Motif 785 (n=108)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | S112 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A1X283 | SH3PXD2B | S811 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| A6NHL2 | TUBAL3 | Y326 | ochoa | Tubulin alpha chain-like 3 (EC 3.6.5.-) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| O14936 | CASK | S151 | psp | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O15541 | RNF113A | S169 | ochoa | E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). {ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| O43318 | MAP3K7 | S417 | ochoa | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O43707 | ACTN4 | S121 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43707 | ACTN4 | S263 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60938 | KERA | S256 | ochoa | Keratocan (KTN) (Keratan sulfate proteoglycan keratocan) | May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. {ECO:0000305|PubMed:10802664, ECO:0000305|PubMed:11726611}. |
| O75369 | FLNB | S2532 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75417 | POLQ | S2267 | ochoa | DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] | Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). {ECO:0000250|UniProtKB:Q8CGS6, ECO:0000269|PubMed:14576298, ECO:0000269|PubMed:18503084, ECO:0000269|PubMed:19188258, ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:22135286, ECO:0000269|PubMed:24648516, ECO:0000269|PubMed:25642963, ECO:0000269|PubMed:25643323, ECO:0000269|PubMed:25775267, ECO:0000269|PubMed:26636256, ECO:0000269|PubMed:27311885, ECO:0000269|PubMed:27591252, ECO:0000269|PubMed:28695890, ECO:0000269|PubMed:30655289, ECO:0000269|PubMed:31562312, ECO:0000269|PubMed:32234782, ECO:0000269|PubMed:32873648, ECO:0000269|PubMed:34117057, ECO:0000269|PubMed:34140467, ECO:0000269|PubMed:34179826, ECO:0000269|PubMed:36455556, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080}. |
| O75764 | TCEA3 | S81 | ochoa | Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| O94906 | PRPF6 | S279 | ochoa | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}. |
| O95251 | KAT7 | S192 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95622 | ADCY5 | S666 | ochoa | Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:24700542, PubMed:26206488). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}. |
| O96028 | NSD2 | S30 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P05387 | RPLP2 | S29 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P08047 | SP1 | S720 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08240 | SRPRA | S177 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P0DMV8 | HSPA1A | S85 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S85 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P10243 | MYBL1 | S458 | ochoa | Myb-related protein A (A-Myb) (Myb-like protein 1) | Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7987850, PubMed:8058310). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). {ECO:0000250|UniProtKB:P51960, ECO:0000269|PubMed:7987850, ECO:0000269|PubMed:8058310}. |
| P10412 | H1-4 | S89 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10645 | CHGA | S207 | ochoa | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P11908 | PRPS2 | S238 | ochoa | Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
| P12109 | COL6A1 | S746 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P12814 | ACTN1 | S102 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12814 | ACTN1 | S244 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P16401 | H1-5 | S92 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S90 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S89 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P21333 | FLNA | S2577 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23284 | PPIB | S189 | ochoa | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}. |
| P25054 | APC | S2262 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25490 | YY1 | S187 | ochoa | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P29017 | CD1C | S215 | ochoa | T-cell surface glycoprotein CD1c (CD antigen CD1c) | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10786796, ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:21167756}. |
| P35609 | ACTN2 | S109 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P37059 | HSD17B2 | S219 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
| P40818 | USP8 | S584 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P46940 | IQGAP1 | S1540 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P48047 | ATP5PO | S166 | ochoa | ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP synthase subunit O) (Oligomycin sensitivity conferral protein) (OSCP) | Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13621, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P51948 | MNAT1 | S224 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P52701 | MSH6 | S668 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P54132 | BLM | S602 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P60891 | PRPS1 | S238 | ochoa | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P61073 | CXCR4 | Y157 | psp | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250|UniProtKB:P70658, ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10452968, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:18799424, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:24912431, ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609). {ECO:0000269|PubMed:10074122, ECO:0000269|PubMed:10756055, ECO:0000269|PubMed:8849450, ECO:0000269|PubMed:8929542, ECO:0000269|PubMed:9427609}. |
| P68363 | TUBA1B | Y319 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | Y319 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78371 | CCT2 | S54 | psp | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q00403 | GTF2B | S76 | ochoa | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| Q00722 | PLCB2 | S964 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:1644792, PubMed:9188725). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:A3KGF7, ECO:0000269|PubMed:1644792, ECO:0000269|PubMed:9188725}. |
| Q02539 | H1-1 | S92 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q02641 | CACNB1 | S193 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q08043 | ACTN3 | S116 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q09666 | AHNAK | S856 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12965 | MYO1E | S890 | ochoa | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}. |
| Q13043 | STK4 | S410 | ochoa|psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13201 | MMRN1 | S522 | ochoa | Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}. |
| Q13428 | TCOF1 | S1410 | ochoa|psp | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14141 | SEPTIN6 | S408 | ochoa | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| Q14247 | CTTN | S155 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14699 | RFTN1 | S171 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q15365 | PCBP1 | S322 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q16851 | UGP2 | S120 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Q5VTT5 | MYOM3 | S241 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q6GQQ9 | OTUD7B | S508 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6UN15 | FIP1L1 | S112 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q71U36 | TUBA1A | Y319 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q76FK4 | NOL8 | S508 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q86XJ1 | GAS2L3 | S607 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q8IUD2 | ERC1 | S687 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IVF2 | AHNAK2 | S842 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1172 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1997 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2327 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2657 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4472 | ochoa | Protein AHNAK2 | None |
| Q8IW00 | VSTM4 | S223 | ochoa | V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv] | Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors. {ECO:0000250|UniProtKB:T1NXB5}. |
| Q8IW41 | MAPKAPK5 | S354 | ochoa|psp | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8N392 | ARHGAP18 | S263 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8N556 | AFAP1 | S283 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8TCU6 | PREX1 | S1049 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8WUH6 | TMEM263 | S77 | ochoa | Transmembrane protein 263 | May play a role in bone development. {ECO:0000269|PubMed:34238371}. |
| Q8WXG6 | MADD | S745 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q8WYH8 | ING5 | S122 | ochoa | Inhibitor of growth protein 5 (p28ING5) | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21750715, ECO:0000269|PubMed:24065767}. |
| Q96AE4 | FUBP1 | S84 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96CP2 | FLYWCH2 | S67 | ochoa | FLYWCH family member 2 | None |
