Motif 783 (n=230)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYG9 | ARPC4-TTLL3 | S43 | ochoa | Protein ARPC4-TTLL3 | None |
| A0A0B4J1R7 | BORCS7-ASMT | S45 | ochoa | BLOC-1-related complex subunit 7 | None |
| A6NDB9 | PALM3 | S439 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| B2RTY4 | MYO9A | S1349 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O00559 | EBAG9 | S86 | ochoa | Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein) | May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241, ECO:0000269|PubMed:12672804}. |
| O14936 | CASK | S55 | ochoa | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O14936 | CASK | S151 | psp | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (PubMed:18423203). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:18423203}. |
| O15061 | SYNM | S699 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15061 | SYNM | S897 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15063 | GARRE1 | S574 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O15381 | NVL | S191 | ochoa | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| O43164 | PJA2 | S457 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43306 | ADCY6 | S576 | ochoa | Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) | Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17110384, PubMed:17916776). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity). {ECO:0000250|UniProtKB:Q01341, ECO:0000250|UniProtKB:Q03343, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:17916776}. |
| O43493 | TGOLN2 | S351 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43597 | SPRY2 | S167 | psp | Protein sprouty homolog 2 (Spry-2) | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}. |
| O43683 | BUB1 | S307 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43719 | HTATSF1 | S713 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60343 | TBC1D4 | S570 | ochoa|psp | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60841 | EIF5B | S460 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75121 | MFAP3L | S349 | ochoa | Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) | May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}. |
| O75151 | PHF2 | S879 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75410 | TACC1 | S153 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75665 | OFD1 | S827 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75676 | RPS6KA4 | S721 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O75717 | WDHD1 | S1090 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O76094 | SRP72 | S81 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O95232 | LUC7L3 | S395 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| O95793 | STAU1 | S278 | ochoa | Double-stranded RNA-binding protein Staufen homolog 1 | Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; FUNCTION: (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. {ECO:0000269|PubMed:10325410, ECO:0000269|PubMed:18498651, ECO:0000269|PubMed:23926355, ECO:0000269|PubMed:30301857}. |
| P06400 | RB1 | S882 | ochoa|psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P07942 | LAMB1 | S1682 | ochoa | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P11940 | PABPC1 | S237 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P12532 | CKMT1A | S147 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P13521 | SCG2 | S556 | ochoa | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
| P13591 | NCAM1 | S784 | ochoa | Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) | This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; FUNCTION: (Microbial infection) Acts as a receptor for rabies virus. {ECO:0000269|PubMed:9696812}.; FUNCTION: (Microbial infection) Acts as a receptor for Zika virus. {ECO:0000269|PubMed:32753727}. |
| P17540 | CKMT2 | S148 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P20807 | CAPN3 | S621 | ochoa | Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) | Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:27657329}. |
| P21817 | RYR1 | S2950 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P23025 | XPA | S196 | ochoa|psp | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769). {ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:31253769}. |
| P26358 | DNMT1 | S398 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27816 | MAP4 | S941 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29374 | ARID4A | S864 | ochoa|psp | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P31629 | HIVEP2 | S1447 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P34910 | EVI2B | S294 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35573 | AGL | S672 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P35749 | MYH11 | S1189 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38398 | BRCA1 | S451 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38398 | BRCA1 | S1460 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P46100 | ATRX | S25 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S890 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S1939 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S1973 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49790 | NUP153 | S390 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51608 | MECP2 | S313 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P55265 | ADAR | S629 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P59998 | ARPC4 | S43 | ochoa | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| P60709 | ACTB | S323 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S325 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63165 | SUMO1 | S31 | ochoa | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
| P63261 | ACTG1 | S323 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S324 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S325 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S325 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78559 | MAP1A | S384 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00688 | FKBP3 | S100 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q01484 | ANK2 | S1733 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02952 | AKAP12 | S1512 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | S1058 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S2315 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S3564 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03188 | CENPC | S75 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03468 | ERCC6 | S486 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q04721 | NOTCH2 | S1778 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q04726 | TLE3 | S221 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q05513 | PRKCZ | S190 | ochoa | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q07864 | POLE | S2080 | ochoa | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
| Q07955 | SRSF1 | S182 | ochoa | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}. |
| Q08357 | SLC20A2 | S256 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08AD1 | CAMSAP2 | S879 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12873 | CHD3 | S313 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12888 | TP53BP1 | S398 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12923 | PTPN13 | S1033 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13017 | ARHGAP5 | S1195 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13153 | PAK1 | S149 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13201 | MMRN1 | S522 | ochoa | Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}. |
| Q13217 | DNAJC3 | S274 | ochoa | DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58) | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}. |
| Q13415 | ORC1 | S196 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13427 | PPIG | S717 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13554 | CAMK2B | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13555 | CAMK2G | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | S235 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13561 | DCTN2 | S83 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q13601 | KRR1 | S238 | ochoa | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q13813 | SPTAN1 | S1075 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14435 | GALNT3 | S134 | ochoa | Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:16638743, PubMed:31932717, PubMed:8663203, PubMed:9295285). Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC (PubMed:8663203, PubMed:9295285). Probably glycosylates fibronectin in vivo (PubMed:9295285). Glycosylates FGF23 (PubMed:16638743, PubMed:31932717). {ECO:0000269|PubMed:16638743, ECO:0000269|PubMed:31932717, ECO:0000269|PubMed:8663203, ECO:0000269|PubMed:9295285}. |
| Q14566 | MCM6 | S762 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14690 | PDCD11 | S26 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14766 | LTBP1 | S1512 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14839 | CHD4 | S1349 | ochoa|psp | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q15032 | R3HDM1 | S111 | ochoa | R3H domain-containing protein 1 | None |
| Q15058 | KIF14 | S1233 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15147 | PLCB4 | S890 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) | Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927). {ECO:0000250|UniProtKB:Q07722, ECO:0000269|PubMed:35284927}. |
| Q15813 | TBCE | S408 | ochoa | Tubulin-specific chaperone E (Tubulin-folding cofactor E) | Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:27666369}. |
| Q15911 | ZFHX3 | S3018 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16543 | CDC37 | S140 | ochoa | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| Q16549 | PCSK7 | S505 | psp | Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7) | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway. |
| Q2PPJ7 | RALGAPA2 | S465 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q4LE39 | ARID4B | S675 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q4LE39 | ARID4B | S912 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q4ZHG4 | FNDC1 | S537 | ochoa | Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) | May be an activator of G protein signaling. {ECO:0000250}. |
| Q562F6 | SGO2 | S1089 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5JRA6 | MIA3 | S727 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5QJE6 | DNTTIP2 | S175 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5QJE6 | DNTTIP2 | S273 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T1R4 | HIVEP3 | S1437 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5UIP0 | RIF1 | S1190 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1384 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VST9 | OBSCN | S840 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT06 | CEP350 | S2294 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VUA4 | ZNF318 | S264 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUA4 | ZNF318 | S1971 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VV52 | ZNF691 | S77 | ochoa | Zinc finger protein 691 | May be involved in transcriptional regulation. |
| Q5VWN6 | TASOR2 | S1174 | ochoa | Protein TASOR 2 | None |
| Q5VWN6 | TASOR2 | S1541 | ochoa | Protein TASOR 2 | None |
| Q5VZK9 | CARMIL1 | S1049 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q641Q2 | WASHC2A | S925 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6ICG6 | KIAA0930 | S328 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6N022 | TENM4 | S41 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6P0N0 | MIS18BP1 | S772 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P444 | MTFR2 | S328 | ochoa | Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) | May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}. |
