Motif 779 (n=284)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E7EWF7 | None | T85 | ochoa | Uncharacterized protein | None |
| H7C0C1 | None | T121 | ochoa | ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP synthase subunit O) (Oligomycin sensitivity conferral protein) | None |
| O00151 | PDLIM1 | T291 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O15061 | SYNM | T637 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15061 | SYNM | T1146 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15127 | SCAMP2 | T109 | ochoa | Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15360 | FANCA | T351 | psp | Fanconi anemia group A protein (Protein FACA) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
| O15446 | POLR1G | T238 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O15519 | CFLAR | T166 | psp | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:9880531}. |
| O43264 | ZW10 | T89 | ochoa | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| O43525 | KCNQ3 | T246 | psp | Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:16319223, PubMed:27564677, PubMed:28793216, PubMed:9872318). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:14534157, PubMed:16319223, PubMed:27564677, PubMed:9872318). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:16319223, PubMed:28793216). M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of M1 muscarinic acetylcholine receptors (PubMed:10713961). KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain (PubMed:11159685). {ECO:0000250|UniProtKB:O43526, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:16319223, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:9872318}. |
| O43526 | KCNQ2 | T217 | psp | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| O60343 | TBC1D4 | T488 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60814 | H2BC12 | T91 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O75362 | ZNF217 | T643 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75369 | FLNB | T913 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75419 | CDC45 | T262 | ochoa | Cell division control protein 45 homolog (PORC-PI-1) | Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| O75469 | NR1I2 | T408 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O75694 | NUP155 | T738 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O94885 | SASH1 | T824 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94887 | FARP2 | T28 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95149 | SNUPN | T341 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| O95271 | TNKS | T1128 | psp | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
| O95684 | CEP43 | T380 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| P04350 | TUBB4A | T232 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04406 | GAPDH | T177 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P04792 | HSPB1 | T180 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P04843 | RPN1 | T63 | ochoa | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39567208}. |
| P06733 | ENO1 | T376 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07437 | TUBB | T232 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07900 | HSP90AA1 | T713 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P09104 | ENO2 | T376 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
| P09884 | POLA1 | T404 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
| P12882 | MYH1 | T1650 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12931 | SRC | T182 | ochoa | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P12931 | SRC | T183 | ochoa | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P13535 | MYH8 | T1649 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13929 | ENO3 | T376 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P14618 | PKM | T409 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P18583 | SON | T1637 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19634 | SLC9A1 | T685 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P20823 | HNF1A | T74 | ochoa | Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:38018242}. |
| P22626 | HNRNPA2B1 | T145 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23396 | RPS3 | T42 | psp | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| P26196 | DDX6 | T38 | ochoa | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) | Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:25995375, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:31422817}. |
| P26368 | U2AF2 | T296 | ochoa | Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit) | Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186). {ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:21536736}. |
| P26599 | PTBP1 | T138 | psp | Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:21518806}. |
| P27816 | MAP4 | T526 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | T627 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28289 | TMOD1 | T54 | psp | Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:38168645, ECO:0000269|PubMed:8002995}. |
| P29972 | AQP1 | T239 | psp | Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel) | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}. |
| P30305 | CDC25B | T265 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30566 | ADSL | T239 | ochoa | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| P32241 | VIPR1 | T429 | psp | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P32298 | GRK4 | T256 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P32519 | ELF1 | T231 | psp | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P35222 | CTNNB1 | T120 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35573 | AGL | T334 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P35579 | MYH9 | T638 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | T1847 | psp | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P35609 | ACTN2 | T744 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P36952 | SERPINB5 | T310 | psp | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P41208 | CETN2 | T118 | psp | Centrin-2 (Caltractin isoform 1) | Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}. |
| P42166 | TMPO | T137 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42166 | TMPO | T138 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42858 | HTT | T269 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P43307 | SSR1 | T245 | ochoa | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. |
| P46013 | MKI67 | T1484 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1849 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2211 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P47755 | CAPZA2 | T63 | ochoa | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
| P47756 | CAPZB | T186 | psp | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| P48047 | ATP5PO | T121 | ochoa | ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP synthase subunit O) (Oligomycin sensitivity conferral protein) (OSCP) | Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13621, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P48681 | NES | T585 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48730 | CSNK1D | T161 | psp | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49790 | NUP153 | T224 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49915 | GMPS | T307 | ochoa | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. {ECO:0000269|PubMed:8089153}. |
| P51787 | KCNQ1 | T513 | psp | Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| P52209 | PGD | T35 | ochoa | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}. |
| P52597 | HNRNPF | T35 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P52732 | KIF11 | T923 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P52907 | CAPZA1 | T63 | ochoa | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| P54132 | BLM | T359 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54868 | HMGCS2 | T329 | ochoa | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}. |
| P56182 | RRP1 | T24 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
| P57053 | H2BC12L | T91 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | T91 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P61160 | ACTR2 | T237 | psp | Actin-related protein 2 (Actin-like protein 2) | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}. |
| P61247 | RPS3A | T88 | psp | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62807 | H2BC4 | T91 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P62879 | GNB2 | T31 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| P63244 | RACK1 | T96 | ochoa | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
| P68371 | TUBB4B | T232 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P99999 | CYCS | T50 | ochoa | Cytochrome c | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
| Q00610 | CLTC | T105 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q00613 | HSF1 | T142 | psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q00872 | MYBPC1 | T352 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q01167 | FOXK2 | T556 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02086 | SP2 | T229 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q02543 | RPL18A | T90 | ochoa | Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q06210 | GFPT1 | T569 | ochoa | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). {ECO:0000250|UniProtKB:P47856, ECO:0000269|PubMed:26887390}. |
| Q08043 | ACTN3 | T751 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q12888 | TP53BP1 | T696 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12988 | HSPB3 | T62 | ochoa | Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3) | Inhibitor of actin polymerization. |
| Q13085 | ACACA | T58 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13237 | PRKG2 | T607 | ochoa | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
| Q13761 | RUNX3 | T155 | psp | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13885 | TUBB2A | T232 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14157 | UBAP2L | T863 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14203 | DCTN1 | T1172 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14315 | FLNC | T1815 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | T2191 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14511 | NEDD9 | T804 | psp | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q14676 | MDC1 | T98 | psp | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14683 | SMC1A | T946 | ochoa | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q15149 | PLEC | T3581 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15208 | STK38 | T270 | psp | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}. |
| Q15233 | NONO | T151 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15375 | EPHA7 | T613 | ochoa | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
| Q15424 | SAFB | T78 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15438 | CYTH1 | T54 | ochoa | Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1) | Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:29420262, ECO:0000269|PubMed:9653114}. |
| Q16637 | SMN1 | T37 | ochoa | Survival motor neuron protein (Component of gems 1) (Gemin-1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9845364). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits (PubMed:17178713, PubMed:21816274, PubMed:22101937). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development (PubMed:23063131). Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:17178713, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:22101937, ECO:0000269|PubMed:23063131, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9845364}. |
| Q16665 | HIF1A | T63 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16778 | H2BC21 | T91 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q3MHD2 | LSM12 | T73 | ochoa | Protein LSM12 | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed:34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed:34362892). {ECO:0000269|PubMed:34362892}. |
| Q49A88 | CCDC14 | T365 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q5QNW6 | H2BC18 | T91 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5S007 | LRRK2 | T1343 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5S007 | LRRK2 | T1368 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5S007 | LRRK2 | T1491 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5S007 | LRRK2 | T2483 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5VST9 | OBSCN | T4788 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VTT5 | MYOM3 | T1143 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q5VVJ2 | MYSM1 | T226 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
| Q5VWN6 | TASOR2 | T1720 | ochoa | Protein TASOR 2 | None |
| Q6H8Q1 | ABLIM2 | T481 | ochoa | Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| Q6P1Q9 | METTL2B | T152 | ochoa | tRNA N(3)-cytidine methyltransferase METTL2B (EC 2.1.1.-) (Methyltransferase-like protein 2B) | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). {ECO:0000269|PubMed:28655767}. |
| Q76G19 | PDZD4 | T662 | ochoa | PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein) | None |
| Q7L5L3 | GDPD3 | T175 | psp | Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3) | Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q99LY2, ECO:0000269|PubMed:27637550}. |
| Q7L7X3 | TAOK1 | T502 | psp | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7L7X3 | TAOK1 | T785 | psp | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z2Z1 | TICRR | T1265 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z6J6 | FRMD5 | T400 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q86UX7 | FERMT3 | T340 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86XJ1 | GAS2L3 | T575 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q8IWB6 | TEX14 | T728 | psp | Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein) | Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). {ECO:0000250}. |
| Q8IX03 | WWC1 | T1006 | psp | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8N392 | ARHGAP18 | T154 | ochoa | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269|PubMed:21865595, ECO:0000269|PubMed:25778702}. |
| Q8NC56 | LEMD2 | T24 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8NEZ4 | KMT2C | T3693 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TBC4 | UBA3 | T403 | ochoa | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}. |
| Q8TDY4 | ASAP3 | T732 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1) | Promotes cell proliferation. {ECO:0000269|PubMed:14654939}. |
| Q8TEW0 | PARD3 | T833 | psp | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WVC0 | LEO1 | T496 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q92614 | MYO18A | T1008 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92783 | STAM | T201 | ochoa | Signal transducing adapter molecule 1 (STAM-1) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}. |
| Q92878 | RAD50 | T690 | ochoa | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q93079 | H2BC9 | T91 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q969P6 | TOP1MT | T406 | ochoa | DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1) | Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250, ECO:0000269|PubMed:11526219}. |
| Q969P6 | TOP1MT | T421 | ochoa | DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1) | Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250, ECO:0000269|PubMed:11526219}. |
