Motif 780 (n=165)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S894 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| H3BU86 | STX16-NPEPL1 | S41 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| H7C0S8 | None | S222 | ochoa | Argininosuccinate lyase (Calcitonin gene-related peptide-receptor component protein) (DNA-directed RNA polymerase III subunit RPC9) | Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000256|ARBA:ARBA00043924}.; FUNCTION: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway. {ECO:0000256|ARBA:ARBA00045522}.; FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000256|ARBA:ARBA00045808}. |
| M0QYT0 | None | S207 | ochoa | RRM domain-containing protein | None |
| O14662 | STX16 | S41 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O14976 | GAK | S1029 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O43399 | TPD52L2 | S84 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43504 | LAMTOR5 | S26 | ochoa|psp | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:29158492, PubMed:30181260). When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (PubMed:12773388). {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}. |
| O43524 | FOXO3 | S209 | psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O60701 | UGDH | S216 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O75152 | ZC3H11A | S625 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75170 | PPP6R2 | S289 | ochoa|psp | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| O75175 | CNOT3 | S242 | ochoa | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}. |
| O75369 | FLNB | S2307 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75575 | CRCP | S37 | ochoa | DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:Q9C0Z9, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000250|UniProtKB:O35427}. |
| O94986 | CEP152 | S1612 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95714 | HERC2 | S2010 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| P06400 | RB1 | S567 | psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P08237 | PFKM | S762 | psp | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| P08684 | CYP3A4 | S478 | psp | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P09038 | FGF2 | S242 | ochoa | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) | Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879). {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:29501879, ECO:0000269|PubMed:3732516, ECO:0000269|PubMed:3964259}. |
| P0DMU7 | CT45A6 | S115 | ochoa | Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) | None |
| P0DMU8 | CT45A5 | S115 | ochoa | Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) | None |
| P0DMV0 | CT45A7 | S115 | ochoa | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | None |
| P10114 | RAP2A | S66 | ochoa | Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK (PubMed:14966141, PubMed:15342639, PubMed:18930710, PubMed:20159449). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:35293963}. |
| P10114 | RAP2A | S129 | ochoa | Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK (PubMed:14966141, PubMed:15342639, PubMed:18930710, PubMed:20159449). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). {ECO:0000269|PubMed:14966141, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:16540189, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:35293963}. |
| P12883 | MYH7 | S1718 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13611 | VCAN | S566 | ochoa | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
| P15036 | ETS2 | S319 | ochoa|psp | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P18583 | SON | S1491 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P23634 | ATP2B4 | S1115 | ochoa|psp | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P28749 | RBL1 | S1009 | psp | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P30291 | WEE1 | S211 | psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P30305 | CDC25B | S50 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30566 | ADSL | S289 | ochoa | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| P32926 | DSG3 | S971 | ochoa | Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}. |
| P33981 | TTK | S582 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35222 | CTNNB1 | S311 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P38398 | BRCA1 | S1280 | ochoa|psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42684 | ABL2 | S203 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P42704 | LRPPRC | S121 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P46013 | MKI67 | S235 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48169 | GABRA4 | S446 | ochoa | Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:35355020). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:35355020). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:35355020). {ECO:0000250|UniProtKB:Q9D6F4, ECO:0000269|PubMed:35355020}. |
| P48552 | NRIP1 | S518 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P49327 | FASN | S1997 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S1249 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51955 | NEK2 | S368 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P54296 | MYOM2 | S737 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55082 | MFAP3 | S300 | ochoa | Microfibril-associated glycoprotein 3 | Component of the elastin-associated microfibrils. |
| P55957 | BID | S64 | ochoa|psp | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P61225 | RAP2B | S66 | ochoa | Ras-related protein Rap-2b (EC 3.6.5.2) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}. |
| P78545 | ELF3 | S68 | psp | ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}. |
| Q01814 | ATP2B2 | S1201 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q03188 | CENPC | S55 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04656 | ATP7A | S1469 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q08211 | DHX9 | S130 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q08357 | SLC20A2 | S375 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08378 | GOLGA3 | S268 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q13011 | ECH1 | S37 | ochoa | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) | Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}. |
| Q13085 | ACACA | S1201 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13115 | DUSP4 | S345 | ochoa | Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}. |
| Q13200 | PSMD2 | S436 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
| Q13393 | PLD1 | S561 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13576 | IQGAP2 | S1061 | ochoa | Ras GTPase-activating-like protein IQGAP2 | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
| Q14008 | CKAP5 | S1995 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14154 | DELE1 | S473 | ochoa | DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1) (cDELE1)] | Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks (PubMed:32132706, PubMed:32132707, PubMed:35388015, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed:35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:35388015, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}.; FUNCTION: [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. {ECO:0000269|PubMed:37327776}.; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546). Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (PubMed:38340717). {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}. |
| Q14156 | EFR3A | S791 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14315 | FLNC | S2428 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14669 | TRIP12 | S312 | ochoa|psp | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14761 | PTPRCAP | S99 | ochoa|psp | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
| Q15149 | PLEC | S4015 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15811 | ITSN1 | S1206 | ochoa | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
| Q1W6H9 | FAM110C | S241 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q2KHR2 | RFX7 | S1290 | ochoa | DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) | Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}. |
| Q2LD37 | BLTP1 | S1436 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q3KQU3 | MAP7D1 | S232 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4AC94 | C2CD3 | S301 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q4G0P3 | HYDIN | S3972 | ochoa | Hydrocephalus-inducing protein homolog | Required for ciliary motility. {ECO:0000250}. |
| Q4KWH8 | PLCH1 | S1028 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q53GL0 | PLEKHO1 | S221 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
| Q5CZC0 | FSIP2 | S3890 | ochoa | Fibrous sheath-interacting protein 2 | Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}. |
| Q5HYN5 | CT45A1 | S115 | ochoa | Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) | None |
| Q5SWA1 | PPP1R15B | S203 | ochoa | Protein phosphatase 1 regulatory subunit 15B | Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269|PubMed:26159176, ECO:0000269|PubMed:26307080}. |
| Q5T7B8 | KIF24 | S524 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5UE93 | PIK3R6 | S663 | ochoa | Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP) | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}. |
| Q5VVW2 | GARNL3 | S424 | ochoa | GTPase-activating Rap/Ran-GAP domain-like protein 3 | None |
| Q63HN8 | RNF213 | S3525 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q66K74 | MAP1S | S321 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68DQ2 | CRYBG3 | S395 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6IQ55 | TTBK2 | S484 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6NZI2 | CAVIN1 | S88 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P0N0 | MIS18BP1 | S19 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6PFW1 | PPIP5K1 | S1036 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6UUV7 | CRTC3 | S539 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6WKZ4 | RAB11FIP1 | S300 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZN30 | BNC2 | S904 | ochoa | Zinc finger protein basonuclin-2 | Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). {ECO:0000269|PubMed:14988505, ECO:0000269|PubMed:31051115}. |
| Q6ZU52 | KIAA0408 | S128 | ochoa | Uncharacterized protein KIAA0408 | None |
| Q7L9B9 | EEPD1 | S428 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z3S7 | CACNA2D4 | S499 | ochoa | Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}. |
| Q7Z6B0 | CCDC91 | S79 | ochoa | Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) | Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}. |
