Motif 777 (n=180)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0B4J203 None S776 ochoa receptor protein-tyrosine kinase (EC 2.7.10.1) None
A6NKT7 RGPD3 T1178 ochoa RanBP2-like and GRIP domain-containing protein 3 None
A6NKT7 RGPD3 S1232 ochoa RanBP2-like and GRIP domain-containing protein 3 None
K7ELQ4 ATF7-NPFF S97 ochoa ATF7-NPFF readthrough None
O00257 CBX4 S442 ochoa E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}.
O00268 TAF4 S648 ochoa Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}.
O14490 DLGAP1 S366 ochoa Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) Part of the postsynaptic scaffold in neuronal cells.
O14646 CHD1 S90 ochoa Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.
O14686 KMT2D S4849 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14715 RGPD8 T1177 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O14715 RGPD8 S1231 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O14795 UNC13B S367 ochoa Protein unc-13 homolog B (Munc13-2) (munc13) Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}.
O15403 SLC16A6 S247 ochoa Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations. {ECO:0000250|UniProtKB:Q7TMR7}.
O43294 TGFB1I1 S143 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O60437 PPL S931 ochoa Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}.
O60641 SNAP91 S306 ochoa Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20) Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}.
O60784 TOM1 S462 ochoa Target of Myb1 membrane trafficking protein (Target of Myb protein 1) Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}.
O75362 ZNF217 S253 ochoa Zinc finger protein 217 Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.
O94956 SLCO2B1 S320 ochoa Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9) Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:26383540, PubMed:27576593, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, PubMed:29871943, Ref.25). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:14610227, ECO:0000269|PubMed:16908597, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20507927, ECO:0000269|PubMed:22201122, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:27576593, ECO:0000269|PubMed:29871943, ECO:0000269|PubMed:34628357, ECO:0000269|PubMed:35714613, ECO:0000269|Ref.25, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 3]: Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1. {ECO:0000269|PubMed:23531488}.
O95235 KIF20A S240 ochoa|psp Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95613 PCNT S2352 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
O95714 HERC2 S1588 ochoa E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}.
O95886 DLGAP3 S416 ochoa Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3) May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
P08603 CFH S219 ochoa Complement factor H (H factor 1) Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:21317894, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed:19503104, PubMed:21317894, PubMed:26700768). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed:18252712, PubMed:23332154, PubMed:28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed:20008295, PubMed:9558116). {ECO:0000269|PubMed:18252712, ECO:0000269|PubMed:19503104, ECO:0000269|PubMed:20008295, ECO:0000269|PubMed:21285368, ECO:0000269|PubMed:21317894, ECO:0000269|PubMed:23332154, ECO:0000269|PubMed:25402769, ECO:0000269|PubMed:26700768, ECO:0000269|PubMed:28671664, ECO:0000269|PubMed:9558116}.; FUNCTION: (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination. {ECO:0000269|PubMed:23332154}.
P08670 VIM S419 ochoa|psp Vimentin Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}.
P0DJD0 RGPD1 T1162 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD0 RGPD1 S1216 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 T1170 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P0DJD1 RGPD2 S1224 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P10721 KIT S943 ochoa Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}.
P11137 MAP2 S788 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P11142 HSPA8 S541 ochoa Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}.
P12270 TPR S1459 ochoa Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P16234 PDGFRA S1016 ochoa Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}.
P17677 GAP43 S151 ochoa Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
P18031 PTPN1 S352 ochoa|psp Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
P18206 VCL S795 ochoa Vinculin (Metavinculin) (MV) Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
P25490 YY1 S247 ochoa|psp Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}.
P26232 CTNNA2 S262 ochoa Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}.
P30101 PDIA3 S163 ochoa Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.
P31943 HNRNPH1 S104 ochoa|psp Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
P33981 TTK S281 ochoa|psp Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P35367 HRH1 S255 ochoa Histamine H1 receptor (H1-R) (H1R) (HH1R) G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}.
P35612 ADD2 S592 ochoa|psp Beta-adducin (Erythrocyte adducin subunit beta) Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.
P42694 HELZ S1317 ochoa Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
P46063 RECQL S64 ochoa ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1) DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977). {ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:19151156, ECO:0000269|PubMed:25831490, ECO:0000269|PubMed:35025765, ECO:0000269|PubMed:7527136, ECO:0000269|PubMed:7961977, ECO:0000269|PubMed:8056767}.
P46100 ATRX S316 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46100 ATRX S598 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46821 MAP1B S1208 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P48681 NES S564 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P49321 NASP S189 ochoa Nuclear autoantigenic sperm protein (NASP) Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.
P49792 RANBP2 T2153 ochoa|psp E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2207 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P52597 HNRNPF S104 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P53004 BLVRA S211 ochoa Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}.
P53367 ARFIP1 S24 ochoa Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.
P55795 HNRNPH2 S104 ochoa|psp Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
P56645 PER3 S923 ochoa Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}.
P61086 UBE2K S159 ochoa Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase) Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:17873885, ECO:0000269|PubMed:19906396, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:8702625}.
P61956 SUMO2 S28 ochoa Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:9556629}.
P78347 GTF2I S210 ochoa General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
P78524 DENND2B S465 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
Q01167 FOXK2 S262 ochoa Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}.
Q02880 TOP2B S1413 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q02952 AKAP12 S283 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q07866 KLC1 S162 ochoa Kinesin light chain 1 (KLC 1) Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}.
Q12923 PTPN13 S273 ochoa Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.
Q13029 PRDM2 S1118 ochoa PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}.
Q13586 STIM1 S668 ochoa|psp Stromal interaction molecule 1 Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}.
Q13610 PWP1 S57 ochoa Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}.
Q14571 ITPR2 S1014 ochoa Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}.
Q14789 GOLGB1 S1936 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q14839 CHD4 S1245 ochoa Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}.
Q15046 KARS1 S49 psp Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}.
Q15291 RBBP5 S497 ochoa Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:Q8BX09, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
Q16643 DBN1 S312 ochoa Drebrin (Developmentally-regulated brain protein) Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.
Q2TBE0 CWF19L2 Y201 ochoa CWF19-like protein 2 None
Q53RE8 ANKRD39 S153 ochoa Ankyrin repeat domain-containing protein 39 None
Q5FWF5 ESCO1 S200 ochoa N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}.
Q5JSZ5 PRRC2B S980 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5SW79 CEP170 S930 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5TAP6 UTP14C S301 ochoa U3 small nucleolar RNA-associated protein 14 homolog C Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}.
Q5TCZ1 SH3PXD2A S547 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5THK1 PRR14L S1485 ochoa Protein PRR14L (Proline rich 14-like protein) None
Q5VT25 CDC42BPA S674 ochoa Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Q5VWN6 TASOR2 S340 ochoa Protein TASOR 2 None
Q6IC98 GRAMD4 S24 ochoa GRAM domain-containing protein 4 (Death-inducing protein) Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity). {ECO:0000250|UniProtKB:Q8CB44, ECO:0000269|PubMed:15565177}.
Q6KC79 NIPBL S588 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6NYC1 JMJD6 S38 ochoa Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}.
Q6PKG0 LARP1 S220 ochoa La-related protein 1 (La ribonucleoprotein domain family member 1) RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
Q6UWF3 SCIMP S76 ochoa SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein) Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}.
Q6ZUS6 CCDC149 S414 ochoa Coiled-coil domain-containing protein 149 None
Q6ZVM7 TOM1L2 S479 ochoa TOM1-like protein 2 (Target of Myb-like protein 2) Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}.
Q7Z3J3 RGPD4 S1232 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z4S6 KIF21A S1271 ochoa Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}.
Q86US8 SMG6 S831 ochoa Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}.
Q8IW50 FAM219A S72 ochoa Protein FAM219A None
Q8IWC1 MAP7D3 S770 ochoa MAP7 domain-containing protein 3 Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.
Q8N1K5 THEMIS S584 ochoa Protein THEMIS (Thymocyte-expressed molecule involved in selection) Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000250|UniProtKB:Q8BGW0}.
Q8N3K9 CMYA5 S2123 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8N960 CEP120 S380 ochoa Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}.
Q8NCF5 NFATC2IP S204 ochoa|psp NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
Q8TD26 CHD6 S21 ochoa Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.
Q8WUB8 PHF10 S331 ochoa PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.
Q8WUY3 PRUNE2 S1803 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q8WWI1 LMO7 S1388 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WWM7 ATXN2L S594 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WXA9 SREK1 S181 ochoa Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}.
Q8WXX5 DNAJC9 S215 ochoa DnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73) Acts as a dual histone chaperone and heat shock co-chaperone (PubMed:33857403). As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes (PubMed:33857403). May also act as a histone co-chaperone together with TONSL (PubMed:33857403). May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers (PubMed:33857403). Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 (PubMed:17182002, PubMed:33857403). As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity (PubMed:33857403). Exhibits activity to assemble histones onto DNA in vitro (PubMed:33857403). {ECO:0000269|PubMed:17182002, ECO:0000269|PubMed:33857403}.
Q92545 TMEM131 S1424 ochoa Transmembrane protein 131 (Protein RW1) Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}.
Q92615 LARP4B S664 ochoa La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.