| Q96FA3 | PELI1 | T288 | psp | E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12496252, PubMed:17675297, PubMed:29883609, PubMed:30952868). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12496252, PubMed:17675297). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (By similarity). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination (PubMed:30952868). Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753). {ECO:0000250|UniProtKB:Q8C669, ECO:0000269|PubMed:12496252, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:33215753}. |
| Q96HE9 | PRR11 | T287 | ochoa | Proline-rich protein 11 | Plays a critical role in cell cycle progression. {ECO:0000269|PubMed:23246489}. |
| Q96PM5 | RCHY1 | T217 | psp | RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19043414, PubMed:19483087). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603, ECO:0000269|PubMed:21994467, ECO:0000269|PubMed:33909987}.; FUNCTION: [Isoform 4]: Has no E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20452352}. |
| Q96Q42 | ALS2 | T512 | ochoa | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96T17 | MAP7D2 | T641 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q99460 | PSMD1 | T367 | ochoa | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q99523 | SORT1 | T812 | ochoa | Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) | Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}. |
| Q99547 | MPHOSPH6 | T124 | ochoa | M-phase phosphoprotein 6 | RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:26166824}. |
| Q99832 | CCT7 | T57 | psp | T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q99877 | H2BC15 | T91 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | T91 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | T91 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BQ70 | TCF25 | T102 | ochoa | Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}. |
| Q9BRK0 | REEP2 | T182 | ochoa | Receptor expression-enhancing protein 2 | Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:24388663}. |
| Q9BVA1 | TUBB2B | T232 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BVL2 | NUP58 | T328 | ochoa | Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}. |
| Q9BXS6 | NUSAP1 | T314 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9H497 | TOR3A | T362 | ochoa | Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) | None |
| Q9H501 | ESF1 | T319 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9H5Y7 | SLITRK6 | T739 | ochoa | SLIT and NTRK-like protein 6 | Regulator of neurite outgrowth required for normal hearing and vision. {ECO:0000269|PubMed:23543054}. |
| Q9H9S0 | NANOG | T280 | psp | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}. |
| Q9HAT8 | PELI2 | T290 | psp | E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. {ECO:0000269|PubMed:12804775, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:22669975}. |
| Q9HB71 | CACYBP | T72 | ochoa | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
| Q9HB71 | CACYBP | T183 | ochoa | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
| Q9HCE1 | MOV10 | T160 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9NQS1 | AVEN | T307 | ochoa | Cell death regulator Aven | Protects against apoptosis mediated by Apaf-1. |
| Q9NR31 | SAR1A | T164 | ochoa | Small COPII coat GTPase SAR1A (EC 3.6.5.2) (COPII-associated small GTPase) (Secretion-associated Ras-related GTPase 1A) | Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:23433038, PubMed:32358066, PubMed:36369712). The GTPase activity of SAR1 by controlling the timing of COPII budding regulates the size of the formed vesicles and is important for cargo selection depending on their size (PubMed:32358066). Together with SEC16A, forms the organized scaffold defining endoplasmic reticulum exit sites (ERES), some specific domains of the endoplasmic reticulum where COPII vesicles form (PubMed:17005010). In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B (PubMed:34290409). {ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:23433038, ECO:0000269|PubMed:32358066, ECO:0000269|PubMed:34290409, ECO:0000269|PubMed:36369712}. |
| Q9NV70 | EXOC1 | T509 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9NWQ8 | PAG1 | T183 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NYL9 | TMOD3 | T56 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NZM5 | NOP53 | T73 | ochoa | Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) | Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). {ECO:0000269|PubMed:15355975, ECO:0000269|PubMed:16971513, ECO:0000269|PubMed:21167305, ECO:0000269|PubMed:21741933, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:24556985, ECO:0000269|PubMed:25818168, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081, ECO:0000269|PubMed:27829214}. |
| Q9P265 | DIP2B | T1430 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P2T1 | GMPR2 | T187 | ochoa | GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469}. |
| Q9UEU0 | VTI1B | T184 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. {ECO:0000269|PubMed:23217709}. |
| Q9UIF9 | BAZ2A | T140 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UJX2 | CDC23 | T542 | ochoa | Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UKX2 | MYH2 | T792 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1652 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UN19 | DAPP1 | T119 | ochoa | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
| Q9UNA1 | ARHGAP26 | T577 | ochoa | Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) | GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058). {ECO:0000269|PubMed:27512058, ECO:0000269|PubMed:38081847}.; FUNCTION: [Isoform 2]: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. {ECO:0000269|PubMed:32344433}. |
| Q9UPQ7 | PDZRN3 | T959 | ochoa | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000250|UniProtKB:Q69ZS0}. |
| Q9Y277 | VDAC3 | T188 | ochoa | Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity). {ECO:0000250|UniProtKB:Q60931, ECO:0000269|PubMed:31935282}. |
| Q9Y295 | DRG1 | T101 | psp | Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-) | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155, ECO:0000269|PubMed:28855639, ECO:0000269|PubMed:29915238, ECO:0000269|PubMed:37179472}. |
| Q9Y2C9 | TLR6 | T399 | ochoa | Toll-like receptor 6 (CD antigen CD286) | Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584). {ECO:0000269|PubMed:11441107, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}. |
| Q9Y4D8 | HECTD4 | T3269 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4J8 | DTNA | T687 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y606 | PUS1 | T200 | ochoa | Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) | Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:15772074, PubMed:24722331). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:24722331). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:24722331). {ECO:0000269|PubMed:15772074, ECO:0000269|PubMed:24722331, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}. |
| Q9Y6D9 | MAD1L1 | T680 | psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q99613 | EIF3C | T880 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P60174 | TPI1 | T46 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P07858 | CTSB | T95 | Sugiyama | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}. |
| P08195 | SLC3A2 | T325 | Sugiyama | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P11586 | MTHFD1 | T527 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| P50991 | CCT4 | T69 | Sugiyama | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P53621 | COPA | T821 | Sugiyama | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| Q06830 | PRDX1 | T156 | Sugiyama | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q9NS23 | RASSF1 | T43 | PSP | Ras association domain-containing protein 1 | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}. |
| Q15293 | RCN1 | T101 | Sugiyama | Reticulocalbin-1 | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. |
| Q00610 | CLTC | T606 | SIGNOR|PSP | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| O15111 | CHUK | T584 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| Q9HC38 | GLOD4 | T249 | Sugiyama | Glyoxalase domain-containing protein 4 | None |
| O43283 | MAP3K13 | T421 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| O75506 | HSBP1 | T29 | Sugiyama | Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13) | Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. |
| P11586 | MTHFD1 | T380 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| Q9NYB9 | ABI2 | T24 | Sugiyama | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q8N6T3 | ARFGAP1 | T292 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q9NYU2 | UGGT1 | T724 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| O94804 | STK10 | T544 | Sugiyama | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| Q9Y597 | KCTD3 | T673 | Sugiyama | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| P42167 | TMPO | T137 | Sugiyama | Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P62269 | RPS18 | T69 | Sugiyama | Small ribosomal subunit protein uS13 (40S ribosomal protein S18) (Ke-3) (Ke3) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399}. |
| Q9Y230 | RUVBL2 | T199 | Sugiyama | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| P18124 | RPL7 | T196 | Sugiyama | Large ribosomal subunit protein uL30 (60S ribosomal protein L7) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). Binds to G-rich structures in 28S rRNA and in mRNAs (PubMed:12962325). Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (PubMed:12962325). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| O43164 | PJA2 | T200 | Sugiyama | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| Q6NVY1 | HIBCH | T249 | Sugiyama | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}. |
| Q9H814 | PHAX | T151 | Sugiyama | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| P16234 | PDGFRA | T740 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| O43747 | AP1G1 | T349 | Sugiyama | AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}. |
| Q12874 | SF3A3 | T131 | Sugiyama | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| Q16543 | CDC37 | T243 | Sugiyama | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. |
| O43776 | NARS1 | T503 | Sugiyama | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) | Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}. |
| P00505 | GOT2 | T403 | Sugiyama | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
| P30291 | WEE1 | T615 | Sugiyama | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P38646 | HSPA9 | T177 | Sugiyama | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| Q9H444 | CHMP4B | T103 | Sugiyama | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:33349255}.; FUNCTION: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861}. |
| O75223 | GGCT | T169 | Sugiyama | Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}. |
| Q01105 | SET | T126 | Sugiyama | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q2NKX8 | ERCC6L | T1202 | Sugiyama | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q12792 | TWF1 | T164 | Sugiyama | Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}. |
| Q6NUQ4 | TMEM214 | T55 | Sugiyama | Transmembrane protein 214 | Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress. {ECO:0000269|PubMed:23661706}. |
| Q12792 | TWF1 | T304 | Sugiyama | Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}. |
| P34932 | HSPA4 | T649 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P11142 | HSPA8 | T430 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P48643 | CCT5 | T69 | Sugiyama | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9Y3S1 | WNK2 | T2159 | Sugiyama | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| P41252 | IARS1 | T507 | Sugiyama | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| P51659 | HSD17B4 | T191 | Sugiyama | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P39687 | ANP32A | T126 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| Q14164 | IKBKE | T414 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| P10809 | HSPD1 | T114 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| O43707 | ACTN4 | T756 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P12814 | ACTN1 | T737 | Sugiyama | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| Q5S007 | LRRK2 | T1452 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| P24534 | EEF1B2 | T153 | Sugiyama | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
| Q92688 | ANP32B | T126 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| P62316 | SNRPD2 | T33 | Sugiyama | Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}. |
| Q9BS26 | ERP44 | T293 | Sugiyama | Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:14517240, PubMed:29858230). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230). {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240, ECO:0000269|PubMed:15652484, ECO:0000269|PubMed:29858230}. |
| Q86UE8 | TLK2 | T313 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q9UKI8 | TLK1 | T304 | Sugiyama | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q8NG66 | NEK11 | T19 | Sugiyama | Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}. |
| Q8TD19 | NEK9 | T67 | Sugiyama | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| O00566 | MPHOSPH10 | T332 | EPSD|PSP | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}. |
| Q99683 | MAP3K5 | T779 | Sugiyama | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q99759 | MAP3K3 | T384 | Sugiyama | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9H2G2 | SLK | T809 | Sugiyama | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2X6 | HIPK2 | T125 | Sugiyama | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H4B4 | PLK3 | T80 | Sugiyama | Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}. |
| Q9HBH9 | MKNK2 | T430 | Sugiyama | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Q13136 | PPFIA1 | T199 | Sugiyama | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q8N684 | CPSF7 | T161 | Sugiyama | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q9C0C2 | TNKS1BP1 | T204 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| P35579 | MYH9 | T309 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P46013 | MKI67 | T2093 | Sugiyama | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| Q99439 | CNN2 | T58 | Sugiyama | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 5.551115e-16 | 15.256 |
| R-HSA-68886 | M Phase | 4.440892e-15 | 14.353 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.996803e-15 | 14.398 |
| R-HSA-2262752 | Cellular responses to stress | 1.335154e-12 | 11.874 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.529776e-12 | 11.815 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.024930e-10 | 9.694 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.943194e-10 | 9.711 |
| R-HSA-1500931 | Cell-Cell communication | 3.438525e-10 | 9.464 |
| R-HSA-68875 | Mitotic Prophase | 4.223717e-10 | 9.374 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.934202e-10 | 9.159 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 8.270041e-10 | 9.082 |
