Motif 784 (n=166)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0A6YYG9 ARPC4-TTLL3 S43 ochoa Protein ARPC4-TTLL3 None
A0AVK6 E2F8 S102 ochoa Transcription factor E2F8 (E2F-8) Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}.
A4D2H0 CTAGE15 S138 ochoa cTAGE family member 15 (Protein cTAGE-15) None
A4FU28 CTAGE9 S138 ochoa cTAGE family member 9 (Protein cTAGE-9) None
A6H8Y1 BDP1 S1317 ochoa Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.
A6H8Y1 BDP1 S1623 ochoa Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.
O00186 STXBP3 S323 ochoa Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}.
O00533 CHL1 S1137 ochoa Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}.
O15027 SEC16A S561 psp Protein transport protein Sec16A (SEC16 homolog A) (p250) Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}.
O15265 ATXN7 S115 ochoa Ataxin-7 (Spinocerebellar ataxia type 7 protein) Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}.
O43148 RNMT S29 ochoa mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}.
O43432 EIF4G3 S1409 ochoa Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}.
O60218 AKR1B10 S163 ochoa Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}.
O60264 SMARCA5 S710 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}.
O60271 SPAG9 S949 ochoa C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
O75312 ZPR1 S375 ochoa Zinc finger protein ZPR1 (Zinc finger protein 259) Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766, ECO:0000269|PubMed:29851065}.
O75563 SKAP2 S223 ochoa Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}.
O75626 PRDM1 S272 ochoa PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.
O75694 NUP155 S914 ochoa Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.
O95243 MBD4 S319 ochoa Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}.
O95757 HSPA4L S508 ochoa Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}.
P02647 APOA1 S55 ochoa Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}.
P02775 PPBP S55 ochoa Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))] LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.
P09874 PARP1 S455 ochoa Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}.
P0CG41 CTAGE8 S138 ochoa cTAGE family member 8 (Protein cTAGE-8) None
P11137 MAP2 S1159 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P12882 MYH1 S1226 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 S1222 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S1224 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13631 RARG S176 ochoa Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}.
P15374 UCHL3 S128 ochoa Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:21762696, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:2530630, ECO:0000269|PubMed:9790970}.
P18583 SON S281 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P27816 MAP4 S71 ochoa Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
P28370 SMARCA1 S725 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.
P29536 LMOD1 S85 ochoa Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}.
P35221 CTNNA1 S295 ochoa Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}.
P42702 LIFR S534 ochoa Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
P49792 RANBP2 S1422 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2831 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50851 LRBA S1231 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
P51587 BRCA2 S445 ochoa Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P59998 ARPC4 S43 ochoa Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
P78527 PRKDC S3363 ochoa DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
Q00341 HDLBP S622 ochoa Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Q01538 MYT1 S108 ochoa Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}.
Q01968 OCRL S709 ochoa Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86) Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:10764818, PubMed:15474001, PubMed:7761412, PubMed:9430698). Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:25869668, PubMed:7761412). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:15474001, ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:22072788, ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:7761412, ECO:0000269|PubMed:9430698}.
Q03014 HHEX S213 ochoa Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein) Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). {ECO:0000250|UniProtKB:P43120, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:20028982, ECO:0000269|PubMed:8096636}.
Q03111 MLLT1 S359 ochoa Protein ENL (YEATS domain-containing protein 1) Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}.
Q08AD1 CAMSAP2 S901 ochoa Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.
Q0D2I5 IFFO1 S377 ochoa Non-homologous end joining factor IFFO1 (NHEJ factor IFFO1) (Intermediate filament family orphan 1) (Tumor antigen HOM-TES-103) Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). {ECO:0000269|PubMed:31548606}.
Q13077 TRAF1 S64 ochoa TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}.
Q13277 STX3 S207 ochoa Syntaxin-3 Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. {ECO:0000269|PubMed:24726755}.; FUNCTION: [Isoform B]: Essential for survival of retinal photoreceetors. {ECO:0000269|PubMed:33974130}.; FUNCTION: [Isoform 3]: Functions as a regulator of gene expression. {ECO:0000269|PubMed:29475951}.
Q13439 GOLGA4 S1514 ochoa Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.
Q13733 ATP1A4 S492 ochoa Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
Q14151 SAFB2 S207 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14207 NPAT S377 ochoa Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
Q14789 GOLGB1 S543 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q15047 SETDB1 S920 ochoa Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}.
Q15390 MTFR1 S288 ochoa Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}.
Q15468 STIL S395 ochoa|psp SCL-interrupting locus protein (TAL-1-interrupting locus protein) Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}.
Q16576 RBBP7 S314 psp Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
Q16891 IMMT S514 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q2M2Z5 KIZ S618 ochoa Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}.
Q2NKX8 ERCC6L S1004 ochoa DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}.
Q5SW79 CEP170 S122 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T4S7 UBR4 S1737 ochoa E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}.
Q5TCZ1 SH3PXD2A S186 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5UIP0 RIF1 S1613 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VZK9 CARMIL1 S1135 ochoa F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.
Q63HN8 RNF213 S3525 ochoa E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}.
Q6IQ55 TTBK2 S407 ochoa Tau-tubulin kinase 2 (EC 2.7.11.1) Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}.
Q6N043 ZNF280D S802 ochoa Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) May function as a transcription factor.
Q6P0Q8 MAST2 S1429 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6PJW8 CNST S175 ochoa Consortin Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}.
Q6PJW8 CNST S299 ochoa Consortin Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}.
Q6UB99 ANKRD11 S1307 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6ZSZ6 TSHZ1 S523 ochoa Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}.
Q71F23 CENPU S139 ochoa Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.
Q76FK4 NOL8 S508 ochoa Nucleolar protein 8 (Nucleolar protein Nop132) Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.
Q7L014 DDX46 S804 ochoa Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}.
Q7Z5K2 WAPL S1076 ochoa Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.
Q7Z699 SPRED1 Y292 ochoa Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}.
Q7Z6Z7 HUWE1 S3261 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86UF2 CTAGE6 S138 ochoa cTAGE family member 6 (Protein cTAGE-6) None
Q8IX12 CCAR1 S992 ochoa Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.
Q8IX94 CTAGE4 S138 ochoa cTAGE family member 4 (Protein cTAGE-4) Tumor-associated antigen.
Q8IYB7 DIS3L2 S139 ochoa DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.
Q8N3C0 ASCC3 S221 ochoa Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}.
Q8N3K9 CMYA5 S2479 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8N5B7 CERS5 S354 ochoa|psp Ceramide synthase 5 (CerS5) (LAG1 longevity assurance homolog 5) (Sphingoid base N-palmitoyltransferase CERS5) (EC 2.3.1.291) (Sphingosine N-acyltransferase CERS5) (EC 2.3.1.24) Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). {ECO:0000250|UniProtKB:Q9D6K9, ECO:0000269|PubMed:16951403, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}.
Q8N806 UBR7 S354 ochoa Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. {ECO:0000250}.
Q8NAA4 ATG16L2 S234 ochoa Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. {ECO:0000250|UniProtKB:Q6KAU8}.
Q8NEF9 SRFBP1 S145 ochoa Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.
Q8NEF9 SRFBP1 S279 ochoa Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.
Q8NEV8 EXPH5 S940 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NEV8 EXPH5 S1236 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8TAQ5 ZNF420 S68 psp Zinc finger protein 420 May be involved in transcriptional regulation.
Q92551 IP6K1 S143 ochoa Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Q92574 TSC1 S483 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q92930 RAB8B S180 ochoa Ras-related protein Rab-8B (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P70550, ECO:0000269|PubMed:32344433, ECO:0000305}.
Q92932 PTPRN2 S434 ochoa Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}.
Q92945 KHSRP S274 ochoa|psp Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.
Q96BD0 SLCO4A1 S361 ochoa Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}.
Q96BT3 CENPT S343 ochoa Centromere protein T (CENP-T) (Interphase centromere complex protein 22) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.
Q96DY7 MTBP S756 ochoa Mdm2-binding protein (hMTBP) Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.
Q96EY5 MVB12A S87 ochoa Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}.
Q96L93 KIF16B S1172 ochoa Kinesin-like protein KIF16B (Sorting nexin-23) Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}.
Q96NE9 FRMD6 S352 ochoa FERM domain-containing protein 6 (Willin) None
Q96PZ0 PUS7 S39 ochoa Pseudouridylate synthase 7 homolog (EC 5.4.99.-) Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}.
Q96ST3 SIN3A S1161 ochoa Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}.
Q96T58 SPEN S1005 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99590 SCAF11 S533 ochoa Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}.