| Q7Z6J2 | TAMALIN | S235 | ochoa | Protein TAMALIN (General receptor for phosphoinositides 1-associated scaffold protein) (GRP1-associated scaffold protein) | Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. {ECO:0000250}. |
| Q86T82 | USP37 | S210 | ochoa | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:26299517, ECO:0000269|PubMed:27296872, ECO:0000269|PubMed:31911859, ECO:0000269|PubMed:34509474, ECO:0000269|PubMed:34606619}. |
| Q86UY5 | FAM83A | S113 | ochoa | Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) | Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}. |
| Q86WB0 | ZC3HC1 | S87 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q8IUG5 | MYO18B | S2245 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IVL1 | NAV2 | S1019 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IY63 | AMOTL1 | S828 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8N205 | SYNE4 | S318 | ochoa | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}. |
| Q8NAN2 | MIGA1 | S289 | ochoa | Mitoguardin 1 (Protein FAM73A) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q8NCN2 | ZBTB34 | S207 | ochoa | Zinc finger and BTB domain-containing protein 34 | May be a transcriptional repressor. {ECO:0000269|PubMed:16718364}. |
| Q8ND82 | ZNF280C | S285 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
| Q8NHU0 | CT45A3 | S115 | ochoa | Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) | None |
| Q8TB61 | SLC35B2 | S137 | ochoa | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2) | Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. {ECO:0000269|PubMed:12716889}. |
| Q8TC44 | POC1B | S321 | ochoa | POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) | Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). Acts as a positive regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:20008567, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:25044745, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:37934472}. |
| Q8TDJ6 | DMXL2 | S1857 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TDW5 | SYTL5 | S396 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TF40 | FNIP1 | S170 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8WWQ8 | STAB2 | S2352 | ochoa | Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)] | Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:15208308, ECO:0000269|PubMed:15572036, ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18434317, ECO:0000269|PubMed:18573870, ECO:0000269|PubMed:19359419}. |
| Q92560 | BAP1 | S276 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92574 | TSC1 | S644 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92599 | SEPTIN8 | S192 | psp | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
| Q92608 | DOCK2 | S1202 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92786 | PROX1 | S179 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q96AE4 | FUBP1 | S84 | ochoa | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96CP6 | GRAMD1A | S415 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96DR7 | ARHGEF26 | S725 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96GE4 | CEP95 | S544 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96HH9 | GRAMD2B | S212 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96NC0 | ZMAT2 | S75 | ochoa | Zinc finger matrin-type protein 2 | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
| Q96QZ7 | MAGI1 | S1118 | ochoa | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3) | Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6RHR9}. |
| Q96SD1 | DCLRE1C | S538 | psp | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. |
| Q99490 | AGAP2 | S927 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q9BTV4 | TMEM43 | S21 | ochoa | Transmembrane protein 43 (Protein LUMA) | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020). {ECO:0000250|UniProtKB:Q9DBS1, ECO:0000269|PubMed:27991920, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34050020}. |
| Q9BWT3 | PAPOLG | S450 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BXL7 | CARD11 | S448 | ochoa | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BXW9 | FANCD2 | S898 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BZF1 | OSBPL8 | S32 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9H2G2 | SLK | S518 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H9A7 | RMI1 | S265 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HBD1 | RC3H2 | S982 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9NQW6 | ANLN | S219 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQW6 | ANLN | S927 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NVN8 | GNL3L | S543 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9UGU0 | TCF20 | S807 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHI6 | DDX20 | S320 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UKE5 | TNIK | S898 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UNH5 | CDC14A | S483 | ochoa | Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}. |
| Q9UPU5 | USP24 | S1612 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPV0 | CEP164 | S1213 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y251 | HPSE | S426 | ochoa | Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] | Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as a procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. {ECO:0000269|PubMed:12213822, ECO:0000269|PubMed:12773484, ECO:0000269|PubMed:15044433, ECO:0000269|PubMed:16452201, ECO:0000269|PubMed:18557927, ECO:0000269|PubMed:18798279, ECO:0000269|PubMed:19244131, ECO:0000269|PubMed:20097882, ECO:0000269|PubMed:20181948, ECO:0000269|PubMed:20309870, ECO:0000269|PubMed:20561914, ECO:0000269|PubMed:21131364}. |
| Q9Y3L5 | RAP2C | S66 | ochoa | Ras-related protein Rap-2c (EC 3.6.5.2) | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. {ECO:0000269|PubMed:17447155}. |
| Q9Y3Q8 | TSC22D4 | S310 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4B5 | MTCL1 | S1616 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4D8 | HECTD4 | S1715 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4G6 | TLN2 | S1666 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y6Q9 | NCOA3 | S543 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P57723 | PCBP4 | S31 | Sugiyama | Poly(rC)-binding protein 4 (Alpha-CP4) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| Q14683 | SMC1A | S514 | Sugiyama | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q6UB35 | MTHFD1L | S401 | Sugiyama | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. |
| Q13049 | TRIM32 | S55 | SIGNOR | E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) | E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:19349376, PubMed:31123703). Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 (PubMed:22745133). Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (PubMed:37543647). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions (PubMed:32918979). Ubiquitinates XIAP and targets it for proteasomal degradation (PubMed:21628460). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376). May ubiquitinate BBS2 (PubMed:22500027). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703). Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (PubMed:34888944). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-45' to initiate autophagy (PubMed:37943659). {ECO:0000250|UniProtKB:Q8CH72, ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:21628460, ECO:0000269|PubMed:22500027, ECO:0000269|PubMed:22745133, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32918979, ECO:0000269|PubMed:34888944, ECO:0000269|PubMed:37543647, ECO:0000269|PubMed:37943659}.; FUNCTION: (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269). Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269). {ECO:0000269|PubMed:7778269}. |
| Q9Y2L5 | TRAPPC8 | S377 | Sugiyama | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
| Q9H8Y5 | ANKZF1 | S126 | Sugiyama | tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) | Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}. |
| Q15349 | RPS6KA2 | S82 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q6P0Q8 | MAST2 | S775 | Sugiyama | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q9H2X6 | HIPK2 | S37 | Sugiyama | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-163765 | ChREBP activates metabolic gene expression | 7.457006e-07 | 6.127 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.680214e-04 | 3.775 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.764502e-04 | 3.753 |
| R-HSA-1640170 | Cell Cycle | 3.068364e-04 | 3.513 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.274824e-04 | 3.278 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.058303e-03 | 2.975 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.502462e-03 | 2.823 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.547342e-03 | 2.810 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.478600e-03 | 2.830 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 3.050582e-03 | 2.516 |
| R-HSA-69275 | G2/M Transition | 2.763932e-03 | 2.558 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.930450e-03 | 2.533 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.427776e-03 | 2.465 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.219265e-03 | 2.654 |
| R-HSA-5617833 | Cilium Assembly | 3.104695e-03 | 2.508 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 3.199335e-03 | 2.495 |
| R-HSA-2559583 | Cellular Senescence | 2.308385e-03 | 2.637 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.528876e-03 | 2.452 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.899145e-03 | 2.409 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.310016e-03 | 2.136 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 7.310016e-03 | 2.136 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.035593e-03 | 2.153 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 9.501880e-03 | 2.022 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 9.501880e-03 | 2.022 |
| R-HSA-936837 | Ion transport by P-type ATPases | 9.960921e-03 | 2.002 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 9.918319e-03 | 2.004 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.063350e-02 | 1.973 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.092163e-02 | 1.962 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.142315e-02 | 1.942 |
| R-HSA-68877 | Mitotic Prometaphase | 1.188068e-02 | 1.925 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.319198e-02 | 1.880 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.357918e-02 | 1.867 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.357918e-02 | 1.867 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.415568e-02 | 1.849 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.474748e-02 | 1.831 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.535471e-02 | 1.814 |