| R-HSA-69481 | G2/M Checkpoints | 1.040023e-09 | 8.983 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.377836e-09 | 8.861 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.428146e-09 | 8.845 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.645910e-09 | 8.784 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.035299e-09 | 8.691 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.035299e-09 | 8.691 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.334416e-09 | 8.477 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.334416e-09 | 8.477 |
| R-HSA-5334118 | DNA methylation | 3.539722e-09 | 8.451 |
| R-HSA-912446 | Meiotic recombination | 4.183424e-09 | 8.378 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.414953e-09 | 8.266 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.291866e-09 | 8.276 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.190182e-09 | 8.208 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 7.644168e-09 | 8.117 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 9.739660e-09 | 8.011 |
| R-HSA-9710421 | Defective pyroptosis | 1.028762e-08 | 7.988 |
| R-HSA-446728 | Cell junction organization | 1.245427e-08 | 7.905 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.550764e-08 | 7.809 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.550764e-08 | 7.809 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.830092e-08 | 7.738 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.960782e-08 | 7.708 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.125951e-08 | 7.672 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.411039e-08 | 7.618 |
| R-HSA-211000 | Gene Silencing by RNA | 2.797060e-08 | 7.553 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.981632e-08 | 7.526 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.981632e-08 | 7.526 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.466118e-08 | 7.460 |
| R-HSA-73927 | Depurination | 3.668266e-08 | 7.436 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.248316e-08 | 7.280 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.471841e-08 | 7.262 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.471841e-08 | 7.262 |
| R-HSA-1221632 | Meiotic synapsis | 6.185230e-08 | 7.209 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.185230e-08 | 7.209 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 6.637096e-08 | 7.178 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.468449e-08 | 7.189 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 6.637096e-08 | 7.178 |
| R-HSA-1500620 | Meiosis | 7.376379e-08 | 7.132 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 8.528178e-08 | 7.069 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 9.640288e-08 | 7.016 |
| R-HSA-73928 | Depyrimidination | 9.640288e-08 | 7.016 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 9.763126e-08 | 7.010 |
| R-HSA-9609690 | HCMV Early Events | 1.053465e-07 | 6.977 |
| R-HSA-418990 | Adherens junctions interactions | 1.076742e-07 | 6.968 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.188155e-07 | 6.925 |
| R-HSA-774815 | Nucleosome assembly | 1.638292e-07 | 6.786 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.638292e-07 | 6.786 |
| R-HSA-421270 | Cell-cell junction organization | 1.938978e-07 | 6.712 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.331585e-07 | 6.632 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.399825e-07 | 6.620 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.040646e-07 | 6.517 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.650651e-07 | 6.438 |
| R-HSA-1474165 | Reproduction | 3.719735e-07 | 6.429 |
| R-HSA-157579 | Telomere Maintenance | 3.952703e-07 | 6.403 |
| R-HSA-68882 | Mitotic Anaphase | 4.255812e-07 | 6.371 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.530324e-07 | 6.344 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.508286e-07 | 6.346 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.830860e-07 | 6.316 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.337412e-07 | 6.273 |
| R-HSA-5693538 | Homology Directed Repair | 6.295848e-07 | 6.201 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.719304e-07 | 6.173 |
| R-HSA-9609646 | HCMV Infection | 7.584414e-07 | 6.120 |
| R-HSA-3214815 | HDACs deacetylate histones | 7.748840e-07 | 6.111 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.752270e-07 | 6.111 |
| R-HSA-2132295 | MHC class II antigen presentation | 9.697236e-07 | 6.013 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.394870e-06 | 5.855 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.524238e-06 | 5.817 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.744704e-06 | 5.758 |
| R-HSA-68877 | Mitotic Prometaphase | 1.827424e-06 | 5.738 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.966996e-06 | 5.706 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.169345e-06 | 5.664 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.270060e-06 | 5.644 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.272465e-06 | 5.644 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.353143e-06 | 5.628 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.447641e-06 | 5.611 |
| R-HSA-69306 | DNA Replication | 2.555636e-06 | 5.593 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.682071e-06 | 5.572 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.802811e-06 | 5.552 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.840191e-06 | 5.547 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.051059e-06 | 5.516 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.429551e-06 | 5.465 |
| R-HSA-5688426 | Deubiquitination | 3.881858e-06 | 5.411 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.282443e-06 | 5.368 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.935501e-06 | 5.405 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.347399e-06 | 5.362 |
| R-HSA-73886 | Chromosome Maintenance | 4.463419e-06 | 5.350 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.049442e-06 | 5.297 |
| R-HSA-69275 | G2/M Transition | 5.140348e-06 | 5.289 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.408259e-06 | 5.267 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.794710e-06 | 5.237 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.403306e-06 | 5.194 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.174067e-06 | 5.144 |
| R-HSA-195721 | Signaling by WNT | 8.499820e-06 | 5.071 |
| R-HSA-9020591 | Interleukin-12 signaling | 9.544116e-06 | 5.020 |
| R-HSA-392499 | Metabolism of proteins | 1.063087e-05 | 4.973 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.176373e-05 | 4.929 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.183734e-05 | 4.927 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.251484e-05 | 4.903 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.497338e-05 | 4.825 |
| R-HSA-199991 | Membrane Trafficking | 1.505350e-05 | 4.822 |
| R-HSA-9610379 | HCMV Late Events | 1.524541e-05 | 4.817 |
| R-HSA-977225 | Amyloid fiber formation | 1.559819e-05 | 4.807 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.643980e-05 | 4.784 |
| R-HSA-3214847 | HATs acetylate histones | 1.718410e-05 | 4.765 |
| R-HSA-70171 | Glycolysis | 1.865386e-05 | 4.729 |
| R-HSA-8939211 | ESR-mediated signaling | 2.165170e-05 | 4.665 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.603794e-05 | 4.584 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.775298e-05 | 4.557 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.775298e-05 | 4.557 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.944774e-05 | 4.531 |
| R-HSA-9663891 | Selective autophagy | 3.210061e-05 | 4.493 |
| R-HSA-422475 | Axon guidance | 3.347788e-05 | 4.475 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.572784e-05 | 4.447 |
| R-HSA-73884 | Base Excision Repair | 3.802450e-05 | 4.420 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.466011e-05 | 4.350 |
| R-HSA-9646399 | Aggrephagy | 5.302118e-05 | 4.276 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 5.395549e-05 | 4.268 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.421055e-05 | 4.266 |
| R-HSA-8852135 | Protein ubiquitination | 5.421569e-05 | 4.266 |
| R-HSA-2559583 | Cellular Senescence | 6.032524e-05 | 4.220 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.198688e-05 | 4.143 |
| R-HSA-191859 | snRNP Assembly | 7.276091e-05 | 4.138 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.276091e-05 | 4.138 |
| R-HSA-70326 | Glucose metabolism | 8.138634e-05 | 4.089 |
| R-HSA-157118 | Signaling by NOTCH | 8.685456e-05 | 4.061 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 9.158367e-05 | 4.038 |
| R-HSA-3371556 | Cellular response to heat stress | 1.056699e-04 | 3.976 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.479034e-05 | 4.023 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.814255e-05 | 4.008 |
| R-HSA-5617833 | Cilium Assembly | 1.004624e-04 | 3.998 |
| R-HSA-9675108 | Nervous system development | 9.555348e-05 | 4.020 |
| R-HSA-1280218 | Adaptive Immune System | 1.025182e-04 | 3.989 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.080772e-04 | 3.966 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.080772e-04 | 3.966 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.119496e-04 | 3.951 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.125410e-04 | 3.949 |
| R-HSA-8953854 | Metabolism of RNA | 1.214343e-04 | 3.916 |
| R-HSA-437239 | Recycling pathway of L1 | 1.392344e-04 | 3.856 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.429926e-04 | 3.845 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.444938e-04 | 3.840 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.444938e-04 | 3.840 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.444938e-04 | 3.840 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.728670e-04 | 3.762 |
| R-HSA-390522 | Striated Muscle Contraction | 1.748820e-04 | 3.757 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.931598e-04 | 3.714 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.048590e-04 | 3.689 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.215624e-04 | 3.655 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.615645e-04 | 3.582 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.615645e-04 | 3.582 |
| R-HSA-380287 | Centrosome maturation | 3.072907e-04 | 3.512 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.183275e-04 | 3.497 |
| R-HSA-597592 | Post-translational protein modification | 3.164212e-04 | 3.500 |
| R-HSA-373760 | L1CAM interactions | 3.387551e-04 | 3.470 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.789520e-04 | 3.421 |
| R-HSA-1632852 | Macroautophagy | 3.996175e-04 | 3.398 |
| R-HSA-9833482 | PKR-mediated signaling | 4.506924e-04 | 3.346 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.531783e-04 | 3.344 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.092911e-04 | 3.293 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.202566e-04 | 3.284 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 5.822268e-04 | 3.235 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 5.822268e-04 | 3.235 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.966279e-04 | 3.224 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.009348e-04 | 3.221 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 6.651511e-04 | 3.177 |
| R-HSA-190828 | Gap junction trafficking | 6.923478e-04 | 3.160 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 7.382631e-04 | 3.132 |
| R-HSA-168255 | Influenza Infection | 7.438468e-04 | 3.129 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.892747e-04 | 3.103 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.973621e-04 | 3.098 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.352502e-04 | 3.078 |
| R-HSA-9824446 | Viral Infection Pathways | 8.581392e-04 | 3.066 |
| R-HSA-9612973 | Autophagy | 8.746193e-04 | 3.058 |
| R-HSA-5218859 | Regulated Necrosis | 9.414689e-04 | 3.026 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.595297e-04 | 3.018 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.088518e-03 | 2.963 |
| R-HSA-9766229 | Degradation of CDH1 | 1.106107e-03 | 2.956 |
| R-HSA-391251 | Protein folding | 1.158011e-03 | 2.936 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 1.218753e-03 | 2.914 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.277815e-03 | 2.894 |
| R-HSA-190861 | Gap junction assembly | 1.515523e-03 | 2.819 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.284517e-03 | 2.891 |
| R-HSA-168256 | Immune System | 1.563615e-03 | 2.806 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.682365e-03 | 2.774 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.706636e-03 | 2.768 |
| R-HSA-373753 | Nephrin family interactions | 1.706636e-03 | 2.768 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.862302e-03 | 2.730 |
| R-HSA-73894 | DNA Repair | 1.889600e-03 | 2.724 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.892456e-03 | 2.723 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.048425e-03 | 2.689 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.132841e-03 | 2.671 |
| R-HSA-5357801 | Programmed Cell Death | 2.155648e-03 | 2.666 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.251040e-03 | 2.648 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.263856e-03 | 2.645 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.373024e-03 | 2.625 |
| R-HSA-983189 | Kinesins | 2.661804e-03 | 2.575 |
| R-HSA-3371568 | Attenuation phase | 2.725009e-03 | 2.565 |
| R-HSA-449147 | Signaling by Interleukins | 2.902618e-03 | 2.537 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.920838e-03 | 2.534 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.982359e-03 | 2.525 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.006512e-03 | 2.522 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.006512e-03 | 2.522 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.006512e-03 | 2.522 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.006512e-03 | 2.522 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.006512e-03 | 2.522 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.006512e-03 | 2.522 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.006512e-03 | 2.522 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.006512e-03 | 2.522 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.006512e-03 | 2.522 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.006512e-03 | 2.522 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.006512e-03 | 2.522 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.460066e-03 | 2.461 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 4.234525e-03 | 2.373 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 4.234525e-03 | 2.373 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.787264e-03 | 2.320 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.787264e-03 | 2.320 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.650560e-03 | 2.332 |
| R-HSA-5663205 | Infectious disease | 4.020025e-03 | 2.396 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.180153e-03 | 2.286 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 5.262645e-03 | 2.279 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.584358e-03 | 2.253 |
| R-HSA-70263 | Gluconeogenesis | 5.667754e-03 | 2.247 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.800886e-03 | 2.237 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.800886e-03 | 2.237 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.864191e-03 | 2.232 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.864191e-03 | 2.232 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.174625e-03 | 2.209 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 6.191977e-03 | 2.208 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 6.803756e-03 | 2.167 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 6.803756e-03 | 2.167 |