Q9BSQ5 CCM2 S292 ochoa Cerebral cavernous malformations 2 protein (Malcavernin) Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BVJ6 UTP14A S78 ochoa U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) May be required for ribosome biogenesis. {ECO:0000250}.
Q9BW71 HIRIP3 S125 ochoa HIRA-interacting protein 3 Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}.
Q9BXP5 SRRT S718 ochoa Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}.
Q9H3M0 KCNF1 S178 ochoa Voltage-gated potassium channel regulatory subunit KCNF1 (Potassium voltage-gated channel subfamily F member 1) (Voltage-gated potassium channel subunit Kv5.1) (kH1) Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone. {ECO:0000250|UniProtKB:D4ADX7}.
Q9H3R0 KDM4C S487 ochoa Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.
Q9H6S3 EPS8L2 S693 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.
Q9H8E8 KAT14 S428 ochoa Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. {ECO:0000269|PubMed:19103755}.
Q9H9Q2 COPS7B S225 ochoa COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.
Q9NP62 GCM1 S178 psp Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}.
Q9NQ86 TRIM36 S462 ochoa E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}.
Q9NRA8 EIF4ENIF1 S414 ochoa Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.
Q9NSV4 DIAPH3 S1173 ochoa Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}.
Q9NY74 ETAA1 S342 ochoa Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}.
Q9NYF8 BCLAF1 S196 ochoa Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9NYI0 PSD3 S997 ochoa PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) Guanine nucleotide exchange factor for ARF6. {ECO:0000250}.
Q9P0V9 SEPTIN10 S432 ochoa Septin-10 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}.
Q9P0W2 HMG20B S161 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35) Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
Q9P291 ARMCX1 S44 ochoa Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1) Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. {ECO:0000250|UniProtKB:Q9CX83}.
Q9P2D1 CHD7 S2956 ochoa Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}.
Q9UJA5 TRMT6 S288 ochoa tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}.
Q9UJU2 LEF1 S42 ochoa|psp Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha) Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:P27782, ECO:0000269|PubMed:11266540, ECO:0000269|PubMed:19653274, ECO:0000269|PubMed:2010090}.; FUNCTION: [Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. {ECO:0000269|PubMed:19653274}.; FUNCTION: [Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. {ECO:0000269|PubMed:11326276}.; FUNCTION: [Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. {ECO:0000269|PubMed:19653274}.
Q9UKE5 TNIK S502 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9UKL3 CASP8AP2 S1380 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9UKL3 CASP8AP2 S1601 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9UKX2 MYH2 S1228 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 S1741 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9ULU8 CADPS S377 ochoa Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.
Q9UNP9 PPIE S91 ochoa Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:18258190, PubMed:20460131, PubMed:20677832, PubMed:8977107). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:18258190, PubMed:20460131, PubMed:8977107). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:18258190, PubMed:20541251, PubMed:20677832, PubMed:8977107). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20460131, PubMed:20541251, PubMed:20677832). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:18258190, ECO:0000269|PubMed:20460131, ECO:0000269|PubMed:20541251, ECO:0000269|PubMed:20677832, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:8977107}.
Q9UPZ3 HPS5 S712 ochoa BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.
Q9Y2J2 EPB41L3 S495 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y2J2 EPB41L3 S833 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y3B9 RRP15 S84 ochoa RRP15-like protein (Ribosomal RNA-processing protein 15) None
Q9Y4D1 DAAM1 S1027 ochoa Disheveled-associated activator of morphogenesis 1 Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.
Q9Y4G6 TLN2 S2172 ochoa Talin-2 As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}.
Q9Y6R1 SLC4A4 S219 ochoa Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.
Q9Y5L4 TIMM13 S57 Sugiyama Mitochondrial import inner membrane translocase subunit Tim13 Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.
O60763 USO1 S751 Sugiyama General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.
Q9ULV4 CORO1C S389 Sugiyama Coronin-1C (Coronin-3) (hCRNN4) Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}.
P13639 EEF2 S793 Sugiyama Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
O43293 DAPK3 S371 Sugiyama Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}.
O60285 NUAK1 S358 Sugiyama NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.
Q9Y3F4 STRAP S254 Sugiyama Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.
P09110 ACAA1 S206 Sugiyama 3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.16) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Acetyl-CoA acyltransferase) (EC 2.3.1.9) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase) Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:11734571, PubMed:2882519). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:11734571, PubMed:2882519). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:11734571, PubMed:2882519). {ECO:0000305|PubMed:11734571, ECO:0000305|PubMed:2882519}.
Q9NPI1 BRD7 S336 Sugiyama Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.
Q9BZC7 ABCA2 S1113 Sugiyama ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}.
Q15785 TOMM34 S219 Sugiyama Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}.
P34897 SHMT2 S417 Sugiyama Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}.
Q14980 NUMA1 S861 Sugiyama Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
P53609 PGGT1B S347 Sugiyama Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269|PubMed:8106351}.
P31949 S100A11 S35 Sugiyama Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}.
Q6XUX3 DSTYK S575 Sugiyama Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.
Q8IU85 CAMK1D S64 Sugiyama Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.
Q14980 NUMA1 S863 Sugiyama Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Download
reactome_id name p -log10_p
R-HSA-774815 Nucleosome assembly 0.000314 3.504
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.000314 3.504
R-HSA-6804754 Regulation of TP53 Expression 0.000913 3.040
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.001239 2.907
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 0.002737 2.563
R-HSA-9763198 Impaired BRCA2 binding to SEM1 (DSS1) 0.021502 1.668
R-HSA-9709275 Impaired BRCA2 translocation to the nucleus 0.021502 1.668
R-HSA-5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... 0.032080 1.494
R-HSA-8964011 HDL clearance 0.004460 2.351
R-HSA-5682113 Defective ABCA1 causes TGD 0.052896 1.277
R-HSA-8941237 Invadopodia formation 0.052896 1.277
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.073267 1.135