| Q6PJW8 | CNST | S299 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6UB98 | ANKRD12 | S425 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UXV4 | APOOL | S204 | ochoa | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979). {ECO:0000269|PubMed:23704930, ECO:0000269|PubMed:25764979}. |
| Q6ZV73 | FGD6 | S410 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q6ZV73 | FGD6 | S697 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7Z6E9 | RBBP6 | S1221 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86TI0 | TBC1D1 | S507 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86UR5 | RIMS1 | S1311 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86WB0 | ZC3HC1 | S24 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86YC2 | PALB2 | S157 | ochoa|psp | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q86YN6 | PPARGC1B | S638 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q8IW35 | CEP97 | S752 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IWA0 | WDR75 | S811 | ochoa | WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) | Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q8IWC1 | MAP7D3 | S185 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IXT5 | RBM12B | S250 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8N3Z6 | ZCCHC7 | S142 | ochoa | Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) | None |
| Q8N5H7 | SH2D3C | S196 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8N8Z6 | DCBLD1 | S492 | ochoa | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8N8Z6 | DCBLD1 | S513 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NC26 | ZNF114 | S167 | ochoa | Zinc finger protein 114 | May be involved in transcriptional regulation. |
| Q8ND24 | RNF214 | S150 | ochoa | RING finger protein 214 | None |
| Q8NDI1 | EHBP1 | S742 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NF91 | SYNE1 | S5921 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TDY2 | RB1CC1 | S1222 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEV9 | SMCR8 | S471 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8TF72 | SHROOM3 | S1662 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WXD2 | SCG3 | S37 | ochoa | Secretogranin-3 (Secretogranin III) (SgIII) | Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827). {ECO:0000250|UniProtKB:P47868, ECO:0000269|PubMed:19357184, ECO:0000269|PubMed:29154827}. |
| Q8WY36 | BBX | S478 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q92560 | BAP1 | S609 | ochoa | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92888 | ARHGEF1 | S255 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q96AQ6 | PBXIP1 | S469 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96F05 | C11orf24 | S43 | ochoa | Uncharacterized protein C11orf24 (Protein DM4E3) | None |
| Q96KC8 | DNAJC1 | S363 | ochoa | DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) | May modulate protein synthesis. {ECO:0000250}. |
| Q96KQ7 | EHMT2 | S237 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96QT4 | TRPM7 | S1193 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96SB4 | SRPK1 | S587 | psp | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q99640 | PKMYT1 | S160 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q99728 | BARD1 | S179 | ochoa | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
| Q99741 | CDC6 | S127 | ochoa | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BSM1 | PCGF1 | S118 | ochoa | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479). {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:16943429, ECO:0000269|PubMed:17088287, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:26687479}. |
| Q9BTC0 | DIDO1 | S862 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BTV7 | CABLES2 | S130 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9BUB5 | MKNK1 | S221 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BYW2 | SETD2 | S1263 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZE4 | GTPBP4 | S423 | ochoa | GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1) | Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539). {ECO:0000269|PubMed:20308539, ECO:0000269|PubMed:32669547}. |
| Q9BZF1 | OSBPL8 | S799 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C0B0 | UNK | S447 | ochoa | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9H1X3 | DNAJC25 | S299 | ochoa | DnaJ homolog subfamily C member 25 | None |
| Q9H361 | PABPC3 | S237 | ochoa | Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. |
| Q9H4A5 | GOLPH3L | S23 | ochoa | Golgi phosphoprotein 3-like (GPP34-related protein) | Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}. |
| Q9H6S0 | YTHDC2 | S1208 | ochoa | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}. |
| Q9H7U1 | CCSER2 | S134 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H9F9 | ACTR5 | S291 | ochoa | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}. |
| Q9HAJ7 | SAP30L | S99 | ochoa | Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) | [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240, ECO:0000269|PubMed:26609676}.; FUNCTION: [Isoform 2]: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:18070604}.; FUNCTION: [Isoform 3]: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1. {ECO:0000269|PubMed:18070604}. |
| Q9HC77 | CPAP | S316 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCH5 | SYTL2 | S535 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NPI1 | BRD7 | S265 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NQ11 | ATP13A2 | S151 | ochoa | Polyamine-transporting ATPase 13A2 (EC 7.6.2.-) | ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (PubMed:31996848). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (PubMed:31996848). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Contributes to cellular zinc homeostasis (PubMed:24603074). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (PubMed:26134396). Required for proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (PubMed:24603074, PubMed:25392495). Plays a role in lipid homeostasis (PubMed:31132336). {ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22296644, ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495, ECO:0000269|PubMed:26134396, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28137957, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:31132336, ECO:0000269|PubMed:31996848}. |
| Q9NSC5 | HOMER3 | S256 | ochoa | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9NXL9 | MCM9 | S934 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9NY74 | ETAA1 | S130 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZC9 | SMARCAL1 | S889 | psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9NZM5 | NOP53 | S93 | ochoa | Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) | Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}. |
| Q9UBN7 | HDAC6 | S146 | psp | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UHG0 | DCDC2 | S300 | ochoa | Doublecortin domain-containing protein 2 (Protein RU2S) | Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. |
| Q9UHI6 | DDX20 | S542 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UKA4 | AKAP11 | S1019 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKL3 | CASP8AP2 | S1253 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKM9 | RALY | S63 | ochoa | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9UKY1 | ZHX1 | S202 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9ULD2 | MTUS1 | S1083 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULD9 | ZNF608 | S871 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULL8 | SHROOM4 | S664 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9ULW0 | TPX2 | S634 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UNP9 | PPIE | S91 | ochoa | Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:18258190, PubMed:20460131, PubMed:20677832, PubMed:8977107). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:18258190, PubMed:20460131, PubMed:8977107). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:18258190, PubMed:20541251, PubMed:20677832, PubMed:8977107). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20460131, PubMed:20541251, PubMed:20677832). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:18258190, ECO:0000269|PubMed:20460131, ECO:0000269|PubMed:20541251, ECO:0000269|PubMed:20677832, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:8977107}. |
| Q9UPU5 | USP24 | S117 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPY3 | DICER1 | S1016 | ochoa|psp | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
| Q9UQM7 | CAMK2A | S234 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2H2 | INPP5F | S668 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y3B9 | RRP15 | S240 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y3T9 | NOC2L | S673 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y4D1 | DAAM1 | S1027 | ochoa | Disheveled-associated activator of morphogenesis 1 | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
| Q9Y4G6 | TLN2 | S2172 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y4W2 | LAS1L | S249 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y5S9 | RBM8A | S42 | ochoa | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. {ECO:0000269|PubMed:12121612, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| Q9Y6B6 | SAR1B | S143 | ochoa | Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B) | Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII (PubMed:23433038, PubMed:32358066, PubMed:33186557, PubMed:36369712). The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:23433038, PubMed:32358066, PubMed:33186557). In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis (PubMed:32358066, PubMed:33186557). In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B (PubMed:34290409). {ECO:0000269|PubMed:23433038, ECO:0000269|PubMed:32358066, ECO:0000269|PubMed:33186557, ECO:0000269|PubMed:34290409, ECO:0000269|PubMed:36369712}. |
| Q9Y6J0 | CABIN1 | S386 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6K1 | DNMT3A | S390 | psp | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
| Q13242 | SRSF9 | S172 | Sugiyama | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}. |
| P52907 | CAPZA1 | S219 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| Q92796 | DLG3 | S615 | Sugiyama | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. |
| P05997 | COL5A2 | S1308 | Sugiyama | Collagen alpha-2(V) chain | Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). {ECO:0000250}. |
| P05771 | PRKCB | S476 | Sugiyama | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P17252 | PRKCA | S473 | Sugiyama | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P41743 | PRKCI | S388 | Sugiyama | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| Q9Y5K3 | PCYT1B | S260 | GPS6 | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| Q04759 | PRKCQ | S216 | Sugiyama | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| P06280 | GLA | S176 | Sugiyama | Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (Agalsidase) | Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome. {ECO:0000269|PubMed:10838196, ECO:0000269|PubMed:8804427}. |
