Motif 786 (n=139)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S686 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A6ND36 | FAM83G | S365 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A6NKT7 | RGPD3 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NMY6 | ANXA2P2 | S314 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| O14715 | RGPD8 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43680 | TCF21 | S67 | ochoa | Transcription factor 21 (TCF-21) (Capsulin) (Class A basic helix-loop-helix protein 23) (bHLHa23) (Epicardin) (Podocyte-expressed 1) (Pod-1) | Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types. |
| O43776 | NARS1 | S88 | ochoa | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) | Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}. |
| O60814 | H2BC12 | S37 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O60841 | EIF5B | S214 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75475 | PSIP1 | S482 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O95149 | SNUPN | S329 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| O95279 | KCNK5 | S270 | ochoa | Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}. |
| P04049 | RAF1 | S339 | psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04350 | TUBB4A | S339 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04406 | GAPDH | S151 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P05067 | APP | S441 | ochoa | Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: [Amyloid-beta protein 42]: More effective reductant than amyloid-beta protein 40. May activate mononuclear phagocytes in the brain and elicit inflammatory responses.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. |
| P07355 | ANXA2 | S314 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07437 | TUBB | S339 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P09467 | FBP1 | S63 | psp | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P0DJD0 | RGPD1 | S962 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S970 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P11021 | HSPA5 | S365 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P11137 | MAP2 | S1158 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P13569 | CFTR | S700 | ochoa|psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
| P15924 | DSP | S2792 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16333 | NCK1 | S347 | ochoa | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}. |
| P16435 | POR | S68 | ochoa | NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) | This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP-Rule:MF_03212}. |
| P16615 | ATP2A2 | S504 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P23497 | SP100 | S231 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P23769 | GATA2 | S220 | ochoa | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
| P24941 | CDK2 | S46 | psp | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}. |
| P25440 | BRD2 | S341 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P27816 | MAP4 | S1058 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P34972 | CNR2 | S335 | ochoa|psp | Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5) | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}. |
| P35749 | MYH11 | S209 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P46821 | MAP1B | S582 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48729 | CSNK1A1 | S242 | psp | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. |
| P49792 | RANBP2 | S1953 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51955 | NEK2 | S397 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P53985 | SLC16A1 | S213 | ochoa | Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) | Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023). {ECO:0000250|UniProtKB:P53986, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:33333023}. |
| P54577 | YARS1 | S358 | ochoa | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). {ECO:0000269|PubMed:25533949, ECO:0000305|PubMed:16429158, ECO:0000305|PubMed:9162081}. |
| P54577 | YARS1 | S386 | ochoa | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). {ECO:0000269|PubMed:25533949, ECO:0000305|PubMed:16429158, ECO:0000305|PubMed:9162081}. |
| P57053 | H2BC12L | S37 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | S37 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62241 | RPS8 | S159 | ochoa | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62241 | RPS8 | S160 | ochoa | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62807 | H2BC4 | S37 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P68371 | TUBB4B | S339 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78368 | CSNK1G2 | S366 | ochoa | Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}. |
| P78527 | PRKDC | S4026 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q01105 | SET | S166 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01995 | TAGLN | S166 | ochoa | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}. |
| Q02241 | KIF23 | S298 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02241 | KIF23 | S889 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q03164 | KMT2A | S261 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S1056 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q06265 | EXOSC9 | S287 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q08945 | SSRP1 | S652 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q09666 | AHNAK | S1123 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12802 | AKAP13 | S1856 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12929 | EPS8 | S481 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13509 | TUBB3 | S339 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13813 | SPTAN1 | S1990 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13885 | TUBB2A | S339 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14126 | DSG2 | S551 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14155 | ARHGEF7 | S694 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14247 | CTTN | S47 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q15052 | ARHGEF6 | S640 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15149 | PLEC | S4590 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q16778 | H2BC21 | S37 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q53GQ0 | HSD17B12 | S92 | ochoa | Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1) | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}. |
| Q5SSJ5 | HP1BP3 | S248 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5VT52 | RPRD2 | S864 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q69YN4 | VIRMA | S1603 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6DN03 | H2BC20P | S37 | ochoa | Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DRA6 | H2BC19P | S37 | ochoa | Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6GYQ0 | RALGAPA1 | S721 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6ZSR9 | None | S157 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q76FK4 | NOL8 | S421 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7Z3J3 | RGPD4 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q8IUC4 | RHPN2 | S639 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8N257 | H2BC26 | S37 | ochoa | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8N4S0 | CCDC82 | S220 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8N9B5 | JMY | S889 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NEV8 | EXPH5 | S1236 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NG08 | HELB | S405 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8TD26 | CHD6 | S1360 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TEY7 | USP33 | S377 | ochoa | Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}. |
| Q8WUM9 | SLC20A1 | S269 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q92541 | RTF1 | S650 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q93079 | H2BC9 | S37 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96BY6 | DOCK10 | S1318 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96FQ6 | S100A16 | S37 | ochoa | Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16) | Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). {ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}. |
| Q96GA3 | LTV1 | S380 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96H22 | CENPN | S282 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96MY1 | NOL4L | S294 | ochoa | Nucleolar protein 4-like | None |
| Q99504 | EYA3 | S297 | ochoa | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q99666 | RGPD5 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99704 | DOK1 | S269 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q99877 | H2BC15 | S37 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | S37 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | S37 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BUF5 | TUBB6 | S339 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S339 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BXY4 | RSPO3 | S241 | ochoa | R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720). {ECO:0000250|UniProtKB:Q2TJ95, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:29769720}. |