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 0.083288 1.079
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 0.093202 1.031
R-HSA-8951430 RUNX3 regulates WNT signaling 0.103009 0.987
R-HSA-447041 CHL1 interactions 0.103009 0.987
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.103009 0.987
R-HSA-2470946 Cohesin Loading onto Chromatin 0.103009 0.987
R-HSA-112126 ALKBH3 mediated reversal of alkylation damage 0.112710 0.948
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.131802 0.880
R-HSA-5358493 Synthesis of diphthamide-EEF2 0.150484 0.823
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.059036 1.229
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.061930 1.208
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.061930 1.208
R-HSA-1855170 IPs transport between nucleus and cytosol 0.067860 1.168
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.067860 1.168
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.070893 1.149
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.195461 0.709
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.077088 1.113
R-HSA-212300 PRC2 methylates histones and DNA 0.080247 1.096
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.089958 1.046
R-HSA-141424 Amplification of signal from the kinetochores 0.019968 1.700
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.019968 1.700
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.093269 1.030
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.229731 0.639
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.238069 0.623
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.238069 0.623
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.238069 0.623
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.238069 0.623
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.238069 0.623
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.124509 0.905
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.286247 0.543
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.169270 0.771
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.316670 0.499
R-HSA-72163 mRNA Splicing - Major Pathway 0.202727 0.693
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.256154 0.591
R-HSA-6798695 Neutrophil degranulation 0.078464 1.105
R-HSA-8964058 HDL remodeling 0.229731 0.639
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.228158 0.642
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.254477 0.594
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.262549 0.581
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.220196 0.657
R-HSA-5696398 Nucleotide Excision Repair 0.135771 0.867
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.055765 1.254
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.142804 0.845
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.264171 0.578
R-HSA-72172 mRNA Splicing 0.227640 0.643
R-HSA-8963901 Chylomicron remodeling 0.168768 0.773
R-HSA-8963896 HDL assembly 0.177762 0.750
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.109187 0.962
R-HSA-72086 mRNA Capping 0.316670 0.499
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.016598 1.780
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.293977 0.532
R-HSA-8963888 Chylomicron assembly 0.141194 0.850
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 0.064872 1.188
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.070893 1.149
R-HSA-3000471 Scavenging by Class B Receptors 0.204168 0.690
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.262549 0.581
R-HSA-525793 Myogenesis 0.047960 1.319
R-HSA-4641265 Repression of WNT target genes 0.159675 0.797
R-HSA-69618 Mitotic Spindle Checkpoint 0.033775 1.471
R-HSA-9842860 Regulation of endogenous retroelements 0.126045 0.899
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 0.052896 1.277
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.063136 1.200
R-HSA-69478 G2/M DNA replication checkpoint 0.093202 1.031
R-HSA-114516 Disinhibition of SNARE formation 0.103009 0.987
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.141194 0.850
R-HSA-192814 vRNA Synthesis 0.141194 0.850
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 0.150484 0.823
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.150484 0.823
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.159675 0.797
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.168768 0.773
R-HSA-1855191 Synthesis of IPs in the nucleus 0.177762 0.750
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.177762 0.750
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.083446 1.079
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.093269 1.030
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.113830 0.944
R-HSA-9764561 Regulation of CDH1 Function 0.157821 0.802
R-HSA-8949613 Cristae formation 0.301623 0.521
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.316670 0.499
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.204350 0.690
R-HSA-68877 Mitotic Prometaphase 0.029226 1.534
R-HSA-8963898 Plasma lipoprotein assembly 0.278433 0.555
R-HSA-156711 Polo-like kinase mediated events 0.026385 1.579
R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 0.159675 0.797
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.232889 0.633
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.168768 0.773
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.054088 1.267
R-HSA-427413 NoRC negatively regulates rRNA expression 0.055765 1.254
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.117362 0.930
R-HSA-199977 ER to Golgi Anterograde Transport 0.267255 0.573
R-HSA-9762292 Regulation of CDH11 function 0.131802 0.880
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.177762 0.750
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.070893 1.149
R-HSA-3214815 HDACs deacetylate histones 0.031996 1.495
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.115440 0.938
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.200409 0.698
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.015037 1.823
R-HSA-73942 DNA Damage Reversal 0.186659 0.729
R-HSA-2467813 Separation of Sister Chromatids 0.049667 1.304
R-HSA-204005 COPII-mediated vesicle transport 0.208300 0.681
R-HSA-8856828 Clathrin-mediated endocytosis 0.255605 0.592
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.093269 1.030
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.093269 1.030
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.126045 0.899
R-HSA-975634 Retinoid metabolism and transport 0.212258 0.673
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.133316 0.875
R-HSA-5619507 Activation of HOX genes during differentiation 0.133316 0.875
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 0.040222 1.396
R-HSA-9710421 Defective pyroptosis 0.106851 0.971
R-HSA-194441 Metabolism of non-coding RNA 0.165438 0.781
R-HSA-191859 snRNP Assembly 0.165438 0.781
R-HSA-168325 Viral Messenger RNA Synthesis 0.173118 0.762
R-HSA-9615710 Late endosomal microautophagy 0.316670 0.499
R-HSA-9609690 HCMV Early Events 0.207195 0.684
R-HSA-1483249 Inositol phosphate metabolism 0.011919 1.924
R-HSA-6806667 Metabolism of fat-soluble vitamins 0.252147 0.598
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.304203 0.517