| Q96K49 | TMEM87B | S496 | ochoa | Transmembrane protein 87B | May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. |
| Q96M89 | CCDC138 | S49 | ochoa | Coiled-coil domain-containing protein 138 | None |
| Q96N67 | DOCK7 | S1403 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96PV7 | FAM193B | S709 | ochoa | Protein FAM193B | None |
| Q9BQE3 | TUBA1C | Y319 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H5I5 | PIEZO2 | S1841 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H6A0 | DENND2D | S357 | ochoa | DENN domain-containing protein 2D | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q9H8T0 | AKTIP | S237 | psp | AKT-interacting protein (Ft1) (Fused toes protein homolog) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9HCK1 | ZDBF2 | S631 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NP62 | GCM1 | S275 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NQ75 | CASS4 | S311 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NYL9 | TMOD3 | S156 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9UIF8 | BAZ2B | S1269 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UKI8 | TLK1 | S134 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9Y2X9 | ZNF281 | S800 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| P34932 | HSPA4 | S40 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P40763 | STAT3 | S181 | Sugiyama | Signal transducer and activator of transcription 3 (Acute-phase response factor) | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:38404237}. |
| P13639 | EEF2 | S793 | Sugiyama | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| Q07157 | TJP1 | S585 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| O75436 | VPS26A | Y43 | Sugiyama | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}. |
| Q96RE7 | NACC1 | S175 | Sugiyama | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 3.330669e-15 | 14.477 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.740652e-14 | 13.324 |
| R-HSA-3371511 | HSF1 activation | 1.781353e-12 | 11.749 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.852563e-12 | 11.314 |
| R-HSA-3371556 | Cellular response to heat stress | 4.271772e-11 | 10.369 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.546741e-11 | 10.020 |
| R-HSA-2262752 | Cellular responses to stress | 1.276380e-10 | 9.894 |
| R-HSA-373753 | Nephrin family interactions | 4.618564e-08 | 7.335 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 6.305467e-08 | 7.200 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.126306e-07 | 6.948 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.337611e-07 | 6.874 |
| R-HSA-75153 | Apoptotic execution phase | 2.155863e-07 | 6.666 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.354158e-07 | 6.628 |
| R-HSA-9833482 | PKR-mediated signaling | 4.136199e-07 | 6.383 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.510774e-07 | 6.346 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 8.292771e-07 | 6.081 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.322252e-07 | 6.080 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.029498e-06 | 5.987 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.543432e-06 | 5.812 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.058530e-06 | 5.686 |
| R-HSA-157858 | Gap junction trafficking and regulation | 5.337211e-06 | 5.273 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 6.804601e-06 | 5.167 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 9.336457e-06 | 5.030 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.311457e-05 | 4.882 |
| R-HSA-391251 | Protein folding | 1.375380e-05 | 4.862 |
| R-HSA-190861 | Gap junction assembly | 1.664033e-05 | 4.779 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.691480e-05 | 4.772 |
| R-HSA-2559583 | Cellular Senescence | 2.188376e-05 | 4.660 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.632317e-05 | 4.580 |
| R-HSA-9646399 | Aggrephagy | 3.178153e-05 | 4.498 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.308702e-05 | 4.480 |
| R-HSA-190828 | Gap junction trafficking | 5.113840e-05 | 4.291 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.649286e-05 | 4.177 |
| R-HSA-437239 | Recycling pathway of L1 | 6.649286e-05 | 4.177 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.086329e-05 | 4.150 |
| R-HSA-109581 | Apoptosis | 7.155978e-05 | 4.145 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 7.553500e-05 | 4.122 |
| R-HSA-438064 | Post NMDA receptor activation events | 9.608378e-05 | 4.017 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.250151e-04 | 3.903 |
| R-HSA-983189 | Kinesins | 1.777776e-04 | 3.750 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.030740e-04 | 3.692 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.837706e-04 | 3.547 |
| R-HSA-5357801 | Programmed Cell Death | 3.227404e-04 | 3.491 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.946284e-04 | 3.404 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.729625e-04 | 3.242 |
| R-HSA-114608 | Platelet degranulation | 7.615385e-04 | 3.118 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.838742e-04 | 3.054 |
| R-HSA-9663891 | Selective autophagy | 8.838742e-04 | 3.054 |
| R-HSA-5620924 | Intraflagellar transport | 8.989288e-04 | 3.046 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.743286e-04 | 3.011 |
| R-HSA-913531 | Interferon Signaling | 9.961073e-04 | 3.002 |
| R-HSA-1500931 | Cell-Cell communication | 1.039562e-03 | 2.983 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.360597e-03 | 2.866 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.360597e-03 | 2.866 |
| R-HSA-75893 | TNF signaling | 1.464678e-03 | 2.834 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.722762e-03 | 2.764 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.596423e-03 | 2.797 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.316288e-03 | 2.635 |
| R-HSA-373760 | L1CAM interactions | 3.144238e-03 | 2.502 |
| R-HSA-390522 | Striated Muscle Contraction | 3.547866e-03 | 2.450 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.686942e-03 | 2.433 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.619144e-03 | 2.441 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 3.801005e-03 | 2.420 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.921776e-03 | 2.407 |
| R-HSA-112316 | Neuronal System | 3.956935e-03 | 2.403 |
| R-HSA-5617833 | Cilium Assembly | 5.170595e-03 | 2.286 |
| R-HSA-69275 | G2/M Transition | 4.716444e-03 | 2.326 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.939678e-03 | 2.306 |
| R-HSA-162582 | Signal Transduction | 5.092612e-03 | 2.293 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.408424e-03 | 2.267 |
| R-HSA-9609690 | HCMV Early Events | 5.910983e-03 | 2.228 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.539635e-03 | 2.184 |
| R-HSA-1632852 | Macroautophagy | 7.071791e-03 | 2.150 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 7.486199e-03 | 2.126 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.429968e-03 | 2.074 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 8.092270e-03 | 2.092 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 9.208723e-03 | 2.036 |
| R-HSA-73887 | Death Receptor Signaling | 9.959364e-03 | 2.002 |
| R-HSA-9612973 | Autophagy | 1.042915e-02 | 1.982 |
| R-HSA-422475 | Axon guidance | 1.057916e-02 | 1.976 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 1.114040e-02 | 1.953 |
| R-HSA-2028269 | Signaling by Hippo | 1.216731e-02 | 1.915 |
| R-HSA-9827857 | Specification of primordial germ cells | 1.216731e-02 | 1.915 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.246036e-02 | 1.904 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 1.491681e-02 | 1.826 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.468508e-02 | 1.833 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.548452e-02 | 1.810 |
| R-HSA-9675108 | Nervous system development | 1.584001e-02 | 1.800 |
| R-HSA-9609646 | HCMV Infection | 1.668934e-02 | 1.778 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.788671e-02 | 1.747 |
| R-HSA-5693538 | Homology Directed Repair | 1.799636e-02 | 1.745 |
| R-HSA-5688426 | Deubiquitination | 1.808522e-02 | 1.743 |
| R-HSA-3000170 | Syndecan interactions | 2.043568e-02 | 1.690 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 2.229226e-02 | 1.652 |
| R-HSA-68877 | Mitotic Prometaphase | 2.243223e-02 | 1.649 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.437941e-02 | 1.613 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.411911e-02 | 1.618 |
| R-HSA-1474165 | Reproduction | 2.488993e-02 | 1.604 |
| R-HSA-73894 | DNA Repair | 2.512620e-02 | 1.600 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.533636e-02 | 1.596 |
| R-HSA-9824446 | Viral Infection Pathways | 2.560527e-02 | 1.592 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.595473e-02 | 1.586 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.595473e-02 | 1.586 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.620842e-02 | 1.582 |
