Motif 774 (n=177)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A075B6Q4 | None | S72 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000256|ARBA:ARBA00043887}. |
| A6NKT7 | RGPD3 | S919 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| E9PCH4 | None | S1464 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O00232 | PSMD12 | S335 | ochoa | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O00571 | DDX3X | S410 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14628 | ZNF195 | S394 | ochoa | Zinc finger protein 195 | May be involved in transcriptional regulation. |
| O14715 | RGPD8 | S918 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15523 | DDX3Y | S408 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43264 | ZW10 | S356 | ochoa | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| O43581 | SYT7 | S52 | ochoa | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) | Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. |
| O43776 | NARS1 | S48 | ochoa | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) | Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}. |
| O43815 | STRN | S204 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60218 | AKR1B10 | S118 | ochoa | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}. |
| O60264 | SMARCA5 | S710 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60503 | ADCY9 | S27 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O75083 | WDR1 | S310 | ochoa | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}. |
| O75145 | PPFIA3 | S1125 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75152 | ZC3H11A | S452 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75164 | KDM4A | S1019 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O76094 | SRP72 | S524 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O94806 | PRKD3 | S391 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94913 | PCF11 | S325 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| P00390 | GSR | S444 | ochoa | Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) | Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol. {ECO:0000269|PubMed:17185460}. |
| P00441 | SOD1 | S103 | ochoa | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P02144 | MB | S59 | ochoa | Myoglobin (Nitrite reductase MB) (EC 1.7.-.-) (Pseudoperoxidase MB) (EC 1.11.1.-) | Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218). {ECO:0000269|PubMed:30918256, ECO:0000269|PubMed:32891753, ECO:0000269|PubMed:34679218}. |
| P04406 | GAPDH | S292 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P05783 | KRT18 | S242 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P07814 | EPRS1 | S954 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P10412 | H1-4 | S102 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P12259 | F5 | S1516 | ochoa | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| P15311 | EZR | T299 | ochoa | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P16401 | H1-5 | S105 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S103 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S102 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16615 | ATP2A2 | S608 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P16949 | STMN1 | S63 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P21796 | VDAC1 | S44 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P22234 | PAICS | S276 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P22492 | H1-6 | S106 | ochoa | Histone H1t (Testicular H1 histone) | Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). {ECO:0000269|PubMed:26757249, ECO:0000305}. |
| P24385 | CCND1 | S41 | ochoa | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8302605). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529). {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:1827756, ECO:0000269|PubMed:1833066, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19412162, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:8114739, ECO:0000269|PubMed:8302605, ECO:0000269|PubMed:9106657}. |
| P24723 | PRKCH | S320 | ochoa | Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}. |
| P25054 | APC | S2396 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26038 | MSN | T299 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P26232 | CTNNA2 | S901 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P28370 | SMARCA1 | S725 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) | [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}. |
| P30533 | LRPAP1 | S137 | ochoa | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P33981 | TTK | S742 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35240 | NF2 | S315 | ochoa|psp | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P35241 | RDX | T299 | ochoa | Radixin | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| P35251 | RFC1 | S173 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35269 | GTF2F1 | S65 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P42566 | EPS15 | S746 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42684 | ABL2 | S819 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46063 | RECQL | S597 | ochoa | ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1) | DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977). {ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:19151156, ECO:0000269|PubMed:25831490, ECO:0000269|PubMed:35025765, ECO:0000269|PubMed:7527136, ECO:0000269|PubMed:7961977, ECO:0000269|PubMed:8056767}. |
| P46100 | ATRX | S1253 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P48651 | PTDSS1 | S417 | ochoa | Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269|PubMed:19014349, ECO:0000269|PubMed:24241535}. |
| P49792 | RANBP2 | S1894 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50461 | CSRP3 | S108 | ochoa | Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein) | Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:19752190, ECO:0000269|PubMed:24934443, ECO:0000269|PubMed:27353086}.; FUNCTION: [Isoform 2]: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. {ECO:0000269|PubMed:24860983}. |