| R-HSA-380287 | Centrosome maturation | 1.597750e-02 | 1.796 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.646565e-02 | 1.783 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.753266e-02 | 1.756 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.271652e-02 | 1.644 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.271652e-02 | 1.644 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 2.271652e-02 | 1.644 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 2.271652e-02 | 1.644 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.230017e-02 | 1.652 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.308417e-02 | 1.637 |
| R-HSA-69481 | G2/M Checkpoints | 2.484879e-02 | 1.605 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2.259432e-02 | 1.646 |
| R-HSA-196780 | Biotin transport and metabolism | 2.054367e-02 | 1.687 |
| R-HSA-1483148 | Synthesis of PG | 2.472575e-02 | 1.607 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 2.472575e-02 | 1.607 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 3.388155e-02 | 1.470 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 3.388155e-02 | 1.470 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 4.491972e-02 | 1.348 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 6.662115e-02 | 1.176 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 6.662115e-02 | 1.176 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.783208e-02 | 1.056 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 9.825706e-02 | 1.008 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 9.825706e-02 | 1.008 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.085635e-01 | 0.964 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.085635e-01 | 0.964 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.085635e-01 | 0.964 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.085635e-01 | 0.964 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 1.085635e-01 | 0.964 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 1.085635e-01 | 0.964 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.187528e-01 | 0.925 |
| R-HSA-444257 | RSK activation | 1.187528e-01 | 0.925 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 1.187528e-01 | 0.925 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.158395e-02 | 1.501 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.401793e-02 | 1.468 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.401793e-02 | 1.468 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.401793e-02 | 1.468 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.401793e-02 | 1.468 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.387852e-01 | 0.858 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.486309e-01 | 0.828 |
| R-HSA-2022923 | DS-GAG biosynthesis | 1.583647e-01 | 0.800 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.583647e-01 | 0.800 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 5.004026e-02 | 1.301 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.679877e-01 | 0.775 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.679877e-01 | 0.775 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.679877e-01 | 0.775 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.679877e-01 | 0.775 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.679877e-01 | 0.775 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.775013e-01 | 0.751 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 1.775013e-01 | 0.751 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.775013e-01 | 0.751 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.194034e-02 | 1.208 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.869067e-01 | 0.728 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.962051e-01 | 0.707 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.962051e-01 | 0.707 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 1.962051e-01 | 0.707 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.053978e-01 | 0.687 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.053978e-01 | 0.687 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 2.144859e-01 | 0.669 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 2.144859e-01 | 0.669 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 2.234706e-01 | 0.651 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.234706e-01 | 0.651 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.323531e-01 | 0.634 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.638686e-02 | 1.579 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 2.498160e-01 | 0.602 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 2.583987e-01 | 0.588 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.583987e-01 | 0.588 |
| R-HSA-774815 | Nucleosome assembly | 1.246241e-01 | 0.904 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.246241e-01 | 0.904 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 2.668837e-01 | 0.574 |
| R-HSA-2022870 | CS-GAG biosynthesis | 2.668837e-01 | 0.574 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 2.668837e-01 | 0.574 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 2.752722e-01 | 0.560 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.917639e-01 | 0.535 |
| R-HSA-1221632 | Meiotic synapsis | 1.558853e-01 | 0.807 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 2.998692e-01 | 0.523 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.503913e-02 | 1.022 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.503913e-02 | 1.022 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 3.158040e-01 | 0.501 |
| R-HSA-191859 | snRNP Assembly | 1.801995e-01 | 0.744 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.801995e-01 | 0.744 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 3.236357e-01 | 0.490 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.386561e-01 | 0.622 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.767693e-01 | 0.558 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.323531e-01 | 0.634 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.909601e-02 | 1.408 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.411345e-01 | 0.618 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.498160e-01 | 0.602 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.752722e-01 | 0.560 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 2.998692e-01 | 0.523 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.735781e-02 | 1.563 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.728723e-02 | 1.112 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.387852e-01 | 0.858 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 2.583987e-01 | 0.588 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 8.135074e-02 | 1.090 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.411345e-01 | 0.618 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.397199e-02 | 1.076 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 7.799735e-02 | 1.108 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.288263e-01 | 0.890 |
| R-HSA-190377 | FGFR2b ligand binding and activation | 1.486309e-01 | 0.828 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.583647e-01 | 0.800 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.775013e-01 | 0.751 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 7.468928e-02 | 1.127 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 7.468928e-02 | 1.127 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.558853e-01 | 0.807 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.558853e-01 | 0.807 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.558853e-01 | 0.807 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.775712e-01 | 0.751 |
| R-HSA-5689603 | UCH proteinases | 2.513473e-01 | 0.600 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 3.158040e-01 | 0.501 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.139394e-02 | 1.146 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.486309e-01 | 0.828 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 7.468928e-02 | 1.127 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 2.323531e-01 | 0.634 |
| R-HSA-6798695 | Neutrophil degranulation | 3.114080e-01 | 0.507 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.133972e-01 | 0.671 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 2.323531e-01 | 0.634 |
| R-HSA-525793 | Myogenesis | 3.078822e-01 | 0.512 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.366498e-01 | 0.864 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.720276e-01 | 0.764 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.678619e-01 | 0.572 |
| R-HSA-165159 | MTOR signalling | 1.133399e-01 | 0.946 |
| R-HSA-5693538 | Homology Directed Repair | 1.947981e-01 | 0.710 |
| R-HSA-202424 | Downstream TCR signaling | 3.147804e-01 | 0.502 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.281767e-02 | 1.368 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.856521e-02 | 1.314 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 6.662115e-02 | 1.176 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 9.825706e-02 | 1.008 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.187528e-01 | 0.925 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.387852e-01 | 0.858 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 1.486309e-01 | 0.828 |
| R-HSA-3000497 | Scavenging by Class H Receptors | 1.583647e-01 | 0.800 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 1.583647e-01 | 0.800 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.583647e-01 | 0.800 |
| R-HSA-202670 | ERKs are inactivated | 1.583647e-01 | 0.800 |
| R-HSA-190322 | FGFR4 ligand binding and activation | 1.775013e-01 | 0.751 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.775013e-01 | 0.751 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 1.869067e-01 | 0.728 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8.135074e-02 | 1.090 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 9.874769e-02 | 1.005 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.411345e-01 | 0.618 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.411345e-01 | 0.618 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.668837e-01 | 0.574 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.752722e-01 | 0.560 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.835652e-01 | 0.547 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.479300e-01 | 0.830 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.158040e-01 | 0.501 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.015982e-02 | 1.221 |
| R-HSA-1500620 | Meiosis | 2.894696e-01 | 0.538 |
