Motif 787 (n=97)

Position-wise Probabilities
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uniprot genes site source protein function
A6NKT7 RGPD3 S978 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O00139 KIF2A S586 ochoa Kinesin-like protein KIF2A (Kinesin-2) (hK2) Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}.
O14715 RGPD8 S977 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O43166 SIPA1L1 S1181 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43439 CBFA2T2 S551 ochoa Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.
O60763 USO1 S717 ochoa General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.
O75427 LRCH4 S281 ochoa Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}.
O75694 NUP155 S1057 ochoa Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.
P07237 P4HB Y99 ochoa Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}.
P0DJD0 RGPD1 S962 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S970 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P0DMV8 HSPA1A S340 ochoa Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.
P0DMV9 HSPA1B S340 ochoa Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.
P10114 RAP2A S129 ochoa Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30) Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK (PubMed:14966141, PubMed:15342639, PubMed:18930710, PubMed:20159449). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:35293963}.
P10636 MAPT S579 ochoa|psp Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11021 HSPA5 S365 ochoa Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}.
P11137 MAP2 S1679 psp Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P11137 MAP2 S1710 psp Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P11142 HSPA8 S340 ochoa Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}.
P15880 RPS2 S264 ochoa Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3) Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250|UniProtKB:P25443, ECO:0000269|PubMed:23636399}.
P16144 ITGB4 S1356 ochoa|psp Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P16298 PPP3CB S116 ochoa Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). {ECO:0000250|UniProtKB:P48453, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:32753672}.
P21796 VDAC1 S35 ochoa Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P21817 RYR1 S3566 ochoa Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}.
P27816 MAP4 S616 ochoa Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
P27816 MAP4 S941 ochoa Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
P33993 MCM7 S365 psp DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
P48454 PPP3CC S103 ochoa Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. {ECO:0000269|PubMed:19154138}.
P49116 NR2C2 S46 ochoa Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}.
P49327 FASN S2473 ochoa Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
P49792 RANBP2 S1953 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50395 GDI2 S61 ochoa Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}.
P78352 DLG4 S561 psp Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}.
Q02487 DSC2 S864 ochoa Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}.
Q04721 NOTCH2 S2070 ochoa Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}.
Q08209 PPP3CA S107 ochoa Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}.
Q12815 TROAP S156 ochoa Tastin (Trophinin-assisting protein) (Trophinin-associated protein) Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
Q12882 DPYD S587 ochoa Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). {ECO:0000269|PubMed:1512248}.
Q13136 PPFIA1 S763 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q13470 TNK1 S255 ochoa Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
Q13868 EXOSC2 S175 ochoa Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4) Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7. {ECO:0000269|PubMed:17545563}.
Q14574 DSC3 S859 ochoa Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}.
Q15717 ELAVL1 S242 psp ELAV-like protein 1 (Hu-antigen R) (HuR) RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}.
Q16831 UPP1 S61 ochoa Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:7488099). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (Probable). {ECO:0000269|PubMed:7488099, ECO:0000305|PubMed:13737038}.
Q16832 DDR2 S758 ochoa Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:30449416, ECO:0000269|PubMed:9659899}.
Q17R98 ZNF827 S477 ochoa Zinc finger protein 827 As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}.
Q2KHM9 KIAA0753 S772 ochoa Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}.
Q53GQ0 HSD17B12 S58 ochoa Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1) Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}.
Q5VT06 CEP350 S1061 ochoa Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}.
Q7Z3J3 RGPD4 S978 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z699 SPRED1 S105 ochoa|psp Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}.
Q86TC9 MYPN S960 ochoa Myopalladin (145 kDa sarcomeric protein) Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}.
Q86VI3 IQGAP3 S539 ochoa Ras GTPase-activating-like protein IQGAP3 None
Q86WH2 RASSF3 S137 ochoa Ras association domain-containing protein 3 None
Q86XI6 PPP1R3B S261 ochoa Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}.
Q8IWE5 PLEKHM2 S559 ochoa Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}.
Q8IWT3 CUL9 S976 ochoa Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (PubMed:38605244). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (PubMed:12526791, PubMed:17332328). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (PubMed:38605244). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (PubMed:38605244). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:38605244}.
Q8NF50 DOCK8 S1279 ochoa Dedicator of cytokinesis protein 8 Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}.
Q8TDB6 DTX3L S202 ochoa E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}.
Q8TER5 ARHGEF40 S255 ochoa Rho guanine nucleotide exchange factor 40 (Protein SOLO) May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Q8WVM8 SCFD1 S303 ochoa|psp Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}.
Q96A47 ISL2 S279 ochoa Insulin gene enhancer protein ISL-2 (Islet-2) Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. {ECO:0000250}.
Q96BI3 APH1A S110 psp Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor) Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12679784, PubMed:12763021, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12471034, PubMed:12522139, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). {ECO:0000269|PubMed:12297508, ECO:0000269|PubMed:12471034, ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12763021, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000305}.
Q96GG9 DCUN1D1 S59 ochoa DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:19617556, PubMed:23201271, PubMed:23401859, PubMed:26906416). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Also acts as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250|UniProtKB:Q9QZ73, ECO:0000269|PubMed:18826954, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:23401859, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:28581483}.
Q96MU7 YTHDC1 S424 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q96P47 AGAP3 S121 ochoa Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1) GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}.
Q96T17 MAP7D2 S273 ochoa MAP7 domain-containing protein 2 Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}.
Q99426 TBCB S65 psp Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}.
Q99666 RGPD5 S977 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9BZE9 ASPSCR1 S165 ochoa Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9) Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269|PubMed:23349634}.
Q9BZV1 UBXN6 S96 ochoa UBX domain-containing protein 6 (UBX domain-containing protein 1) May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269|PubMed:19275885, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856, ECO:0000269|PubMed:27753622}.
Q9C040 TRIM2 S428 ochoa Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}.
Q9H165 BCL11A S86 ochoa BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.
Q9H7U1 CCSER2 S630 ochoa Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}.
Q9NQA5 TRPV5 S299 psp Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:11549322, ECO:0000269|PubMed:18768590}.
Q9NW08 POLR3B S680 ochoa DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558766). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Forms Pol III active center together with the largest subunit POLR3A/RPC1. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (PubMed:19609254, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33674783, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000269|PubMed:34675218}.
Q9NX74 DUS2 S445 ochoa tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057, PubMed:38680565). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:38680565). Activity depends on the presence of guanosine at position 19 in the tRNA substrate (PubMed:38680565). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616). {ECO:0000269|PubMed:15994936, ECO:0000269|PubMed:18096616, ECO:0000269|PubMed:26429968, ECO:0000269|PubMed:30149704, ECO:0000269|PubMed:34798057, ECO:0000269|PubMed:38680565}.
Q9UBY9 HSPB7 S54 ochoa Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) None
Q9UHI6 DDX20 S187 ochoa Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.
Q9UKE5 TNIK S938 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9UKJ3 GPATCH8 S352 ochoa G patch domain-containing protein 8 None
Q9ULI3 HEG1 S1332 ochoa Protein HEG homolog 1 Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}.
Q9UPQ3 AGAP1 S101 ochoa Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1) GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}.
Q9Y2H9 MAST1 S139 ochoa Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}.
Q9Y2L6 FRMD4B S915 ochoa FERM domain-containing protein 4B (GRP1-binding protein GRSP1) Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.
Q9Y320 TMX2 S211 ochoa Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. {ECO:0000269|PubMed:31735293}.
Q9Y4G2 PLEKHM1 S432 ochoa Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}.
Q9Y5I7 CLDN16 S147 psp Claudin-16 (Paracellin-1) (PCLN-1) Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:16234325, PubMed:18188451, PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:10390358, PubMed:11518780, PubMed:14628289, PubMed:16528408, PubMed:28028216). {ECO:0000269|PubMed:10390358, ECO:0000269|PubMed:11518780, ECO:0000269|PubMed:14628289, ECO:0000269|PubMed:16234325, ECO:0000269|PubMed:16528408, ECO:0000269|PubMed:18188451, ECO:0000269|PubMed:28028216}.