| P51911 | CNN1 | S175 | ochoa | Calponin-1 (Basic calponin) (Calponin H1, smooth muscle) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}. |
| P54132 | BLM | S168 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54278 | PMS2 | S603 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P61421 | ATP6V0D1 | S283 | ochoa | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1) | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250|UniProtKB:P51863, ECO:0000250|UniProtKB:Q6PGV1, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:33065002}. |
| P61981 | YWHAG | S71 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P78345 | RPP38 | S226 | ochoa | Ribonuclease P protein subunit p38 (RNaseP protein p38) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}. |
| P78345 | RPP38 | S253 | ochoa | Ribonuclease P protein subunit p38 (RNaseP protein p38) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}. |
| P78527 | PRKDC | S2789 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P84090 | ERH | S24 | ochoa | Enhancer of rudimentary homolog | May have a role in the cell cycle. |
| Q00534 | CDK6 | S290 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q00688 | FKBP3 | S77 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q00872 | MYBPC1 | S366 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q02539 | H1-1 | S105 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q02878 | RPL6 | S143 | ochoa | Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.; FUNCTION: (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). {ECO:0000269|PubMed:8457378}. |
| Q03164 | KMT2A | S2420 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S2729 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03468 | ERCC6 | S158 | ochoa|psp | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q03468 | ERCC6 | S489 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q05682 | CALD1 | S129 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q09666 | AHNAK | S4486 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13017 | ARHGAP5 | S1218 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13136 | PPFIA1 | S234 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q14203 | DCTN1 | S541 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q15054 | POLD3 | S269 | ochoa | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15746 | MYLK | S1122 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16513 | PKN2 | S29 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q5JUX0 | SPIN3 | S195 | ochoa | Spindlin-3 (Spindlin-like protein 3) (SPIN-3) | Exhibits H3K4me3-binding activity. {ECO:0000269|PubMed:29061846}. |
| Q5SSJ5 | HP1BP3 | S225 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T8P6 | RBM26 | S90 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5TDH0 | DDI2 | S150 | ochoa | Protein DDI1 homolog 2 (EC 3.4.23.-) | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q5UIP0 | RIF1 | S2339 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VU43 | PDE4DIP | S1321 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VUB5 | FAM171A1 | S450 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VWN6 | TASOR2 | S1530 | ochoa | Protein TASOR 2 | None |
| Q6AI08 | HEATR6 | S499 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6FIF0 | ZFAND6 | S123 | ochoa | AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}. |
| Q6PJW8 | CNST | S293 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6R327 | RICTOR | S1177 | ochoa|psp | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6WCQ1 | MPRIP | S980 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZVD7 | STOX1 | S392 | ochoa | Storkhead-box protein 1 (Winged-helix domain-containing protein) | Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:24738702}.; FUNCTION: [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177). {ECO:0000269|PubMed:22253775, ECO:0000269|PubMed:22995177}. |
| Q7Z2T5 | TRMT1L | S707 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q7Z3J3 | RGPD4 | S919 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z5K2 | WAPL | S158 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z7A4 | PXK | S448 | ochoa | PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA) | Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. {ECO:0000250|UniProtKB:Q8BX57, ECO:0000303|PubMed:16142408}. |
| Q86X10 | RALGAPB | S1022 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q8N4S0 | CCDC82 | S219 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8N556 | AFAP1 | S548 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8NCN4 | RNF169 | S508 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NEM7 | SUPT20H | S296 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8TEU7 | RAPGEF6 | S1414 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WVM8 | SCFD1 | S298 | ochoa | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WWI1 | LMO7 | S1034 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q96DR7 | ARHGEF26 | S740 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96GA3 | LTV1 | S248 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96JB1 | DNAH8 | S3112 | ochoa | Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8) | Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. {ECO:0000269|PubMed:32619401}. |
| Q96NR8 | RDH12 | S175 | ochoa | Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:15865448, PubMed:19686838). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:12226107, PubMed:15865448). {ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:19686838}. |
| Q96S38 | RPS6KC1 | S608 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99081 | TCF12 | S508 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99250 | SCN2A | S1968 | ochoa | Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). {ECO:0000250|UniProtKB:B1AWN6, ECO:0000269|PubMed:1325650, ECO:0000269|PubMed:17021166, ECO:0000269|PubMed:28256214, ECO:0000269|PubMed:29844171}. |
| Q99666 | RGPD5 | S918 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99865 | SPIN2A | S195 | ochoa | Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A) | May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000250|UniProtKB:Q9BPZ2, ECO:0000269|PubMed:29061846}. |