| R-HSA-6806834 | Signaling by MET | 2.918247e-02 | 1.535 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.002819e-02 | 1.522 |
| R-HSA-8875791 | MET activates STAT3 | 3.687924e-02 | 1.433 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 3.687924e-02 | 1.433 |
| R-HSA-198745 | Signalling to STAT3 | 3.687924e-02 | 1.433 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.686803e-02 | 1.433 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.353955e-02 | 1.474 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.359534e-02 | 1.474 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 3.687924e-02 | 1.433 |
| R-HSA-195721 | Signaling by WNT | 3.350185e-02 | 1.475 |
| R-HSA-68882 | Mitotic Anaphase | 3.336327e-02 | 1.477 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.387943e-02 | 1.470 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.359534e-02 | 1.474 |
| R-HSA-109582 | Hemostasis | 4.041369e-02 | 1.393 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.070933e-02 | 1.390 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.376097e-02 | 1.359 |
| R-HSA-419037 | NCAM1 interactions | 4.376097e-02 | 1.359 |
| R-HSA-191650 | Regulation of gap junction activity | 4.409158e-02 | 1.356 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 4.409158e-02 | 1.356 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 4.555361e-02 | 1.341 |
| R-HSA-71336 | Pentose phosphate pathway | 4.737300e-02 | 1.324 |
| R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 6.540879e-02 | 1.184 |
| R-HSA-3656243 | Defective ST3GAL3 causes MCT12 and EIEE15 | 6.540879e-02 | 1.184 |
| R-HSA-3656225 | Defective CHST6 causes MCDC1 | 6.540879e-02 | 1.184 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 9.310002e-02 | 1.031 |
| R-HSA-4839744 | Signaling by APC mutants | 9.989472e-02 | 1.000 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 9.989472e-02 | 1.000 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 9.989472e-02 | 1.000 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 9.989472e-02 | 1.000 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 9.989472e-02 | 1.000 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.066389e-01 | 0.972 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.066389e-01 | 0.972 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.133330e-01 | 0.946 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.133330e-01 | 0.946 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 1.199774e-01 | 0.921 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.331183e-01 | 0.876 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 1.331183e-01 | 0.876 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.331183e-01 | 0.876 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.460645e-01 | 0.835 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 1.588190e-01 | 0.799 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.651253e-01 | 0.782 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 5.298676e-02 | 1.276 |
| R-HSA-167161 | HIV Transcription Initiation | 5.298676e-02 | 1.276 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 5.298676e-02 | 1.276 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 1.713846e-01 | 0.766 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.713846e-01 | 0.766 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.713846e-01 | 0.766 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.713846e-01 | 0.766 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.713846e-01 | 0.766 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 5.685413e-02 | 1.245 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.081700e-02 | 1.216 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.837640e-01 | 0.736 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.837640e-01 | 0.736 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.959599e-01 | 0.708 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.959599e-01 | 0.708 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 7.538718e-02 | 1.123 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.079751e-01 | 0.682 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.198122e-01 | 0.658 |
| R-HSA-5334118 | DNA methylation | 2.314739e-01 | 0.635 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.314739e-01 | 0.635 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.002051e-01 | 0.999 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.002051e-01 | 0.999 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.073235e-01 | 0.969 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.244276e-01 | 0.905 |
| R-HSA-380287 | Centrosome maturation | 1.294297e-01 | 0.888 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.603328e-01 | 0.795 |
| R-HSA-156902 | Peptide chain elongation | 1.656102e-01 | 0.781 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.252435e-01 | 0.647 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.160786e-01 | 0.665 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.709181e-01 | 0.767 |
| R-HSA-72086 | mRNA Capping | 2.314739e-01 | 0.635 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.921864e-02 | 1.308 |
| R-HSA-173107 | Binding and entry of HIV virion | 9.310002e-02 | 1.031 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.198122e-01 | 0.658 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.093487e-02 | 1.041 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.169867e-01 | 0.664 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.169867e-01 | 0.664 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.524656e-01 | 0.817 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 5.125036e-02 | 1.290 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.460645e-01 | 0.835 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.097259e-01 | 0.960 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.005567e-02 | 1.155 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.421325e-01 | 0.847 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.194746e-01 | 0.923 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.884873e-01 | 0.725 |
| R-HSA-1500620 | Meiosis | 1.550879e-01 | 0.809 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.789324e-01 | 0.747 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.197360e-01 | 0.658 |
| R-HSA-167172 | Transcription of the HIV genome | 1.121426e-01 | 0.950 |
| R-HSA-9020933 | Interleukin-23 signaling | 7.935765e-02 | 1.100 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 9.310002e-02 | 1.031 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.066389e-01 | 0.972 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.066389e-01 | 0.972 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.331183e-01 | 0.876 |
| R-HSA-164378 | PKA activation in glucagon signalling | 1.588190e-01 | 0.799 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 1.588190e-01 | 0.799 |
| R-HSA-912446 | Meiotic recombination | 7.324255e-02 | 1.135 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.019899e-01 | 0.695 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.198122e-01 | 0.658 |
| R-HSA-8949613 | Cristae formation | 2.198122e-01 | 0.658 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.256648e-01 | 0.647 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.370190e-01 | 0.863 |
| R-HSA-8854691 | Interleukin-20 family signaling | 1.959599e-01 | 0.708 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.837640e-01 | 0.736 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.073235e-01 | 0.969 |
| R-HSA-9620244 | Long-term potentiation | 2.079751e-01 | 0.682 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.314739e-01 | 0.635 |
| R-HSA-5358508 | Mismatch Repair | 1.588190e-01 | 0.799 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 1.121426e-01 | 0.950 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 8.625446e-02 | 1.064 |
| R-HSA-9020958 | Interleukin-21 signaling | 8.625446e-02 | 1.064 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 9.310002e-02 | 1.031 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.265723e-01 | 0.898 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.898847e-01 | 0.722 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.319482e-01 | 0.880 |
| R-HSA-8985947 | Interleukin-9 signaling | 7.935765e-02 | 1.100 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.133330e-01 | 0.946 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.199774e-01 | 0.921 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.898847e-01 | 0.722 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 8.625446e-02 | 1.064 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.066389e-01 | 0.972 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.331183e-01 | 0.876 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 1.396156e-01 | 0.855 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.775974e-01 | 0.751 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.775974e-01 | 0.751 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.256648e-01 | 0.647 |
| R-HSA-3214847 | HATs acetylate histones | 5.071400e-02 | 1.295 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.524783e-01 | 0.817 |