| Q9H583 | HEATR1 | S516 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9NR30 | DDX21 | S567 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NR80 | ARHGEF4 | S112 | ochoa | Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}. |
| Q9NU19 | TBC1D22B | S57 | ochoa | TBC1 domain family member 22B | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q9P289 | STK26 | S282 | ochoa | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}. |
| Q9UHF7 | TRPS1 | S389 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UI36 | DACH1 | S581 | psp | Dachshund homolog 1 (Dach1) | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}. |
| Q9UKJ3 | GPATCH8 | S1107 | ochoa | G patch domain-containing protein 8 | None |
| Q9ULF5 | SLC39A10 | S539 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9Y3B9 | RRP15 | S220 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y485 | DMXL1 | S2381 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y520 | PRRC2C | S376 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5K6 | CD2AP | S233 | ochoa|psp | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y6E0 | STK24 | S294 | ochoa | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| Q9Y6T7 | DGKB | S420 | ochoa | Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:P49621, ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269|PubMed:11719522}. |
| Q9Y6X9 | MORC2 | S779 | ochoa | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| Q5QNW6 | H2BC18 | S37 | Sugiyama | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P46782 | RPS5 | S75 | Sugiyama | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P43246 | MSH2 | S558 | Sugiyama | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:26300262, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| Q8WVM8 | SCFD1 | S340 | Sugiyama | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| P06899 | H2BC11 | S37 | Sugiyama | Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P23527 | H2BC17 | S37 | Sugiyama | Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P33778 | H2BC3 | S37 | Sugiyama | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P31947 | SFN | S149 | Sugiyama | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P33778 | H2BC3 | S33 | EPSD | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62807 | H2BC4 | S33 | ELM | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P49736 | MCM2 | S754 | Sugiyama | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| Q6PID6 | TTC33 | S19 | Sugiyama | Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor) | None |
| O43930 | PRKY | S81 | Sugiyama | Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1) | None |
| P51817 | PRKX | S81 | Sugiyama | cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) | Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}. |
| Q12778 | FOXO1 | S212 | GPS6|SIGNOR|EPSD|PSP | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q6PHR2 | ULK3 | S339 | Sugiyama | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| Q8IU85 | CAMK1D | S64 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| P43246 | MSH2 | S540 | Sugiyama | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:26300262, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-171306 | Packaging Of Telomere Ends | 1.110223e-16 | 15.955 |
| R-HSA-5334118 | DNA methylation | 1.110223e-16 | 15.955 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.110223e-16 | 15.955 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.110223e-16 | 15.955 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.110223e-16 | 15.955 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.110223e-16 | 15.955 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.110223e-16 | 15.955 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.110223e-16 | 15.955 |
| R-HSA-774815 | Nucleosome assembly | 2.220446e-16 | 15.654 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.220446e-16 | 15.654 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.330669e-16 | 15.477 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.330669e-16 | 15.477 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.551115e-16 | 15.256 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.551115e-16 | 15.256 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 7.771561e-16 | 15.109 |
| R-HSA-110331 | Cleavage of the damaged purine | 7.771561e-16 | 15.109 |
| R-HSA-912446 | Meiotic recombination | 1.110223e-15 | 14.955 |
| R-HSA-73927 | Depurination | 9.992007e-16 | 15.000 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.665335e-15 | 14.778 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.665335e-15 | 14.778 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.665335e-15 | 14.778 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 2.220446e-15 | 14.654 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.220446e-15 | 14.654 |
| R-HSA-9609690 | HCMV Early Events | 2.442491e-15 | 14.612 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.663736e-15 | 14.436 |
| R-HSA-73928 | Depyrimidination | 3.663736e-15 | 14.436 |
| R-HSA-9710421 | Defective pyroptosis | 4.662937e-15 | 14.331 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.884182e-15 | 14.230 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.065814e-14 | 13.972 |
| R-HSA-68886 | M Phase | 1.454392e-14 | 13.837 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.164935e-14 | 13.665 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.253753e-14 | 13.647 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.697842e-14 | 13.569 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.219647e-14 | 13.492 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.608225e-14 | 13.443 |
| R-HSA-1221632 | Meiotic synapsis | 4.440892e-14 | 13.353 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.596323e-14 | 13.338 |
| R-HSA-69481 | G2/M Checkpoints | 5.229150e-14 | 13.282 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.406786e-14 | 13.267 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.440093e-14 | 13.264 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.394885e-14 | 13.194 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.650236e-14 | 13.177 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.750156e-14 | 13.171 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 8.892886e-14 | 13.051 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.078027e-13 | 12.967 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.187939e-13 | 12.925 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.724176e-13 | 12.763 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.724176e-13 | 12.763 |
| R-HSA-9609646 | HCMV Infection | 1.901812e-13 | 12.721 |
| R-HSA-977225 | Amyloid fiber formation | 2.646772e-13 | 12.577 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.646772e-13 | 12.577 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.924327e-13 | 12.534 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.069767e-13 | 12.513 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.297362e-13 | 12.482 |
| R-HSA-1640170 | Cell Cycle | 3.353984e-13 | 12.474 |
| R-HSA-1500620 | Meiosis | 4.742873e-13 | 12.324 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 8.995027e-13 | 12.046 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 9.466872e-13 | 12.024 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 9.466872e-13 | 12.024 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.108225e-12 | 11.955 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.364220e-12 | 11.626 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.159140e-12 | 11.500 |
| R-HSA-157579 | Telomere Maintenance | 3.411826e-12 | 11.467 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.191758e-12 | 11.378 |
| R-HSA-68875 | Mitotic Prophase | 4.356404e-12 | 11.361 |
| R-HSA-73886 | Chromosome Maintenance | 4.831580e-12 | 11.316 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.176504e-12 | 11.209 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.146427e-11 | 10.941 |
| R-HSA-69306 | DNA Replication | 1.146427e-11 | 10.941 |
| R-HSA-211000 | Gene Silencing by RNA | 1.214540e-11 | 10.916 |
| R-HSA-73884 | Base Excision Repair | 1.774347e-11 | 10.751 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.005829e-11 | 10.698 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.304634e-11 | 10.637 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.556033e-11 | 10.592 |
| R-HSA-8852135 | Protein ubiquitination | 3.672318e-11 | 10.435 |
| R-HSA-5693538 | Homology Directed Repair | 4.672163e-11 | 10.330 |
| R-HSA-3214847 | HATs acetylate histones | 6.390521e-11 | 10.194 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.553635e-11 | 10.122 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.850976e-11 | 10.053 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.214691e-10 | 9.916 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.214691e-10 | 9.916 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.286606e-10 | 9.891 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.359425e-10 | 9.867 |
| R-HSA-1474165 | Reproduction | 1.712606e-10 | 9.766 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.606181e-10 | 9.584 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.621146e-10 | 9.250 |