| R-HSA-1538133 | G0 and Early G1 | 7.142802e-02 | 1.146 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.627287e-02 | 1.250 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.260000e-01 | 0.646 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 6.505200e-02 | 1.187 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 6.662115e-02 | 1.176 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 6.662115e-02 | 1.176 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.187528e-01 | 0.925 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.387852e-01 | 0.858 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.775013e-01 | 0.751 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 9.518893e-02 | 1.021 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.498160e-01 | 0.602 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.752722e-01 | 0.560 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.668837e-01 | 0.574 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.639204e-01 | 0.785 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.884290e-01 | 0.725 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 1.775013e-01 | 0.751 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 1.962051e-01 | 0.707 |
| R-HSA-9754706 | Atorvastatin ADME | 2.053978e-01 | 0.687 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.234706e-01 | 0.651 |
| R-HSA-9834899 | Specification of the neural plate border | 2.411345e-01 | 0.618 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.679654e-01 | 0.775 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.260000e-01 | 0.646 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 2.279495e-01 | 0.642 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.721024e-02 | 1.326 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.721024e-02 | 1.326 |
| R-HSA-9824272 | Somitogenesis | 1.246241e-01 | 0.904 |
| R-HSA-9766229 | Degradation of CDH1 | 1.400624e-01 | 0.854 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.208327e-01 | 0.918 |
| R-HSA-69236 | G1 Phase | 1.208327e-01 | 0.918 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 5.587769e-02 | 1.253 |
| R-HSA-198753 | ERK/MAPK targets | 3.652258e-02 | 1.437 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 8.474801e-02 | 1.072 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 9.874769e-02 | 1.005 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.158040e-01 | 0.501 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.246241e-01 | 0.904 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.246241e-01 | 0.904 |
| R-HSA-9758941 | Gastrulation | 3.011823e-01 | 0.521 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.843075e-01 | 0.734 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 8.783208e-02 | 1.056 |
| R-HSA-199920 | CREB phosphorylation | 9.825706e-02 | 1.008 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.085635e-01 | 0.964 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.288263e-01 | 0.890 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 3.401793e-02 | 1.468 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.775013e-01 | 0.751 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.962051e-01 | 0.707 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.752722e-01 | 0.560 |
| R-HSA-429947 | Deadenylation of mRNA | 2.917639e-01 | 0.535 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.193971e-02 | 1.377 |
| R-HSA-5578775 | Ion homeostasis | 1.679654e-01 | 0.775 |
| R-HSA-68886 | M Phase | 4.441258e-02 | 1.352 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.679877e-01 | 0.775 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.144859e-01 | 0.669 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.411345e-01 | 0.618 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.158040e-01 | 0.501 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.236357e-01 | 0.490 |
| R-HSA-73894 | DNA Repair | 2.730176e-01 | 0.564 |
| R-HSA-446728 | Cell junction organization | 2.591948e-01 | 0.586 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.236357e-01 | 0.490 |
| R-HSA-9675135 | Diseases of DNA repair | 1.284438e-01 | 0.891 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.783208e-02 | 1.056 |
| R-HSA-164944 | Nef and signal transduction | 9.825706e-02 | 1.008 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 1.775013e-01 | 0.751 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 1.869067e-01 | 0.728 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.962051e-01 | 0.707 |
| R-HSA-174362 | Transport and metabolism of PAPS | 1.962051e-01 | 0.707 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.177739e-02 | 1.209 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.917639e-01 | 0.535 |
| R-HSA-69242 | S Phase | 4.377320e-02 | 1.359 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.635621e-01 | 0.786 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.158040e-01 | 0.501 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.063612e-01 | 0.514 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 6.194034e-02 | 1.208 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.144859e-01 | 0.669 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.931901e-02 | 1.307 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.577818e-01 | 0.589 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.288998e-01 | 0.890 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.719273e-01 | 0.765 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.288263e-01 | 0.890 |
| R-HSA-5578768 | Physiological factors | 1.869067e-01 | 0.728 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.835652e-01 | 0.547 |
| R-HSA-2160916 | Hyaluronan degradation | 2.998692e-01 | 0.523 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.078822e-01 | 0.512 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 2.260000e-01 | 0.646 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.936980e-01 | 0.532 |
| R-HSA-9830364 | Formation of the nephric duct | 5.004026e-02 | 1.301 |
| R-HSA-5688426 | Deubiquitination | 2.108991e-01 | 0.676 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.498160e-01 | 0.602 |
| R-HSA-5576891 | Cardiac conduction | 2.394484e-01 | 0.621 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.124180e-01 | 0.673 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.387852e-01 | 0.858 |
| R-HSA-9635465 | Suppression of apoptosis | 1.486309e-01 | 0.828 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 2.144859e-01 | 0.669 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.679654e-01 | 0.775 |
| R-HSA-74160 | Gene expression (Transcription) | 2.717627e-01 | 0.566 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.400624e-01 | 0.854 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.400624e-01 | 0.854 |
| R-HSA-2028269 | Signaling by Hippo | 2.234706e-01 | 0.651 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.835652e-01 | 0.547 |
| R-HSA-9909396 | Circadian clock | 2.424888e-01 | 0.615 |
| R-HSA-418360 | Platelet calcium homeostasis | 6.194034e-02 | 1.208 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 2.835652e-01 | 0.547 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.998692e-01 | 0.523 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.419036e-01 | 0.848 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.471140e-01 | 0.607 |
| R-HSA-68882 | Mitotic Anaphase | 1.373475e-01 | 0.862 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.615341e-02 | 1.118 |
| R-HSA-212436 | Generic Transcription Pathway | 2.667854e-01 | 0.574 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.390699e-01 | 0.857 |
| R-HSA-9707616 | Heme signaling | 1.925633e-01 | 0.715 |
| R-HSA-1483166 | Synthesis of PA | 3.974034e-02 | 1.401 |
| R-HSA-9607240 | FLT3 Signaling | 1.059749e-01 | 0.975 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 9.732121e-02 | 1.012 |
| R-HSA-69206 | G1/S Transition | 7.912958e-02 | 1.102 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.480261e-01 | 0.606 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.869067e-01 | 0.728 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.660703e-01 | 0.780 |
| R-HSA-109581 | Apoptosis | 5.794398e-02 | 1.237 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.288263e-01 | 0.890 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.962051e-01 | 0.707 |
| R-HSA-200425 | Carnitine shuttle | 2.835652e-01 | 0.547 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.943112e-02 | 1.306 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.947981e-01 | 0.710 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.361641e-01 | 0.866 |
| R-HSA-450294 | MAP kinase activation | 1.884290e-01 | 0.725 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.323531e-01 | 0.634 |
| R-HSA-6807070 | PTEN Regulation | 2.670209e-01 | 0.573 |
| R-HSA-448424 | Interleukin-17 signaling | 2.260000e-01 | 0.646 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.943112e-02 | 1.306 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.053978e-01 | 0.687 |
| R-HSA-727802 | Transport of nucleotide sugars | 2.411345e-01 | 0.618 |
| R-HSA-1181150 | Signaling by NODAL | 2.498160e-01 | 0.602 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.752722e-01 | 0.560 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 5.587769e-02 | 1.253 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.565423e-02 | 1.341 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.565881e-01 | 0.805 |
| R-HSA-2262752 | Cellular responses to stress | 5.435871e-02 | 1.265 |
| R-HSA-5357801 | Programmed Cell Death | 1.190508e-01 | 0.924 |
| R-HSA-9018682 | Biosynthesis of maresins | 2.835652e-01 | 0.547 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.886475e-02 | 1.103 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.322381e-01 | 0.879 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.752722e-01 | 0.560 |
| R-HSA-9757110 | Prednisone ADME | 3.236357e-01 | 0.490 |
| R-HSA-163685 | Integration of energy metabolism | 3.269760e-02 | 1.485 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.323531e-01 | 0.634 |
| R-HSA-3000170 | Syndecan interactions | 2.835652e-01 | 0.547 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.598194e-01 | 0.585 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.344326e-01 | 0.630 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.385984e-01 | 0.622 |
| R-HSA-9830369 | Kidney development | 2.133972e-01 | 0.671 |
| R-HSA-983712 | Ion channel transport | 2.182764e-01 | 0.661 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.386561e-01 | 0.622 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 9.518893e-02 | 1.021 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.835652e-01 | 0.547 |