| Q99986 | VRK1 | S342 | ochoa|psp | Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) | Serine/threonine kinase involved in the regulation of key cellular processes including the cell cycle, nuclear condensation, transcription regulation, and DNA damage response (PubMed:14645249, PubMed:18617507, PubMed:19103756, PubMed:33076429). Controls chromatin organization and remodeling by mediating phosphorylation of histone H3 on 'Thr-4' and histone H2AX (H2aXT4ph) (PubMed:31527692, PubMed:37179361). It also phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Is involved in the regulation of cell cycle progression of neural progenitors, and is required for proper cortical neuronal migration (By similarity). Is involved in neurite elongation and branching in motor neurons, and has an essential role in Cajal bodies assembly, acting through COIL phosphorylation and the control of coilin degradation (PubMed:21920476, PubMed:31090908, PubMed:31527692). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, it is required to induce Golgi fragmentation (PubMed:19103756). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (PubMed:16495336). Phosphorylates TP53BP1 and p53/TP53 on 'Thr-18', preventing the interaction between p53/TP53 and MDM2 (PubMed:10951572, PubMed:31527692). Phosphorylates ATF2 which activates its transcriptional activity (PubMed:15105425). Phosphorylates JUN (PubMed:31527692). {ECO:0000250|UniProtKB:Q80X41, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:21920476, ECO:0000269|PubMed:31090908, ECO:0000269|PubMed:31527692, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:37179361}. |
| Q9BPX3 | NCAPG | S390 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BPZ2 | SPIN2B | S195 | ochoa | Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B) | Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000269|PubMed:12145692, ECO:0000269|PubMed:29061846}. |
| Q9BU76 | MMTAG2 | S161 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BXF6 | RAB11FIP5 | S566 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXW9 | FANCD2 | S1407 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BYT3 | STK33 | S43 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9C0C9 | UBE2O | S407 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0C9 | UBE2O | S839 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0D5 | TANC1 | S270 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H013 | ADAM19 | S756 | ochoa | Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM) | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}. |
| Q9H081 | MIS12 | S180 | ochoa | Protein MIS12 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270, ECO:0000269|PubMed:23891108}. |
| Q9H089 | LSG1 | S57 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H089 | LSG1 | S628 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H4G0 | EPB41L1 | S578 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H582 | ZNF644 | S669 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9HCK8 | CHD8 | S440 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCX4 | TRPC7 | S714 | psp | Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250|UniProtKB:Q9WVC5}. |
| Q9NSI6 | BRWD1 | S1607 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NUL5 | SHFL | S256 | ochoa | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) | Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Also interrupts Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway (PubMed:32150556). Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus (PubMed:26735137, PubMed:27974568, PubMed:30944177, PubMed:32294532). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:30944177, ECO:0000269|PubMed:32150556, ECO:0000269|PubMed:32294532}.; FUNCTION: Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes. {ECO:0000269|PubMed:30682371}. |
| Q9P260 | RELCH | S193 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9UHD8 | SEPTIN9 | S332 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UL01 | DSE | S797 | ochoa | Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2) | Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate. {ECO:0000269|PubMed:16505484, ECO:0000269|PubMed:19004833, ECO:0000269|PubMed:7092807, ECO:0000269|Ref.7}. |
| Q9ULD4 | BRPF3 | S76 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9UPQ0 | LIMCH1 | S621 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ84 | EXO1 | S454 | psp | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9Y210 | TRPC6 | S840 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2S7 | POLDIP2 | S290 | ochoa | Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38) | Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). {ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:26984527}. |
| Q9Y3B2 | EXOSC1 | S98 | ochoa | Exosome complex component CSL4 (Exosome component 1) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8. |
| Q9Y3T9 | NOC2L | S635 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y485 | DMXL1 | S465 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4W2 | LAS1L | S510 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y657 | SPIN1 | S199 | ochoa | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| O95625 | ZBTB11 | S537 | EPSD|PSP | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| Q9BQG0 | MYBBP1A | S1310 | EPSD|PSP | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9Y6A5 | TACC3 | S34 | SIGNOR | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| P55036 | PSMD4 | S115 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| Q9NY33 | DPP3 | S218 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| O75914 | PAK3 | S143 | Sugiyama | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| Q9UPY6 | WASF3 | S155 | Sugiyama | Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3) | Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:21834987}. |