| Q9NYU2 | UGGT1 | S366 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| Q96PY6 | NEK1 | S23 | Sugiyama | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| P35372 | OPRM1 | S270 | SIGNOR | Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) | Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.451999e-07 | 6.610 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 9.787782e-07 | 6.009 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.372945e-06 | 5.625 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.012830e-06 | 5.300 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 7.506407e-05 | 4.125 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 7.506407e-05 | 4.125 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.976165e-05 | 4.526 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 7.506407e-05 | 4.125 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.362370e-05 | 4.473 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.977468e-05 | 4.400 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 5.849646e-05 | 4.233 |
| R-HSA-111933 | Calmodulin induced events | 6.785650e-05 | 4.168 |
| R-HSA-111997 | CaM pathway | 6.785650e-05 | 4.168 |
| R-HSA-1640170 | Cell Cycle | 3.358164e-05 | 4.474 |
| R-HSA-9620244 | Long-term potentiation | 1.424018e-04 | 3.846 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.375125e-04 | 3.862 |
| R-HSA-112043 | PLC beta mediated events | 1.222440e-04 | 3.913 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.375125e-04 | 3.862 |
| R-HSA-111996 | Ca-dependent events | 1.532457e-04 | 3.815 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.309701e-04 | 3.636 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.309701e-04 | 3.636 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.309701e-04 | 3.636 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.309701e-04 | 3.636 |
| R-HSA-112040 | G-protein mediated events | 2.025825e-04 | 3.693 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.091414e-04 | 3.680 |
| R-HSA-373760 | L1CAM interactions | 2.391707e-04 | 3.621 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.601855e-04 | 3.443 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.057970e-04 | 3.392 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.066138e-04 | 3.391 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 4.741189e-04 | 3.324 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 4.741189e-04 | 3.324 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 4.741189e-04 | 3.324 |
| R-HSA-111885 | Opioid Signalling | 5.108335e-04 | 3.292 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.099072e-04 | 3.215 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 9.647085e-04 | 3.016 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.104523e-03 | 2.957 |
| R-HSA-397014 | Muscle contraction | 1.189784e-03 | 2.925 |
| R-HSA-4839726 | Chromatin organization | 1.208073e-03 | 2.918 |
| R-HSA-74160 | Gene expression (Transcription) | 1.412598e-03 | 2.850 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.705251e-03 | 2.768 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.905455e-03 | 2.720 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.121368e-03 | 2.673 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.398119e-03 | 2.620 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.602754e-03 | 2.585 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.635736e-03 | 2.579 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 2.873393e-03 | 2.542 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.891826e-03 | 2.539 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.891826e-03 | 2.539 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.159101e-03 | 2.500 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.305869e-03 | 2.481 |
| R-HSA-5578775 | Ion homeostasis | 3.532442e-03 | 2.452 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.657738e-03 | 2.437 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 4.095541e-03 | 2.388 |
| R-HSA-1474244 | Extracellular matrix organization | 3.826010e-03 | 2.417 |
| R-HSA-5673000 | RAF activation | 4.123004e-03 | 2.385 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.278961e-03 | 2.369 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.693198e-03 | 2.329 |
| R-HSA-69205 | G1/S-Specific Transcription | 4.869828e-03 | 2.312 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 5.517779e-03 | 2.258 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.850662e-03 | 2.233 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.763037e-03 | 2.239 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 7.133675e-03 | 2.147 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 7.133675e-03 | 2.147 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 6.550099e-03 | 2.184 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 7.319974e-03 | 2.135 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 7.319974e-03 | 2.135 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.319974e-03 | 2.135 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.319974e-03 | 2.135 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 6.625030e-03 | 2.179 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.152256e-03 | 2.211 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.809823e-03 | 2.167 |
| R-HSA-69206 | G1/S Transition | 6.876411e-03 | 2.163 |
| R-HSA-73894 | DNA Repair | 7.259114e-03 | 2.139 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.491507e-03 | 2.188 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.186465e-03 | 2.143 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.360472e-03 | 2.133 |
| R-HSA-69481 | G2/M Checkpoints | 7.400983e-03 | 2.131 |
| R-HSA-212436 | Generic Transcription Pathway | 7.772512e-03 | 2.109 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 8.141209e-03 | 2.089 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 8.186036e-03 | 2.087 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 8.403295e-03 | 2.076 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 9.289552e-03 | 2.032 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.131212e-03 | 2.039 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 9.350168e-03 | 2.029 |
| R-HSA-3000170 | Syndecan interactions | 1.092004e-02 | 1.962 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 1.092145e-02 | 1.962 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.092145e-02 | 1.962 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.123956e-02 | 1.949 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.123956e-02 | 1.949 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.137243e-02 | 1.944 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.304095e-02 | 1.885 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.304095e-02 | 1.885 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.198996e-02 | 1.921 |
| R-HSA-9659379 | Sensory processing of sound | 1.233065e-02 | 1.909 |
| R-HSA-196025 | Formation of annular gap junctions | 1.308121e-02 | 1.883 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.308121e-02 | 1.883 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.308121e-02 | 1.883 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.308121e-02 | 1.883 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.425439e-02 | 1.846 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.529044e-02 | 1.816 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.533114e-02 | 1.814 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.546678e-02 | 1.811 |
| R-HSA-190873 | Gap junction degradation | 1.541037e-02 | 1.812 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.790320e-02 | 1.747 |
| R-HSA-418597 | G alpha (z) signalling events | 1.767031e-02 | 1.753 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.590467e-02 | 1.798 |
| R-HSA-422475 | Axon guidance | 1.693101e-02 | 1.771 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.651573e-02 | 1.782 |
| R-HSA-1500931 | Cell-Cell communication | 1.740737e-02 | 1.759 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.794169e-02 | 1.746 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.805631e-02 | 1.743 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.859707e-02 | 1.731 |
| R-HSA-3371556 | Cellular response to heat stress | 2.011854e-02 | 1.696 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.053973e-02 | 1.687 |
| R-HSA-162582 | Signal Transduction | 2.061514e-02 | 1.686 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.061823e-02 | 1.686 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.260274e-02 | 1.646 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.532056e-02 | 1.597 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.373298e-02 | 1.625 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.373298e-02 | 1.625 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.373298e-02 | 1.625 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.206228e-02 | 1.656 |
| R-HSA-68886 | M Phase | 2.555182e-02 | 1.593 |
| R-HSA-877300 | Interferon gamma signaling | 2.208665e-02 | 1.656 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.440029e-02 | 1.613 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.271432e-02 | 1.644 |
| R-HSA-194138 | Signaling by VEGF | 2.350224e-02 | 1.629 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.630867e-02 | 1.580 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.630867e-02 | 1.580 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.630867e-02 | 1.580 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.696397e-02 | 1.569 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.696397e-02 | 1.569 |
| R-HSA-421270 | Cell-cell junction organization | 2.763990e-02 | 1.558 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.784174e-02 | 1.555 |
| R-HSA-9675108 | Nervous system development | 2.825281e-02 | 1.549 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.069528e-02 | 1.513 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.069528e-02 | 1.513 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.069528e-02 | 1.513 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.069528e-02 | 1.513 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.069528e-02 | 1.513 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.940176e-02 | 1.532 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 3.599425e-02 | 1.444 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.952868e-02 | 1.530 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.079202e-02 | 1.512 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 3.069528e-02 | 1.513 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.263193e-02 | 1.486 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.409308e-02 | 1.467 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.313555e-02 | 1.480 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.046920e-02 | 1.516 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.599425e-02 | 1.444 |
| R-HSA-418990 | Adherens junctions interactions | 3.455115e-02 | 1.462 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.798788e-02 | 1.420 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.798788e-02 | 1.420 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.903498e-02 | 1.409 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.948388e-02 | 1.404 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.001684e-02 | 1.398 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.203633e-02 | 1.376 |
| R-HSA-9675151 | Disorders of Developmental Biology | 4.309611e-02 | 1.366 |
| R-HSA-5689603 | UCH proteinases | 4.358465e-02 | 1.361 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.358465e-02 | 1.361 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 4.568916e-02 | 1.340 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.353981e-02 | 1.271 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.110598e-02 | 1.292 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 5.462307e-02 | 1.263 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.330808e-02 | 1.273 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 5.067014e-02 | 1.295 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.876647e-02 | 1.312 |