| R-HSA-3371571 | HSF1-dependent transactivation | 7.014449e-03 | 2.154 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 8.144409e-03 | 2.089 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 8.144409e-03 | 2.089 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.171011e-03 | 2.088 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 8.570138e-03 | 2.067 |
| R-HSA-4839726 | Chromatin organization | 8.577935e-03 | 2.067 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 8.875197e-03 | 2.052 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 8.875197e-03 | 2.052 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.460866e-03 | 2.024 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 9.647507e-03 | 2.016 |
| R-HSA-180746 | Nuclear import of Rev protein | 9.647507e-03 | 2.016 |
| R-HSA-177929 | Signaling by EGFR | 9.730724e-03 | 2.012 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.108603e-02 | 1.955 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.108603e-02 | 1.955 |
| R-HSA-3371511 | HSF1 activation | 1.132013e-02 | 1.946 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.132013e-02 | 1.946 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.132013e-02 | 1.946 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.222206e-02 | 1.913 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.272394e-02 | 1.895 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.316876e-02 | 1.880 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.737482e-02 | 1.760 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.737482e-02 | 1.760 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.416094e-02 | 1.849 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.519929e-02 | 1.818 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.519929e-02 | 1.818 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.599388e-02 | 1.796 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.670569e-02 | 1.777 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.819678e-02 | 1.740 |
| R-HSA-156902 | Peptide chain elongation | 1.398480e-02 | 1.854 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.425779e-02 | 1.846 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.628443e-02 | 1.788 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.646590e-02 | 1.783 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.646590e-02 | 1.783 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.425779e-02 | 1.846 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.734866e-02 | 1.761 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.519929e-02 | 1.818 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.519929e-02 | 1.818 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.628443e-02 | 1.788 |
| R-HSA-74160 | Gene expression (Transcription) | 1.753751e-02 | 1.756 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.416094e-02 | 1.849 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.826163e-02 | 1.738 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.747060e-02 | 1.758 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.745963e-02 | 1.758 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.398543e-02 | 1.854 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.900766e-02 | 1.721 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.907176e-02 | 1.720 |
| R-HSA-69242 | S Phase | 1.946271e-02 | 1.711 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 1.973741e-02 | 1.705 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 1.973741e-02 | 1.705 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 1.973741e-02 | 1.705 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 1.973741e-02 | 1.705 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 1.973741e-02 | 1.705 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 1.973741e-02 | 1.705 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.977120e-02 | 1.704 |
| R-HSA-72766 | Translation | 1.986875e-02 | 1.702 |
| R-HSA-162582 | Signal Transduction | 2.005057e-02 | 1.698 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.059352e-02 | 1.686 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.167699e-02 | 1.664 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.193331e-02 | 1.659 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.203215e-02 | 1.657 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.243185e-02 | 1.649 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.243185e-02 | 1.649 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.243185e-02 | 1.649 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.243185e-02 | 1.649 |
| R-HSA-69206 | G1/S Transition | 2.347555e-02 | 1.629 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.374525e-02 | 1.624 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.380908e-02 | 1.623 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.380908e-02 | 1.623 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.380908e-02 | 1.623 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.416154e-02 | 1.617 |
| R-HSA-5218900 | CASP8 activity is inhibited | 2.437907e-02 | 1.613 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 2.437907e-02 | 1.613 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.505377e-02 | 1.601 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.523651e-02 | 1.598 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.601723e-02 | 1.585 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.601723e-02 | 1.585 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.645169e-02 | 1.578 |
| R-HSA-5620924 | Intraflagellar transport | 2.671447e-02 | 1.573 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.687830e-02 | 1.571 |
| R-HSA-192823 | Viral mRNA Translation | 2.801737e-02 | 1.553 |
| R-HSA-111458 | Formation of apoptosome | 2.824379e-02 | 1.549 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 2.824379e-02 | 1.549 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.905447e-02 | 1.537 |
| R-HSA-109581 | Apoptosis | 2.948665e-02 | 1.530 |
| R-HSA-1266738 | Developmental Biology | 3.072731e-02 | 1.512 |
| R-HSA-9659379 | Sensory processing of sound | 3.143652e-02 | 1.503 |
| R-HSA-72312 | rRNA processing | 3.153366e-02 | 1.501 |
| R-HSA-212436 | Generic Transcription Pathway | 3.215817e-02 | 1.493 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 3.233578e-02 | 1.490 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.369018e-02 | 1.472 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.487151e-02 | 1.458 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.534495e-02 | 1.452 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.553655e-02 | 1.449 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.582154e-02 | 1.446 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 3.664464e-02 | 1.436 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 3.664464e-02 | 1.436 |
| R-HSA-72649 | Translation initiation complex formation | 3.665769e-02 | 1.436 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.953266e-02 | 1.403 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.953266e-02 | 1.403 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.038570e-02 | 1.394 |
| R-HSA-75893 | TNF signaling | 4.038570e-02 | 1.394 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 4.116026e-02 | 1.386 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 4.116026e-02 | 1.386 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.313821e-02 | 1.365 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.402693e-02 | 1.356 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.402693e-02 | 1.356 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.432144e-02 | 1.353 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.683042e-02 | 1.329 |
| R-HSA-1643685 | Disease | 4.744119e-02 | 1.324 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.805472e-02 | 1.236 |
| R-HSA-4085023 | Defective GFPT1 causes CMSTA1 | 5.805472e-02 | 1.236 |
| R-HSA-9916722 | 3-hydroxyisobutyryl-CoA hydrolase deficiency | 5.805472e-02 | 1.236 |
| R-HSA-5545619 | XAV939 stabilizes AXIN | 5.805472e-02 | 1.236 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.805472e-02 | 1.236 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 7.206887e-02 | 1.142 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 7.206887e-02 | 1.142 |
| R-HSA-1296072 | Voltage gated Potassium channels | 5.889384e-02 | 1.230 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.685331e-02 | 1.175 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 6.109919e-02 | 1.214 |
| R-HSA-4641257 | Degradation of AXIN | 5.889384e-02 | 1.230 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.320019e-02 | 1.135 |
| R-HSA-418885 | DCC mediated attractive signaling | 5.585137e-02 | 1.253 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 5.805472e-02 | 1.236 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.880213e-02 | 1.162 |
| R-HSA-5260271 | Diseases of Immune System | 6.880213e-02 | 1.162 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 7.226228e-02 | 1.141 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 6.109919e-02 | 1.214 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.971989e-02 | 1.303 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.061389e-02 | 1.296 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.480883e-02 | 1.188 |
| R-HSA-196780 | Biotin transport and metabolism | 5.585137e-02 | 1.253 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 5.585137e-02 | 1.253 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 5.585137e-02 | 1.253 |
| R-HSA-373755 | Semaphorin interactions | 5.506685e-02 | 1.259 |
| R-HSA-112316 | Neuronal System | 6.792339e-02 | 1.168 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.506685e-02 | 1.259 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.281467e-02 | 1.277 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 5.585137e-02 | 1.253 |
| R-HSA-9827857 | Specification of primordial germ cells | 7.206887e-02 | 1.142 |
| R-HSA-201556 | Signaling by ALK | 6.541980e-02 | 1.184 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.524539e-02 | 1.258 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.309539e-02 | 1.200 |
| R-HSA-913531 | Interferon Signaling | 6.393269e-02 | 1.194 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.330257e-02 | 1.135 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.447487e-02 | 1.128 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 7.664971e-02 | 1.115 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.760869e-02 | 1.110 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 7.777430e-02 | 1.109 |
| R-HSA-111471 | Apoptotic factor-mediated response | 7.777430e-02 | 1.109 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 7.777430e-02 | 1.109 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 7.777430e-02 | 1.109 |
| R-HSA-180292 | GAB1 signalosome | 7.777430e-02 | 1.109 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 7.777430e-02 | 1.109 |
| R-HSA-4086398 | Ca2+ pathway | 8.035991e-02 | 1.095 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 8.361627e-02 | 1.078 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.513557e-02 | 1.070 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 8.958720e-02 | 1.048 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 8.958720e-02 | 1.048 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.958720e-02 | 1.048 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 8.958720e-02 | 1.048 |
| R-HSA-9629569 | Protein hydroxylation | 8.958720e-02 | 1.048 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 8.958720e-02 | 1.048 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 8.958720e-02 | 1.048 |
| R-HSA-6807004 | Negative regulation of MET activity | 8.958720e-02 | 1.048 |
| R-HSA-9824272 | Somitogenesis | 9.068194e-02 | 1.042 |
| R-HSA-69239 | Synthesis of DNA | 9.166646e-02 | 1.038 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.225264e-02 | 1.035 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 9.457952e-02 | 1.024 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 9.487873e-02 | 1.023 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 9.487873e-02 | 1.023 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 9.567978e-02 | 1.019 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 9.567978e-02 | 1.019 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.569480e-02 | 1.019 |
| R-HSA-397014 | Muscle contraction | 9.569480e-02 | 1.019 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.792748e-02 | 1.009 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 9.854481e-02 | 1.006 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.018869e-01 | 0.992 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.054498e-01 | 0.977 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 1.127490e-01 | 0.948 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.474411e-01 | 0.831 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.474411e-01 | 0.831 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.474411e-01 | 0.831 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.642767e-01 | 0.784 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.807809e-01 | 0.743 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 1.807809e-01 | 0.743 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.807809e-01 | 0.743 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.969601e-01 | 0.706 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.969601e-01 | 0.706 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.969601e-01 | 0.706 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.969601e-01 | 0.706 |
| R-HSA-196025 | Formation of annular gap junctions | 1.969601e-01 | 0.706 |
| R-HSA-9613354 | Lipophagy | 2.128207e-01 | 0.672 |
| R-HSA-190873 | Gap junction degradation | 2.128207e-01 | 0.672 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.128207e-01 | 0.672 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.082017e-01 | 0.966 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.277270e-01 | 0.894 |
| R-HSA-8949613 | Cristae formation | 1.411664e-01 | 0.850 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.548900e-01 | 0.810 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.548900e-01 | 0.810 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.193323e-01 | 0.923 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.236710e-01 | 0.908 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.236710e-01 | 0.908 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.325164e-01 | 0.878 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.370200e-01 | 0.863 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.202981e-01 | 0.920 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.202981e-01 | 0.920 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.364785e-01 | 0.865 |
| R-HSA-72172 | mRNA Splicing | 1.631571e-01 | 0.787 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.344084e-01 | 0.872 |
| R-HSA-186763 | Downstream signal transduction | 1.688555e-01 | 0.772 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.302675e-01 | 0.885 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.807809e-01 | 0.743 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.796863e-01 | 0.745 |
| R-HSA-354192 | Integrin signaling | 1.830230e-01 | 0.737 |