R-HSA-180746 Nuclear import of Rev protein 0.073969 1.131
R-HSA-5693532 DNA Double-Strand Break Repair 0.039892 1.399
R-HSA-1369062 ABC transporters in lipid homeostasis 0.040222 1.396
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.293977 0.532
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.216224 0.665
R-HSA-9609646 HCMV Infection 0.172320 0.764
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.131802 0.880
R-HSA-425381 Bicarbonate transporters 0.141194 0.850
R-HSA-9796292 Formation of axial mesoderm 0.168768 0.773
R-HSA-177243 Interactions of Rev with host cellular proteins 0.093269 1.030
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.093269 1.030
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.096615 1.015
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.071945 1.143
R-HSA-68886 M Phase 0.074452 1.128
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.195461 0.709
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.047629 1.322
R-HSA-73894 DNA Repair 0.023938 1.621
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.009154 2.038
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.221169 0.655
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.290728 0.537
R-HSA-9827857 Specification of primordial germ cells 0.024311 1.614
R-HSA-9610379 HCMV Late Events 0.296623 0.528
R-HSA-199991 Membrane Trafficking 0.062404 1.205
R-HSA-5653656 Vesicle-mediated transport 0.119098 0.924
R-HSA-9764302 Regulation of CDH19 Expression and Function 0.083288 1.079
R-HSA-5336415 Uptake and function of diphtheria toxin 0.103009 0.987
R-HSA-6799990 Metal sequestration by antimicrobial proteins 0.131802 0.880
R-HSA-9005895 Pervasive developmental disorders 0.159675 0.797
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.159675 0.797
R-HSA-9697154 Disorders of Nervous System Development 0.159675 0.797
R-HSA-391160 Signal regulatory protein family interactions 0.177762 0.750
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.186659 0.729
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.086684 1.062
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.117362 0.930
R-HSA-9766229 Degradation of CDH1 0.128121 0.892
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.270534 0.568
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.270534 0.568
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.043957 1.357
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.293977 0.532
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.301623 0.521
R-HSA-8943724 Regulation of PTEN gene transcription 0.169270 0.771
R-HSA-5578749 Transcriptional regulation by small RNAs 0.216224 0.665
R-HSA-212165 Epigenetic regulation of gene expression 0.082063 1.086
R-HSA-397014 Muscle contraction 0.246227 0.609
R-HSA-9754189 Germ layer formation at gastrulation 0.229731 0.639
R-HSA-1474165 Reproduction 0.212712 0.672
R-HSA-6783589 Interleukin-6 family signaling 0.278433 0.555
R-HSA-3371556 Cellular response to heat stress 0.182386 0.739
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.168768 0.773
R-HSA-9675151 Disorders of Developmental Biology 0.204168 0.690
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.089958 1.046
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.103407 0.985
R-HSA-68882 Mitotic Anaphase 0.045209 1.345
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.293977 0.532
R-HSA-2980766 Nuclear Envelope Breakdown 0.157821 0.802
R-HSA-9659379 Sensory processing of sound 0.244138 0.612
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.045974 1.337
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.035356 1.452
R-HSA-9932451 SWI/SNF chromatin remodelers 0.286247 0.543
R-HSA-9932444 ATP-dependent chromatin remodelers 0.286247 0.543
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins 0.083288 1.079
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.103009 0.987
R-HSA-9635465 Suppression of apoptosis 0.141194 0.850
R-HSA-8854214 TBC/RABGAPs 0.106851 0.971
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.309188 0.510
R-HSA-6784531 tRNA processing in the nucleus 0.176980 0.752
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.316670 0.499
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.200409 0.698
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.096615 1.015
R-HSA-8964043 Plasma lipoprotein clearance 0.089958 1.046
R-HSA-3214841 PKMTs methylate histone lysines 0.015904 1.799
R-HSA-69278 Cell Cycle, Mitotic 0.108502 0.965
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.086732 1.062
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.246318 0.609
R-HSA-3214847 HATs acetylate histones 0.118925 0.925
R-HSA-1640170 Cell Cycle 0.055803 1.253
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.059676 1.224
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.059676 1.224
R-HSA-418990 Adherens junctions interactions 0.119187 0.924
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.103009 0.987
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.122308 0.913
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.195461 0.709
R-HSA-175474 Assembly Of The HIV Virion 0.254477 0.594
R-HSA-1169408 ISG15 antiviral mechanism 0.062718 1.203
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.154039 0.812
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.301623 0.521
R-HSA-8852135 Protein ubiquitination 0.228158 0.642
R-HSA-4839726 Chromatin organization 0.009674 2.014
R-HSA-421270 Cell-cell junction organization 0.174112 0.759
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.301623 0.521
R-HSA-3214842 HDMs demethylate histones 0.286247 0.543
R-HSA-5578775 Ion homeostasis 0.154039 0.812
R-HSA-68875 Mitotic Prophase 0.059497 1.226
R-HSA-936837 Ion transport by P-type ATPases 0.184743 0.733
R-HSA-3247509 Chromatin modifying enzymes 0.021840 1.661
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.161899 0.791
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.089958 1.046
R-HSA-8878171 Transcriptional regulation by RUNX1 0.279496 0.554
R-HSA-8876725 Protein methylation 0.186659 0.729
R-HSA-879518 Organic anion transport by SLCO transporters 0.270534 0.568
R-HSA-446728 Cell junction organization 0.224991 0.648
R-HSA-1500931 Cell-Cell communication 0.161032 0.793
R-HSA-73886 Chromosome Maintenance 0.016598 1.780
R-HSA-5633007 Regulation of TP53 Activity 0.013760 1.861
R-HSA-2559580 Oxidative Stress Induced Senescence 0.035688 1.447
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.232147 0.634
R-HSA-74160 Gene expression (Transcription) 0.249416 0.603
R-HSA-201556 Signaling by ALK 0.014218 1.847
R-HSA-73884 Base Excision Repair 0.292217 0.534
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.293977 0.532
R-HSA-162599 Late Phase of HIV Life Cycle 0.098107 1.008
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.296623 0.528
R-HSA-9671555 Signaling by PDGFR in disease 0.254477 0.594
R-HSA-69620 Cell Cycle Checkpoints 0.186855 0.728
R-HSA-3700989 Transcriptional Regulation by TP53 0.084853 1.071
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.131802 0.880
R-HSA-9008059 Interleukin-37 signaling 0.059036 1.229
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.054088 1.267
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.262549 0.581