| R-HSA-5693538 | Homology Directed Repair | 5.722749e-02 | 1.242 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.610144e-02 | 1.336 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 5.067014e-02 | 1.295 |
| R-HSA-68877 | Mitotic Prometaphase | 5.007834e-02 | 1.300 |
| R-HSA-437239 | Recycling pathway of L1 | 5.570531e-02 | 1.254 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.096204e-02 | 1.293 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.436273e-02 | 1.353 |
| R-HSA-157118 | Signaling by NOTCH | 5.284943e-02 | 1.277 |
| R-HSA-9675135 | Diseases of DNA repair | 5.330808e-02 | 1.273 |
| R-HSA-445144 | Signal transduction by L1 | 5.868089e-02 | 1.232 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 5.868089e-02 | 1.232 |
| R-HSA-71288 | Creatine metabolism | 5.868089e-02 | 1.232 |
| R-HSA-373753 | Nephrin family interactions | 5.868089e-02 | 1.232 |
| R-HSA-9694631 | Maturation of nucleoprotein | 5.462307e-02 | 1.263 |
| R-HSA-913531 | Interferon Signaling | 5.381058e-02 | 1.269 |
| R-HSA-983712 | Ion channel transport | 4.609958e-02 | 1.336 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.948661e-02 | 1.306 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.677649e-02 | 1.330 |
| R-HSA-446728 | Cell junction organization | 4.574525e-02 | 1.340 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.045200e-02 | 1.219 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.045200e-02 | 1.219 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.045200e-02 | 1.219 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.045200e-02 | 1.219 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.045200e-02 | 1.219 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.045200e-02 | 1.219 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.045200e-02 | 1.219 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.045200e-02 | 1.219 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.045200e-02 | 1.219 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.045200e-02 | 1.219 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.045200e-02 | 1.219 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 6.045200e-02 | 1.219 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 6.045200e-02 | 1.219 |
| R-HSA-75102 | C6 deamination of adenosine | 6.045200e-02 | 1.219 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.080544e-02 | 1.216 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.080544e-02 | 1.216 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.269958e-02 | 1.203 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 6.283945e-02 | 1.202 |
| R-HSA-72172 | mRNA Splicing | 6.329071e-02 | 1.199 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.843993e-02 | 1.165 |
| R-HSA-72187 | mRNA 3'-end processing | 6.843993e-02 | 1.165 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.843993e-02 | 1.165 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.058301e-02 | 1.151 |
| R-HSA-1221632 | Meiotic synapsis | 7.113241e-02 | 1.148 |
| R-HSA-350054 | Notch-HLH transcription pathway | 7.144261e-02 | 1.146 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 7.144261e-02 | 1.146 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.262980e-02 | 1.139 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.447228e-02 | 1.128 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 8.929875e-02 | 1.049 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 8.929875e-02 | 1.049 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.041618e-01 | 0.982 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.948959e-02 | 1.100 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.005338e-01 | 0.998 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.005338e-01 | 0.998 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.842844e-02 | 1.007 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 9.740154e-02 | 1.011 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 9.708154e-02 | 1.013 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 9.926772e-02 | 1.003 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.041618e-01 | 0.982 |
| R-HSA-5334118 | DNA methylation | 1.041618e-01 | 0.982 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.778720e-02 | 1.057 |
| R-HSA-69239 | Synthesis of DNA | 1.169751e-01 | 0.932 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.167808e-01 | 0.933 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 8.500459e-02 | 1.071 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 8.500459e-02 | 1.071 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.547312e-02 | 1.068 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.172632e-01 | 0.931 |
| R-HSA-5694530 | Cargo concentration in the ER | 1.141402e-01 | 0.943 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 8.236635e-02 | 1.084 |
| R-HSA-8953854 | Metabolism of RNA | 7.864280e-02 | 1.104 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 8.968574e-02 | 1.047 |
| R-HSA-447038 | NrCAM interactions | 1.033896e-01 | 0.986 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 1.172632e-01 | 0.931 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 9.926772e-02 | 1.003 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 9.431003e-02 | 1.025 |
| R-HSA-8874081 | MET activates PTK2 signaling | 8.968574e-02 | 1.047 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 9.126003e-02 | 1.040 |
| R-HSA-69275 | G2/M Transition | 1.035634e-01 | 0.985 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.071254e-01 | 0.970 |
| R-HSA-5689901 | Metalloprotease DUBs | 8.968574e-02 | 1.047 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.005338e-01 | 0.998 |
| R-HSA-5576891 | Cardiac conduction | 8.182697e-02 | 1.087 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.157032e-01 | 0.937 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.091204e-01 | 0.962 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.192183e-01 | 0.924 |
| R-HSA-1538133 | G0 and Early G1 | 1.192183e-01 | 0.924 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.192183e-01 | 0.924 |
| R-HSA-69242 | S Phase | 1.197792e-01 | 0.922 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.222071e-01 | 0.913 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.222071e-01 | 0.913 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.226838e-01 | 0.911 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.241883e-01 | 0.906 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.243515e-01 | 0.905 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.243515e-01 | 0.905 |
| R-HSA-9930044 | Nuclear RNA decay | 1.243515e-01 | 0.905 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.243515e-01 | 0.905 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.269699e-01 | 0.896 |
| R-HSA-3000178 | ECM proteoglycans | 1.269699e-01 | 0.896 |
| R-HSA-390522 | Striated Muscle Contraction | 1.295372e-01 | 0.888 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.295372e-01 | 0.888 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.309231e-01 | 0.883 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.443724e-01 | 0.841 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.706522e-01 | 0.768 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.834890e-01 | 0.736 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.834890e-01 | 0.736 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.085720e-01 | 0.681 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.208241e-01 | 0.656 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.208241e-01 | 0.656 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.328874e-01 | 0.633 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.328874e-01 | 0.633 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.328874e-01 | 0.633 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.564586e-01 | 0.591 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.564586e-01 | 0.591 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.347723e-01 | 0.870 |
| R-HSA-419037 | NCAM1 interactions | 1.507474e-01 | 0.822 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.005217e-01 | 0.698 |
| R-HSA-774815 | Nucleosome assembly | 2.005217e-01 | 0.698 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.339337e-01 | 0.873 |
| R-HSA-380287 | Centrosome maturation | 1.410269e-01 | 0.851 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.461203e-01 | 0.609 |
| R-HSA-72649 | Translation initiation complex formation | 2.518598e-01 | 0.599 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.937868e-01 | 0.713 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.339337e-01 | 0.873 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.347723e-01 | 0.870 |
| R-HSA-4641265 | Repression of WNT target genes | 2.208241e-01 | 0.656 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.630218e-01 | 0.788 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.670732e-01 | 0.777 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.085720e-01 | 0.681 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.507474e-01 | 0.822 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.781195e-01 | 0.749 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.177288e-01 | 0.662 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.309231e-01 | 0.883 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.309231e-01 | 0.883 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.576143e-01 | 0.802 |
| R-HSA-176974 | Unwinding of DNA | 1.706522e-01 | 0.768 |
| R-HSA-68952 | DNA replication initiation | 1.834890e-01 | 0.736 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.961279e-01 | 0.707 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.208241e-01 | 0.656 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.328874e-01 | 0.633 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.564586e-01 | 0.591 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.453801e-01 | 0.837 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.439323e-01 | 0.613 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.782191e-01 | 0.749 |
| R-HSA-1500620 | Meiosis | 1.782191e-01 | 0.749 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.576143e-01 | 0.802 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.725817e-01 | 0.763 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.339309e-01 | 0.631 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.507474e-01 | 0.822 |
| R-HSA-75072 | mRNA Editing | 1.706522e-01 | 0.768 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.834890e-01 | 0.736 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.834890e-01 | 0.736 |
| R-HSA-9710421 | Defective pyroptosis | 1.892747e-01 | 0.723 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.743831e-01 | 0.758 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.614476e-01 | 0.792 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.400541e-01 | 0.854 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.329647e-01 | 0.876 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.400541e-01 | 0.854 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.576028e-01 | 0.589 |
| R-HSA-112316 | Neuronal System | 1.451636e-01 | 0.838 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.892747e-01 | 0.723 |
| R-HSA-428540 | Activation of RAC1 | 2.085720e-01 | 0.681 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.208241e-01 | 0.656 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.208241e-01 | 0.656 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 2.447646e-01 | 0.611 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.304352e-01 | 0.885 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.374645e-01 | 0.862 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.592860e-01 | 0.798 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.337816e-01 | 0.874 |