Q92945 KHSRP S274 ochoa|psp Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.
Q969X0 RILPL2 S107 ochoa RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein) Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). May function via activation of RAC1 and PAK1 (By similarity). {ECO:0000250|UniProtKB:Q6AYA0, ECO:0000250|UniProtKB:Q99LE1}.
Q96BN8 OTULIN S81 ochoa Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327, PubMed:26997266, PubMed:27523608, PubMed:27559085, PubMed:28919039, PubMed:30804083, PubMed:35170849, PubMed:35587511, PubMed:38630025, PubMed:38652464). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334). {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:24726323, ECO:0000269|PubMed:24726327, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27523608, ECO:0000269|PubMed:27559085, ECO:0000269|PubMed:28919039, ECO:0000269|PubMed:30804083, ECO:0000269|PubMed:35170849, ECO:0000269|PubMed:35587511, ECO:0000269|PubMed:38630025, ECO:0000269|PubMed:38652464}.
Q96F24 NRBF2 S120 ochoa|psp Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}.
Q96JM3 CHAMP1 S507 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96PU5 NEDD4L S538 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96SB4 SRPK1 S311 ochoa SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}.
Q96T23 RSF1 S570 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q96T23 RSF1 S629 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q96T58 SPEN S1194 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99640 PKMYT1 S143 ochoa Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
Q99666 RGPD5 T1177 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99666 RGPD5 S1231 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99700 ATXN2 S784 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q99816 TSG101 S309 ochoa Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}.
Q9BQK8 LPIN3 S347 ochoa Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}.
Q9BVJ6 UTP14A S302 ochoa U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) May be required for ribosome biogenesis. {ECO:0000250}.
Q9BVR0 HERC2P3 S315 ochoa Putative HERC2-like protein 3 None
Q9BY89 KIAA1671 S366 ochoa Uncharacterized protein KIAA1671 None
Q9BY89 KIAA1671 S1366 ochoa Uncharacterized protein KIAA1671 None
Q9BYW2 SETD2 S939 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9C0C9 UBE2O S836 ochoa|psp (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}.
Q9H0B6 KLC2 S151 ochoa Kinesin light chain 2 (KLC 2) Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}.
Q9H446 RWDD1 T144 ochoa RWD domain-containing protein 1 (DRG family-regulatory protein 2) Protects DRG2 from proteolytic degradation. {ECO:0000250}.
Q9H4G0 EPB41L1 T30 ochoa Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9HB07 MYG1 S284 ochoa MYG1 exonuclease (EC 3.1.-.-) 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}.
Q9NQG5 RPRD1B Y161 ochoa Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
Q9NQW6 ANLN S388 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NS87 KIF15 S1141 ochoa Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.
Q9NSV4 DIAPH3 S1127 ochoa Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}.
Q9NUA8 ZBTB40 S160 ochoa Zinc finger and BTB domain-containing protein 40 May be involved in transcriptional regulation.
Q9NW68 BSDC1 S92 ochoa BSD domain-containing protein 1 None
Q9NXR5 ANKRD10 S353 ochoa Ankyrin repeat domain-containing protein 10 None
Q9NYF8 BCLAF1 S205 ochoa Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9NZ63 C9orf78 S261 ochoa Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}.
Q9NZB2 FAM120A S638 ochoa Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.
Q9P242 NYAP2 S379 ochoa Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9P260 RELCH S244 ochoa RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}.
Q9P2Y5 UVRAG S522 ochoa|psp UV radiation resistance-associated gene protein (p63) Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}.
Q9UHC7 MKRN1 S127 ochoa E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}.
Q9UKL3 CASP8AP2 S567 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9UKT9 IKZF3 S378 ochoa|psp Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:34155405}.
Q9ULM2 ZNF490 S118 ochoa Zinc finger protein 490 May be involved in transcriptional regulation.
Q9UN86 G3BP2 T227 ochoa|psp Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). {ECO:0000250|UniProtKB:Q13283, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:35977029}.
Q9UPN3 MACF1 S4521 ochoa Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UQR0 SCML2 S499 ochoa|psp Sex comb on midleg-like protein 2 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}.
Q9Y3E1 HDGFL3 S178 ochoa Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) Enhances DNA synthesis and may play a role in cell proliferation. {ECO:0000269|PubMed:10581169}.
Q9Y3X0 CCDC9 S60 ochoa Coiled-coil domain-containing protein 9 Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}.
Q9Y4B5 MTCL1 S685 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y4F1 FARP1 S863 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y5J3 HEY1 S40 ochoa Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1) Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). {ECO:0000250|UniProtKB:Q9WV93, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:25985737}.
Q9Y6Y0 IVNS1ABP S352 ochoa Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein (PubMed:23825951, PubMed:9696811). The BTB and Kelch domains are required for splicing activity (PubMed:30538201). Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF (PubMed:30538201). {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}.
Q6EEV6 SUMO4 S28 Sugiyama Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4) Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916, ECO:0000269|PubMed:16236267}.
P11413 G6PD S106 Sugiyama Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}.
P61163 ACTR1A S247 Sugiyama Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}.
O14910 LIN7A S130 Sugiyama Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.
Q9HAP6 LIN7B S115 Sugiyama Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}.
Q9NUP9 LIN7C S115 Sugiyama Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}.
O43283 MAP3K13 S39 Sugiyama Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
Q9Y281 CFL2 S70 Sugiyama Cofilin-2 (Cofilin, muscle isoform) Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}.
Q15042 RAB3GAP1 Y545 Sugiyama Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:10859313, PubMed:24891604, PubMed:9030515). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129). {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:15696165, ECO:0000269|PubMed:23420520, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9030515, ECO:0000269|PubMed:9852129}.
P11168 SLC2A2 S505 ELM|iPTMNet|EPSD Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2) Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:3399500, ECO:0000269|PubMed:8027028, ECO:0000269|PubMed:8457197}.
P50542 PEX5 S317 Sugiyama Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:11101887, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:17157249, PubMed:17428317, PubMed:21976670, PubMed:26344566, PubMed:7706321, PubMed:7719337, PubMed:7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:17157249, PubMed:21976670, PubMed:26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292). {ECO:0000269|PubMed:11101887, ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:12456682, ECO:0000269|PubMed:16314507, ECO:0000269|PubMed:17157249, ECO:0000269|PubMed:17428317, ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:7706321, ECO:0000269|PubMed:7719337, ECO:0000269|PubMed:7790377}.; FUNCTION: [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129, PubMed:9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232). {ECO:0000269|PubMed:11336669, ECO:0000269|PubMed:11546814, ECO:0000269|PubMed:25538232, ECO:0000269|PubMed:33389129, ECO:0000269|PubMed:9668159}.; FUNCTION: [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal. {ECO:0000269|PubMed:11546814}.
Q14980 NUMA1 S861 Sugiyama Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
P62316 SNRPD2 S35 Sugiyama Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}.
P42025 ACTR1B S247 Sugiyama Beta-centractin (Actin-related protein 1B) (ARP1B) Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
Q9H6T3 RPAP3 S348 Sugiyama RNA polymerase II-associated protein 3 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}.
P0DPB6 POLR1D S78 Sugiyama DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19) DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. {ECO:0000250|UniProtKB:P28000, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:35637192, ECO:0000269|PubMed:36271492}.
Q5T0F9 CC2D1B S209 Sugiyama Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}.
