Motif 78 (n=104)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JS52 | None | S41 | ochoa | Myelin transcription factor 1 domain-containing protein | None |
| A8K0R7 | ZNF839 | S348 | ochoa | Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) | None |
| O00213 | APBB1 | S287 | psp | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) | Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347). {ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:36250347}. |
| O00562 | PITPNM1 | S621 | ochoa|psp | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| O15055 | PER2 | S977 | ochoa | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15417 | TNRC18 | S263 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43314 | PPIP5K2 | S1108 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43379 | WDR62 | S33 | ochoa|psp | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O60256 | PRPSAP2 | S227 | ochoa | Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41) | Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. |
| O75369 | FLNB | S2325 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1263 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S1322 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75534 | CSDE1 | S514 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O95359 | TACC2 | S962 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95994 | AGR2 | S146 | ochoa | Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) | Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}. |
| P0DPH7 | TUBA3C | S379 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S379 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P12883 | MYH7 | S1288 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P19484 | TFEB | S423 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P21333 | FLNA | S2370 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21731 | TBXA2R | S324 | psp | Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 1]: Activates adenylyl cyclase. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 2]: Inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}. |
| P25054 | APC | S1042 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P28715 | ERCC5 | S384 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P33076 | CIITA | S834 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P35548 | MSX2 | S123 | ochoa | Homeobox protein MSX-2 (Homeobox protein Hox-8) | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
| P43405 | SYK | S350 | ochoa | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P46087 | NOP2 | S44 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46777 | RPL5 | S172 | ochoa | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P49023 | PXN | S303 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49703 | ARL4D | S144 | psp | ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L) | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. {ECO:0000269|PubMed:17398095}. |
| P68363 | TUBA1B | S379 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S379 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P86790 | CCZ1B | S266 | ochoa | Vacuolar fusion protein CCZ1 homolog B (Vacuolar fusion protein CCZ1 homolog-like) | None |
| P86791 | CCZ1 | S266 | ochoa | Vacuolar fusion protein CCZ1 homolog | Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000269|PubMed:23084991}. |
| Q01082 | SPTBN1 | S825 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01538 | MYT1 | S333 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
| Q05D32 | CTDSPL2 | S165 | ochoa | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q12778 | FOXO1 | S329 | ochoa|psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q13428 | TCOF1 | S1257 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14558 | PRPSAP1 | S215 | ochoa | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. |
| Q15149 | PLEC | S3461 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q16584 | MAP3K11 | S548 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q5PRF9 | SAMD4B | S592 | ochoa|psp | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5T0Z8 | C6orf132 | S1010 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T1R4 | HIVEP3 | S2245 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q66K64 | DCAF15 | S373 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
| Q68DQ2 | CRYBG3 | S716 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q69YU3 | ANKRD34A | S400 | ochoa | Ankyrin repeat domain-containing protein 34A | None |
| Q6KC79 | NIPBL | S228 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NUN9 | ZNF746 | S359 | ochoa | Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}. |
| Q6PIF6 | MYO7B | S934 | ochoa | Unconventional myosin-VIIb | Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length (PubMed:24725409, PubMed:26812018, PubMed:32209652). May link the complex to the actin core bundle of microvilli. {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018, ECO:0000269|PubMed:32209652, ECO:0000305|PubMed:24725409, ECO:0000305|PubMed:26812018}. |
| Q71U36 | TUBA1A | S379 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7RTP6 | MICAL3 | S1512 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q86TC9 | MYPN | S101 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86YR5 | GPSM1 | S486 | ochoa | G-protein-signaling modulator 1 (Activator of G-protein signaling 3) | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}. |
| Q86YV5 | PRAG1 | S463 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IZ73 | RPUSD2 | S436 | ochoa | Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}. |
| Q8N8Z6 | DCBLD1 | S640 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8N9T8 | KRI1 | S628 | ochoa | Protein KRI1 homolog | None |
| Q8NHM5 | KDM2B | S445 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8TAD8 | SNIP1 | S35 | ochoa|psp | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TBE0 | BAHD1 | S405 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TC05 | MDM1 | S683 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TD16 | BICD2 | S574 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TD16 | BICD2 | S582 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TDM6 | DLG5 | S1232 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8WWM7 | ATXN2L | S339 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WZ42 | TTN | S4099 | psp | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. {ECO:0000269|PubMed:11846417, ECO:0000269|PubMed:9804419}. |
| Q92616 | GCN1 | S1412 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q92797 | SYMPK | S547 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92934 | BAD | S74 | ochoa|psp | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q93074 | MED12 | S559 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96C24 | SYTL4 | S74 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96PC5 | MIA2 | S1243 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96PK6 | RBM14 | S582 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96RY5 | CRAMP1 | S533 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99958 | FOXC2 | S367 | psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BSA4 | TTYH2 | S504 | ochoa | Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2) | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q3TH73, ECO:0000269|PubMed:15010458}. |
