918482 | 0.037 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.918482 | 0.037 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.918482 | 0.037 |
| R-HSA-195721 | Signaling by WNT | 0.919374 | 0.037 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.920596 | 0.036 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.928519 | 0.032 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.931283 | 0.031 |
| R-HSA-72766 | Translation | 0.933190 | 0.030 |
| R-HSA-9824446 | Viral Infection Pathways | 0.933982 | 0.030 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.939751 | 0.027 |
| R-HSA-168249 | Innate Immune System | 0.940336 | 0.027 |
| R-HSA-372790 | Signaling by GPCR | 0.941288 | 0.026 |
| R-HSA-428157 | Sphingolipid metabolism | 0.943587 | 0.025 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.945052 | 0.025 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.953567 | 0.021 |
| R-HSA-9748784 | Drug ADME | 0.955490 | 0.020 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.960986 | 0.017 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.962001 | 0.017 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.965351 | 0.015 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.969634 | 0.013 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.973066 | 0.012 |
| R-HSA-8978868 | Fatty acid metabolism | 0.975936 | 0.011 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.980622 | 0.008 |
| R-HSA-9658195 | Leishmania infection | 0.980622 | 0.008 |
| R-HSA-5668914 | Diseases of metabolism | 0.980818 | 0.008 |
| R-HSA-1483257 | Phospholipid metabolism | 0.983899 | 0.007 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.987593 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 0.989036 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.990125 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.991250 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.993554 | 0.003 |
| R-HSA-211859 | Biological oxidations | 0.993689 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.995230 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.995500 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.995733 | 0.002 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.997838 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.998110 | 0.001 |
| R-HSA-1643685 | Disease | 0.998592 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999688 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999987 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.892 | 0.196 | 2 | 0.890 |