P13667 PDIA4 Y137 Sugiyama Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) None
Q5R3I4 TTC38 S362 Sugiyama Tetratricopeptide repeat protein 38 (TPR repeat protein 38) None
P13667 PDIA4 Y252 Sugiyama Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) None
Q8NBS9 TXNDC5 Y262 Sugiyama Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. {ECO:0000250|UniProtKB:Q91W90}.
Q6UVK1 CSPG4 S1609 Sugiyama Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269|PubMed:10587647, ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:15210734}.
P10636 MAPT S641 SIGNOR|EPSD Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
Q8IU85 CAMK1D S159 Sugiyama Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.
P10636 MAPT S610 GPS6|EPSD Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
O95255 ABCC6 S66 Sugiyama ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6) [Isoform 1]: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644). {ECO:0000269|PubMed:11880368, ECO:0000269|PubMed:12414644, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 1]: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. {ECO:0000269|PubMed:24277820, ECO:0000269|PubMed:24969777}.; FUNCTION: [Isoform 2]: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. {ECO:0000269|PubMed:23912081}.
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reactome_id name p -log10_p
R-HSA-3371568 Attenuation phase 1.110223e-16 15.955
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 3.330669e-16 15.477
R-HSA-3371571 HSF1-dependent transactivation 8.881784e-16 15.051
R-HSA-3371556 Cellular response to heat stress 5.440093e-15 14.264
R-HSA-3371511 HSF1 activation 1.268097e-12 11.897
R-HSA-2262752 Cellular responses to stress 1.528806e-06 5.816
R-HSA-8953897 Cellular responses to stimuli 1.026255e-05 4.989
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 2.825560e-04 3.549
R-HSA-9833482 PKR-mediated signaling 4.916713e-04 3.308
R-HSA-913531 Interferon Signaling 7.682993e-04 3.114
R-HSA-180024 DARPP-32 events 2.220267e-03 2.654
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 2.892115e-03 2.539
R-HSA-2025928 Calcineurin activates NFAT 3.559858e-03 2.449
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 4.758089e-03 2.323
R-HSA-163765 ChREBP activates metabolic gene expression 4.799772e-03 2.319
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 5.483981e-03 2.261
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 6.977704e-03 2.156
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 6.977704e-03 2.156
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 7.382192e-03 2.132
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 7.785959e-03 2.109
R-HSA-8876725 Protein methylation 8.634314e-03 2.064
R-HSA-5690338 Defective ABCC6 causes PXE 2.864815e-02 1.543
R-HSA-5083630 Defective LFNG causes SCDO3 4.266556e-02 1.370
R-HSA-3595172 Defective CHST3 causes SEDCJD 6.331649e-02 1.198
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 6.331649e-02 1.198
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type 6.331649e-02 1.198
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 7.010150e-02 1.154
R-HSA-3595177 Defective CHSY1 causes TPBS 7.010150e-02 1.154
R-HSA-446107 Type I hemidesmosome assembly 7.683778e-02 1.114
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 8.352567e-02 1.078
R-HSA-9613354 Lipophagy 8.352567e-02 1.078
R-HSA-9700645 ALK mutants bind TKIs 8.352567e-02 1.078
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 9.016553e-02 1.045
R-HSA-2022923 DS-GAG biosynthesis 1.033025e-01 0.986
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1.098003e-01 0.959
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.862297e-02 1.543
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 3.009455e-02 1.522
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 3.009455e-02 1.522
R-HSA-73780 RNA Polymerase III Chain Elongation 1.290148e-01 0.889
R-HSA-1855170 IPs transport between nucleus and cytosol 3.312580e-02 1.480
R-HSA-159227 Transport of the SLBP independent Mature mRNA 3.312580e-02 1.480
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.468450e-02 1.460
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.788559e-02 1.422
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 1.415955e-01 0.849
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 1.415955e-01 0.849
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 1.478181e-01 0.830
R-HSA-194441 Metabolism of non-coding RNA 1.317744e-02 1.880
R-HSA-191859 snRNP Assembly 1.317744e-02 1.880
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 4.460931e-02 1.351
R-HSA-73980 RNA Polymerase III Transcription Termination 1.539960e-01 0.812
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 4.635452e-02 1.334
R-HSA-1912420 Pre-NOTCH Processing in Golgi 1.601295e-01 0.796
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.662188e-01 0.779
R-HSA-2022870 CS-GAG biosynthesis 1.782666e-01 0.749
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 1.782666e-01 0.749
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 1.782666e-01 0.749
R-HSA-72649 Translation initiation complex formation 7.527022e-02 1.123
R-HSA-141424 Amplification of signal from the kinetochores 3.164890e-02 1.500
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.164890e-02 1.500
R-HSA-72702 Ribosomal scanning and start codon recognition 7.947176e-02 1.100
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.647912e-01 0.783
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.673517e-01 0.776
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 1.776607e-01 0.750
R-HSA-72689 Formation of a pool of free 40S subunits 1.802537e-01 0.744
R-HSA-192823 Viral mRNA Translation 2.011891e-01 0.696
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.144159e-01 0.669
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.170716e-01 0.663
R-HSA-1980145 Signaling by NOTCH2 3.627125e-02 1.440
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 1.564497e-02 1.806
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 1.396229e-01 0.855