| Q9BUH8 | BEGAIN | S440 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BUH8 | BEGAIN | S465 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9GZY8 | MFF | S229 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H1A4 | ANAPC1 | S688 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H7Z7 | PTGES2 | S46 | ochoa | Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:17585783, PubMed:18198127). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:17585783, PubMed:18198127). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity) (PubMed:17585783). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}. |
| Q9NP31 | SH2D2A | S296 | ochoa | SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Q9NPF5 | DMAP1 | S418 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
| Q9NRA8 | EIF4ENIF1 | S78 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRF2 | SH2B1 | S88 | ochoa | SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity). {ECO:0000250|UniProtKB:Q91ZM2, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}. |
| Q9NSD4 | ZNF275 | S91 | ochoa | Zinc finger protein 275 | May be involved in transcriptional regulation. |
| Q9NUJ3 | TCP11L1 | S300 | ochoa | T-complex protein 11-like protein 1 | None |
| Q9NY65 | TUBA8 | S379 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NYF8 | BCLAF1 | S320 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P227 | ARHGAP23 | S1230 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UBU7 | DBF4 | S103 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UKM9 | RALY | S135 | ochoa|psp | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9UPS6 | SETD1B | S1298 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9Y3P8 | SIT1 | S102 | ochoa | Signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein) (Suppression-inducing transmembrane adapter 1) (gp30/40) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269|PubMed:10209036}. |
| Q9Y4Z2 | NEUROG3 | S183 | psp | Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5) | Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}. |
| R4GMW8 | BIVM-ERCC5 | S838 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q13155 | AIMP2 | S51 | Sugiyama | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) | Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}. |
| Q8NFA2 | NOXO1 | S159 | SIGNOR | NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5) | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}. |
| P14543 | NID1 | S333 | SIGNOR | Nidogen-1 (NID-1) (Entactin) | Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. |
| P35916 | FLT4 | S936 | Sugiyama | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| P51659 | HSD17B4 | S185 | Sugiyama | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| Q9NRA0 | SPHK2 | S377 | Sugiyama | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.302133e-08 | 7.885 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.690684e-08 | 7.772 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.757328e-08 | 7.560 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 8.006835e-08 | 7.097 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.350073e-07 | 6.870 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.659273e-07 | 6.780 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.710126e-07 | 6.567 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.338967e-07 | 6.476 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.675566e-07 | 6.435 |
| R-HSA-190861 | Gap junction assembly | 4.906794e-07 | 6.309 |
| R-HSA-9646399 | Aggrephagy | 1.076862e-06 | 5.968 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.367446e-06 | 5.864 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.487500e-06 | 5.828 |
| R-HSA-190828 | Gap junction trafficking | 1.920862e-06 | 5.717 |
| R-HSA-437239 | Recycling pathway of L1 | 2.644820e-06 | 5.578 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.240654e-06 | 5.489 |
| R-HSA-983189 | Kinesins | 8.787159e-06 | 5.056 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.062402e-05 | 4.974 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.034073e-05 | 4.985 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.638147e-05 | 4.786 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.102893e-05 | 4.677 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.335124e-05 | 4.632 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.818084e-05 | 4.550 |
| R-HSA-373760 | L1CAM interactions | 3.647825e-05 | 4.438 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.693204e-05 | 4.433 |
| R-HSA-9833482 | PKR-mediated signaling | 3.693204e-05 | 4.433 |
| R-HSA-5620924 | Intraflagellar transport | 4.799164e-05 | 4.319 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.401786e-05 | 4.267 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.301328e-05 | 4.201 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.954428e-05 | 4.225 |
| R-HSA-9663891 | Selective autophagy | 6.301328e-05 | 4.201 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.954428e-05 | 4.225 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.172346e-05 | 4.088 |
| R-HSA-391251 | Protein folding | 8.286108e-05 | 4.082 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.074001e-04 | 3.969 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.441194e-04 | 3.841 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.586491e-04 | 3.800 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.078297e-04 | 3.682 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.871950e-04 | 3.542 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.709623e-04 | 3.431 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.007228e-04 | 3.397 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.198461e-04 | 3.377 |
| R-HSA-913531 | Interferon Signaling | 5.081615e-04 | 3.294 |
| R-HSA-69275 | G2/M Transition | 5.807741e-04 | 3.236 |
| R-HSA-5617833 | Cilium Assembly | 6.501778e-04 | 3.187 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.146973e-04 | 3.211 |
| R-HSA-9609690 | HCMV Early Events | 7.664761e-04 | 3.116 |
| R-HSA-1632852 | Macroautophagy | 8.395469e-04 | 3.076 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.527507e-04 | 3.069 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.030547e-03 | 2.987 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.089049e-03 | 2.963 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 1.234193e-03 | 2.909 |
| R-HSA-68882 | Mitotic Anaphase | 1.308673e-03 | 2.883 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.340477e-03 | 2.873 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.482995e-03 | 2.829 |
| R-HSA-109582 | Hemostasis | 1.318855e-03 | 2.880 |
| R-HSA-9612973 | Autophagy | 1.371030e-03 | 2.863 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.831302e-03 | 2.737 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.544533e-03 | 2.594 |
| R-HSA-9609646 | HCMV Infection | 2.777148e-03 | 2.556 |
| R-HSA-392518 | Signal amplification | 2.982575e-03 | 2.525 |