| R-HSA-75153 | Apoptotic execution phase | 2.493671e-02 | 1.603 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.835652e-01 | 0.547 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 1.761059e-01 | 0.754 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.775013e-01 | 0.751 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.234706e-01 | 0.651 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.255208e-01 | 0.647 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.167982e-01 | 0.499 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 3.239186e-01 | 0.490 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.869067e-01 | 0.728 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.411345e-01 | 0.618 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 2.525823e-01 | 0.598 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.471140e-01 | 0.607 |
| R-HSA-1483257 | Phospholipid metabolism | 2.964459e-01 | 0.528 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.250370e-01 | 0.488 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.313781e-01 | 0.480 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.313781e-01 | 0.480 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.313781e-01 | 0.480 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.355561e-01 | 0.474 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.357231e-01 | 0.474 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.390324e-01 | 0.470 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.390324e-01 | 0.470 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.390324e-01 | 0.470 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.390324e-01 | 0.470 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.390324e-01 | 0.470 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.390324e-01 | 0.470 |
| R-HSA-8939211 | ESR-mediated signaling | 3.420492e-01 | 0.466 |
| R-HSA-1500931 | Cell-Cell communication | 3.435674e-01 | 0.464 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.440497e-01 | 0.463 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.465996e-01 | 0.460 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.465996e-01 | 0.460 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.465996e-01 | 0.460 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 3.465996e-01 | 0.460 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.482007e-01 | 0.458 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.540806e-01 | 0.451 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.540806e-01 | 0.451 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.540806e-01 | 0.451 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.540806e-01 | 0.451 |
| R-HSA-2024096 | HS-GAG degradation | 3.540806e-01 | 0.451 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.564762e-01 | 0.448 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.564762e-01 | 0.448 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.564762e-01 | 0.448 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.606001e-01 | 0.443 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.606001e-01 | 0.443 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.614764e-01 | 0.442 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.614764e-01 | 0.442 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.614764e-01 | 0.442 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.614764e-01 | 0.442 |
| R-HSA-9930044 | Nuclear RNA decay | 3.614764e-01 | 0.442 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.614764e-01 | 0.442 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.614764e-01 | 0.442 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.614764e-01 | 0.442 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.614764e-01 | 0.442 |
| R-HSA-9733709 | Cardiogenesis | 3.614764e-01 | 0.442 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.614764e-01 | 0.442 |
| R-HSA-8957322 | Metabolism of steroids | 3.616885e-01 | 0.442 |
| R-HSA-70171 | Glycolysis | 3.647144e-01 | 0.438 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.687879e-01 | 0.433 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.687879e-01 | 0.433 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.687879e-01 | 0.433 |
| R-HSA-2024101 | CS/DS degradation | 3.687879e-01 | 0.433 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.687879e-01 | 0.433 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.687879e-01 | 0.433 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 3.760162e-01 | 0.425 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.760162e-01 | 0.425 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.760162e-01 | 0.425 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.760162e-01 | 0.425 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.760162e-01 | 0.425 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.760162e-01 | 0.425 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.760696e-01 | 0.425 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.791699e-01 | 0.421 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.791699e-01 | 0.421 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.791699e-01 | 0.421 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.831622e-01 | 0.417 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.831622e-01 | 0.417 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.831622e-01 | 0.417 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.831622e-01 | 0.417 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.831622e-01 | 0.417 |
| R-HSA-169911 | Regulation of Apoptosis | 3.831622e-01 | 0.417 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.831622e-01 | 0.417 |
| R-HSA-168249 | Innate Immune System | 3.832723e-01 | 0.416 |
| R-HSA-162582 | Signal Transduction | 3.843956e-01 | 0.415 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.891791e-01 | 0.410 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.902267e-01 | 0.409 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.902267e-01 | 0.409 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.902267e-01 | 0.409 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.902267e-01 | 0.409 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.902267e-01 | 0.409 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.902267e-01 | 0.409 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.902267e-01 | 0.409 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.902267e-01 | 0.409 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.913081e-01 | 0.407 |
| R-HSA-418346 | Platelet homeostasis | 3.932172e-01 | 0.405 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.972108e-01 | 0.401 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.972108e-01 | 0.401 |
| R-HSA-4641258 | Degradation of DVL | 3.972108e-01 | 0.401 |
| R-HSA-4641257 | Degradation of AXIN | 3.972108e-01 | 0.401 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.972108e-01 | 0.401 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.972108e-01 | 0.401 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.972108e-01 | 0.401 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.012570e-01 | 0.397 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.041153e-01 | 0.393 |
| R-HSA-1566948 | Elastic fibre formation | 4.041153e-01 | 0.393 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.041153e-01 | 0.393 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.052583e-01 | 0.392 |
| R-HSA-202403 | TCR signaling | 4.092469e-01 | 0.388 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.092469e-01 | 0.388 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.092469e-01 | 0.388 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.109412e-01 | 0.386 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.109412e-01 | 0.386 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.109412e-01 | 0.386 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.109412e-01 | 0.386 |
| R-HSA-69541 | Stabilization of p53 | 4.109412e-01 | 0.386 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.176892e-01 | 0.379 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.176892e-01 | 0.379 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.176892e-01 | 0.379 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.176892e-01 | 0.379 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.176892e-01 | 0.379 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.211339e-01 | 0.376 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.243604e-01 | 0.372 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.243604e-01 | 0.372 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 4.243604e-01 | 0.372 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.243604e-01 | 0.372 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.243604e-01 | 0.372 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.243604e-01 | 0.372 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.243604e-01 | 0.372 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.243604e-01 | 0.372 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.243604e-01 | 0.372 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.309556e-01 | 0.366 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.309556e-01 | 0.366 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.309556e-01 | 0.366 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.309556e-01 | 0.366 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.309556e-01 | 0.366 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.309556e-01 | 0.366 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.309556e-01 | 0.366 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.309556e-01 | 0.366 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.328985e-01 | 0.364 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.328985e-01 | 0.364 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.367919e-01 | 0.360 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.374756e-01 | 0.359 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.439213e-01 | 0.353 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.439213e-01 | 0.353 |
| R-HSA-8854214 | TBC/RABGAPs | 4.439213e-01 | 0.353 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.439213e-01 | 0.353 |
| R-HSA-70326 | Glucose metabolism | 4.445353e-01 | 0.352 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.445353e-01 | 0.352 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.492924e-01 | 0.347 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.501803e-01 | 0.347 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.502935e-01 | 0.347 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.502935e-01 | 0.347 |
| R-HSA-9907900 | Proteasome assembly | 4.502935e-01 | 0.347 |
| R-HSA-373752 | Netrin-1 signaling | 4.502935e-01 | 0.347 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.522197e-01 | 0.345 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.522197e-01 | 0.345 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.522197e-01 | 0.345 |