R-HSA-156902 Peptide chain elongation 1.571541e-01 0.804
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 2.190904e-01 0.659
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.177965e-01 0.929
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.591789e-01 0.798
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.190904e-01 0.659
R-HSA-9930044 Nuclear RNA decay 3.312580e-02 1.480
R-HSA-72764 Eukaryotic Translation Termination 1.802537e-01 0.744
R-HSA-69618 Mitotic Spindle Checkpoint 4.776070e-02 1.321
R-HSA-9017802 Noncanonical activation of NOTCH3 5.648240e-02 1.248
R-HSA-176974 Unwinding of DNA 8.352567e-02 1.078
R-HSA-451306 Ionotropic activity of kainate receptors 9.675769e-02 1.014
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 9.675769e-02 1.014
R-HSA-432720 Lysosome Vesicle Biogenesis 3.952703e-02 1.403
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 3.952703e-02 1.403
R-HSA-180910 Vpr-mediated nuclear import of PICs 4.119510e-02 1.385
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 1.539960e-01 0.812
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 5.733144e-02 1.242
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1.782666e-01 0.749
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1.842256e-01 0.735
R-HSA-350054 Notch-HLH transcription pathway 1.842256e-01 0.735
R-HSA-9613829 Chaperone Mediated Autophagy 1.539960e-01 0.812
R-HSA-6794361 Neurexins and neuroligins 7.114331e-02 1.148
R-HSA-156842 Eukaryotic Translation Elongation 1.699191e-01 0.770
R-HSA-9620244 Long-term potentiation 2.018467e-01 0.695
R-HSA-8963888 Chylomicron assembly 9.675769e-02 1.014
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.468450e-02 1.460
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 1.842256e-01 0.735
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 1.842256e-01 0.735
R-HSA-8868773 rRNA processing in the nucleus and cytosol 1.913457e-01 0.718
R-HSA-6798695 Neutrophil degranulation 1.358107e-01 0.867
R-HSA-6794362 Protein-protein interactions at synapses 3.080769e-02 1.511
R-HSA-8849932 Synaptic adhesion-like molecules 1.539960e-01 0.812
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.835577e-02 1.736
R-HSA-8964041 LDL remodeling 7.010150e-02 1.154
R-HSA-9839383 TGFBR3 PTM regulation 7.683778e-02 1.114
R-HSA-168330 Viral RNP Complexes in the Host Cell Nucleus 1.033025e-01 0.986
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 3.627125e-02 1.440
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 1.071700e-02 1.970
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 1.601295e-01 0.796
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 1.722645e-01 0.764
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 5.924117e-02 1.227
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 1.960153e-01 0.708
R-HSA-420029 Tight junction interactions 2.018467e-01 0.695
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 8.374497e-02 1.077
R-HSA-451326 Activation of kainate receptors upon glutamate binding 2.190904e-01 0.659
R-HSA-168325 Viral Messenger RNA Synthesis 9.028283e-02 1.044
R-HSA-6809371 Formation of the cornified envelope 7.999883e-02 1.097
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.170716e-01 0.663
R-HSA-112310 Neurotransmitter release cycle 1.622380e-01 0.790
R-HSA-68877 Mitotic Prometaphase 2.005621e-01 0.698
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.154289e-01 0.938
R-HSA-204005 COPII-mediated vesicle transport 1.107315e-01 0.956
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 7.604057e-02 1.119
R-HSA-9663891 Selective autophagy 1.571541e-01 0.804
R-HSA-180746 Nuclear import of Rev protein 3.627125e-02 1.440
R-HSA-432722 Golgi Associated Vesicle Biogenesis 7.319725e-02 1.136
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.803596e-02 1.420
R-HSA-2408557 Selenocysteine synthesis 1.959262e-01 0.708
R-HSA-1912422 Pre-NOTCH Expression and Processing 6.350709e-02 1.197
R-HSA-8953854 Metabolism of RNA 4.751333e-02 1.323
R-HSA-447038 NrCAM interactions 4.959887e-02 1.305
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 7.010150e-02 1.154
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.290148e-01 0.889
R-HSA-177243 Interactions of Rev with host cellular proteins 4.635452e-02 1.334
R-HSA-176033 Interactions of Vpr with host cellular proteins 4.635452e-02 1.334
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4.812455e-02 1.318
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 1.782666e-01 0.749
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 2.076361e-01 0.683
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 2.038269e-01 0.691
R-HSA-2467813 Separation of Sister Chromatids 1.471647e-01 0.832
R-HSA-157118 Signaling by NOTCH 1.218926e-01 0.914
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 1.985555e-01 0.702
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.662188e-01 0.779
R-HSA-199991 Membrane Trafficking 2.142697e-01 0.669
R-HSA-8874177 ATF6B (ATF6-beta) activates chaperones 2.864815e-02 1.543
R-HSA-8866423 VLDL assembly 6.331649e-02 1.198
R-HSA-447041 CHL1 interactions 7.010150e-02 1.154
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 8.352567e-02 1.078
R-HSA-193692 Regulated proteolysis of p75NTR 8.352567e-02 1.078
R-HSA-5682910 LGI-ADAM interactions 9.675769e-02 1.014
R-HSA-111447 Activation of BAD and translocation to mitochondria 1.290148e-01 0.889
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.290148e-01 0.889
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 1.353278e-01 0.869
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 4.288935e-02 1.368
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.076361e-01 0.683
R-HSA-5578749 Transcriptional regulation by small RNAs 1.154289e-01 0.938
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 5.878836e-02 1.231
R-HSA-381042 PERK regulates gene expression 3.788559e-02 1.422
R-HSA-438064 Post NMDA receptor activation events 1.546238e-01 0.811
R-HSA-73621 Pyrimidine catabolism 5.357906e-02 1.271
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.162514e-01 0.935