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reactome_id name p -log10_p
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.000410 3.387
R-HSA-6794361 Neurexins and neuroligins 0.000104 3.984
R-HSA-983189 Kinesins 0.000203 3.693
R-HSA-8856688 Golgi-to-ER retrograde transport 0.000500 3.301
R-HSA-9615710 Late endosomal microautophagy 0.000937 3.028
R-HSA-6794362 Protein-protein interactions at synapses 0.001036 2.985
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.001752 2.756
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.001752 2.756
R-HSA-2132295 MHC class II antigen presentation 0.001536 2.813
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.002239 2.650
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.002093 2.679
R-HSA-9613829 Chaperone Mediated Autophagy 0.002890 2.539
R-HSA-9669937 Drug resistance of KIT mutants 0.012037 1.919
R-HSA-9674415 Drug resistance of PDGFR mutants 0.012037 1.919
R-HSA-9669921 KIT mutants bind TKIs 0.012037 1.919
R-HSA-9674428 PDGFR mutants bind TKIs 0.012037 1.919
R-HSA-9674404 Sorafenib-resistant PDGFR mutants 0.012037 1.919
R-HSA-9669934 Sunitinib-resistant KIT mutants 0.012037 1.919
R-HSA-9674401 Sunitinib-resistant PDGFR mutants 0.012037 1.919
R-HSA-9669917 Imatinib-resistant KIT mutants 0.012037 1.919
R-HSA-9669929 Regorafenib-resistant KIT mutants 0.012037 1.919
R-HSA-9669924 Masitinib-resistant KIT mutants 0.012037 1.919
R-HSA-9669936 Sorafenib-resistant KIT mutants 0.012037 1.919
R-HSA-9674396 Imatinib-resistant PDGFR mutants 0.012037 1.919
R-HSA-9674403 Regorafenib-resistant PDGFR mutants 0.012037 1.919
R-HSA-9669914 Dasatinib-resistant KIT mutants 0.012037 1.919
R-HSA-9669926 Nilotinib-resistant KIT mutants 0.012037 1.919
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.011282 1.948
R-HSA-112310 Neurotransmitter release cycle 0.007493 2.125
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.005599 2.252
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.014571 1.837
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.014571 1.837
R-HSA-162599 Late Phase of HIV Life Cycle 0.013915 1.857
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.015534 1.809
R-HSA-9700206 Signaling by ALK in cancer 0.015534 1.809
R-HSA-72163 mRNA Splicing - Major Pathway 0.015820 1.801
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.016842 1.774
R-HSA-72172 mRNA Splicing 0.020187 1.695
R-HSA-9612973 Autophagy 0.020087 1.697
R-HSA-8852135 Protein ubiquitination 0.018983 1.722
R-HSA-162587 HIV Life Cycle 0.020589 1.686
R-HSA-3214841 PKMTs methylate histone lysines 0.021104 1.676
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.023930 1.621
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.023930 1.621
R-HSA-9673013 Diseases of Telomere Maintenance 0.023930 1.621
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.023930 1.621
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.023930 1.621
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.022257 1.653
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.027246 1.565
R-HSA-9675151 Disorders of Developmental Biology 0.027246 1.565
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.025916 1.586
R-HSA-139853 Elevation of cytosolic Ca2+ levels 0.029669 1.528
R-HSA-9663891 Selective autophagy 0.031150 1.507
R-HSA-9680187 Signaling by extracellular domain mutants of KIT 0.035680 1.448
R-HSA-9669935 Signaling by juxtamembrane domain KIT mutants 0.035680 1.448
R-HSA-9669933 Signaling by kinase domain mutants of KIT 0.035680 1.448
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.031790 1.498
R-HSA-9629569 Protein hydroxylation 0.037426 1.427
R-HSA-9018519 Estrogen-dependent gene expression 0.039556 1.403
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.040165 1.396
R-HSA-5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) 0.047289 1.325
R-HSA-6803529 FGFR2 alternative splicing 0.045863 1.339
R-HSA-2980766 Nuclear Envelope Breakdown 0.045242 1.344
R-HSA-1632852 Macroautophagy 0.044323 1.353
R-HSA-191859 snRNP Assembly 0.048704 1.312
R-HSA-194441 Metabolism of non-coding RNA 0.048704 1.312
R-HSA-8941237 Invadopodia formation 0.058760 1.231
R-HSA-9613354 Lipophagy 0.135297 0.869
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.166172 0.779
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.067880 1.168
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.071263 1.147
R-HSA-1433559 Regulation of KIT signaling 0.195950 0.708
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.074699 1.127
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.074699 1.127
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 0.205639 0.687
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 0.205639 0.687
R-HSA-73780 RNA Polymerase III Chain Elongation 0.205639 0.687
R-HSA-1855170 IPs transport between nucleus and cytosol 0.081726 1.088
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.081726 1.088
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.085313 1.069
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.215212 0.667
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.092627 1.033
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.107765 0.968
R-HSA-73980 RNA Polymerase III Transcription Termination 0.243247 0.614
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.111647 0.952
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.111647 0.952
R-HSA-167161 HIV Transcription Initiation 0.119519 0.923
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.119519 0.923
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.261382 0.583
R-HSA-9669938 Signaling by KIT in disease 0.287776 0.541
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 0.287776 0.541
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.114524 0.941
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.212724 0.672
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.212724 0.672
R-HSA-8854518 AURKA Activation by TPX2 0.226005 0.646
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.257187 0.590
R-HSA-380287 Centrosome maturation 0.266118 0.575
R-HSA-383280 Nuclear Receptor transcription pathway 0.279515 0.554
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.297347 0.527
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.337176 0.472
R-HSA-9646399 Aggrephagy 0.111647 0.952
R-HSA-9664873 Pexophagy 0.145713 0.837
R-HSA-9671555 Signaling by PDGFR in disease 0.279084 0.554
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.135650 0.868
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.176218 0.754
R-HSA-9857492 Protein lipoylation 0.205639 0.687
R-HSA-73863 RNA Polymerase I Transcription Termination 0.329697 0.482
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.257187 0.590
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.092627 1.033
R-HSA-73776 RNA Polymerase II Promoter Escape 0.127523 0.894
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.248260 0.605
R-HSA-9033241 Peroxisomal protein import 0.195147 0.710
R-HSA-8849472 PTK6 Down-Regulation 0.081290 1.090
R-HSA-6783984 Glycine degradation 0.224670 0.648
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.119519 0.923
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.123505 0.908
R-HSA-73864 RNA Polymerase I Transcription 0.279515 0.554
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.321514 0.493
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.270585 0.568
R-HSA-5619507 Activation of HOX genes during differentiation 0.167118 0.777
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.167118 0.777
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.177773 0.750
R-HSA-525793 Myogenesis 0.321514 0.493
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.076175 1.118
R-HSA-69478 G2/M DNA replication checkpoint 0.103284 0.986
R-HSA-2470946 Cohesin Loading onto Chromatin 0.114084 0.943