| R-HSA-1500931 | Cell-Cell communication | 5.987013e-10 | 9.223 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.030633e-10 | 9.220 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.154740e-09 | 8.938 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.154740e-09 | 8.938 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.154740e-09 | 8.938 |
| R-HSA-9610379 | HCMV Late Events | 1.714747e-09 | 8.766 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.415407e-09 | 8.617 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 3.271223e-09 | 8.485 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.299640e-09 | 8.482 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.495608e-09 | 8.456 |
| R-HSA-2559583 | Cellular Senescence | 8.549658e-09 | 8.068 |
| R-HSA-9646399 | Aggrephagy | 2.124861e-08 | 7.673 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.416050e-08 | 7.466 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.616774e-08 | 7.336 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.616774e-08 | 7.336 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.628136e-08 | 7.335 |
| R-HSA-5688426 | Deubiquitination | 6.788429e-08 | 7.168 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.110985e-08 | 7.148 |
| R-HSA-195721 | Signaling by WNT | 7.233672e-08 | 7.141 |
| R-HSA-1266738 | Developmental Biology | 8.565028e-08 | 7.067 |
| R-HSA-9824446 | Viral Infection Pathways | 9.961601e-08 | 7.002 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.162634e-07 | 6.935 |
| R-HSA-73894 | DNA Repair | 1.449558e-07 | 6.839 |
| R-HSA-190861 | Gap junction assembly | 1.624256e-07 | 6.789 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.670580e-07 | 6.777 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.674369e-07 | 6.776 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.787652e-07 | 6.748 |
| R-HSA-446728 | Cell junction organization | 1.882975e-07 | 6.725 |
| R-HSA-157118 | Signaling by NOTCH | 2.212441e-07 | 6.655 |
| R-HSA-4839726 | Chromatin organization | 3.314155e-07 | 6.480 |
| R-HSA-983189 | Kinesins | 3.454015e-07 | 6.462 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.144856e-07 | 6.382 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.222514e-07 | 6.374 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.513912e-07 | 6.345 |
| R-HSA-2262752 | Cellular responses to stress | 4.836798e-07 | 6.315 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 5.135074e-07 | 6.289 |
| R-HSA-418990 | Adherens junctions interactions | 5.204779e-07 | 6.284 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.311991e-07 | 6.275 |
| R-HSA-190828 | Gap junction trafficking | 7.864692e-07 | 6.104 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.137557e-06 | 5.944 |
| R-HSA-437239 | Recycling pathway of L1 | 1.137557e-06 | 5.944 |
| R-HSA-8939211 | ESR-mediated signaling | 1.212609e-06 | 5.916 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.263049e-06 | 5.899 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.437950e-06 | 5.842 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.477443e-06 | 5.830 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.570204e-06 | 5.804 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.711957e-06 | 5.767 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.993532e-06 | 5.700 |
| R-HSA-421270 | Cell-cell junction organization | 2.159371e-06 | 5.666 |
| R-HSA-9833482 | PKR-mediated signaling | 2.319203e-06 | 5.635 |
| R-HSA-162582 | Signal Transduction | 2.645170e-06 | 5.578 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.726794e-06 | 5.564 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.764182e-06 | 5.558 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.831799e-06 | 5.548 |
| R-HSA-9663891 | Selective autophagy | 4.706825e-06 | 5.327 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.470648e-06 | 5.262 |
| R-HSA-68877 | Mitotic Prometaphase | 6.505470e-06 | 5.187 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.534220e-06 | 5.185 |
| R-HSA-1280218 | Adaptive Immune System | 8.100756e-06 | 5.091 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 9.281817e-06 | 5.032 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 9.534208e-06 | 5.021 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.534208e-06 | 5.021 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.188842e-05 | 4.925 |
| R-HSA-75153 | Apoptotic execution phase | 1.450663e-05 | 4.838 |
| R-HSA-5620924 | Intraflagellar transport | 1.776743e-05 | 4.750 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.357867e-05 | 4.627 |
| R-HSA-69275 | G2/M Transition | 2.905976e-05 | 4.537 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.132857e-05 | 4.504 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.151539e-05 | 4.501 |
| R-HSA-373760 | L1CAM interactions | 3.774512e-05 | 4.423 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.307118e-05 | 4.366 |
| R-HSA-5663205 | Infectious disease | 5.346650e-05 | 4.272 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.433612e-05 | 4.265 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.615780e-05 | 4.179 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.878033e-05 | 4.104 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.241496e-05 | 4.034 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.000761e-04 | 4.000 |
| R-HSA-422475 | Axon guidance | 1.000859e-04 | 4.000 |
| R-HSA-373753 | Nephrin family interactions | 1.033827e-04 | 3.986 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.265732e-04 | 3.898 |
| R-HSA-913531 | Interferon Signaling | 1.332049e-04 | 3.875 |
| R-HSA-1632852 | Macroautophagy | 1.441052e-04 | 3.841 |
| R-HSA-5617833 | Cilium Assembly | 1.854437e-04 | 3.732 |
| R-HSA-9675108 | Nervous system development | 2.046757e-04 | 3.689 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.313895e-04 | 3.480 |
| R-HSA-9612973 | Autophagy | 2.748570e-04 | 3.561 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.786863e-04 | 3.555 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.954881e-04 | 3.403 |
| R-HSA-68882 | Mitotic Anaphase | 4.468833e-04 | 3.350 |
| R-HSA-391251 | Protein folding | 4.553091e-04 | 3.342 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.605564e-04 | 3.337 |
| R-HSA-597592 | Post-translational protein modification | 4.673163e-04 | 3.330 |
| R-HSA-109582 | Hemostasis | 6.329338e-04 | 3.199 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.215492e-03 | 2.915 |
| R-HSA-109581 | Apoptosis | 1.725157e-03 | 2.763 |
| R-HSA-74160 | Gene expression (Transcription) | 1.726878e-03 | 2.763 |
| R-HSA-392499 | Metabolism of proteins | 1.877151e-03 | 2.727 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.825373e-03 | 2.549 |
| R-HSA-1643685 | Disease | 3.015637e-03 | 2.521 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.344705e-03 | 2.476 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 3.390543e-03 | 2.470 |
| R-HSA-212436 | Generic Transcription Pathway | 3.444736e-03 | 2.463 |
| R-HSA-199991 | Membrane Trafficking | 4.608184e-03 | 2.336 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.816507e-03 | 2.317 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.816507e-03 | 2.317 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 5.002825e-03 | 2.301 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 5.002825e-03 | 2.301 |
| R-HSA-68962 | Activation of the pre-replicative complex | 5.003502e-03 | 2.301 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.258784e-03 | 2.279 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.558788e-03 | 2.255 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.562082e-03 | 2.255 |
| R-HSA-5357801 | Programmed Cell Death | 5.809107e-03 | 2.236 |
| R-HSA-176974 | Unwinding of DNA | 5.917228e-03 | 2.228 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 5.917228e-03 | 2.228 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 6.232526e-03 | 2.205 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 6.381071e-03 | 2.195 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.592377e-03 | 2.120 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.592377e-03 | 2.120 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 7.955538e-03 | 2.099 |
| R-HSA-380287 | Centrosome maturation | 8.251053e-03 | 2.083 |
| R-HSA-428540 | Activation of RAC1 | 9.076698e-03 | 2.042 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 9.076698e-03 | 2.042 |
| R-HSA-416482 | G alpha (12/13) signalling events | 9.307585e-03 | 2.031 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.492812e-03 | 2.023 |
| R-HSA-168256 | Immune System | 1.086079e-02 | 1.964 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.151630e-02 | 1.939 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.167652e-02 | 1.933 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.430055e-02 | 1.845 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.489199e-02 | 1.827 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.553740e-02 | 1.809 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.714816e-02 | 1.766 |
| R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 | 1.870254e-02 | 1.728 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 1.870254e-02 | 1.728 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.967849e-02 | 1.706 |