| R-HSA-112040 | G-protein mediated events | 1.097259e-01 | 0.960 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.693242e-02 | 1.174 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.199774e-01 | 0.921 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.133330e-01 | 0.946 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.460645e-01 | 0.835 |
| R-HSA-2022857 | Keratan sulfate degradation | 1.713846e-01 | 0.766 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.198122e-01 | 0.658 |
| R-HSA-1474290 | Collagen formation | 1.843075e-01 | 0.734 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.524783e-01 | 0.817 |
| R-HSA-2586552 | Signaling by Leptin | 9.310002e-02 | 1.031 |
| R-HSA-162587 | HIV Life Cycle | 1.454751e-01 | 0.837 |
| R-HSA-9020956 | Interleukin-27 signaling | 9.310002e-02 | 1.031 |
| R-HSA-163615 | PKA activation | 1.588190e-01 | 0.799 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.490827e-02 | 1.260 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.837640e-01 | 0.736 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 1.898847e-01 | 0.722 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 1.959599e-01 | 0.708 |
| R-HSA-9839394 | TGFBR3 expression | 2.079751e-01 | 0.682 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.089304e-01 | 0.963 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.269227e-01 | 0.896 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.435878e-01 | 0.843 |
| R-HSA-111885 | Opioid Signalling | 2.142406e-01 | 0.669 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 8.625446e-02 | 1.064 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.372397e-01 | 0.625 |
| R-HSA-68886 | M Phase | 8.421284e-02 | 1.075 |
| R-HSA-9675135 | Diseases of DNA repair | 6.283311e-02 | 1.202 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 5.835597e-02 | 1.234 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 7.240923e-02 | 1.140 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 7.935765e-02 | 1.100 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 9.989472e-02 | 1.000 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 1.265723e-01 | 0.898 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.713846e-01 | 0.766 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.837640e-01 | 0.736 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.256648e-01 | 0.647 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.087590e-01 | 0.680 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.151439e-01 | 0.939 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 9.786315e-02 | 1.009 |
| R-HSA-4086398 | Ca2+ pathway | 1.244276e-01 | 0.905 |
| R-HSA-3928664 | Ephrin signaling | 1.588190e-01 | 0.799 |
| R-HSA-6783589 | Interleukin-6 family signaling | 2.019899e-01 | 0.695 |
| R-HSA-157579 | Telomere Maintenance | 1.951261e-01 | 0.710 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.199774e-01 | 0.921 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.524656e-01 | 0.817 |
| R-HSA-1181150 | Signaling by NODAL | 1.713846e-01 | 0.766 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.019899e-01 | 0.695 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.139158e-01 | 0.670 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.256648e-01 | 0.647 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.252700e-01 | 0.902 |
| R-HSA-422356 | Regulation of insulin secretion | 4.960502e-02 | 1.304 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.775974e-01 | 0.751 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.898847e-01 | 0.722 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.524783e-01 | 0.817 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 9.310002e-02 | 1.031 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.331183e-01 | 0.876 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.331183e-01 | 0.876 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.331183e-01 | 0.876 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 1.775974e-01 | 0.751 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.198122e-01 | 0.658 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.577061e-01 | 0.802 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.007066e-01 | 0.697 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.472864e-01 | 0.832 |
| R-HSA-4839726 | Chromatin organization | 1.452265e-01 | 0.838 |
| R-HSA-1640170 | Cell Cycle | 9.884006e-02 | 1.005 |
| R-HSA-193144 | Estrogen biosynthesis | 1.133330e-01 | 0.946 |
| R-HSA-112043 | PLC beta mediated events | 9.553721e-02 | 1.020 |
| R-HSA-69481 | G2/M Checkpoints | 9.221759e-02 | 1.035 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.760880e-01 | 0.754 |
| R-HSA-199991 | Membrane Trafficking | 6.569358e-02 | 1.182 |
| R-HSA-8984722 | Interleukin-35 Signalling | 1.133330e-01 | 0.946 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.079751e-01 | 0.682 |
| R-HSA-397014 | Muscle contraction | 9.835445e-02 | 1.007 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.625446e-02 | 1.064 |
| R-HSA-8876725 | Protein methylation | 1.331183e-01 | 0.876 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.460645e-01 | 0.835 |
| R-HSA-163685 | Integration of energy metabolism | 1.089304e-01 | 0.963 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.539898e-01 | 0.813 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.314739e-01 | 0.635 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.720509e-01 | 0.764 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.935765e-02 | 1.100 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.651253e-01 | 0.782 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.170173e-01 | 0.932 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 9.786315e-02 | 1.009 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.948729e-01 | 0.710 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.713846e-01 | 0.766 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.603328e-01 | 0.795 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.588190e-01 | 0.799 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.959599e-01 | 0.708 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.372397e-01 | 0.625 |
| R-HSA-8983711 | OAS antiviral response | 1.133330e-01 | 0.946 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.079751e-01 | 0.682 |
| R-HSA-186797 | Signaling by PDGF | 9.786315e-02 | 1.009 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.507421e-01 | 0.822 |
| R-HSA-446728 | Cell junction organization | 1.869817e-01 | 0.728 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.294297e-01 | 0.888 |
| R-HSA-211000 | Gene Silencing by RNA | 2.252435e-01 | 0.647 |
| R-HSA-3322077 | Glycogen synthesis | 1.713846e-01 | 0.766 |
| R-HSA-5663205 | Infectious disease | 1.424419e-01 | 0.846 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.224883e-01 | 0.653 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.603328e-01 | 0.795 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.762543e-01 | 0.754 |
| R-HSA-72172 | mRNA Splicing | 2.377482e-01 | 0.624 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.409247e-01 | 0.618 |
| R-HSA-186763 | Downstream signal transduction | 2.429626e-01 | 0.614 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.445932e-01 | 0.612 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.486429e-01 | 0.604 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.486429e-01 | 0.604 |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 2.542810e-01 | 0.595 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.542810e-01 | 0.595 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.542810e-01 | 0.595 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.542810e-01 | 0.595 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.542810e-01 | 0.595 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.542810e-01 | 0.595 |
| R-HSA-397795 | G-protein beta:gamma signalling | 2.542810e-01 | 0.595 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.542810e-01 | 0.595 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.542810e-01 | 0.595 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.542810e-01 | 0.595 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.542810e-01 | 0.595 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.584587e-01 | 0.588 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.598771e-01 | 0.585 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 2.598771e-01 | 0.585 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.598771e-01 | 0.585 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 2.598771e-01 | 0.585 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.654316e-01 | 0.576 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.654316e-01 | 0.576 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.654316e-01 | 0.576 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.654316e-01 | 0.576 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.654316e-01 | 0.576 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.654316e-01 | 0.576 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.654316e-01 | 0.576 |