| R-HSA-191650 | Regulation of gap junction activity | 1.127490e-01 | 0.948 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.969601e-01 | 0.706 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.098807e-01 | 0.678 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.098807e-01 | 0.678 |
| R-HSA-69190 | DNA strand elongation | 1.759164e-01 | 0.755 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.901709e-01 | 0.721 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 1.618451e-01 | 0.791 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.344084e-01 | 0.872 |
| R-HSA-392518 | Signal amplification | 1.973556e-01 | 0.705 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 1.127490e-01 | 0.948 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.642767e-01 | 0.784 |
| R-HSA-8849473 | PTK6 Expression | 1.807809e-01 | 0.743 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.830230e-01 | 0.737 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.830230e-01 | 0.737 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.150520e-01 | 0.939 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 1.302675e-01 | 0.885 |
| R-HSA-6798695 | Neutrophil degranulation | 1.628024e-01 | 0.788 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 1.211281e-01 | 0.917 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.973556e-01 | 0.705 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 1.302675e-01 | 0.885 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.474411e-01 | 0.831 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.642767e-01 | 0.784 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.344084e-01 | 0.872 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.688555e-01 | 0.772 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.901709e-01 | 0.721 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.973556e-01 | 0.705 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.280662e-01 | 0.893 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.097290e-01 | 0.678 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.618451e-01 | 0.791 |
| R-HSA-5205647 | Mitophagy | 1.973556e-01 | 0.705 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.047693e-01 | 0.689 |
| R-HSA-9620244 | Long-term potentiation | 1.277270e-01 | 0.894 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.548900e-01 | 0.810 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.344084e-01 | 0.872 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.062262e-01 | 0.686 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.062262e-01 | 0.686 |
| R-HSA-9664407 | Parasite infection | 2.062262e-01 | 0.686 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.177766e-01 | 0.929 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.618451e-01 | 0.791 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.150520e-01 | 0.939 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.747820e-01 | 0.758 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.830230e-01 | 0.737 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.747820e-01 | 0.758 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.747820e-01 | 0.758 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.759164e-01 | 0.755 |
| R-HSA-194138 | Signaling by VEGF | 1.500701e-01 | 0.824 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.650713e-01 | 0.782 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.602816e-01 | 0.795 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 1.302675e-01 | 0.885 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.969601e-01 | 0.706 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.759164e-01 | 0.755 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.045730e-01 | 0.689 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.045730e-01 | 0.689 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.211281e-01 | 0.917 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.557499e-01 | 0.808 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.296036e-01 | 0.887 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.045730e-01 | 0.689 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.904351e-01 | 0.720 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.830230e-01 | 0.737 |
| R-HSA-182971 | EGFR downregulation | 1.688555e-01 | 0.772 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.047693e-01 | 0.689 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 1.302675e-01 | 0.885 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 1.474411e-01 | 0.831 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.807809e-01 | 0.743 |
| R-HSA-418886 | Netrin mediated repulsion signals | 1.807809e-01 | 0.743 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 1.807809e-01 | 0.743 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.969601e-01 | 0.706 |
| R-HSA-176974 | Unwinding of DNA | 2.128207e-01 | 0.672 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.411664e-01 | 0.850 |
| R-HSA-420092 | Glucagon-type ligand receptors | 1.548900e-01 | 0.810 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 1.618451e-01 | 0.791 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.118189e-01 | 0.674 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.548900e-01 | 0.810 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.865663e-01 | 0.729 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 2.128207e-01 | 0.672 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.269698e-01 | 0.896 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.985994e-01 | 0.702 |
| R-HSA-180786 | Extension of Telomeres | 1.508347e-01 | 0.821 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.474411e-01 | 0.831 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.474411e-01 | 0.831 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.474411e-01 | 0.831 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.807809e-01 | 0.743 |
| R-HSA-447041 | CHL1 interactions | 1.807809e-01 | 0.743 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.969601e-01 | 0.706 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 2.128207e-01 | 0.672 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 2.128207e-01 | 0.672 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.411664e-01 | 0.850 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.901709e-01 | 0.721 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.973556e-01 | 0.705 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.973556e-01 | 0.705 |
| R-HSA-169911 | Regulation of Apoptosis | 2.045730e-01 | 0.689 |
| R-HSA-1296071 | Potassium Channels | 1.670742e-01 | 0.777 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.104238e-01 | 0.957 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.340294e-01 | 0.873 |
| R-HSA-109582 | Hemostasis | 1.856595e-01 | 0.731 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.045730e-01 | 0.689 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.555355e-01 | 0.808 |
| R-HSA-75158 | TRAIL signaling | 1.474411e-01 | 0.831 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.474411e-01 | 0.831 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 2.128207e-01 | 0.672 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.236710e-01 | 0.908 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.236717e-01 | 0.908 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.013392e-01 | 0.696 |
| R-HSA-73887 | Death Receptor Signaling | 1.320223e-01 | 0.879 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 1.474411e-01 | 0.831 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.969601e-01 | 0.706 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.618451e-01 | 0.791 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.901709e-01 | 0.721 |
| R-HSA-9711097 | Cellular response to starvation | 1.424100e-01 | 0.846 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 1.082017e-01 | 0.966 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.969601e-01 | 0.706 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.128207e-01 | 0.672 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.169652e-01 | 0.932 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.047693e-01 | 0.689 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.415753e-01 | 0.849 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.211281e-01 | 0.917 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.211281e-01 | 0.917 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.618451e-01 | 0.791 |
| R-HSA-114608 | Platelet degranulation | 1.563092e-01 | 0.806 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.411664e-01 | 0.850 |
| R-HSA-5620971 | Pyroptosis | 1.479954e-01 | 0.830 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.277270e-01 | 0.894 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.244796e-01 | 0.905 |
| R-HSA-162906 | HIV Infection | 1.239004e-01 | 0.907 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.105126e-01 | 0.957 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.699031e-01 | 0.770 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.789540e-01 | 0.747 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.759164e-01 | 0.755 |
| R-HSA-72306 | tRNA processing | 1.786085e-01 | 0.748 |
| R-HSA-9679506 | SARS-CoV Infections | 1.794856e-01 | 0.746 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.108607e-01 | 0.676 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.149949e-01 | 0.668 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.149949e-01 | 0.668 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.167920e-01 | 0.664 |
| R-HSA-4641258 | Degradation of DVL | 2.190895e-01 | 0.659 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.190895e-01 | 0.659 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.191514e-01 | 0.659 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.201860e-01 | 0.657 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.263809e-01 | 0.645 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.263809e-01 | 0.645 |
| R-HSA-202403 | TCR signaling | 2.275282e-01 | 0.643 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.283691e-01 | 0.641 |
| R-HSA-68952 | DNA replication initiation | 2.283691e-01 | 0.641 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.283691e-01 | 0.641 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.283691e-01 | 0.641 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 2.283691e-01 | 0.641 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 2.283691e-01 | 0.641 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.336896e-01 | 0.631 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.336896e-01 | 0.631 |
| R-HSA-69541 | Stabilization of p53 | 2.336896e-01 | 0.631 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.336896e-01 | 0.631 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.356483e-01 | 0.628 |
| R-HSA-5689603 | UCH proteinases | 2.358286e-01 | 0.627 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.359851e-01 | 0.627 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.384075e-01 | 0.623 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.410119e-01 | 0.618 |
| R-HSA-9758941 | Gastrulation | 2.420674e-01 | 0.616 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.436113e-01 | 0.613 |
| R-HSA-192905 | vRNP Assembly | 2.436113e-01 | 0.613 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.436113e-01 | 0.613 |
| R-HSA-210990 | PECAM1 interactions | 2.436113e-01 | 0.613 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.436113e-01 | 0.613 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.445160e-01 | 0.612 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.463632e-01 | 0.608 |
| R-HSA-4086400 | PCP/CE pathway | 2.463632e-01 | 0.608 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.483446e-01 | 0.605 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.483446e-01 | 0.605 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 2.483446e-01 | 0.605 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.483446e-01 | 0.605 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.483446e-01 | 0.605 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.516582e-01 | 0.599 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.556844e-01 | 0.592 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.556844e-01 | 0.592 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.556844e-01 | 0.592 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.556844e-01 | 0.592 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.556844e-01 | 0.592 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.556844e-01 | 0.592 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.569698e-01 | 0.590 |
| R-HSA-6806834 | Signaling by MET | 2.569698e-01 | 0.590 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 2.585533e-01 | 0.587 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.585533e-01 | 0.587 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.585533e-01 | 0.587 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.585533e-01 | 0.587 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.585533e-01 | 0.587 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.585533e-01 | 0.587 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.585533e-01 | 0.587 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.630281e-01 | 0.580 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.661277e-01 | 0.575 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.703728e-01 | 0.568 |
| R-HSA-162587 | HIV Life Cycle | 2.718515e-01 | 0.566 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.732010e-01 | 0.564 |
| R-HSA-69091 | Polymerase switching | 2.732010e-01 | 0.564 |
| R-HSA-69109 | Leading Strand Synthesis | 2.732010e-01 | 0.564 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.732010e-01 | 0.564 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.732010e-01 | 0.564 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.732010e-01 | 0.564 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.732010e-01 | 0.564 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.732010e-01 | 0.564 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.732010e-01 | 0.564 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.732010e-01 | 0.564 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.732010e-01 | 0.564 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.732010e-01 | 0.564 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.732010e-01 | 0.564 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.732010e-01 | 0.564 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.732010e-01 | 0.564 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.732010e-01 | 0.564 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.748707e-01 | 0.561 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.748707e-01 | 0.561 |
| R-HSA-373752 | Netrin-1 signaling | 2.777156e-01 | 0.556 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.777156e-01 | 0.556 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.777156e-01 | 0.556 |
| R-HSA-9907900 | Proteasome assembly | 2.777156e-01 | 0.556 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.777156e-01 | 0.556 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.850536e-01 | 0.545 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 2.850536e-01 | 0.545 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.850536e-01 | 0.545 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.850536e-01 | 0.545 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.854365e-01 | 0.544 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.875603e-01 | 0.541 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.875603e-01 | 0.541 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.875603e-01 | 0.541 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.880724e-01 | 0.540 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.880724e-01 | 0.540 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.891145e-01 | 0.539 |