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.145713 0.837
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.186143 0.730
R-HSA-162588 Budding and maturation of HIV virion 0.074699 1.127
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.088947 1.051
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.100115 1.000
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.243247 0.614
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.243247 0.614
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.135650 0.868
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.279084 0.554
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.287776 0.541
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.345769 0.461
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.158381 0.800
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.353661 0.451
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.234893 0.629
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.195950 0.708
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.205639 0.687
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.085313 1.069
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.287776 0.541
R-HSA-3371556 Cellular response to heat stress 0.225266 0.647
R-HSA-418360 Platelet calcium homeostasis 0.067880 1.168
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.234893 0.629
R-HSA-8981373 Intestinal hexose absorption 0.092354 1.035
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.195950 0.708
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.195950 0.708
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.123505 0.908
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.270286 0.568
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.059208 1.228
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 0.304848 0.516
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.304848 0.516
R-HSA-168325 Viral Messenger RNA Synthesis 0.203914 0.691
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.306241 0.514
R-HSA-68877 Mitotic Prometaphase 0.256259 0.591
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.135297 0.869
R-HSA-9932451 SWI/SNF chromatin remodelers 0.313231 0.504
R-HSA-9932444 ATP-dependent chromatin remodelers 0.313231 0.504
R-HSA-5578775 Ion homeostasis 0.182094 0.740
R-HSA-390650 Histamine receptors 0.058760 1.231
R-HSA-180746 Nuclear import of Rev protein 0.088947 1.051
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.169181 0.772
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.243801 0.613
R-HSA-5689603 UCH proteinases 0.270585 0.568
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.252722 0.597
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.354675 0.450
R-HSA-167172 Transcription of the HIV genome 0.234893 0.629
R-HSA-877312 Regulation of IFNG signaling 0.176218 0.754
R-HSA-177243 Interactions of Rev with host cellular proteins 0.111647 0.952
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.111647 0.952
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.115566 0.937
R-HSA-429947 Deadenylation of mRNA 0.304848 0.516
R-HSA-1482801 Acyl chain remodelling of PS 0.313231 0.504
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.321514 0.493
R-HSA-397014 Muscle contraction 0.309845 0.509
R-HSA-68886 M Phase 0.058161 1.235
R-HSA-977606 Regulation of Complement cascade 0.237992 0.623
R-HSA-3214842 HDMs demethylate histones 0.313231 0.504
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.119677 0.922
R-HSA-8953854 Metabolism of RNA 0.157778 0.802
R-HSA-9610379 HCMV Late Events 0.355716 0.449
R-HSA-447041 CHL1 interactions 0.114084 0.943
R-HSA-9754560 SARS-CoV-2 modulates autophagy 0.156004 0.807
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.103920 0.983
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.139756 0.855
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.287776 0.541
R-HSA-8943724 Regulation of PTEN gene transcription 0.199525 0.700
R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.353661 0.451
R-HSA-5578749 Transcriptional regulation by small RNAs 0.252722 0.597
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.248260 0.605
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.061283 1.213
R-HSA-68875 Mitotic Prophase 0.081160 1.091
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.261652 0.582
R-HSA-8963676 Intestinal absorption 0.124754 0.904
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.107765 0.968
R-HSA-5218921 VEGFR2 mediated cell proliferation 0.313231 0.504
R-HSA-77387 Insulin receptor recycling 0.337782 0.471
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.118173 0.927
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.252722 0.597
R-HSA-199991 Membrane Trafficking 0.064634 1.190
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.190782 0.719
R-HSA-4839726 Chromatin organization 0.110331 0.957
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.306241 0.514
R-HSA-9828642 Respiratory syncytial virus genome transcription 0.195950 0.708
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.287776 0.541
R-HSA-75109 Triglyceride biosynthesis 0.329697 0.482
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.337782 0.471
R-HSA-6784531 tRNA processing in the nucleus 0.208314 0.681
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.315113 0.502
R-HSA-166658 Complement cascade 0.316209 0.500
R-HSA-5653656 Vesicle-mediated transport 0.207115 0.684
R-HSA-162906 HIV Infection 0.081460 1.089
R-HSA-8851680 Butyrophilin (BTN) family interactions 0.135297 0.869
R-HSA-175474 Assembly Of The HIV Virion 0.279084 0.554
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.164912 0.783
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.212724 0.672
R-HSA-5693607 Processing of DNA double-strand break ends 0.292894 0.533
R-HSA-3247509 Chromatin modifying enzymes 0.196361 0.707
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.058073 1.236
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.176218 0.754
R-HSA-8876725 Protein methylation 0.205639 0.687
R-HSA-189200 Cellular hexose transport 0.287776 0.541
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.152230 0.817
R-HSA-879518 Organic anion transport by SLCO transporters 0.296364 0.528
R-HSA-1483213 Synthesis of PE 0.329697 0.482
R-HSA-69278 Cell Cycle, Mitotic 0.102389 0.990
R-HSA-1640170 Cell Cycle 0.061042 1.214
R-HSA-982772 Growth hormone receptor signaling 0.296364 0.528
R-HSA-112316 Neuronal System 0.243008 0.614
R-HSA-112315 Transmission across Chemical Synapses 0.237820 0.624
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.199525 0.700
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.199525 0.700
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.199525 0.700
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.199525 0.700
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.071263 1.147
R-HSA-189483 Heme degradation 0.085313 1.069
R-HSA-9705683 SARS-CoV-2-host interactions 0.082669 1.083
R-HSA-6807070 PTEN Regulation 0.293187 0.533
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.092627 1.033
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.130853 0.883
R-HSA-210745 Regulation of gene expression in beta cells 0.067880 1.168
R-HSA-9754706 Atorvastatin ADME 0.215212 0.667
R-HSA-6807004 Negative regulation of MET activity 0.261382 0.583
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.058073 1.236
R-HSA-1280218 Adaptive Immune System 0.060121 1.221
R-HSA-9008059 Interleukin-37 signaling 0.071263 1.147
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.100115 1.000
R-HSA-9694631 Maturation of nucleoprotein 0.252369 0.598
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.287776 0.541
R-HSA-9006925 Intracellular signaling by second messengers 0.276139 0.559
R-HSA-1257604 PIP3 activates AKT signaling 0.334612 0.475