| R-HSA-68877 | Mitotic Prometaphase | 3.638424e-03 | 2.439 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.559516e-03 | 2.341 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.599445e-03 | 2.252 |
| R-HSA-199991 | Membrane Trafficking | 6.617908e-03 | 2.179 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 6.869635e-03 | 2.163 |
| R-HSA-68886 | M Phase | 6.959018e-03 | 2.157 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.525896e-03 | 2.123 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 7.804183e-03 | 2.108 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 8.608757e-03 | 2.065 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 9.448879e-03 | 2.025 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 1.123370e-02 | 1.949 |
| R-HSA-186712 | Regulation of beta-cell development | 1.144407e-02 | 1.941 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.185922e-02 | 1.926 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.416479e-02 | 1.849 |
| R-HSA-114608 | Platelet degranulation | 1.719321e-02 | 1.765 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.738862e-02 | 1.760 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.858786e-02 | 1.731 |
| R-HSA-9909396 | Circadian clock | 1.966918e-02 | 1.706 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.010213e-02 | 1.697 |
| R-HSA-5619101 | Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG... | 2.046891e-02 | 1.689 |
| R-HSA-5660686 | Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG... | 2.046891e-02 | 1.689 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 2.719918e-02 | 1.565 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.818565e-02 | 1.550 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.868865e-02 | 1.542 |
| R-HSA-1640170 | Cell Cycle | 2.940495e-02 | 1.532 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.193440e-02 | 1.496 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 4.052254e-02 | 1.392 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 4.052254e-02 | 1.392 |
| R-HSA-422475 | Axon guidance | 4.244903e-02 | 1.372 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.050899e-02 | 1.297 |
| R-HSA-112316 | Neuronal System | 5.295148e-02 | 1.276 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 5.366505e-02 | 1.270 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 5.366505e-02 | 1.270 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 5.366505e-02 | 1.270 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 5.366505e-02 | 1.270 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 5.366505e-02 | 1.270 |
| R-HSA-75153 | Apoptotic execution phase | 5.399341e-02 | 1.268 |
| R-HSA-9675108 | Nervous system development | 5.740443e-02 | 1.241 |
| R-HSA-210746 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | 6.016925e-02 | 1.221 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 6.016925e-02 | 1.221 |
| R-HSA-446107 | Type I hemidesmosome assembly | 7.304503e-02 | 1.136 |
| R-HSA-4839744 | Signaling by APC mutants | 9.203163e-02 | 1.036 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 9.203163e-02 | 1.036 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 9.203163e-02 | 1.036 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 9.203163e-02 | 1.036 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 9.827445e-02 | 1.008 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 9.827445e-02 | 1.008 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.044747e-01 | 0.981 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.044747e-01 | 0.981 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.044747e-01 | 0.981 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.044747e-01 | 0.981 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.044747e-01 | 0.981 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.044747e-01 | 0.981 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.228232e-01 | 0.911 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.228232e-01 | 0.911 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.288562e-01 | 0.890 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.288562e-01 | 0.890 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 8.667045e-02 | 1.062 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 8.667045e-02 | 1.062 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 9.293267e-02 | 1.032 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.080268e-01 | 0.966 |
| R-HSA-380287 | Centrosome maturation | 1.124534e-01 | 0.949 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 9.203163e-02 | 1.036 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.164647e-01 | 0.934 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 6.662914e-02 | 1.176 |
| R-HSA-4839735 | Signaling by AXIN mutants | 9.827445e-02 | 1.008 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 9.827445e-02 | 1.008 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 7.304503e-02 | 1.136 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 8.574598e-02 | 1.067 |
| R-HSA-1483226 | Synthesis of PI | 9.203163e-02 | 1.036 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 9.827445e-02 | 1.008 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.044747e-01 | 0.981 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 7.941721e-02 | 1.100 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 9.827445e-02 | 1.008 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.288562e-01 | 0.890 |
| R-HSA-9664420 | Killing mechanisms | 1.288562e-01 | 0.890 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.044747e-01 | 0.981 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.044747e-01 | 0.981 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.044747e-01 | 0.981 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 8.257038e-02 | 1.083 |
| R-HSA-2586552 | Signaling by Leptin | 8.574598e-02 | 1.067 |
| R-HSA-194138 | Signaling by VEGF | 7.317977e-02 | 1.136 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.167488e-01 | 0.933 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 7.941721e-02 | 1.100 |
| R-HSA-391908 | Prostanoid ligand receptors | 9.203163e-02 | 1.036 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.044747e-01 | 0.981 |
| R-HSA-9020558 | Interleukin-2 signaling | 9.203163e-02 | 1.036 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 7.941721e-02 | 1.100 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.102342e-01 | 0.958 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.939292e-02 | 1.003 |
| R-HSA-4839726 | Chromatin organization | 1.159652e-01 | 0.936 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.489212e-02 | 1.188 |
| R-HSA-8983711 | OAS antiviral response | 1.044747e-01 | 0.981 |
| R-HSA-109581 | Apoptosis | 1.285149e-01 | 0.891 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.036491e-01 | 0.984 |
| R-HSA-1266738 | Developmental Biology | 1.287060e-01 | 0.890 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.824375e-02 | 1.107 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.348480e-01 | 0.870 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.525796e-01 | 0.817 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.642001e-01 | 0.785 |