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.293977 0.532
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.169270 0.771
R-HSA-73864 RNA Polymerase I Transcription 0.240137 0.620
R-HSA-162906 HIV Infection 0.281902 0.550
R-HSA-8953750 Transcriptional Regulation by E2F6 0.089958 1.046
R-HSA-162587 HIV Life Cycle 0.124578 0.905
R-HSA-449836 Other interleukin signaling 0.229731 0.639
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.293977 0.532
R-HSA-9679191 Potential therapeutics for SARS 0.037448 1.427
R-HSA-1834941 STING mediated induction of host immune responses 0.229731 0.639
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.192554 0.715
R-HSA-72306 tRNA processing 0.151704 0.819
R-HSA-2559583 Cellular Senescence 0.172336 0.764
R-HSA-9612973 Autophagy 0.293674 0.532
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.287784 0.541
R-HSA-9645723 Diseases of programmed cell death 0.284212 0.546
R-HSA-381038 XBP1(S) activates chaperone genes 0.276199 0.559
R-HSA-381119 Unfolded Protein Response (UPR) 0.241152 0.618
R-HSA-381070 IRE1alpha activates chaperones 0.300211 0.523
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.324072 0.489
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.324072 0.489
R-HSA-8863795 Downregulation of ERBB2 signaling 0.324072 0.489
R-HSA-6807878 COPI-mediated anterograde transport 0.324094 0.489
R-HSA-5619102 SLC transporter disorders 0.326178 0.487
R-HSA-8953854 Metabolism of RNA 0.328051 0.484
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.328056 0.484
R-HSA-5619115 Disorders of transmembrane transporters 0.330552 0.481
R-HSA-162588 Budding and maturation of HIV virion 0.331395 0.480
R-HSA-1538133 G0 and Early G1 0.338638 0.470
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.338638 0.470
R-HSA-382556 ABC-family proteins mediated transport 0.339904 0.469
R-HSA-70171 Glycolysis 0.339904 0.469
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.343923 0.464
R-HSA-9930044 Nuclear RNA decay 0.345804 0.461
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.345804 0.461
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.345804 0.461
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.345804 0.461
R-HSA-9733709 Cardiogenesis 0.345804 0.461
R-HSA-9022692 Regulation of MECP2 expression and activity 0.345804 0.461
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.345804 0.461
R-HSA-390522 Striated Muscle Contraction 0.352892 0.452
R-HSA-5693537 Resolution of D-Loop Structures 0.352892 0.452
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.359904 0.444
R-HSA-5696400 Dual Incision in GG-NER 0.359904 0.444
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.359904 0.444
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.359904 0.444
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.359904 0.444
R-HSA-168255 Influenza Infection 0.364578 0.438
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.366841 0.436
R-HSA-381042 PERK regulates gene expression 0.366841 0.436
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.366841 0.436
R-HSA-9734767 Developmental Cell Lineages 0.369826 0.432
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.371164 0.430
R-HSA-9700206 Signaling by ALK in cancer 0.371164 0.430
R-HSA-211000 Gene Silencing by RNA 0.371164 0.430
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.373702 0.427
R-HSA-74158 RNA Polymerase III Transcription 0.373702 0.427
R-HSA-9682385 FLT3 signaling in disease 0.373702 0.427
R-HSA-69205 G1/S-Specific Transcription 0.373702 0.427
R-HSA-1296072 Voltage gated Potassium channels 0.380490 0.420
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.380490 0.420
R-HSA-390247 Beta-oxidation of very long chain fatty acids 0.380490 0.420
R-HSA-196757 Metabolism of folate and pterines 0.380490 0.420
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.387204 0.412
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism 0.387204 0.412
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.387204 0.412
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.387204 0.412
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.400417 0.397
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.406917 0.390
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.406917 0.390
R-HSA-8853884 Transcriptional Regulation by VENTX 0.406917 0.390
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.406917 0.390
R-HSA-3000480 Scavenging by Class A Receptors 0.413347 0.384
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.413347 0.384
R-HSA-9007101 Rab regulation of trafficking 0.416896 0.380
R-HSA-70326 Glucose metabolism 0.416896 0.380
R-HSA-165159 MTOR signalling 0.419707 0.377
R-HSA-110329 Cleavage of the damaged pyrimidine 0.419707 0.377
R-HSA-73928 Depyrimidination 0.419707 0.377
R-HSA-5693538 Homology Directed Repair 0.420634 0.376
R-HSA-389948 Co-inhibition by PD-1 0.425736 0.371
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.425999 0.371
R-HSA-9637690 Response of Mtb to phagocytosis 0.425999 0.371
R-HSA-948021 Transport to the Golgi and subsequent modification 0.431466 0.365
R-HSA-3214858 RMTs methylate histone arginines 0.432223 0.364
R-HSA-3928662 EPHB-mediated forward signaling 0.432223 0.364
R-HSA-9679506 SARS-CoV Infections 0.436081 0.360
R-HSA-9824272 Somitogenesis 0.438380 0.358
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.438380 0.358
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.439138 0.357
R-HSA-162909 Host Interactions of HIV factors 0.442801 0.354
R-HSA-9675135 Diseases of DNA repair 0.444470 0.352
R-HSA-5357905 Regulation of TNFR1 signaling 0.444470 0.352
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.447940 0.349
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.450495 0.346
R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.450495 0.346
R-HSA-8963899 Plasma lipoprotein remodeling 0.456455 0.341
R-HSA-2262752 Cellular responses to stress 0.456605 0.340
R-HSA-114608 Platelet degranulation 0.457318 0.340
R-HSA-380108 Chemokine receptors bind chemokines 0.462351 0.335
R-HSA-5658442 Regulation of RAS by GAPs 0.468183 0.330
R-HSA-912446 Meiotic recombination 0.473952 0.324
R-HSA-9843745 Adipogenesis 0.475156 0.323
R-HSA-5576891 Cardiac conduction 0.475156 0.323
R-HSA-112382 Formation of RNA Pol II elongation complex 0.479659 0.319
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.479659 0.319
R-HSA-6794361 Neurexins and neuroligins 0.479659 0.319
R-HSA-5339562 Uptake and actions of bacterial toxins 0.479659 0.319
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.485304 0.314
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.485304 0.314
R-HSA-445355 Smooth Muscle Contraction 0.485304 0.314
R-HSA-8951664 Neddylation 0.487515 0.312
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.490888 0.309
R-HSA-3858494 Beta-catenin independent WNT signaling 0.496090 0.304
R-HSA-73857 RNA Polymerase II Transcription 0.500556 0.301
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.501877 0.299
R-HSA-75893 TNF signaling 0.501877 0.299
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.501877 0.299
R-HSA-5654736 Signaling by FGFR1 0.501877 0.299
R-HSA-6807070 PTEN Regulation 0.506358 0.296
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.507283 0.295