| R-HSA-3928664 | Ephrin signaling | 2.032024e-02 | 1.692 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.098474e-02 | 1.678 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 2.792308e-02 | 1.554 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.418923e-02 | 1.616 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.027725e-02 | 1.519 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.575743e-02 | 1.589 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.732834e-02 | 1.563 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.312907e-02 | 1.480 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.312907e-02 | 1.480 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.541308e-02 | 1.595 |
| R-HSA-72312 | rRNA processing | 3.319339e-02 | 1.479 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 3.705755e-02 | 1.431 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 3.705755e-02 | 1.431 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.936354e-02 | 1.405 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.936354e-02 | 1.405 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.204129e-02 | 1.376 |
| R-HSA-112316 | Neuronal System | 4.324598e-02 | 1.364 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 4.610674e-02 | 1.336 |
| R-HSA-186763 | Downstream signal transduction | 4.830194e-02 | 1.316 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.866427e-02 | 1.313 |
| R-HSA-69190 | DNA strand elongation | 5.064158e-02 | 1.295 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 5.507145e-02 | 1.259 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 5.507145e-02 | 1.259 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.789713e-02 | 1.237 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.037403e-02 | 1.219 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 6.039140e-02 | 1.219 |
| R-HSA-381042 | PERK regulates gene expression | 6.039140e-02 | 1.219 |
| R-HSA-68911 | G2 Phase | 6.395246e-02 | 1.194 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 6.548814e-02 | 1.184 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 7.275054e-02 | 1.138 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 7.275054e-02 | 1.138 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 7.275054e-02 | 1.138 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.275054e-02 | 1.138 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.300337e-02 | 1.137 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 7.339052e-02 | 1.134 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.585555e-02 | 1.120 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.843112e-02 | 1.106 |
| R-HSA-73887 | Death Receptor Signaling | 8.105012e-02 | 1.091 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 8.146646e-02 | 1.089 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 8.146646e-02 | 1.089 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 8.146646e-02 | 1.089 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 8.158120e-02 | 1.088 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 9.010100e-02 | 1.045 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 9.010100e-02 | 1.045 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.865489e-02 | 1.006 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 9.865489e-02 | 1.006 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 9.865489e-02 | 1.006 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.238402e-01 | 0.907 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.238402e-01 | 0.907 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.238402e-01 | 0.907 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.320789e-01 | 0.879 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.320789e-01 | 0.879 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.402407e-01 | 0.853 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.483263e-01 | 0.829 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.642714e-01 | 0.784 |
| R-HSA-72649 | Translation initiation complex formation | 1.168013e-01 | 0.933 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.229957e-01 | 0.910 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.055849e-01 | 0.976 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.320789e-01 | 0.879 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.402407e-01 | 0.853 |
| R-HSA-162592 | Integration of provirus | 1.320789e-01 | 0.879 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.257480e-01 | 0.900 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.257480e-01 | 0.900 |
| R-HSA-4839744 | Signaling by APC mutants | 1.238402e-01 | 0.907 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.320789e-01 | 0.879 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.320789e-01 | 0.879 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.402407e-01 | 0.853 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.483263e-01 | 0.829 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.642714e-01 | 0.784 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.106904e-01 | 0.956 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.137351e-01 | 0.944 |
| R-HSA-191859 | snRNP Assembly | 1.324324e-01 | 0.878 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.324324e-01 | 0.878 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.642714e-01 | 0.784 |
| R-HSA-69206 | G1/S Transition | 1.471720e-01 | 0.832 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 9.865489e-02 | 1.006 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.071289e-01 | 0.970 |
| R-HSA-164843 | 2-LTR circle formation | 1.155237e-01 | 0.937 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.320789e-01 | 0.879 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.320789e-01 | 0.879 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.402407e-01 | 0.853 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 9.291268e-02 | 1.032 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.292683e-01 | 0.889 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.137351e-01 | 0.944 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.071289e-01 | 0.970 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 9.003817e-02 | 1.046 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 9.003817e-02 | 1.046 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 9.865489e-02 | 1.006 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.071289e-01 | 0.970 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.320789e-01 | 0.879 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.642714e-01 | 0.784 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.071289e-01 | 0.970 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.483263e-01 | 0.829 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.642714e-01 | 0.784 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.642714e-01 | 0.784 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.716136e-01 | 0.765 |
| R-HSA-69239 | Synthesis of DNA | 1.036445e-01 | 0.984 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.071289e-01 | 0.970 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.483263e-01 | 0.829 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.642714e-01 | 0.784 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.168013e-01 | 0.933 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.642714e-01 | 0.784 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.616338e-01 | 0.791 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.229957e-01 | 0.910 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.716136e-01 | 0.765 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.716136e-01 | 0.765 |
| R-HSA-70326 | Glucose metabolism | 1.278365e-01 | 0.893 |
| R-HSA-70263 | Gluconeogenesis | 9.874041e-02 | 1.006 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.642714e-01 | 0.784 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.311132e-01 | 0.882 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 1.682753e-01 | 0.774 |
| R-HSA-435354 | Zinc transporters | 1.563362e-01 | 0.806 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.452594e-01 | 0.838 |
| R-HSA-8848021 | Signaling by PTK6 | 1.452594e-01 | 0.838 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.238402e-01 | 0.907 |
| R-HSA-379724 | tRNA Aminoacylation | 1.356141e-01 | 0.868 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.017185e-01 | 0.993 |
| R-HSA-186797 | Signaling by PDGF | 1.420282e-01 | 0.848 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.378362e-01 | 0.861 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.517671e-01 | 0.819 |
| R-HSA-5635838 | Activation of SMO | 1.721324e-01 | 0.764 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 1.721324e-01 | 0.764 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.721324e-01 | 0.764 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.721324e-01 | 0.764 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.749630e-01 | 0.757 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.774366e-01 | 0.751 |
| R-HSA-397014 | Muscle contraction | 1.775059e-01 | 0.751 |