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.290148e-01 0.889
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 1.353278e-01 0.869
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 1.478181e-01 0.830
R-HSA-168276 NS1 Mediated Effects on Host Pathways 4.460931e-02 1.351
R-HSA-75105 Fatty acyl-CoA biosynthesis 1.107315e-01 0.956
R-HSA-8963898 Plasma lipoprotein assembly 1.960153e-01 0.708
R-HSA-68886 M Phase 1.705534e-01 0.768
R-HSA-2980766 Nuclear Envelope Breakdown 8.159959e-02 1.088
R-HSA-9932451 SWI/SNF chromatin remodelers 2.018467e-01 0.695
R-HSA-9932444 ATP-dependent chromatin remodelers 2.018467e-01 0.695
R-HSA-9010642 ROBO receptors bind AKAP5 7.683778e-02 1.114
R-HSA-9828642 Respiratory syncytial virus genome transcription 1.226561e-01 0.911
R-HSA-205043 NRIF signals cell death from the nucleus 1.226561e-01 0.911
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 2.076361e-01 0.683
R-HSA-3295583 TRP channels 2.076361e-01 0.683
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 2.190904e-01 0.659
R-HSA-6784531 tRNA processing in the nucleus 9.249486e-02 1.034
R-HSA-168255 Influenza Infection 1.516643e-02 1.819
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 1.842256e-01 0.735
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 1.107315e-01 0.956
R-HSA-68882 Mitotic Anaphase 9.396095e-02 1.027
R-HSA-2555396 Mitotic Metaphase and Anaphase 9.505708e-02 1.022
R-HSA-264876 Insulin processing 2.133839e-01 0.671
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.177965e-01 0.929
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 1.722645e-01 0.764
R-HSA-4086398 Ca2+ pathway 1.177965e-01 0.929
R-HSA-9827857 Specification of primordial germ cells 1.141389e-02 1.943
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 8.352567e-02 1.078
R-HSA-8949215 Mitochondrial calcium ion transport 1.679262e-02 1.775
R-HSA-193048 Androgen biosynthesis 1.782666e-01 0.749
R-HSA-73614 Pyrimidine salvage 2.190904e-01 0.659
R-HSA-9013694 Signaling by NOTCH4 1.201765e-01 0.920
R-HSA-69620 Cell Cycle Checkpoints 1.449135e-01 0.839
R-HSA-68875 Mitotic Prophase 7.474109e-02 1.126
R-HSA-70171 Glycolysis 1.933015e-01 0.714
R-HSA-9020933 Interleukin-23 signaling 7.683778e-02 1.114
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 5.763573e-02 1.239
R-HSA-1912408 Pre-NOTCH Transcription and Translation 3.694715e-02 1.432
R-HSA-3000170 Syndecan interactions 1.901417e-01 0.721
R-HSA-3000157 Laminin interactions 2.018467e-01 0.695
R-HSA-5607764 CLEC7A (Dectin-1) signaling 1.828525e-01 0.738
R-HSA-376176 Signaling by ROBO receptors 7.926769e-02 1.101
R-HSA-1169408 ISG15 antiviral mechanism 1.225684e-01 0.912
R-HSA-2672351 Stimuli-sensing channels 2.170716e-01 0.663
R-HSA-3000171 Non-integrin membrane-ECM interactions 1.225684e-01 0.912
R-HSA-381119 Unfolded Protein Response (UPR) 1.055354e-01 0.977
R-HSA-193704 p75 NTR receptor-mediated signalling 1.906816e-01 0.720
R-HSA-9705683 SARS-CoV-2-host interactions 3.531101e-02 1.452
R-HSA-1474290 Collagen formation 1.750738e-01 0.757
R-HSA-2559580 Oxidative Stress Induced Senescence 1.985555e-01 0.702
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 2.439050e-02 1.613
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 9.472267e-02 1.024
R-HSA-9700206 Signaling by ALK in cancer 2.144159e-01 0.669
R-HSA-1236394 Signaling by ERBB4 1.201765e-01 0.920
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.322500e-01 0.879
R-HSA-72306 tRNA processing 1.591789e-01 0.798
R-HSA-111885 Opioid Signalling 5.203776e-02 1.284
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 1.273870e-01 0.895
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.144159e-01 0.669
R-HSA-211000 Gene Silencing by RNA 2.144159e-01 0.669
R-HSA-422475 Axon guidance 1.189718e-01 0.925
R-HSA-9675108 Nervous system development 1.502055e-01 0.823
R-HSA-9692914 SARS-CoV-1-host interactions 2.117634e-01 0.674
R-HSA-9694516 SARS-CoV-2 Infection 1.320148e-01 0.879
R-HSA-1280215 Cytokine Signaling in Immune system 1.011314e-01 0.995
R-HSA-9615710 Late endosomal microautophagy 2.247558e-01 0.648
R-HSA-6805567 Keratinization 2.268965e-01 0.644
R-HSA-927802 Nonsense-Mediated Decay (NMD) 2.277229e-01 0.643
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2.277229e-01 0.643
R-HSA-1483249 Inositol phosphate metabolism 2.277229e-01 0.643
R-HSA-68962 Activation of the pre-replicative complex 2.303805e-01 0.638
R-HSA-76046 RNA Polymerase III Transcription Initiation 2.303805e-01 0.638
R-HSA-888590 GABA synthesis, release, reuptake and degradation 2.303805e-01 0.638
R-HSA-114452 Activation of BH3-only proteins 2.303805e-01 0.638
R-HSA-399719 Trafficking of AMPA receptors 2.359646e-01 0.627
R-HSA-112315 Transmission across Chemical Synapses 2.395631e-01 0.621
R-HSA-2871809 FCERI mediated Ca+2 mobilization 2.410880e-01 0.618
R-HSA-69190 DNA strand elongation 2.415087e-01 0.617
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.415087e-01 0.617
R-HSA-72737 Cap-dependent Translation Initiation 2.437661e-01 0.613
R-HSA-72613 Eukaryotic Translation Initiation 2.437661e-01 0.613
R-HSA-373760 L1CAM interactions 2.437661e-01 0.613
R-HSA-70326 Glucose metabolism 2.464455e-01 0.608
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 2.470128e-01 0.607
R-HSA-176187 Activation of ATR in response to replication stress 2.470128e-01 0.607
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 2.470128e-01 0.607
R-HSA-2024101 CS/DS degradation 2.524773e-01 0.598
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 2.524773e-01 0.598
R-HSA-69278 Cell Cycle, Mitotic 2.552364e-01 0.593
R-HSA-1971475 Glycosaminoglycan-protein linkage region biosynthesis 2.579025e-01 0.589
R-HSA-5205647 Mitophagy 2.579025e-01 0.589
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 2.579025e-01 0.589
R-HSA-162909 Host Interactions of HIV factors 2.652254e-01 0.576
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 2.686361e-01 0.571
R-HSA-74158 RNA Polymerase III Transcription 2.686361e-01 0.571
R-HSA-72312 rRNA processing 2.773182e-01 0.557