CDC7 |
0.877 | 0.060 | 1 | 0.875 |
CLK3 |
0.876 | 0.208 | 1 | 0.847 |
DSTYK |
0.874 | 0.058 | 2 | 0.881 |
IKKB |
0.873 | -0.024 | -2 | 0.809 |
PRPK |
0.872 | -0.133 | -1 | 0.868 |
TSSK2 |
0.872 | 0.226 | -5 | 0.909 |
CAMK1B |
0.872 | 0.060 | -3 | 0.873 |
CAMK2G |
0.871 | -0.013 | 2 | 0.808 |
NUAK2 |
0.871 | 0.124 | -3 | 0.840 |
MOS |
0.871 | 0.046 | 1 | 0.904 |
RAF1 |
0.870 | -0.037 | 1 | 0.874 |
BMPR2 |
0.870 | 0.008 | -2 | 0.932 |
AMPKA1 |
0.870 | 0.144 | -3 | 0.856 |
PIM3 |
0.869 | 0.049 | -3 | 0.840 |
GCN2 |
0.869 | -0.135 | 2 | 0.788 |
TBK1 |
0.869 | -0.023 | 1 | 0.777 |
TSSK1 |
0.869 | 0.214 | -3 | 0.872 |
PDHK4 |
0.867 | -0.234 | 1 | 0.887 |
ULK2 |
0.867 | -0.108 | 2 | 0.790 |
NLK |
0.867 | 0.032 | 1 | 0.843 |
GRK6 |
0.867 | 0.089 | 1 | 0.858 |
IKKE |
0.866 | -0.032 | 1 | 0.779 |
MARK4 |
0.866 | 0.089 | 4 | 0.884 |
PRKD2 |
0.865 | 0.127 | -3 | 0.764 |
PRKD1 |
0.865 | 0.106 | -3 | 0.817 |
RSK2 |
0.865 | 0.072 | -3 | 0.779 |
MTOR |
0.865 | -0.149 | 1 | 0.819 |
PKN3 |
0.864 | 0.038 | -3 | 0.833 |
HUNK |
0.864 | -0.021 | 2 | 0.808 |
NIK |
0.864 | 0.025 | -3 | 0.890 |
CDKL1 |
0.864 | 0.031 | -3 | 0.816 |
TGFBR2 |
0.863 | 0.020 | -2 | 0.848 |
SRPK1 |
0.863 | 0.149 | -3 | 0.760 |
AMPKA2 |
0.863 | 0.118 | -3 | 0.822 |
WNK1 |
0.863 | 0.018 | -2 | 0.879 |
FAM20C |
0.863 | 0.133 | 2 | 0.631 |
NDR2 |
0.863 | -0.021 | -3 | 0.844 |
PDHK1 |
0.863 | -0.160 | 1 | 0.880 |
PIM1 |
0.863 | 0.108 | -3 | 0.790 |
MST4 |
0.863 | 0.058 | 2 | 0.837 |
GRK5 |
0.863 | -0.080 | -3 | 0.881 |
MLK1 |
0.863 | -0.030 | 2 | 0.806 |
NEK7 |
0.863 | -0.088 | -3 | 0.842 |
MAPKAPK3 |
0.862 | 0.065 | -3 | 0.778 |
IKKA |
0.862 | 0.022 | -2 | 0.793 |
NEK6 |
0.862 | -0.041 | -2 | 0.904 |
ATR |
0.861 | -0.076 | 1 | 0.828 |
CAMK2B |
0.861 | 0.129 | 2 | 0.786 |
CHAK2 |
0.861 | 0.011 | -1 | 0.879 |
MAPKAPK2 |
0.860 | 0.104 | -3 | 0.731 |
ERK5 |
0.860 | -0.005 | 1 | 0.797 |
GRK1 |
0.860 | 0.058 | -2 | 0.791 |
PKN2 |
0.859 | 0.036 | -3 | 0.843 |
CAMK2D |
0.859 | 0.006 | -3 | 0.844 |
NUAK1 |
0.859 | 0.099 | -3 | 0.798 |
CAMLCK |
0.858 | -0.027 | -2 | 0.862 |
BCKDK |
0.858 | -0.049 | -1 | 0.822 |
PKCD |
0.858 | 0.074 | 2 | 0.782 |
SRPK2 |
0.858 | 0.139 | -3 | 0.689 |
BMPR1B |
0.858 | 0.170 | 1 | 0.811 |
WNK3 |
0.857 | -0.144 | 1 | 0.852 |
NDR1 |
0.857 | -0.030 | -3 | 0.840 |
P90RSK |
0.857 | 0.021 | -3 | 0.782 |
SKMLCK |