| R-HSA-390522 | Striated Muscle Contraction | 2.412387e-01 | 0.618 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.464640e-01 | 0.608 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.493776e-01 | 0.826 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.513232e-01 | 0.600 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.513232e-01 | 0.600 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 1.699510e-01 | 0.770 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.513232e-01 | 0.600 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.467095e-01 | 0.834 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.686513e-01 | 0.773 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.407990e-01 | 0.851 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.199758e-01 | 0.658 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.981225e-01 | 0.703 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.306800e-01 | 0.637 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.699510e-01 | 0.770 |
| R-HSA-2424491 | DAP12 signaling | 2.199758e-01 | 0.658 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.145684e-01 | 0.668 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.348480e-01 | 0.870 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.756627e-01 | 0.755 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.869695e-01 | 0.728 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.036421e-01 | 0.691 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.199758e-01 | 0.658 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.525796e-01 | 0.817 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.584098e-01 | 0.800 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.568080e-01 | 0.590 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.348480e-01 | 0.870 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.199758e-01 | 0.658 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.329210e-01 | 0.876 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.036421e-01 | 0.691 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.199758e-01 | 0.658 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 2.145684e-01 | 0.668 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.253462e-01 | 0.647 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.883206e-01 | 0.725 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.359774e-01 | 0.627 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.032736e-01 | 0.692 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.568080e-01 | 0.590 |
| R-HSA-3000157 | Laminin interactions | 1.925651e-01 | 0.715 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.306800e-01 | 0.637 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 1.925651e-01 | 0.715 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.348480e-01 | 0.870 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 2.619271e-01 | 0.582 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.234077e-01 | 0.651 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.619271e-01 | 0.582 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 1.813354e-01 | 0.742 |
| R-HSA-69481 | G2/M Checkpoints | 2.564144e-01 | 0.591 |
| R-HSA-3214842 | HDMs demethylate histones | 1.925651e-01 | 0.715 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.306800e-01 | 0.637 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.516537e-01 | 0.599 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.310010e-01 | 0.636 |
| R-HSA-180292 | GAB1 signalosome | 1.467095e-01 | 0.834 |
| R-HSA-354192 | Integrin signaling | 2.359774e-01 | 0.627 |
| R-HSA-5673000 | RAF activation | 2.464640e-01 | 0.608 |
| R-HSA-373753 | Nephrin family interactions | 1.584098e-01 | 0.800 |
| R-HSA-9830674 | Formation of the ureteric bud | 1.813354e-01 | 0.742 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.359774e-01 | 0.627 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.619271e-01 | 0.582 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.467095e-01 | 0.834 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 1.584098e-01 | 0.800 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.359774e-01 | 0.627 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.659709e-01 | 0.780 |
| R-HSA-1500931 | Cell-Cell communication | 2.024423e-01 | 0.694 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.375792e-01 | 0.861 |
| R-HSA-5357801 | Programmed Cell Death | 2.032340e-01 | 0.692 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.803118e-01 | 0.744 |
| R-HSA-2262752 | Cellular responses to stress | 1.796899e-01 | 0.745 |
| R-HSA-162582 | Signal Transduction | 1.972941e-01 | 0.705 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.813354e-01 | 0.742 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.568080e-01 | 0.590 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.284678e-01 | 0.641 |
| R-HSA-157118 | Signaling by NOTCH | 2.668336e-01 | 0.574 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 2.670112e-01 | 0.573 |
| R-HSA-9824446 | Viral Infection Pathways | 2.676034e-01 | 0.573 |
| R-HSA-9843745 | Adipogenesis | 2.691498e-01 | 0.570 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.720606e-01 | 0.565 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.720606e-01 | 0.565 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.770756e-01 | 0.557 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.770756e-01 | 0.557 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.770756e-01 | 0.557 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.770756e-01 | 0.557 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.820563e-01 | 0.550 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.820563e-01 | 0.550 |
| R-HSA-9607240 | FLT3 Signaling | 2.820563e-01 | 0.550 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.870030e-01 | 0.542 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.870030e-01 | 0.542 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 2.870030e-01 | 0.542 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.919159e-01 | 0.535 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.919159e-01 | 0.535 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.004740e-01 | 0.522 |
| R-HSA-2172127 | DAP12 interactions | 3.016414e-01 | 0.521 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.064543e-01 | 0.514 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.112344e-01 | 0.507 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.112344e-01 | 0.507 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.112344e-01 | 0.507 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.112344e-01 | 0.507 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.112344e-01 | 0.507 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.159819e-01 | 0.500 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 3.159819e-01 | 0.500 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.224582e-01 | 0.492 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.253796e-01 | 0.488 |
| R-HSA-69306 | DNA Replication | 3.300137e-01 | 0.481 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 3.300305e-01 | 0.481 |
| R-HSA-1989781 | PPARA activates gene expression | 3.350384e-01 | 0.475 |
| R-HSA-446728 | Cell junction organization | 3.381070e-01 | 0.471 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.392369e-01 | 0.469 |