R-HSA-156711 Polo-like kinase mediated events 0.243247 0.614
R-HSA-5654738 Signaling by FGFR2 0.288437 0.540
R-HSA-1169408 ISG15 antiviral mechanism 0.266118 0.575
R-HSA-9012852 Signaling by NOTCH3 0.177773 0.750
R-HSA-196791 Vitamin D (calciferol) metabolism 0.243247 0.614
R-HSA-8939211 ESR-mediated signaling 0.202670 0.693
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.199525 0.700
R-HSA-1980143 Signaling by NOTCH1 0.270585 0.568
R-HSA-9013694 Signaling by NOTCH4 0.261652 0.582
R-HSA-189445 Metabolism of porphyrins 0.248260 0.605
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.225266 0.647
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.253628 0.596
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.345852 0.461
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.337782 0.471
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.319540 0.495
R-HSA-186712 Regulation of beta-cell development 0.195147 0.710
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.319540 0.495
R-HSA-9694516 SARS-CoV-2 Infection 0.162660 0.789
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.335975 0.474
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.243247 0.614
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.287776 0.541
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.158381 0.800
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.221570 0.654
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.309845 0.509
R-HSA-8986944 Transcriptional Regulation by MECP2 0.341565 0.467
R-HSA-9020591 Interleukin-12 signaling 0.270585 0.568
R-HSA-447115 Interleukin-12 family signaling 0.323961 0.490
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.359025 0.445
R-HSA-186763 Downstream signal transduction 0.361459 0.442
R-HSA-399719 Trafficking of AMPA receptors 0.361459 0.442
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.361459 0.442
R-HSA-5633007 Regulation of TP53 Activity 0.365562 0.437
R-HSA-168256 Immune System 0.368532 0.434
R-HSA-9675126 Diseases of mitotic cell cycle 0.369162 0.433
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.369162 0.433
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.369162 0.433
R-HSA-6807878 COPI-mediated anterograde transport 0.372009 0.429
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.376773 0.424
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.376773 0.424
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.376773 0.424
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.376773 0.424
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.376773 0.424
R-HSA-354192 Integrin signaling 0.376773 0.424
R-HSA-9733709 Cardiogenesis 0.376773 0.424
R-HSA-422356 Regulation of insulin secretion 0.380608 0.420
R-HSA-190236 Signaling by FGFR 0.380608 0.420
R-HSA-597592 Post-translational protein modification 0.382354 0.418
R-HSA-390522 Striated Muscle Contraction 0.384293 0.415
R-HSA-114508 Effects of PIP2 hydrolysis 0.384293 0.415
R-HSA-1482788 Acyl chain remodelling of PC 0.384293 0.415
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.384293 0.415
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.384293 0.415
R-HSA-5223345 Miscellaneous transport and binding events 0.384293 0.415
R-HSA-5619102 SLC transporter disorders 0.388431 0.411
R-HSA-70171 Glycolysis 0.389157 0.410
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.391723 0.407
R-HSA-901042 Calnexin/calreticulin cycle 0.391723 0.407
R-HSA-9679506 SARS-CoV Infections 0.397491 0.401
R-HSA-9842860 Regulation of endogenous retroelements 0.397653 0.400
R-HSA-1482839 Acyl chain remodelling of PE 0.399063 0.399
R-HSA-381042 PERK regulates gene expression 0.399063 0.399
R-HSA-212165 Epigenetic regulation of gene expression 0.401454 0.396
R-HSA-9860931 Response of endothelial cells to shear stress 0.406095 0.391
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.406315 0.391
R-HSA-74158 RNA Polymerase III Transcription 0.406315 0.391
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.406315 0.391
R-HSA-9682385 FLT3 signaling in disease 0.406315 0.391
R-HSA-432720 Lysosome Vesicle Biogenesis 0.406315 0.391
R-HSA-8941326 RUNX2 regulates bone development 0.406315 0.391
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.413480 0.384
R-HSA-5696398 Nucleotide Excision Repair 0.414481 0.382
R-HSA-418346 Platelet homeostasis 0.418651 0.378
R-HSA-211000 Gene Silencing by RNA 0.422807 0.374
R-HSA-71336 Pentose phosphate pathway 0.427554 0.369
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.427554 0.369
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.434464 0.362
R-HSA-3371568 Attenuation phase 0.434464 0.362
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.434464 0.362
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.434464 0.362
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.434464 0.362
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.434464 0.362
R-HSA-379726 Mitochondrial tRNA aminoacylation 0.434464 0.362
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.441291 0.355
R-HSA-1483249 Inositol phosphate metabolism 0.443353 0.353
R-HSA-5674135 MAP2K and MAPK activation 0.448036 0.349
R-HSA-9656223 Signaling by RAF1 mutants 0.448036 0.349
R-HSA-9932298 Degradation of CRY and PER proteins 0.448036 0.349
R-HSA-9734767 Developmental Cell Lineages 0.448360 0.348
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.451458 0.345
R-HSA-9855142 Cellular responses to mechanical stimuli 0.451458 0.345
R-HSA-69275 G2/M Transition 0.452474 0.344
R-HSA-379716 Cytosolic tRNA aminoacylation 0.454700 0.342
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.454700 0.342
R-HSA-453274 Mitotic G2-G2/M phases 0.458737 0.338
R-HSA-1433557 Signaling by SCF-KIT 0.461284 0.336
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.461284 0.336
R-HSA-9711123 Cellular response to chemical stress 0.461628 0.336
R-HSA-373760 L1CAM interactions 0.467467 0.330
R-HSA-375280 Amine ligand-binding receptors 0.467789 0.330
R-HSA-9007101 Rab regulation of trafficking 0.471426 0.327
R-HSA-70326 Glucose metabolism 0.471426 0.327
R-HSA-774815 Nucleosome assembly 0.474216 0.324
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.474216 0.324
R-HSA-1489509 DAG and IP3 signaling 0.474216 0.324
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.474216 0.324
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.475367 0.323
R-HSA-5693538 Homology Directed Repair 0.475367 0.323
R-HSA-72165 mRNA Splicing - Minor Pathway 0.480565 0.318
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.480565 0.318
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.480565 0.318
R-HSA-9649948 Signaling downstream of RAS mutants 0.480565 0.318
R-HSA-6802949 Signaling by RAS mutants 0.480565 0.318
R-HSA-75153 Apoptotic execution phase 0.480565 0.318
R-HSA-5357905 Regulation of TNFR1 signaling 0.480565 0.318
R-HSA-1483191 Synthesis of PC 0.486839 0.313
R-HSA-73886 Chromosome Maintenance 0.487085 0.312
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.493037 0.307
R-HSA-9031628 NGF-stimulated transcription 0.493037 0.307
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.494806 0.306
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.494806 0.306
R-HSA-9006931 Signaling by Nuclear Receptors 0.495298 0.305
R-HSA-162909 Host Interactions of HIV factors 0.498639 0.302
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.499160 0.302
R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.499160 0.302
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.506249 0.296
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.506249 0.296
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.506249 0.296
R-HSA-3371571 HSF1-dependent transactivation 0.511187 0.291
R-HSA-109582 Hemostasis 0.512654 0.290
R-HSA-69481 G2/M Checkpoints 0.513785 0.289