| R-HSA-9675135 | Diseases of DNA repair | 2.923843e-01 | 0.534 |
| R-HSA-75153 | Apoptotic execution phase | 2.923843e-01 | 0.534 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.942499e-01 | 0.531 |
| R-HSA-69166 | Removal of the Flap Intermediate | 3.016367e-01 | 0.521 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 3.016367e-01 | 0.521 |
| R-HSA-418457 | cGMP effects | 3.016367e-01 | 0.521 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 3.016367e-01 | 0.521 |
| R-HSA-1433559 | Regulation of KIT signaling | 3.016367e-01 | 0.521 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 3.016367e-01 | 0.521 |
| R-HSA-5578768 | Physiological factors | 3.016367e-01 | 0.521 |
| R-HSA-6814848 | Glycerophospholipid catabolism | 3.016367e-01 | 0.521 |
| R-HSA-9856872 | Malate-aspartate shuttle | 3.016367e-01 | 0.521 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 3.016367e-01 | 0.521 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 3.016367e-01 | 0.521 |
| R-HSA-391160 | Signal regulatory protein family interactions | 3.016367e-01 | 0.521 |
| R-HSA-9634597 | GPER1 signaling | 3.070133e-01 | 0.513 |
| R-HSA-5619102 | SLC transporter disorders | 3.100795e-01 | 0.509 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.143068e-01 | 0.503 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.143068e-01 | 0.503 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 3.154359e-01 | 0.501 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 3.154359e-01 | 0.501 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 3.154359e-01 | 0.501 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 3.154359e-01 | 0.501 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 3.154359e-01 | 0.501 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 3.154359e-01 | 0.501 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 3.154359e-01 | 0.501 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 3.154359e-01 | 0.501 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.154359e-01 | 0.501 |
| R-HSA-171007 | p38MAPK events | 3.154359e-01 | 0.501 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.154359e-01 | 0.501 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 3.154359e-01 | 0.501 |
| R-HSA-8876725 | Protein methylation | 3.154359e-01 | 0.501 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 3.154359e-01 | 0.501 |
| R-HSA-9823739 | Formation of the anterior neural plate | 3.154359e-01 | 0.501 |
| R-HSA-202424 | Downstream TCR signaling | 3.161237e-01 | 0.500 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.215354e-01 | 0.493 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.215834e-01 | 0.493 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.288408e-01 | 0.483 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.289632e-01 | 0.483 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.289632e-01 | 0.483 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 3.289632e-01 | 0.483 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.289632e-01 | 0.483 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 3.289632e-01 | 0.483 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.289632e-01 | 0.483 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.289632e-01 | 0.483 |
| R-HSA-9945266 | Differentiation of T cells | 3.289632e-01 | 0.483 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 3.289632e-01 | 0.483 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.294783e-01 | 0.482 |
| R-HSA-72187 | mRNA 3'-end processing | 3.360769e-01 | 0.474 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.360769e-01 | 0.474 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.360769e-01 | 0.474 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 3.422240e-01 | 0.466 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 3.422240e-01 | 0.466 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 3.422240e-01 | 0.466 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.422240e-01 | 0.466 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.422240e-01 | 0.466 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.422240e-01 | 0.466 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.422240e-01 | 0.466 |
| R-HSA-5576893 | Phase 2 - plateau phase | 3.422240e-01 | 0.466 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.422240e-01 | 0.466 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.422240e-01 | 0.466 |
| R-HSA-432047 | Passive transport by Aquaporins | 3.422240e-01 | 0.466 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 3.422240e-01 | 0.466 |
| R-HSA-8956320 | Nucleotide biosynthesis | 3.432897e-01 | 0.464 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.450837e-01 | 0.462 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.485835e-01 | 0.458 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.518022e-01 | 0.454 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.552236e-01 | 0.449 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.552236e-01 | 0.449 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.552236e-01 | 0.449 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.552236e-01 | 0.449 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.552236e-01 | 0.449 |
| R-HSA-2028269 | Signaling by Hippo | 3.552236e-01 | 0.449 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.576383e-01 | 0.447 |
| R-HSA-163685 | Integration of energy metabolism | 3.640045e-01 | 0.439 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.647704e-01 | 0.438 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.647704e-01 | 0.438 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.647704e-01 | 0.438 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 3.679670e-01 | 0.434 |
| R-HSA-3928664 | Ephrin signaling | 3.679670e-01 | 0.434 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.679670e-01 | 0.434 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 3.679670e-01 | 0.434 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.679670e-01 | 0.434 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.679670e-01 | 0.434 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.679670e-01 | 0.434 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.684897e-01 | 0.434 |
| R-HSA-190236 | Signaling by FGFR | 3.701478e-01 | 0.432 |
| R-HSA-6807070 | PTEN Regulation | 3.774543e-01 | 0.423 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.804594e-01 | 0.420 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 3.804594e-01 | 0.420 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.804594e-01 | 0.420 |
| R-HSA-9834899 | Specification of the neural plate border | 3.804594e-01 | 0.420 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.804594e-01 | 0.420 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.804594e-01 | 0.420 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 3.804594e-01 | 0.420 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 3.804594e-01 | 0.420 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.859784e-01 | 0.413 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.859784e-01 | 0.413 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.927056e-01 | 0.406 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.927056e-01 | 0.406 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.927056e-01 | 0.406 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.927056e-01 | 0.406 |
| R-HSA-9823730 | Formation of definitive endoderm | 3.927056e-01 | 0.406 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 3.927056e-01 | 0.406 |
| R-HSA-379724 | tRNA Aminoacylation | 3.929799e-01 | 0.406 |
| R-HSA-351202 | Metabolism of polyamines | 3.929799e-01 | 0.406 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.999452e-01 | 0.398 |
| R-HSA-445717 | Aquaporin-mediated transport | 3.999452e-01 | 0.398 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.999452e-01 | 0.398 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.022304e-01 | 0.396 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 4.047105e-01 | 0.393 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 4.047105e-01 | 0.393 |
| R-HSA-69186 | Lagging Strand Synthesis | 4.047105e-01 | 0.393 |
| R-HSA-202040 | G-protein activation | 4.047105e-01 | 0.393 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 4.047105e-01 | 0.393 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 4.047105e-01 | 0.393 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 4.047105e-01 | 0.393 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 4.047105e-01 | 0.393 |
| R-HSA-167044 | Signalling to RAS | 4.047105e-01 | 0.393 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 4.047105e-01 | 0.393 |
| R-HSA-210991 | Basigin interactions | 4.047105e-01 | 0.393 |
| R-HSA-186797 | Signaling by PDGF | 4.068730e-01 | 0.391 |
| R-HSA-1268020 | Mitochondrial protein import | 4.068730e-01 | 0.391 |
| R-HSA-8848021 | Signaling by PTK6 | 4.137621e-01 | 0.383 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.137621e-01 | 0.383 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 4.164788e-01 | 0.380 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 4.164788e-01 | 0.380 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 4.164788e-01 | 0.380 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 4.164788e-01 | 0.380 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 4.164788e-01 | 0.380 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 4.164788e-01 | 0.380 |
| R-HSA-174403 | Glutathione synthesis and recycling | 4.164788e-01 | 0.380 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 4.164788e-01 | 0.380 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 4.280151e-01 | 0.369 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 4.280151e-01 | 0.369 |
| R-HSA-9669938 | Signaling by KIT in disease | 4.280151e-01 | 0.369 |
| R-HSA-8964038 | LDL clearance | 4.280151e-01 | 0.369 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 4.280151e-01 | 0.369 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.286094e-01 | 0.368 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.308498e-01 | 0.366 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.338218e-01 | 0.363 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.338372e-01 | 0.363 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.393241e-01 | 0.357 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 4.393241e-01 | 0.357 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 4.393241e-01 | 0.357 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 4.393241e-01 | 0.357 |
| R-HSA-200425 | Carnitine shuttle | 4.393241e-01 | 0.357 |
| R-HSA-74182 | Ketone body metabolism | 4.393241e-01 | 0.357 |
| R-HSA-3000170 | Syndecan interactions | 4.393241e-01 | 0.357 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.393241e-01 | 0.357 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.409082e-01 | 0.356 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.487739e-01 | 0.348 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 4.504101e-01 | 0.346 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.504101e-01 | 0.346 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.504101e-01 | 0.346 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 4.504101e-01 | 0.346 |
| R-HSA-429947 | Deadenylation of mRNA | 4.504101e-01 | 0.346 |
| R-HSA-9865881 | Complex III assembly | 4.504101e-01 | 0.346 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 4.542211e-01 | 0.343 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.545666e-01 | 0.342 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.608093e-01 | 0.336 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 4.612777e-01 | 0.336 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 4.612777e-01 | 0.336 |
| R-HSA-1296059 | G protein gated Potassium channels | 4.612777e-01 | 0.336 |
| R-HSA-9839394 | TGFBR3 expression | 4.612777e-01 | 0.336 |
| R-HSA-420029 | Tight junction interactions | 4.612777e-01 | 0.336 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.612777e-01 | 0.336 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 4.612777e-01 | 0.336 |
| R-HSA-2160916 | Hyaluronan degradation | 4.612777e-01 | 0.336 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.612777e-01 | 0.336 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 4.612777e-01 | 0.336 |
| R-HSA-9830364 | Formation of the nephric duct | 4.612777e-01 | 0.336 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.612777e-01 | 0.336 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 4.612777e-01 | 0.336 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.657837e-01 | 0.332 |
| R-HSA-8978934 | Metabolism of cofactors | 4.673511e-01 | 0.330 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.673511e-01 | 0.330 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.673511e-01 | 0.330 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.699050e-01 | 0.328 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.699050e-01 | 0.328 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 4.719309e-01 | 0.326 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.719309e-01 | 0.326 |
| R-HSA-8874081 | MET activates PTK2 signaling | 4.719309e-01 | 0.326 |
| R-HSA-525793 | Myogenesis | 4.719309e-01 | 0.326 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.719309e-01 | 0.326 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 4.719309e-01 | 0.326 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.744018e-01 | 0.324 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.823742e-01 | 0.317 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.823742e-01 | 0.317 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 4.823742e-01 | 0.317 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.823742e-01 | 0.317 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 4.823742e-01 | 0.317 |
| R-HSA-264876 | Insulin processing | 4.823742e-01 | 0.317 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.823742e-01 | 0.317 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.866901e-01 | 0.313 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.866901e-01 | 0.313 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.900496e-01 | 0.310 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.926116e-01 | 0.307 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 4.926116e-01 | 0.307 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.926116e-01 | 0.307 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.926116e-01 | 0.307 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.926116e-01 | 0.307 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.930389e-01 | 0.307 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.930389e-01 | 0.307 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.950276e-01 | 0.305 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.959922e-01 | 0.305 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 5.026471e-01 | 0.299 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 5.026471e-01 | 0.299 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 5.026471e-01 | 0.299 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.117849e-01 | 0.291 |