| R-HSA-72187 | mRNA 3'-end processing | 3.392369e-01 | 0.469 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.392369e-01 | 0.469 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.400524e-01 | 0.468 |
| R-HSA-9711097 | Cellular response to starvation | 3.425552e-01 | 0.465 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.437931e-01 | 0.464 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.437931e-01 | 0.464 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.437931e-01 | 0.464 |
| R-HSA-877300 | Interferon gamma signaling | 3.450552e-01 | 0.462 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.483180e-01 | 0.458 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.528121e-01 | 0.452 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.528121e-01 | 0.452 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.572755e-01 | 0.447 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.572755e-01 | 0.447 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.572755e-01 | 0.447 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.572755e-01 | 0.447 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.572755e-01 | 0.447 |
| R-HSA-177929 | Signaling by EGFR | 3.572755e-01 | 0.447 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.575084e-01 | 0.447 |
| R-HSA-5621480 | Dectin-2 family | 3.617083e-01 | 0.442 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.661108e-01 | 0.436 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 3.661108e-01 | 0.436 |
| R-HSA-9033241 | Peroxisomal protein import | 3.704833e-01 | 0.431 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.704833e-01 | 0.431 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 3.704833e-01 | 0.431 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.704833e-01 | 0.431 |
| R-HSA-379724 | tRNA Aminoacylation | 3.748258e-01 | 0.426 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 3.748258e-01 | 0.426 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.748258e-01 | 0.426 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.748258e-01 | 0.426 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.748258e-01 | 0.426 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.748258e-01 | 0.426 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.748258e-01 | 0.426 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.791387e-01 | 0.421 |
| R-HSA-9707616 | Heme signaling | 3.834221e-01 | 0.416 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.834221e-01 | 0.416 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.834221e-01 | 0.416 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.876762e-01 | 0.412 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.876762e-01 | 0.412 |
| R-HSA-8848021 | Signaling by PTK6 | 3.876762e-01 | 0.412 |
| R-HSA-212436 | Generic Transcription Pathway | 4.008897e-01 | 0.397 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.023510e-01 | 0.395 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 4.044036e-01 | 0.393 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.044036e-01 | 0.393 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.044036e-01 | 0.393 |
| R-HSA-9830369 | Kidney development | 4.044036e-01 | 0.393 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.085143e-01 | 0.389 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.085143e-01 | 0.389 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.166513e-01 | 0.380 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.183550e-01 | 0.378 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.206781e-01 | 0.376 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.206781e-01 | 0.376 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.219750e-01 | 0.375 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.278323e-01 | 0.369 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.286493e-01 | 0.368 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.286493e-01 | 0.368 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.325941e-01 | 0.364 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.365118e-01 | 0.360 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.365118e-01 | 0.360 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.404028e-01 | 0.356 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.442671e-01 | 0.352 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.481050e-01 | 0.349 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.481050e-01 | 0.349 |
| R-HSA-9659379 | Sensory processing of sound | 4.519166e-01 | 0.345 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.557021e-01 | 0.341 |
| R-HSA-1280218 | Adaptive Immune System | 4.557950e-01 | 0.341 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.594617e-01 | 0.338 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.631956e-01 | 0.334 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.631956e-01 | 0.334 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.653576e-01 | 0.332 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.669039e-01 | 0.331 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.705868e-01 | 0.327 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 4.705868e-01 | 0.327 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.742445e-01 | 0.324 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.742445e-01 | 0.324 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.742445e-01 | 0.324 |
| R-HSA-397014 | Muscle contraction | 4.762169e-01 | 0.322 |
| R-HSA-156902 | Peptide chain elongation | 4.886265e-01 | 0.311 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.991566e-01 | 0.302 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.991566e-01 | 0.302 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.026186e-01 | 0.299 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.060569e-01 | 0.296 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.094717e-01 | 0.293 |
| R-HSA-2029481 | FCGR activation | 5.094717e-01 | 0.293 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.094717e-01 | 0.293 |
| R-HSA-1474290 | Collagen formation | 5.128631e-01 | 0.290 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.162312e-01 | 0.287 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.195763e-01 | 0.284 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.195763e-01 | 0.284 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.195763e-01 | 0.284 |
| R-HSA-72312 | rRNA processing | 5.199557e-01 | 0.284 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.228984e-01 | 0.282 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.228984e-01 | 0.282 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.261978e-01 | 0.279 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.327288e-01 | 0.273 |
| R-HSA-3214847 | HATs acetylate histones | 5.327288e-01 | 0.273 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.327288e-01 | 0.273 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.327288e-01 | 0.273 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.359608e-01 | 0.271 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.391706e-01 | 0.268 |