R-HSA-73772 RNA Polymerase I Promoter Escape 0.517092 0.286
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.522927 0.282
R-HSA-445355 Smooth Muscle Contraction 0.522927 0.282
R-HSA-8948751 Regulation of PTEN stability and activity 0.522927 0.282
R-HSA-162582 Signal Transduction 0.523200 0.281
R-HSA-449147 Signaling by Interleukins 0.524442 0.280
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.524946 0.280
R-HSA-9824446 Viral Infection Pathways 0.528678 0.277
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.528691 0.277
R-HSA-5576891 Cardiac conduction 0.532291 0.274
R-HSA-3214815 HDACs deacetylate histones 0.534386 0.272
R-HSA-9909396 Circadian clock 0.535934 0.271
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.540012 0.268
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.540012 0.268
R-HSA-75893 TNF signaling 0.540012 0.268
R-HSA-9764561 Regulation of CDH1 Function 0.545571 0.263
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.545571 0.263
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.551063 0.259
R-HSA-163685 Integration of energy metabolism 0.553859 0.257
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.556489 0.255
R-HSA-429914 Deadenylation-dependent mRNA decay 0.556489 0.255
R-HSA-8979227 Triglyceride metabolism 0.556489 0.255
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.557385 0.254
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.561849 0.250
R-HSA-379724 tRNA Aminoacylation 0.561849 0.250
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.561849 0.250
R-HSA-112043 PLC beta mediated events 0.567146 0.246
R-HSA-186797 Signaling by PDGF 0.572378 0.242
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.572378 0.242
R-HSA-8878171 Transcriptional regulation by RUNX1 0.573778 0.241
R-HSA-8848021 Signaling by PTK6 0.577548 0.238
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.577548 0.238
R-HSA-8963743 Digestion and absorption 0.577548 0.238
R-HSA-8856828 Clathrin-mediated endocytosis 0.581515 0.235
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.587701 0.231
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.592686 0.227
R-HSA-199977 ER to Golgi Anterograde Transport 0.594865 0.226
R-HSA-5693606 DNA Double Strand Break Response 0.597612 0.224
R-HSA-112040 G-protein mediated events 0.597612 0.224
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.602478 0.220
R-HSA-446652 Interleukin-1 family signaling 0.611105 0.214
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.612035 0.213
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.612035 0.213
R-HSA-9609507 Protein localization 0.614293 0.212
R-HSA-5693532 DNA Double-Strand Break Repair 0.614293 0.212
R-HSA-427413 NoRC negatively regulates rRNA expression 0.616727 0.210
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.617461 0.209
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.620610 0.207
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.621363 0.207
R-HSA-4086398 Ca2+ pathway 0.625943 0.203
R-HSA-9749641 Aspirin ADME 0.625943 0.203
R-HSA-74160 Gene expression (Transcription) 0.626741 0.203
R-HSA-5619115 Disorders of transmembrane transporters 0.629117 0.201
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.629935 0.201
R-HSA-69473 G2/M DNA damage checkpoint 0.630469 0.200
R-HSA-212436 Generic Transcription Pathway 0.634947 0.197
R-HSA-9609646 HCMV Infection 0.636609 0.196
R-HSA-9694635 Translation of Structural Proteins 0.643720 0.191
R-HSA-9955298 SLC-mediated transport of organic anions 0.648031 0.188
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.650117 0.187
R-HSA-9659379 Sensory processing of sound 0.652290 0.186
R-HSA-69620 Cell Cycle Checkpoints 0.656071 0.183
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.656498 0.183
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.656498 0.183
R-HSA-9833482 PKR-mediated signaling 0.656498 0.183
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.656498 0.183
R-HSA-6806834 Signaling by MET 0.656498 0.183
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.668297 0.175
R-HSA-72306 tRNA processing 0.668297 0.175
R-HSA-9707564 Cytoprotection by HMOX1 0.668820 0.175
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.676683 0.170
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.676683 0.170
R-HSA-6802957 Oncogenic MAPK signaling 0.676790 0.170
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.680703 0.167
R-HSA-141424 Amplification of signal from the kinetochores 0.680703 0.167
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.684568 0.165
R-HSA-76002 Platelet activation, signaling and aggregation 0.692734 0.159
R-HSA-73857 RNA Polymerase II Transcription 0.692842 0.159
R-HSA-168255 Influenza Infection 0.692939 0.159
R-HSA-1236974 ER-Phagosome pathway 0.695889 0.157
R-HSA-3700989 Transcriptional Regulation by TP53 0.703305 0.153
R-HSA-201681 TCF dependent signaling in response to WNT 0.703400 0.153
R-HSA-74752 Signaling by Insulin receptor 0.710356 0.149
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.710356 0.149
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.716060 0.145
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.720755 0.142
R-HSA-5617833 Cilium Assembly 0.720996 0.142
R-HSA-913531 Interferon Signaling 0.723042 0.141
R-HSA-5673001 RAF/MAP kinase cascade 0.724380 0.140
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.727481 0.138
R-HSA-157579 Telomere Maintenance 0.730783 0.136
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.730783 0.136
R-HSA-9609690 HCMV Early Events 0.735374 0.133
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.735374 0.133
R-HSA-1483257 Phospholipid metabolism 0.736310 0.133
R-HSA-5684996 MAPK1/MAPK3 signaling 0.738259 0.132
R-HSA-69618 Mitotic Spindle Checkpoint 0.740452 0.131
R-HSA-195721 Signaling by WNT 0.742122 0.130
R-HSA-2559580 Oxidative Stress Induced Senescence 0.746705 0.127
R-HSA-1483255 PI Metabolism 0.746705 0.127
R-HSA-948021 Transport to the Golgi and subsequent modification 0.749120 0.125
R-HSA-1483206 Glycerophospholipid biosynthesis 0.751351 0.124
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.752809 0.123
R-HSA-111885 Opioid Signalling 0.752809 0.123
R-HSA-9833110 RSV-host interactions 0.755806 0.122
R-HSA-8953897 Cellular responses to stimuli 0.759577 0.119
R-HSA-1236975 Antigen processing-Cross presentation 0.767435 0.115
R-HSA-2672351 Stimuli-sensing channels 0.767435 0.115
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.770256 0.113
R-HSA-9730414 MITF-M-regulated melanocyte development 0.774786 0.111
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.778514 0.109
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.778514 0.109
R-HSA-1280215 Cytokine Signaling in Immune system 0.779226 0.108
R-HSA-68882 Mitotic Anaphase 0.780835 0.107
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.782820 0.106
R-HSA-418990 Adherens junctions interactions 0.784789 0.105
R-HSA-9748784 Drug ADME 0.784789 0.105
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.789067 0.103
R-HSA-8951664 Neddylation 0.790603 0.102
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.791626 0.101
R-HSA-2029485 Role of phospholipids in phagocytosis 0.791626 0.101
R-HSA-909733 Interferon alpha/beta signaling 0.791626 0.101
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.791626 0.101
R-HSA-8878166 Transcriptional regulation by RUNX2 0.801558 0.096
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.806346 0.093
R-HSA-72312 rRNA processing 0.810756 0.091
R-HSA-6809371 Formation of the cornified envelope 0.813312 0.090
R-HSA-2262752 Cellular responses to stress 0.813649 0.090
R-HSA-194138 Signaling by VEGF 0.817818 0.087
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.820030 0.086
R-HSA-114608 Platelet degranulation 0.822215 0.085
R-HSA-5683057 MAPK family signaling cascades 0.823304 0.084
R-HSA-157118 Signaling by NOTCH 0.824314 0.084