R-HSA-8956319 Nucleotide catabolism 2.813292e-01 0.551
R-HSA-112316 Neuronal System 2.832494e-01 0.548
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 2.844485e-01 0.546
R-HSA-1474165 Reproduction 2.866929e-01 0.543
R-HSA-1251985 Nuclear signaling by ERBB4 2.896436e-01 0.538
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 2.948013e-01 0.530
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 2.999219e-01 0.523
R-HSA-3858494 Beta-catenin independent WNT signaling 3.054293e-01 0.515
R-HSA-163685 Integration of energy metabolism 3.054293e-01 0.515
R-HSA-5619115 Disorders of transmembrane transporters 3.069317e-01 0.513
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 3.100527e-01 0.509
R-HSA-9948299 Ribosome-associated quality control 3.107681e-01 0.508
R-HSA-3214858 RMTs methylate histone arginines 3.150635e-01 0.502
R-HSA-1632852 Macroautophagy 3.187608e-01 0.497
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 3.200382e-01 0.495
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.240778e-01 0.489
R-HSA-162599 Late Phase of HIV Life Cycle 3.240778e-01 0.489
R-HSA-9839373 Signaling by TGFBR3 3.249770e-01 0.488
R-HSA-75153 Apoptotic execution phase 3.249770e-01 0.488
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.298803e-01 0.482
R-HSA-8963899 Plasma lipoprotein remodeling 3.347483e-01 0.475
R-HSA-199977 ER to Golgi Anterograde Transport 3.373236e-01 0.472
R-HSA-9734767 Developmental Cell Lineages 3.386600e-01 0.470
R-HSA-5658442 Regulation of RAS by GAPs 3.443793e-01 0.463
R-HSA-5358346 Hedgehog ligand biogenesis 3.491429e-01 0.457
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 3.504932e-01 0.455
R-HSA-68949 Orc1 removal from chromatin 3.538721e-01 0.451
R-HSA-73887 Death Receptor Signaling 3.557371e-01 0.449
R-HSA-9612973 Autophagy 3.609664e-01 0.443
R-HSA-9610379 HCMV Late Events 3.635753e-01 0.439
R-HSA-162587 HIV Life Cycle 3.635753e-01 0.439
R-HSA-9711097 Cellular response to starvation 3.661802e-01 0.436
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 3.661802e-01 0.436
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 3.678563e-01 0.434
R-HSA-9012852 Signaling by NOTCH3 3.678563e-01 0.434
R-HSA-877300 Interferon gamma signaling 3.687812e-01 0.433
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 3.703197e-01 0.431
R-HSA-193648 NRAGE signals death through JNK 3.724507e-01 0.429
R-HSA-5578775 Ion homeostasis 3.724507e-01 0.429
R-HSA-3299685 Detoxification of Reactive Oxygen Species 3.724507e-01 0.429
R-HSA-5654736 Signaling by FGFR1 3.724507e-01 0.429
R-HSA-109606 Intrinsic Pathway for Apoptosis 3.724507e-01 0.429
R-HSA-109581 Apoptosis 3.765592e-01 0.424
R-HSA-2408522 Selenoamino acid metabolism 3.817232e-01 0.418
R-HSA-429914 Deadenylation-dependent mRNA decay 3.860362e-01 0.413
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 3.860362e-01 0.413
R-HSA-5619102 SLC transporter disorders 3.894355e-01 0.410
R-HSA-983189 Kinesins 3.904995e-01 0.408
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3.904995e-01 0.408
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3.904995e-01 0.408
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3.904995e-01 0.408
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3.904995e-01 0.408
R-HSA-2644603 Signaling by NOTCH1 in Cancer 3.904995e-01 0.408
R-HSA-8956321 Nucleotide salvage 3.949307e-01 0.403
R-HSA-5653656 Vesicle-mediated transport 3.975006e-01 0.401
R-HSA-1268020 Mitochondrial protein import 3.993300e-01 0.399
R-HSA-5621481 C-type lectin receptors (CLRs) 4.021953e-01 0.396
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 4.036975e-01 0.394
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.036975e-01 0.394
R-HSA-6790901 rRNA modification in the nucleus and cytosol 4.036975e-01 0.394
R-HSA-5689880 Ub-specific processing proteases 4.072647e-01 0.390
R-HSA-9679506 SARS-CoV Infections 4.079081e-01 0.389
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 4.123137e-01 0.385
R-HSA-9678108 SARS-CoV-1 Infection 4.123137e-01 0.385
R-HSA-8854518 AURKA Activation by TPX2 4.166121e-01 0.380
R-HSA-6782315 tRNA modification in the nucleus and cytosol 4.166121e-01 0.380
R-HSA-196071 Metabolism of steroid hormones 4.208550e-01 0.376
R-HSA-2559583 Cellular Senescence 4.248438e-01 0.372
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 4.250674e-01 0.372
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 4.334011e-01 0.363
R-HSA-3781865 Diseases of glycosylation 4.347692e-01 0.362
R-HSA-1640170 Cell Cycle 4.371350e-01 0.359
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 4.375230e-01 0.359
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 4.456777e-01 0.351
R-HSA-69052 Switching of origins to a post-replicative state 4.456777e-01 0.351
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 4.456777e-01 0.351
R-HSA-983712 Ion channel transport 4.470475e-01 0.350
R-HSA-380287 Centrosome maturation 4.537152e-01 0.343
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 4.543438e-01 0.343
R-HSA-8957322 Metabolism of steroids 4.574172e-01 0.340
R-HSA-1980143 Signaling by NOTCH1 4.576905e-01 0.339
R-HSA-9020591 Interleukin-12 signaling 4.576905e-01 0.339
R-HSA-9609690 HCMV Early Events 4.639872e-01 0.333
R-HSA-383280 Nuclear Receptor transcription pathway 4.655553e-01 0.332
R-HSA-416482 G alpha (12/13) signalling events 4.655553e-01 0.332
R-HSA-5619084 ABC transporter disorders 4.655553e-01 0.332
R-HSA-168256 Immune System 4.692651e-01 0.329
R-HSA-1474244 Extracellular matrix organization 4.705537e-01 0.327
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.733070e-01 0.325
R-HSA-977225 Amyloid fiber formation 4.771409e-01 0.321
R-HSA-948021 Transport to the Golgi and subsequent modification 4.782656e-01 0.320
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 4.806230e-01 0.318
R-HSA-5357801 Programmed Cell Death 4.876567e-01 0.312
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.884775e-01 0.311
R-HSA-6802957 Oncogenic MAPK signaling 4.922019e-01 0.308
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 4.958995e-01 0.305