| R-HSA-9679506 | SARS-CoV Infections | 1.793148e-01 | 0.746 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.793629e-01 | 0.746 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 1.799199e-01 | 0.745 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.799199e-01 | 0.745 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.816928e-01 | 0.741 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.836450e-01 | 0.736 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.876347e-01 | 0.727 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.876347e-01 | 0.727 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.876347e-01 | 0.727 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.876347e-01 | 0.727 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.884608e-01 | 0.725 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.918580e-01 | 0.717 |
| R-HSA-5358508 | Mismatch Repair | 1.952774e-01 | 0.709 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.952774e-01 | 0.709 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.952774e-01 | 0.709 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.952774e-01 | 0.709 |
| R-HSA-9659379 | Sensory processing of sound | 1.986764e-01 | 0.702 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.027100e-01 | 0.693 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.028486e-01 | 0.693 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.028486e-01 | 0.693 |
| R-HSA-392517 | Rap1 signalling | 2.028486e-01 | 0.693 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.028486e-01 | 0.693 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.028486e-01 | 0.693 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.028486e-01 | 0.693 |
| R-HSA-69242 | S Phase | 2.075482e-01 | 0.683 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.079637e-01 | 0.682 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.103490e-01 | 0.677 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.103490e-01 | 0.677 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.173018e-01 | 0.663 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.177794e-01 | 0.662 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.177794e-01 | 0.662 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.177794e-01 | 0.662 |
| R-HSA-210991 | Basigin interactions | 2.177794e-01 | 0.662 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.227477e-01 | 0.652 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.227477e-01 | 0.652 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.246797e-01 | 0.648 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.251403e-01 | 0.648 |
| R-HSA-193048 | Androgen biosynthesis | 2.251403e-01 | 0.648 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.262072e-01 | 0.645 |
| R-HSA-162587 | HIV Life Cycle | 2.296258e-01 | 0.639 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.296707e-01 | 0.639 |
| R-HSA-156902 | Peptide chain elongation | 2.331379e-01 | 0.632 |
| R-HSA-877300 | Interferon gamma signaling | 2.345924e-01 | 0.630 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.370831e-01 | 0.625 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.396562e-01 | 0.620 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.435573e-01 | 0.613 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.468126e-01 | 0.608 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.468126e-01 | 0.608 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.468126e-01 | 0.608 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.470353e-01 | 0.607 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.505151e-01 | 0.601 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.505151e-01 | 0.601 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.539020e-01 | 0.595 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.609251e-01 | 0.583 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.609622e-01 | 0.583 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.644461e-01 | 0.578 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.644461e-01 | 0.578 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.678826e-01 | 0.572 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.678826e-01 | 0.572 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.678826e-01 | 0.572 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.678826e-01 | 0.572 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.747750e-01 | 0.561 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.747750e-01 | 0.561 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.747750e-01 | 0.561 |
| R-HSA-622312 | Inflammasomes | 2.747750e-01 | 0.561 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.747750e-01 | 0.561 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.774713e-01 | 0.557 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.783803e-01 | 0.555 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.816029e-01 | 0.550 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.816029e-01 | 0.550 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 2.816029e-01 | 0.550 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.816029e-01 | 0.550 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.818621e-01 | 0.550 |
| R-HSA-70171 | Glycolysis | 2.818621e-01 | 0.550 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.853426e-01 | 0.545 |
| R-HSA-168255 | Influenza Infection | 2.876868e-01 | 0.541 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.883669e-01 | 0.540 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.883669e-01 | 0.540 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.883669e-01 | 0.540 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.888215e-01 | 0.539 |
| R-HSA-8953854 | Metabolism of RNA | 2.901256e-01 | 0.537 |
| R-HSA-192823 | Viral mRNA Translation | 2.922986e-01 | 0.534 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.950677e-01 | 0.530 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.950677e-01 | 0.530 |
| R-HSA-182971 | EGFR downregulation | 2.950677e-01 | 0.530 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.957736e-01 | 0.529 |
| R-HSA-9833110 | RSV-host interactions | 2.992462e-01 | 0.524 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.017058e-01 | 0.520 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.017058e-01 | 0.520 |
| R-HSA-1538133 | G0 and Early G1 | 3.017058e-01 | 0.520 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.020667e-01 | 0.520 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.082818e-01 | 0.511 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.082818e-01 | 0.511 |
| R-HSA-9930044 | Nuclear RNA decay | 3.082818e-01 | 0.511 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.082818e-01 | 0.511 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.082818e-01 | 0.511 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.096470e-01 | 0.509 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.131075e-01 | 0.504 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.147963e-01 | 0.502 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.147963e-01 | 0.502 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.147963e-01 | 0.502 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.147963e-01 | 0.502 |
| R-HSA-5673000 | RAF activation | 3.212498e-01 | 0.493 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.212498e-01 | 0.493 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.212498e-01 | 0.493 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.269108e-01 | 0.486 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.269108e-01 | 0.486 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.276430e-01 | 0.485 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.276430e-01 | 0.485 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.339763e-01 | 0.476 |
| R-HSA-111933 | Calmodulin induced events | 3.339763e-01 | 0.476 |
| R-HSA-8853659 | RET signaling | 3.339763e-01 | 0.476 |
| R-HSA-111997 | CaM pathway | 3.339763e-01 | 0.476 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.339763e-01 | 0.476 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.402503e-01 | 0.468 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.440609e-01 | 0.463 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.464657e-01 | 0.460 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.464657e-01 | 0.460 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.526228e-01 | 0.453 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.526228e-01 | 0.453 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.526228e-01 | 0.453 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.526228e-01 | 0.453 |
| R-HSA-9648002 | RAS processing | 3.526228e-01 | 0.453 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.526228e-01 | 0.453 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.587223e-01 | 0.445 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.587223e-01 | 0.445 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.587223e-01 | 0.445 |
| R-HSA-167169 | HIV Transcription Elongation | 3.587223e-01 | 0.445 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.587223e-01 | 0.445 |
| R-HSA-202433 | Generation of second messenger molecules | 3.587223e-01 | 0.445 |
| R-HSA-3371556 | Cellular response to heat stress | 3.644545e-01 | 0.438 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.647648e-01 | 0.438 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.647648e-01 | 0.438 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.647648e-01 | 0.438 |