| R-HSA-73886 | Chromosome Maintenance | 2.695613e-01 | 0.569 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.709447e-01 | 0.567 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.709447e-01 | 0.567 |
| R-HSA-1474244 | Extracellular matrix organization | 2.712822e-01 | 0.567 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.764167e-01 | 0.558 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.764167e-01 | 0.558 |
| R-HSA-111933 | Calmodulin induced events | 2.764167e-01 | 0.558 |
| R-HSA-111997 | CaM pathway | 2.764167e-01 | 0.558 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.818481e-01 | 0.550 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.818481e-01 | 0.550 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.818481e-01 | 0.550 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.818481e-01 | 0.550 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.818481e-01 | 0.550 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 2.818481e-01 | 0.550 |
| R-HSA-8948216 | Collagen chain trimerization | 2.818481e-01 | 0.550 |
| R-HSA-162906 | HIV Infection | 2.841074e-01 | 0.547 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.872390e-01 | 0.542 |
| R-HSA-73927 | Depurination | 2.872390e-01 | 0.542 |
| R-HSA-8875878 | MET promotes cell motility | 2.872390e-01 | 0.542 |
| R-HSA-6798695 | Neutrophil degranulation | 2.907852e-01 | 0.536 |
| R-HSA-201556 | Signaling by ALK | 2.925898e-01 | 0.534 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.925898e-01 | 0.534 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.925898e-01 | 0.534 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.979007e-01 | 0.526 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.979007e-01 | 0.526 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.979007e-01 | 0.526 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.979007e-01 | 0.526 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.979007e-01 | 0.526 |
| R-HSA-167169 | HIV Transcription Elongation | 2.979007e-01 | 0.526 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.979007e-01 | 0.526 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.979007e-01 | 0.526 |
| R-HSA-8982491 | Glycogen metabolism | 2.979007e-01 | 0.526 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.031721e-01 | 0.518 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.031721e-01 | 0.518 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.031721e-01 | 0.518 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.031721e-01 | 0.518 |
| R-HSA-8939211 | ESR-mediated signaling | 3.045338e-01 | 0.516 |
| R-HSA-1643685 | Disease | 3.055861e-01 | 0.515 |
| R-HSA-1266738 | Developmental Biology | 3.078099e-01 | 0.512 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.084042e-01 | 0.511 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.084042e-01 | 0.511 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.084042e-01 | 0.511 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.084042e-01 | 0.511 |
| R-HSA-991365 | Activation of GABAB receptors | 3.135974e-01 | 0.504 |
| R-HSA-977444 | GABA B receptor activation | 3.135974e-01 | 0.504 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.135974e-01 | 0.504 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.135974e-01 | 0.504 |
| R-HSA-73928 | Depyrimidination | 3.135974e-01 | 0.504 |
| R-HSA-111996 | Ca-dependent events | 3.135974e-01 | 0.504 |
| R-HSA-9710421 | Defective pyroptosis | 3.187519e-01 | 0.497 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.187519e-01 | 0.497 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.193660e-01 | 0.496 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.238680e-01 | 0.490 |
| R-HSA-69236 | G1 Phase | 3.238680e-01 | 0.490 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.238680e-01 | 0.490 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.276064e-01 | 0.485 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.289460e-01 | 0.483 |
| R-HSA-774815 | Nucleosome assembly | 3.289460e-01 | 0.483 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 3.289460e-01 | 0.483 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.289460e-01 | 0.483 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.289460e-01 | 0.483 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.289460e-01 | 0.483 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.339861e-01 | 0.476 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.339861e-01 | 0.476 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.339861e-01 | 0.476 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.339861e-01 | 0.476 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.339861e-01 | 0.476 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.339861e-01 | 0.476 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.339861e-01 | 0.476 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.339861e-01 | 0.476 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.339861e-01 | 0.476 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.385528e-01 | 0.470 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.389887e-01 | 0.470 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.439541e-01 | 0.463 |
| R-HSA-9634597 | GPER1 signaling | 3.439541e-01 | 0.463 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.475817e-01 | 0.459 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 3.488825e-01 | 0.457 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 3.488825e-01 | 0.457 |
| R-HSA-9758941 | Gastrulation | 3.575774e-01 | 0.447 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.586293e-01 | 0.445 |
| R-HSA-72187 | mRNA 3'-end processing | 3.634483e-01 | 0.440 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.634483e-01 | 0.440 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.634483e-01 | 0.440 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.634483e-01 | 0.440 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.634483e-01 | 0.440 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.634483e-01 | 0.440 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.656728e-01 | 0.437 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.656728e-01 | 0.437 |
| R-HSA-1221632 | Meiotic synapsis | 3.682314e-01 | 0.434 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.682314e-01 | 0.434 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.682314e-01 | 0.434 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.729789e-01 | 0.428 |
| R-HSA-156588 | Glucuronidation | 3.729789e-01 | 0.428 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.776910e-01 | 0.423 |
| R-HSA-418597 | G alpha (z) signalling events | 3.776910e-01 | 0.423 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.823679e-01 | 0.418 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.823679e-01 | 0.418 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.823679e-01 | 0.418 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.823679e-01 | 0.418 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.823679e-01 | 0.418 |
| R-HSA-597592 | Post-translational protein modification | 3.832211e-01 | 0.417 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.916175e-01 | 0.407 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.916175e-01 | 0.407 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.961907e-01 | 0.402 |
| R-HSA-180786 | Extension of Telomeres | 3.961907e-01 | 0.402 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.007297e-01 | 0.397 |
| R-HSA-977443 | GABA receptor activation | 4.007297e-01 | 0.397 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.007297e-01 | 0.397 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.007297e-01 | 0.397 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.052349e-01 | 0.392 |
| R-HSA-445717 | Aquaporin-mediated transport | 4.052349e-01 | 0.392 |
| R-HSA-450294 | MAP kinase activation | 4.052349e-01 | 0.392 |
| R-HSA-1442490 | Collagen degradation | 4.052349e-01 | 0.392 |
| R-HSA-1280218 | Adaptive Immune System | 4.099368e-01 | 0.387 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.141448e-01 | 0.383 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.141448e-01 | 0.383 |
| R-HSA-8848021 | Signaling by PTK6 | 4.141448e-01 | 0.383 |
| R-HSA-373755 | Semaphorin interactions | 4.141448e-01 | 0.383 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.185500e-01 | 0.378 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.211432e-01 | 0.376 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.229223e-01 | 0.374 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.237257e-01 | 0.373 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.237257e-01 | 0.373 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.288730e-01 | 0.368 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.315694e-01 | 0.365 |
| R-HSA-196071 | Metabolism of steroid hormones | 4.315694e-01 | 0.365 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.358446e-01 | 0.361 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.358446e-01 | 0.361 |