| R-HSA-192823 | Viral mRNA Translation | 5.455244e-01 | 0.263 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.486687e-01 | 0.261 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.517914e-01 | 0.258 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.517914e-01 | 0.258 |
| R-HSA-9833110 | RSV-host interactions | 5.517914e-01 | 0.258 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.548927e-01 | 0.256 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.610316e-01 | 0.251 |
| R-HSA-69239 | Synthesis of DNA | 5.610316e-01 | 0.251 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.640695e-01 | 0.249 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.640695e-01 | 0.249 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.640695e-01 | 0.249 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 5.700830e-01 | 0.244 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.760143e-01 | 0.240 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.760143e-01 | 0.240 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.760143e-01 | 0.240 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.760143e-01 | 0.240 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.818645e-01 | 0.235 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 5.904900e-01 | 0.229 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 5.904900e-01 | 0.229 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.933259e-01 | 0.227 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.933259e-01 | 0.227 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.961422e-01 | 0.225 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.128740e-01 | 0.213 |
| R-HSA-9658195 | Leishmania infection | 6.165117e-01 | 0.210 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.165117e-01 | 0.210 |
| R-HSA-69206 | G1/S Transition | 6.206352e-01 | 0.207 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.232641e-01 | 0.205 |
| R-HSA-74160 | Gene expression (Transcription) | 6.249098e-01 | 0.204 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.308034e-01 | 0.200 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.401892e-01 | 0.194 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.411675e-01 | 0.193 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.412510e-01 | 0.193 |
| R-HSA-5663205 | Infectious disease | 6.426375e-01 | 0.192 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.429698e-01 | 0.192 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.558404e-01 | 0.183 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.582274e-01 | 0.182 |
| R-HSA-9664407 | Parasite infection | 6.629523e-01 | 0.179 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.629523e-01 | 0.179 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.629523e-01 | 0.179 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.652905e-01 | 0.177 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.789854e-01 | 0.168 |
| R-HSA-69242 | S Phase | 6.834258e-01 | 0.165 |
| R-HSA-9758941 | Gastrulation | 6.856231e-01 | 0.164 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.878053e-01 | 0.163 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.921248e-01 | 0.160 |
| R-HSA-2142753 | Arachidonate metabolism | 6.921248e-01 | 0.160 |
| R-HSA-9609507 | Protein localization | 6.942623e-01 | 0.158 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.942623e-01 | 0.158 |
| R-HSA-73887 | Death Receptor Signaling | 6.963850e-01 | 0.157 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.984932e-01 | 0.156 |
| R-HSA-1643685 | Disease | 6.986584e-01 | 0.156 |
| R-HSA-1474244 | Extracellular matrix organization | 6.991404e-01 | 0.155 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.047311e-01 | 0.152 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.088184e-01 | 0.149 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.152318e-01 | 0.146 |
| R-HSA-5619102 | SLC transporter disorders | 7.226874e-01 | 0.141 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.303166e-01 | 0.136 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.321911e-01 | 0.135 |
| R-HSA-597592 | Post-translational protein modification | 7.328045e-01 | 0.135 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.359016e-01 | 0.133 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.359016e-01 | 0.133 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.377377e-01 | 0.132 |
| R-HSA-73894 | DNA Repair | 7.400184e-01 | 0.131 |
| R-HSA-168255 | Influenza Infection | 7.467300e-01 | 0.127 |
| R-HSA-2559583 | Cellular Senescence | 7.484915e-01 | 0.126 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.537033e-01 | 0.123 |
| R-HSA-983712 | Ion channel transport | 7.638081e-01 | 0.117 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.719140e-01 | 0.112 |
| R-HSA-428157 | Sphingolipid metabolism | 7.828012e-01 | 0.106 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.858161e-01 | 0.105 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.858161e-01 | 0.105 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.858161e-01 | 0.105 |
| R-HSA-72172 | mRNA Splicing | 7.887895e-01 | 0.103 |
| R-HSA-8978868 | Fatty acid metabolism | 7.973360e-01 | 0.098 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.189161e-01 | 0.087 |
| R-HSA-72766 | Translation | 8.196965e-01 | 0.086 |
| R-HSA-168256 | Immune System | 8.259259e-01 | 0.083 |
| R-HSA-449147 | Signaling by Interleukins | 8.268190e-01 | 0.083 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.436868e-01 | 0.074 |
| R-HSA-8953854 | Metabolism of RNA | 8.470489e-01 | 0.072 |
| R-HSA-5688426 | Deubiquitination | 8.522129e-01 | 0.069 |
| R-HSA-416476 | G alpha (q) signalling events | 8.612548e-01 | 0.065 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.650954e-01 | 0.063 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.777261e-01 | 0.057 |
| R-HSA-1483257 | Phospholipid metabolism | 8.884021e-01 | 0.051 |
| R-HSA-195721 | Signaling by WNT | 8.907315e-01 | 0.050 |
| R-HSA-8957322 | Metabolism of steroids | 9.090031e-01 | 0.041 |
| R-HSA-392499 | Metabolism of proteins | 9.233915e-01 | 0.035 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.308841e-01 | 0.031 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.375939e-01 | 0.028 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.404150e-01 | 0.027 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.448751e-01 | 0.025 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.460330e-01 | 0.024 |
| R-HSA-418594 | G alpha (i) signalling events | 9.497213e-01 | 0.022 |
| R-HSA-556833 | Metabolism of lipids | 9.544497e-01 | 0.020 |
| R-HSA-6798695 | Neutrophil degranulation | 9.647330e-01 | 0.016 |
| R-HSA-388396 | GPCR downstream signalling | 9.754790e-01 | 0.011 |
| R-HSA-9679506 | SARS-CoV Infections | 9.824586e-01 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 9.853274e-01 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 9.862473e-01 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 9.933095e-01 | 0.003 |
| R-HSA-168249 | Innate Immune System | 9.993292e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998801e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999936e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
DYRK2 |
0.758 | 0.502 | 1 | 0.854 |
KIS |
0.758 | 0.418 | 1 | 0.880 |
HIPK2 |