| R-HSA-9694548 | Maturation of spike protein | 3.647648e-01 | 0.438 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.707506e-01 | 0.431 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.707506e-01 | 0.431 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.707506e-01 | 0.431 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.707506e-01 | 0.431 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.707506e-01 | 0.431 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.707506e-01 | 0.431 |
| R-HSA-6809371 | Formation of the cornified envelope | 3.745631e-01 | 0.426 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.745631e-01 | 0.426 |
| R-HSA-111996 | Ca-dependent events | 3.766805e-01 | 0.424 |
| R-HSA-194138 | Signaling by VEGF | 3.812664e-01 | 0.419 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 3.825548e-01 | 0.417 |
| R-HSA-114608 | Platelet degranulation | 3.879395e-01 | 0.411 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.883741e-01 | 0.411 |
| R-HSA-373752 | Netrin-1 signaling | 3.883741e-01 | 0.411 |
| R-HSA-69236 | G1 Phase | 3.883741e-01 | 0.411 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.883741e-01 | 0.411 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.941389e-01 | 0.404 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.941389e-01 | 0.404 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.941389e-01 | 0.404 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.941389e-01 | 0.404 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.998498e-01 | 0.398 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.998498e-01 | 0.398 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.998498e-01 | 0.398 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.998498e-01 | 0.398 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.998498e-01 | 0.398 |
| R-HSA-9675135 | Diseases of DNA repair | 3.998498e-01 | 0.398 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.998498e-01 | 0.398 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.998498e-01 | 0.398 |
| R-HSA-5576891 | Cardiac conduction | 4.044826e-01 | 0.393 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.055071e-01 | 0.392 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.110410e-01 | 0.386 |
| R-HSA-425410 | Metal ion SLC transporters | 4.111115e-01 | 0.386 |
| R-HSA-162906 | HIV Infection | 4.129688e-01 | 0.384 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.166634e-01 | 0.380 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.166634e-01 | 0.380 |
| R-HSA-72766 | Translation | 4.201002e-01 | 0.377 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.272810e-01 | 0.369 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.305012e-01 | 0.366 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.383558e-01 | 0.358 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.436525e-01 | 0.353 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.464580e-01 | 0.350 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.488995e-01 | 0.348 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.496198e-01 | 0.347 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.540974e-01 | 0.343 |
| R-HSA-177929 | Signaling by EGFR | 4.540974e-01 | 0.343 |
| R-HSA-5578775 | Ion homeostasis | 4.540974e-01 | 0.343 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.540974e-01 | 0.343 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.567807e-01 | 0.340 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.592466e-01 | 0.338 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.624875e-01 | 0.335 |
| R-HSA-186712 | Regulation of beta-cell development | 4.694007e-01 | 0.328 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.694007e-01 | 0.328 |
| R-HSA-180786 | Extension of Telomeres | 4.694007e-01 | 0.328 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.694007e-01 | 0.328 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.714644e-01 | 0.327 |
| R-HSA-6798695 | Neutrophil degranulation | 4.716233e-01 | 0.326 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.744064e-01 | 0.324 |
| R-HSA-388396 | GPCR downstream signalling | 4.778379e-01 | 0.321 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.793653e-01 | 0.319 |
| R-HSA-112043 | PLC beta mediated events | 4.793653e-01 | 0.319 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.842777e-01 | 0.315 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.842777e-01 | 0.315 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.842777e-01 | 0.315 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.891440e-01 | 0.311 |
| R-HSA-373755 | Semaphorin interactions | 4.891440e-01 | 0.311 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.939647e-01 | 0.306 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.939647e-01 | 0.306 |
| R-HSA-9711097 | Cellular response to starvation | 4.957886e-01 | 0.305 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.987402e-01 | 0.302 |
| R-HSA-112040 | G-protein mediated events | 5.081573e-01 | 0.294 |
| R-HSA-196071 | Metabolism of steroid hormones | 5.081573e-01 | 0.294 |
| R-HSA-167172 | Transcription of the HIV genome | 5.127998e-01 | 0.290 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.135634e-01 | 0.289 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.219545e-01 | 0.282 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.219545e-01 | 0.282 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.219545e-01 | 0.282 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.219545e-01 | 0.282 |
| R-HSA-5619102 | SLC transporter disorders | 5.222963e-01 | 0.282 |
| R-HSA-3000178 | ECM proteoglycans | 5.264675e-01 | 0.279 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.309382e-01 | 0.275 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.309382e-01 | 0.275 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.309382e-01 | 0.275 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.353670e-01 | 0.271 |
| R-HSA-9749641 | Aspirin ADME | 5.353670e-01 | 0.271 |
| R-HSA-9658195 | Leishmania infection | 5.421816e-01 | 0.266 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.421816e-01 | 0.266 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.441003e-01 | 0.264 |
| R-HSA-5619084 | ABC transporter disorders | 5.568955e-01 | 0.254 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 5.568955e-01 | 0.254 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.599413e-01 | 0.252 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.734024e-01 | 0.242 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.751406e-01 | 0.240 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.853803e-01 | 0.233 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.853803e-01 | 0.233 |
| R-HSA-983712 | Ion channel transport | 5.857123e-01 | 0.232 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.892982e-01 | 0.230 |
| R-HSA-372790 | Signaling by GPCR | 5.912806e-01 | 0.228 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.931794e-01 | 0.227 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.935147e-01 | 0.227 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.157128e-01 | 0.211 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.229449e-01 | 0.206 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.265101e-01 | 0.203 |
| R-HSA-1474290 | Collagen formation | 6.265101e-01 | 0.203 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.300417e-01 | 0.201 |
| R-HSA-6805567 | Keratinization | 6.308888e-01 | 0.200 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.404390e-01 | 0.194 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.438398e-01 | 0.191 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.438398e-01 | 0.191 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.438398e-01 | 0.191 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.438398e-01 | 0.191 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.505458e-01 | 0.187 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.538517e-01 | 0.185 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.635840e-01 | 0.178 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.635840e-01 | 0.178 |
| R-HSA-111885 | Opioid Signalling | 6.635840e-01 | 0.178 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 6.667673e-01 | 0.176 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.699206e-01 | 0.174 |
| R-HSA-418346 | Platelet homeostasis | 6.730443e-01 | 0.172 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.761387e-01 | 0.170 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.761387e-01 | 0.170 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.792040e-01 | 0.168 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.792040e-01 | 0.168 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.792040e-01 | 0.168 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.822404e-01 | 0.166 |