0.857 | -0.014 | -2 | 0.847 |
RIPK3 |
0.857 | -0.114 | 3 | 0.716 |
ULK1 |
0.857 | -0.157 | -3 | 0.821 |
LATS2 |
0.856 | 0.004 | -5 | 0.760 |
PLK1 |
0.856 | 0.042 | -2 | 0.888 |
MELK |
0.856 | 0.067 | -3 | 0.808 |
DAPK2 |
0.855 | -0.049 | -3 | 0.877 |
P70S6KB |
0.855 | 0.009 | -3 | 0.809 |
NIM1 |
0.855 | -0.054 | 3 | 0.776 |
ALK4 |
0.854 | 0.071 | -2 | 0.879 |
ATM |
0.854 | -0.003 | 1 | 0.764 |
RSK3 |
0.854 | 0.007 | -3 | 0.778 |
NEK9 |
0.854 | -0.104 | 2 | 0.835 |
CAMK2A |
0.854 | 0.081 | 2 | 0.778 |
SRPK3 |
0.854 | 0.134 | -3 | 0.741 |
DLK |
0.854 | -0.090 | 1 | 0.858 |
QSK |
0.853 | 0.091 | 4 | 0.864 |
TGFBR1 |
0.853 | 0.093 | -2 | 0.858 |
GRK4 |
0.853 | -0.075 | -2 | 0.843 |
CDKL5 |
0.853 | 0.002 | -3 | 0.804 |
SIK |
0.853 | 0.084 | -3 | 0.772 |
PKR |
0.853 | 0.096 | 1 | 0.873 |
MARK2 |
0.852 | 0.125 | 4 | 0.817 |
PRKD3 |
0.852 | 0.090 | -3 | 0.747 |
ANKRD3 |
0.852 | -0.099 | 1 | 0.869 |
PKACG |
0.852 | 0.002 | -2 | 0.767 |
KIS |
0.852 | 0.011 | 1 | 0.695 |
IRE1 |
0.852 | -0.009 | 1 | 0.826 |
QIK |
0.851 | 0.003 | -3 | 0.839 |
PLK3 |
0.851 | 0.033 | 2 | 0.765 |
MARK3 |
0.851 | 0.115 | 4 | 0.846 |
CAMK4 |
0.851 | -0.044 | -3 | 0.825 |
IRE2 |
0.851 | 0.043 | 2 | 0.764 |
LATS1 |
0.851 | 0.071 | -3 | 0.862 |
MLK3 |
0.850 | -0.005 | 2 | 0.727 |
ALK2 |
0.850 | 0.128 | -2 | 0.861 |
HIPK4 |
0.849 | -0.021 | 1 | 0.826 |
BRSK1 |
0.849 | 0.033 | -3 | 0.799 |
RIPK1 |
0.849 | -0.165 | 1 | 0.842 |
CHK1 |
0.849 | 0.097 | -3 | 0.834 |
ACVR2A |
0.848 | 0.066 | -2 | 0.850 |
MASTL |
0.848 | -0.334 | -2 | 0.866 |
ACVR2B |
0.847 | 0.069 | -2 | 0.858 |
TTBK2 |
0.847 | -0.173 | 2 | 0.703 |
ICK |
0.847 | -0.041 | -3 | 0.840 |
MLK4 |
0.847 | -0.001 | 2 | 0.713 |
CHAK1 |
0.846 | -0.020 | 2 | 0.770 |
MLK2 |
0.846 | -0.167 | 2 | 0.814 |
GRK7 |
0.846 | 0.065 | 1 | 0.781 |
MARK1 |
0.846 | 0.080 | 4 | 0.852 |
SSTK |
0.846 | 0.133 | 4 | 0.848 |
MSK2 |
0.845 | -0.037 | -3 | 0.756 |
BMPR1A |
0.845 | 0.168 | 1 | 0.799 |
YSK4 |
0.845 | -0.066 | 1 | 0.811 |
CLK4 |
0.845 | 0.052 | -3 | 0.778 |
CLK1 |
0.844 | 0.089 | -3 | 0.748 |
PKCB |
0.844 | 0.020 | 2 | 0.727 |
SMG1 |
0.844 | -0.030 | 1 | 0.778 |
BRSK2 |
0.844 | -0.022 | -3 | 0.821 |
MNK2 |
0.844 | -0.016 | -2 | 0.813 |
MEK1 |
0.844 | -0.141 | 2 | 0.822 |
AURC |
0.844 | 0.003 | -2 | 0.653 |
CAMK1G |
0.844 | 0.040 | -3 | 0.769 |
VRK2 |
0.843 | -0.151 | 1 | 0.897 |
NEK2 |
0.843 | -0.077 | 2 | 0.804 |
CDK1 |
0.843 | 0.068 | 1 | 0.626 |
CDK8 |
0.842 | -0.035 | 1 | 0.669 |
MAPKAPK5 |