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.509750 0.293
R-HSA-9664417 Leishmania phagocytosis 0.509750 0.293
R-HSA-9664407 Parasite infection 0.509750 0.293
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.512630 0.290
R-HSA-6782135 Dual incision in TC-NER 0.512630 0.290
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.513128 0.290
R-HSA-1632852 Macroautophagy 0.513128 0.290
R-HSA-9033241 Peroxisomal protein import 0.517920 0.286
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.517920 0.286
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.519837 0.284
R-HSA-8873719 RAB geranylgeranylation 0.523152 0.281
R-HSA-5362517 Signaling by Retinoic Acid 0.523152 0.281
R-HSA-983189 Kinesins 0.523152 0.281
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.523152 0.281
R-HSA-1227986 Signaling by ERBB2 0.523152 0.281
R-HSA-9793380 Formation of paraxial mesoderm 0.528328 0.277
R-HSA-1268020 Mitochondrial protein import 0.533448 0.273
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.533448 0.273
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.533448 0.273
R-HSA-9707616 Heme signaling 0.533448 0.273
R-HSA-2187338 Visual phototransduction 0.536339 0.271
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.538513 0.269
R-HSA-69242 S Phase 0.539593 0.268
R-HSA-9856651 MITF-M-dependent gene expression 0.546054 0.263
R-HSA-446652 Interleukin-1 family signaling 0.552451 0.258
R-HSA-9609507 Protein localization 0.555626 0.255
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.558232 0.253
R-HSA-5693606 DNA Double Strand Break Response 0.558232 0.253
R-HSA-1989781 PPARA activates gene expression 0.561928 0.250
R-HSA-167172 Transcription of the HIV genome 0.563029 0.249
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.572469 0.242
R-HSA-69202 Cyclin E associated events during G1/S transition 0.572469 0.242
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.572469 0.242
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.577112 0.239
R-HSA-9006936 Signaling by TGFB family members 0.577405 0.239
R-HSA-388841 Regulation of T cell activation by CD28 family 0.578622 0.238
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.581706 0.235
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.581706 0.235
R-HSA-4086398 Ca2+ pathway 0.586249 0.232
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.586249 0.232
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.590744 0.229
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.595190 0.225
R-HSA-5689603 UCH proteinases 0.599589 0.222
R-HSA-383280 Nuclear Receptor transcription pathway 0.608243 0.216
R-HSA-4086400 PCP/CE pathway 0.608243 0.216
R-HSA-5619084 ABC transporter disorders 0.608243 0.216
R-HSA-9955298 SLC-mediated transport of organic anions 0.608243 0.216
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.616711 0.210
R-HSA-8953897 Cellular responses to stimuli 0.619419 0.208
R-HSA-977225 Amyloid fiber formation 0.620877 0.207
R-HSA-76002 Platelet activation, signaling and aggregation 0.621367 0.207
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.621429 0.207
R-HSA-9707564 Cytoprotection by HMOX1 0.629073 0.201
R-HSA-390918 Peroxisomal lipid metabolism 0.633105 0.199
R-HSA-1500620 Meiosis 0.637094 0.196
R-HSA-6794362 Protein-protein interactions at synapses 0.637094 0.196
R-HSA-6802957 Oncogenic MAPK signaling 0.637094 0.196
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.641039 0.193
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.644942 0.190
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.644942 0.190
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.644942 0.190
R-HSA-212436 Generic Transcription Pathway 0.646826 0.189
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.652621 0.185
R-HSA-156902 Peptide chain elongation 0.652621 0.185
R-HSA-69275 G2/M Transition 0.654054 0.184
R-HSA-453274 Mitotic G2-G2/M phases 0.659270 0.181
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.660135 0.180
R-HSA-983712 Ion channel transport 0.661854 0.179
R-HSA-8986944 Transcriptional Regulation by MECP2 0.663831 0.178
R-HSA-156842 Eukaryotic Translation Elongation 0.671104 0.173
R-HSA-2682334 EPH-Ephrin signaling 0.671104 0.173
R-HSA-9837999 Mitochondrial protein degradation 0.678221 0.169
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.681721 0.166
R-HSA-2168880 Scavenging of heme from plasma 0.685184 0.164
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.688609 0.162
R-HSA-1296071 Potassium Channels 0.688609 0.162
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.689257 0.162
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.690032 0.161
R-HSA-8878159 Transcriptional regulation by RUNX3 0.691998 0.160
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.695215 0.158
R-HSA-8957275 Post-translational protein phosphorylation 0.695349 0.158
R-HSA-190236 Signaling by FGFR 0.695349 0.158
R-HSA-9614085 FOXO-mediated transcription 0.698665 0.156
R-HSA-1483255 PI Metabolism 0.708397 0.150
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.714711 0.146
R-HSA-9730414 MITF-M-regulated melanocyte development 0.721479 0.142
R-HSA-6803157 Antimicrobial peptides 0.738635 0.132
R-HSA-597592 Post-translational protein modification 0.746694 0.127
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.747083 0.127
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.749839 0.125
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.752564 0.123
R-HSA-9705683 SARS-CoV-2-host interactions 0.752849 0.123
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.755260 0.122
R-HSA-373760 L1CAM interactions 0.757926 0.120
R-HSA-1592230 Mitochondrial biogenesis 0.760564 0.119
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.770833 0.113
R-HSA-109582 Hemostasis 0.776280 0.110
R-HSA-69206 G1/S Transition 0.783054 0.106
R-HSA-194138 Signaling by VEGF 0.783054 0.106
R-HSA-69481 G2/M Checkpoints 0.787759 0.104
R-HSA-196854 Metabolism of vitamins and cofactors 0.789692 0.103
R-HSA-8856688 Golgi-to-ER retrograde transport 0.801275 0.096
R-HSA-5688426 Deubiquitination 0.801709 0.096
R-HSA-168249 Innate Immune System 0.804047 0.095
R-HSA-9824446 Viral Infection Pathways 0.806583 0.093
R-HSA-9948299 Ribosome-associated quality control 0.815965 0.088
R-HSA-913531 Interferon Signaling 0.817338 0.088
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.833276 0.079
R-HSA-9758941 Gastrulation 0.838678 0.076
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.840440 0.075
R-HSA-9658195 Leishmania infection 0.840502 0.075
R-HSA-9824443 Parasitic Infection Pathways 0.840502 0.075
R-HSA-73887 Death Receptor Signaling 0.847299 0.072
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.847299 0.072
R-HSA-1257604 PIP3 activates AKT signaling 0.858435 0.066
R-HSA-109581 Apoptosis 0.860148 0.065
R-HSA-195721 Signaling by WNT 0.862031 0.064
R-HSA-446203 Asparagine N-linked glycosylation 0.862479 0.064
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.873323 0.059
R-HSA-5689880 Ub-specific processing proteases 0.877434 0.057
R-HSA-168256 Immune System 0.880624 0.055
R-HSA-1852241 Organelle biogenesis and maintenance 0.885960 0.053
R-HSA-201681 TCF dependent signaling in response to WNT 0.890204 0.051
R-HSA-375276 Peptide ligand-binding receptors 0.893770 0.049