| R-HSA-199991 | Membrane Trafficking | 2.471677e-01 | 0.607 |
| R-HSA-597592 | Post-translational protein modification | 1.371450e-01 | 0.863 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.005217e-01 | 0.698 |
| R-HSA-8963888 | Chylomicron assembly | 1.961279e-01 | 0.707 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.447646e-01 | 0.611 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.564586e-01 | 0.591 |
| R-HSA-190828 | Gap junction trafficking | 1.948878e-01 | 0.710 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.174987e-01 | 0.663 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.453801e-01 | 0.837 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.564586e-01 | 0.591 |
| R-HSA-9931953 | Biofilm formation | 1.561537e-01 | 0.806 |
| R-HSA-5617833 | Cilium Assembly | 2.288573e-01 | 0.640 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.518961e-01 | 0.818 |
| R-HSA-68875 | Mitotic Prophase | 1.585037e-01 | 0.800 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.328874e-01 | 0.633 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 2.564586e-01 | 0.591 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.232280e-01 | 0.651 |
| R-HSA-4086400 | PCP/CE pathway | 1.518961e-01 | 0.818 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.555802e-01 | 0.808 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.882114e-01 | 0.725 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.706522e-01 | 0.768 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.834890e-01 | 0.736 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.447646e-01 | 0.611 |
| R-HSA-5688426 | Deubiquitination | 2.600626e-01 | 0.585 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.208241e-01 | 0.656 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.328874e-01 | 0.633 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.118446e-01 | 0.674 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.232280e-01 | 0.651 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.706522e-01 | 0.768 |
| R-HSA-9833482 | PKR-mediated signaling | 1.592860e-01 | 0.798 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.381227e-01 | 0.623 |
| R-HSA-190236 | Signaling by FGFR | 2.422414e-01 | 0.616 |
| R-HSA-8875878 | MET promotes cell motility | 1.561537e-01 | 0.806 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.564586e-01 | 0.591 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.779506e-01 | 0.750 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 2.061747e-01 | 0.686 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.410255e-01 | 0.851 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.374645e-01 | 0.862 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.328874e-01 | 0.633 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.463719e-01 | 0.608 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.447646e-01 | 0.611 |
| R-HSA-2514856 | The phototransduction cascade | 2.346577e-01 | 0.630 |
| R-HSA-75153 | Apoptotic execution phase | 2.061747e-01 | 0.686 |
| R-HSA-9679506 | SARS-CoV Infections | 1.912939e-01 | 0.718 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.633479e-01 | 0.579 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.633479e-01 | 0.579 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.679723e-01 | 0.572 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 2.679723e-01 | 0.572 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.748383e-01 | 0.561 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.748383e-01 | 0.561 |
| R-HSA-69306 | DNA Replication | 2.779002e-01 | 0.556 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.793084e-01 | 0.554 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.793084e-01 | 0.554 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.793084e-01 | 0.554 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.793084e-01 | 0.554 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.793084e-01 | 0.554 |
| R-HSA-1566977 | Fibronectin matrix formation | 2.793084e-01 | 0.554 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.805810e-01 | 0.552 |
| R-HSA-191859 | snRNP Assembly | 2.805810e-01 | 0.552 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.813413e-01 | 0.551 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.813413e-01 | 0.551 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.816492e-01 | 0.550 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.863202e-01 | 0.543 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.881791e-01 | 0.540 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.904696e-01 | 0.537 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.904696e-01 | 0.537 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.904696e-01 | 0.537 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.920547e-01 | 0.535 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.977833e-01 | 0.526 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.014586e-01 | 0.521 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.014586e-01 | 0.521 |
| R-HSA-164378 | PKA activation in glucagon signalling | 3.014586e-01 | 0.521 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.014586e-01 | 0.521 |
| R-HSA-3928664 | Ephrin signaling | 3.014586e-01 | 0.521 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.014586e-01 | 0.521 |
| R-HSA-163615 | PKA activation | 3.014586e-01 | 0.521 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.014586e-01 | 0.521 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.014586e-01 | 0.521 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.014586e-01 | 0.521 |
| R-HSA-373755 | Semaphorin interactions | 3.035047e-01 | 0.518 |
| R-HSA-68882 | Mitotic Anaphase | 3.081840e-01 | 0.511 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.112097e-01 | 0.507 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.122782e-01 | 0.505 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.122782e-01 | 0.505 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.122782e-01 | 0.505 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.149217e-01 | 0.502 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.160641e-01 | 0.500 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.229308e-01 | 0.491 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.229308e-01 | 0.491 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.229308e-01 | 0.491 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.304775e-01 | 0.481 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.304775e-01 | 0.481 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.319662e-01 | 0.479 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.334190e-01 | 0.477 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.334190e-01 | 0.477 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.334190e-01 | 0.477 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.334190e-01 | 0.477 |
| R-HSA-202040 | G-protein activation | 3.334190e-01 | 0.477 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.334190e-01 | 0.477 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.334190e-01 | 0.477 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.376221e-01 | 0.472 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.405915e-01 | 0.468 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.432636e-01 | 0.464 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.437454e-01 | 0.464 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.488897e-01 | 0.457 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.488897e-01 | 0.457 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 3.488897e-01 | 0.457 |
| R-HSA-73886 | Chromosome Maintenance | 3.516377e-01 | 0.454 |
| R-HSA-418594 | G alpha (i) signalling events | 3.517699e-01 | 0.454 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.539125e-01 | 0.451 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.544997e-01 | 0.450 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.546410e-01 | 0.450 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.581543e-01 | 0.446 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.600839e-01 | 0.444 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.600839e-01 | 0.444 |
| R-HSA-4086398 | Ca2+ pathway | 3.600927e-01 | 0.444 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.600927e-01 | 0.444 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.639226e-01 | 0.439 |
| R-HSA-429947 | Deadenylation of mRNA | 3.737783e-01 | 0.427 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.737783e-01 | 0.427 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.737783e-01 | 0.427 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.737783e-01 | 0.427 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.737783e-01 | 0.427 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.737783e-01 | 0.427 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.737783e-01 | 0.427 |
| R-HSA-2559583 | Cellular Senescence | 3.757119e-01 | 0.425 |
| R-HSA-195721 | Signaling by WNT | 3.763629e-01 | 0.424 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.767614e-01 | 0.424 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.767614e-01 | 0.424 |
| R-HSA-114608 | Platelet degranulation | 3.811228e-01 | 0.419 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.822784e-01 | 0.418 |
| R-HSA-3000157 | Laminin interactions | 3.834819e-01 | 0.416 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 3.834819e-01 | 0.416 |
| R-HSA-420029 | Tight junction interactions | 3.834819e-01 | 0.416 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.834819e-01 | 0.416 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.834819e-01 | 0.416 |
| R-HSA-3214842 | HDMs demethylate histones | 3.834819e-01 | 0.416 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.834819e-01 | 0.416 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.834819e-01 | 0.416 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.877746e-01 | 0.411 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.930357e-01 | 0.406 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.930357e-01 | 0.406 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.930357e-01 | 0.406 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.930357e-01 | 0.406 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 3.930357e-01 | 0.406 |
| R-HSA-3295583 | TRP channels | 3.930357e-01 | 0.406 |
| R-HSA-70635 | Urea cycle | 3.930357e-01 | 0.406 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.930357e-01 | 0.406 |
| R-HSA-1474165 | Reproduction | 3.978469e-01 | 0.400 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.987018e-01 | 0.399 |
| R-HSA-6806834 | Signaling by MET | 3.987018e-01 | 0.399 |
| R-HSA-9843745 | Adipogenesis | 4.020097e-01 | 0.396 |
| R-HSA-8949613 | Cristae formation | 4.024420e-01 | 0.395 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.024420e-01 | 0.395 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 4.024420e-01 | 0.395 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.037076e-01 | 0.394 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.061645e-01 | 0.391 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 4.117032e-01 | 0.385 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.208213e-01 | 0.376 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.208213e-01 | 0.376 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.208213e-01 | 0.376 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.268047e-01 | 0.370 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.297987e-01 | 0.367 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.297987e-01 | 0.367 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.297987e-01 | 0.367 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.297987e-01 | 0.367 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.297987e-01 | 0.367 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.297987e-01 | 0.367 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 4.362002e-01 | 0.360 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.386375e-01 | 0.358 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.386375e-01 | 0.358 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.386375e-01 | 0.358 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 4.386375e-01 | 0.358 |