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.824374 0.084
R-HSA-9843745 Adipogenesis 0.832752 0.079
R-HSA-6798695 Neutrophil degranulation 0.833028 0.079
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.836791 0.077
R-HSA-73894 DNA Repair 0.840820 0.075
R-HSA-421270 Cell-cell junction organization 0.841537 0.075
R-HSA-3858494 Beta-catenin independent WNT signaling 0.844579 0.073
R-HSA-5688426 Deubiquitination 0.847413 0.072
R-HSA-381119 Unfolded Protein Response (UPR) 0.850177 0.070
R-HSA-416476 G alpha (q) signalling events 0.859919 0.066
R-HSA-69242 S Phase 0.867426 0.062
R-HSA-166520 Signaling by NTRKs 0.867426 0.062
R-HSA-9679191 Potential therapeutics for SARS 0.870631 0.060
R-HSA-73887 Death Receptor Signaling 0.876812 0.057
R-HSA-446728 Cell junction organization 0.877527 0.057
R-HSA-877300 Interferon gamma signaling 0.884127 0.053
R-HSA-9006936 Signaling by TGFB family members 0.885537 0.053
R-HSA-109581 Apoptosis 0.888306 0.051
R-HSA-2467813 Separation of Sister Chromatids 0.891009 0.050
R-HSA-2408522 Selenoamino acid metabolism 0.891009 0.050
R-HSA-5621481 C-type lectin receptors (CLRs) 0.901184 0.045
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.902387 0.045
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.903576 0.044
R-HSA-9664433 Leishmania parasite growth and survival 0.903576 0.044
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.904751 0.043
R-HSA-9678108 SARS-CoV-1 Infection 0.905911 0.043
R-HSA-446203 Asparagine N-linked glycosylation 0.906009 0.043
R-HSA-2559583 Cellular Senescence 0.911505 0.040
R-HSA-1500931 Cell-Cell communication 0.915566 0.038
R-HSA-1852241 Organelle biogenesis and maintenance 0.918854 0.037
R-HSA-983712 Ion channel transport 0.920754 0.036
R-HSA-392499 Metabolism of proteins 0.920859 0.036
R-HSA-1266738 Developmental Biology 0.921428 0.036
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.929547 0.032
R-HSA-389948 Co-inhibition by PD-1 0.930761 0.031
R-HSA-5663205 Infectious disease 0.931711 0.031
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.933265 0.030
R-HSA-5357801 Programmed Cell Death 0.935679 0.029
R-HSA-6805567 Keratinization 0.936464 0.029
R-HSA-1643685 Disease 0.938435 0.028
R-HSA-425407 SLC-mediated transmembrane transport 0.963287 0.016
R-HSA-388841 Regulation of T cell activation by CD28 family 0.965652 0.015
R-HSA-168249 Innate Immune System 0.969131 0.014
R-HSA-9824443 Parasitic Infection Pathways 0.974764 0.011
R-HSA-9658195 Leishmania infection 0.974764 0.011
R-HSA-8957322 Metabolism of steroids 0.985166 0.006
R-HSA-1474244 Extracellular matrix organization 0.986397 0.006
R-HSA-422475 Axon guidance 0.992441 0.003
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.993850 0.003
R-HSA-418594 G alpha (i) signalling events 0.994768 0.002
R-HSA-9675108 Nervous system development 0.994969 0.002
R-HSA-72766 Translation 0.996022 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 0.996627 0.001
R-HSA-382551 Transport of small molecules 0.998359 0.001
R-HSA-388396 GPCR downstream signalling 0.999426 0.000
R-HSA-500792 GPCR ligand binding 0.999463 0.000
R-HSA-372790 Signaling by GPCR 0.999781 0.000
R-HSA-556833 Metabolism of lipids 0.999993 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDK1CDK1 0.883 0.786 1 0.934
KISKIS 0.879 0.697 1 0.919
CDK3CDK3 0.878 0.727 1 0.944
P38GP38G 0.875 0.796 1 0.947
CDK8CDK8 0.874 0.750 1 0.932
CDK19CDK19 0.873 0.744 1 0.942
CDK18CDK18 0.873 0.763 1 0.941
CDK17CDK17 0.872 0.778 1 0.941
JNK2JNK2 0.871 0.792 1 0.942
P38BP38B 0.870 0.773 1 0.933
CDK5CDK5 0.869 0.744 1 0.912
CLK3CLK3 0.868 0.490 1 0.753
JNK3JNK3 0.868 0.784 1 0.940
ERK1ERK1 0.868 0.762 1 0.936
P38DP38D 0.867 0.775 1 0.945
CDK16CDK16 0.863 0.749 1 0.940
CDK13CDK13 0.863 0.729 1 0.937
P38AP38A 0.861 0.740 1 0.901
CDK7CDK7 0.860 0.710 1 0.930
HIPK2HIPK2 0.859 0.664 1 0.919
CDK12CDK12 0.858 0.725 1 0.941
NLKNLK 0.857 0.644 1 0.787
ERK2ERK2 0.856 0.742 1 0.917
CDK2CDK2 0.855 0.611 1 0.878
DYRK2DYRK2 0.852 0.635 1 0.892
JNK1JNK1 0.852 0.710 1 0.944
ERK5ERK5 0.851 0.383 1 0.716
COTCOT 0.850 0.045 2 0.893
CDK14CDK14 0.850 0.708 1 0.928
MTORMTOR 0.849 0.251 1 0.621
CDK9CDK9 0.848 0.691 1 0.937
HIPK4HIPK4 0.846 0.397 1 0.746
DYRK4DYRK4 0.846 0.653 1 0.939
HIPK1HIPK1 0.845 0.585 1 0.889
CDK10CDK10 0.843 0.663 1 0.929
SRPK1SRPK1 0.841 0.278 -3 0.694
DYRK1BDYRK1B 0.839 0.614 1 0.916
CDK6CDK6 0.839 0.691 1 0.931
ICKICK 0.839 0.326 -3 0.790
MOSMOS 0.839 0.042 1 0.532
CDK4CDK4 0.838 0.704 1 0.944
DYRK1ADYRK1A 0.836 0.513 1 0.879
CDKL1CDKL1 0.835 0.125 -3 0.750
DSTYKDSTYK 0.833 -0.035 2 0.907
PRPKPRPK 0.833 -0.099 -1 0.851
CDKL5CDKL5 0.833 0.149 -3 0.739
CDC7CDC7 0.832 -0.086 1 0.482
NEK6NEK6 0.831 0.007 -2 0.869
CLK2CLK2 0.830 0.346 -3 0.694
HIPK3HIPK3 0.830 0.546 1 0.861
GRK7GRK7 0.830 0.097 1 0.484
SRPK2SRPK2 0.829 0.220 -3 0.617
PIM3PIM3 0.828 -0.031 -3 0.795
CLK1CLK1 0.828 0.333 -3 0.687
PRP4PRP4 0.828 0.397 -3 0.729
ATRATR 0.828 -0.042 1 0.499
CLK4CLK4 0.828 0.298 -3 0.709
BMPR2BMPR2 0.827 -0.129 -2 0.876
TBK1TBK1 0.827 -0.140 1 0.432
MAKMAK 0.827 0.463 -2 0.779
GRK1GRK1 0.827 0.035 -2 0.774
CAMK1BCAMK1B 0.826 -0.049 -3 0.810
NEK7NEK7 0.826 -0.080 -3 0.848
NDR2NDR2 0.825 -0.024 -3 0.812
CAMK2GCAMK2G 0.825 -0.075 2 0.810
IKKAIKKA 0.825 -0.026 -2 0.706
RAF1RAF1 0.824 -0.185 1 0.476
MST4MST4 0.824 0.000 2 0.899
IKKEIKKE 0.824 -0.147 1 0.429
NUAK2NUAK2 0.824 0.015 -3 0.795
CHAK2CHAK2 0.823 -0.033 -1 0.829
PDHK4PDHK4 0.823 -0.207 1 0.542
IKKBIKKB 0.823 -0.150 -2 0.703
GCN2GCN2 0.823 -0.179 2 0.836
SRPK3SRPK3 0.822 0.181 -3 0.666
PKN3PKN3 0.822 -0.046 -3 0.775
DYRK3DYRK3 0.822 0.434 1 0.858
ULK2ULK2 0.821 -0.182 2 0.844
MLK1MLK1 0.821 -0.086 2 0.874
BMPR1BBMPR1B 0.820 0.009 1 0.441
NIKNIK 0.820 -0.090 -3 0.836
PIM1PIM1 0.819 0.010 -3 0.735
PKCDPKCD 0.818 0.000 2 0.860
HUNKHUNK 0.818 -0.121 2 0.854
PRKD1PRKD1 0.818 -0.025 -3 0.784
GSK3AGSK3A 0.818 0.228 4 0.489
MARK4MARK4 0.817 -0.024 4 0.911
SKMLCKSKMLCK 0.817 -0.077 -2 0.837
TGFBR2TGFBR2 0.817 -0.085 -2 0.816
GRK6GRK6 0.816 -0.088 1 0.476
RSK2RSK2 0.816 -0.030 -3 0.721
TGFBR1TGFBR1 0.816 -0.021 -2 0.800
GRK5GRK5 0.815 -0.156 -3 0.817
PDHK1PDHK1 0.815 -0.231 1 0.521
CAMLCKCAMLCK 0.815 -0.074 -2 0.819
MLK3MLK3 0.815 -0.006 2 0.821
AMPKA1AMPKA1 0.815 -0.060 -3 0.810
NDR1NDR1 0.814 -0.082 -3 0.791
LATS1LATS1 0.814 0.015 -3 0.827
WNK1WNK1 0.814 -0.115 -2 0.855
PKN2PKN2 0.814 -0.074 -3 0.783
DLKDLK 0.814 -0.168 1 0.492
NEK9NEK9 0.814 -0.149 2 0.893
PLK1PLK1 0.813 -0.062 -2 0.840
ULK1ULK1 0.813 -0.169 -3 0.800
DAPK2DAPK2 0.813 -0.107 -3 0.820
ATMATM 0.813 -0.059 1 0.435
P90RSKP90RSK 0.813 -0.044 -3 0.723
ALK4ALK4 0.812 -0.051 -2 0.818
FAM20CFAM20C 0.811 0.014 2 0.587
PRKD2PRKD2 0.811 -0.028 -3 0.731
BCKDKBCKDK 0.811 -0.143 -1 0.830
GRK4GRK4 0.811 -0.112 -2 0.820
MLK2MLK2 0.811 -0.124 2 0.874
ANKRD3ANKRD3 0.810 -0.163 1 0.490
RSK3RSK3 0.810 -0.058 -3 0.715
TSSK1TSSK1 0.810 -0.034 -3 0.830
RIPK3RIPK3 0.810 -0.193 3 0.702
ERK7ERK7 0.810 0.223 2 0.560
VRK2VRK2 0.809 -0.010 1 0.574
MASTLMASTL 0.809 -0.229 -2 0.796
TSSK2TSSK2 0.809 -0.076 -5 0.811
ACVR2BACVR2B 0.809 -0.042 -2 0.808
P70S6KBP70S6KB 0.808 -0.063 -3 0.742
ACVR2AACVR2A 0.807 -0.046 -2 0.797
YSK4YSK4 0.807 -0.127 1 0.454
MOKMOK 0.807 0.384 1 0.800
NUAK1NUAK1 0.807 -0.026 -3 0.743
AMPKA2AMPKA2 0.807 -0.060 -3 0.776
MEK1MEK1 0.806 -0.131 2 0.880
ALK2ALK2 0.806 -0.047 -2 0.811
LATS2LATS2 0.806 -0.083 -5 0.731
PKRPKR 0.806 -0.100 1 0.480
PINK1PINK1 0.806 0.133 1 0.627
PKCBPKCB 0.806 -0.019 2 0.821
MLK4MLK4 0.806 -0.058 2 0.786
PKACGPKACG 0.806 -0.069 -2 0.735
PLK3PLK3 0.806 -0.061 2 0.773
DNAPKDNAPK 0.805 -0.036 1 0.425
CAMK2BCAMK2B 0.805 -0.052 2 0.759
CAMK2DCAMK2D 0.805 -0.136 -3 0.795
WNK3WNK3 0.805 -0.260 1 0.463
TTBK2TTBK2 0.804 -0.194 2 0.760
IRE1IRE1 0.804 -0.128 1 0.440
NIM1NIM1 0.804 -0.095 3 0.746
TAO3TAO3 0.803 0.011 1 0.494
BMPR1ABMPR1A 0.803 -0.016 1 0.425
PKCAPKCA 0.803 -0.020 2 0.813