| R-HSA-5619084 | ABC transporter disorders | 5.117849e-01 | 0.291 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 5.124847e-01 | 0.290 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 5.124847e-01 | 0.290 |
| R-HSA-112311 | Neurotransmitter clearance | 5.124847e-01 | 0.290 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.146930e-01 | 0.288 |
| R-HSA-168249 | Innate Immune System | 5.218648e-01 | 0.282 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.221283e-01 | 0.282 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 5.221283e-01 | 0.282 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 5.221283e-01 | 0.282 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 5.221283e-01 | 0.282 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.240273e-01 | 0.281 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.300707e-01 | 0.276 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 5.315818e-01 | 0.274 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.315818e-01 | 0.274 |
| R-HSA-397795 | G-protein beta:gamma signalling | 5.408488e-01 | 0.267 |
| R-HSA-9930044 | Nuclear RNA decay | 5.408488e-01 | 0.267 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.408488e-01 | 0.267 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.408488e-01 | 0.267 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.408488e-01 | 0.267 |
| R-HSA-9733709 | Cardiogenesis | 5.408488e-01 | 0.267 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 5.408488e-01 | 0.267 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 5.408488e-01 | 0.267 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.499330e-01 | 0.260 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.499330e-01 | 0.260 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 5.499330e-01 | 0.260 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 5.499330e-01 | 0.260 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.527599e-01 | 0.257 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.537193e-01 | 0.257 |
| R-HSA-9658195 | Leishmania infection | 5.558675e-01 | 0.255 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.558675e-01 | 0.255 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.563273e-01 | 0.255 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.588381e-01 | 0.253 |
| R-HSA-203615 | eNOS activation | 5.588381e-01 | 0.253 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.588381e-01 | 0.253 |
| R-HSA-5673000 | RAF activation | 5.588381e-01 | 0.253 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.588381e-01 | 0.253 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 5.588381e-01 | 0.253 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 5.588381e-01 | 0.253 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.588381e-01 | 0.253 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.590943e-01 | 0.253 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.652249e-01 | 0.248 |
| R-HSA-9909396 | Circadian clock | 5.665730e-01 | 0.247 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.675675e-01 | 0.246 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.675675e-01 | 0.246 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.675675e-01 | 0.246 |
| R-HSA-187687 | Signalling to ERKs | 5.675675e-01 | 0.246 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 5.675675e-01 | 0.246 |
| R-HSA-70268 | Pyruvate metabolism | 5.708975e-01 | 0.243 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.761247e-01 | 0.239 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.761247e-01 | 0.239 |
| R-HSA-8853659 | RET signaling | 5.761247e-01 | 0.239 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.813688e-01 | 0.236 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.845131e-01 | 0.233 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.845131e-01 | 0.233 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 5.845131e-01 | 0.233 |
| R-HSA-196757 | Metabolism of folate and pterines | 5.845131e-01 | 0.233 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 5.845131e-01 | 0.233 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.875925e-01 | 0.231 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.875925e-01 | 0.231 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.927360e-01 | 0.227 |
| R-HSA-8875878 | MET promotes cell motility | 5.927360e-01 | 0.227 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 5.927360e-01 | 0.227 |
| R-HSA-74217 | Purine salvage | 5.927360e-01 | 0.227 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 6.007966e-01 | 0.221 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 6.007966e-01 | 0.221 |
| R-HSA-71336 | Pentose phosphate pathway | 6.007966e-01 | 0.221 |
| R-HSA-9648002 | RAS processing | 6.007966e-01 | 0.221 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.030646e-01 | 0.220 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 6.086982e-01 | 0.216 |
| R-HSA-71240 | Tryptophan catabolism | 6.086982e-01 | 0.216 |
| R-HSA-8982491 | Glycogen metabolism | 6.086982e-01 | 0.216 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 6.086982e-01 | 0.216 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.143394e-01 | 0.212 |
| R-HSA-1474290 | Collagen formation | 6.143394e-01 | 0.212 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.164439e-01 | 0.210 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 6.164439e-01 | 0.210 |
| R-HSA-9694548 | Maturation of spike protein | 6.164439e-01 | 0.210 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.234411e-01 | 0.205 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.240367e-01 | 0.205 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.240367e-01 | 0.205 |
| R-HSA-6811438 | Intra-Golgi traffic | 6.240367e-01 | 0.205 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 6.240367e-01 | 0.205 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.274681e-01 | 0.202 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 6.314796e-01 | 0.200 |
| R-HSA-991365 | Activation of GABAB receptors | 6.314796e-01 | 0.200 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6.314796e-01 | 0.200 |
| R-HSA-977444 | GABA B receptor activation | 6.314796e-01 | 0.200 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 6.314796e-01 | 0.200 |
| R-HSA-1433557 | Signaling by SCF-KIT | 6.387757e-01 | 0.195 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 6.387757e-01 | 0.195 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.387757e-01 | 0.195 |
| R-HSA-166520 | Signaling by NTRKs | 6.437497e-01 | 0.191 |
| R-HSA-69236 | G1 Phase | 6.459278e-01 | 0.190 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.459278e-01 | 0.190 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.495285e-01 | 0.187 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.529386e-01 | 0.185 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 6.529386e-01 | 0.185 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.529386e-01 | 0.185 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 6.529386e-01 | 0.185 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.529386e-01 | 0.185 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.598111e-01 | 0.181 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.598111e-01 | 0.181 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.598111e-01 | 0.181 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.598111e-01 | 0.181 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.598111e-01 | 0.181 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.598111e-01 | 0.181 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.598111e-01 | 0.181 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.598111e-01 | 0.181 |
| R-HSA-9609507 | Protein localization | 6.633891e-01 | 0.178 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.665479e-01 | 0.176 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 6.665479e-01 | 0.176 |
| R-HSA-9833110 | RSV-host interactions | 6.730730e-01 | 0.172 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.731518e-01 | 0.172 |
| R-HSA-389356 | Co-stimulation by CD28 | 6.731518e-01 | 0.172 |
| R-HSA-425410 | Metal ion SLC transporters | 6.731518e-01 | 0.172 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.776253e-01 | 0.169 |
| R-HSA-73893 | DNA Damage Bypass | 6.796252e-01 | 0.168 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.796252e-01 | 0.168 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.796252e-01 | 0.168 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 6.796252e-01 | 0.168 |
| R-HSA-418346 | Platelet homeostasis | 6.821260e-01 | 0.166 |
| R-HSA-9748787 | Azathioprine ADME | 6.859708e-01 | 0.164 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 6.921911e-01 | 0.160 |
| R-HSA-2514856 | The phototransduction cascade | 6.921911e-01 | 0.160 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.982886e-01 | 0.156 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.982886e-01 | 0.156 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.982886e-01 | 0.156 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.982886e-01 | 0.156 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.996177e-01 | 0.155 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.996177e-01 | 0.155 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 7.042656e-01 | 0.152 |
| R-HSA-8951664 | Neddylation | 7.084569e-01 | 0.150 |
| R-HSA-418597 | G alpha (z) signalling events | 7.158679e-01 | 0.145 |
| R-HSA-193648 | NRAGE signals death through JNK | 7.214977e-01 | 0.142 |
| R-HSA-5654736 | Signaling by FGFR1 | 7.214977e-01 | 0.142 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.266502e-01 | 0.139 |
| R-HSA-418555 | G alpha (s) signalling events | 7.307998e-01 | 0.136 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 7.324260e-01 | 0.135 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 7.324260e-01 | 0.135 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.360655e-01 | 0.133 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.372401e-01 | 0.132 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.372401e-01 | 0.132 |
| R-HSA-186712 | Regulation of beta-cell development | 7.377287e-01 | 0.132 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 7.377287e-01 | 0.132 |
| R-HSA-9033241 | Peroxisomal protein import | 7.377287e-01 | 0.132 |
| R-HSA-977443 | GABA receptor activation | 7.429267e-01 | 0.129 |
| R-HSA-156590 | Glutathione conjugation | 7.429267e-01 | 0.129 |
| R-HSA-450294 | MAP kinase activation | 7.480219e-01 | 0.126 |
| R-HSA-1442490 | Collagen degradation | 7.480219e-01 | 0.126 |
| R-HSA-8956321 | Nucleotide salvage | 7.480219e-01 | 0.126 |
| R-HSA-611105 | Respiratory electron transport | 7.528091e-01 | 0.123 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.530165e-01 | 0.123 |
| R-HSA-6799198 | Complex I biogenesis | 7.579124e-01 | 0.120 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.579124e-01 | 0.120 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.627115e-01 | 0.118 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.674158e-01 | 0.115 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 7.720271e-01 | 0.112 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 7.765473e-01 | 0.110 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 7.765473e-01 | 0.110 |
| R-HSA-9830369 | Kidney development | 7.765473e-01 | 0.110 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.787546e-01 | 0.109 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.895787e-01 | 0.103 |
| R-HSA-448424 | Interleukin-17 signaling | 7.895787e-01 | 0.103 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 7.895787e-01 | 0.103 |
| R-HSA-5576891 | Cardiac conduction | 7.915828e-01 | 0.102 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 8.018523e-01 | 0.096 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 8.057828e-01 | 0.094 |
| R-HSA-1236394 | Signaling by ERBB4 | 8.057828e-01 | 0.094 |
| R-HSA-1980143 | Signaling by NOTCH1 | 8.134122e-01 | 0.090 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 8.171140e-01 | 0.088 |
| R-HSA-9694635 | Translation of Structural Proteins | 8.171140e-01 | 0.088 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.198227e-01 | 0.086 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.293067e-01 | 0.081 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.378372e-01 | 0.077 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.410559e-01 | 0.075 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 8.410559e-01 | 0.075 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 8.442109e-01 | 0.074 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.473035e-01 | 0.072 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.487037e-01 | 0.071 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.503348e-01 | 0.070 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 8.503348e-01 | 0.070 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.533287e-01 | 0.069 |
| R-HSA-1989781 | PPARA activates gene expression | 8.600255e-01 | 0.065 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.643337e-01 | 0.063 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.699391e-01 | 0.061 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.699391e-01 | 0.061 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.705691e-01 | 0.060 |
| R-HSA-2029481 | FCGR activation | 8.725224e-01 | 0.059 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.725224e-01 | 0.059 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.759321e-01 | 0.058 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.817906e-01 | 0.055 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.846913e-01 | 0.053 |
| R-HSA-15869 | Metabolism of nucleotides | 8.857295e-01 | 0.053 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.869824e-01 | 0.052 |
| R-HSA-422356 | Regulation of insulin secretion | 8.869824e-01 | 0.052 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.892282e-01 | 0.051 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.892282e-01 | 0.051 |
| R-HSA-1483255 | PI Metabolism | 8.957019e-01 | 0.048 |
| R-HSA-111885 | Opioid Signalling | 8.998068e-01 | 0.046 |
| R-HSA-5696398 | Nucleotide Excision Repair | 9.037506e-01 | 0.044 |
| R-HSA-2672351 | Stimuli-sensing channels | 9.093780e-01 | 0.041 |
| R-HSA-8957322 | Metabolism of steroids | 9.128246e-01 | 0.040 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 9.129462e-01 | 0.040 |
| R-HSA-1474244 | Extracellular matrix organization | 9.203529e-01 | 0.036 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 9.212657e-01 | 0.036 |
| R-HSA-9007101 | Rab regulation of trafficking | 9.273467e-01 | 0.033 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.329594e-01 | 0.030 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.405783e-01 | 0.027 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 9.473338e-01 | 0.023 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 9.483827e-01 | 0.023 |
| R-HSA-2187338 | Visual phototransduction | 9.633413e-01 | 0.016 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.645226e-01 | 0.016 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.654909e-01 | 0.015 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.700305e-01 | 0.013 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.772487e-01 | 0.010 |
| R-HSA-3781865 | Diseases of glycosylation | 9.829629e-01 | 0.007 |
| R-HSA-983712 | Ion channel transport | 9.845990e-01 | 0.007 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.857943e-01 | 0.006 |