0.757 | 0.475 | 1 | 0.879 |
DYRK4 |
0.755 | 0.490 | 1 | 0.889 |
CDK18 |
0.754 | 0.493 | 1 | 0.887 |
DYRK3 |
0.752 | 0.499 | 1 | 0.818 |
P38D |
0.750 | 0.494 | 1 | 0.894 |
CDK19 |
0.746 | 0.440 | 1 | 0.885 |
CDK12 |
0.746 | 0.510 | 1 | 0.896 |
PRP4 |
0.746 | 0.650 | -3 | 0.826 |
CDK7 |
0.746 | 0.468 | 1 | 0.891 |
CDK8 |
0.746 | 0.442 | 1 | 0.881 |
P38G |
0.745 | 0.493 | 1 | 0.883 |
CDK13 |
0.745 | 0.486 | 1 | 0.894 |
CDK17 |
0.745 | 0.475 | 1 | 0.883 |
P38B |
0.745 | 0.480 | 1 | 0.881 |
CLK3 |
0.744 | 0.340 | 1 | 0.719 |
HIPK4 |
0.742 | 0.317 | 1 | 0.749 |
DYRK1B |
0.741 | 0.469 | 1 | 0.861 |
CDK14 |
0.741 | 0.497 | 1 | 0.879 |
HIPK1 |
0.741 | 0.450 | 1 | 0.846 |
ERK1 |
0.740 | 0.456 | 1 | 0.892 |
JNK2 |
0.740 | 0.482 | 1 | 0.898 |
CLK4 |
0.740 | 0.391 | -3 | 0.428 |
NLK |
0.739 | 0.501 | 1 | 0.756 |
P38A |
0.738 | 0.473 | 1 | 0.864 |
CLK2 |
0.738 | 0.348 | -3 | 0.427 |
AURC |
0.737 | 0.357 | -2 | 0.860 |
CDK1 |
0.736 | 0.427 | 1 | 0.880 |
DYRK1A |
0.736 | 0.387 | 1 | 0.846 |
CDK16 |
0.734 | 0.454 | 1 | 0.888 |
HIPK3 |
0.734 | 0.448 | 1 | 0.831 |
CLK1 |
0.734 | 0.341 | -3 | 0.415 |
JNK3 |
0.734 | 0.464 | 1 | 0.895 |
CDK3 |
0.733 | 0.406 | 1 | 0.888 |
CDK9 |
0.733 | 0.468 | 1 | 0.887 |
CDK10 |
0.732 | 0.449 | 1 | 0.885 |
CDK5 |
0.732 | 0.427 | 1 | 0.878 |
AURA |
0.730 | 0.379 | -2 | 0.886 |
SRPK1 |
0.729 | 0.195 | -3 | 0.412 |
ERK5 |
0.728 | 0.257 | 1 | 0.682 |
ERK2 |
0.726 | 0.443 | 1 | 0.866 |
AURB |
0.724 | 0.353 | -2 | 0.861 |
MAK |
0.722 | 0.309 | -2 | 0.675 |
PAK6 |
0.721 | 0.294 | -2 | 0.841 |
CDK4 |
0.721 | 0.463 | 1 | 0.898 |
ICK |
0.719 | 0.242 | -3 | 0.461 |
PKACB |
0.719 | 0.263 | -2 | 0.825 |
SRPK2 |
0.719 | 0.139 | -3 | 0.355 |
JNK1 |
0.717 | 0.412 | 1 | 0.889 |
CDK6 |
0.717 | 0.433 | 1 | 0.885 |
SKMLCK |
0.717 | 0.251 | -2 | 0.764 |
PRKD2 |
0.715 | 0.090 | -3 | 0.452 |
PKG2 |
0.715 | 0.273 | -2 | 0.789 |
MTOR |
0.715 | 0.095 | 1 | 0.581 |
CDK2 |
0.714 | 0.326 | 1 | 0.824 |
CDKL5 |
0.714 | 0.089 | -3 | 0.427 |
PRKD1 |
0.713 | 0.068 | -3 | 0.483 |
MNK2 |
0.713 | 0.261 | -2 | 0.794 |
PAK1 |
0.713 | 0.261 | -2 | 0.834 |
PKACG |
0.713 | 0.202 | -2 | 0.761 |
PRKX |
0.713 | 0.204 | -3 | 0.409 |
CAMLCK |
0.712 | 0.286 | -2 | 0.774 |
PKACA |
0.710 | 0.250 | -2 | 0.813 |
PAK3 |
0.710 | 0.257 | -2 | 0.809 |
CDKL1 |
0.710 | 0.064 | -3 | 0.425 |
RSK2 |
0.710 | 0.104 | -3 | 0.431 |
COT |
0.709 | -0.056 | 2 | 0.833 |
RSK3 |
0.709 | 0.107 | -3 | 0.424 |
SRPK3 |
0.708 | 0.117 | -3 | 0.370 |
PAK5 |
0.708 | 0.299 | -2 | 0.832 |
MOS |
0.707 | 0.019 | 1 | 0.506 |
PAK4 |
0.707 | 0.302 | -2 | 0.865 |
MYLK4 |
0.707 | 0.243 | -2 | 0.824 |
MSK1 |
0.707 | 0.206 | -3 | 0.394 |
CAMK1B |
0.706 | 0.079 | -3 | 0.465 |
PIM3 |
0.704 | 0.014 | -3 | 0.477 |
RIPK3 |
0.704 | 0.089 | 3 | 0.694 |
DAPK2 |
0.704 | 0.213 | -3 | 0.480 |
CDC7 |
0.704 | -0.043 | 1 | 0.441 |
P90RSK |
0.704 | 0.067 | -3 | 0.444 |
PAK2 |
0.704 | 0.269 | -2 | 0.828 |
ATR |
0.704 | 0.026 | 1 | 0.491 |
AKT2 |
0.704 | 0.146 | -3 | 0.373 |
IKKB |
0.704 | -0.090 | -2 | 0.488 |
RAF1 |
0.703 | -0.051 | 1 | 0.465 |
TBK1 |
0.703 | -0.051 | 1 | 0.420 |
IKKE |
0.702 | -0.052 | 1 | 0.414 |
MSK2 |
0.702 | 0.137 | -3 | 0.391 |
PRPK |
0.701 | -0.081 | -1 | 0.682 |
WNK1 |
0.701 | 0.036 | -2 | 0.669 |
NDR2 |
0.701 | -0.008 | -3 | 0.490 |
PDHK4 |
0.700 | -0.089 | 1 | 0.517 |
PKN3 |
0.700 | 0.024 | -3 | 0.479 |
MOK |
0.700 | 0.268 | 1 | 0.767 |
AKT1 |
0.700 | 0.191 | -3 | 0.396 |
MNK1 |
0.699 | 0.194 | -2 | 0.772 |
PKN2 |
0.699 | 0.053 | -3 | 0.471 |
MST4 |
0.699 | 0.034 | 2 | 0.808 |
P70S6KB |
0.699 | 0.088 | -3 | 0.432 |
NDR1 |
0.699 | 0.040 | -3 | 0.479 |
ERK7 |
0.697 | 0.188 | 2 | 0.554 |
PIM1 |
0.697 | 0.032 | -3 | 0.434 |
SMG1 |
0.697 | 0.083 | 1 | 0.460 |
PRKD3 |
0.696 | 0.046 | -3 | 0.399 |
BMPR2 |
0.696 | -0.086 | -2 | 0.574 |
NUAK2 |
0.696 | -0.015 | -3 | 0.475 |
RSK4 |
0.696 | 0.102 | -3 | 0.427 |
SGK3 |
0.695 | 0.136 | -3 | 0.435 |
GCN2 |
0.695 | -0.141 | 2 | 0.759 |
NIK |
0.695 | 0.046 | -3 | 0.492 |
CHAK2 |
0.694 | -0.034 | -1 | 0.662 |
PKCD |
0.694 | 0.077 | 2 | 0.748 |
MAPKAPK3 |
0.694 | -0.010 | -3 | 0.433 |
CAMK4 |
0.693 | 0.075 | -3 | 0.456 |
PDHK1 |
0.693 | -0.115 | 1 | 0.502 |
DSTYK |
0.693 | -0.140 | 2 | 0.835 |
NEK6 |
0.692 | -0.075 | -2 | 0.541 |
CAMK2G |
0.692 | -0.083 | 2 | 0.782 |
GSK3A |
0.691 | 0.154 | 4 | 0.391 |
ULK2 |
0.691 | -0.125 | 2 | 0.744 |
MAPKAPK2 |
0.691 | -0.030 | -3 | 0.407 |
PINK1 |
0.690 | 0.104 | 1 | 0.655 |
TGFBR2 |
0.690 | -0.057 | -2 | 0.517 |
WNK3 |
0.690 | -0.060 | 1 | 0.460 |
ATM |
0.689 | -0.033 | 1 | 0.439 |
IKKA |
0.689 | -0.087 | -2 | 0.452 |
GRK1 |
0.689 | -0.056 | -2 | 0.533 |
MLK1 |
0.689 | -0.083 | 2 | 0.768 |
GRK5 |
0.688 | -0.114 | -3 | 0.456 |
AKT3 |
0.688 | 0.151 | -3 | 0.346 |
NEK7 |
0.688 | -0.148 | -3 | 0.448 |
IRE1 |
0.687 | -0.012 | 1 | 0.443 |
PIM2 |
0.686 | 0.061 | -3 | 0.403 |
PKCA |
0.686 | 0.082 | 2 | 0.693 |
CAMK2D |
0.686 | -0.067 | -3 | 0.470 |
AMPKA1 |
0.686 | -0.024 | -3 | 0.492 |
RIPK1 |
0.686 | -0.037 | 1 | 0.436 |
PKG1 |
0.685 | 0.224 | -2 | 0.771 |
MRCKB |
0.685 | 0.198 | -3 | 0.404 |
PKCZ |
0.685 | 0.071 | 2 | 0.738 |
TSSK2 |
0.685 | 0.010 | -5 | 0.788 |
PKCG |
0.684 | 0.046 | 2 | 0.712 |
NEK9 |
0.684 | -0.081 | 2 | 0.781 |
DNAPK |
0.684 | -0.009 | 1 | 0.440 |
GRK7 |
0.684 | -0.024 | 1 | 0.446 |
PHKG1 |
0.684 | -0.018 | -3 | 0.480 |
HUNK |
0.683 | -0.102 | 2 | 0.814 |
TSSK1 |
0.683 | -0.000 | -3 | 0.516 |
MLK2 |
0.683 | -0.053 | 2 | 0.761 |
SGK1 |
0.683 | 0.121 | -3 | 0.327 |
LATS2 |
0.683 | -0.059 | -5 | 0.666 |
SMMLCK |
0.683 | 0.178 | -3 | 0.439 |
BMPR1B |
0.683 | -0.037 | 1 | 0.391 |
MASTL |
0.682 | -0.127 | -2 | 0.540 |
AMPKA2 |
0.682 | -0.023 | -3 | 0.471 |
MARK4 |
0.682 | -0.068 | 4 | 0.719 |
BCKDK |
0.682 | -0.127 | -1 | 0.641 |
NEK2 |
0.681 | 0.010 | 2 | 0.766 |
MLK3 |
0.681 | -0.039 | 2 | 0.705 |
GRK6 |
0.681 | -0.104 | 1 | 0.443 |
DAPK3 |
0.681 | 0.201 | -3 | 0.451 |
ULK1 |
0.680 | -0.162 | -3 | 0.442 |
MRCKA |
0.680 | 0.178 | -3 | 0.417 |
GRK4 |
0.680 | -0.142 | -2 | 0.531 |
PKR |
0.680 | 0.011 | 1 | 0.477 |
VRK2 |
0.679 | 0.082 | 1 | 0.546 |
NIM1 |
0.679 | -0.056 | 3 | 0.665 |
TGFBR1 |
0.679 | -0.046 | -2 | 0.496 |
CAMK2A |
0.679 | -0.037 | 2 | 0.768 |
ALK4 |
0.679 | -0.044 | -2 | 0.524 |
MELK |
0.679 | -0.028 | -3 | 0.460 |
PKCB |
0.679 | 0.013 | 2 | 0.690 |
LATS1 |
0.679 | -0.006 | -3 | 0.496 |
PKCH |
0.679 | 0.043 | 2 | 0.681 |
ANKRD3 |
0.678 | -0.122 | 1 | 0.481 |
DAPK1 |
0.678 | 0.198 | -3 | 0.435 |
CAMK2B |
0.678 | -0.062 | 2 | 0.741 |
BUB1 |
0.678 | 0.127 | -5 | 0.736 |
PKCI |
0.677 | 0.107 | 2 | 0.714 |
IRE2 |
0.677 | -0.025 | 2 | 0.704 |
NUAK1 |
0.676 | -0.078 | -3 | 0.431 |
DLK |
0.676 | -0.179 | 1 | 0.455 |
MPSK1 |
0.676 | 0.021 | 1 | 0.534 |
FAM20C |
0.676 | -0.030 | 2 | 0.574 |
PHKG2 |
0.676 | 0.000 | -3 | 0.452 |
MAPKAPK5 |
0.676 | -0.061 | -3 | 0.368 |
TLK2 |
0.676 | -0.064 | 1 | 0.467 |
CAMK1G |
0.676 | -0.006 | -3 | 0.400 |
GSK3B |
0.675 | 0.047 | 4 | 0.382 |
PKCT |
0.675 | 0.082 | 2 | 0.682 |
QSK |
0.675 | -0.038 | 4 | 0.696 |
YSK4 |
0.675 | -0.091 | 1 | 0.422 |
PKCE |
0.674 | 0.105 | 2 | 0.698 |
TTBK2 |
0.674 | -0.137 | 2 | 0.692 |
SBK |
0.674 | 0.070 | -3 | 0.298 |
DCAMKL1 |
0.673 | -0.020 | -3 | 0.466 |
CK1E |
0.673 | -0.067 | -3 | 0.282 |
QIK |
0.673 | -0.074 | -3 | 0.459 |
ROCK2 |
0.673 | 0.175 | -3 | 0.459 |
ACVR2B |