| Q9Y6W5 | WASF2 | S154 | Sugiyama | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| A0AVT1 | UBA6 | S697 | Sugiyama | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| P24666 | ACP1 | S48 | Sugiyama | Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1) | Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2. {ECO:0000269|PubMed:10336608, ECO:0000269|PubMed:9705307}.; FUNCTION: [Isoform 3]: Does not possess phosphatase activity. {ECO:0000269|PubMed:10336608}. |
| O76003 | GLRX3 | Y302 | Sugiyama | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
| Q96PZ0 | PUS7 | S569 | Sugiyama | Pseudouridylate synthase 7 homolog (EC 5.4.99.-) | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}. |
| P27797 | CALR | S189 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P29323 | EPHB2 | S914 | Sugiyama | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P53609 | PGGT1B | S347 | Sugiyama | Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) | Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269|PubMed:8106351}. |
| Q92997 | DVL3 | S263 | GPS6 | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| P49590 | HARS2 | S127 | Sugiyama | Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS) | Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). {ECO:0000269|PubMed:21464306}. |
| P31949 | S100A11 | S35 | Sugiyama | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
| P49959 | MRE11 | S447 | Sugiyama | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| Q15417 | CNN3 | S175 | Sugiyama | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q9H4B4 | PLK3 | S86 | Sugiyama | Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}. |
| Q8NEN9 | PDZD8 | S503 | Sugiyama | PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. |
| P52789 | HK2 | S408 | Sugiyama | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| Q5SSJ5 | HP1BP3 | S323 | Sugiyama | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q8IYP9 | ZDHHC23 | S200 | Sugiyama | Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. {ECO:0000269|PubMed:22399288, ECO:0000305|PubMed:22399288}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 6.734419e-07 | 6.172 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.476319e-06 | 5.606 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.745005e-05 | 4.561 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.327986e-05 | 4.273 |
| R-HSA-75153 | Apoptotic execution phase | 5.850338e-05 | 4.233 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.840999e-04 | 3.735 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.202578e-04 | 3.495 |
| R-HSA-2262752 | Cellular responses to stress | 3.725675e-04 | 3.429 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.945128e-04 | 3.158 |
| R-HSA-1640170 | Cell Cycle | 6.055869e-04 | 3.218 |
| R-HSA-73894 | DNA Repair | 8.250683e-04 | 3.084 |
| R-HSA-2559583 | Cellular Senescence | 8.013869e-04 | 3.096 |
| R-HSA-109581 | Apoptosis | 1.730048e-03 | 2.762 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 2.503423e-03 | 2.601 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.255152e-03 | 2.487 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.646931e-03 | 2.438 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.646931e-03 | 2.438 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.646931e-03 | 2.438 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.646931e-03 | 2.438 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.551952e-03 | 2.593 |
| R-HSA-5358508 | Mismatch Repair | 2.890370e-03 | 2.539 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.354954e-03 | 2.628 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.551952e-03 | 2.593 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.439130e-03 | 2.464 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.275896e-03 | 2.643 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.492041e-03 | 2.603 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.152883e-03 | 2.501 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.629149e-03 | 2.334 |
| R-HSA-9675135 | Diseases of DNA repair | 4.446955e-03 | 2.352 |
| R-HSA-9659379 | Sensory processing of sound | 4.406417e-03 | 2.356 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.048533e-03 | 2.297 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 6.595678e-03 | 2.181 |
| R-HSA-5693538 | Homology Directed Repair | 5.769497e-03 | 2.239 |
| R-HSA-73886 | Chromosome Maintenance | 6.410889e-03 | 2.193 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 6.736866e-03 | 2.172 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.335008e-03 | 2.198 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.374055e-03 | 2.196 |
| R-HSA-5357801 | Programmed Cell Death | 6.542891e-03 | 2.184 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.785385e-03 | 2.168 |
| R-HSA-3295583 | TRP channels | 7.191344e-03 | 2.143 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 7.996503e-03 | 2.097 |
| R-HSA-69481 | G2/M Checkpoints | 8.107056e-03 | 2.091 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 7.996503e-03 | 2.097 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 9.165061e-03 | 2.038 |
| R-HSA-418360 | Platelet calcium homeostasis | 9.165061e-03 | 2.038 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.341561e-03 | 2.030 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.203689e-02 | 1.919 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.362321e-02 | 1.866 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.309511e-02 | 1.883 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.224387e-02 | 1.912 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.224387e-02 | 1.912 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.142546e-02 | 1.942 |
| R-HSA-157579 | Telomere Maintenance | 1.062206e-02 | 1.974 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.277427e-02 | 1.894 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.309511e-02 | 1.883 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.309511e-02 | 1.883 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.245481e-02 | 1.905 |
| R-HSA-69091 | Polymerase switching | 1.644895e-02 | 1.784 |
| R-HSA-69109 | Leading Strand Synthesis | 1.644895e-02 | 1.784 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.616370e-02 | 1.791 |