0.842 | -0.046 | -3 | 0.735 |
PKCH |
0.842 | -0.006 | 2 | 0.716 |
PHKG1 |
0.842 | -0.046 | -3 | 0.828 |
PAK1 |
0.841 | -0.072 | -2 | 0.766 |
MYLK4 |
0.841 | -0.017 | -2 | 0.774 |
PKCG |
0.841 | -0.021 | 2 | 0.726 |
CDK2 |
0.841 | 0.054 | 1 | 0.709 |
RSK4 |
0.841 | 0.032 | -3 | 0.742 |
PAK3 |
0.841 | -0.110 | -2 | 0.781 |
MSK1 |
0.840 | -0.002 | -3 | 0.762 |
PKG2 |
0.840 | 0.028 | -2 | 0.694 |
CLK2 |
0.840 | 0.140 | -3 | 0.756 |
PKCA |
0.840 | -0.003 | 2 | 0.720 |
DNAPK |
0.840 | -0.017 | 1 | 0.712 |
CDK5 |
0.839 | 0.053 | 1 | 0.685 |
TLK2 |
0.839 | -0.052 | 1 | 0.827 |
PINK1 |
0.839 | -0.057 | 1 | 0.835 |
HRI |
0.839 | -0.074 | -2 | 0.899 |
AURB |
0.839 | -0.015 | -2 | 0.653 |
DCAMKL1 |
0.839 | 0.021 | -3 | 0.785 |
CDK13 |
0.839 | 0.010 | 1 | 0.647 |
MNK1 |
0.839 | -0.012 | -2 | 0.830 |
PAK6 |
0.839 | -0.007 | -2 | 0.702 |
BRAF |
0.838 | -0.029 | -4 | 0.824 |
PKACB |
0.838 | 0.027 | -2 | 0.685 |
JNK3 |
0.838 | 0.028 | 1 | 0.657 |
DYRK2 |
0.838 | -0.007 | 1 | 0.720 |
PKCZ |
0.838 | -0.043 | 2 | 0.779 |
PERK |
0.838 | -0.086 | -2 | 0.890 |
PIM2 |
0.837 | 0.034 | -3 | 0.756 |
JNK2 |
0.837 | 0.046 | 1 | 0.615 |
PRP4 |
0.836 | 0.057 | -3 | 0.792 |
PRKX |
0.836 | 0.079 | -3 | 0.680 |
SNRK |
0.836 | -0.163 | 2 | 0.694 |
AKT2 |
0.836 | 0.029 | -3 | 0.697 |
PAK2 |
0.835 | -0.113 | -2 | 0.757 |
SGK3 |
0.835 | 0.007 | -3 | 0.772 |
CAMK1D |
0.835 | 0.069 | -3 | 0.692 |
IRAK4 |
0.835 | -0.036 | 1 | 0.835 |
GRK2 |
0.834 | -0.077 | -2 | 0.724 |
MEKK3 |
0.834 | -0.133 | 1 | 0.826 |
PLK4 |
0.833 | -0.115 | 2 | 0.644 |
AURA |
0.833 | -0.034 | -2 | 0.611 |
PHKG2 |
0.833 | -0.001 | -3 | 0.801 |
TLK1 |
0.833 | -0.067 | -2 | 0.864 |
P38A |
0.833 | -0.011 | 1 | 0.698 |
CDK7 |
0.832 | -0.065 | 1 | 0.672 |
WNK4 |
0.832 | -0.101 | -2 | 0.866 |
DRAK1 |
0.832 | -0.117 | 1 | 0.746 |
DCAMKL2 |
0.832 | -0.008 | -3 | 0.806 |
ZAK |
0.832 | -0.108 | 1 | 0.820 |
CDK19 |
0.832 | -0.051 | 1 | 0.626 |
CK2A2 |
0.832 | 0.118 | 1 | 0.734 |
MEKK1 |
0.832 | -0.134 | 1 | 0.838 |
ERK2 |
0.832 | -0.016 | 1 | 0.677 |
MEKK2 |
0.832 | -0.069 | 2 | 0.800 |
NEK5 |
0.831 | -0.084 | 1 | 0.845 |
P70S6K |
0.831 | -0.013 | -3 | 0.725 |
CDK3 |
0.831 | 0.090 | 1 | 0.559 |
CDK12 |
0.830 | 0.004 | 1 | 0.621 |
SMMLCK |
0.830 | -0.036 | -3 | 0.827 |
MST3 |
0.830 | -0.015 | 2 | 0.819 |
MEK5 |
0.830 | -0.257 | 2 | 0.814 |
TAO3 |
0.830 | -0.007 | 1 | 0.823 |
GSK3B |
0.829 | 0.002 | 4 | 0.475 |
P38B |
0.829 | 0.003 | 1 | 0.627 |
PASK |