R-HSA-70268 Pyruvate metabolism 5.032146e-01 0.298
R-HSA-447115 Interleukin-12 family signaling 5.032146e-01 0.298
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 5.038386e-01 0.298
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.068327e-01 0.295
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 5.139905e-01 0.289
R-HSA-381070 IRE1alpha activates chaperones 5.210454e-01 0.283
R-HSA-168249 Innate Immune System 5.224475e-01 0.282
R-HSA-8951664 Neddylation 5.241593e-01 0.281
R-HSA-391251 Protein folding 5.245346e-01 0.280
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 5.245346e-01 0.280
R-HSA-2682334 EPH-Ephrin signaling 5.245346e-01 0.280
R-HSA-68867 Assembly of the pre-replicative complex 5.279987e-01 0.277
R-HSA-162906 HIV Infection 5.373967e-01 0.270
R-HSA-6807878 COPI-mediated anterograde transport 5.416065e-01 0.266
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 5.416065e-01 0.266
R-HSA-8957275 Post-translational protein phosphorylation 5.482637e-01 0.261
R-HSA-190236 Signaling by FGFR 5.482637e-01 0.261
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.486751e-01 0.261
R-HSA-382556 ABC-family proteins mediated transport 5.548252e-01 0.256
R-HSA-15869 Metabolism of nucleotides 5.567794e-01 0.254
R-HSA-1266738 Developmental Biology 5.757435e-01 0.240
R-HSA-69239 Synthesis of DNA 5.801392e-01 0.236
R-HSA-4839726 Chromatin organization 5.837589e-01 0.234
R-HSA-9609646 HCMV Infection 5.857841e-01 0.232
R-HSA-69002 DNA Replication Pre-Initiation 5.862414e-01 0.232
R-HSA-6803157 Antimicrobial peptides 5.922557e-01 0.227
R-HSA-5688426 Deubiquitination 5.958017e-01 0.225
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 6.040254e-01 0.219
R-HSA-418594 G alpha (i) signalling events 6.041661e-01 0.219
R-HSA-9007101 Rab regulation of trafficking 6.154582e-01 0.211
R-HSA-2980736 Peptide hormone metabolism 6.154582e-01 0.211
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.319966e-01 0.199
R-HSA-2132295 MHC class II antigen presentation 6.319966e-01 0.199
R-HSA-446728 Cell junction organization 6.395652e-01 0.194
R-HSA-69206 G1/S Transition 6.399993e-01 0.194
R-HSA-114608 Platelet degranulation 6.452384e-01 0.190
R-HSA-69481 G2/M Checkpoints 6.452384e-01 0.190
R-HSA-5576891 Cardiac conduction 6.580076e-01 0.182
R-HSA-5673001 RAF/MAP kinase cascade 6.591579e-01 0.181
R-HSA-8856688 Golgi-to-ER retrograde transport 6.605062e-01 0.180
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 6.629867e-01 0.178
R-HSA-5684996 MAPK1/MAPK3 signaling 6.711814e-01 0.173
R-HSA-195721 Signaling by WNT 6.745537e-01 0.171
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 6.751224e-01 0.171
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 6.755246e-01 0.170
R-HSA-5358351 Signaling by Hedgehog 6.774970e-01 0.169
R-HSA-597592 Post-translational protein modification 6.864252e-01 0.163
R-HSA-8856828 Clathrin-mediated endocytosis 6.913876e-01 0.160
R-HSA-453279 Mitotic G1 phase and G1/S transition 6.981088e-01 0.156
R-HSA-69242 S Phase 7.025087e-01 0.153
R-HSA-1500931 Cell-Cell communication 7.036649e-01 0.153
R-HSA-69306 DNA Replication 7.132324e-01 0.147
R-HSA-9609507 Protein localization 7.132324e-01 0.147
R-HSA-9006936 Signaling by TGFB family members 7.276046e-01 0.138
R-HSA-9824446 Viral Infection Pathways 7.361501e-01 0.133
R-HSA-382551 Transport of small molecules 7.422432e-01 0.129
R-HSA-5683057 MAPK family signaling cascades 7.487520e-01 0.126
R-HSA-9006931 Signaling by Nuclear Receptors 7.696555e-01 0.114
R-HSA-69275 G2/M Transition 7.766547e-01 0.110
R-HSA-453274 Mitotic G2-G2/M phases 7.799182e-01 0.108
R-HSA-5617833 Cilium Assembly 7.831344e-01 0.106
R-HSA-1630316 Glycosaminoglycan metabolism 7.878716e-01 0.104
R-HSA-72163 mRNA Splicing - Major Pathway 7.894277e-01 0.103
R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.948039e-01 0.100
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 7.985297e-01 0.098
R-HSA-162582 Signal Transduction 8.039818e-01 0.095
R-HSA-72172 mRNA Splicing 8.058159e-01 0.094
R-HSA-397014 Muscle contraction 8.169341e-01 0.088
R-HSA-8978868 Fatty acid metabolism 8.205748e-01 0.086
R-HSA-388396 GPCR downstream signalling 8.346288e-01 0.079
R-HSA-446203 Asparagine N-linked glycosylation 8.351857e-01 0.078
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.396954e-01 0.076
R-HSA-5668914 Diseases of metabolism 8.398143e-01 0.076
R-HSA-72766 Translation 8.416329e-01 0.075
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 8.435514e-01 0.074
R-HSA-3247509 Chromatin modifying enzymes 8.443592e-01 0.073
R-HSA-449147 Signaling by Interleukins 8.525729e-01 0.069
R-HSA-392499 Metabolism of proteins 8.598977e-01 0.066
R-HSA-421270 Cell-cell junction organization 8.627249e-01 0.064
R-HSA-9711123 Cellular response to chemical stress 8.789399e-01 0.056
R-HSA-76002 Platelet activation, signaling and aggregation 8.841970e-01 0.053
R-HSA-372790 Signaling by GPCR 8.864196e-01 0.052
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.908559e-01 0.050
R-HSA-1280218 Adaptive Immune System 8.934594e-01 0.049
R-HSA-1852241 Organelle biogenesis and maintenance 9.176519e-01 0.037
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.295446e-01 0.032
R-HSA-109582 Hemostasis 9.356944e-01 0.029
R-HSA-196854 Metabolism of vitamins and cofactors 9.406227e-01 0.027
R-HSA-71291 Metabolism of amino acids and derivatives 9.488818e-01 0.023
R-HSA-5663205 Infectious disease 9.710615e-01 0.013
R-HSA-1643685 Disease 9.818068e-01 0.008
R-HSA-556833 Metabolism of lipids 9.991429e-01 0.000
R-HSA-74160 Gene expression (Transcription) 9.992439e-01 0.000
R-HSA-212436 Generic Transcription Pathway 9.999182e-01 0.000
R-HSA-73857 RNA Polymerase II Transcription 9.999717e-01 0.000
R-HSA-1430728 Metabolism 9.999740e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.806 0.357 1 0.778
CDK8CDK8 0.804 0.535 1 0.890
CDK18CDK18 0.804 0.558 1 0.900
CDK19CDK19 0.802 0.526 1 0.896
CDK17CDK17 0.801 0.565 1 0.904
KISKIS 0.799 0.473 1 0.887
CDK13CDK13 0.799 0.546 1 0.901
JNK2JNK2 0.799 0.578 1 0.915
P38GP38G 0.798 0.566 1 0.909