0.673 | -0.076 | -2 | 0.480 |
ALK2 |
0.673 | -0.053 | -2 | 0.516 |
DRAK1 |
0.672 | -0.042 | 1 | 0.384 |
P70S6K |
0.672 | 0.025 | -3 | 0.361 |
CK1D |
0.672 | -0.045 | -3 | 0.249 |
MEK1 |
0.672 | -0.105 | 2 | 0.805 |
MST3 |
0.672 | 0.036 | 2 | 0.806 |
CHK1 |
0.672 | -0.058 | -3 | 0.468 |
PKN1 |
0.671 | 0.040 | -3 | 0.389 |
DMPK1 |
0.671 | 0.201 | -3 | 0.427 |
PLK1 |
0.671 | -0.109 | -2 | 0.504 |
SIK |
0.671 | -0.066 | -3 | 0.409 |
CK1A2 |
0.671 | -0.036 | -3 | 0.245 |
CHK2 |
0.671 | 0.024 | -3 | 0.348 |
SNRK |
0.670 | -0.052 | 2 | 0.657 |
ACVR2A |
0.670 | -0.088 | -2 | 0.477 |
WNK4 |
0.669 | -0.028 | -2 | 0.642 |
CHAK1 |
0.669 | -0.104 | 2 | 0.745 |
CAMK1D |
0.669 | 0.018 | -3 | 0.377 |
LKB1 |
0.669 | 0.095 | -3 | 0.545 |
ROCK1 |
0.668 | 0.186 | -3 | 0.427 |
MLK4 |
0.667 | -0.105 | 2 | 0.686 |
DCAMKL2 |
0.667 | -0.033 | -3 | 0.461 |
TAO3 |
0.667 | -0.010 | 1 | 0.462 |
GRK2 |
0.667 | -0.097 | -2 | 0.482 |
PLK4 |
0.666 | -0.084 | 2 | 0.632 |
IRAK4 |
0.665 | -0.036 | 1 | 0.425 |
HRI |
0.665 | -0.122 | -2 | 0.535 |
CK1G1 |
0.665 | -0.084 | -3 | 0.264 |
NEK5 |
0.665 | -0.036 | 1 | 0.461 |
MEK5 |
0.665 | -0.077 | 2 | 0.775 |
CAMK1A |
0.664 | 0.044 | -3 | 0.351 |
BRSK1 |
0.663 | -0.076 | -3 | 0.443 |
MEKK1 |
0.663 | -0.091 | 1 | 0.460 |
BRSK2 |
0.663 | -0.088 | -3 | 0.462 |
SSTK |
0.663 | -0.004 | 4 | 0.686 |
PLK3 |
0.662 | -0.123 | 2 | 0.757 |
BMPR1A |
0.662 | -0.066 | 1 | 0.371 |
MEKK3 |
0.662 | -0.123 | 1 | 0.440 |
MEKK2 |
0.662 | -0.061 | 2 | 0.743 |
MARK3 |
0.661 | -0.077 | 4 | 0.664 |
TAO2 |
0.661 | 0.008 | 2 | 0.801 |
MARK2 |
0.661 | -0.079 | 4 | 0.640 |
PERK |
0.660 | -0.140 | -2 | 0.517 |
HPK1 |
0.660 | 0.036 | 1 | 0.448 |
PASK |
0.660 | -0.054 | -3 | 0.482 |
BRAF |
0.659 | -0.137 | -4 | 0.739 |
TTBK1 |
0.659 | -0.093 | 2 | 0.631 |
GAK |
0.659 | -0.020 | 1 | 0.506 |
PDK1 |
0.658 | -0.013 | 1 | 0.487 |
ZAK |
0.658 | -0.132 | 1 | 0.422 |
LOK |
0.658 | 0.030 | -2 | 0.575 |
TLK1 |
0.658 | -0.153 | -2 | 0.509 |
CRIK |
0.658 | 0.082 | -3 | 0.389 |
GCK |
0.657 | -0.010 | 1 | 0.461 |
GRK3 |
0.657 | -0.095 | -2 | 0.457 |
CAMKK1 |
0.656 | -0.122 | -2 | 0.525 |
CAMKK2 |
0.656 | -0.077 | -2 | 0.543 |
HGK |
0.656 | -0.005 | 3 | 0.787 |
NEK8 |
0.656 | -0.068 | 2 | 0.776 |
TNIK |
0.655 | 0.014 | 3 | 0.780 |
IRAK1 |
0.655 | -0.128 | -1 | 0.634 |
TAK1 |
0.655 | -0.053 | 1 | 0.490 |
NEK11 |
0.654 | -0.109 | 1 | 0.466 |
NEK4 |
0.654 | -0.062 | 1 | 0.433 |
KHS2 |
0.654 | 0.047 | 1 | 0.463 |
MARK1 |
0.653 | -0.109 | 4 | 0.676 |
CK2A2 |
0.653 | -0.054 | 1 | 0.343 |
SLK |
0.653 | -0.040 | -2 | 0.500 |
NEK1 |
0.652 | 0.004 | 1 | 0.431 |
LRRK2 |
0.652 | -0.025 | 2 | 0.810 |
RIPK2 |
0.651 | -0.077 | 1 | 0.404 |
KHS1 |
0.651 | 0.022 | 1 | 0.450 |
MINK |
0.651 | -0.049 | 1 | 0.440 |
PBK |
0.650 | -0.005 | 1 | 0.464 |
MEKK6 |
0.650 | -0.043 | 1 | 0.444 |
MST2 |
0.649 | -0.101 | 1 | 0.445 |
VRK1 |
0.648 | -0.025 | 2 | 0.810 |
CK2A1 |
0.647 | -0.048 | 1 | 0.320 |
MAP3K15 |
0.646 | -0.099 | 1 | 0.431 |
EEF2K |
0.644 | -0.064 | 3 | 0.725 |
YSK1 |
0.643 | -0.024 | 2 | 0.752 |
MYO3B |
0.643 | 0.074 | 2 | 0.773 |
STK33 |
0.643 | -0.080 | 2 | 0.635 |
PLK2 |
0.643 | -0.100 | -3 | 0.406 |
NEK3 |
0.641 | -0.039 | 1 | 0.431 |
HASPIN |
0.641 | -0.007 | -1 | 0.515 |
PDHK3_TYR |
0.640 | 0.138 | 4 | 0.753 |
MEK2 |
0.639 | -0.110 | 2 | 0.758 |
MST1 |
0.639 | -0.122 | 1 | 0.431 |
CK1A |
0.639 | -0.074 | -3 | 0.196 |
YANK3 |
0.638 | -0.021 | 2 | 0.448 |
TAO1 |
0.638 | 0.009 | 1 | 0.413 |
BIKE |
0.638 | -0.007 | 1 | 0.455 |
LIMK2_TYR |
0.635 | 0.178 | -3 | 0.526 |
OSR1 |
0.634 | -0.056 | 2 | 0.751 |
MYO3A |
0.631 | -0.029 | 1 | 0.439 |
TTK |
0.630 | -0.068 | -2 | 0.528 |
PKMYT1_TYR |
0.629 | 0.065 | 3 | 0.765 |
PDHK4_TYR |
0.629 | 0.025 | 2 | 0.837 |
MAP2K4_TYR |
0.628 | -0.010 | -1 | 0.705 |
TESK1_TYR |
0.628 | 0.019 | 3 | 0.784 |
MAP2K7_TYR |
0.628 | 0.028 | 2 | 0.820 |
AAK1 |
0.628 | 0.013 | 1 | 0.418 |
MAP2K6_TYR |
0.626 | -0.040 | -1 | 0.700 |
RET |
0.626 | 0.020 | 1 | 0.463 |
ASK1 |
0.625 | -0.105 | 1 | 0.426 |
BMPR2_TYR |
0.625 | -0.027 | -1 | 0.685 |
MST1R |
0.624 | 0.025 | 3 | 0.747 |
EPHA6 |
0.624 | -0.005 | -1 | 0.708 |
CSF1R |
0.623 | -0.004 | 3 | 0.738 |
PINK1_TYR |
0.622 | -0.085 | 1 | 0.504 |
ABL2 |
0.622 | 0.001 | -1 | 0.695 |
CK1G3 |
0.621 | -0.062 | -3 | 0.168 |
LIMK1_TYR |
0.621 | 0.010 | 2 | 0.807 |
EPHB4 |
0.620 | -0.019 | -1 | 0.718 |
ABL1 |
0.620 | -0.004 | -1 | 0.693 |
PDHK1_TYR |
0.620 | -0.100 | -1 | 0.706 |
JAK2 |
0.620 | -0.030 | 1 | 0.472 |
ALPHAK3 |
0.619 | -0.125 | -1 | 0.617 |
TYRO3 |
0.619 | -0.007 | 3 | 0.720 |
DDR1 |
0.617 | -0.017 | 4 | 0.690 |
TYK2 |
0.617 | -0.092 | 1 | 0.461 |
ROS1 |
0.617 | -0.024 | 3 | 0.696 |
TNK2 |
0.617 | 0.018 | 3 | 0.703 |
MERTK |
0.616 | 0.038 | 3 | 0.714 |
LCK |
0.616 | -0.021 | -1 | 0.710 |
YES1 |
0.615 | -0.032 | -1 | 0.710 |
HCK |
0.615 | -0.045 | -1 | 0.721 |
TXK |
0.614 | -0.013 | 1 | 0.405 |
FGFR2 |
0.614 | -0.016 | 3 | 0.725 |
TNK1 |
0.614 | 0.039 | 3 | 0.707 |
BLK |
0.614 | -0.016 | -1 | 0.707 |
KDR |
0.613 | -0.017 | 3 | 0.704 |
NEK10_TYR |
0.613 | -0.024 | 1 | 0.413 |
STLK3 |
0.612 | -0.131 | 1 | 0.401 |
FER |
0.612 | -0.090 | 1 | 0.458 |
JAK3 |
0.612 | -0.075 | 1 | 0.442 |
ITK |
0.612 | -0.034 | -1 | 0.718 |
AXL |
0.612 | 0.008 | 3 | 0.720 |
JAK1 |
0.612 | -0.016 | 1 | 0.424 |
KIT |
0.611 | -0.074 | 3 | 0.735 |
TNNI3K_TYR |
0.611 | 0.012 | 1 | 0.481 |
WEE1_TYR |
0.611 | -0.010 | -1 | 0.624 |
SRMS |
0.610 | -0.069 | 1 | 0.424 |
FGFR1 |
0.610 | -0.035 | 3 | 0.692 |
EPHB1 |
0.610 | -0.062 | 1 | 0.420 |
FGR |
0.610 | -0.117 | 1 | 0.452 |
FLT3 |
0.609 | -0.101 | 3 | 0.721 |
EPHA4 |
0.609 | -0.058 | 2 | 0.780 |
EPHB3 |
0.608 | -0.052 | -1 | 0.717 |
BMX |
0.608 | -0.030 | -1 | 0.655 |
BTK |
0.607 | -0.053 | -1 | 0.726 |
TEK |
0.607 | -0.014 | 3 | 0.660 |
EPHB2 |
0.607 | -0.072 | -1 | 0.709 |
EPHA1 |
0.607 | 0.011 | 3 | 0.725 |
PDGFRB |
0.606 | -0.102 | 3 | 0.730 |
FRK |
0.606 | -0.035 | -1 | 0.753 |
MET |
0.606 | -0.067 | 3 | 0.730 |
DDR2 |
0.605 | 0.024 | 3 | 0.669 |
TEC |
0.605 | -0.027 | -1 | 0.692 |
FGFR3 |
0.604 | -0.053 | 3 | 0.701 |
INSRR |
0.604 | -0.120 | 3 | 0.674 |
EPHA7 |
0.603 | -0.041 | 2 | 0.777 |
LTK |
0.603 | -0.043 | 3 | 0.666 |
PDGFRA |
0.603 | -0.101 | 3 | 0.722 |
CK1G2 |
0.602 | -0.083 | -3 | 0.222 |
FYN |
0.601 | -0.071 | -1 | 0.664 |
ALK |
0.601 | -0.062 | 3 | 0.639 |
FLT1 |
0.600 | -0.098 | -1 | 0.679 |
PTK2B |
0.600 | -0.023 | -1 | 0.684 |
YANK2 |
0.599 | -0.068 | 2 | 0.455 |
LYN |
0.599 | -0.081 | 3 | 0.652 |
ERBB2 |
0.598 | -0.116 | 1 | 0.421 |
FLT4 |
0.597 | -0.108 | 3 | 0.689 |
EPHA3 |
0.597 | -0.088 | 2 | 0.752 |
PTK6 |
0.595 | -0.131 | -1 | 0.655 |
MATK |
0.594 | -0.087 | -1 | 0.598 |
EPHA8 |
0.594 | -0.078 | -1 | 0.682 |
EPHA5 |
0.594 | -0.079 | 2 | 0.758 |
NTRK1 |
0.593 | -0.152 | -1 | 0.668 |
EGFR |
0.593 | -0.086 | 1 | 0.363 |
FGFR4 |
0.593 | -0.079 | -1 | 0.641 |
SRC |
0.591 | -0.094 | -1 | 0.669 |
CSK |
0.591 | -0.104 | 2 | 0.774 |
MUSK |
0.591 | -0.063 | 1 | 0.352 |
NTRK2 |
0.591 | -0.141 | 3 | 0.678 |
INSR |
0.590 | -0.136 | 3 | 0.661 |
NTRK3 |
0.590 | -0.112 | -1 | 0.630 |
PTK2 |
0.589 | -0.064 | -1 | 0.626 |
SYK |
0.588 | -0.090 | -1 | 0.620 |
EPHA2 |
0.586 | -0.077 | -1 | 0.668 |
ERBB4 |
0.582 | -0.085 | 1 | 0.366 |
ZAP70 |
0.578 | -0.061 | -1 | 0.543 |
IGF1R |
0.575 | -0.132 | 3 | 0.593 |
FES |
0.572 | -0.100 | -1 | 0.615 |