0.829 | -0.004 | -3 | 0.851 |
CDK9 |
0.829 | -0.039 | 1 | 0.655 |
P38G |
0.828 | 0.016 | 1 | 0.539 |
PKCT |
0.828 | -0.024 | 2 | 0.730 |
CAMKK1 |
0.828 | -0.087 | -2 | 0.835 |
GSK3A |
0.828 | 0.039 | 4 | 0.487 |
ERK1 |
0.827 | -0.015 | 1 | 0.616 |
EEF2K |
0.827 | 0.114 | 3 | 0.898 |
TAO2 |
0.827 | -0.004 | 2 | 0.844 |
GAK |
0.827 | 0.002 | 1 | 0.820 |
NEK8 |
0.826 | -0.101 | 2 | 0.815 |
PKACA |
0.826 | 0.021 | -2 | 0.635 |
AKT1 |
0.826 | 0.020 | -3 | 0.710 |
HIPK1 |
0.825 | 0.000 | 1 | 0.735 |
DYRK1A |
0.825 | -0.021 | 1 | 0.753 |
IRAK1 |
0.825 | -0.199 | -1 | 0.789 |
CDK18 |
0.824 | -0.029 | 1 | 0.595 |
PKCI |
0.824 | -0.023 | 2 | 0.739 |
TTBK1 |
0.824 | -0.174 | 2 | 0.622 |
PLK2 |
0.823 | 0.042 | -3 | 0.829 |
TNIK |
0.823 | 0.107 | 3 | 0.885 |
HGK |
0.822 | 0.061 | 3 | 0.881 |
CAMK1A |
0.822 | 0.072 | -3 | 0.654 |
CK1E |
0.822 | -0.076 | -3 | 0.558 |
CHK2 |
0.822 | 0.050 | -3 | 0.639 |
HIPK2 |
0.822 | 0.003 | 1 | 0.629 |
MST2 |
0.822 | -0.010 | 1 | 0.831 |
CK2A1 |
0.821 | 0.083 | 1 | 0.713 |
CDK17 |
0.821 | -0.031 | 1 | 0.542 |
MINK |
0.821 | 0.044 | 1 | 0.828 |
PKCE |
0.821 | 0.026 | 2 | 0.710 |
P38D |
0.820 | 0.022 | 1 | 0.552 |
GRK3 |
0.820 | -0.066 | -2 | 0.667 |
CAMKK2 |
0.820 | -0.139 | -2 | 0.827 |
ERK7 |
0.820 | 0.012 | 2 | 0.538 |
GCK |
0.820 | 0.020 | 1 | 0.823 |
DAPK3 |
0.819 | -0.015 | -3 | 0.803 |
TAK1 |
0.819 | -0.033 | 1 | 0.850 |
CK1G1 |
0.819 | -0.073 | -3 | 0.565 |
PKN1 |
0.818 | -0.003 | -3 | 0.734 |
HIPK3 |
0.818 | -0.049 | 1 | 0.735 |
VRK1 |
0.818 | -0.061 | 2 | 0.867 |
PDK1 |
0.818 | -0.115 | 1 | 0.820 |
PAK5 |
0.818 | -0.068 | -2 | 0.631 |
CK1D |
0.818 | -0.054 | -3 | 0.505 |
DYRK3 |
0.817 | -0.014 | 1 | 0.746 |
DYRK1B |
0.817 | -0.021 | 1 | 0.660 |
LKB1 |
0.817 | -0.143 | -3 | 0.841 |
CDK10 |
0.817 | 0.035 | 1 | 0.621 |
DYRK4 |
0.817 | -0.014 | 1 | 0.634 |
CDK14 |
0.817 | -0.030 | 1 | 0.639 |
LOK |
0.817 | -0.011 | -2 | 0.841 |
LRRK2 |
0.817 | -0.095 | 2 | 0.842 |
MST1 |
0.816 | -0.004 | 1 | 0.823 |
NEK4 |
0.816 | -0.132 | 1 | 0.824 |
CDK16 |
0.816 | 0.005 | 1 | 0.561 |
CK1A2 |
0.815 | -0.059 | -3 | 0.505 |
MRCKA |
0.815 | 0.021 | -3 | 0.765 |
CDK6 |
0.815 | 0.053 | 1 | 0.617 |
JNK1 |
0.814 | -0.003 | 1 | 0.604 |
MRCKB |
0.814 | 0.023 | -3 | 0.747 |
NEK11 |
0.814 | -0.271 | 1 | 0.813 |
BUB1 |
0.814 | 0.121 | -5 | 0.868 |
HPK1 |
0.813 | -0.004 | 1 | 0.811 |
MPSK1 |
0.813 | -0.131 | 1 | 0.778 |
PAK4 |
0.813 | -0.070 | -2 | 0.632 |
NEK1 |
0.813 | -0.090 | 1 | 0.832 |
STK33 |