| R-HSA-68875 | Mitotic Prophase | 4.560394e-01 | 0.341 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.565932e-01 | 0.340 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.565932e-01 | 0.340 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.565932e-01 | 0.340 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 4.565932e-01 | 0.340 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.565932e-01 | 0.340 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.565932e-01 | 0.340 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.565932e-01 | 0.340 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.565932e-01 | 0.340 |
| R-HSA-73886 | Chromosome Maintenance | 4.598438e-01 | 0.337 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.611848e-01 | 0.336 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.628210e-01 | 0.335 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.628210e-01 | 0.335 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.628210e-01 | 0.335 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.628210e-01 | 0.335 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.636328e-01 | 0.334 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.636328e-01 | 0.334 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.668875e-01 | 0.331 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.674063e-01 | 0.330 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.689778e-01 | 0.329 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.689778e-01 | 0.329 |
| R-HSA-437239 | Recycling pathway of L1 | 4.689778e-01 | 0.329 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.750644e-01 | 0.323 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.786322e-01 | 0.320 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.786322e-01 | 0.320 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.786322e-01 | 0.320 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.870302e-01 | 0.312 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.870302e-01 | 0.312 |
| R-HSA-109704 | PI3K Cascade | 4.870302e-01 | 0.312 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.897136e-01 | 0.310 |
| R-HSA-912446 | Meiotic recombination | 4.929110e-01 | 0.307 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.929110e-01 | 0.307 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.929110e-01 | 0.307 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.960222e-01 | 0.304 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.970193e-01 | 0.304 |
| R-HSA-72187 | mRNA 3'-end processing | 4.987248e-01 | 0.302 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.987248e-01 | 0.302 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.987248e-01 | 0.302 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.987248e-01 | 0.302 |
| R-HSA-397014 | Muscle contraction | 4.990408e-01 | 0.302 |
| R-HSA-1474165 | Reproduction | 5.006473e-01 | 0.300 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.044722e-01 | 0.297 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.044722e-01 | 0.297 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.044722e-01 | 0.297 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.101541e-01 | 0.292 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.101541e-01 | 0.292 |
| R-HSA-156588 | Glucuronidation | 5.101541e-01 | 0.292 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 5.157712e-01 | 0.288 |
| R-HSA-418990 | Adherens junctions interactions | 5.160609e-01 | 0.287 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.213242e-01 | 0.283 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.213242e-01 | 0.283 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.213242e-01 | 0.283 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.213242e-01 | 0.283 |
| R-HSA-177929 | Signaling by EGFR | 5.213242e-01 | 0.283 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.213242e-01 | 0.283 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.255700e-01 | 0.279 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.268139e-01 | 0.278 |
| R-HSA-112399 | IRS-mediated signalling | 5.268139e-01 | 0.278 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.322409e-01 | 0.274 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.322409e-01 | 0.274 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.325364e-01 | 0.274 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 5.376061e-01 | 0.270 |
| R-HSA-9033241 | Peroxisomal protein import | 5.376061e-01 | 0.270 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.376061e-01 | 0.270 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.376061e-01 | 0.270 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.382689e-01 | 0.269 |
| R-HSA-162906 | HIV Infection | 5.410043e-01 | 0.267 |
| R-HSA-1632852 | Macroautophagy | 5.428552e-01 | 0.265 |
| R-HSA-977443 | GABA receptor activation | 5.429100e-01 | 0.265 |
| R-HSA-351202 | Metabolism of polyamines | 5.429100e-01 | 0.265 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.481534e-01 | 0.261 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.481534e-01 | 0.261 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.481534e-01 | 0.261 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.481534e-01 | 0.261 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.530159e-01 | 0.257 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.533370e-01 | 0.257 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.533370e-01 | 0.257 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.533370e-01 | 0.257 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.533370e-01 | 0.257 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.533370e-01 | 0.257 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.563674e-01 | 0.255 |
| R-HSA-211981 | Xenobiotics | 5.635275e-01 | 0.249 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.635275e-01 | 0.249 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.635275e-01 | 0.249 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.685356e-01 | 0.245 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.685356e-01 | 0.245 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.695959e-01 | 0.244 |
| R-HSA-166520 | Signaling by NTRKs | 5.695959e-01 | 0.244 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.734866e-01 | 0.241 |
| R-HSA-1474244 | Extracellular matrix organization | 5.750558e-01 | 0.240 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.793299e-01 | 0.237 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.832197e-01 | 0.234 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.889026e-01 | 0.230 |
| R-HSA-73887 | Death Receptor Signaling | 5.889026e-01 | 0.230 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.927319e-01 | 0.227 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.937032e-01 | 0.226 |
| R-HSA-9612973 | Autophagy | 5.951947e-01 | 0.225 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.974067e-01 | 0.224 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.974067e-01 | 0.224 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.974067e-01 | 0.224 |
| R-HSA-3000178 | ECM proteoglycans | 5.974067e-01 | 0.224 |
| R-HSA-9711097 | Cellular response to starvation | 6.014150e-01 | 0.221 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.014150e-01 | 0.221 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.020281e-01 | 0.220 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.020281e-01 | 0.220 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.020281e-01 | 0.220 |
| R-HSA-421270 | Cell-cell junction organization | 6.037658e-01 | 0.219 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.065968e-01 | 0.217 |
| R-HSA-4086398 | Ca2+ pathway | 6.065968e-01 | 0.217 |
| R-HSA-9749641 | Aspirin ADME | 6.065968e-01 | 0.217 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.075634e-01 | 0.216 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.111133e-01 | 0.214 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.111133e-01 | 0.214 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 6.111133e-01 | 0.214 |
| R-HSA-449147 | Signaling by Interleukins | 6.150954e-01 | 0.211 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.155782e-01 | 0.211 |
| R-HSA-5619102 | SLC transporter disorders | 6.285181e-01 | 0.202 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.286694e-01 | 0.202 |
| R-HSA-5619084 | ABC transporter disorders | 6.286694e-01 | 0.202 |
| R-HSA-4086400 | PCP/CE pathway | 6.286694e-01 | 0.202 |
| R-HSA-9659379 | Sensory processing of sound | 6.329338e-01 | 0.199 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.371495e-01 | 0.196 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.371495e-01 | 0.196 |
| R-HSA-9833482 | PKR-mediated signaling | 6.371495e-01 | 0.196 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.413170e-01 | 0.193 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 6.413170e-01 | 0.193 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.429499e-01 | 0.192 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.446817e-01 | 0.191 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.454369e-01 | 0.190 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.455309e-01 | 0.190 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.495098e-01 | 0.187 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.513961e-01 | 0.186 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.535361e-01 | 0.185 |
| R-HSA-8953854 | Metabolism of RNA | 6.540528e-01 | 0.184 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.541761e-01 | 0.184 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.614513e-01 | 0.180 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.691866e-01 | 0.174 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.757868e-01 | 0.170 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.767461e-01 | 0.170 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.841337e-01 | 0.165 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.841337e-01 | 0.165 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.910115e-01 | 0.161 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.913534e-01 | 0.160 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.913534e-01 | 0.160 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.949015e-01 | 0.158 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.962932e-01 | 0.157 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.984090e-01 | 0.156 |
| R-HSA-1474290 | Collagen formation | 6.984090e-01 | 0.156 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.037037e-01 | 0.153 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.054163e-01 | 0.152 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.086926e-01 | 0.150 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.120424e-01 | 0.147 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.153539e-01 | 0.145 |