CDK5CDK5 0.796 0.533 1 0.887
CDK12CDK12 0.796 0.546 1 0.905
CDK1CDK1 0.796 0.527 1 0.914
DYRK2DYRK2 0.796 0.483 1 0.858
HIPK2HIPK2 0.794 0.478 1 0.873
CDK7CDK7 0.794 0.502 1 0.899
CLK2CLK2 0.794 0.324 -3 0.567
CDK9CDK9 0.794 0.533 1 0.902
CDK16CDK16 0.791 0.540 1 0.899
CDK3CDK3 0.791 0.478 1 0.906
JNK3JNK3 0.791 0.557 1 0.905
CLK1CLK1 0.791 0.299 -3 0.579
DYRK4DYRK4 0.791 0.502 1 0.894
MTORMTOR 0.790 0.318 1 0.619
NLKNLK 0.789 0.468 1 0.790
SRPK1SRPK1 0.789 0.222 -3 0.554
ERK1ERK1 0.789 0.518 1 0.894
CDK14CDK14 0.787 0.539 1 0.895
CDK10CDK10 0.787 0.504 1 0.897
CLK4CLK4 0.786 0.272 -3 0.580
P38BP38B 0.786 0.525 1 0.893
DYRK1BDYRK1B 0.785 0.472 1 0.880
HIPK1HIPK1 0.785 0.441 1 0.853
HIPK4HIPK4 0.785 0.285 1 0.744
P38AP38A 0.783 0.510 1 0.869
P38DP38D 0.782 0.537 1 0.888
SRPK2SRPK2 0.781 0.170 -3 0.495
ERK2ERK2 0.779 0.502 1 0.888
CDK2CDK2 0.779 0.402 1 0.873
COTCOT 0.778 -0.020 2 0.890
ERK5ERK5 0.777 0.238 1 0.703
DYRK1ADYRK1A 0.775 0.363 1 0.860
HIPK3HIPK3 0.775 0.416 1 0.830
DYRK3DYRK3 0.775 0.357 1 0.821
CDK6CDK6 0.773 0.506 1 0.890
MST4MST4 0.772 0.095 2 0.858
JNK1JNK1 0.772 0.497 1 0.913
NUAK2NUAK2 0.771 0.059 -3 0.640
CDK4CDK4 0.771 0.511 1 0.904
MARK4MARK4 0.771 0.107 4 0.838
CDC7CDC7 0.770 -0.031 1 0.531
CDKL1CDKL1 0.770 0.092 -3 0.590
ICKICK 0.770 0.205 -3 0.615
NDR2NDR2 0.770 0.008 -3 0.629
WNK1WNK1 0.770 0.040 -2 0.879
SRPK3SRPK3 0.769 0.147 -3 0.521
CDKL5CDKL5 0.768 0.085 -3 0.588
SKMLCKSKMLCK 0.768 0.027 -2 0.868
PRPKPRPK 0.767 -0.047 -1 0.656
GCN2GCN2 0.766 -0.085 2 0.824
CAMK1BCAMK1B 0.765 -0.007 -3 0.659
DSTYKDSTYK 0.764 -0.066 2 0.916
RSK2RSK2 0.764 0.007 -3 0.584
PIM3PIM3 0.764 -0.050 -3 0.621
PRP4PRP4 0.764 0.281 -3 0.558
PKN3PKN3 0.764 -0.015 -3 0.627
NIM1NIM1 0.764 0.116 3 0.733
PKCDPKCD 0.764 0.044 2 0.806
PKN2PKN2 0.763 0.004 -3 0.659
NDR1NDR1 0.763 -0.016 -3 0.639
QSKQSK 0.762 0.088 4 0.819
RAF1RAF1 0.762 -0.117 1 0.512
ULK2ULK2 0.761 -0.109 2 0.796
MOSMOS 0.760 -0.068 1 0.554
PDHK4PDHK4 0.760 -0.125 1 0.557
NEK6NEK6 0.760 -0.036 -2 0.839
BMPR2BMPR2 0.760 -0.118 -2 0.854
TBK1TBK1 0.760 -0.136 1 0.440
HUNKHUNK 0.760 -0.059 2 0.839
TGFBR2TGFBR2 0.759 -0.039 -2 0.795
NIKNIK 0.759 -0.018 -3 0.676
P90RSKP90RSK 0.759 -0.014 -3 0.569
RSK3RSK3 0.759 -0.011 -3 0.577
PRKD1PRKD1 0.759 -0.034 -3 0.620
AMPKA1AMPKA1 0.759 -0.009 -3 0.662
QIKQIK 0.758 0.054 -3 0.648
SIKSIK 0.758 0.054 -3 0.591
TSSK1TSSK1 0.758 0.012 -3 0.674
PKACGPKACG 0.758 0.001 -2 0.759
PRKD2PRKD2 0.758 -0.023 -3 0.598
MAKMAK 0.757 0.305 -2 0.686
MARK3MARK3 0.757 0.078 4 0.780
IKKBIKKB 0.757 -0.153 -2 0.725
SGK3SGK3 0.757 0.049 -3 0.612
MNK2MNK2 0.756 0.021 -2 0.805
AURCAURC 0.756 0.033 -2 0.691
PIM1PIM1 0.756 -0.008 -3 0.587
CAMLCKCAMLCK 0.756 -0.002 -2 0.843
DAPK2DAPK2 0.755 -0.008 -3 0.657
PDHK1PDHK1 0.755 -0.125 1 0.530
PKCGPKCG 0.755 0.029 2 0.773
ATRATR 0.755 -0.061 1 0.518
CAMK2GCAMK2G 0.755 -0.083 2 0.823
AMPKA2AMPKA2 0.755 -0.011 -3 0.640
IKKEIKKE 0.755 -0.153 1 0.437
NEK7NEK7 0.755 -0.119 -3 0.591
PKCBPKCB 0.754 0.023 2 0.775
GRK5GRK5 0.754 -0.098 -3 0.657
CAMK2DCAMK2D 0.754 -0.051 -3 0.650
LATS2LATS2 0.754 -0.044 -5 0.769
PKCAPKCA 0.754 0.050 2 0.756
BMPR1BBMPR1B 0.754 0.033 1 0.527
MAPKAPK3MAPKAPK3 0.753 -0.069 -3 0.609
P70S6KBP70S6KB 0.753 -0.028 -3 0.616
WNK3WNK3 0.753 -0.142 1 0.483
MNK1MNK1 0.753 0.023 -2 0.808
MARK2MARK2 0.753 0.072 4 0.762
NUAK1NUAK1 0.752 -0.021 -3 0.616
PKACBPKACB 0.751 0.034 -2 0.701
TSSK2TSSK2 0.751 -0.038 -5 0.848
CHAK2CHAK2 0.751 -0.076 -1 0.666
RIPK3RIPK3 0.751 -0.136 3 0.743
IRE1IRE1 0.750 -0.057 1 0.456
TGFBR1TGFBR1 0.750 0.030 -2 0.808
RSK4RSK4 0.749 -0.001 -3 0.541
BCKDKBCKDK 0.749 -0.108 -1 0.602
IKKAIKKA 0.749 -0.095 -2 0.706
MLK1MLK1 0.749 -0.131 2 0.844
ULK1ULK1 0.749 -0.157 -3 0.592
PKCHPKCH 0.749 0.003 2 0.754
PAK6PAK6 0.748 0.033 -2 0.706
ALK4ALK4 0.748 0.002 -2 0.833
AKT2AKT2 0.748 0.018 -3 0.527
MAPKAPK2MAPKAPK2 0.748 -0.050 -3 0.563
MOKMOK 0.748 0.271 1 0.764
PRKXPRKX 0.748 0.041 -3 0.531
PKCZPKCZ 0.748 -0.005 2 0.806
BRSK1BRSK1 0.747 -0.024 -3 0.615
MARK1MARK1 0.747 0.040 4 0.795
ERK7ERK7 0.747 0.204 2 0.619
LATS1LATS1 0.747 -0.002 -3 0.636
MSK2MSK2 0.747 -0.042 -3 0.540
MASTLMASTL 0.746 -0.131 -2 0.797
BRSK2BRSK2 0.746 -0.030 -3 0.648
DNAPKDNAPK 0.746 0.017 1 0.439
NEK9NEK9 0.746 -0.147 2 0.851
PAK1PAK1 0.746 -0.033 -2 0.773
GRK1GRK1 0.746 -0.059 -2 0.769
PRKD3PRKD3 0.745 -0.044 -3 0.575
MELKMELK 0.745 -0.075 -3 0.639
PHKG1PHKG1 0.745 -0.065 -3 0.633
NEK2NEK2 0.745 -0.065 2 0.834
CAMK4CAMK4 0.745 -0.095 -3 0.637
DCAMKL1DCAMKL1 0.744 0.005 -3 0.613
ANKRD3ANKRD3 0.744 -0.131 1 0.513
ATMATM 0.744 -0.065 1 0.462
CAMK2BCAMK2B 0.743 -0.045 2 0.798
PAK3PAK3 0.743 -0.062 -2 0.770
MSK1MSK1 0.743 -0.018 -3 0.566
IRE2IRE2 0.743 -0.066 2 0.750
GRK7GRK7 0.743 0.006 1 0.528
PKG2PKG2 0.743 -0.005 -2 0.701
AURBAURB 0.743 0.005 -2 0.685
RIPK1RIPK1 0.742 -0.167 1 0.474
MLK2MLK2 0.742 -0.133 2 0.833
CAMK2ACAMK2A 0.742 -0.048 2 0.822
MLK3MLK3 0.742 -0.068 2 0.779
PKRPKR 0.742 -0.046 1 0.505
MEK1MEK1 0.742 -0.035 2 0.861
GRK6GRK6 0.741 -0.140 1 0.538
MYLK4MYLK4 0.741 -0.029 -2 0.783
PLK4PLK4 0.740 -0.024 2 0.645
PKACAPKACA 0.740 0.020 -2 0.661
FAM20CFAM20C 0.740 0.006 2 0.648
PKCTPKCT 0.740 -0.001 2 0.755
AKT1AKT1 0.740 0.015 -3 0.552
TTBK2TTBK2 0.740 -0.172 2 0.742
WNK4WNK4 0.739 -0.022 -2 0.868
MPSK1MPSK1 0.739 0.112 1 0.480
DRAK1DRAK1 0.739 -0.058 1 0.501
PKCIPKCI 0.739 0.029 2 0.781
PINK1PINK1 0.739 0.044 1 0.622
MST3MST3 0.739 0.041 2 0.866
VRK2VRK2 0.739 -0.017 1 0.581
ACVR2AACVR2A 0.738 -0.041 -2 0.782
DLKDLK 0.738 -0.234 1 0.530
ACVR2BACVR2B 0.738 -0.044 -2 0.787
PIM2PIM2 0.737 -0.015 -3 0.580
YSK4YSK4 0.737 -0.118 1 0.467
CHK1CHK1 0.737 -0.058 -3 0.644
GRK4GRK4 0.737 -0.170 -2 0.803
TAO3TAO3 0.737 0.044 1 0.515
AURAAURA 0.736 0.001 -2 0.663
ALK2ALK2 0.736 -0.032 -2 0.806
CAMK1GCAMK1G 0.736 -0.055 -3 0.581
BMPR1ABMPR1A 0.736 0.008 1 0.511
PLK1PLK1 0.736 -0.132 -2 0.766
GSK3AGSK3A 0.736 0.119 4 0.451
SMMLCKSMMLCK 0.735 -0.009 -3 0.627
PKCEPKCE 0.735 0.033 2 0.755
PHKG2PHKG2 0.735 -0.045 -3 0.642
DCAMKL2DCAMKL2 0.734 -0.026 -3 0.632
PAK2PAK2 0.734 -0.073 -2 0.760
CHAK1CHAK1 0.733 -0.146 2 0.773
SSTKSSTK 0.732 -0.027 4 0.806