0.813 | -0.126 | 2 | 0.606 |
CDK4 |
0.813 | 0.035 | 1 | 0.610 |
KHS2 |
0.812 | 0.110 | 1 | 0.825 |
SLK |
0.812 | -0.028 | -2 | 0.777 |
DAPK1 |
0.812 | -0.042 | -3 | 0.789 |
MEKK6 |
0.811 | -0.153 | 1 | 0.829 |
SGK1 |
0.811 | 0.025 | -3 | 0.619 |
KHS1 |
0.811 | 0.059 | 1 | 0.820 |
ROCK2 |
0.810 | 0.020 | -3 | 0.793 |
MAP3K15 |
0.810 | -0.165 | 1 | 0.802 |
AKT3 |
0.810 | 0.014 | -3 | 0.629 |
SBK |
0.808 | 0.029 | -3 | 0.574 |
YSK1 |
0.808 | -0.063 | 2 | 0.800 |
RIPK2 |
0.807 | -0.252 | 1 | 0.766 |
TTK |
0.807 | 0.047 | -2 | 0.872 |
MEK2 |
0.806 | -0.236 | 2 | 0.805 |
OSR1 |
0.804 | 0.010 | 2 | 0.786 |
PDHK3_TYR |
0.804 | 0.078 | 4 | 0.882 |
DMPK1 |
0.804 | 0.037 | -3 | 0.760 |
PKG1 |
0.802 | -0.014 | -2 | 0.620 |
PBK |
0.800 | -0.111 | 1 | 0.734 |
HASPIN |
0.799 | 0.027 | -1 | 0.720 |
ROCK1 |
0.799 | 0.011 | -3 | 0.762 |
ALPHAK3 |
0.798 | -0.005 | -1 | 0.786 |
NEK3 |
0.797 | -0.188 | 1 | 0.799 |
MYO3B |
0.797 | -0.003 | 2 | 0.810 |
MYO3A |
0.796 | -0.006 | 1 | 0.830 |
MOK |
0.796 | -0.022 | 1 | 0.747 |
TESK1_TYR |
0.795 | -0.111 | 3 | 0.863 |
CRIK |
0.795 | 0.010 | -3 | 0.704 |
BIKE |
0.795 | -0.026 | 1 | 0.674 |
PDHK4_TYR |
0.795 | -0.021 | 2 | 0.869 |
MAK |
0.794 | -0.014 | -2 | 0.673 |
TAO1 |
0.794 | -0.047 | 1 | 0.767 |
MAP2K6_TYR |
0.793 | -0.092 | -1 | 0.871 |
PINK1_TYR |
0.793 | -0.103 | 1 | 0.863 |
MAP2K4_TYR |
0.793 | -0.171 | -1 | 0.874 |
BMPR2_TYR |
0.793 | -0.049 | -1 | 0.850 |
MAP2K7_TYR |
0.793 | -0.233 | 2 | 0.852 |
ASK1 |
0.790 | -0.179 | 1 | 0.792 |
EPHA6 |
0.789 | 0.010 | -1 | 0.884 |
PDHK1_TYR |
0.789 | -0.123 | -1 | 0.891 |
PKMYT1_TYR |
0.789 | -0.226 | 3 | 0.822 |
RET |
0.787 | -0.082 | 1 | 0.842 |
EPHB4 |
0.787 | 0.010 | -1 | 0.893 |
LIMK2_TYR |
0.787 | -0.092 | -3 | 0.891 |
TYRO3 |
0.787 | -0.031 | 3 | 0.773 |
TYK2 |
0.786 | -0.108 | 1 | 0.840 |
YANK3 |
0.785 | -0.110 | 2 | 0.394 |
DDR1 |
0.785 | -0.100 | 4 | 0.825 |
STLK3 |
0.785 | -0.140 | 1 | 0.786 |
YES1 |
0.785 | 0.018 | -1 | 0.880 |
ROS1 |
0.784 | -0.068 | 3 | 0.746 |
TXK |
0.784 | 0.108 | 1 | 0.836 |
LIMK1_TYR |
0.784 | -0.202 | 2 | 0.852 |
MST1R |
0.783 | -0.142 | 3 | 0.766 |
CSF1R |
0.782 | -0.063 | 3 | 0.750 |
FER |
0.782 | -0.059 | 1 | 0.876 |
ABL2 |
0.782 | -0.014 | -1 | 0.860 |
INSRR |
0.780 | -0.053 | 3 | 0.720 |
JAK2 |
0.780 | -0.150 | 1 | 0.838 |
EPHB1 |
0.780 | -0.013 | 1 | 0.856 |
FLT3 |
0.780 | -0.027 | 3 | 0.778 |
TEC |
0.779 | 0.070 | -1 | 0.820 |
HCK |
0.779 | -0.020 | -1 | 0.853 |
EPHB2 |
0.778 | 0.020 | -1 | 0.878 |