| R-HSA-168255 | Influenza Infection | 4.390956e-01 | 0.357 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.442996e-01 | 0.352 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.442996e-01 | 0.352 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.442996e-01 | 0.352 |
| R-HSA-448424 | Interleukin-17 signaling | 4.442996e-01 | 0.352 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.442996e-01 | 0.352 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.484799e-01 | 0.348 |
| R-HSA-3000178 | ECM proteoglycans | 4.484799e-01 | 0.348 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.526290e-01 | 0.344 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.526290e-01 | 0.344 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.526290e-01 | 0.344 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.567471e-01 | 0.340 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.608345e-01 | 0.336 |
| R-HSA-392499 | Metabolism of proteins | 4.638716e-01 | 0.334 |
| R-HSA-8953854 | Metabolism of RNA | 4.646108e-01 | 0.333 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.648913e-01 | 0.333 |
| R-HSA-8852135 | Protein ubiquitination | 4.648913e-01 | 0.333 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.648913e-01 | 0.333 |
| R-HSA-5689603 | UCH proteinases | 4.689180e-01 | 0.329 |
| R-HSA-6783783 | Interleukin-10 signaling | 4.768812e-01 | 0.322 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.768812e-01 | 0.322 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.768812e-01 | 0.322 |
| R-HSA-216083 | Integrin cell surface interactions | 4.768812e-01 | 0.322 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.808184e-01 | 0.318 |
| R-HSA-9659379 | Sensory processing of sound | 4.808184e-01 | 0.318 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.814019e-01 | 0.317 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.816730e-01 | 0.317 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.847261e-01 | 0.315 |
| R-HSA-977225 | Amyloid fiber formation | 4.886046e-01 | 0.311 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.910734e-01 | 0.309 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.924542e-01 | 0.308 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.962751e-01 | 0.304 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.978584e-01 | 0.303 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.982533e-01 | 0.303 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.038315e-01 | 0.298 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.038315e-01 | 0.298 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.112754e-01 | 0.291 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.149557e-01 | 0.288 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.186085e-01 | 0.285 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.199730e-01 | 0.284 |
| R-HSA-202424 | Downstream TCR signaling | 5.258326e-01 | 0.279 |
| R-HSA-73884 | Base Excision Repair | 5.258326e-01 | 0.279 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.258326e-01 | 0.279 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.294042e-01 | 0.276 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.294042e-01 | 0.276 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.329491e-01 | 0.273 |
| R-HSA-418990 | Adherens junctions interactions | 5.354472e-01 | 0.271 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.364675e-01 | 0.270 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.399596e-01 | 0.268 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.434257e-01 | 0.265 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.468658e-01 | 0.262 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.502802e-01 | 0.259 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.502802e-01 | 0.259 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.502802e-01 | 0.259 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.513716e-01 | 0.259 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.536691e-01 | 0.257 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.570327e-01 | 0.254 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.577274e-01 | 0.254 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.603712e-01 | 0.252 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.603712e-01 | 0.252 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.603712e-01 | 0.252 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.636847e-01 | 0.249 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.702375e-01 | 0.244 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.702375e-01 | 0.244 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.734773e-01 | 0.241 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.752773e-01 | 0.240 |
| R-HSA-192823 | Viral mRNA Translation | 5.766928e-01 | 0.239 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.798843e-01 | 0.237 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.798843e-01 | 0.237 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.861958e-01 | 0.232 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.924133e-01 | 0.227 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.924133e-01 | 0.227 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.954872e-01 | 0.225 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.954872e-01 | 0.225 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.954872e-01 | 0.225 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.985381e-01 | 0.223 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.985381e-01 | 0.223 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.015662e-01 | 0.221 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.015662e-01 | 0.221 |
| R-HSA-202403 | TCR signaling | 6.015662e-01 | 0.221 |
| R-HSA-6803157 | Antimicrobial peptides | 6.045716e-01 | 0.219 |
| R-HSA-421270 | Cell-cell junction organization | 6.060750e-01 | 0.217 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.075546e-01 | 0.216 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.075546e-01 | 0.216 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.075546e-01 | 0.216 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.105152e-01 | 0.214 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.105152e-01 | 0.214 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.160467e-01 | 0.210 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.192649e-01 | 0.208 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.221379e-01 | 0.206 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.249894e-01 | 0.204 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.249894e-01 | 0.204 |
| R-HSA-418594 | G alpha (i) signalling events | 6.268346e-01 | 0.203 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.278196e-01 | 0.202 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.296840e-01 | 0.201 |
| R-HSA-9679506 | SARS-CoV Infections | 6.322012e-01 | 0.199 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.334165e-01 | 0.198 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.334165e-01 | 0.198 |
| R-HSA-68875 | Mitotic Prophase | 6.361836e-01 | 0.196 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.389300e-01 | 0.195 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.391950e-01 | 0.194 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.416558e-01 | 0.193 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.416558e-01 | 0.193 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.443612e-01 | 0.191 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 6.443612e-01 | 0.191 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.523564e-01 | 0.186 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.523564e-01 | 0.186 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.523564e-01 | 0.186 |
| R-HSA-194138 | Signaling by VEGF | 6.523564e-01 | 0.186 |
| R-HSA-69206 | G1/S Transition | 6.523564e-01 | 0.186 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.549817e-01 | 0.184 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.601734e-01 | 0.180 |
| R-HSA-72766 | Translation | 6.604557e-01 | 0.180 |
| R-HSA-9717189 | Sensory perception of taste | 6.703255e-01 | 0.174 |
| R-HSA-5576891 | Cardiac conduction | 6.703255e-01 | 0.174 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.728161e-01 | 0.172 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.770711e-01 | 0.169 |
| R-HSA-5173105 | O-linked glycosylation | 6.873730e-01 | 0.163 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.889646e-01 | 0.162 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.897359e-01 | 0.161 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.012873e-01 | 0.154 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.035459e-01 | 0.153 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.057876e-01 | 0.151 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.102205e-01 | 0.149 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.145873e-01 | 0.146 |
| R-HSA-69242 | S Phase | 7.145873e-01 | 0.146 |
| R-HSA-166520 | Signaling by NTRKs | 7.145873e-01 | 0.146 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.210153e-01 | 0.142 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.231259e-01 | 0.141 |