MEKK3MEKK3 0.732 -0.086 1 0.500
SGK1SGK1 0.732 0.033 -3 0.467
ZAKZAK 0.732 -0.086 1 0.480
PERKPERK 0.731 -0.105 -2 0.821
MLK4MLK4 0.731 -0.126 2 0.768
SMG1SMG1 0.731 -0.106 1 0.472
MEKK2MEKK2 0.730 -0.052 2 0.820
MEK5MEK5 0.730 -0.117 2 0.841
GRK2GRK2 0.730 -0.073 -2 0.699
MEKK1MEKK1 0.730 -0.092 1 0.485
PKN1PKN1 0.730 -0.021 -3 0.572
MAPKAPK5MAPKAPK5 0.730 -0.132 -3 0.541
BRAFBRAF 0.729 -0.099 -4 0.698
SNRKSNRK 0.729 -0.156 2 0.687
TLK2TLK2 0.729 -0.124 1 0.453
AKT3AKT3 0.729 0.008 -3 0.474
PAK5PAK5 0.728 -0.017 -2 0.642
P70S6KP70S6K 0.728 -0.060 -3 0.551
HRIHRI 0.728 -0.152 -2 0.824
CAMK1DCAMK1D 0.727 -0.049 -3 0.542
IRAK4IRAK4 0.727 -0.111 1 0.449
CK1ECK1E 0.726 -0.064 -3 0.313
GAKGAK 0.726 0.002 1 0.529
NEK5NEK5 0.726 -0.131 1 0.476
TAO2TAO2 0.726 -0.008 2 0.854
PLK3PLK3 0.726 -0.143 2 0.800
GSK3BGSK3B 0.725 0.023 4 0.444
PDK1PDK1 0.724 -0.025 1 0.500
PAK4PAK4 0.724 -0.011 -2 0.653
SBKSBK 0.724 0.041 -3 0.447
TNIKTNIK 0.723 0.025 3 0.795
DAPK3DAPK3 0.723 -0.022 -3 0.608
HPK1HPK1 0.723 0.014 1 0.505
MRCKBMRCKB 0.723 0.004 -3 0.588
GCKGCK 0.722 -0.012 1 0.512
MEKK6MEKK6 0.722 0.007 1 0.485
NEK11NEK11 0.722 -0.084 1 0.505
TLK1TLK1 0.721 -0.146 -2 0.810
MAP3K15MAP3K15 0.721 0.005 1 0.473
MINKMINK 0.721 -0.003 1 0.474
KHS2KHS2 0.720 0.055 1 0.503
ROCK2ROCK2 0.720 0.012 -3 0.618
PASKPASK 0.720 -0.081 -3 0.612
KHS1KHS1 0.720 0.032 1 0.480
HGKHGK 0.720 -0.015 3 0.799
CHK2CHK2 0.719 -0.045 -3 0.502
CK1G1CK1G1 0.719 -0.083 -3 0.327
CK1DCK1D 0.718 -0.059 -3 0.284
NEK8NEK8 0.718 -0.145 2 0.833
MRCKAMRCKA 0.718 -0.012 -3 0.599
LRRK2LRRK2 0.718 -0.008 2 0.863
HASPINHASPIN 0.718 0.019 -1 0.585
NEK4NEK4 0.717 -0.101 1 0.461
DAPK1DAPK1 0.717 -0.028 -3 0.583
CAMK1ACAMK1A 0.717 -0.043 -3 0.519
IRAK1IRAK1 0.717 -0.197 -1 0.563
TTBK1TTBK1 0.716 -0.158 2 0.653
LKB1LKB1 0.716 -0.104 -3 0.615
YSK1YSK1 0.716 0.011 2 0.826
LOKLOK 0.716 -0.064 -2 0.764
GRK3GRK3 0.715 -0.080 -2 0.664
MST2MST2 0.715 -0.085 1 0.495
DMPK1DMPK1 0.714 0.029 -3 0.606
EEF2KEEF2K 0.714 -0.043 3 0.763
CAMKK2CAMKK2 0.713 -0.136 -2 0.715
NEK1NEK1 0.713 -0.087 1 0.462
CAMKK1CAMKK1 0.713 -0.166 -2 0.704
CK1A2CK1A2 0.713 -0.077 -3 0.282
PDHK3_TYRPDHK3_TYR 0.713 0.088 4 0.856
PBKPBK 0.712 -0.022 1 0.461
CK2A2CK2A2 0.712 -0.055 1 0.459
PKMYT1_TYRPKMYT1_TYR 0.712 0.196 3 0.791
SLKSLK 0.712 -0.073 -2 0.712
PKG1PKG1 0.711 -0.030 -2 0.632
MST1MST1 0.710 -0.095 1 0.479
MEK2MEK2 0.708 -0.090 2 0.821
ROCK1ROCK1 0.708 -0.003 -3 0.599
TAK1TAK1 0.707 -0.129 1 0.485
VRK1VRK1 0.707 -0.117 2 0.838
LIMK2_TYRLIMK2_TYR 0.707 0.060 -3 0.698
NEK3NEK3 0.706 -0.071 1 0.452
STK33STK33 0.706 -0.130 2 0.639
MAP2K4_TYRMAP2K4_TYR 0.705 0.018 -1 0.674
TESK1_TYRTESK1_TYR 0.705 -0.032 3 0.802
BUB1BUB1 0.704 -0.040 -5 0.768
CK2A1CK2A1 0.703 -0.061 1 0.452
BMPR2_TYRBMPR2_TYR 0.703 0.016 -1 0.623
MAP2K7_TYRMAP2K7_TYR 0.703 -0.055 2 0.863
PDHK4_TYRPDHK4_TYR 0.702 -0.016 2 0.882
RIPK2RIPK2 0.702 -0.199 1 0.437
MAP2K6_TYRMAP2K6_TYR 0.702 -0.005 -1 0.666
CRIKCRIK 0.701 -0.018 -3 0.548
TAO1TAO1 0.701 -0.034 1 0.444
MYO3BMYO3B 0.700 -0.006 2 0.835
BIKEBIKE 0.699 -0.017 1 0.447
LIMK1_TYRLIMK1_TYR 0.699 -0.011 2 0.849
PINK1_TYRPINK1_TYR 0.698 -0.114 1 0.543
PDHK1_TYRPDHK1_TYR 0.697 -0.082 -1 0.652
MYO3AMYO3A 0.697 -0.020 1 0.475
OSR1OSR1 0.696 -0.080 2 0.819
PLK2PLK2 0.696 -0.121 -3 0.508
ASK1ASK1 0.695 -0.076 1 0.467
TNNI3K_TYRTNNI3K_TYR 0.694 0.012 1 0.505
TTKTTK 0.694 -0.097 -2 0.797
TYK2TYK2 0.692 -0.136 1 0.485
AAK1AAK1 0.692 0.019 1 0.398
MST1RMST1R 0.692 -0.126 3 0.789
JAK2JAK2 0.691 -0.103 1 0.506
ROS1ROS1 0.690 -0.124 3 0.756
RETRET 0.690 -0.199 1 0.501
CSF1RCSF1R 0.690 -0.114 3 0.778
DDR1DDR1 0.688 -0.135 4 0.776
JAK1JAK1 0.688 -0.030 1 0.456
TNK1TNK1 0.686 -0.073 3 0.748
TYRO3TYRO3 0.686 -0.194 3 0.770
EPHA6EPHA6 0.685 -0.128 -1 0.537
ABL2ABL2 0.685 -0.119 -1 0.556
TXKTXK 0.684 -0.081 1 0.534
TNK2TNK2 0.683 -0.116 3 0.742
NEK10_TYRNEK10_TYR 0.683 -0.101 1 0.417
CK1ACK1A 0.683 -0.085 -3 0.210
JAK3JAK3 0.682 -0.169 1 0.485
YES1YES1 0.681 -0.137 -1 0.571
ABL1ABL1 0.681 -0.127 -1 0.554
INSRRINSRR 0.681 -0.154 3 0.723
FGRFGR 0.680 -0.181 1 0.509
FGFR2FGFR2 0.680 -0.131 3 0.746
FGFR1FGFR1 0.680 -0.103 3 0.742
KDRKDR 0.680 -0.129 3 0.745
EPHB4EPHB4 0.679 -0.187 -1 0.523
TEKTEK 0.679 -0.092 3 0.698
PDGFRBPDGFRB 0.679 -0.192 3 0.786
ITKITK 0.679 -0.137 -1 0.508
WEE1_TYRWEE1_TYR 0.679 -0.074 -1 0.539
KITKIT 0.678 -0.151 3 0.768
EPHA4EPHA4 0.678 -0.100 2 0.796
SRMSSRMS 0.678 -0.160 1 0.520
FLT3FLT3 0.677 -0.170 3 0.763
FERFER 0.677 -0.209 1 0.531
YANK3YANK3 0.676 -0.082 2 0.429
AXLAXL 0.676 -0.177 3 0.756
ALPHAK3ALPHAK3 0.676 -0.141 -1 0.562
HCKHCK 0.675 -0.171 -1 0.517
BLKBLK 0.675 -0.099 -1 0.525
LCKLCK 0.675 -0.133 -1 0.514
DDR2DDR2 0.674 -0.070 3 0.719
EPHB1EPHB1 0.674 -0.184 1 0.514
STLK3STLK3 0.673 -0.182 1 0.453
MERTKMERTK 0.673 -0.168 3 0.742
TECTEC 0.673 -0.148 -1 0.460
METMET 0.672 -0.156 3 0.762
PDGFRAPDGFRA 0.672 -0.208 3 0.790
BMXBMX 0.672 -0.125 -1 0.437
EPHB3EPHB3 0.670 -0.195 -1 0.493
FGFR3FGFR3 0.670 -0.135 3 0.724
EPHB2EPHB2 0.669 -0.178 -1 0.492
FLT1FLT1 0.668 -0.173 -1 0.548
BTKBTK 0.668 -0.220 -1 0.486
ALKALK 0.667 -0.191 3 0.715
NTRK1NTRK1 0.667 -0.208 -1 0.550
FLT4FLT4 0.667 -0.174 3 0.724
MATKMATK 0.667 -0.121 -1 0.534
ERBB2ERBB2 0.666 -0.177 1 0.487
PTK2BPTK2B 0.666 -0.119 -1 0.507
NTRK2NTRK2 0.666 -0.213 3 0.752
FYNFYN 0.665 -0.124 -1 0.487
EPHA7EPHA7 0.665 -0.151 2 0.798
NTRK3NTRK3 0.665 -0.159 -1 0.509
LTKLTK 0.665 -0.195 3 0.725
INSRINSR 0.664 -0.181 3 0.705
FRKFRK 0.664 -0.170 -1 0.526
EGFREGFR 0.663 -0.114 1 0.441
EPHA1EPHA1 0.662 -0.192 3 0.746
EPHA3EPHA3 0.662 -0.166 2 0.766
PTK6PTK6 0.661 -0.240 -1 0.486
LYNLYN 0.661 -0.168 3 0.707
PTK2PTK2 0.659 -0.077 -1 0.461
SRCSRC 0.658 -0.151 -1 0.504
FGFR4FGFR4 0.658 -0.129 -1 0.512
CSKCSK 0.657 -0.173 2 0.796
EPHA8EPHA8 0.656 -0.149 -1 0.473
MUSKMUSK 0.656 -0.135 1 0.404
EPHA5EPHA5 0.655 -0.168 2 0.782
CK1G3CK1G3 0.655 -0.115 -3 0.176
SYKSYK 0.654 -0.111 -1 0.461
EPHA2EPHA2 0.651 -0.136 -1 0.436
ERBB4ERBB4 0.649 -0.111 1 0.458
IGF1RIGF1R 0.648 -0.171 3 0.639
YANK2YANK2 0.643 -0.106 2 0.443
FESFES 0.642 -0.138 -1 0.431
ZAP70ZAP70 0.639 -0.098 -1 0.440
CK1G2CK1G2 0.633 -0.116 -3 0.255