EPHA4 |
0.778 | -0.038 | 2 | 0.761 |
FGR |
0.778 | -0.108 | 1 | 0.839 |
LCK |
0.777 | 0.031 | -1 | 0.848 |
ABL1 |
0.777 | -0.045 | -1 | 0.854 |
SRMS |
0.777 | -0.046 | 1 | 0.861 |
EPHB3 |
0.777 | -0.016 | -1 | 0.888 |
AAK1 |
0.777 | 0.009 | 1 | 0.558 |
JAK3 |
0.777 | -0.130 | 1 | 0.821 |
BLK |
0.776 | 0.053 | -1 | 0.858 |
BTK |
0.776 | -0.020 | -1 | 0.827 |
ITK |
0.776 | -0.018 | -1 | 0.839 |
CK1A |
0.775 | -0.103 | -3 | 0.416 |
PDGFRB |
0.775 | -0.127 | 3 | 0.775 |
TNNI3K_TYR |
0.775 | 0.006 | 1 | 0.852 |
TEK |
0.775 | -0.105 | 3 | 0.711 |
BMX |
0.774 | 0.012 | -1 | 0.783 |
KIT |
0.774 | -0.106 | 3 | 0.757 |
WEE1_TYR |
0.774 | -0.001 | -1 | 0.795 |
FGFR2 |
0.773 | -0.152 | 3 | 0.758 |
NEK10_TYR |
0.773 | -0.086 | 1 | 0.733 |
TNK2 |
0.773 | -0.116 | 3 | 0.707 |
MERTK |
0.772 | -0.043 | 3 | 0.719 |
AXL |
0.772 | -0.097 | 3 | 0.722 |
TNK1 |
0.771 | -0.112 | 3 | 0.746 |
FGFR1 |
0.771 | -0.150 | 3 | 0.724 |
PTK6 |
0.770 | -0.125 | -1 | 0.783 |
ALK |
0.770 | -0.100 | 3 | 0.687 |
KDR |
0.770 | -0.135 | 3 | 0.719 |
JAK1 |
0.770 | -0.090 | 1 | 0.784 |
FRK |
0.769 | -0.002 | -1 | 0.883 |
CK1G3 |
0.769 | -0.048 | -3 | 0.369 |
EPHA7 |
0.769 | -0.047 | 2 | 0.766 |
LTK |
0.769 | -0.098 | 3 | 0.699 |
FYN |
0.768 | 0.004 | -1 | 0.814 |
PDGFRA |
0.768 | -0.194 | 3 | 0.775 |
DDR2 |
0.767 | -0.022 | 3 | 0.705 |
NTRK1 |
0.766 | -0.166 | -1 | 0.854 |
EPHA3 |
0.766 | -0.122 | 2 | 0.741 |
LYN |
0.765 | -0.050 | 3 | 0.694 |
ERBB2 |
0.765 | -0.159 | 1 | 0.794 |
NTRK2 |
0.764 | -0.154 | 3 | 0.716 |
MET |
0.764 | -0.148 | 3 | 0.729 |
EPHA1 |
0.764 | -0.089 | 3 | 0.708 |
EPHA5 |
0.764 | -0.028 | 2 | 0.751 |
FGFR3 |
0.763 | -0.155 | 3 | 0.730 |
INSR |
0.762 | -0.148 | 3 | 0.694 |
FLT1 |
0.762 | -0.155 | -1 | 0.835 |
MATK |
0.761 | -0.103 | -1 | 0.793 |
PTK2B |
0.761 | -0.063 | -1 | 0.846 |
FLT4 |
0.759 | -0.201 | 3 | 0.714 |
EPHA8 |
0.759 | -0.075 | -1 | 0.850 |
NTRK3 |
0.758 | -0.142 | -1 | 0.813 |
EGFR |
0.757 | -0.077 | 1 | 0.702 |
SRC |
0.757 | -0.076 | -1 | 0.828 |
FGFR4 |
0.754 | -0.093 | -1 | 0.808 |
YANK2 |
0.754 | -0.132 | 2 | 0.406 |
CSK |
0.753 | -0.152 | 2 | 0.769 |
MUSK |
0.750 | -0.120 | 1 | 0.683 |
PTK2 |
0.749 | -0.072 | -1 | 0.755 |
SYK |
0.749 | -0.051 | -1 | 0.763 |
IGF1R |
0.749 | -0.136 | 3 | 0.640 |
EPHA2 |
0.747 | -0.104 | -1 | 0.809 |
ERBB4 |
0.740 | -0.111 | 1 | 0.707 |
CK1G2 |
0.739 | -0.104 | -3 | 0.471 |
FES |
0.736 | -0.145 | -1 | 0.761 |
ZAP70 |
0.719 | -0.116 | -1 | 0.690 |