| R-HSA-68877 | Mitotic Prometaphase | 1.545994e-02 | 1.811 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.397936e-02 | 1.855 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.397936e-02 | 1.855 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.489678e-02 | 1.827 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.644895e-02 | 1.784 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.457132e-02 | 1.837 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.553350e-02 | 1.809 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.553350e-02 | 1.809 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.842389e-02 | 1.735 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.842389e-02 | 1.735 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.784937e-02 | 1.748 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.842389e-02 | 1.735 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.973268e-02 | 1.705 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.392963e-02 | 1.621 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.392963e-02 | 1.621 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.392963e-02 | 1.621 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.392963e-02 | 1.621 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 2.392963e-02 | 1.621 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.392963e-02 | 1.621 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 2.392963e-02 | 1.621 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.375248e-02 | 1.624 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.110431e-02 | 1.676 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.225671e-02 | 1.653 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.265538e-02 | 1.645 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.490690e-02 | 1.604 |
| R-HSA-373752 | Netrin-1 signaling | 2.591631e-02 | 1.586 |
| R-HSA-373760 | L1CAM interactions | 2.176990e-02 | 1.662 |
| R-HSA-68886 | M Phase | 2.599210e-02 | 1.585 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.638576e-02 | 1.579 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.730088e-02 | 1.564 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.918757e-02 | 1.535 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.966923e-02 | 1.528 |
| R-HSA-437239 | Recycling pathway of L1 | 2.987881e-02 | 1.525 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.015924e-02 | 1.521 |
| R-HSA-3928664 | Ephrin signaling | 3.217529e-02 | 1.492 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.217529e-02 | 1.492 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.217529e-02 | 1.492 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.476150e-02 | 1.459 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.530271e-02 | 1.452 |
| R-HSA-912446 | Meiotic recombination | 3.562987e-02 | 1.448 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 3.567993e-02 | 1.448 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 3.567993e-02 | 1.448 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 3.567993e-02 | 1.448 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 3.567993e-02 | 1.448 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.622035e-02 | 1.441 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.297857e-02 | 1.367 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.355938e-02 | 1.361 |
| R-HSA-69186 | Lagging Strand Synthesis | 4.016535e-02 | 1.396 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 4.586312e-02 | 1.339 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 4.016535e-02 | 1.396 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.586312e-02 | 1.339 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.297857e-02 | 1.367 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 4.586312e-02 | 1.339 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 4.297857e-02 | 1.367 |
| R-HSA-4839726 | Chromatin organization | 4.672912e-02 | 1.330 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.695741e-02 | 1.328 |
| R-HSA-70171 | Glycolysis | 4.702463e-02 | 1.328 |
| R-HSA-9918440 | Defective visual phototransduction due to RDH12 loss of function | 4.728950e-02 | 1.325 |
| R-HSA-9675132 | Diseases of cellular response to stress | 4.728950e-02 | 1.325 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 4.728950e-02 | 1.325 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 5.183780e-02 | 1.285 |
| R-HSA-525793 | Myogenesis | 5.807304e-02 | 1.236 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 5.492385e-02 | 1.260 |
| R-HSA-69242 | S Phase | 5.263691e-02 | 1.279 |
| R-HSA-180786 | Extension of Telomeres | 4.870412e-02 | 1.312 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 5.183780e-02 | 1.285 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 5.807304e-02 | 1.236 |
| R-HSA-379724 | tRNA Aminoacylation | 5.048234e-02 | 1.297 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 5.807304e-02 | 1.236 |
| R-HSA-1266695 | Interleukin-7 signaling | 5.492385e-02 | 1.260 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.881688e-02 | 1.311 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.223838e-02 | 1.282 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 5.807304e-02 | 1.236 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.597390e-02 | 1.252 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 5.876000e-02 | 1.231 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 5.876000e-02 | 1.231 |
| R-HSA-8941237 | Invadopodia formation | 5.876000e-02 | 1.231 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 5.876000e-02 | 1.231 |
| R-HSA-8981607 | Intracellular oxygen transport | 5.876000e-02 | 1.231 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 6.128342e-02 | 1.213 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 6.128342e-02 | 1.213 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.260108e-02 | 1.203 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 6.788014e-02 | 1.168 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 8.076416e-02 | 1.093 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 7.418816e-02 | 1.130 |
| R-HSA-69190 | DNA strand elongation | 7.818753e-02 | 1.107 |