| R-HSA-202403 | TCR signaling | 6.852483e-01 | 0.164 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.852483e-01 | 0.164 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.852483e-01 | 0.164 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.911795e-01 | 0.160 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.941033e-01 | 0.159 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.969996e-01 | 0.157 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.998687e-01 | 0.155 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.027107e-01 | 0.153 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.027107e-01 | 0.153 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.138142e-01 | 0.146 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.165250e-01 | 0.145 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.165250e-01 | 0.145 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.218705e-01 | 0.142 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.245055e-01 | 0.140 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.245055e-01 | 0.140 |
| R-HSA-449147 | Signaling by Interleukins | 7.333721e-01 | 0.135 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.373133e-01 | 0.132 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.479879e-01 | 0.126 |
| R-HSA-416476 | G alpha (q) signalling events | 7.505654e-01 | 0.125 |
| R-HSA-9909396 | Circadian clock | 7.542563e-01 | 0.122 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.576608e-01 | 0.121 |
| R-HSA-418594 | G alpha (i) signalling events | 7.716345e-01 | 0.113 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.744541e-01 | 0.111 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.744541e-01 | 0.111 |
| R-HSA-9664407 | Parasite infection | 7.744541e-01 | 0.111 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.765939e-01 | 0.110 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.808132e-01 | 0.107 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.930018e-01 | 0.101 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.988412e-01 | 0.098 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.007511e-01 | 0.097 |
| R-HSA-9609507 | Protein localization | 8.026429e-01 | 0.095 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.118378e-01 | 0.091 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.273289e-01 | 0.082 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.298429e-01 | 0.081 |
| R-HSA-72306 | tRNA processing | 8.338007e-01 | 0.079 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.353806e-01 | 0.078 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.384958e-01 | 0.076 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.384958e-01 | 0.076 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.400314e-01 | 0.076 |
| R-HSA-1474244 | Extracellular matrix organization | 8.460563e-01 | 0.073 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.573649e-01 | 0.067 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.581380e-01 | 0.066 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.640242e-01 | 0.063 |
| R-HSA-428157 | Sphingolipid metabolism | 8.764300e-01 | 0.057 |
| R-HSA-9748784 | Drug ADME | 8.959938e-01 | 0.048 |
| R-HSA-168249 | Innate Immune System | 8.981303e-01 | 0.047 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.051097e-01 | 0.043 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.133129e-01 | 0.039 |
| R-HSA-8978868 | Fatty acid metabolism | 9.141880e-01 | 0.039 |
| R-HSA-382551 | Transport of small molecules | 9.163270e-01 | 0.038 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.356297e-01 | 0.029 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.408727e-01 | 0.026 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.415302e-01 | 0.026 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.420899e-01 | 0.026 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.503534e-01 | 0.022 |
| R-HSA-8957322 | Metabolism of steroids | 9.624575e-01 | 0.017 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.789763e-01 | 0.009 |
| R-HSA-500792 | GPCR ligand binding | 9.802798e-01 | 0.009 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.845377e-01 | 0.007 |
| R-HSA-211859 | Biological oxidations | 9.946126e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.999407e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999554e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.819 | 0.327 | -3 | 0.909 |
COT |
0.813 | 0.144 | 2 | 0.864 |
MAPKAPK2 |
0.812 | 0.326 | -3 | 0.874 |
NDR2 |
0.810 | 0.220 | -3 | 0.869 |
RSK4 |
0.810 | 0.323 | -3 | 0.880 |
PIM3 |
0.808 | 0.247 | -3 | 0.881 |
CAMK1B |
0.807 | 0.301 | -3 | 0.914 |
PRKX |
0.807 | 0.327 | -3 | 0.870 |
P90RSK |
0.807 | 0.274 | -3 | 0.897 |
CLK3 |
0.807 | 0.216 | 1 | 0.821 |
P70S6KB |
0.807 | 0.304 | -3 | 0.919 |
PRKD2 |
0.807 | 0.284 | -3 | 0.912 |
PRKD1 |
0.806 | 0.222 | -3 | 0.886 |
RSK3 |
0.806 | 0.264 | -3 | 0.896 |
PKACG |
0.805 | 0.263 | -2 | 0.712 |
PIM1 |
0.805 | 0.298 | -3 | 0.895 |
PKN3 |
0.805 | 0.227 | -3 | 0.889 |
CAMK2B |
0.805 | 0.263 | 2 | 0.747 |
SKMLCK |
0.801 | 0.220 | -2 | 0.743 |
PKACB |
0.801 | 0.252 | -2 | 0.644 |
MSK1 |
0.801 | 0.242 | -3 | 0.877 |
LATS2 |
0.801 | 0.170 | -5 | 0.732 |
CAMK2G |
0.799 | 0.113 | 2 | 0.783 |
CAMK2A |
0.799 | 0.240 | 2 | 0.761 |
PKN2 |
0.799 | 0.201 | -3 | 0.901 |
MSK2 |
0.798 | 0.219 | -3 | 0.864 |
NDR1 |
0.798 | 0.196 | -3 | 0.896 |
GRK1 |
0.797 | 0.143 | -2 | 0.615 |
MAPKAPK3 |
0.797 | 0.225 | -3 | 0.898 |
CDKL1 |
0.797 | 0.209 | -3 | 0.888 |
NUAK2 |
0.796 | 0.182 | -3 | 0.925 |
AMPKA1 |
0.796 | 0.179 | -3 | 0.912 |
SGK3 |
0.796 | 0.290 | -3 | 0.900 |
CLK2 |
0.795 | 0.265 | -3 | 0.893 |
RAF1 |
0.795 | 0.041 | 1 | 0.868 |
DSTYK |
0.795 | 0.046 | 2 | 0.857 |
CDC7 |
0.794 | -0.012 | 1 | 0.845 |
IKKB |
0.794 | 0.010 | -2 | 0.612 |
TSSK2 |
0.794 | 0.175 | -5 | 0.788 |
TSSK1 |
0.793 | 0.188 | -3 | 0.916 |
CAMK2D |
0.793 | 0.148 | -3 | 0.894 |
PRPK |
0.792 | -0.033 | -1 | 0.733 |
GRK6 |
0.792 | 0.154 | 1 | 0.938 |
AMPKA2 |
0.792 | 0.183 | -3 | 0.917 |
PAK1 |
0.792 | 0.140 | -2 | 0.663 |
MOS |
0.791 | 0.043 | 1 | 0.860 |
PKACA |
0.791 | 0.252 | -2 | 0.614 |
DAPK2 |
0.791 | 0.196 | -3 | 0.900 |
LATS1 |
0.791 | 0.224 | -3 | 0.856 |
PRKD3 |
0.791 | 0.251 | -3 | 0.909 |
MYLK4 |
0.791 | 0.190 | -2 | 0.662 |
CAMLCK |
0.791 | 0.164 | -2 | 0.729 |
SRPK1 |
0.791 | 0.188 | -3 | 0.875 |
PKCD |
0.791 | 0.148 | 2 | 0.769 |
WNK1 |
0.790 | 0.101 | -2 | 0.769 |
HUNK |
0.789 | 0.012 | 2 | 0.809 |
MST4 |
0.789 | 0.088 | 2 | 0.793 |
CAMK4 |
0.789 | 0.190 | -3 | 0.910 |
SRPK2 |
0.788 | 0.201 | -3 | 0.846 |
PKG2 |
0.788 | 0.211 | -2 | 0.677 |
CDKL5 |
0.788 | 0.155 | -3 | 0.895 |
TBK1 |
0.788 | -0.053 | 1 | 0.787 |
MTOR |
0.788 | -0.064 | 1 | 0.818 |
ULK2 |
0.788 | -0.102 | 2 | 0.761 |
AKT2 |
0.788 | 0.257 | -3 | 0.887 |
TGFBR1 |
0.787 | 0.136 | -2 | 0.676 |
NUAK1 |
0.787 | 0.160 | -3 | 0.918 |
MNK1 |
0.787 | 0.164 | -2 | 0.737 |
PLK1 |
0.787 | 0.099 | -2 | 0.721 |
FAM20C |
0.786 | 0.074 | 2 | 0.606 |
MARK4 |
0.786 | 0.022 | 4 | 0.619 |
NIK |
0.786 | 0.125 | -3 | 0.879 |
AURC |
0.786 | 0.104 | -2 | 0.599 |
IKKA |
0.786 | 0.017 | -2 | 0.612 |
CAMK1G |
0.785 | 0.212 | -3 | 0.910 |
GRK7 |
0.784 | 0.173 | 1 | 0.920 |
SIK |
0.784 | 0.152 | -3 | 0.903 |
ICK |
0.784 | 0.140 | -3 | 0.893 |
IKKE |
0.784 | -0.061 | 1 | 0.781 |
P70S6K |
0.783 | 0.264 | -3 | 0.889 |
SGK1 |
0.783 | 0.311 | -3 | 0.828 |
MELK |
0.783 | 0.171 | -3 | 0.924 |
CLK4 |
0.783 | 0.182 | -3 | 0.914 |
PAK3 |
0.783 | 0.080 | -2 | 0.663 |
GCN2 |
0.782 | -0.149 | 2 | 0.747 |
CLK1 |
0.782 | 0.193 | -3 | 0.919 |
PDHK4 |
0.782 | -0.213 | 1 | 0.878 |
ALK4 |
0.782 | 0.094 | -2 | 0.697 |
MNK2 |
0.782 | 0.106 | -2 | 0.717 |
BRSK1 |
0.782 | 0.139 | -3 | 0.907 |
ATR |
0.782 | -0.025 | 1 | 0.811 |
NLK |
0.782 | -0.034 | 1 | 0.815 |
CAMK1D |
0.781 | 0.265 | -3 | 0.887 |
PIM2 |
0.781 | 0.244 | -3 | 0.912 |
ULK1 |
0.781 | -0.093 | -3 | 0.716 |
PKCG |
0.781 | 0.101 | 2 | 0.738 |
HIPK4 |
0.780 | 0.075 | 1 | 0.732 |
RIPK3 |
0.780 | -0.067 | 3 | 0.700 |
BMPR2 |
0.780 | -0.179 | -2 | 0.763 |
AURB |
0.780 | 0.088 | -2 | 0.582 |
ATM |
0.780 | 0.034 | 1 | 0.752 |
DCAMKL1 |
0.779 | 0.231 | -3 | 0.914 |
NEK7 |
0.779 | -0.106 | -3 | 0.735 |
DRAK1 |
0.779 | 0.129 | 1 | 0.821 |
AURA |
0.779 | 0.079 | -2 | 0.518 |
WNK3 |
0.779 | -0.059 | 1 | 0.825 |
DCAMKL2 |
0.778 | 0.207 | -3 | 0.933 |
PKCB |
0.778 | 0.110 | 2 | 0.721 |
NIM1 |
0.778 | 0.024 | 3 | 0.701 |
PASK |
0.778 | 0.254 | -3 | 0.860 |
GRK5 |
0.778 | -0.068 | -3 | 0.744 |
PAK2 |
0.777 | 0.066 | -2 | 0.632 |
QSK |
0.777 | 0.082 | 4 | 0.588 |
MAPKAPK5 |
0.777 | 0.155 | -3 | 0.858 |
PAK6 |
0.777 | 0.075 | -2 | 0.562 |
MARK3 |
0.777 | 0.058 | 4 | 0.557 |
PKCH |
0.776 | 0.098 | 2 | 0.713 |
SRPK3 |
0.776 | 0.143 | -3 | 0.846 |
NEK6 |
0.775 | -0.087 | -2 | 0.757 |
PDHK1 |
0.775 | -0.208 | 1 | 0.863 |
CHAK2 |
0.775 | -0.048 | -1 | 0.756 |
PLK3 |
0.775 | 0.049 | 2 | 0.783 |
DLK |
0.775 | -0.012 | 1 | 0.883 |
TTBK2 |
0.774 | -0.076 | 2 | 0.708 |
SMMLCK |
0.774 | 0.199 | -3 | 0.909 |
MASTL |
0.774 | -0.129 | -2 | 0.687 |
ERK5 |
0.774 | -0.065 | 1 | 0.737 |
TGFBR2 |
0.774 | -0.082 | -2 | 0.667 |
MARK2 |
0.774 | 0.034 | 4 | 0.536 |
CHK1 |
0.774 | 0.112 | -3 | 0.877 |
AKT1 |
0.774 | 0.206 | -3 | 0.897 |
BCKDK |
0.773 | -0.109 | -1 | 0.660 |
RIPK1 |
0.773 | -0.051 | 1 | 0.817 |
SSTK |
0.772 | 0.128 | 4 | 0.571 |
BMPR1B |
0.771 | 0.063 | 1 | 0.823 |
PKCA |
0.771 | 0.061 | 2 | 0.715 |
DYRK2 |
0.771 | 0.072 | 1 | 0.658 |
DAPK1 |
0.771 | 0.217 | -3 | 0.904 |
QIK |
0.771 | 0.015 | -3 | 0.899 |
MARK1 |
0.771 | 0.046 | 4 | 0.580 |
DAPK3 |
0.771 | 0.213 | -3 | 0.911 |
GRK4 |
0.771 | -0.076 | -2 | 0.679 |
ALK2 |