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.896083 0.048
R-HSA-5617833 Cilium Assembly 0.898346 0.047
R-HSA-5663205 Infectious disease 0.898829 0.046
R-HSA-1280218 Adaptive Immune System 0.899249 0.046
R-HSA-162582 Signal Transduction 0.902364 0.045
R-HSA-9006925 Intracellular signaling by second messengers 0.906014 0.043
R-HSA-428157 Sphingolipid metabolism 0.909946 0.041
R-HSA-9694516 SARS-CoV-2 Infection 0.911674 0.040
R-HSA-5357801 Programmed Cell Death 0.914773 0.039
R-HSA-1266738 Developmental Biology 0.917546 0.037
R-HSA-382551 Transport of small molecules 0.923349 0.035
R-HSA-449147 Signaling by Interleukins 0.923466 0.035
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.935313 0.029
R-HSA-72312 rRNA processing 0.936726 0.028
R-HSA-9824439 Bacterial Infection Pathways 0.939477 0.027
R-HSA-425407 SLC-mediated transmembrane transport 0.943219 0.025
R-HSA-1280215 Cytokine Signaling in Immune system 0.956918 0.019
R-HSA-9711123 Cellular response to chemical stress 0.957497 0.019
R-HSA-72766 Translation 0.957706 0.019
R-HSA-5673001 RAF/MAP kinase cascade 0.966315 0.015
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.966812 0.015
R-HSA-1483257 Phospholipid metabolism 0.968482 0.014
R-HSA-5684996 MAPK1/MAPK3 signaling 0.968830 0.014
R-HSA-112316 Neuronal System 0.970630 0.013
R-HSA-392499 Metabolism of proteins 0.974849 0.011
R-HSA-1474244 Extracellular matrix organization 0.978862 0.009
R-HSA-5683057 MAPK family signaling cascades 0.982306 0.008
R-HSA-1643685 Disease 0.984931 0.007
R-HSA-9006931 Signaling by Nuclear Receptors 0.985192 0.006
R-HSA-422475 Axon guidance 0.985929 0.006
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.989633 0.005
R-HSA-9675108 Nervous system development 0.990185 0.004
R-HSA-418594 G alpha (i) signalling events 0.991033 0.004
R-HSA-8978868 Fatty acid metabolism 0.991033 0.004
R-HSA-500792 GPCR ligand binding 0.998838 0.001
R-HSA-556833 Metabolism of lipids 0.999311 0.000
R-HSA-9709957 Sensory Perception 0.999566 0.000
R-HSA-388396 GPCR downstream signalling 0.999858 0.000
R-HSA-372790 Signaling by GPCR 0.999945 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.851 0.127 2 0.855
CDC7CDC7 0.847 0.073 1 0.846
DSTYKDSTYK 0.845 0.166 2 0.855
BMPR1BBMPR1B 0.843 0.373 1 0.754
MOSMOS 0.843 0.121 1 0.854
IKKBIKKB 0.842 0.022 -2 0.702
TGFBR2TGFBR2 0.841 0.222 -2 0.900
TGFBR1TGFBR1 0.841 0.389 -2 0.910
GCN2GCN2 0.841 -0.006 2 0.795
RAF1RAF1 0.839 0.009 1 0.823
BMPR2BMPR2 0.838 0.159 -2 0.859
ALK2ALK2 0.838 0.423 -2 0.904
CLK3CLK3 0.838 0.131 1 0.787
TBK1TBK1 0.838 -0.006 1 0.738
GRK6GRK6 0.837 0.160 1 0.792
CAMK2GCAMK2G 0.837 0.030 2 0.802
BMPR1ABMPR1A 0.836 0.400 1 0.757
ACVR2AACVR2A 0.836 0.325 -2 0.897
PRPKPRPK 0.836 -0.125 -1 0.827
IKKEIKKE 0.836 -0.007 1 0.739
ATMATM 0.836 0.125 1 0.775
NEK7NEK7 0.835 0.039 -3 0.844
ALK4ALK4 0.835 0.357 -2 0.913
NEK6NEK6 0.835 0.058 -2 0.860
ACVR2BACVR2B 0.835 0.326 -2 0.900
IKKAIKKA 0.835 0.083 -2 0.715
PLK1PLK1 0.834 0.209 -2 0.879
PDHK4PDHK4 0.833 -0.206 1 0.818
ATRATR 0.832 0.011 1 0.811
CAMK1BCAMK1B 0.832 -0.022 -3 0.838
FAM20CFAM20C 0.831 0.095 2 0.571
GRK4GRK4 0.831 0.050 -2 0.787
MTORMTOR 0.830 -0.111 1 0.741
PDHK1PDHK1 0.830 -0.142 1 0.819
PIM3PIM3 0.829 -0.021 -3 0.803
GRK5GRK5 0.829 -0.034 -3 0.860
ULK2ULK2 0.829 -0.127 2 0.792
KISKIS 0.828 0.038 1 0.643
PLK3PLK3 0.828 0.169 2 0.776
GRK1GRK1 0.827 0.070 -2 0.708
GRK7GRK7 0.826 0.193 1 0.715
PRKD1PRKD1 0.826 0.006 -3 0.778
NDR2NDR2 0.826 -0.062 -3 0.799
NLKNLK 0.826 -0.072 1 0.775
CAMK2BCAMK2B 0.824 0.090 2 0.761
PKN3PKN3 0.824 -0.029 -3 0.787
CDKL1CDKL1 0.824 -0.045 -3 0.772
MLK1MLK1 0.823 -0.078 2 0.804
TSSK2TSSK2 0.823 0.046 -5 0.868
NUAK2NUAK2 0.823 -0.023 -3 0.805
MARK4MARK4 0.823 -0.018 4 0.877
ULK1ULK1 0.823 -0.116 -3 0.805
NIKNIK 0.823 -0.101 -3 0.859
HUNKHUNK 0.822 -0.063 2 0.807
PRKD2PRKD2 0.822 0.012 -3 0.715
AMPKA1AMPKA1 0.821 -0.016 -3 0.811
LATS2LATS2 0.821 -0.024 -5 0.720
CK2A2CK2A2 0.821 0.294 1 0.705
TLK2TLK2 0.821 0.159 1 0.789
ERK5ERK5 0.821 -0.083 1 0.700
BCKDKBCKDK 0.820 -0.132 -1 0.812
PIM1PIM1 0.820 0.017 -3 0.740
ANKRD3ANKRD3 0.819 -0.063 1 0.807
TSSK1TSSK1 0.819 0.024 -3 0.827
CAMLCKCAMLCK 0.819 -0.091 -2 0.722
RIPK3RIPK3 0.819 -0.144 3 0.694
CAMK2DCAMK2D 0.819 -0.055 -3 0.804
DAPK2DAPK2 0.819 -0.093 -3 0.844
WNK3WNK3 0.818 -0.202 1 0.783
MAPKAPK2MAPKAPK2 0.818 0.029 -3 0.682
RSK2RSK2 0.818 -0.029 -3 0.738
TLK1TLK1 0.818 0.160 -2 0.862
DLKDLK 0.817 -0.107 1 0.781
NEK9NEK9 0.817 -0.134 2 0.820
MAPKAPK3MAPKAPK3 0.816 -0.046 -3 0.728
CHK1CHK1 0.816 0.059 -3 0.775
LATS1LATS1 0.816 0.043 -3 0.824
WNK1WNK1 0.815 -0.134 -2 0.710
MST4MST4 0.815 -0.079 2 0.830
NUAK1NUAK1 0.815 -0.014 -3 0.749
DNAPKDNAPK 0.815 0.070 1 0.736
NDR1NDR1 0.815 -0.111 -3 0.796
CAMK2ACAMK2A 0.815 0.041 2 0.780
AMPKA2AMPKA2 0.814 -0.028 -3 0.776
P90RSKP90RSK 0.814 -0.060 -3 0.740
CHAK2CHAK2 0.814 -0.118 -1 0.820
MASTLMASTL 0.814 -0.276 -2 0.740
CAMK4CAMK4 0.813 -0.091 -3 0.784
SRPK1SRPK1 0.813 -0.020 -3 0.720
SRPK2SRPK2 0.812 0.004 -3 0.641
CDK8CDK8 0.812 -0.032 1 0.633
P70S6KBP70S6KB 0.812 -0.064 -3 0.763
TTBK2TTBK2 0.812 -0.129 2 0.687
MEK1MEK1 0.812 -0.080 2 0.823
SKMLCKSKMLCK 0.812 -0.116 -2 0.696
HIPK4HIPK4 0.811 -0.080 1 0.724
CDKL5CDKL5 0.811 -0.083 -3 0.759
PKN2PKN2 0.811 -0.103 -3 0.807
ICKICK 0.810 -0.084 -3 0.805
YSK4YSK4 0.810 -0.067 1 0.752
PERKPERK 0.810 0.037 -2 0.863
SMG1SMG1 0.810 -0.026 1 0.769
PRKD3PRKD3 0.810 -0.020 -3 0.710
PKCDPKCD 0.809 -0.076 2 0.786
GRK2GRK2 0.809 0.000 -2 0.699
MARK2MARK2 0.809 0.016 4 0.810
PKRPKR 0.809 -0.073 1 0.777
HRIHRI 0.809 -0.006 -2 0.860
RSK3RSK3 0.809 -0.083 -3 0.732
NIM1NIM1 0.809 -0.131 3 0.726
QSKQSK 0.809 -0.027 4 0.858
BRAFBRAF 0.808 0.014 -4 0.775
SIKSIK 0.808 -0.025 -3 0.728
CK2A1CK2A1 0.808 0.245 1 0.678
SRPK3SRPK3 0.808 -0.015 -3 0.698
PLK4PLK4 0.807 -0.035 2 0.672
CLK4CLK4 0.807 0.007 -3 0.738
CDK1CDK1 0.807 0.026 1 0.575
MARK3MARK3 0.806 0.014 4 0.831
RIPK1RIPK1 0.806 -0.266 1 0.740
PKACGPKACG 0.806 -0.105 -2 0.605
QIKQIK 0.806 -0.118 -3 0.809
CDK2CDK2 0.806 0.008 1 0.645
MSK2MSK2 0.806 -0.083 -3 0.705
IRE2IRE2 0.805 -0.100 2 0.775
JNK2JNK2 0.805 0.033 1 0.578
MELKMELK 0.805 -0.087 -3 0.765
CLK1CLK1 0.805 0.015 -3 0.713
MLK4MLK4 0.804 -0.060 2 0.718
PLK2PLK2 0.804 0.133 -3 0.806
JNK3JNK3 0.804 0.022 1 0.610
MLK2MLK2 0.804 -0.237 2 0.800
MLK3MLK3 0.804 -0.098 2 0.735
CDK19CDK19 0.804 -0.042 1 0.593
BRSK1BRSK1 0.803 -0.063 -3 0.753
VRK2VRK2 0.803 -0.287 1 0.807
MSK1MSK1 0.802 -0.051 -3 0.709
NEK2NEK2 0.802 -0.145 2 0.793
RSK4RSK4 0.802 -0.024 -3 0.701
MARK1MARK1 0.802 -0.026 4 0.849
PHKG1PHKG1 0.802 -0.100 -3 0.788
IRE1IRE1 0.802 -0.192 1 0.714
MEKK3MEKK3 0.801 -0.094 1 0.746
AURCAURC 0.801 -0.074 -2 0.510
DYRK2DYRK2 0.800 -0.039 1 0.616
CDK5CDK5 0.800 -0.017 1 0.649
AURBAURB 0.800 -0.074 -2 0.516
BRSK2BRSK2 0.800 -0.099 -3 0.775
AURAAURA 0.800 -0.057 -2 0.499
PINK1PINK1 0.800 -0.090 1 0.783
MYLK4MYLK4 0.799 -0.082 -2 0.613
MEKK1MEKK1 0.799 -0.133 1 0.775
P38AP38A 0.799 -0.025 1 0.630
DCAMKL1DCAMKL1 0.799 -0.021 -3 0.744
CLK2CLK2 0.798 0.065 -3 0.717
NEK5NEK5 0.798 -0.071 1 0.777
GRK3GRK3 0.798 0.015 -2 0.665
CAMK1GCAMK1G 0.798 -0.055 -3 0.727
PAK1PAK1 0.798 -0.129 -2 0.620
CDK13CDK13 0.798 -0.056 1 0.606
P38BP38B 0.798 0.000 1 0.560
DRAK1DRAK1 0.798 -0.077 1 0.705
CDK7CDK7 0.798 -0.077 1 0.637
PRP4PRP4 0.797 -0.034 -3 0.740
MNK2MNK2 0.796 -0.132 -2 0.647