| R-HSA-190236 | Signaling by FGFR | 7.153539e-01 | 0.145 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.190887e-01 | 0.143 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.218636e-01 | 0.142 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.218636e-01 | 0.142 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.250408e-01 | 0.140 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.250408e-01 | 0.140 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.250627e-01 | 0.140 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.250627e-01 | 0.140 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.282253e-01 | 0.138 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.282253e-01 | 0.138 |
| R-HSA-1483255 | PI Metabolism | 7.282253e-01 | 0.138 |
| R-HSA-72172 | mRNA Splicing | 7.296034e-01 | 0.137 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.344422e-01 | 0.134 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.344422e-01 | 0.134 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.374974e-01 | 0.132 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.374974e-01 | 0.132 |
| R-HSA-69239 | Synthesis of DNA | 7.464548e-01 | 0.127 |
| R-HSA-211000 | Gene Silencing by RNA | 7.464548e-01 | 0.127 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.472194e-01 | 0.127 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.493725e-01 | 0.125 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.522568e-01 | 0.124 |
| R-HSA-168256 | Immune System | 7.534956e-01 | 0.123 |
| R-HSA-6803157 | Antimicrobial peptides | 7.579268e-01 | 0.120 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.634677e-01 | 0.117 |
| R-HSA-8951664 | Neddylation | 7.658576e-01 | 0.116 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.661907e-01 | 0.116 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.688825e-01 | 0.114 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.741739e-01 | 0.111 |
| R-HSA-373760 | L1CAM interactions | 7.767743e-01 | 0.110 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.793448e-01 | 0.108 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.793448e-01 | 0.108 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.795226e-01 | 0.108 |
| R-HSA-422475 | Axon guidance | 7.815992e-01 | 0.107 |
| R-HSA-3371556 | Cellular response to heat stress | 7.893360e-01 | 0.103 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.893360e-01 | 0.103 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.893360e-01 | 0.103 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.941616e-01 | 0.100 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.965330e-01 | 0.099 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.982558e-01 | 0.098 |
| R-HSA-194138 | Signaling by VEGF | 8.011945e-01 | 0.096 |
| R-HSA-157118 | Signaling by NOTCH | 8.013347e-01 | 0.096 |
| R-HSA-9843745 | Adipogenesis | 8.166890e-01 | 0.088 |
| R-HSA-9675108 | Nervous system development | 8.255297e-01 | 0.083 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.329312e-01 | 0.079 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.423471e-01 | 0.075 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.423471e-01 | 0.075 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 8.441660e-01 | 0.074 |
| R-HSA-913531 | Interferon Signaling | 8.451780e-01 | 0.073 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.563268e-01 | 0.067 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.566257e-01 | 0.067 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.596245e-01 | 0.066 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.596245e-01 | 0.066 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.596245e-01 | 0.066 |
| R-HSA-9609507 | Protein localization | 8.612451e-01 | 0.065 |
| R-HSA-69306 | DNA Replication | 8.612451e-01 | 0.065 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.644306e-01 | 0.063 |
| R-HSA-1989781 | PPARA activates gene expression | 8.644306e-01 | 0.063 |
| R-HSA-9610379 | HCMV Late Events | 8.675433e-01 | 0.062 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.675433e-01 | 0.062 |
| R-HSA-162587 | HIV Life Cycle | 8.675433e-01 | 0.062 |
| R-HSA-1280218 | Adaptive Immune System | 8.698294e-01 | 0.061 |
| R-HSA-195721 | Signaling by WNT | 8.819480e-01 | 0.055 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.820723e-01 | 0.054 |
| R-HSA-199991 | Membrane Trafficking | 8.860775e-01 | 0.053 |
| R-HSA-72306 | tRNA processing | 8.874297e-01 | 0.052 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.937873e-01 | 0.049 |
| R-HSA-168255 | Influenza Infection | 8.986152e-01 | 0.046 |
| R-HSA-3781865 | Diseases of glycosylation | 9.043442e-01 | 0.044 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.063745e-01 | 0.043 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.063745e-01 | 0.043 |
| R-HSA-9609690 | HCMV Early Events | 9.168138e-01 | 0.038 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.182235e-01 | 0.037 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.205999e-01 | 0.036 |
| R-HSA-6805567 | Keratinization | 9.268178e-01 | 0.033 |
| R-HSA-556833 | Metabolism of lipids | 9.360435e-01 | 0.029 |
| R-HSA-9748784 | Drug ADME | 9.363707e-01 | 0.029 |
| R-HSA-382551 | Transport of small molecules | 9.456627e-01 | 0.024 |
| R-HSA-15869 | Metabolism of nucleotides | 9.484238e-01 | 0.023 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.501991e-01 | 0.022 |
| R-HSA-1266738 | Developmental Biology | 9.504404e-01 | 0.022 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.510731e-01 | 0.022 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.542966e-01 | 0.020 |
| R-HSA-9609646 | HCMV Infection | 9.562037e-01 | 0.019 |
| R-HSA-109582 | Hemostasis | 9.566940e-01 | 0.019 |
| R-HSA-8978868 | Fatty acid metabolism | 9.585530e-01 | 0.018 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.623780e-01 | 0.017 |
| R-HSA-416476 | G alpha (q) signalling events | 9.628154e-01 | 0.016 |
| R-HSA-9679506 | SARS-CoV Infections | 9.629508e-01 | 0.016 |
| R-HSA-5668914 | Diseases of metabolism | 9.659593e-01 | 0.015 |
| R-HSA-72766 | Translation | 9.666260e-01 | 0.015 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.669206e-01 | 0.015 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.684335e-01 | 0.014 |
| R-HSA-597592 | Post-translational protein modification | 9.760318e-01 | 0.011 |
| R-HSA-112316 | Neuronal System | 9.773806e-01 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 9.827269e-01 | 0.008 |
| R-HSA-211859 | Biological oxidations | 9.870558e-01 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 9.916347e-01 | 0.004 |
| R-HSA-9824446 | Viral Infection Pathways | 9.974582e-01 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 9.984823e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.994418e-01 | 0.000 |
| R-HSA-1643685 | Disease | 9.996393e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.997186e-01 | 0.000 |
| R-HSA-5663205 | Infectious disease | 9.998160e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999997e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.868 | 0.065 | 2 | 0.900 |
NLK |
0.866 | 0.290 | 1 | 0.902 |
CLK3 |
0.864 | 0.226 | 1 | 0.885 |
CDC7 |
0.863 | 0.068 | 1 | 0.825 |
NDR2 |
0.861 | 0.082 | -3 | 0.812 |
PIM3 |
0.860 | 0.085 | -3 | 0.808 |
MTOR |
0.860 | 0.079 | 1 | 0.814 |
MST4 |
0.859 | 0.160 | 2 | 0.900 |
PKN3 |
0.858 | 0.089 | -3 | 0.796 |
NUAK2 |
0.857 | 0.101 | -3 | 0.816 |
NDR1 |
0.857 | 0.093 | -3 | 0.812 |
PRPK |
0.857 | -0.046 | -1 | 0.843 |
ULK2 |
0.856 | 0.005 | 2 | 0.834 |
SRPK1 |
0.856 | 0.156 | -3 | 0.720 |
PIM1 |
0.856 | 0.137 | -3 | 0.767 |
RAF1 |
0.856 | -0.017 | 1 | 0.819 |
CDKL1 |
0.856 | 0.091 | -3 | 0.773 |
GCN2 |
0.855 | -0.032 | 2 | 0.840 |
HIPK4 |
0.855 | 0.184 | 1 | 0.856 |
PRKD1 |
0.855 | 0.083 | -3 | 0.798 |
CDKL5 |
0.855 | 0.109 | -3 | 0.765 |
ERK5 |
0.855 | 0.136 | 1 | 0.817 |
CDK8 |
0.855 | 0.256 | 1 | 0.812 |
CAMK1B |
0.855 | 0.043 | -3 | 0.838 |
RSK2 |
0.855 | 0.103 | -3 | 0.743 |
KIS |
0.855 | 0.214 | 1 | 0.834 |
AMPKA1 |
0.854 | 0.104 | -3 | 0.832 |
MOS |
0.854 | 0.038 | 1 | 0.861 |
PRKD2 |
0.854 | 0.099 | -3 | 0.750 |
PKCD |
0.854 | 0.133 | 2 | 0.849 |
WNK1 |
0.854 | 0.089 | -2 | 0.905 |
RSK3 |
0.853 | 0.097 | -3 | 0.731 |
P90RSK |
0.853 | 0.083 | -3 | 0.742 |
PKN2 |
0.853 | 0.095 | -3 | 0.823 |
CDK7 |
0.853 | 0.250 | 1 | 0.817 |
TBK1 |
0.853 | -0.054 | 1 | 0.739 |
NEK6 |
0.852 | 0.057 | -2 | 0.869 |
CDK19 |
0.852 | 0.258 | 1 | 0.779 |
PDHK4 |
0.852 | -0.179 | 1 | 0.846 |
AMPKA2 |
0.852 | 0.105 | -3 | 0.801 |
CDK5 |
0.851 | 0.285 | 1 | 0.822 |
SRPK2 |
0.851 | 0.143 | -3 | 0.648 |
PDHK1 |
0.851 | -0.082 | 1 | 0.836 |
NIK |
0.851 | 0.071 | -3 | 0.859 |
MARK4 |
0.851 | 0.065 | 4 | 0.868 |
P70S6KB |
0.850 | 0.113 | -3 | 0.774 |
ICK |
0.850 | 0.143 | -3 | 0.809 |
ATR |
0.849 | 0.004 | 1 | 0.833 |
PKACG |
0.848 | 0.078 | -2 | 0.780 |
NEK7 |
0.848 | -0.021 | -3 | 0.842 |
MAPKAPK3 |
0.848 | 0.040 | -3 | 0.761 |
NIM1 |
0.848 | 0.058 | 3 | 0.754 |
CDK18 |
0.848 | 0.274 | 1 | 0.752 |
BMPR2 |
0.848 | -0.137 | -2 | 0.878 |
DSTYK |
0.847 | -0.057 | 2 | 0.902 |
IKKB |
0.847 | -0.113 | -2 | 0.766 |
TSSK1 |
0.847 | 0.079 | -3 | 0.842 |
IKKE |
0.847 | -0.095 | 1 | 0.731 |
NEK9 |
0.846 | 0.033 | 2 | 0.888 |
CAMLCK |
0.846 | 0.029 | -2 | 0.866 |
CDK13 |
0.846 | 0.241 | 1 | 0.795 |
CAMK2G |
0.846 | -0.083 | 2 | 0.828 |
JNK2 |
0.846 | 0.307 | 1 | 0.774 |
NUAK1 |
0.846 | 0.051 | -3 | 0.768 |
LATS2 |
0.845 | 0.004 | -5 | 0.737 |
AURC |
0.845 | 0.089 | -2 | 0.675 |
CAMK2D |
0.845 | 0.006 | -3 | 0.819 |
CHAK2 |
0.844 | -0.010 | -1 | 0.814 |
RIPK3 |
0.844 | -0.074 | 3 | 0.720 |
MNK2 |
0.844 | 0.074 | -2 | 0.827 |
WNK3 |
0.844 | -0.094 | 1 | 0.797 |
PKCB |
0.844 | 0.102 | 2 | 0.806 |
TGFBR2 |
0.843 | -0.044 | -2 | 0.744 |
DAPK2 |
0.843 | 0.017 | -3 | 0.839 |
TSSK2 |
0.843 | 0.031 | -5 | 0.825 |
MLK1 |
0.843 | -0.056 | 2 | 0.858 |
DYRK2 |
0.843 | 0.234 | 1 | 0.811 |
BCKDK |
0.843 | -0.099 | -1 | 0.824 |
MELK |
0.843 | 0.048 | -3 | 0.786 |
SKMLCK |
0.842 | -0.008 | -2 | 0.873 |
CLK1 |
0.842 | 0.174 | -3 | 0.722 |
IRE1 |
0.842 | 0.006 | 1 | 0.760 |
CDK9 |
0.842 | 0.238 | 1 | 0.798 |
MLK2 |
0.842 | 0.008 | 2 | 0.866 |
SGK3 |
0.842 | 0.136 | -3 | 0.740 |
PKCA |
0.842 | 0.110 | 2 | 0.796 |
PKCG |
0.841 | 0.079 | 2 | 0.808 |
HUNK |
0.841 | -0.083 | 2 | 0.818 |
ULK1 |
0.841 | -0.114 | -3 | 0.819 |
CDK1 |
0.841 | 0.243 | 1 | 0.768 |
MAPKAPK2 |
0.841 | 0.032 | -3 | 0.720 |
P38A |
0.840 | 0.261 | 1 | 0.814 |
JNK3 |
0.840 | 0.270 | 1 | 0.801 |
CDK16 |
0.840 | 0.298 | 1 | 0.723 |
CDK17 |
0.840 | 0.260 | 1 | 0.707 |
PHKG1 |
0.840 | 0.040 | -3 | 0.806 |
SRPK3 |
0.840 | 0.097 | -3 | 0.692 |
HIPK1 |
0.840 | 0.249 | 1 | 0.825 |
PRKD3 |
0.840 | 0.046 | -3 | 0.717 |
RSK4 |
0.839 | 0.103 | -3 | 0.709 |
QIK |
0.839 | 0.007 | -3 | 0.812 |
CDK10 |