| R-HSA-69306 | DNA Replication | 7.252207e-01 | 0.140 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.272997e-01 | 0.138 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.293632e-01 | 0.137 |
| R-HSA-1989781 | PPARA activates gene expression | 7.293632e-01 | 0.137 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.315288e-01 | 0.136 |
| R-HSA-8957322 | Metabolism of steroids | 7.330069e-01 | 0.135 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.334437e-01 | 0.135 |
| R-HSA-9711097 | Cellular response to starvation | 7.354610e-01 | 0.133 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.354610e-01 | 0.133 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.394504e-01 | 0.131 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.472510e-01 | 0.127 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.528195e-01 | 0.123 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.603487e-01 | 0.119 |
| R-HSA-418555 | G alpha (s) signalling events | 7.621640e-01 | 0.118 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.621640e-01 | 0.118 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.657538e-01 | 0.116 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.657538e-01 | 0.116 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.677850e-01 | 0.115 |
| R-HSA-3781865 | Diseases of glycosylation | 7.845581e-01 | 0.105 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.878126e-01 | 0.104 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.910182e-01 | 0.102 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.957369e-01 | 0.099 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.972862e-01 | 0.098 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 7.988238e-01 | 0.098 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.135779e-01 | 0.090 |
| R-HSA-74160 | Gene expression (Transcription) | 8.294522e-01 | 0.081 |
| R-HSA-212436 | Generic Transcription Pathway | 8.462778e-01 | 0.072 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.482672e-01 | 0.071 |
| R-HSA-72312 | rRNA processing | 8.517022e-01 | 0.070 |
| R-HSA-388396 | GPCR downstream signalling | 8.531765e-01 | 0.069 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.594202e-01 | 0.066 |
| R-HSA-157118 | Signaling by NOTCH | 8.604897e-01 | 0.065 |
| R-HSA-168256 | Immune System | 8.606081e-01 | 0.065 |
| R-HSA-416476 | G alpha (q) signalling events | 8.838711e-01 | 0.054 |
| R-HSA-168249 | Innate Immune System | 8.892535e-01 | 0.051 |
| R-HSA-9658195 | Leishmania infection | 8.980383e-01 | 0.047 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.980383e-01 | 0.047 |
| R-HSA-372790 | Signaling by GPCR | 9.011484e-01 | 0.045 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.356532e-01 | 0.029 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.361459e-01 | 0.029 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.562123e-01 | 0.019 |
| R-HSA-449147 | Signaling by Interleukins | 9.572747e-01 | 0.019 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.575424e-01 | 0.019 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.585136e-01 | 0.018 |
| R-HSA-5668914 | Diseases of metabolism | 9.670921e-01 | 0.015 |
| R-HSA-382551 | Transport of small molecules | 9.827545e-01 | 0.008 |
| R-HSA-211859 | Biological oxidations | 9.843663e-01 | 0.007 |
| R-HSA-500792 | GPCR ligand binding | 9.906529e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.925489e-01 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 9.994019e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999088e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999875e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.800 | 0.004 | 2 | 0.416 |
MST4 |
0.792 | 0.184 | 2 | 0.540 |
CDC7 |
0.792 | 0.107 | 1 | 0.727 |
NDR2 |
0.790 | 0.135 | -3 | 0.837 |
PRKD1 |
0.790 | 0.134 | -3 | 0.800 |
NLK |
0.789 | 0.086 | 1 | 0.786 |
ERK5 |
0.788 | 0.113 | 1 | 0.738 |
ULK2 |
0.788 | -0.055 | 2 | 0.386 |
PRPK |
0.787 | -0.025 | -1 | 0.813 |
GCN2 |
0.787 | -0.048 | 2 | 0.400 |
IKKB |
0.787 | 0.011 | -2 | 0.737 |
TBK1 |
0.786 | -0.001 | 1 | 0.763 |
PKN3 |
0.785 | 0.045 | -3 | 0.832 |
PRKD2 |
0.785 | 0.103 | -3 | 0.784 |
HIPK4 |
0.785 | 0.104 | 1 | 0.762 |
PDHK1 |
0.784 | 0.096 | 1 | 0.814 |
RAF1 |
0.783 | -0.007 | 1 | 0.800 |
IKKE |
0.782 | -0.016 | 1 | 0.753 |
IKKA |
0.782 | 0.071 | -2 | 0.729 |
PDHK4 |
0.782 | -0.041 | 1 | 0.826 |
CAMK1B |
0.782 | 0.008 | -3 | 0.879 |
CAMK2G |
0.781 | -0.053 | 2 | 0.390 |
NEK6 |
0.781 | 0.025 | -2 | 0.758 |
DSTYK |
0.780 | -0.054 | 2 | 0.419 |
PKCD |
0.780 | 0.013 | 2 | 0.386 |
TGFBR2 |
0.780 | 0.035 | -2 | 0.686 |
NUAK2 |
0.780 | 0.064 | -3 | 0.855 |
MOS |
0.780 | -0.007 | 1 | 0.769 |
PKN2 |
0.780 | 0.025 | -3 | 0.860 |
MTOR |
0.780 | -0.065 | 1 | 0.793 |
CLK3 |
0.780 | 0.041 | 1 | 0.752 |
WNK1 |
0.779 | 0.030 | -2 | 0.746 |
CDKL1 |
0.779 | 0.010 | -3 | 0.806 |
NDR1 |
0.779 | 0.039 | -3 | 0.842 |
RSK2 |
0.778 | 0.047 | -3 | 0.785 |
PIM3 |
0.778 | -0.011 | -3 | 0.830 |
RIPK3 |
0.778 | -0.000 | 3 | 0.763 |
MLK1 |
0.778 | -0.040 | 2 | 0.406 |
CDKL5 |
0.778 | 0.034 | -3 | 0.789 |
RSK3 |
0.777 | 0.047 | -3 | 0.773 |
NEK7 |
0.777 | -0.022 | -3 | 0.809 |
CAMK2D |
0.777 | 0.025 | -3 | 0.840 |
BCKDK |
0.777 | 0.004 | -1 | 0.772 |
TSSK1 |
0.777 | 0.121 | -3 | 0.865 |
ATR |
0.776 | -0.024 | 1 | 0.779 |
CHAK2 |
0.776 | -0.010 | -1 | 0.767 |
KIS |
0.776 | 0.030 | 1 | 0.645 |
NIK |
0.776 | 0.005 | -3 | 0.889 |
MLK3 |
0.776 | -0.013 | 2 | 0.369 |
BMPR2 |
0.776 | -0.083 | -2 | 0.793 |
NUAK1 |
0.776 | 0.079 | -3 | 0.816 |
ULK1 |
0.776 | -0.105 | -3 | 0.783 |
NEK9 |
0.776 | 0.020 | 2 | 0.444 |
MELK |
0.775 | 0.072 | -3 | 0.821 |
P90RSK |
0.775 | 0.032 | -3 | 0.770 |
AMPKA1 |
0.775 | 0.042 | -3 | 0.858 |
MARK4 |
0.775 | -0.006 | 4 | 0.809 |
PHKG1 |
0.775 | 0.056 | -3 | 0.837 |
LATS2 |
0.775 | 0.051 | -5 | 0.698 |
MLK2 |
0.774 | -0.007 | 2 | 0.410 |
PRKD3 |
0.774 | 0.074 | -3 | 0.770 |
NIM1 |
0.774 | -0.021 | 3 | 0.795 |
WNK3 |
0.773 | -0.039 | 1 | 0.810 |
P70S6KB |
0.773 | 0.032 | -3 | 0.817 |
PKR |
0.772 | 0.159 | 1 | 0.820 |
AMPKA2 |
0.772 | 0.047 | -3 | 0.836 |
AURC |
0.771 | 0.066 | -2 | 0.499 |
IRE1 |
0.771 | -0.028 | 1 | 0.794 |
TSSK2 |
0.771 | 0.003 | -5 | 0.796 |
ICK |
0.770 | 0.022 | -3 | 0.830 |
SRPK1 |
0.770 | 0.025 | -3 | 0.753 |
PIM1 |
0.769 | 0.016 | -3 | 0.799 |
CAMLCK |
0.769 | -0.031 | -2 | 0.725 |
SIK |
0.769 | 0.045 | -3 | 0.790 |
PKCA |
0.769 | -0.012 | 2 | 0.363 |
MAPKAPK3 |
0.769 | 0.013 | -3 | 0.771 |
CDK8 |
0.769 | 0.026 | 1 | 0.606 |
SKMLCK |
0.768 | -0.044 | -2 | 0.693 |
TTBK2 |
0.768 | -0.098 | 2 | 0.366 |
GRK1 |
0.768 | -0.016 | -2 | 0.695 |
RIPK1 |
0.768 | -0.035 | 1 | 0.846 |
MAPKAPK2 |
0.768 | 0.048 | -3 | 0.738 |
ANKRD3 |
0.767 | -0.061 | 1 | 0.848 |
PKCB |
0.767 | -0.018 | 2 | 0.356 |
FAM20C |
0.767 | -0.050 | 2 | 0.279 |
MASTL |
0.767 | -0.133 | -2 | 0.732 |
PKACG |
0.766 | 0.001 | -2 | 0.584 |
DAPK2 |
0.766 | -0.037 | -3 | 0.868 |
BRSK2 |
0.766 | 0.002 | -3 | 0.832 |
GRK5 |
0.766 | -0.094 | -3 | 0.858 |
QSK |
0.766 | 0.029 | 4 | 0.792 |
QIK |
0.765 | -0.021 | -3 | 0.850 |
CDK7 |
0.765 | 0.037 | 1 | 0.610 |
CAMK2B |
0.765 | -0.016 | 2 | 0.386 |
IRE2 |
0.765 | -0.064 | 2 | 0.352 |
PKCG |
0.765 | -0.042 | 2 | 0.353 |
HUNK |
0.764 | -0.118 | 2 | 0.356 |
PAK6 |
0.764 | 0.008 | -2 | 0.609 |
MLK4 |
0.764 | -0.064 | 2 | 0.352 |
JNK2 |
0.764 | 0.069 | 1 | 0.574 |
PAK1 |
0.764 | -0.033 | -2 | 0.634 |
PHKG2 |
0.764 | 0.044 | -3 | 0.850 |
RSK4 |
0.764 | 0.033 | -3 | 0.756 |
PAK3 |
0.764 | -0.049 | -2 | 0.648 |
CDK19 |
0.764 | 0.031 | 1 | 0.568 |
PKCZ |
0.764 | -0.020 | 2 | 0.384 |
GRK6 |
0.764 | -0.039 | 1 | 0.752 |
MNK2 |
0.763 | -0.001 | -2 | 0.643 |
PKCH |
0.763 | -0.038 | 2 | 0.339 |
CDK5 |
0.763 | 0.043 | 1 | 0.617 |
CHAK1 |
0.762 | -0.049 | 2 | 0.379 |
DLK |
0.762 | -0.099 | 1 | 0.788 |
CAMK4 |
0.762 | -0.025 | -3 | 0.852 |
BRSK1 |
0.762 | -0.017 | -3 | 0.807 |
CAMK2A |
0.762 | -0.020 | 2 | 0.376 |
MNK1 |
0.761 | 0.001 | -2 | 0.659 |
P38A |
0.761 | 0.058 | 1 | 0.653 |
MARK3 |
0.761 | 0.012 | 4 | 0.766 |
DCAMKL1 |
0.760 | 0.054 | -3 | 0.806 |
AURB |
0.760 | 0.027 | -2 | 0.498 |
YSK4 |
0.760 | -0.061 | 1 | 0.753 |
VRK2 |
0.760 | 0.010 | 1 | 0.829 |
PLK4 |
0.760 | -0.055 | 2 | 0.266 |
NEK2 |
0.760 | -0.044 | 2 | 0.417 |
CHK1 |
0.759 | 0.045 | -3 | 0.813 |
SRPK2 |
0.759 | 0.004 | -3 | 0.688 |
AKT2 |
0.759 | 0.048 | -3 | 0.719 |
P38B |
0.759 | 0.051 | 1 | 0.584 |
ERK1 |
0.759 | 0.048 | 1 | 0.582 |
LATS1 |
0.759 | -0.004 | -3 | 0.826 |
MARK2 |
0.759 | -0.000 | 4 | 0.728 |
DCAMKL2 |
0.759 | 0.032 | -3 | 0.837 |
CAMK1G |
0.758 | 0.004 | -3 | 0.795 |
ERK7 |
0.758 | 0.000 | 2 | 0.279 |
PERK |
0.758 | 0.006 | -2 | 0.768 |
SGK3 |
0.758 | 0.018 | -3 | 0.778 |
SMG1 |
0.758 | -0.001 | 1 | 0.739 |
CDK18 |
0.758 | 0.022 | 1 | 0.542 |
JNK3 |
0.758 | 0.038 | 1 | 0.612 |
TLK2 |
0.758 | 0.020 | 1 | 0.764 |
GRK4 |
0.758 | -0.111 | -2 | 0.708 |
PLK1 |
0.758 | -0.086 | -2 | 0.716 |
ERK2 |
0.758 | 0.034 | 1 | 0.638 |
ALK4 |
0.757 | -0.039 | -2 | 0.734 |
PKG2 |
0.757 | 0.005 | -2 | 0.524 |
P70S6K |
0.757 | 0.057 | -3 | 0.729 |
CDK1 |
0.757 | 0.028 | 1 | 0.568 |
IRAK4 |
0.757 | -0.018 | 1 | 0.811 |
P38D |
0.757 | 0.074 | 1 | 0.513 |