| R-HSA-9930044 | Nuclear RNA decay | 8.172617e-02 | 1.088 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.126240e-02 | 1.090 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.181380e-02 | 1.144 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 7.126277e-02 | 1.147 |
| R-HSA-8852135 | Protein ubiquitination | 8.076416e-02 | 1.093 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.026170e-02 | 1.095 |
| R-HSA-68882 | Mitotic Anaphase | 6.882773e-02 | 1.162 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.992564e-02 | 1.155 |
| R-HSA-70326 | Glucose metabolism | 7.615573e-02 | 1.118 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.290938e-02 | 1.137 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 8.129044e-02 | 1.090 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.559484e-02 | 1.183 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.822214e-02 | 1.166 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 8.286315e-02 | 1.082 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.286315e-02 | 1.082 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 9.235362e-02 | 1.035 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.140839e-01 | 0.943 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.140839e-01 | 0.943 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.352966e-01 | 0.869 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.352966e-01 | 0.869 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.457126e-01 | 0.837 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.560039e-01 | 0.807 |
| R-HSA-4839744 | Signaling by APC mutants | 1.560039e-01 | 0.807 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.560039e-01 | 0.807 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.560039e-01 | 0.807 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.560039e-01 | 0.807 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.661717e-01 | 0.779 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.661717e-01 | 0.779 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.661717e-01 | 0.779 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.762177e-01 | 0.754 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.762177e-01 | 0.754 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.762177e-01 | 0.754 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.762177e-01 | 0.754 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.762177e-01 | 0.754 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.762177e-01 | 0.754 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.861433e-01 | 0.730 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 1.861433e-01 | 0.730 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.959499e-01 | 0.708 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.056389e-01 | 0.687 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.056389e-01 | 0.687 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.152118e-01 | 0.667 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 8.894744e-02 | 1.051 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 8.894744e-02 | 1.051 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.246699e-01 | 0.648 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.340146e-01 | 0.631 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.116473e-01 | 0.952 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.523691e-01 | 0.598 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.235049e-01 | 0.908 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.877757e-01 | 0.541 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.963635e-01 | 0.528 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.963635e-01 | 0.528 |
| R-HSA-72187 | mRNA 3'-end processing | 1.649125e-01 | 0.783 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.068902e-01 | 0.971 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.068902e-01 | 0.971 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.296967e-01 | 0.482 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.296967e-01 | 0.482 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.296967e-01 | 0.482 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.127241e-01 | 0.672 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.127241e-01 | 0.672 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.260049e-01 | 0.646 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.571866e-01 | 0.590 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.571866e-01 | 0.590 |
| R-HSA-380287 | Centrosome maturation | 2.661185e-01 | 0.575 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.973474e-01 | 0.527 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.283737e-01 | 0.484 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.215137e-01 | 0.493 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.056389e-01 | 0.687 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.155656e-01 | 0.937 |
| R-HSA-73893 | DNA Damage Bypass | 1.522301e-01 | 0.817 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.195404e-01 | 0.495 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.056389e-01 | 0.687 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.246699e-01 | 0.648 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.116473e-01 | 0.952 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.523691e-01 | 0.598 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.438007e-01 | 0.613 |
| R-HSA-69236 | G1 Phase | 1.315720e-01 | 0.881 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.315720e-01 | 0.881 |
| R-HSA-1500620 | Meiosis | 1.043916e-01 | 0.981 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.661717e-01 | 0.779 |
| R-HSA-9664420 | Killing mechanisms | 2.152118e-01 | 0.667 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.152118e-01 | 0.667 |
| R-HSA-5696400 | Dual Incision in GG-NER | 8.894744e-02 | 1.051 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.438007e-01 | 0.613 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.348928e-01 | 0.629 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.246699e-01 | 0.648 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.884372e-01 | 0.540 |