0.839 | 0.293 | 1 | 0.779 |
P38G |
0.839 | 0.281 | 1 | 0.701 |
IRE2 |
0.839 | 0.023 | 2 | 0.808 |
CLK4 |
0.839 | 0.138 | -3 | 0.745 |
PIM2 |
0.839 | 0.137 | -3 | 0.724 |
SIK |
0.839 | 0.052 | -3 | 0.745 |
CDK12 |
0.839 | 0.238 | 1 | 0.775 |
MASTL |
0.839 | -0.165 | -2 | 0.842 |
QSK |
0.839 | 0.050 | 4 | 0.851 |
PAK3 |
0.839 | 0.014 | -2 | 0.798 |
MNK1 |
0.839 | 0.071 | -2 | 0.835 |
PAK1 |
0.838 | 0.033 | -2 | 0.793 |
CAMK4 |
0.838 | -0.029 | -3 | 0.803 |
GRK5 |
0.838 | -0.167 | -3 | 0.846 |
HIPK2 |
0.838 | 0.255 | 1 | 0.752 |
PKCZ |
0.838 | 0.046 | 2 | 0.843 |
NEK2 |
0.838 | 0.052 | 2 | 0.870 |
ERK1 |
0.837 | 0.252 | 1 | 0.760 |
PKCH |
0.837 | 0.070 | 2 | 0.786 |
PKACB |
0.837 | 0.086 | -2 | 0.701 |
AKT2 |
0.836 | 0.090 | -3 | 0.664 |
PKG2 |
0.836 | 0.081 | -2 | 0.712 |
PKR |
0.836 | 0.081 | 1 | 0.814 |
CDK14 |
0.836 | 0.261 | 1 | 0.787 |
IKKA |
0.836 | -0.074 | -2 | 0.755 |
CDK2 |
0.836 | 0.167 | 1 | 0.814 |
PAK6 |
0.836 | 0.071 | -2 | 0.727 |
P38B |
0.835 | 0.255 | 1 | 0.758 |
MSK2 |
0.835 | -0.012 | -3 | 0.718 |
CDK3 |
0.835 | 0.241 | 1 | 0.722 |
CHK1 |
0.834 | 0.017 | -3 | 0.805 |
MLK3 |
0.834 | -0.002 | 2 | 0.809 |
AURB |
0.834 | 0.054 | -2 | 0.675 |
ANKRD3 |
0.834 | -0.098 | 1 | 0.843 |
DYRK1A |
0.834 | 0.188 | 1 | 0.859 |
CLK2 |
0.834 | 0.186 | -3 | 0.722 |
RIPK1 |
0.833 | -0.150 | 1 | 0.793 |
CHAK1 |
0.833 | -0.027 | 2 | 0.840 |
ERK2 |
0.832 | 0.219 | 1 | 0.792 |
BRSK2 |
0.832 | -0.012 | -3 | 0.795 |
MARK3 |
0.832 | 0.055 | 4 | 0.825 |
CAMK2B |
0.832 | -0.010 | 2 | 0.782 |
TTBK2 |
0.831 | -0.129 | 2 | 0.783 |
GRK6 |
0.831 | -0.118 | 1 | 0.798 |
BRSK1 |
0.831 | -0.009 | -3 | 0.766 |
ATM |
0.831 | -0.035 | 1 | 0.779 |
DCAMKL1 |
0.831 | 0.061 | -3 | 0.765 |
HIPK3 |
0.831 | 0.206 | 1 | 0.828 |
LATS1 |
0.831 | 0.002 | -3 | 0.818 |
PRKX |
0.831 | 0.093 | -3 | 0.658 |
AKT1 |
0.831 | 0.099 | -3 | 0.685 |
MARK2 |
0.831 | 0.040 | 4 | 0.783 |
DLK |
0.831 | -0.198 | 1 | 0.808 |
DNAPK |
0.830 | 0.034 | 1 | 0.730 |
VRK2 |
0.830 | -0.000 | 1 | 0.868 |
PKCT |
0.830 | 0.071 | 2 | 0.797 |
MEK1 |
0.829 | -0.091 | 2 | 0.851 |
P70S6K |
0.828 | 0.095 | -3 | 0.687 |
PAK2 |
0.828 | -0.019 | -2 | 0.777 |
PHKG2 |
0.828 | 0.041 | -3 | 0.777 |
YSK4 |
0.828 | -0.070 | 1 | 0.756 |
GRK1 |
0.828 | -0.057 | -2 | 0.757 |
DYRK1B |
0.828 | 0.219 | 1 | 0.783 |
CAMK2A |
0.828 | -0.030 | 2 | 0.803 |
MSK1 |
0.828 | 0.009 | -3 | 0.726 |
P38D |
0.827 | 0.262 | 1 | 0.735 |
IRAK4 |
0.827 | 0.009 | 1 | 0.772 |
MYLK4 |
0.827 | -0.007 | -2 | 0.781 |
WNK4 |
0.826 | 0.005 | -2 | 0.905 |
CAMK1G |
0.826 | 0.002 | -3 | 0.739 |
MST3 |
0.826 | 0.106 | 2 | 0.882 |
ALK4 |
0.826 | -0.071 | -2 | 0.781 |
FAM20C |
0.826 | -0.024 | 2 | 0.575 |
DYRK3 |
0.826 | 0.184 | 1 | 0.822 |
CDK6 |
0.825 | 0.258 | 1 | 0.777 |
MLK4 |
0.825 | -0.065 | 2 | 0.779 |
MPSK1 |
0.825 | 0.134 | 1 | 0.779 |
PLK1 |
0.825 | -0.095 | -2 | 0.807 |
SMG1 |
0.825 | -0.053 | 1 | 0.786 |
CDK4 |
0.824 | 0.260 | 1 | 0.763 |
MARK1 |
0.824 | -0.004 | 4 | 0.843 |
PRP4 |
0.824 | 0.103 | -3 | 0.725 |
MEKK1 |
0.824 | -0.029 | 1 | 0.810 |
PKCI |
0.824 | 0.059 | 2 | 0.812 |
PLK4 |
0.824 | -0.056 | 2 | 0.653 |
SNRK |
0.823 | -0.121 | 2 | 0.699 |
DYRK4 |
0.823 | 0.216 | 1 | 0.766 |
SSTK |
0.823 | 0.040 | 4 | 0.841 |
GRK4 |
0.823 | -0.198 | -2 | 0.797 |
ZAK |
0.823 | -0.024 | 1 | 0.775 |
HRI |
0.823 | -0.076 | -2 | 0.832 |
AURA |
0.823 | 0.014 | -2 | 0.635 |
PKACA |
0.823 | 0.058 | -2 | 0.652 |
BRAF |
0.822 | -0.022 | -4 | 0.818 |
NEK5 |
0.822 | 0.010 | 1 | 0.804 |
DCAMKL2 |
0.821 | 0.010 | -3 | 0.787 |
PERK |
0.821 | -0.045 | -2 | 0.807 |
BMPR1B |
0.821 | -0.030 | 1 | 0.736 |
TAO3 |
0.821 | 0.051 | 1 | 0.788 |
TGFBR1 |
0.821 | -0.059 | -2 | 0.743 |
MAPKAPK5 |
0.821 | -0.097 | -3 | 0.701 |
PKN1 |
0.820 | 0.056 | -3 | 0.704 |
PKCE |
0.820 | 0.087 | 2 | 0.794 |
SGK1 |
0.820 | 0.113 | -3 | 0.589 |
TLK2 |
0.820 | -0.077 | 1 | 0.778 |
PINK1 |
0.820 | -0.049 | 1 | 0.856 |
ERK7 |
0.820 | 0.133 | 2 | 0.605 |
DRAK1 |
0.819 | -0.084 | 1 | 0.735 |
AKT3 |
0.819 | 0.090 | -3 | 0.605 |
MEK5 |
0.819 | -0.138 | 2 | 0.855 |
MEKK2 |
0.818 | -0.056 | 2 | 0.849 |
PLK3 |
0.817 | -0.101 | 2 | 0.781 |
MOK |
0.817 | 0.207 | 1 | 0.793 |
CK1E |
0.817 | 0.002 | -3 | 0.574 |
TAO2 |
0.817 | 0.039 | 2 | 0.896 |
SMMLCK |
0.817 | -0.012 | -3 | 0.791 |
CAMK1D |
0.816 | 0.011 | -3 | 0.663 |
MAK |
0.816 | 0.203 | -2 | 0.749 |
GRK7 |
0.815 | -0.065 | 1 | 0.735 |
PAK5 |
0.815 | 0.015 | -2 | 0.654 |
NEK4 |
0.815 | 0.047 | 1 | 0.772 |
ACVR2A |
0.814 | -0.103 | -2 | 0.737 |
ROCK2 |
0.814 | 0.138 | -3 | 0.767 |
MRCKB |
0.813 | 0.100 | -3 | 0.717 |
MRCKA |
0.813 | 0.106 | -3 | 0.736 |
ALK2 |
0.813 | -0.098 | -2 | 0.753 |
LKB1 |
0.813 | 0.037 | -3 | 0.814 |
ACVR2B |
0.813 | -0.109 | -2 | 0.753 |
MEKK3 |
0.812 | -0.171 | 1 | 0.783 |
NEK11 |
0.812 | -0.069 | 1 | 0.796 |
HGK |
0.812 | 0.047 | 3 | 0.825 |
TNIK |
0.812 | 0.080 | 3 | 0.824 |
JNK1 |
0.811 | 0.198 | 1 | 0.755 |
CAMKK1 |
0.811 | -0.063 | -2 | 0.795 |
PAK4 |
0.811 | 0.009 | -2 | 0.657 |
GAK |
0.810 | 0.035 | 1 | 0.813 |
IRAK1 |
0.810 | -0.167 | -1 | 0.764 |
LOK |
0.810 | 0.050 | -2 | 0.818 |
PDK1 |
0.810 | -0.012 | 1 | 0.815 |
NEK8 |
0.810 | -0.077 | 2 | 0.865 |
GSK3A |
0.809 | 0.034 | 4 | 0.428 |
DAPK3 |
0.809 | 0.024 | -3 | 0.776 |
MINK |
0.809 | 0.032 | 1 | 0.770 |
TLK1 |
0.809 | -0.143 | -2 | 0.788 |
NEK1 |
0.809 | 0.075 | 1 | 0.777 |
KHS1 |
0.808 | 0.089 | 1 | 0.761 |
MEKK6 |
0.808 | 0.012 | 1 | 0.762 |
CAMK1A |
0.808 | 0.022 | -3 | 0.639 |
CK1G1 |
0.808 | -0.026 | -3 | 0.566 |
MAP3K15 |
0.808 | 0.009 | 1 | 0.764 |
GCK |
0.808 | 0.001 | 1 | 0.773 |
CAMKK2 |
0.807 | -0.053 | -2 | 0.795 |
TTBK1 |
0.807 | -0.127 | 2 | 0.702 |
EEF2K |
0.807 | 0.010 | 3 | 0.802 |
GSK3B |
0.807 | -0.027 | 4 | 0.420 |
YSK1 |
0.806 | 0.076 | 2 | 0.869 |
HPK1 |
0.806 | 0.022 | 1 | 0.762 |
LRRK2 |
0.806 | -0.024 | 2 | 0.887 |
KHS2 |
0.806 | 0.090 | 1 | 0.771 |
GRK2 |
0.805 | -0.141 | -2 | 0.684 |
CHK2 |
0.805 | -0.004 | -3 | 0.618 |
SBK |
0.804 | 0.037 | -3 | 0.553 |
CK1D |
0.803 | -0.023 | -3 | 0.532 |
BMPR1A |
0.803 | -0.061 | 1 | 0.726 |
NEK3 |
0.803 | 0.042 | 1 | 0.762 |
PBK |
0.803 | 0.068 | 1 | 0.737 |
PASK |
0.803 | -0.103 | -3 | 0.819 |
DMPK1 |
0.802 | 0.108 | -3 | 0.741 |
CRIK |
0.802 | 0.136 | -3 | 0.685 |
MST2 |
0.802 | -0.071 | 1 | 0.783 |
ROCK1 |
0.802 | 0.108 | -3 | 0.736 |
VRK1 |
0.801 | -0.014 | 2 | 0.866 |
BUB1 |
0.801 | 0.039 | -5 | 0.743 |
DAPK1 |
0.801 | -0.004 | -3 | 0.754 |
CK1A2 |
0.800 | -0.026 | -3 | 0.530 |
TAK1 |
0.799 | -0.063 | 1 | 0.811 |
MST1 |
0.797 | -0.056 | 1 | 0.765 |
PKG1 |
0.797 | 0.017 | -2 | 0.627 |
SLK |
0.796 | -0.070 | -2 | 0.749 |
STK33 |
0.796 | -0.106 | 2 | 0.671 |
MEK2 |
0.795 | -0.120 | 2 | 0.837 |
RIPK2 |
0.794 | -0.186 | 1 | 0.757 |
HASPIN |
0.792 | 0.020 | -1 | 0.669 |
CK2A2 |
0.791 | -0.032 | 1 | 0.684 |
PDHK3_TYR |
0.790 | 0.149 | 4 | 0.875 |
MYO3B |
0.790 | 0.042 | 2 | 0.885 |
TAO1 |
0.789 | 0.004 | 1 | 0.731 |
BIKE |
0.788 | 0.047 | 1 | 0.699 |
GRK3 |
0.787 | -0.144 | -2 | 0.627 |
OSR1 |
0.786 | -0.037 | 2 | 0.840 |
PLK2 |
0.785 | -0.096 | -3 | 0.753 |
LIMK2_TYR |
0.785 | 0.136 | -3 | 0.874 |
TESK1_TYR |
0.785 | 0.044 | 3 | 0.843 |
TTK |
0.784 | -0.060 | -2 | 0.792 |
PKMYT1_TYR |
0.783 | 0.083 | 3 | 0.820 |
MYO3A |
0.783 | -0.013 | 1 | 0.764 |
ASK1 |
0.782 | -0.066 | 1 | 0.759 |
CK2A1 |
0.780 | -0.049 | 1 | 0.659 |
PDHK4_TYR |
0.779 | -0.007 | 2 | 0.884 |
MAP2K4_TYR |
0.779 | -0.064 | -1 | 0.873 |
MAP2K7_TYR |
0.777 | -0.147 | 2 | 0.877 |
AAK1 |
0.777 | 0.089 | 1 | 0.601 |
PINK1_TYR |
0.776 | -0.098 | 1 | 0.827 |
LIMK1_TYR |
0.776 | -0.019 | 2 | 0.890 |
TNNI3K_TYR |
0.776 | 0.139 | 1 | 0.808 |
MAP2K6_TYR |
0.775 | -0.103 | -1 | 0.877 |
TYK2 |
0.773 | -0.041 | 1 | 0.788 |
RET |
0.772 | -0.061 | 1 | 0.790 |
ROS1 |
0.771 | -0.049 | 3 | 0.755 |
YANK3 |
0.771 | -0.065 | 2 | 0.457 |
BMPR2_TYR |
0.770 | -0.098 | -1 | 0.835 |
PDHK1_TYR |
0.769 | -0.156 | -1 | 0.856 |
JAK2 |
0.768 | -0.082 | 1 | 0.794 |
TYRO3 |
0.767 | -0.121 | 3 | 0.773 |
MST1R |
0.767 | -0.118 | 3 | 0.772 |
NEK10_TYR |
0.767 | 0.005 | 1 | 0.689 |
ALPHAK3 |
0.766 | -0.144 | -1 | 0.756 |
STLK3 |
0.766 | -0.153 | 1 | 0.746 |
DDR1 |
0.764 | -0.143 | 4 | 0.807 |
EPHA6 |
0.763 | -0.084 | -1 | 0.799 |
CSF1R |
0.763 | -0.122 | 3 | 0.742 |
TNK1 |
0.763 | -0.032 | 3 | 0.756 |
JAK1 |
0.763 | 0.010 | 1 | 0.744 |
CK1A |
0.762 | -0.065 | -3 | 0.445 |
ABL2 |
0.761 | -0.052 | -1 | 0.772 |
JAK3 |
0.761 | -0.119 | 1 | 0.777 |
EPHB4 |
0.760 | -0.127 | -1 | 0.791 |
FGR |
0.759 | -0.134 | 1 | 0.789 |
ABL1 |
0.759 | -0.059 | -1 | 0.767 |
PDGFRB |
0.757 | -0.149 | 3 | 0.764 |
YES1 |
0.757 | -0.123 | -1 | 0.789 |
TXK |
0.757 | -0.045 | 1 | 0.782 |
INSRR |
0.756 | -0.155 | 3 | 0.715 |
TNK2 |
0.756 | -0.124 | 3 | 0.701 |
ITK |
0.754 | -0.110 | -1 | 0.755 |
FER |
0.754 | -0.218 | 1 | 0.816 |
KDR |
0.754 | -0.131 | 3 | 0.703 |
HCK |
0.753 | -0.143 | -1 | 0.763 |
LCK |
0.753 | -0.080 | -1 | 0.752 |
FLT3 |
0.753 | -0.160 | 3 | 0.759 |
FGFR1 |
0.752 | -0.160 | 3 | 0.728 |
TEK |
0.752 | -0.162 | 3 | 0.699 |
PDGFRA |
0.752 | -0.182 | 3 | 0.763 |
FGFR2 |
0.752 | -0.191 | 3 | 0.741 |
AXL |
0.751 | -0.161 | 3 | 0.729 |
WEE1_TYR |
0.750 | -0.094 | -1 | 0.720 |
EPHB1 |
0.749 | -0.174 | 1 | 0.796 |
BLK |
0.749 | -0.071 | -1 | 0.760 |
EPHB3 |
0.748 | -0.161 | -1 | 0.773 |
KIT |
0.748 | -0.208 | 3 | 0.738 |
DDR2 |
0.748 | -0.062 | 3 | 0.687 |
EPHA4 |
0.747 | -0.146 | 2 | 0.767 |
SRMS |
0.747 | -0.202 | 1 | 0.794 |
ALK |
0.747 | -0.175 | 3 | 0.688 |
MERTK |
0.746 | -0.177 | 3 | 0.725 |
BTK |
0.746 | -0.214 | -1 | 0.723 |
PTK6 |
0.745 | -0.189 | -1 | 0.710 |
TEC |
0.745 | -0.144 | -1 | 0.690 |
BMX |
0.744 | -0.124 | -1 | 0.658 |
EPHB2 |
0.744 | -0.174 | -1 | 0.755 |
LTK |
0.743 | -0.183 | 3 | 0.704 |
INSR |
0.743 | -0.173 | 3 | 0.705 |
MET |
0.743 | -0.193 | 3 | 0.731 |
NTRK2 |
0.739 | -0.244 | 3 | 0.715 |
NTRK1 |
0.739 | -0.259 | -1 | 0.794 |
FLT4 |
0.739 | -0.207 | 3 | 0.710 |
CK1G3 |
0.739 | -0.088 | -3 | 0.398 |
EPHA1 |
0.739 | -0.192 | 3 | 0.708 |
FLT1 |
0.738 | -0.207 | -1 | 0.787 |
FGFR3 |
0.737 | -0.227 | 3 | 0.711 |
EPHA7 |
0.736 | -0.178 | 2 | 0.779 |
YANK2 |
0.736 | -0.094 | 2 | 0.470 |
FRK |
0.736 | -0.192 | -1 | 0.763 |
LYN |
0.735 | -0.182 | 3 | 0.691 |
FYN |
0.735 | -0.135 | -1 | 0.720 |
ERBB2 |
0.735 | -0.253 | 1 | 0.729 |
EPHA3 |
0.734 | -0.217 | 2 | 0.750 |
NTRK3 |
0.733 | -0.222 | -1 | 0.747 |
MATK |
0.731 | -0.186 | -1 | 0.692 |
PTK2B |
0.730 | -0.171 | -1 | 0.730 |
CSK |
0.726 | -0.220 | 2 | 0.790 |
EPHA5 |
0.725 | -0.212 | 2 | 0.743 |
EGFR |
0.725 | -0.174 | 1 | 0.644 |
SRC |
0.725 | -0.205 | -1 | 0.730 |
EPHA8 |
0.724 | -0.201 | -1 | 0.743 |
MUSK |
0.724 | -0.180 | 1 | 0.622 |
IGF1R |
0.721 | -0.209 | 3 | 0.647 |
PTK2 |
0.719 | -0.117 | -1 | 0.727 |
FGFR4 |
0.719 | -0.216 | -1 | 0.727 |
SYK |
0.714 | -0.153 | -1 | 0.711 |
EPHA2 |
0.712 | -0.216 | -1 | 0.711 |
CK1G2 |
0.708 | -0.131 | -3 | 0.487 |
ERBB4 |
0.708 | -0.185 | 1 | 0.649 |
FES |
0.700 | -0.257 | -1 | 0.643 |
ZAP70 |
0.697 | -0.146 | -1 | 0.654 |