DYRK2 |
0.757 | -0.004 | 1 | 0.666 |
BMPR1B |
0.756 | 0.019 | 1 | 0.653 |
MEK1 |
0.756 | -0.113 | 2 | 0.390 |
TTBK1 |
0.756 | -0.051 | 2 | 0.315 |
PLK3 |
0.756 | -0.053 | 2 | 0.345 |
SNRK |
0.756 | -0.106 | 2 | 0.296 |
PKCT |
0.756 | -0.022 | 2 | 0.356 |
MST3 |
0.756 | 0.045 | 2 | 0.440 |
CDK13 |
0.755 | 0.011 | 1 | 0.595 |
PKACB |
0.755 | 0.020 | -2 | 0.508 |
ATM |
0.755 | -0.061 | 1 | 0.721 |
AKT1 |
0.755 | 0.051 | -3 | 0.734 |
PAK2 |
0.755 | -0.067 | -2 | 0.632 |
HIPK1 |
0.755 | 0.050 | 1 | 0.678 |
MARK1 |
0.755 | -0.016 | 4 | 0.776 |
DNAPK |
0.754 | -0.028 | 1 | 0.732 |
CDK17 |
0.754 | 0.018 | 1 | 0.493 |
HIPK2 |
0.754 | 0.059 | 1 | 0.580 |
TGFBR1 |
0.754 | -0.029 | -2 | 0.703 |
PKCI |
0.754 | -0.003 | 2 | 0.378 |
SRPK3 |
0.753 | -0.012 | -3 | 0.738 |
BRAF |
0.753 | -0.042 | -4 | 0.821 |
PIM2 |
0.753 | 0.017 | -3 | 0.771 |
MSK2 |
0.753 | -0.057 | -3 | 0.738 |
ZAK |
0.752 | -0.071 | 1 | 0.777 |
SSTK |
0.752 | -0.007 | 4 | 0.773 |
CDK2 |
0.752 | 0.003 | 1 | 0.642 |
HRI |
0.752 | -0.060 | -2 | 0.759 |
WNK4 |
0.752 | -0.009 | -2 | 0.759 |
P38G |
0.751 | 0.027 | 1 | 0.490 |
ACVR2A |
0.751 | -0.013 | -2 | 0.698 |
MEKK1 |
0.751 | -0.060 | 1 | 0.795 |
CLK4 |
0.751 | -0.002 | -3 | 0.791 |
GRK7 |
0.750 | -0.017 | 1 | 0.683 |
PKN1 |
0.750 | 0.036 | -3 | 0.750 |
NEK5 |
0.750 | -0.033 | 1 | 0.818 |
MYLK4 |
0.750 | -0.044 | -2 | 0.616 |
MEKK2 |
0.750 | -0.075 | 2 | 0.397 |
PRKX |
0.750 | 0.029 | -3 | 0.717 |
ACVR2B |
0.750 | -0.024 | -2 | 0.711 |
CLK1 |
0.750 | 0.009 | -3 | 0.786 |
TAO3 |
0.749 | 0.002 | 1 | 0.774 |
DRAK1 |
0.749 | -0.073 | 1 | 0.764 |
HIPK3 |
0.749 | 0.021 | 1 | 0.697 |
AURA |
0.749 | -0.000 | -2 | 0.461 |
CDK16 |
0.749 | 0.025 | 1 | 0.505 |
CDK9 |
0.749 | 0.011 | 1 | 0.608 |
CAMKK1 |
0.749 | 0.056 | -2 | 0.827 |
PINK1 |
0.748 | -0.079 | 1 | 0.777 |
MPSK1 |
0.748 | 0.041 | 1 | 0.717 |
PKCE |
0.748 | -0.004 | 2 | 0.348 |
ALK2 |
0.747 | -0.021 | -2 | 0.724 |
MEK5 |
0.747 | -0.130 | 2 | 0.402 |
DYRK1A |
0.747 | 0.011 | 1 | 0.704 |
CDK14 |
0.747 | 0.009 | 1 | 0.592 |
CAMKK2 |
0.746 | 0.095 | -2 | 0.813 |
MAPKAPK5 |
0.746 | -0.050 | -3 | 0.708 |
CDK12 |
0.746 | 0.003 | 1 | 0.579 |
BUB1 |
0.746 | 0.124 | -5 | 0.761 |
NEK8 |
0.746 | -0.041 | 2 | 0.400 |
PDK1 |
0.745 | 0.048 | 1 | 0.881 |
MSK1 |
0.745 | -0.040 | -3 | 0.744 |
CDK10 |
0.745 | 0.029 | 1 | 0.582 |
CDK3 |
0.745 | 0.036 | 1 | 0.505 |
MEKK3 |
0.744 | -0.151 | 1 | 0.783 |
LKB1 |
0.744 | 0.065 | -3 | 0.800 |
BMPR1A |
0.744 | 0.028 | 1 | 0.628 |
NEK11 |
0.743 | -0.057 | 1 | 0.824 |
TAO2 |
0.743 | -0.033 | 2 | 0.420 |
AKT3 |
0.743 | 0.046 | -3 | 0.646 |
PRP4 |
0.743 | -0.037 | -3 | 0.704 |
CAMK1D |
0.742 | 0.007 | -3 | 0.722 |
LOK |
0.742 | 0.036 | -2 | 0.696 |
HGK |
0.741 | 0.018 | 3 | 0.856 |
PKACA |
0.741 | 0.003 | -2 | 0.462 |
IRAK1 |
0.741 | -0.105 | -1 | 0.686 |
NEK4 |
0.740 | -0.014 | 1 | 0.794 |
MAP3K15 |
0.740 | -0.003 | 1 | 0.776 |
CK1G1 |
0.740 | -0.024 | -3 | 0.564 |
MINK |
0.740 | 0.027 | 1 | 0.787 |
PAK5 |
0.740 | -0.031 | -2 | 0.520 |
CLK2 |
0.740 | 0.004 | -3 | 0.765 |
SMMLCK |
0.740 | -0.064 | -3 | 0.842 |
GRK2 |
0.739 | -0.085 | -2 | 0.623 |
TLK1 |
0.739 | -0.111 | -2 | 0.698 |
PASK |
0.739 | -0.040 | -3 | 0.845 |
JNK1 |
0.738 | 0.030 | 1 | 0.550 |
PLK2 |
0.738 | -0.014 | -3 | 0.775 |
NEK1 |
0.738 | 0.034 | 1 | 0.805 |
CAMK1A |
0.737 | 0.024 | -3 | 0.705 |
TNIK |
0.737 | 0.017 | 3 | 0.854 |
STK33 |
0.737 | -0.084 | 2 | 0.302 |
MST2 |
0.737 | -0.071 | 1 | 0.768 |
DYRK1B |
0.736 | -0.010 | 1 | 0.614 |
YSK1 |
0.736 | 0.032 | 2 | 0.450 |
EEF2K |
0.736 | -0.031 | 3 | 0.826 |
GCK |
0.736 | -0.015 | 1 | 0.775 |
CK1E |
0.736 | -0.048 | -3 | 0.572 |
SLK |
0.736 | -0.011 | -2 | 0.639 |
GAK |
0.736 | -0.002 | 1 | 0.733 |
PAK4 |
0.736 | -0.045 | -2 | 0.512 |
CDK6 |
0.735 | 0.008 | 1 | 0.575 |
PDHK3_TYR |
0.735 | 0.027 | 4 | 0.822 |
MOK |
0.735 | 0.067 | 1 | 0.698 |
CHK2 |
0.734 | 0.017 | -3 | 0.678 |
LRRK2 |
0.734 | -0.045 | 2 | 0.422 |
MEKK6 |
0.734 | -0.051 | 1 | 0.760 |
SGK1 |
0.734 | 0.023 | -3 | 0.633 |
DYRK4 |
0.734 | -0.028 | 1 | 0.582 |
KHS1 |
0.734 | 0.035 | 1 | 0.783 |
GSK3B |
0.734 | -0.031 | 4 | 0.391 |
TAK1 |
0.734 | -0.038 | 1 | 0.786 |
MAK |
0.734 | 0.056 | -2 | 0.642 |
HPK1 |
0.733 | -0.010 | 1 | 0.780 |
NEK3 |
0.732 | 0.045 | 1 | 0.787 |
KHS2 |
0.732 | 0.027 | 1 | 0.787 |
DYRK3 |
0.732 | -0.030 | 1 | 0.695 |
MRCKA |
0.731 | 0.021 | -3 | 0.790 |
MRCKB |
0.731 | 0.016 | -3 | 0.779 |
CK1D |
0.731 | -0.027 | -3 | 0.526 |
CDK4 |
0.731 | 0.009 | 1 | 0.559 |
TESK1_TYR |
0.731 | -0.017 | 3 | 0.882 |
GSK3A |
0.730 | -0.025 | 4 | 0.398 |
LIMK2_TYR |
0.730 | 0.065 | -3 | 0.879 |
MST1 |
0.730 | -0.068 | 1 | 0.771 |
YANK3 |
0.729 | -0.035 | 2 | 0.220 |
ROCK2 |
0.728 | 0.011 | -3 | 0.803 |
CK1A2 |
0.728 | -0.031 | -3 | 0.530 |
PKMYT1_TYR |
0.728 | -0.007 | 3 | 0.864 |
RIPK2 |
0.727 | -0.114 | 1 | 0.767 |
GRK3 |
0.726 | -0.069 | -2 | 0.569 |
MAP2K4_TYR |
0.726 | -0.022 | -1 | 0.825 |
PBK |
0.726 | -0.000 | 1 | 0.655 |
MEK2 |
0.726 | -0.101 | 2 | 0.396 |
DAPK3 |
0.726 | -0.051 | -3 | 0.822 |
CRIK |
0.726 | 0.077 | -3 | 0.723 |
SBK |
0.725 | 0.018 | -3 | 0.608 |
VRK1 |
0.725 | -0.134 | 2 | 0.383 |
MAP2K7_TYR |
0.725 | -0.161 | 2 | 0.408 |
TYK2 |
0.724 | -0.008 | 1 | 0.787 |
PDHK4_TYR |
0.723 | -0.066 | 2 | 0.423 |
BMPR2_TYR |
0.723 | -0.053 | -1 | 0.814 |
DMPK1 |
0.722 | 0.020 | -3 | 0.814 |
JAK2 |
0.722 | -0.019 | 1 | 0.789 |
PINK1_TYR |
0.721 | -0.126 | 1 | 0.799 |
RET |
0.721 | -0.090 | 1 | 0.790 |
MAP2K6_TYR |
0.720 | -0.126 | -1 | 0.822 |
MYO3B |
0.720 | 0.001 | 2 | 0.436 |
OSR1 |
0.720 | -0.023 | 2 | 0.433 |
EPHA6 |
0.720 | -0.060 | -1 | 0.820 |
MST1R |
0.720 | -0.045 | 3 | 0.837 |
MYO3A |
0.720 | -0.016 | 1 | 0.802 |
JAK1 |
0.719 | 0.033 | 1 | 0.772 |
PKG1 |
0.719 | -0.028 | -2 | 0.450 |
ROS1 |
0.719 | -0.074 | 3 | 0.802 |
LIMK1_TYR |
0.718 | -0.107 | 2 | 0.416 |
PDHK1_TYR |
0.718 | -0.133 | -1 | 0.833 |
TAO1 |
0.718 | -0.034 | 1 | 0.750 |
CK2A2 |
0.718 | -0.049 | 1 | 0.580 |
NEK10_TYR |
0.717 | 0.058 | 1 | 0.709 |
CSF1R |
0.717 | -0.070 | 3 | 0.822 |
DAPK1 |
0.716 | -0.067 | -3 | 0.807 |
HASPIN |
0.716 | -0.026 | -1 | 0.568 |
ASK1 |
0.716 | -0.056 | 1 | 0.764 |
ROCK1 |
0.716 | -0.008 | -3 | 0.786 |
TNNI3K_TYR |
0.716 | 0.001 | 1 | 0.794 |
TYRO3 |
0.716 | -0.121 | 3 | 0.826 |
EPHB4 |
0.715 | -0.092 | -1 | 0.818 |
TTK |
0.715 | -0.078 | -2 | 0.694 |
JAK3 |
0.714 | -0.072 | 1 | 0.787 |
ABL2 |
0.713 | -0.054 | -1 | 0.770 |
DDR1 |
0.712 | -0.116 | 4 | 0.730 |
ABL1 |
0.711 | -0.051 | -1 | 0.768 |
PDGFRB |
0.711 | -0.114 | 3 | 0.834 |
PDGFRA |
0.709 | -0.099 | 3 | 0.836 |
FLT3 |
0.709 | -0.096 | 3 | 0.820 |
FGR |
0.708 | -0.088 | 1 | 0.743 |
FGFR1 |
0.708 | -0.104 | 3 | 0.801 |
CK2A1 |
0.708 | -0.062 | 1 | 0.564 |
EPHA4 |
0.708 | -0.095 | 2 | 0.343 |
INSRR |
0.707 | -0.128 | 3 | 0.781 |
HCK |
0.707 | -0.061 | -1 | 0.817 |
KIT |
0.707 | -0.107 | 3 | 0.826 |
KDR |
0.706 | -0.102 | 3 | 0.786 |
WEE1_TYR |
0.706 | -0.051 | -1 | 0.714 |
ITK |
0.706 | -0.091 | -1 | 0.782 |
TNK1 |
0.706 | -0.087 | 3 | 0.801 |
TNK2 |
0.706 | -0.089 | 3 | 0.800 |
LCK |
0.706 | -0.033 | -1 | 0.821 |
YES1 |
0.705 | -0.090 | -1 | 0.830 |
EPHB1 |
0.705 | -0.118 | 1 | 0.738 |
ALPHAK3 |
0.705 | -0.082 | -1 | 0.715 |
FGFR2 |
0.705 | -0.153 | 3 | 0.822 |
LTK |
0.705 | -0.085 | 3 | 0.791 |
ALK |
0.704 | -0.093 | 3 | 0.774 |
TXK |
0.704 | -0.066 | 1 | 0.694 |
BIKE |
0.704 | -0.040 | 1 | 0.602 |
FER |
0.703 | -0.156 | 1 | 0.736 |
EPHB2 |
0.703 | -0.112 | -1 | 0.808 |
SRMS |
0.703 | -0.133 | 1 | 0.724 |
EPHB3 |
0.702 | -0.126 | -1 | 0.811 |
TEK |
0.702 | -0.143 | 3 | 0.777 |
BTK |
0.702 | -0.107 | -1 | 0.761 |
AXL |
0.701 | -0.137 | 3 | 0.803 |
STLK3 |
0.701 | -0.096 | 1 | 0.733 |
EPHA3 |
0.700 | -0.109 | 2 | 0.332 |
INSR |
0.699 | -0.109 | 3 | 0.752 |
NTRK2 |
0.699 | -0.113 | 3 | 0.785 |
MERTK |
0.698 | -0.132 | 3 | 0.801 |
PTK6 |
0.698 | -0.133 | -1 | 0.715 |
MET |
0.698 | -0.114 | 3 | 0.817 |
YANK2 |
0.698 | -0.047 | 2 | 0.221 |
BLK |
0.697 | -0.067 | -1 | 0.813 |
EPHA7 |
0.697 | -0.107 | 2 | 0.341 |
NTRK1 |
0.697 | -0.157 | -1 | 0.790 |
BMX |
0.697 | -0.091 | -1 | 0.714 |
TEC |
0.696 | -0.103 | -1 | 0.729 |
FLT4 |
0.696 | -0.137 | 3 | 0.776 |
FGFR3 |
0.696 | -0.144 | 3 | 0.795 |
FLT1 |
0.696 | -0.129 | -1 | 0.780 |
ERBB2 |
0.695 | -0.136 | 1 | 0.715 |
PTK2B |
0.695 | -0.075 | -1 | 0.763 |
FRK |
0.695 | -0.101 | -1 | 0.814 |
DDR2 |
0.694 | -0.081 | 3 | 0.782 |
EPHA1 |
0.694 | -0.124 | 3 | 0.797 |
CK1A |
0.693 | -0.056 | -3 | 0.440 |
FYN |
0.692 | -0.074 | -1 | 0.802 |
LYN |
0.692 | -0.088 | 3 | 0.742 |
AAK1 |
0.689 | -0.004 | 1 | 0.495 |
NTRK3 |
0.689 | -0.132 | -1 | 0.753 |
FGFR4 |
0.688 | -0.102 | -1 | 0.741 |
EPHA5 |
0.688 | -0.135 | 2 | 0.316 |
CSK |
0.688 | -0.127 | 2 | 0.350 |
EGFR |
0.687 | -0.103 | 1 | 0.627 |
EPHA8 |
0.687 | -0.118 | -1 | 0.781 |
PTK2 |
0.686 | -0.061 | -1 | 0.751 |
MATK |
0.685 | -0.131 | -1 | 0.689 |
SRC |
0.684 | -0.099 | -1 | 0.799 |
MUSK |
0.684 | -0.106 | 1 | 0.618 |
IGF1R |
0.678 | -0.140 | 3 | 0.698 |
EPHA2 |
0.677 | -0.127 | -1 | 0.755 |
CK1G3 |
0.677 | -0.054 | -3 | 0.398 |
SYK |
0.676 | -0.087 | -1 | 0.742 |
ERBB4 |
0.670 | -0.110 | 1 | 0.608 |
FES |
0.666 | -0.120 | -1 | 0.696 |
ZAP70 |
0.657 | -0.089 | -1 | 0.662 |
CK1G2 |
0.651 | -0.081 | -3 | 0.492 |