0.770 | 0.080 | -2 | 0.668 |
BRSK2 |
0.769 | 0.045 | -3 | 0.914 |
MLK1 |
0.769 | -0.153 | 2 | 0.789 |
MRCKA |
0.769 | 0.244 | -3 | 0.906 |
ANKRD3 |
0.769 | -0.104 | 1 | 0.856 |
ACVR2B |
0.768 | 0.039 | -2 | 0.678 |
SNRK |
0.768 | 0.018 | 2 | 0.712 |
AKT3 |
0.768 | 0.231 | -3 | 0.837 |
ACVR2A |
0.767 | 0.019 | -2 | 0.664 |
DYRK4 |
0.767 | 0.105 | 1 | 0.577 |
NEK9 |
0.767 | -0.155 | 2 | 0.787 |
DNAPK |
0.766 | 0.028 | 1 | 0.690 |
DYRK1A |
0.766 | 0.122 | 1 | 0.698 |
PHKG1 |
0.765 | 0.040 | -3 | 0.901 |
PLK4 |
0.765 | -0.039 | 2 | 0.651 |
PHKG2 |
0.764 | 0.103 | -3 | 0.933 |
CAMK1A |
0.764 | 0.224 | -3 | 0.863 |
PKCZ |
0.764 | 0.013 | 2 | 0.755 |
BRAF |
0.764 | 0.021 | -4 | 0.744 |
PKR |
0.764 | -0.020 | 1 | 0.829 |
MRCKB |
0.764 | 0.229 | -3 | 0.910 |
MEK1 |
0.763 | -0.087 | 2 | 0.810 |
HIPK1 |
0.762 | 0.095 | 1 | 0.670 |
PKCT |
0.762 | 0.079 | 2 | 0.715 |
CK2A2 |
0.762 | 0.146 | 1 | 0.720 |
GRK2 |
0.762 | -0.014 | -2 | 0.584 |
NEK2 |
0.761 | -0.063 | 2 | 0.768 |
JNK2 |
0.761 | 0.023 | 1 | 0.584 |
PKN1 |
0.761 | 0.165 | -3 | 0.909 |
BMPR1A |
0.761 | 0.061 | 1 | 0.808 |
DYRK1B |
0.761 | 0.077 | 1 | 0.625 |
KIS |
0.760 | -0.055 | 1 | 0.643 |
HIPK2 |
0.760 | 0.077 | 1 | 0.554 |
CDK8 |
0.760 | -0.067 | 1 | 0.617 |
IRE2 |
0.759 | -0.077 | 2 | 0.731 |
JNK3 |
0.759 | 0.004 | 1 | 0.624 |
CHK2 |
0.759 | 0.218 | -3 | 0.866 |
ROCK2 |
0.759 | 0.238 | -3 | 0.907 |
PAK4 |
0.759 | 0.043 | -2 | 0.498 |
SBK |
0.758 | 0.246 | -3 | 0.822 |
VRK2 |
0.758 | -0.186 | 1 | 0.870 |
CDK7 |
0.758 | -0.048 | 1 | 0.618 |
PAK5 |
0.758 | 0.043 | -2 | 0.497 |
MLK3 |
0.757 | -0.111 | 2 | 0.727 |
YSK4 |
0.757 | -0.116 | 1 | 0.805 |
DYRK3 |
0.757 | 0.110 | 1 | 0.672 |
WNK4 |
0.757 | -0.011 | -2 | 0.749 |
IRE1 |
0.757 | -0.146 | 1 | 0.761 |
MLK2 |
0.757 | -0.203 | 2 | 0.775 |
PKCE |
0.757 | 0.119 | 2 | 0.717 |
CRIK |
0.757 | 0.288 | -3 | 0.883 |
TLK2 |
0.756 | -0.107 | 1 | 0.800 |
DMPK1 |
0.755 | 0.248 | -3 | 0.918 |
PKG1 |
0.755 | 0.189 | -2 | 0.633 |
CHAK1 |
0.754 | -0.133 | 2 | 0.736 |
CDK19 |
0.753 | -0.067 | 1 | 0.574 |
MEKK3 |
0.752 | -0.100 | 1 | 0.838 |
MST3 |
0.752 | -0.006 | 2 | 0.807 |
CK2A1 |
0.752 | 0.117 | 1 | 0.708 |
HIPK3 |
0.751 | 0.054 | 1 | 0.673 |
CDK1 |
0.751 | -0.036 | 1 | 0.613 |
CDK2 |
0.751 | -0.052 | 1 | 0.750 |
PKCI |
0.751 | 0.029 | 2 | 0.723 |
P38A |
0.750 | -0.039 | 1 | 0.642 |
PLK2 |
0.750 | 0.029 | -3 | 0.612 |
CK1E |
0.750 | -0.063 | -3 | 0.417 |
TAO3 |
0.750 | -0.019 | 1 | 0.828 |
MLK4 |
0.750 | -0.147 | 2 | 0.703 |
GSK3A |
0.750 | -0.030 | 4 | 0.333 |
GSK3B |
0.750 | -0.051 | 4 | 0.314 |
GRK3 |
0.750 | -0.017 | -2 | 0.534 |
IRAK4 |
0.749 | -0.083 | 1 | 0.773 |
ROCK1 |
0.749 | 0.217 | -3 | 0.909 |
CDK18 |
0.748 | -0.050 | 1 | 0.559 |
SMG1 |
0.748 | -0.121 | 1 | 0.748 |
TTBK1 |
0.747 | -0.108 | 2 | 0.653 |
CDK9 |
0.747 | -0.053 | 1 | 0.609 |
CDK14 |
0.747 | -0.015 | 1 | 0.617 |
CDK13 |
0.747 | -0.074 | 1 | 0.600 |
CDK17 |
0.747 | -0.044 | 1 | 0.530 |
ZAK |
0.747 | -0.155 | 1 | 0.816 |
P38G |
0.747 | -0.025 | 1 | 0.517 |
TLK1 |
0.747 | -0.108 | -2 | 0.718 |
PRP4 |
0.746 | -0.055 | -3 | 0.643 |
MEKK1 |
0.745 | -0.172 | 1 | 0.824 |
P38B |
0.745 | -0.035 | 1 | 0.593 |
NEK5 |
0.745 | -0.137 | 1 | 0.812 |
PDK1 |
0.745 | 0.028 | 1 | 0.802 |
ERK2 |
0.745 | -0.072 | 1 | 0.636 |
CDK5 |
0.744 | -0.063 | 1 | 0.639 |
GAK |
0.744 | 0.014 | 1 | 0.793 |
MEK5 |
0.744 | -0.228 | 2 | 0.793 |
CDK10 |
0.743 | 0.021 | 1 | 0.591 |
CDK12 |
0.743 | -0.057 | 1 | 0.579 |
JNK1 |
0.743 | 0.002 | 1 | 0.598 |
CK1A2 |
0.743 | -0.049 | -3 | 0.382 |
HRI |
0.742 | -0.209 | -2 | 0.725 |
YANK3 |
0.742 | 0.053 | 2 | 0.466 |
IRAK1 |
0.742 | -0.176 | -1 | 0.633 |
TAO2 |
0.741 | -0.062 | 2 | 0.814 |
PERK |
0.741 | -0.201 | -2 | 0.684 |
NEK11 |
0.741 | -0.129 | 1 | 0.822 |
ERK1 |
0.741 | -0.064 | 1 | 0.566 |
MEKK2 |
0.741 | -0.173 | 2 | 0.766 |
CAMKK1 |
0.739 | -0.134 | -2 | 0.611 |
CK1D |
0.739 | -0.069 | -3 | 0.369 |
CDK3 |
0.739 | -0.026 | 1 | 0.538 |
MAK |
0.739 | 0.116 | -2 | 0.626 |
CDK16 |
0.739 | -0.039 | 1 | 0.548 |
STK33 |
0.739 | -0.056 | 2 | 0.660 |
NEK8 |
0.738 | -0.137 | 2 | 0.798 |
GCK |
0.738 | -0.025 | 1 | 0.834 |
CK1G1 |
0.737 | -0.106 | -3 | 0.391 |
CAMKK2 |
0.736 | -0.132 | -2 | 0.605 |
PINK1 |
0.735 | -0.220 | 1 | 0.755 |
EEF2K |
0.734 | -0.082 | 3 | 0.700 |
MOK |
0.733 | 0.105 | 1 | 0.656 |
LOK |
0.733 | -0.014 | -2 | 0.693 |
NEK4 |
0.733 | -0.141 | 1 | 0.798 |
MAP3K15 |
0.733 | -0.116 | 1 | 0.789 |
VRK1 |
0.732 | -0.093 | 2 | 0.821 |
MST2 |
0.732 | -0.132 | 1 | 0.847 |
SLK |
0.732 | -0.021 | -2 | 0.625 |
HPK1 |
0.732 | -0.025 | 1 | 0.823 |
LKB1 |
0.732 | -0.136 | -3 | 0.761 |
P38D |
0.731 | -0.040 | 1 | 0.484 |
TAK1 |
0.731 | -0.088 | 1 | 0.817 |
LRRK2 |
0.731 | -0.107 | 2 | 0.817 |
BUB1 |
0.731 | 0.042 | -5 | 0.736 |
MST1 |
0.730 | -0.094 | 1 | 0.833 |
TNIK |
0.728 | -0.079 | 3 | 0.701 |
PDHK3_TYR |
0.728 | 0.211 | 4 | 0.719 |
MPSK1 |
0.728 | -0.134 | 1 | 0.693 |
RIPK2 |
0.728 | -0.155 | 1 | 0.767 |
MEKK6 |
0.728 | -0.148 | 1 | 0.790 |
NEK1 |
0.728 | -0.138 | 1 | 0.804 |
KHS1 |
0.728 | -0.028 | 1 | 0.807 |
MINK |
0.726 | -0.134 | 1 | 0.807 |
KHS2 |
0.726 | -0.010 | 1 | 0.819 |
ALPHAK3 |
0.726 | 0.022 | -1 | 0.684 |
CDK4 |
0.724 | -0.042 | 1 | 0.571 |
ERK7 |
0.724 | -0.053 | 2 | 0.528 |
HASPIN |
0.723 | 0.010 | -1 | 0.620 |
PBK |
0.723 | -0.029 | 1 | 0.682 |
HGK |
0.722 | -0.160 | 3 | 0.714 |
MEK2 |
0.722 | -0.212 | 2 | 0.764 |
YSK1 |
0.722 | -0.105 | 2 | 0.758 |
EPHA6 |
0.719 | 0.127 | -1 | 0.754 |
BMPR2_TYR |
0.719 | 0.095 | -1 | 0.778 |
MAP2K6_TYR |
0.718 | 0.087 | -1 | 0.778 |
CDK6 |
0.718 | -0.079 | 1 | 0.573 |
PDHK4_TYR |
0.717 | 0.065 | 2 | 0.851 |
PDHK1_TYR |
0.717 | 0.086 | -1 | 0.798 |
TESK1_TYR |
0.716 | -0.001 | 3 | 0.782 |
PINK1_TYR |
0.716 | 0.062 | 1 | 0.861 |
MAP2K4_TYR |
0.715 | 0.004 | -1 | 0.757 |
DDR1 |
0.715 | 0.067 | 4 | 0.661 |
MAP2K7_TYR |
0.715 | -0.032 | 2 | 0.832 |
EPHA4 |
0.715 | 0.117 | 2 | 0.799 |
EPHB4 |
0.714 | 0.071 | -1 | 0.722 |
TTK |
0.714 | -0.104 | -2 | 0.707 |
DDR2 |
0.714 | 0.169 | 3 | 0.747 |
INSRR |
0.713 | 0.081 | 3 | 0.728 |
PKMYT1_TYR |
0.712 | -0.079 | 3 | 0.780 |
OSR1 |
0.711 | -0.122 | 2 | 0.757 |
RET |
0.711 | 0.021 | 1 | 0.845 |
NEK3 |
0.711 | -0.198 | 1 | 0.751 |
FGFR2 |
0.710 | 0.088 | 3 | 0.767 |
ASK1 |
0.710 | -0.137 | 1 | 0.784 |
LIMK2_TYR |
0.710 | 0.003 | -3 | 0.851 |
EPHB1 |
0.709 | 0.065 | 1 | 0.899 |
SRMS |
0.709 | 0.071 | 1 | 0.915 |
MST1R |
0.709 | -0.020 | 3 | 0.759 |
EPHB2 |
0.708 | 0.078 | -1 | 0.702 |
EPHB3 |
0.708 | 0.063 | -1 | 0.705 |
TAO1 |
0.707 | -0.098 | 1 | 0.752 |
EPHA7 |
0.706 | 0.080 | 2 | 0.803 |
CK1A |
0.706 | -0.083 | -3 | 0.272 |
ROS1 |
0.705 | -0.055 | 3 | 0.718 |
YANK2 |
0.705 | 0.005 | 2 | 0.479 |
BIKE |
0.705 | -0.060 | 1 | 0.639 |
TNK2 |
0.705 | 0.008 | 3 | 0.759 |
TYK2 |
0.704 | -0.089 | 1 | 0.836 |
FGFR1 |
0.704 | 0.025 | 3 | 0.761 |
TEK |
0.703 | 0.014 | 3 | 0.712 |
FER |
0.703 | -0.009 | 1 | 0.908 |
TYRO3 |
0.703 | -0.100 | 3 | 0.737 |
MYO3A |
0.703 | -0.139 | 1 | 0.807 |
CSF1R |
0.702 | -0.057 | 3 | 0.736 |
AXL |
0.702 | 0.001 | 3 | 0.749 |
YES1 |
0.702 | -0.028 | -1 | 0.695 |
EPHA5 |
0.701 | 0.102 | 2 | 0.791 |
EGFR |
0.701 | 0.143 | 1 | 0.880 |
FGFR3 |
0.701 | 0.065 | 3 | 0.750 |
JAK3 |
0.701 | -0.025 | 1 | 0.816 |
EPHA8 |
0.701 | 0.111 | -1 | 0.718 |
EPHA3 |
0.700 | 0.030 | 2 | 0.774 |
KDR |
0.700 | 0.005 | 3 | 0.717 |
JAK2 |
0.700 | -0.097 | 1 | 0.824 |
LIMK1_TYR |
0.700 | -0.157 | 2 | 0.815 |
MYO3B |
0.700 | -0.156 | 2 | 0.774 |
KIT |
0.699 | -0.017 | 3 | 0.747 |
TXK |
0.699 | -0.000 | 1 | 0.864 |
PDGFRB |
0.699 | -0.052 | 3 | 0.753 |
NTRK1 |
0.699 | 0.006 | -1 | 0.669 |
FLT3 |
0.698 | -0.028 | 3 | 0.727 |
ERBB2 |
0.698 | 0.043 | 1 | 0.913 |
ITK |
0.698 | -0.025 | -1 | 0.653 |
MERTK |
0.698 | -0.014 | 3 | 0.739 |
MET |
0.697 | -0.002 | 3 | 0.747 |
ABL2 |
0.697 | -0.056 | -1 | 0.659 |
ALK |
0.697 | -0.014 | 3 | 0.731 |
PTK2 |
0.697 | 0.111 | -1 | 0.712 |
LTK |
0.696 | -0.012 | 3 | 0.744 |
FGR |
0.695 | -0.076 | 1 | 0.869 |
TNK1 |
0.695 | -0.044 | 3 | 0.710 |
FLT4 |
0.695 | 0.000 | 3 | 0.723 |
BMX |
0.695 | -0.014 | -1 | 0.578 |
FYN |
0.695 | 0.042 | -1 | 0.683 |
EPHA2 |
0.695 | 0.110 | -1 | 0.676 |
ERBB4 |
0.695 | 0.156 | 1 | 0.914 |
EPHA1 |
0.695 | -0.013 | 3 | 0.729 |
FRK |
0.695 | 0.036 | -1 | 0.716 |
STLK3 |
0.694 | -0.185 | 1 | 0.797 |
INSR |
0.693 | -0.047 | 3 | 0.696 |
FLT1 |
0.693 | 0.013 | -1 | 0.748 |
SYK |
0.693 | 0.120 | -1 | 0.715 |
PTK2B |
0.693 | 0.014 | -1 | 0.593 |
FGFR4 |
0.693 | 0.049 | -1 | 0.653 |
HCK |
0.692 | -0.093 | -1 | 0.688 |
BLK |
0.692 | -0.024 | -1 | 0.721 |
CSK |
0.691 | 0.019 | 2 | 0.799 |
PDGFRA |
0.690 | -0.113 | 3 | 0.748 |
MATK |
0.690 | -0.006 | -1 | 0.619 |
ABL1 |
0.689 | -0.110 | -1 | 0.639 |
NTRK3 |
0.688 | -0.034 | -1 | 0.630 |
TEC |
0.688 | -0.086 | -1 | 0.565 |
JAK1 |
0.688 | -0.083 | 1 | 0.782 |
IGF1R |
0.687 | 0.011 | 3 | 0.658 |
LCK |
0.687 | -0.077 | -1 | 0.697 |
AAK1 |
0.687 | -0.038 | 1 | 0.512 |
CK1G2 |
0.687 | -0.027 | -3 | 0.314 |
NTRK2 |
0.686 | -0.104 | 3 | 0.746 |
NEK10_TYR |
0.686 | -0.101 | 1 | 0.673 |
CK1G3 |
0.685 | -0.087 | -3 | 0.227 |
TNNI3K_TYR |
0.682 | -0.127 | 1 | 0.804 |
SRC |
0.682 | -0.029 | -1 | 0.664 |
BTK |
0.681 | -0.185 | -1 | 0.595 |
WEE1_TYR |
0.680 | -0.129 | -1 | 0.611 |
MUSK |
0.679 | 0.043 | 1 | 0.857 |
PTK6 |
0.678 | -0.191 | -1 | 0.561 |
LYN |
0.678 | -0.108 | 3 | 0.686 |
ZAP70 |
0.669 | 0.070 | -1 | 0.621 |
FES |
0.669 | -0.042 | -1 | 0.541 |