RSK4RSK4 0.803 -0.025 -3 0.699
TLK2TLK2 0.803 -0.101 1 0.429
QSKQSK 0.803 -0.017 4 0.887
CAMK2ACAMK2A 0.802 -0.041 2 0.782
PKCGPKCG 0.802 -0.042 2 0.815
SMG1SMG1 0.801 -0.091 1 0.466
MAPKAPK2MAPKAPK2 0.801 -0.065 -3 0.688
IRE2IRE2 0.801 -0.095 2 0.819
PLK4PLK4 0.800 -0.092 2 0.679
AURCAURC 0.800 -0.039 -2 0.641
RIPK1RIPK1 0.800 -0.266 1 0.446
MEKK1MEKK1 0.799 -0.119 1 0.476
MAPKAPK3MAPKAPK3 0.799 -0.127 -3 0.731
NEK2NEK2 0.799 -0.148 2 0.870
CHAK1CHAK1 0.799 -0.146 2 0.830
MPSK1MPSK1 0.799 0.045 1 0.504
MEKK3MEKK3 0.799 -0.133 1 0.475
PASKPASK 0.799 -0.017 -3 0.822
PKCHPKCH 0.799 -0.064 2 0.810
MEKK2MEKK2 0.799 -0.076 2 0.864
ZAKZAK 0.799 -0.122 1 0.463
PKCZPKCZ 0.799 -0.077 2 0.843
GRK2GRK2 0.799 -0.081 -2 0.693
GSK3BGSK3B 0.798 0.067 4 0.479
PRKD3PRKD3 0.798 -0.053 -3 0.691
MST3MST3 0.798 -0.034 2 0.891
CK1ECK1E 0.797 -0.013 -3 0.548
PAK1PAK1 0.797 -0.107 -2 0.748
MSK2MSK2 0.797 -0.094 -3 0.694
MARK2MARK2 0.797 -0.021 4 0.836
CAMK4CAMK4 0.797 -0.166 -3 0.771
PKACBPKACB 0.797 -0.025 -2 0.665
MNK2MNK2 0.797 -0.084 -2 0.769
SIKSIK 0.797 -0.043 -3 0.714
NEK5NEK5 0.797 -0.116 1 0.460
QIKQIK 0.796 -0.115 -3 0.789
GAKGAK 0.796 0.005 1 0.531
MARK3MARK3 0.795 -0.023 4 0.863
BRAFBRAF 0.795 -0.130 -4 0.763
PHKG1PHKG1 0.795 -0.114 -3 0.782
SGK3SGK3 0.794 -0.055 -3 0.705
PRKXPRKX 0.794 0.009 -3 0.636
MEK5MEK5 0.794 -0.195 2 0.875
CHK1CHK1 0.794 -0.084 -3 0.799
AKT2AKT2 0.794 -0.025 -3 0.633
MELKMELK 0.793 -0.129 -3 0.754
PAK3PAK3 0.793 -0.148 -2 0.740
PKG2PKG2 0.793 -0.049 -2 0.670
MNK1MNK1 0.793 -0.078 -2 0.781
CK2A2CK2A2 0.792 -0.003 1 0.411
MSK1MSK1 0.792 -0.074 -3 0.694
DRAK1DRAK1 0.792 -0.159 1 0.415
HRIHRI 0.790 -0.180 -2 0.846
DCAMKL1DCAMKL1 0.790 -0.089 -3 0.742
CK1DCK1D 0.790 -0.000 -3 0.495
MYLK4MYLK4 0.790 -0.100 -2 0.737
PAK6PAK6 0.790 -0.053 -2 0.646
TLK1TLK1 0.790 -0.147 -2 0.837
PIM2PIM2 0.789 -0.044 -3 0.689
PLK2PLK2 0.789 0.008 -3 0.816
AURAAURA 0.789 -0.071 -2 0.598
PERKPERK 0.789 -0.190 -2 0.836
GCKGCK 0.789 -0.048 1 0.463
CAMK1GCAMK1G 0.789 -0.095 -3 0.703
TAO2TAO2 0.788 -0.065 2 0.906
AURBAURB 0.788 -0.077 -2 0.633
PAK2PAK2 0.787 -0.152 -2 0.727
MST2MST2 0.787 -0.070 1 0.463
NEK11NEK11 0.787 -0.152 1 0.475
MARK1MARK1 0.787 -0.080 4 0.874
BRSK1BRSK1 0.787 -0.105 -3 0.743
IRAK4IRAK4 0.786 -0.168 1 0.431
EEF2KEEF2K 0.786 -0.049 3 0.856
MAP3K15MAP3K15 0.786 -0.091 1 0.466
CK1A2CK1A2 0.785 -0.022 -3 0.493
DCAMKL2DCAMKL2 0.785 -0.093 -3 0.763
GRK3GRK3 0.785 -0.078 -2 0.649
NEK8NEK8 0.785 -0.159 2 0.873
SSTKSSTK 0.785 -0.064 4 0.868
BRSK2BRSK2 0.785 -0.130 -3 0.766
TNIKTNIK 0.784 -0.027 3 0.861
PDK1PDK1 0.784 -0.106 1 0.482
WNK4WNK4 0.784 -0.190 -2 0.842
PKCTPKCT 0.784 -0.084 2 0.817
CK1G1CK1G1 0.782 -0.062 -3 0.533
SMMLCKSMMLCK 0.782 -0.109 -3 0.759
MINKMINK 0.782 -0.101 1 0.447
LKB1LKB1 0.782 -0.122 -3 0.821
CK2A1CK2A1 0.782 -0.019 1 0.398
CAMKK1CAMKK1 0.781 -0.205 -2 0.733
HGKHGK 0.781 -0.078 3 0.856
PKACAPKACA 0.781 -0.042 -2 0.613
AKT1AKT1 0.780 -0.053 -3 0.653
MAPKAPK5MAPKAPK5 0.779 -0.167 -3 0.662
LRRK2LRRK2 0.778 -0.095 2 0.887
MST1MST1 0.778 -0.099 1 0.452
PKCEPKCE 0.778 -0.030 2 0.807
PHKG2PHKG2 0.778 -0.122 -3 0.738
PKCIPKCI 0.778 -0.083 2 0.817
MEKK6MEKK6 0.777 -0.149 1 0.473
KHS1KHS1 0.777 -0.052 1 0.453
KHS2KHS2 0.777 -0.019 1 0.462
SNRKSNRK 0.777 -0.243 2 0.723
HPK1HPK1 0.777 -0.094 1 0.458
NEK4NEK4 0.777 -0.180 1 0.439
CAMKK2CAMKK2 0.777 -0.189 -2 0.726
NEK1NEK1 0.776 -0.147 1 0.441
TAK1TAK1 0.776 -0.159 1 0.443
VRK1VRK1 0.776 -0.162 2 0.886
DAPK3DAPK3 0.775 -0.096 -3 0.750
CAMK1DCAMK1D 0.775 -0.087 -3 0.638
SGK1SGK1 0.774 -0.015 -3 0.552
P70S6KP70S6K 0.774 -0.105 -3 0.647
TTBK1TTBK1 0.773 -0.204 2 0.674
OSR1OSR1 0.773 -0.039 2 0.851
PBKPBK 0.772 -0.059 1 0.487
BUB1BUB1 0.772 0.007 -5 0.771
LOKLOK 0.772 -0.115 -2 0.750
SLKSLK 0.772 -0.097 -2 0.695
TTKTTK 0.770 -0.031 -2 0.857
YSK1YSK1 0.770 -0.118 2 0.872
IRAK1IRAK1 0.769 -0.286 -1 0.722
AKT3AKT3 0.769 -0.040 -3 0.573
PDHK3_TYRPDHK3_TYR 0.768 0.183 4 0.919
DAPK1DAPK1 0.768 -0.103 -3 0.729
PAK5PAK5 0.768 -0.104 -2 0.590
PKN1PKN1 0.767 -0.091 -3 0.664
MEK2MEK2 0.767 -0.225 2 0.864
PAK4PAK4 0.767 -0.085 -2 0.600
MRCKAMRCKA 0.767 -0.075 -3 0.698
ROCK2ROCK2 0.767 -0.069 -3 0.734
HASPINHASPIN 0.766 -0.022 -1 0.668
SBKSBK 0.766 0.035 -3 0.515
MRCKBMRCKB 0.766 -0.066 -3 0.678
STK33STK33 0.765 -0.169 2 0.656
BIKEBIKE 0.764 -0.025 1 0.481
CAMK1ACAMK1A 0.763 -0.072 -3 0.598
ALPHAK3ALPHAK3 0.763 -0.060 -1 0.778
DMPK1DMPK1 0.763 -0.031 -3 0.701
CHK2CHK2 0.763 -0.083 -3 0.574
RIPK2RIPK2 0.762 -0.262 1 0.430
PDHK4_TYRPDHK4_TYR 0.761 0.093 2 0.879
ASK1ASK1 0.761 -0.145 1 0.467
MYO3AMYO3A 0.760 -0.068 1 0.446
MAP2K6_TYRMAP2K6_TYR 0.759 0.059 -1 0.889
NEK3NEK3 0.758 -0.177 1 0.455
TAO1TAO1 0.757 -0.097 1 0.441
MYO3BMYO3B 0.757 -0.091 2 0.881
MAP2K4_TYRMAP2K4_TYR 0.757 0.012 -1 0.880
AAK1AAK1 0.757 0.021 1 0.444
BMPR2_TYRBMPR2_TYR 0.756 0.037 -1 0.880
TESK1_TYRTESK1_TYR 0.756 -0.022 3 0.861
PDHK1_TYRPDHK1_TYR 0.754 -0.010 -1 0.886
PKMYT1_TYRPKMYT1_TYR 0.753 0.047 3 0.812
MAP2K7_TYRMAP2K7_TYR 0.753 -0.102 2 0.886
CRIKCRIK 0.752 -0.058 -3 0.653
ROCK1ROCK1 0.751 -0.086 -3 0.693
LIMK2_TYRLIMK2_TYR 0.751 0.044 -3 0.855
YANK3YANK3 0.750 -0.071 2 0.406
PINK1_TYRPINK1_TYR 0.750 -0.106 1 0.531
CK1ACK1A 0.750 -0.045 -3 0.409
STLK3STLK3 0.749 -0.174 1 0.437
PKG1PKG1 0.748 -0.090 -2 0.585
LIMK1_TYRLIMK1_TYR 0.743 -0.069 2 0.899
EPHA6EPHA6 0.743 -0.089 -1 0.859
RETRET 0.742 -0.164 1 0.492
TYK2TYK2 0.741 -0.183 1 0.479
TXKTXK 0.741 -0.037 1 0.472
EPHB4EPHB4 0.740 -0.111 -1 0.843
CSF1RCSF1R 0.740 -0.094 3 0.727
JAK2JAK2 0.739 -0.132 1 0.496
MST1RMST1R 0.739 -0.152 3 0.750
ROS1ROS1 0.738 -0.138 3 0.724
YES1YES1 0.738 -0.086 -1 0.805
DDR1DDR1 0.737 -0.152 4 0.858
JAK3JAK3 0.737 -0.121 1 0.486
TYRO3TYRO3 0.735 -0.183 3 0.753
FGRFGR 0.735 -0.150 1 0.486
INSRRINSRR 0.735 -0.124 3 0.706
FGFR2FGFR2 0.734 -0.079 3 0.754
ABL2ABL2 0.734 -0.115 -1 0.792
FERFER 0.733 -0.175 1 0.491
JAK1JAK1 0.732 -0.087 1 0.457
BLKBLK 0.732 -0.050 -1 0.807
NEK10_TYRNEK10_TYR 0.732 -0.127 1 0.426
TNNI3K_TYRTNNI3K_TYR 0.731 -0.050 1 0.505
CK1G3CK1G3 0.731 -0.050 -3 0.362
EPHA4EPHA4 0.731 -0.102 2 0.764
HCKHCK 0.730 -0.136 -1 0.794
LCKLCK 0.730 -0.082 -1 0.794
FGFR1FGFR1 0.730 -0.083 3 0.713
ABL1ABL1 0.730 -0.133 -1 0.777
EPHB1EPHB1 0.730 -0.157 1 0.470
KDRKDR 0.729 -0.113 3 0.694
KITKIT 0.729 -0.141 3 0.736
FLT3FLT3 0.728 -0.166 3 0.740
EPHB2EPHB2 0.728 -0.132 -1 0.817
METMET 0.728 -0.108 3 0.727
FYNFYN 0.727 -0.050 -1 0.772
PDGFRBPDGFRB 0.727 -0.211 3 0.756
EPHB3EPHB3 0.727 -0.157 -1 0.830
TNK2TNK2 0.727 -0.158 3 0.721
ITKITK 0.726 -0.154 -1 0.774
FGFR3FGFR3 0.725 -0.081 3 0.723
TNK1TNK1 0.725 -0.131 3 0.719
TEKTEK 0.724 -0.099 3 0.693
DDR2DDR2 0.724 -0.047 3 0.712
FLT1FLT1 0.724 -0.123 -1 0.841
SRMSSRMS 0.724 -0.204 1 0.468
EGFREGFR 0.723 -0.078 1 0.428
WEE1_TYRWEE1_TYR 0.722 -0.104 -1 0.733
ERBB2ERBB2 0.721 -0.159 1 0.472
BTKBTK 0.721 -0.202 -1 0.734
BMXBMX 0.721 -0.126 -1 0.703
MERTKMERTK 0.720 -0.179 3 0.706
YANK2YANK2 0.720 -0.089 2 0.426
TECTEC 0.720 -0.148 -1 0.707
AXLAXL 0.719 -0.212 3 0.715
PDGFRAPDGFRA 0.719 -0.244 3 0.754
CK1G2CK1G2 0.719 -0.039 -3 0.454
EPHA7EPHA7 0.719 -0.141 2 0.781
INSRINSR 0.719 -0.163 3 0.679
FRKFRK 0.718 -0.135 -1 0.815
NTRK1NTRK1 0.718 -0.221 -1 0.821
EPHA3EPHA3 0.717 -0.163 2 0.747
ALKALK 0.717 -0.190 3 0.676
PTK2PTK2 0.717 -0.038 -1 0.791
NTRK3NTRK3 0.717 -0.150 -1 0.780
SYKSYK 0.716 -0.046 -1 0.785
FLT4FLT4 0.716 -0.180 3 0.692
NTRK2NTRK2 0.716 -0.216 3 0.690
EPHA8EPHA8 0.715 -0.106 -1 0.816
SRCSRC 0.715 -0.110 -1 0.766
FGFR4FGFR4 0.714 -0.096 -1 0.762
LYNLYN 0.714 -0.140 3 0.655
MATKMATK 0.713 -0.117 -1 0.726
EPHA5EPHA5 0.713 -0.140 2 0.751
PTK6PTK6 0.713 -0.234 -1 0.700
LTKLTK 0.713 -0.210 3 0.688
ERBB4ERBB4 0.709 -0.074 1 0.430
EPHA1EPHA1 0.709 -0.219 3 0.695
PTK2BPTK2B 0.708 -0.159 -1 0.729
CSKCSK 0.708 -0.154 2 0.783
MUSKMUSK 0.707 -0.139 1 0.412
IGF1RIGF1R 0.704 -0.145 3 0.618
EPHA2EPHA2 0.704 -0.132 -1 0.782
ZAP70ZAP70 0.697 -0.053 -1 0.711
FESFES 0.686 -0.173 -1 0.672