| R-HSA-182971 | EGFR downregulation | 4.386375e-01 | 0.358 |
| R-HSA-6807070 | PTEN Regulation | 4.390696e-01 | 0.357 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.414551e-01 | 0.355 |
| R-HSA-9664407 | Parasite infection | 4.431361e-01 | 0.353 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.431361e-01 | 0.353 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.431361e-01 | 0.353 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.466831e-01 | 0.350 |
| R-HSA-69190 | DNA strand elongation | 4.473398e-01 | 0.349 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.516525e-01 | 0.345 |
| R-HSA-2262752 | Cellular responses to stress | 4.540022e-01 | 0.343 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.554799e-01 | 0.342 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.559078e-01 | 0.341 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.559078e-01 | 0.341 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.559078e-01 | 0.341 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.559078e-01 | 0.341 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.559078e-01 | 0.341 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.559078e-01 | 0.341 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.559078e-01 | 0.341 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.570565e-01 | 0.340 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.643434e-01 | 0.333 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 4.643434e-01 | 0.333 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.643434e-01 | 0.333 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.643434e-01 | 0.333 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.643434e-01 | 0.333 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.643434e-01 | 0.333 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.643434e-01 | 0.333 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.673174e-01 | 0.330 |
| R-HSA-388396 | GPCR downstream signalling | 4.698670e-01 | 0.328 |
| R-HSA-391251 | Protein folding | 4.724047e-01 | 0.326 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.724047e-01 | 0.326 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.726487e-01 | 0.325 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.726487e-01 | 0.325 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.726487e-01 | 0.325 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.726487e-01 | 0.325 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.726487e-01 | 0.325 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.808258e-01 | 0.318 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.808258e-01 | 0.318 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.888766e-01 | 0.311 |
| R-HSA-3371511 | HSF1 activation | 4.888766e-01 | 0.311 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.888766e-01 | 0.311 |
| R-HSA-8853659 | RET signaling | 4.888766e-01 | 0.311 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.909624e-01 | 0.309 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.968031e-01 | 0.304 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.968031e-01 | 0.304 |
| R-HSA-8948216 | Collagen chain trimerization | 4.968031e-01 | 0.304 |
| R-HSA-73887 | Death Receptor Signaling | 5.026077e-01 | 0.299 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.046070e-01 | 0.297 |
| R-HSA-1566948 | Elastic fibre formation | 5.046070e-01 | 0.297 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.046070e-01 | 0.297 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.046070e-01 | 0.297 |
| R-HSA-422356 | Regulation of insulin secretion | 5.071814e-01 | 0.295 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.079815e-01 | 0.294 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.122905e-01 | 0.290 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.122905e-01 | 0.290 |
| R-HSA-201556 | Signaling by ALK | 5.122905e-01 | 0.290 |
| R-HSA-9648002 | RAS processing | 5.122905e-01 | 0.290 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.151072e-01 | 0.288 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.168416e-01 | 0.287 |
| R-HSA-392499 | Metabolism of proteins | 5.183005e-01 | 0.285 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.198552e-01 | 0.284 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.198552e-01 | 0.284 |
| R-HSA-9646399 | Aggrephagy | 5.198552e-01 | 0.284 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.198552e-01 | 0.284 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.198552e-01 | 0.284 |
| R-HSA-202433 | Generation of second messenger molecules | 5.198552e-01 | 0.284 |
| R-HSA-8982491 | Glycogen metabolism | 5.198552e-01 | 0.284 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.254828e-01 | 0.279 |
| R-HSA-1483255 | PI Metabolism | 5.263758e-01 | 0.279 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.273031e-01 | 0.278 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.273031e-01 | 0.278 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.273031e-01 | 0.278 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.273031e-01 | 0.278 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.273031e-01 | 0.278 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.273031e-01 | 0.278 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.309699e-01 | 0.275 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.346359e-01 | 0.272 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.379649e-01 | 0.269 |
| R-HSA-991365 | Activation of GABAB receptors | 5.418554e-01 | 0.266 |
| R-HSA-977444 | GABA B receptor activation | 5.418554e-01 | 0.266 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.418554e-01 | 0.266 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.424169e-01 | 0.266 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.489633e-01 | 0.260 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.489633e-01 | 0.260 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.517315e-01 | 0.258 |
| R-HSA-72312 | rRNA processing | 5.537872e-01 | 0.257 |
| R-HSA-211000 | Gene Silencing by RNA | 5.542099e-01 | 0.256 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.559614e-01 | 0.255 |
| R-HSA-69236 | G1 Phase | 5.559614e-01 | 0.255 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.559614e-01 | 0.255 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.559614e-01 | 0.255 |
| R-HSA-373752 | Netrin-1 signaling | 5.559614e-01 | 0.255 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.587355e-01 | 0.253 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.587355e-01 | 0.253 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.587355e-01 | 0.253 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.628513e-01 | 0.250 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.628513e-01 | 0.250 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.628513e-01 | 0.250 |
| R-HSA-202403 | TCR signaling | 5.676886e-01 | 0.246 |
| R-HSA-8939211 | ESR-mediated signaling | 5.692612e-01 | 0.245 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.696347e-01 | 0.244 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.696347e-01 | 0.244 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.696347e-01 | 0.244 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.696347e-01 | 0.244 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.696347e-01 | 0.244 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.763133e-01 | 0.239 |
| R-HSA-1483191 | Synthesis of PC | 5.763133e-01 | 0.239 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.765104e-01 | 0.239 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.765104e-01 | 0.239 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.765104e-01 | 0.239 |
| R-HSA-9634597 | GPER1 signaling | 5.828887e-01 | 0.234 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.828887e-01 | 0.234 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.828887e-01 | 0.234 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.835246e-01 | 0.234 |
| R-HSA-73893 | DNA Damage Bypass | 5.893624e-01 | 0.230 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.893624e-01 | 0.230 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.979885e-01 | 0.223 |
| R-HSA-912446 | Meiotic recombination | 6.020111e-01 | 0.220 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.020111e-01 | 0.220 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.033130e-01 | 0.219 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.063488e-01 | 0.217 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.081892e-01 | 0.216 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.081892e-01 | 0.216 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.142717e-01 | 0.212 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.142717e-01 | 0.212 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.142717e-01 | 0.212 |
| R-HSA-372790 | Signaling by GPCR | 6.147951e-01 | 0.211 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.202602e-01 | 0.207 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.202602e-01 | 0.207 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.261561e-01 | 0.203 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.319608e-01 | 0.199 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.319608e-01 | 0.199 |
| R-HSA-177929 | Signaling by EGFR | 6.319608e-01 | 0.199 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.319608e-01 | 0.199 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.376757e-01 | 0.195 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.423405e-01 | 0.192 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.423405e-01 | 0.192 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.423405e-01 | 0.192 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.433022e-01 | 0.192 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.488417e-01 | 0.188 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.488417e-01 | 0.188 |
| R-HSA-977443 | GABA receptor activation | 6.542955e-01 | 0.184 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.542955e-01 | 0.184 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.542955e-01 | 0.184 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.542955e-01 | 0.184 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.542955e-01 | 0.184 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.542955e-01 | 0.184 |
| R-HSA-1266738 | Developmental Biology | 6.550071e-01 | 0.184 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.596650e-01 | 0.181 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.596650e-01 | 0.181 |
| R-HSA-1442490 | Collagen degradation | 6.596650e-01 | 0.181 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.647303e-01 | 0.177 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.649513e-01 | 0.177 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.649513e-01 | 0.177 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.649513e-01 | 0.177 |
| R-HSA-186797 | Signaling by PDGF | 6.649513e-01 | 0.177 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.649513e-01 | 0.177 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.721191e-01 | 0.173 |
| R-HSA-5357801 | Programmed Cell Death | 6.824208e-01 | 0.166 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.852914e-01 | 0.164 |