P38GP38G 0.796 0.007 1 0.494
ERK2ERK2 0.796 -0.036 1 0.599
PAK3PAK3 0.796 -0.181 -2 0.624
SSTKSSTK 0.796 -0.022 4 0.851
DCAMKL2DCAMKL2 0.796 -0.029 -3 0.774
ERK1ERK1 0.795 -0.022 1 0.561
CDK3CDK3 0.795 0.044 1 0.522
PAK2PAK2 0.795 -0.148 -2 0.615
ZAKZAK 0.795 -0.145 1 0.741
P38DP38D 0.794 0.029 1 0.537
SNRKSNRK 0.794 -0.204 2 0.719
CHAK1CHAK1 0.794 -0.208 2 0.756
PAK6PAK6 0.794 -0.092 -2 0.554
MEKK2MEKK2 0.794 -0.124 2 0.796
PKACBPKACB 0.794 -0.057 -2 0.534
MAPKAPK5MAPKAPK5 0.794 -0.144 -3 0.680
MEK5MEK5 0.793 -0.264 2 0.820
CAMK1DCAMK1D 0.793 -0.007 -3 0.639
MST2MST2 0.793 0.025 1 0.777
CDK18CDK18 0.793 -0.033 1 0.554
CK1ECK1E 0.792 -0.046 -3 0.576
NEK8NEK8 0.792 -0.095 2 0.816
GAKGAK 0.792 0.024 1 0.783
PRKXPRKX 0.792 -0.018 -3 0.636
TTBK1TTBK1 0.792 -0.129 2 0.618
CDK17CDK17 0.791 -0.028 1 0.503
PIM2PIM2 0.791 -0.064 -3 0.709
PKCAPKCA 0.791 -0.130 2 0.728
PASKPASK 0.791 -0.025 -3 0.822
CAMKK1CAMKK1 0.791 -0.115 -2 0.702
PKCBPKCB 0.791 -0.127 2 0.733
SGK3SGK3 0.791 -0.084 -3 0.720
WNK4WNK4 0.791 -0.180 -2 0.714
PKCGPKCG 0.790 -0.144 2 0.735
PKCHPKCH 0.790 -0.142 2 0.732
TAK1TAK1 0.790 0.025 1 0.839
PKG2PKG2 0.790 -0.106 -2 0.533
DYRK1ADYRK1A 0.790 -0.054 1 0.684
MNK1MNK1 0.789 -0.127 -2 0.665
SMMLCKSMMLCK 0.789 -0.106 -3 0.788
AKT2AKT2 0.788 -0.068 -3 0.652
CDK12CDK12 0.788 -0.064 1 0.578
TAO3TAO3 0.788 -0.096 1 0.757
PHKG2PHKG2 0.787 -0.117 -3 0.767
GSK3BGSK3B 0.787 -0.037 4 0.422
PKCZPKCZ 0.787 -0.192 2 0.769
CK1DCK1D 0.787 -0.032 -3 0.528
GSK3AGSK3A 0.787 0.001 4 0.432
DYRK4DYRK4 0.786 -0.004 1 0.558
CK1G1CK1G1 0.786 -0.065 -3 0.587
EEF2KEEF2K 0.785 -0.007 3 0.786
P70S6KP70S6K 0.785 -0.085 -3 0.671
CDK9CDK9 0.784 -0.093 1 0.608
IRAK4IRAK4 0.784 -0.226 1 0.731
NEK11NEK11 0.783 -0.208 1 0.760
IRAK1IRAK1 0.783 -0.249 -1 0.769
HIPK1HIPK1 0.783 -0.066 1 0.634
MST3MST3 0.783 -0.147 2 0.817
DAPK3DAPK3 0.782 -0.057 -3 0.766
CAMKK2CAMKK2 0.782 -0.158 -2 0.684
JNK1JNK1 0.782 0.001 1 0.564
TAO2TAO2 0.782 -0.149 2 0.836
PKACAPKACA 0.782 -0.066 -2 0.480
GCKGCK 0.781 -0.072 1 0.771
CDK14CDK14 0.781 -0.056 1 0.597
MST1MST1 0.781 -0.027 1 0.756
HIPK2HIPK2 0.781 -0.046 1 0.541
TTKTTK 0.780 0.128 -2 0.874
CAMK1ACAMK1A 0.780 -0.020 -3 0.614
NEK4NEK4 0.780 -0.163 1 0.753
CDK16CDK16 0.780 -0.022 1 0.524
CK1A2CK1A2 0.780 -0.050 -3 0.525
DYRK1BDYRK1B 0.779 -0.052 1 0.579
LKB1LKB1 0.779 -0.173 -3 0.808
AKT1AKT1 0.779 -0.079 -3 0.667
CHK2CHK2 0.779 -0.038 -3 0.598
PDK1PDK1 0.779 -0.149 1 0.765
MPSK1MPSK1 0.778 -0.144 1 0.739
DYRK3DYRK3 0.777 -0.071 1 0.631
TNIKTNIK 0.776 -0.079 3 0.803
MINKMINK 0.776 -0.122 1 0.768
RIPK2RIPK2 0.776 -0.205 1 0.720
HIPK3HIPK3 0.776 -0.110 1 0.640
DAPK1DAPK1 0.776 -0.070 -3 0.749
PKCTPKCT 0.776 -0.165 2 0.740
PDHK3_TYRPDHK3_TYR 0.776 0.146 4 0.877
HGKHGK 0.775 -0.136 3 0.792
NEK1NEK1 0.774 -0.145 1 0.745
MRCKAMRCKA 0.774 -0.057 -3 0.716
PAK5PAK5 0.774 -0.133 -2 0.501
MEK2MEK2 0.773 -0.193 2 0.803
ERK7ERK7 0.773 -0.064 2 0.502
SBKSBK 0.772 -0.021 -3 0.527
LRRK2LRRK2 0.772 -0.237 2 0.836
CDK6CDK6 0.772 -0.046 1 0.584
PKCIPKCI 0.771 -0.168 2 0.739
PDHK4_TYRPDHK4_TYR 0.771 0.131 2 0.876
CDK10CDK10 0.771 -0.058 1 0.582
HPK1HPK1 0.771 -0.121 1 0.754
VRK1VRK1 0.770 -0.231 2 0.843
PAK4PAK4 0.770 -0.131 -2 0.506
PKN1PKN1 0.769 -0.106 -3 0.688
SLKSLK 0.769 -0.120 -2 0.646
LOKLOK 0.769 -0.158 -2 0.677
MRCKBMRCKB 0.769 -0.069 -3 0.699
MAP3K15MAP3K15 0.769 -0.237 1 0.731
ALPHAK3ALPHAK3 0.769 0.032 -1 0.762
MEKK6MEKK6 0.768 -0.260 1 0.741
CDK4CDK4 0.768 -0.056 1 0.569
SGK1SGK1 0.768 -0.051 -3 0.569
MAP2K6_TYRMAP2K6_TYR 0.768 0.103 -1 0.860
BUB1BUB1 0.768 -0.012 -5 0.855
MAP2K4_TYRMAP2K4_TYR 0.768 0.026 -1 0.859
PDHK1_TYRPDHK1_TYR 0.767 0.096 -1 0.886
ROCK2ROCK2 0.767 -0.073 -3 0.747
KHS2KHS2 0.766 -0.069 1 0.771
PKCEPKCE 0.766 -0.119 2 0.722
OSR1OSR1 0.766 -0.050 2 0.779
KHS1KHS1 0.765 -0.108 1 0.759
NEK3NEK3 0.762 -0.206 1 0.720
MAP2K7_TYRMAP2K7_TYR 0.762 -0.132 2 0.858
STK33STK33 0.762 -0.207 2 0.621
BMPR2_TYRBMPR2_TYR 0.762 0.006 -1 0.857
TESK1_TYRTESK1_TYR 0.762 -0.145 3 0.827
YSK1YSK1 0.762 -0.194 2 0.794
BIKEBIKE 0.762 -0.011 1 0.663
AKT3AKT3 0.761 -0.083 -3 0.583
PBKPBK 0.761 -0.113 1 0.711
PINK1_TYRPINK1_TYR 0.759 -0.116 1 0.784
EPHA6EPHA6 0.758 0.032 -1 0.880
TXKTXK 0.758 0.126 1 0.780
DMPK1DMPK1 0.758 -0.063 -3 0.723
MAKMAK 0.757 -0.055 -2 0.581
PKG1PKG1 0.756 -0.122 -2 0.456
EPHB4EPHB4 0.756 0.009 -1 0.868
CRIKCRIK 0.756 -0.044 -3 0.656
PKMYT1_TYRPKMYT1_TYR 0.756 -0.213 3 0.785
EPHA4EPHA4 0.755 0.064 2 0.773
FERFER 0.755 0.011 1 0.826
ROCK1ROCK1 0.754 -0.086 -3 0.713
RETRET 0.753 -0.112 1 0.754
MOKMOK 0.753 -0.091 1 0.614
SRMSSRMS 0.753 0.045 1 0.800
ASK1ASK1 0.752 -0.205 1 0.726
YES1YES1 0.752 0.014 -1 0.842
BLKBLK 0.752 0.114 -1 0.851
EPHB2EPHB2 0.752 0.065 -1 0.860
TYK2TYK2 0.752 -0.142 1 0.762
CSF1RCSF1R 0.751 -0.048 3 0.716
TYRO3TYRO3 0.751 -0.116 3 0.725
EPHB1EPHB1 0.751 0.021 1 0.789
HCKHCK 0.751 0.007 -1 0.835
STLK3STLK3 0.750 -0.136 1 0.719
INSRRINSRR 0.750 -0.011 3 0.684
EPHB3EPHB3 0.750 0.029 -1 0.862
FGRFGR 0.750 -0.048 1 0.770
JAK2JAK2 0.750 -0.126 1 0.760
MST1RMST1R 0.750 -0.154 3 0.735
LIMK2_TYRLIMK2_TYR 0.749 -0.195 -3 0.864
MYO3AMYO3A 0.749 -0.150 1 0.731
ABL2ABL2 0.749 -0.015 -1 0.827
ROS1ROS1 0.749 -0.130 3 0.695
JAK3JAK3 0.748 -0.065 1 0.740
LCKLCK 0.748 0.042 -1 0.833
TAO1TAO1 0.748 -0.173 1 0.700
CK1ACK1A 0.748 -0.070 -3 0.444
LIMK1_TYRLIMK1_TYR 0.747 -0.263 2 0.846
YANK3YANK3 0.747 -0.099 2 0.398
MYO3BMYO3B 0.746 -0.187 2 0.806
ITKITK 0.745 -0.009 -1 0.814
DDR1DDR1 0.745 -0.173 4 0.807
KITKIT 0.745 -0.051 3 0.718
FGFR2FGFR2 0.744 -0.074 3 0.734
ABL1ABL1 0.744 -0.053 -1 0.821
HASPINHASPIN 0.744 -0.106 -1 0.684
NEK10_TYRNEK10_TYR 0.744 -0.084 1 0.687
TECTEC 0.744 0.026 -1 0.764
FYNFYN 0.744 0.077 -1 0.797
AAK1AAK1 0.743 0.015 1 0.560
MERTKMERTK 0.743 -0.034 3 0.709
FLT3FLT3 0.743 -0.085 3 0.713
TEKTEK 0.742 -0.086 3 0.667
FRKFRK 0.742 0.035 -1 0.870
EPHA5EPHA5 0.742 0.058 2 0.767
EPHA7EPHA7 0.740 -0.012 2 0.775
FGFR1FGFR1 0.740 -0.111 3 0.700
TNK2TNK2 0.740 -0.122 3 0.681
FLT1FLT1 0.739 -0.017 -1 0.857
BMXBMX 0.739 -0.017 -1 0.723
KDRKDR 0.739 -0.096 3 0.691
AXLAXL 0.739 -0.116 3 0.711
PDGFRBPDGFRB 0.739 -0.174 3 0.726
LYNLYN 0.739 0.003 3 0.643
BTKBTK 0.739 -0.097 -1 0.782
PTK6PTK6 0.738 -0.099 -1 0.735
EPHA3EPHA3 0.738 -0.066 2 0.756
FGFR3FGFR3 0.738 -0.048 3 0.711
CK1G3CK1G3 0.737 -0.041 -3 0.400
METMET 0.737 -0.082 3 0.711
NTRK1NTRK1 0.736 -0.114 -1 0.818
ERBB2ERBB2 0.736 -0.084 1 0.713
JAK1JAK1 0.736 -0.120 1 0.712
EPHA8EPHA8 0.734 0.007 -1 0.842
SYKSYK 0.734 0.074 -1 0.783
EGFREGFR 0.734 -0.007 1 0.620
TNNI3K_TYRTNNI3K_TYR 0.733 -0.145 1 0.743
PDGFRAPDGFRA 0.733 -0.226 3 0.722
PTK2BPTK2B 0.733 -0.036 -1 0.795
FLT4FLT4 0.732 -0.105 3 0.684
SRCSRC 0.732 -0.007 -1 0.805
NTRK2NTRK2 0.732 -0.138 3 0.684
ALKALK 0.732 -0.150 3 0.641
EPHA1EPHA1 0.731 -0.105 3 0.686
PTK2PTK2 0.731 0.038 -1 0.792
LTKLTK 0.730 -0.148 3 0.664
TNK1TNK1 0.729 -0.223 3 0.703
FGFR4FGFR4 0.729 -0.023 -1 0.789
NTRK3NTRK3 0.729 -0.101 -1 0.766
INSRINSR 0.729 -0.135 3 0.660
WEE1_TYRWEE1_TYR 0.729 -0.156 -1 0.735
EPHA2EPHA2 0.729 0.012 -1 0.810
MATKMATK 0.728 -0.086 -1 0.755
CSKCSK 0.726 -0.093 2 0.777
ERBB4ERBB4 0.721 -0.018 1 0.634
IGF1RIGF1R 0.720 -0.075 3 0.607
DDR2DDR2 0.720 -0.138 3 0.674
CK1G2CK1G2 0.718 -0.040 -3 0.498
YANK2YANK2 0.714 -0.115 2 0.406
MUSKMUSK 0.713 -0.143 1 0.596
FESFES 0.706 -0.119 -1 0.702
ZAP70ZAP70 0.699 -0.045 -1 0.678