| R-HSA-1483257 | Phospholipid metabolism | 9.869556e-01 | 0.006 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.883933e-01 | 0.005 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.900803e-01 | 0.004 |
| R-HSA-9748784 | Drug ADME | 9.916018e-01 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 9.939100e-01 | 0.003 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.945105e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.958844e-01 | 0.002 |
| R-HSA-416476 | G alpha (q) signalling events | 9.966934e-01 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 9.982852e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.982852e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.999194e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999436e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999797e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.999811e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.999838e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999993e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.901 | -0.043 | 1 | 0.851 |
TTK |
0.901 | 0.174 | -2 | 0.904 |
PKR |
0.900 | 0.106 | 1 | 0.887 |
TAK1 |
0.899 | -0.013 | 1 | 0.869 |
EEF2K |
0.897 | 0.114 | 3 | 0.832 |
VRK2 |
0.896 | -0.226 | 1 | 0.920 |
TNIK |
0.895 | 0.078 | 3 | 0.851 |
VRK1 |
0.895 | -0.125 | 2 | 0.863 |
MINK |
0.895 | 0.022 | 1 | 0.834 |
MST2 |
0.893 | 0.040 | 1 | 0.862 |
MEKK2 |
0.893 | 0.033 | 2 | 0.855 |
NEK1 |
0.893 | -0.027 | 1 | 0.846 |
MST1 |
0.892 | 0.022 | 1 | 0.843 |
TAO2 |
0.892 | 0.011 | 2 | 0.912 |
LRRK2 |
0.891 | -0.135 | 2 | 0.897 |
ASK1 |
0.891 | -0.127 | 1 | 0.808 |
BRAF |
0.891 | -0.038 | -4 | 0.842 |
GCK |
0.890 | -0.006 | 1 | 0.837 |
BMPR2 |
0.890 | -0.012 | -2 | 0.949 |
HGK |
0.890 | 0.028 | 3 | 0.848 |
NEK5 |
0.888 | -0.022 | 1 | 0.868 |
NIK |
0.888 | 0.002 | -3 | 0.884 |
MYO3A |
0.888 | 0.039 | 1 | 0.835 |
MAP3K15 |
0.887 | -0.060 | 1 | 0.816 |
MYO3B |
0.887 | 0.049 | 2 | 0.887 |
MEK1 |
0.887 | -0.177 | 2 | 0.859 |
MEK5 |
0.887 | -0.199 | 2 | 0.864 |
MEKK1 |
0.886 | 0.001 | 1 | 0.873 |
KHS1 |
0.886 | 0.018 | 1 | 0.821 |
ALK4 |
0.886 | 0.065 | -2 | 0.895 |
MST3 |
0.886 | 0.112 | 2 | 0.904 |
YSK1 |
0.885 | 0.044 | 2 | 0.877 |
ALPHAK3 |
0.885 | -0.007 | -1 | 0.803 |
MEKK6 |
0.885 | -0.050 | 1 | 0.843 |
NEK8 |
0.885 | -0.019 | 2 | 0.883 |
ANKRD3 |
0.884 | 0.009 | 1 | 0.898 |
CAMKK1 |
0.884 | -0.105 | -2 | 0.834 |
KHS2 |
0.884 | 0.056 | 1 | 0.828 |
OSR1 |
0.884 | -0.022 | 2 | 0.837 |
NEK4 |
0.883 | -0.044 | 1 | 0.838 |
DAPK2 |
0.883 | -0.045 | -3 | 0.862 |
TAO3 |
0.883 | 0.003 | 1 | 0.844 |
CAMKK2 |
0.882 | -0.124 | -2 | 0.822 |
MOS |
0.881 | 0.140 | 1 | 0.932 |
LKB1 |
0.881 | -0.118 | -3 | 0.860 |
HPK1 |
0.881 | -0.021 | 1 | 0.820 |
PRPK |
0.881 | -0.076 | -1 | 0.882 |
ALK2 |
0.880 | 0.115 | -2 | 0.883 |
CAMLCK |
0.880 | -0.034 | -2 | 0.882 |
PDK1 |
0.880 | -0.185 | 1 | 0.819 |
MEKK3 |
0.879 | -0.062 | 1 | 0.854 |
STLK3 |
0.878 | -0.184 | 1 | 0.820 |
BIKE |
0.878 | -0.050 | 1 | 0.704 |
YSK4 |
0.878 | -0.014 | 1 | 0.825 |
ZAK |
0.878 | -0.029 | 1 | 0.844 |
MEK2 |
0.877 | -0.248 | 2 | 0.826 |
NEK11 |
0.877 | -0.150 | 1 | 0.832 |
DLK |
0.877 | -0.188 | 1 | 0.892 |
NLK |
0.876 | 0.062 | 1 | 0.848 |
TGFBR1 |
0.876 | 0.115 | -2 | 0.870 |
BMPR1B |
0.874 | 0.199 | 1 | 0.853 |
PERK |
0.873 | -0.006 | -2 | 0.914 |
CAMK1B |
0.873 | -0.052 | -3 | 0.854 |
ATR |
0.873 | 0.020 | 1 | 0.893 |
LATS1 |
0.872 | 0.033 | -3 | 0.840 |
SMMLCK |
0.872 | -0.032 | -3 | 0.806 |
HRI |
0.872 | -0.029 | -2 | 0.924 |
ACVR2B |
0.872 | 0.109 | -2 | 0.886 |
ACVR2A |
0.872 | 0.110 | -2 | 0.876 |
DMPK1 |
0.871 | 0.047 | -3 | 0.724 |
LOK |
0.871 | -0.028 | -2 | 0.821 |
CDKL1 |
0.870 | 0.003 | -3 | 0.790 |
MPSK1 |
0.870 | -0.059 | 1 | 0.790 |
MLK1 |
0.869 | 0.080 | 2 | 0.891 |
MLK2 |
0.869 | -0.079 | 2 | 0.873 |
PBK |
0.869 | -0.096 | 1 | 0.759 |
DAPK3 |
0.868 | -0.012 | -3 | 0.770 |
RAF1 |
0.868 | -0.053 | 1 | 0.893 |
PRP4 |
0.868 | 0.054 | -3 | 0.822 |
NEK9 |
0.867 | -0.033 | 2 | 0.888 |
TAO1 |
0.866 | -0.043 | 1 | 0.776 |
ROCK2 |
0.866 | 0.027 | -3 | 0.757 |
DSTYK |
0.865 | 0.178 | 2 | 0.942 |
PLK1 |
0.865 | 0.003 | -2 | 0.898 |
COT |
0.865 | 0.202 | 2 | 0.908 |
PASK |
0.864 | -0.106 | -3 | 0.832 |
BMPR1A |
0.864 | 0.163 | 1 | 0.842 |
TLK1 |
0.863 | -0.026 | -2 | 0.903 |
WNK4 |
0.863 | -0.069 | -2 | 0.895 |
IRAK4 |
0.862 | -0.023 | 1 | 0.842 |
NEK2 |
0.862 | -0.009 | 2 | 0.871 |
AAK1 |
0.862 | -0.019 | 1 | 0.581 |
ICK |
0.862 | -0.059 | -3 | 0.822 |
P38A |
0.861 | -0.001 | 1 | 0.689 |
SKMLCK |
0.861 | -0.012 | -2 | 0.879 |
JNK3 |
0.861 | -0.003 | 1 | 0.649 |
MLK3 |
0.861 | 0.142 | 2 | 0.843 |
JNK2 |
0.861 | 0.018 | 1 | 0.608 |
TLK2 |
0.860 | -0.059 | 1 | 0.864 |
NEK3 |
0.860 | -0.094 | 1 | 0.805 |
PKCD |
0.860 | 0.138 | 2 | 0.873 |
WNK1 |
0.859 | 0.044 | -2 | 0.901 |
GRK6 |
0.859 | -0.008 | 1 | 0.907 |
CAMK2G |
0.859 | -0.069 | 2 | 0.854 |
MLK4 |
0.858 | 0.058 | 2 | 0.808 |
ERK5 |
0.858 | -0.007 | 1 | 0.799 |
PKN3 |
0.857 | 0.005 | -3 | 0.825 |
TSSK2 |
0.857 | -0.003 | -5 | 0.841 |
PDHK4 |
0.857 | -0.317 | 1 | 0.900 |
PDHK1 |
0.857 | -0.200 | 1 | 0.894 |
GRK5 |
0.857 | -0.131 | -3 | 0.885 |
RIPK3 |
0.856 | -0.014 | 3 | 0.790 |
P38B |
0.855 | 0.001 | 1 | 0.620 |
MST4 |
0.855 | 0.130 | 2 | 0.908 |
GRK7 |
0.855 | 0.082 | 1 | 0.826 |
SLK |
0.855 | -0.097 | -2 | 0.775 |
TGFBR2 |
0.855 | 0.095 | -2 | 0.877 |
MASTL |
0.854 | -0.350 | -2 | 0.873 |
AMPKA1 |
0.854 | 0.024 | -3 | 0.832 |
RIPK1 |
0.854 | -0.219 | 1 | 0.856 |
MARK4 |
0.853 | 0.100 | 4 | 0.912 |
ROCK1 |
0.853 | 0.015 | -3 | 0.724 |
CHAK2 |
0.852 | -0.102 | -1 | 0.829 |
HASPIN |
0.852 | -0.016 | -1 | 0.683 |
NEK7 |
0.852 | -0.003 | -3 | 0.863 |
IRE2 |
0.852 | 0.075 | 2 | 0.815 |
DAPK1 |
0.852 | -0.059 | -3 | 0.751 |
CDC7 |
0.852 | 0.055 | 1 | 0.916 |
ULK2 |
0.851 | -0.034 | 2 | 0.828 |
PINK1 |
0.851 | -0.174 | 1 | 0.840 |
NUAK2 |
0.851 | 0.030 | -3 | 0.814 |
HUNK |
0.851 | -0.091 | 2 | 0.825 |
ERK2 |
0.850 | -0.030 | 1 | 0.662 |
PLK3 |
0.850 | -0.032 | 2 | 0.798 |
PKN2 |
0.850 | 0.027 | -3 | 0.827 |
PIM3 |
0.850 | 0.020 | -3 | 0.815 |
ERK7 |
0.849 | 0.110 | 2 | 0.648 |
ATM |
0.849 | 0.068 | 1 | 0.841 |
WNK3 |
0.849 | -0.131 | 1 | 0.863 |
NEK6 |
0.848 | 0.091 | -2 | 0.932 |
CHAK1 |
0.848 | -0.099 | 2 | 0.812 |
CDKL5 |
0.848 | 0.021 | -3 | 0.776 |
DNAPK |
0.848 | 0.047 | 1 | 0.750 |
PIM1 |
0.848 | 0.025 | -3 | 0.747 |
PIM2 |
0.848 | 0.023 | -3 | 0.715 |
CLK3 |
0.847 | 0.147 | 1 | 0.860 |
TSSK1 |
0.846 | 0.007 | -3 | 0.851 |
TBK1 |
0.846 | -0.061 | 1 | 0.787 |
IRE1 |
0.846 | -0.012 | 1 | 0.831 |
IRAK1 |
0.846 | -0.219 | -1 | 0.761 |
CDK5 |
0.846 | 0.042 | 1 | 0.687 |
HIPK1 |
0.846 | 0.021 | 1 | 0.722 |
P38G |
0.845 | 0.008 | 1 | 0.531 |
DRAK1 |
0.845 | -0.101 | 1 | 0.788 |
MTOR |
0.845 | -0.113 | 1 | 0.813 |
MRCKA |
0.845 | -0.012 | -3 | 0.725 |
MRCKB |
0.845 | -0.000 | -3 | 0.709 |
PKCA |
0.844 | 0.121 | 2 | 0.829 |
P70S6KB |
0.844 | -0.028 | -3 | 0.774 |
CHK1 |
0.844 | -0.123 | -3 | 0.809 |
BUB1 |
0.843 | -0.016 | -5 | 0.793 |
SMG1 |
0.843 | -0.031 | 1 | 0.843 |
GRK2 |
0.843 | -0.072 | -2 | 0.781 |
TTBK2 |
0.842 | -0.115 | 2 | 0.746 |
PKCH |
0.842 | 0.051 | 2 | 0.820 |
DCAMKL1 |
0.842 | -0.120 | -3 | 0.751 |
MARK2 |
0.841 | 0.108 | 4 | 0.846 |
QIK |
0.840 | 0.000 | -3 | 0.820 |
AMPKA2 |
0.839 | -0.009 | -3 | 0.793 |
MYLK4 |
0.839 | -0.042 | -2 | 0.790 |
P38D |
0.839 | 0.011 | 1 | 0.546 |
SGK3 |
0.839 | -0.003 | -3 | 0.736 |
ERK1 |
0.839 | -0.010 | 1 | 0.602 |
CDK2 |
0.839 | 0.029 | 1 | 0.722 |
PKCB |
0.839 | 0.111 | 2 | 0.841 |
PKCZ |
0.839 | -0.008 | 2 | 0.853 |
IKKE |
0.838 | -0.095 | 1 | 0.785 |
HIPK3 |
0.838 | -0.026 | 1 | 0.720 |
RIPK2 |
0.838 | -0.246 | 1 | 0.797 |
CDK1 |
0.838 | 0.029 | 1 | 0.626 |
MOK |
0.838 | 0.025 | 1 | 0.730 |
CAMK2D |
0.838 | -0.094 | -3 | 0.829 |
DYRK2 |
0.837 | -0.011 | 1 | 0.707 |
CRIK |
0.836 | -0.047 | -3 | 0.661 |
CDK14 |
0.836 | 0.010 | 1 | 0.638 |
DCAMKL2 |
0.836 | -0.156 | -3 | 0.778 |
PKCG |
0.835 | 0.091 | 2 | 0.838 |
MARK1 |
0.835 | 0.049 | 4 | 0.890 |
PAK2 |
0.835 | -0.111 | -2 | 0.789 |
MELK |
0.835 | -0.079 | -3 | 0.780 |
GRK1 |
0.834 | 0.040 | -2 | 0.851 |
CDK6 |
0.834 | -0.003 | 1 | 0.610 |
JNK1 |
0.834 | -0.048 | 1 | 0.599 |
RSK2 |
0.833 | 0.027 | -3 | 0.741 |
PLK2 |
0.833 | -0.024 | -3 | 0.837 |
SRPK3 |
0.833 | 0.004 | -3 | 0.707 |
NIM1 |
0.833 | -0.057 | 3 | 0.803 |
QSK |
0.833 | 0.064 | 4 | 0.904 |
ULK1 |
0.833 | -0.128 | -3 | 0.862 |
MARK3 |
0.832 | 0.100 | 4 | 0.881 |
SSTK |
0.832 | 0.003 | 4 | 0.892 |
NDR1 |
0.832 | -0.013 | -3 | 0.815 |
AKT2 |
0.832 | -0.012 | -3 | 0.648 |
MAK |
0.832 | 0.003 | -2 | 0.732 |
GCN2 |
0.832 | -0.078 | 2 | 0.844 |
CLK4 |
0.832 | -0.009 | -3 | 0.736 |
GRK4 |
0.832 | -0.127 | -2 | 0.895 |
IKKB |
0.831 | -0.106 | -2 | 0.826 |
CDK16 |
0.831 | 0.072 | 1 | 0.559 |
DYRK1A |
0.831 | -0.055 | 1 | 0.744 |
P90RSK |
0.831 | -0.029 | -3 | 0.751 |
HIPK4 |
0.831 | -0.017 | 1 | 0.811 |
CAMK4 |
0.831 | -0.172 | -3 | 0.797 |
PKCE |
0.831 | 0.082 | 2 | 0.826 |
PKCT |
0.830 | 0.037 | 2 | 0.822 |
GSK3B |
0.830 | -0.105 | 4 | 0.389 |
CHK2 |
0.830 | -0.071 | -3 | 0.590 |
PKCI |
0.830 | 0.021 | 2 | 0.831 |
PAK1 |
0.829 | -0.083 | -2 | 0.798 |
CDK4 |
0.829 | -0.034 | 1 | 0.600 |
PLK4 |
0.828 | -0.111 | 2 | 0.641 |
CAMK2B |
0.828 | -0.021 | 2 | 0.816 |
PAK3 |
0.827 | -0.109 | -2 | 0.800 |
AKT1 |
0.827 | 0.007 | -3 | 0.664 |
MAPKAPK3 |
0.827 | -0.077 | -3 | 0.747 |
CAMK1D |
0.827 | -0.076 | -3 | 0.642 |
GSK3A |
0.827 | -0.057 | 4 | 0.397 |
AURB |
0.826 | -0.003 | -2 | 0.665 |
SRPK1 |
0.826 | 0.015 | -3 | 0.726 |
CAMK1G |
0.826 | -0.078 | -3 | 0.738 |
CDK17 |
0.826 | -0.005 | 1 | 0.538 |
STK33 |
0.825 | -0.207 | 2 | 0.651 |
PDHK3_TYR |
0.825 | 0.099 | 4 | 0.877 |
CDK3 |
0.825 | 0.069 | 1 | 0.556 |
DYRK3 |
0.825 | -0.017 | 1 | 0.731 |
BCKDK |
0.824 | -0.150 | -1 | 0.810 |
DYRK1B |
0.824 | -0.029 | 1 | 0.652 |
SGK1 |
0.824 | -0.022 | -3 | 0.564 |
CDK8 |
0.823 | -0.041 | 1 | 0.668 |
CDK18 |
0.823 | 0.017 | 1 | 0.590 |
PRKD3 |
0.823 | -0.069 | -3 | 0.714 |
SIK |
0.823 | 0.030 | -3 | 0.733 |
NUAK1 |
0.822 | -0.026 | -3 | 0.766 |
CLK1 |
0.822 | 0.017 | -3 | 0.712 |
IKKA |
0.822 | -0.064 | -2 | 0.817 |
RSK3 |
0.822 | -0.021 | -3 | 0.747 |
CAMK2A |
0.820 | -0.053 | 2 | 0.844 |
TTBK1 |
0.820 | -0.135 | 2 | 0.665 |
PKACG |
0.820 | -0.044 | -2 | 0.761 |
CDK13 |
0.820 | -0.072 | 1 | 0.639 |
CDK7 |
0.820 | -0.059 | 1 | 0.669 |
LATS2 |
0.820 | -0.006 | -5 | 0.847 |
PKG2 |
0.819 | -0.008 | -2 | 0.685 |
TESK1_TYR |
0.819 | -0.038 | 3 | 0.878 |
MNK1 |
0.819 | -0.036 | -2 | 0.821 |
PHKG1 |
0.818 | -0.040 | -3 | 0.800 |
RSK4 |
0.818 | 0.008 | -3 | 0.703 |
MNK2 |
0.818 | -0.042 | -2 | 0.810 |
EPHA6 |
0.818 | 0.131 | -1 | 0.883 |
PKMYT1_TYR |
0.817 | -0.055 | 3 | 0.861 |
MAP2K7_TYR |
0.816 | -0.178 | 2 | 0.893 |
CDK12 |
0.816 | -0.069 | 1 | 0.611 |
MSK1 |
0.816 | -0.058 | -3 | 0.723 |
PDHK4_TYR |
0.816 | -0.016 | 2 | 0.906 |
NDR2 |
0.816 | -0.009 | -3 | 0.819 |
MSK2 |
0.816 | -0.098 | -3 | 0.713 |
MAP2K4_TYR |
0.816 | -0.143 | -1 | 0.898 |
CDK10 |
0.815 | 0.022 | 1 | 0.619 |
CAMK1A |
0.815 | -0.060 | -3 | 0.615 |
AURA |
0.815 | -0.036 | -2 | 0.636 |
BMPR2_TYR |
0.815 | -0.036 | -1 | 0.873 |
MAP2K6_TYR |
0.815 | -0.089 | -1 | 0.894 |
PRKD1 |
0.814 | -0.100 | -3 | 0.803 |
PINK1_TYR |
0.814 | -0.117 | 1 | 0.885 |
CK2A2 |
0.814 | 0.154 | 1 | 0.772 |
PDHK1_TYR |
0.814 | -0.058 | -1 | 0.908 |
P70S6K |
0.814 | -0.079 | -3 | 0.683 |
GRK3 |
0.814 | -0.068 | -2 | 0.736 |
HIPK2 |
0.813 | -0.006 | 1 | 0.607 |
CDK9 |
0.813 | -0.098 | 1 | 0.643 |
DYRK4 |
0.812 | -0.023 | 1 | 0.620 |
SNRK |
0.812 | -0.216 | 2 | 0.715 |
EPHB4 |
0.812 | 0.061 | -1 | 0.879 |
TXK |
0.812 | 0.187 | 1 | 0.894 |
TYK2 |
0.811 | -0.055 | 1 | 0.863 |
RET |
0.811 | -0.051 | 1 | 0.863 |
FAM20C |
0.811 | 0.124 | 2 | 0.650 |
LIMK2_TYR |
0.811 | -0.038 | -3 | 0.900 |
ROS1 |
0.811 | -0.005 | 3 | 0.805 |
TYRO3 |
0.810 | -0.035 | 3 | 0.824 |
MST1R |
0.810 | -0.050 | 3 | 0.836 |
CSF1R |
0.810 | 0.005 | 3 | 0.829 |
PKN1 |
0.810 | -0.037 | -3 | 0.693 |
SRPK2 |
0.809 | 0.019 | -3 | 0.645 |
YES1 |
0.809 | 0.051 | -1 | 0.881 |
CK1D |
0.809 | -0.063 | -3 | 0.472 |
PRKD2 |
0.809 | -0.049 | -3 | 0.732 |
LIMK1_TYR |
0.808 | -0.141 | 2 | 0.894 |
AURC |
0.808 | 0.006 | -2 | 0.664 |
BRSK2 |
0.808 | -0.075 | -3 | 0.796 |
SBK |
0.808 | -0.073 | -3 | 0.520 |
ABL2 |
0.808 | 0.045 | -1 | 0.860 |
BLK |
0.807 | 0.165 | -1 | 0.867 |
JAK2 |
0.807 | -0.081 | 1 | 0.857 |
CDK19 |
0.807 | -0.046 | 1 | 0.622 |
LCK |
0.807 | 0.109 | -1 | 0.849 |
PKACB |
0.807 | -0.003 | -2 | 0.686 |
MAPKAPK2 |
0.806 | -0.044 | -3 | 0.692 |
FGR |
0.806 | -0.016 | 1 | 0.885 |
PHKG2 |
0.806 | -0.028 | -3 | 0.776 |
TNNI3K_TYR |
0.806 | 0.120 | 1 | 0.877 |
BRSK1 |
0.805 | -0.053 | -3 | 0.770 |
HCK |
0.805 | 0.026 | -1 | 0.852 |
SRMS |
0.805 | 0.036 | 1 | 0.922 |
TEC |
0.804 | 0.102 | -1 | 0.800 |
JAK3 |
0.804 | -0.061 | 1 | 0.839 |
FER |
0.804 | -0.069 | 1 | 0.928 |
CK2A1 |
0.804 | 0.107 | 1 | 0.749 |
ITK |
0.803 | 0.029 | -1 | 0.827 |
AKT3 |
0.803 | -0.000 | -3 | 0.577 |
ABL1 |
0.803 | 0.011 | -1 | 0.855 |
INSRR |
0.803 | -0.045 | 3 | 0.786 |
EPHB1 |
0.803 | 0.010 | 1 | 0.918 |
TNK2 |
0.802 | 0.006 | 3 | 0.804 |
KDR |
0.802 | 0.005 | 3 | 0.806 |
DDR1 |
0.802 | -0.163 | 4 | 0.823 |
PDGFRB |
0.802 | -0.062 | 3 | 0.837 |
EPHA4 |
0.802 | -0.011 | 2 | 0.794 |
EPHB3 |
0.802 | 0.010 | -1 | 0.869 |
KIT |
0.802 | -0.048 | 3 | 0.829 |
CLK2 |
0.802 | 0.041 | -3 | 0.718 |
EPHB2 |
0.801 | 0.038 | -1 | 0.862 |
JAK1 |
0.801 | 0.041 | 1 | 0.798 |
MAPKAPK5 |
0.801 | -0.197 | -3 | 0.704 |
FLT3 |
0.801 | -0.062 | 3 | 0.820 |
CK1A2 |
0.801 | -0.080 | -3 | 0.466 |
PAK6 |
0.801 | -0.022 | -2 | 0.723 |
TEK |
0.799 | -0.073 | 3 | 0.775 |
FGFR2 |
0.799 | -0.098 | 3 | 0.823 |
CK1E |
0.798 | -0.067 | -3 | 0.523 |
FGFR1 |
0.797 | -0.090 | 3 | 0.810 |
BMX |
0.797 | 0.008 | -1 | 0.765 |
AXL |
0.797 | -0.054 | 3 | 0.816 |
MET |
0.797 | -0.046 | 3 | 0.814 |
FRK |
0.797 | 0.038 | -1 | 0.879 |
ALK |
0.796 | -0.045 | 3 | 0.764 |
EPHA7 |
0.796 | 0.019 | 2 | 0.802 |
BTK |
0.796 | -0.088 | -1 | 0.796 |
YANK3 |
0.796 | -0.143 | 2 | 0.425 |
PKACA |
0.795 | -0.035 | -2 | 0.629 |
MERTK |
0.795 | -0.044 | 3 | 0.809 |
FYN |
0.795 | 0.053 | -1 | 0.825 |
PDGFRA |
0.795 | -0.148 | 3 | 0.837 |
KIS |
0.794 | 0.025 | 1 | 0.696 |
LTK |
0.794 | -0.054 | 3 | 0.786 |
LYN |
0.794 | 0.014 | 3 | 0.760 |
FLT1 |
0.793 | -0.050 | -1 | 0.847 |
TNK1 |
0.792 | -0.121 | 3 | 0.802 |
WEE1_TYR |
0.792 | -0.057 | -1 | 0.771 |
EPHA1 |
0.792 | -0.027 | 3 | 0.799 |
ERBB2 |
0.791 | -0.120 | 1 | 0.827 |
EPHA3 |
0.790 | -0.101 | 2 | 0.772 |
NEK10_TYR |
0.790 | -0.166 | 1 | 0.713 |
FLT4 |
0.790 | -0.117 | 3 | 0.796 |
YANK2 |
0.789 | -0.155 | 2 | 0.446 |
PTK2B |
0.789 | 0.017 | -1 | 0.833 |
NTRK1 |
0.789 | -0.181 | -1 | 0.848 |
NTRK2 |
0.789 | -0.141 | 3 | 0.798 |
PTK6 |
0.788 | -0.177 | -1 | 0.774 |
FGFR3 |
0.788 | -0.123 | 3 | 0.804 |
EPHA5 |
0.787 | -0.009 | 2 | 0.783 |
EPHA8 |
0.787 | -0.015 | -1 | 0.849 |
INSR |
0.786 | -0.152 | 3 | 0.761 |
SRC |
0.786 | -0.021 | -1 | 0.843 |
MATK |
0.785 | -0.086 | -1 | 0.792 |
PAK5 |
0.785 | -0.089 | -2 | 0.661 |
NTRK3 |
0.784 | -0.122 | -1 | 0.809 |
DDR2 |
0.783 | -0.045 | 3 | 0.783 |
EGFR |
0.783 | -0.044 | 1 | 0.748 |
PRKX |
0.781 | 0.008 | -3 | 0.624 |
FGFR4 |
0.778 | -0.087 | -1 | 0.815 |
CSK |
0.776 | -0.165 | 2 | 0.803 |
PTK2 |
0.776 | -0.026 | -1 | 0.769 |
EPHA2 |
0.776 | -0.043 | -1 | 0.801 |
SYK |
0.776 | -0.003 | -1 | 0.784 |
PKG1 |
0.776 | -0.066 | -2 | 0.600 |
MUSK |
0.775 | -0.095 | 1 | 0.728 |
PAK4 |
0.773 | -0.084 | -2 | 0.662 |
CK1G1 |
0.770 | -0.098 | -3 | 0.539 |
ERBB4 |
0.770 | -0.051 | 1 | 0.773 |
IGF1R |
0.769 | -0.180 | 3 | 0.703 |
FES |
0.760 | -0.126 | -1 | 0.749 |
CK1G3 |
0.758 | -0.110 | -3 | 0.334 |
ZAP70 |
0.748 | -0.082 | -1 | 0.706 |
CK1G2 |
0.733 | -0.126 | -3 | 0.443 |
CK1A |
0.729 | -0.122 | -3 | 0.381 |