| R-HSA-163685 | Integration of energy metabolism | 6.896939e-01 | 0.161 |
| R-HSA-9658195 | Leishmania infection | 6.915333e-01 | 0.160 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.915333e-01 | 0.160 |
| R-HSA-5173105 | O-linked glycosylation | 6.931148e-01 | 0.159 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.949954e-01 | 0.158 |
| R-HSA-913709 | O-linked glycosylation of mucins | 6.949954e-01 | 0.158 |
| R-HSA-5218859 | Regulated Necrosis | 6.949954e-01 | 0.158 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.965046e-01 | 0.157 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.998635e-01 | 0.155 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.044013e-01 | 0.152 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.044013e-01 | 0.152 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.044013e-01 | 0.152 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.044013e-01 | 0.152 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 7.044013e-01 | 0.152 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.044013e-01 | 0.152 |
| R-HSA-1632852 | Macroautophagy | 7.064892e-01 | 0.151 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.089953e-01 | 0.149 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.089953e-01 | 0.149 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.129929e-01 | 0.147 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.135182e-01 | 0.147 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.135182e-01 | 0.147 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 7.135182e-01 | 0.147 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.135182e-01 | 0.147 |
| R-HSA-109582 | Hemostasis | 7.136664e-01 | 0.147 |
| R-HSA-1483257 | Phospholipid metabolism | 7.248487e-01 | 0.140 |
| R-HSA-8951664 | Neddylation | 7.261874e-01 | 0.139 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.266712e-01 | 0.139 |
| R-HSA-2187338 | Visual phototransduction | 7.287269e-01 | 0.137 |
| R-HSA-216083 | Integrin cell surface interactions | 7.392225e-01 | 0.131 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.432774e-01 | 0.129 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.437264e-01 | 0.129 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.437264e-01 | 0.129 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.437264e-01 | 0.129 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.438012e-01 | 0.129 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.472695e-01 | 0.127 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.472695e-01 | 0.127 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.511997e-01 | 0.124 |
| R-HSA-977225 | Amyloid fiber formation | 7.511997e-01 | 0.124 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.523823e-01 | 0.124 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.550691e-01 | 0.122 |
| R-HSA-9612973 | Autophagy | 7.552114e-01 | 0.122 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.626289e-01 | 0.118 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.663212e-01 | 0.116 |
| R-HSA-109581 | Apoptosis | 7.716078e-01 | 0.113 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.770584e-01 | 0.110 |
| R-HSA-70268 | Pyruvate metabolism | 7.770584e-01 | 0.110 |
| R-HSA-9663891 | Selective autophagy | 7.805271e-01 | 0.108 |
| R-HSA-5619102 | SLC transporter disorders | 7.845347e-01 | 0.105 |
| R-HSA-202424 | Downstream TCR signaling | 7.873041e-01 | 0.104 |
| R-HSA-73884 | Base Excision Repair | 7.873041e-01 | 0.104 |
| R-HSA-1643685 | Disease | 7.934478e-01 | 0.100 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.938726e-01 | 0.100 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.970807e-01 | 0.098 |
| R-HSA-1474290 | Collagen formation | 8.033484e-01 | 0.095 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.094233e-01 | 0.092 |
| R-HSA-168255 | Influenza Infection | 8.151851e-01 | 0.089 |
| R-HSA-157579 | Telomere Maintenance | 8.153113e-01 | 0.089 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 8.153113e-01 | 0.089 |
| R-HSA-416476 | G alpha (q) signalling events | 8.205355e-01 | 0.086 |
| R-HSA-3214847 | HATs acetylate histones | 8.210181e-01 | 0.086 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.238031e-01 | 0.084 |
| R-HSA-70171 | Glycolysis | 8.238052e-01 | 0.084 |
| R-HSA-3781865 | Diseases of glycosylation | 8.259007e-01 | 0.083 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.265492e-01 | 0.083 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.277261e-01 | 0.082 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.292505e-01 | 0.081 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 8.292505e-01 | 0.081 |
| R-HSA-192823 | Viral mRNA Translation | 8.319100e-01 | 0.080 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.345282e-01 | 0.079 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.345282e-01 | 0.079 |
| R-HSA-9833110 | RSV-host interactions | 8.371058e-01 | 0.077 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.418909e-01 | 0.075 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.421416e-01 | 0.075 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.446010e-01 | 0.073 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.493113e-01 | 0.071 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.563374e-01 | 0.067 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.607808e-01 | 0.065 |
| R-HSA-9824446 | Viral Infection Pathways | 8.613205e-01 | 0.065 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.617110e-01 | 0.065 |
| R-HSA-9640148 | Infection with Enterobacteria | 8.617110e-01 | 0.065 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.617110e-01 | 0.065 |
| R-HSA-6798695 | Neutrophil degranulation | 8.681526e-01 | 0.061 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.700978e-01 | 0.060 |
| R-HSA-70326 | Glucose metabolism | 8.712997e-01 | 0.060 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 8.828824e-01 | 0.054 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.847092e-01 | 0.053 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.900212e-01 | 0.051 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.934264e-01 | 0.049 |
| R-HSA-9909396 | Circadian clock | 9.014869e-01 | 0.045 |
| R-HSA-1280218 | Adaptive Immune System | 9.090002e-01 | 0.041 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 9.103618e-01 | 0.041 |
| R-HSA-382551 | Transport of small molecules | 9.155664e-01 | 0.038 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 9.184401e-01 | 0.037 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.209684e-01 | 0.036 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.212816e-01 | 0.036 |
| R-HSA-72766 | Translation | 9.218818e-01 | 0.035 |
| R-HSA-166520 | Signaling by NTRKs | 9.257930e-01 | 0.033 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.298560e-01 | 0.032 |
| R-HSA-1989781 | PPARA activates gene expression | 9.335409e-01 | 0.030 |
| R-HSA-5663205 | Infectious disease | 9.343153e-01 | 0.030 |
| R-HSA-9610379 | HCMV Late Events | 9.356027e-01 | 0.029 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.356027e-01 | 0.029 |
| R-HSA-162587 | HIV Life Cycle | 9.356027e-01 | 0.029 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.366095e-01 | 0.028 |
| R-HSA-168256 | Immune System | 9.372971e-01 | 0.028 |
| R-HSA-449147 | Signaling by Interleukins | 9.392137e-01 | 0.027 |
| R-HSA-72306 | tRNA processing | 9.483568e-01 | 0.023 |
| R-HSA-418555 | G alpha (s) signalling events | 9.491650e-01 | 0.023 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.491650e-01 | 0.023 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.499606e-01 | 0.022 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.507437e-01 | 0.022 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.507437e-01 | 0.022 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.507437e-01 | 0.022 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.598800e-01 | 0.018 |
| R-HSA-9609690 | HCMV Early Events | 9.657412e-01 | 0.015 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.678394e-01 | 0.014 |
| R-HSA-428157 | Sphingolipid metabolism | 9.683436e-01 | 0.014 |
| R-HSA-162906 | HIV Infection | 9.793463e-01 | 0.009 |
| R-HSA-9609646 | HCMV Infection | 9.856530e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.884925e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.931258e-01 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.953659e-01 | 0.002 |
| R-HSA-168249 | Innate Immune System | 9.953725e-01 | 0.002 |
| R-HSA-8957322 | Metabolism of steroids | 9.955732e-01 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.966238e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.974955e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.985749e-01 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.986417e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.997743e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999383e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999903e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.881 | 0.841 | 2 | 0.841 |
COT |
0.828 | 0.063 | 2 | 0.252 |
CLK3 |
0.826 | 0.183 | 1 | 0.876 |
CDC7 |
0.821 | 0.042 | 1 | 0.919 |
CAMK2G |
0.818 | 0.100 | 2 | 0.311 |
DSTYK |
0.816 | 0.104 | 2 | 0.298 |
MOS |
0.815 | 0.056 | 1 | 0.910 |
MARK4 |
0.815 | 0.108 | 4 | 0.910 |
CAMK2B |
0.813 | 0.209 | 2 | 0.387 |
PRPK |
0.813 | -0.021 | -1 | 0.840 |
CAMK1B |
0.811 | 0.013 | -3 | 0.845 |
PDHK4 |
0.810 | 0.055 | 1 | 0.850 |
GCN2 |
0.810 | -0.138 | 2 | 0.182 |
RAF1 |
0.809 | -0.048 | 1 | 0.840 |
PIM3 |
0.809 | 0.005 | -3 | 0.811 |
ULK2 |
0.809 | -0.125 | 2 | 0.189 |
IKKB |
0.808 | -0.022 | -2 | 0.833 |
TSSK2 |
0.807 | 0.053 | -5 | 0.847 |
BMPR2 |
0.807 | -0.002 | -2 | 0.945 |
MTOR |
0.807 | -0.073 | 1 | 0.800 |
NLK |
0.806 | -0.034 | 1 | 0.835 |
NUAK2 |
0.806 | -0.007 | -3 | 0.823 |
GRK1 |
0.806 | 0.082 | -2 | 0.846 |
CAMK2D |
0.806 | 0.115 | -3 | 0.825 |
NDR2 |
0.806 | -0.028 | -3 | 0.812 |
HUNK |
0.805 | -0.075 | 2 | 0.177 |
SKMLCK |
0.805 | 0.071 | -2 | 0.886 |
ATR |
0.805 | 0.012 | 1 | 0.833 |
TBK1 |
0.805 | -0.061 | 1 | 0.717 |
NEK6 |
0.804 | -0.067 | -2 | 0.925 |
PKN3 |
0.804 | -0.019 | -3 | 0.807 |
MST4 |
0.803 | -0.031 | 2 | 0.214 |
CDKL1 |
0.803 | -0.009 | -3 | 0.781 |
ATM |
0.802 | 0.099 | 1 | 0.787 |
AMPKA1 |
0.802 | -0.001 | -3 | 0.833 |
LATS1 |
0.802 | 0.185 | -3 | 0.824 |
ULK1 |
0.802 | -0.126 | -3 | 0.826 |
NEK7 |
0.802 | -0.104 | -3 | 0.860 |
CHAK2 |
0.802 | -0.053 | -1 | 0.864 |
SRPK1 |
0.801 | 0.059 | -3 | 0.723 |
NIK |
0.801 | -0.062 | -3 | 0.866 |
TSSK1 |
0.801 | 0.020 | -3 | 0.850 |
MARK2 |
0.801 | 0.111 | 4 | 0.858 |
IKKE |
0.801 | -0.067 | 1 | 0.713 |
PDHK1 |
0.801 | -0.114 | 1 | 0.825 |
MLK1 |
0.801 | -0.108 | 2 | 0.202 |
BMPR1B |
0.801 | 0.124 | 1 | 0.867 |
WNK1 |
0.800 | -0.029 | -2 | 0.904 |
CAMK2A |
0.800 | 0.086 | 2 | 0.310 |
GRK6 |
0.800 | 0.014 | 1 | 0.866 |
MARK3 |
0.800 | 0.093 | 4 | 0.886 |
GRK5 |
0.800 | -0.081 | -3 | 0.837 |
PIM1 |
0.800 | 0.033 | -3 | 0.760 |
NIM1 |
0.799 | -0.059 | 3 | 0.846 |
IKKA |
0.799 | 0.005 | -2 | 0.816 |
RSK2 |
0.799 | 0.004 | -3 | 0.751 |
PKCD |
0.799 | -0.038 | 2 | 0.185 |
TGFBR2 |
0.798 | -0.062 | -2 | 0.856 |
LATS2 |
0.798 | -0.000 | -5 | 0.784 |
PRKD1 |
0.798 | -0.017 | -3 | 0.795 |
CAMLCK |
0.798 | -0.007 | -2 | 0.893 |
PLK3 |
0.798 | 0.053 | 2 | 0.272 |
NDR1 |
0.798 | -0.059 | -3 | 0.813 |
DAPK2 |
0.798 | -0.017 | -3 | 0.851 |
QSK |
0.798 | 0.043 | 4 | 0.899 |
ERK5 |
0.797 | -0.054 | 1 | 0.799 |
BRSK1 |
0.797 | 0.015 | -3 | 0.771 |
KIS |
0.797 | 0.009 | 1 | 0.711 |
RIPK3 |
0.796 | -0.086 | 3 | 0.797 |
PKN2 |
0.796 | -0.071 | -3 | 0.820 |
MARK1 |
0.796 | 0.087 | 4 | 0.890 |
AMPKA2 |
0.796 | -0.005 | -3 | 0.802 |
CDKL5 |
0.796 | -0.026 | -3 | 0.772 |
P90RSK |
0.795 | -0.021 | -3 | 0.752 |
BCKDK |
0.795 | -0.075 | -1 | 0.790 |
MLK3 |
0.795 | -0.080 | 2 | 0.174 |
WNK3 |
0.794 | -0.152 | 1 | 0.792 |
TGFBR1 |
0.794 | 0.076 | -2 | 0.847 |
PRKD2 |
0.794 | -0.017 | -3 | 0.750 |
GRK4 |
0.794 | -0.063 | -2 | 0.885 |
QIK |
0.794 | -0.026 | -3 | 0.823 |
ALK2 |
0.793 | 0.150 | -2 | 0.856 |
SRPK2 |
0.793 | 0.045 | -3 | 0.651 |
NUAK1 |
0.793 | -0.025 | -3 | 0.775 |
RSK3 |
0.793 | -0.030 | -3 | 0.744 |
HIPK4 |
0.793 | -0.018 | 1 | 0.787 |
CLK2 |
0.792 | 0.106 | -3 | 0.728 |
PLK1 |
0.792 | -0.027 | -2 | 0.891 |
SIK |
0.792 | 0.012 | -3 | 0.744 |
MASTL |
0.792 | -0.175 | -2 | 0.896 |
SSTK |
0.792 | 0.050 | 4 | 0.878 |
MAPKAPK2 |
0.791 | 0.032 | -3 | 0.709 |
BRSK2 |
0.791 | -0.022 | -3 | 0.799 |
ANKRD3 |
0.791 | -0.133 | 1 | 0.824 |
ICK |
0.791 | -0.023 | -3 | 0.813 |
TTBK2 |
0.790 | -0.173 | 2 | 0.156 |
IRE2 |
0.790 | -0.090 | 2 | 0.180 |
CDK8 |
0.790 | 0.002 | 1 | 0.677 |
CDK1 |
0.790 | 0.056 | 1 | 0.666 |
P70S6KB |
0.790 | -0.043 | -3 | 0.780 |
DNAPK |
0.790 | 0.114 | 1 | 0.713 |
IRE1 |
0.790 | -0.127 | 1 | 0.763 |
DLK |
0.790 | -0.121 | 1 | 0.827 |
NEK9 |
0.789 | -0.172 | 2 | 0.186 |
MAPKAPK3 |
0.789 | -0.033 | -3 | 0.756 |
RIPK1 |
0.789 | -0.090 | 1 | 0.791 |
SRPK3 |
0.789 | 0.033 | -3 | 0.697 |
CDK5 |
0.789 | 0.035 | 1 | 0.710 |
BMPR1A |
0.789 | 0.122 | 1 | 0.859 |
PKCB |
0.789 | -0.064 | 2 | 0.159 |
CDK2 |
0.788 | 0.055 | 1 | 0.737 |
PKR |
0.788 | -0.033 | 1 | 0.817 |
ACVR2A |
0.788 | 0.044 | -2 | 0.859 |
MELK |
0.788 | -0.064 | -3 | 0.790 |
MLK4 |
0.788 | -0.097 | 2 | 0.176 |
ACVR2B |
0.788 | 0.053 | -2 | 0.867 |
ALK4 |
0.788 | -0.020 | -2 | 0.877 |
SNRK |
0.787 | -0.123 | 2 | 0.152 |
MSK2 |
0.787 | -0.014 | -3 | 0.714 |
PKCG |
0.787 | -0.079 | 2 | 0.157 |
PKCA |
0.787 | -0.071 | 2 | 0.157 |
MEK1 |
0.787 | -0.099 | 2 | 0.222 |
PKACG |
0.787 | -0.035 | -2 | 0.769 |
CAMK4 |
0.787 | -0.087 | -3 | 0.804 |
CLK4 |
0.786 | 0.033 | -3 | 0.747 |
RSK4 |
0.785 | 0.010 | -3 | 0.719 |
PKCH |
0.785 | -0.085 | 2 | 0.156 |
MNK1 |
0.785 | -0.024 | -2 | 0.839 |
MLK2 |
0.785 | -0.169 | 2 | 0.191 |
CHAK1 |
0.785 | -0.123 | 2 | 0.142 |
CLK1 |
0.785 | 0.030 | -3 | 0.727 |
MNK2 |
0.785 | -0.033 | -2 | 0.828 |
GRK7 |
0.784 | 0.012 | 1 | 0.805 |
CAMK1G |
0.784 | -0.026 | -3 | 0.746 |
PLK4 |
0.784 | -0.119 | 2 | 0.135 |
AURC |
0.784 | -0.008 | -2 | 0.675 |
CHK1 |
0.784 | -0.003 | -3 | 0.812 |
CDK19 |
0.783 | -0.006 | 1 | 0.639 |
YSK4 |
0.783 | -0.117 | 1 | 0.764 |
PAK1 |
0.783 | -0.066 | -2 | 0.808 |
MSK1 |
0.783 | 0.019 | -3 | 0.722 |
DYRK2 |
0.782 | 0.014 | 1 | 0.703 |
MYLK4 |
0.782 | -0.003 | -2 | 0.805 |
PKCZ |
0.782 | -0.084 | 2 | 0.168 |
PRKD3 |
0.782 | -0.038 | -3 | 0.721 |
CDK13 |
0.781 | -0.003 | 1 | 0.673 |
NEK2 |
0.781 | -0.135 | 2 | 0.170 |
PHKG1 |
0.781 | -0.116 | -3 | 0.806 |
ERK7 |
0.780 | -0.039 | 2 | 0.119 |
PAK3 |
0.780 | -0.098 | -2 | 0.817 |
JNK3 |
0.780 | 0.015 | 1 | 0.683 |
CDK3 |
0.780 | 0.081 | 1 | 0.602 |
VRK2 |
0.780 | -0.221 | 1 | 0.851 |
SMG1 |
0.779 | -0.030 | 1 | 0.779 |
JNK2 |
0.779 | 0.021 | 1 | 0.647 |
DCAMKL1 |
0.779 | -0.050 | -3 | 0.765 |
DCAMKL2 |
0.778 | -0.058 | -3 | 0.794 |
BRAF |
0.778 | -0.015 | -4 | 0.813 |
AURA |
0.777 | 0.006 | -2 | 0.658 |
CDK7 |
0.777 | -0.023 | 1 | 0.696 |
AURB |
0.777 | -0.020 | -2 | 0.680 |
DRAK1 |
0.776 | -0.089 | 1 | 0.791 |
PRP4 |
0.776 | 0.010 | -3 | 0.760 |
GRK2 |
0.776 | -0.032 | -2 | 0.757 |
PIM2 |
0.776 | -0.009 | -3 | 0.729 |
PLK2 |
0.776 | 0.053 | -3 | 0.801 |
PAK2 |
0.776 | -0.089 | -2 | 0.802 |
PRKX |
0.775 | 0.029 | -3 | 0.659 |
PINK1 |
0.775 | -0.079 | 1 | 0.798 |
P38A |
0.775 | -0.006 | 1 | 0.713 |
PKACB |
0.775 | 0.001 | -2 | 0.695 |
PAK6 |
0.774 | -0.051 | -2 | 0.750 |
MEKK3 |
0.774 | -0.130 | 1 | 0.782 |
CAMK1D |
0.774 | 0.023 | -3 | 0.671 |
PASK |
0.774 | 0.014 | -3 | 0.825 |
PERK |
0.774 | -0.145 | -2 | 0.907 |
MAPKAPK5 |
0.774 | -0.047 | -3 | 0.704 |
CDK18 |
0.773 | -0.008 | 1 | 0.629 |
CDK12 |
0.773 | -0.006 | 1 | 0.647 |
CK2A2 |
0.773 | 0.084 | 1 | 0.776 |
TLK2 |
0.773 | -0.119 | 1 | 0.764 |
ERK2 |
0.773 | -0.031 | 1 | 0.698 |
P38B |
0.773 | 0.016 | 1 | 0.657 |
PHKG2 |
0.773 | -0.080 | -3 | 0.782 |
CDK9 |
0.772 | -0.022 | 1 | 0.679 |
ZAK |
0.772 | -0.149 | 1 | 0.764 |
MEKK1 |
0.772 | -0.149 | 1 | 0.774 |
MEKK2 |
0.772 | -0.143 | 2 | 0.190 |
MEK5 |
0.772 | -0.207 | 2 | 0.201 |
HRI |
0.772 | -0.144 | -2 | 0.917 |
DYRK4 |
0.771 | 0.034 | 1 | 0.641 |
P38G |
0.771 | 0.002 | 1 | 0.578 |
PKG2 |
0.771 | -0.041 | -2 | 0.689 |
PKCT |
0.771 | -0.086 | 2 | 0.158 |
TLK1 |
0.771 | -0.100 | -2 | 0.882 |
SGK3 |
0.771 | -0.062 | -3 | 0.741 |
ERK1 |
0.771 | -0.021 | 1 | 0.643 |
WNK4 |
0.771 | -0.115 | -2 | 0.901 |
CDK17 |
0.771 | -0.006 | 1 | 0.584 |
AKT2 |
0.770 | -0.021 | -3 | 0.669 |
IRAK4 |
0.770 | -0.136 | 1 | 0.770 |
HIPK1 |
0.770 | -0.001 | 1 | 0.718 |
PKCI |
0.770 | -0.069 | 2 | 0.162 |
NEK5 |
0.770 | -0.135 | 1 | 0.795 |
SMMLCK |
0.769 | -0.027 | -3 | 0.799 |
TTBK1 |
0.769 | -0.151 | 2 | 0.132 |
MST3 |
0.769 | -0.105 | 2 | 0.176 |
TAO3 |
0.769 | -0.071 | 1 | 0.787 |
DYRK1A |
0.768 | -0.021 | 1 | 0.754 |
CK1E |
0.768 | -0.051 | -3 | 0.520 |
IRAK1 |
0.768 | -0.083 | -1 | 0.725 |
HIPK2 |
0.767 | 0.005 | 1 | 0.623 |
PKCE |
0.766 | -0.047 | 2 | 0.151 |
NEK8 |
0.766 | -0.141 | 2 | 0.183 |
CDK14 |
0.765 | -0.016 | 1 | 0.667 |
EEF2K |
0.765 | -0.046 | 3 | 0.917 |
DAPK3 |
0.764 | 0.015 | -3 | 0.778 |
STK33 |
0.764 | -0.100 | 2 | 0.131 |
CDK16 |
0.764 | 0.002 | 1 | 0.601 |
P70S6K |
0.764 | -0.067 | -3 | 0.691 |
GAK |
0.764 | -0.032 | 1 | 0.807 |
TAO2 |
0.763 | -0.094 | 2 | 0.209 |
HIPK3 |
0.763 | -0.036 | 1 | 0.710 |
CK2A1 |
0.763 | 0.071 | 1 | 0.756 |
DYRK1B |
0.763 | 0.005 | 1 | 0.666 |
P38D |
0.763 | 0.010 | 1 | 0.587 |
CAMKK1 |
0.762 | -0.098 | -2 | 0.838 |
CDK10 |
0.762 | -0.002 | 1 | 0.653 |
CK1D |
0.762 | -0.026 | -3 | 0.469 |
AKT1 |
0.762 | -0.027 | -3 | 0.688 |
GSK3A |
0.761 | -0.010 | 4 | 0.413 |
PKACA |
0.761 | -0.009 | -2 | 0.639 |
GRK3 |
0.761 | -0.037 | -2 | 0.707 |
GSK3B |
0.760 | -0.032 | 4 | 0.406 |
MST2 |
0.760 | -0.085 | 1 | 0.788 |
DYRK3 |
0.760 | -0.003 | 1 | 0.712 |
TNIK |
0.760 | -0.022 | 3 | 0.934 |
CDK6 |
0.759 | 0.004 | 1 | 0.643 |
GCK |
0.759 | -0.046 | 1 | 0.783 |
PDK1 |
0.759 | -0.095 | 1 | 0.785 |
MINK |
0.759 | -0.031 | 1 | 0.766 |
NEK11 |
0.758 | -0.187 | 1 | 0.778 |
HGK |
0.758 | -0.058 | 3 | 0.926 |
MPSK1 |
0.758 | -0.072 | 1 | 0.725 |
DAPK1 |
0.757 | -0.004 | -3 | 0.759 |
JNK1 |
0.757 | 0.001 | 1 | 0.642 |
CAMK1A |
0.757 | -0.016 | -3 | 0.633 |
PKN1 |
0.757 | -0.073 | -3 | 0.709 |
YANK3 |
0.756 | -0.061 | 2 | 0.111 |
CK1G1 |
0.756 | -0.090 | -3 | 0.509 |
NEK4 |
0.755 | -0.139 | 1 | 0.760 |
LRRK2 |
0.755 | -0.126 | 2 | 0.205 |
CAMKK2 |
0.755 | -0.115 | -2 | 0.833 |
LKB1 |
0.755 | -0.116 | -3 | 0.839 |
CDK4 |
0.755 | -0.004 | 1 | 0.634 |
CK1A2 |
0.755 | -0.053 | -3 | 0.468 |
HPK1 |
0.753 | -0.058 | 1 | 0.773 |
TAK1 |
0.753 | -0.123 | 1 | 0.806 |
MEKK6 |
0.752 | -0.173 | 1 | 0.769 |
MAP3K15 |
0.752 | -0.156 | 1 | 0.749 |
PAK4 |
0.752 | -0.069 | -2 | 0.693 |
MST1 |
0.752 | -0.108 | 1 | 0.768 |
CHK2 |
0.752 | -0.047 | -3 | 0.617 |
PAK5 |
0.751 | -0.080 | -2 | 0.690 |
NEK1 |
0.751 | -0.127 | 1 | 0.773 |
KHS2 |
0.751 | -0.014 | 1 | 0.773 |
LOK |
0.750 | -0.117 | -2 | 0.852 |
KHS1 |
0.750 | -0.044 | 1 | 0.758 |
VRK1 |
0.749 | -0.181 | 2 | 0.201 |
RIPK2 |
0.749 | -0.159 | 1 | 0.718 |
MEK2 |
0.749 | -0.172 | 2 | 0.192 |
SLK |
0.749 | -0.088 | -2 | 0.802 |
SBK |
0.747 | 0.007 | -3 | 0.553 |
AKT3 |
0.747 | -0.026 | -3 | 0.602 |
YSK1 |
0.746 | -0.140 | 2 | 0.172 |
SGK1 |
0.746 | -0.024 | -3 | 0.588 |
ROCK2 |
0.746 | -0.031 | -3 | 0.766 |
PDHK3_TYR |
0.745 | 0.064 | 4 | 0.862 |
MRCKB |
0.745 | -0.043 | -3 | 0.720 |
MRCKA |
0.745 | -0.046 | -3 | 0.738 |
HASPIN |
0.744 | -0.008 | -1 | 0.729 |
MAK |
0.744 | 0.007 | -2 | 0.700 |
ALPHAK3 |
0.744 | 0.096 | -1 | 0.764 |
TTK |
0.743 | -0.061 | -2 | 0.888 |
NEK3 |
0.742 | -0.141 | 1 | 0.725 |
MOK |
0.742 | -0.013 | 1 | 0.719 |
BUB1 |
0.740 | -0.049 | -5 | 0.789 |
OSR1 |
0.740 | -0.108 | 2 | 0.172 |
PDHK4_TYR |
0.739 | 0.054 | 2 | 0.262 |
PBK |
0.739 | -0.080 | 1 | 0.707 |
DMPK1 |
0.739 | -0.007 | -3 | 0.742 |
MAP2K6_TYR |
0.738 | 0.055 | -1 | 0.865 |
TESK1_TYR |
0.737 | -0.030 | 3 | 0.922 |
BMPR2_TYR |
0.736 | 0.055 | -1 | 0.845 |
MAP2K4_TYR |
0.736 | -0.026 | -1 | 0.861 |
MYO3B |
0.736 | -0.093 | 2 | 0.184 |
EPHA6 |
0.735 | 0.060 | -1 | 0.829 |
ASK1 |
0.734 | -0.132 | 1 | 0.744 |
MYO3A |
0.734 | -0.099 | 1 | 0.757 |
MAP2K7_TYR |
0.734 | -0.119 | 2 | 0.242 |
PDHK1_TYR |
0.734 | 0.007 | -1 | 0.876 |
PKG1 |
0.733 | -0.065 | -2 | 0.608 |
ROCK1 |
0.732 | -0.044 | -3 | 0.735 |
EPHA4 |
0.732 | 0.088 | 2 | 0.279 |
PINK1_TYR |
0.732 | -0.111 | 1 | 0.840 |
PKMYT1_TYR |
0.731 | -0.110 | 3 | 0.891 |
TAO1 |
0.731 | -0.116 | 1 | 0.706 |
BIKE |
0.731 | -0.026 | 1 | 0.663 |
CRIK |
0.730 | -0.031 | -3 | 0.683 |
LIMK2_TYR |
0.728 | -0.078 | -3 | 0.882 |
INSRR |
0.727 | 0.061 | 3 | 0.796 |
EPHB4 |
0.726 | 0.001 | -1 | 0.813 |
LIMK1_TYR |
0.726 | -0.128 | 2 | 0.230 |
TYRO3 |
0.725 | -0.084 | 3 | 0.857 |
CK1A |
0.725 | -0.063 | -3 | 0.377 |
YANK2 |
0.725 | -0.065 | 2 | 0.137 |
ROS1 |
0.724 | -0.110 | 3 | 0.831 |
FER |
0.724 | 0.020 | 1 | 0.882 |
DDR1 |
0.723 | -0.027 | 4 | 0.802 |
RET |
0.722 | -0.099 | 1 | 0.788 |
TYK2 |
0.722 | -0.141 | 1 | 0.781 |
YES1 |
0.721 | 0.004 | -1 | 0.802 |
FGFR2 |
0.720 | -0.004 | 3 | 0.822 |
SRMS |
0.720 | 0.058 | 1 | 0.871 |
EPHB2 |
0.720 | 0.047 | -1 | 0.787 |
CSF1R |
0.720 | -0.069 | 3 | 0.826 |
TXK |
0.720 | 0.023 | 1 | 0.854 |
MST1R |
0.720 | -0.133 | 3 | 0.844 |
ABL2 |
0.719 | -0.014 | -1 | 0.777 |
STLK3 |
0.719 | -0.187 | 1 | 0.729 |
FGR |
0.719 | -0.054 | 1 | 0.820 |
JAK2 |
0.719 | -0.123 | 1 | 0.781 |
EPHB3 |
0.719 | 0.009 | -1 | 0.788 |
JAK3 |
0.718 | -0.080 | 1 | 0.781 |
EPHB1 |
0.718 | -0.015 | 1 | 0.859 |
TEK |
0.717 | -0.040 | 3 | 0.796 |
HCK |
0.717 | -0.007 | -1 | 0.767 |
EPHA7 |
0.716 | 0.032 | 2 | 0.264 |
PDGFRB |
0.716 | -0.106 | 3 | 0.848 |
EPHA5 |
0.716 | 0.092 | 2 | 0.296 |
FLT3 |
0.716 | -0.068 | 3 | 0.847 |
EPHA3 |
0.716 | -0.008 | 2 | 0.253 |
BLK |
0.714 | 0.022 | -1 | 0.778 |
ITK |
0.714 | -0.049 | -1 | 0.741 |
ABL1 |
0.714 | -0.059 | -1 | 0.765 |
FGFR1 |
0.714 | -0.070 | 3 | 0.798 |
KIT |
0.714 | -0.059 | 3 | 0.829 |
AAK1 |
0.713 | -0.008 | 1 | 0.555 |
LCK |
0.713 | -0.008 | -1 | 0.769 |
PTK2 |
0.713 | 0.041 | -1 | 0.755 |
TNNI3K_TYR |
0.713 | -0.106 | 1 | 0.766 |
MERTK |
0.712 | -0.053 | 3 | 0.800 |
TNK2 |
0.711 | -0.092 | 3 | 0.783 |
TNK1 |
0.711 | -0.120 | 3 | 0.833 |
FGFR3 |
0.711 | -0.030 | 3 | 0.796 |
AXL |
0.710 | -0.086 | 3 | 0.802 |
INSR |
0.710 | -0.024 | 3 | 0.779 |
FYN |
0.710 | 0.045 | -1 | 0.747 |
ALK |
0.710 | -0.090 | 3 | 0.765 |
PDGFRA |
0.710 | -0.156 | 3 | 0.856 |
NTRK1 |
0.710 | -0.055 | -1 | 0.803 |
BTK |
0.709 | -0.063 | -1 | 0.705 |
TEC |
0.709 | -0.049 | -1 | 0.685 |
LTK |
0.709 | -0.068 | 3 | 0.777 |
NEK10_TYR |
0.709 | -0.116 | 1 | 0.688 |
BMX |
0.708 | -0.025 | -1 | 0.673 |
KDR |
0.708 | -0.125 | 3 | 0.788 |
ERBB2 |
0.707 | -0.070 | 1 | 0.761 |
LYN |
0.707 | 0.017 | 3 | 0.769 |
EPHA8 |
0.707 | 0.008 | -1 | 0.764 |
EGFR |
0.706 | 0.009 | 1 | 0.678 |
JAK1 |
0.706 | -0.138 | 1 | 0.723 |
PTK2B |
0.705 | -0.039 | -1 | 0.724 |
FLT1 |
0.705 | -0.086 | -1 | 0.819 |
WEE1_TYR |
0.705 | -0.105 | -1 | 0.725 |
CK1G3 |
0.704 | -0.057 | -3 | 0.329 |
FRK |
0.704 | -0.083 | -1 | 0.784 |
FLT4 |
0.704 | -0.112 | 3 | 0.787 |
MET |
0.703 | -0.107 | 3 | 0.812 |
DDR2 |
0.702 | 0.009 | 3 | 0.773 |
SYK |
0.702 | 0.050 | -1 | 0.747 |
NTRK2 |
0.702 | -0.126 | 3 | 0.790 |
PTK6 |
0.701 | -0.177 | -1 | 0.684 |
EPHA1 |
0.701 | -0.073 | 3 | 0.785 |
EPHA2 |
0.701 | 0.023 | -1 | 0.741 |
FGFR4 |
0.700 | -0.005 | -1 | 0.751 |
IGF1R |
0.700 | -0.017 | 3 | 0.726 |
NTRK3 |
0.700 | -0.070 | -1 | 0.758 |
MATK |
0.699 | -0.082 | -1 | 0.723 |
SRC |
0.699 | -0.027 | -1 | 0.747 |
CSK |
0.698 | -0.069 | 2 | 0.244 |
ERBB4 |
0.693 | 0.005 | 1 | 0.705 |
CK1G2 |
0.686 | -0.050 | -3 | 0.426 |
MUSK |
0.683 | -0.146 | 1 | 0.656 |
FES |
0.678 | -0.086 | -1 | 0.652 |
ZAP70 |
0.668 | -0.050 | -1 | 0.672 |