| R-HSA-4641258 | Degradation of DVL | 1.001148e-01 | 1.000 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.526384e-01 | 0.816 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.482601e-01 | 0.605 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.700609e-01 | 0.769 |
| R-HSA-1483101 | Synthesis of PS | 9.235362e-02 | 1.035 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.661717e-01 | 0.779 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.661717e-01 | 0.779 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.661717e-01 | 0.779 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.056389e-01 | 0.687 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.432472e-01 | 0.614 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.523691e-01 | 0.598 |
| R-HSA-774815 | Nucleosome assembly | 1.356501e-01 | 0.868 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.356501e-01 | 0.868 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.296967e-01 | 0.482 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.039140e-01 | 0.691 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.039140e-01 | 0.691 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.789795e-01 | 0.747 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 1.235049e-01 | 0.908 |
| R-HSA-69239 | Synthesis of DNA | 1.759922e-01 | 0.755 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.315720e-01 | 0.881 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.056389e-01 | 0.687 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.527224e-01 | 0.597 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.260049e-01 | 0.646 |
| R-HSA-418597 | G alpha (z) signalling events | 1.777727e-01 | 0.750 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.415952e-01 | 0.849 |
| R-HSA-72766 | Translation | 3.047762e-01 | 0.516 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.762177e-01 | 0.754 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.691809e-01 | 0.772 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.327790e-01 | 0.478 |
| R-HSA-8953854 | Metabolism of RNA | 2.397208e-01 | 0.620 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.661717e-01 | 0.779 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.116473e-01 | 0.952 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.155656e-01 | 0.937 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.523691e-01 | 0.598 |
| R-HSA-3214847 | HATs acetylate histones | 1.497926e-01 | 0.825 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.062409e-01 | 0.514 |
| R-HSA-68875 | Mitotic Prophase | 2.221063e-01 | 0.653 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.004707e-01 | 0.998 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.048483e-01 | 0.516 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.705847e-01 | 0.568 |
| R-HSA-4086400 | PCP/CE pathway | 2.795147e-01 | 0.554 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.997556e-01 | 0.523 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.777727e-01 | 0.750 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.083141e-01 | 0.681 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.571866e-01 | 0.590 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.084156e-01 | 0.965 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.164193e-01 | 0.934 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.555014e-01 | 0.808 |
| R-HSA-428540 | Activation of RAC1 | 1.661717e-01 | 0.779 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.762177e-01 | 0.754 |
| R-HSA-9857492 | Protein lipoylation | 2.056389e-01 | 0.687 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.056389e-01 | 0.687 |
| R-HSA-163615 | PKA activation | 2.432472e-01 | 0.614 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.649125e-01 | 0.783 |
| R-HSA-9839394 | TGFBR3 expression | 3.132313e-01 | 0.504 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.296967e-01 | 0.482 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.296967e-01 | 0.482 |
| R-HSA-1474165 | Reproduction | 2.605396e-01 | 0.584 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.801724e-01 | 0.553 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.613816e-01 | 0.583 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.068902e-01 | 0.971 |
| R-HSA-8939211 | ESR-mediated signaling | 2.026695e-01 | 0.693 |
| R-HSA-3214842 | HDMs demethylate histones | 3.132313e-01 | 0.504 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.407836e-02 | 1.075 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.864308e-01 | 0.729 |
| R-HSA-397014 | Muscle contraction | 1.524352e-01 | 0.817 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.670351e-01 | 0.573 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.001148e-01 | 1.000 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.795147e-01 | 0.554 |
| R-HSA-422475 | Axon guidance | 8.473774e-02 | 1.072 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.286841e-01 | 0.890 |
| R-HSA-69306 | DNA Replication | 1.549303e-01 | 0.810 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 1.457126e-01 | 0.837 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.560039e-01 | 0.807 |
| R-HSA-2022923 | DS-GAG biosynthesis | 1.661717e-01 | 0.779 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.861433e-01 | 0.730 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.056389e-01 | 0.687 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.152118e-01 | 0.667 |
| R-HSA-9766229 | Degradation of CDH1 | 1.522301e-01 | 0.817 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.583811e-01 | 0.800 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.819807e-01 | 0.740 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.062409e-01 | 0.514 |
| R-HSA-9675108 | Nervous system development | 1.172000e-01 | 0.931 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 9.226063e-02 | 1.035 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.356501e-01 | 0.868 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.356501e-01 | 0.868 |
| R-HSA-114608 | Platelet degranulation | 9.527330e-02 | 1.021 |
| R-HSA-72312 | rRNA processing | 1.921948e-01 | 0.716 |
| R-HSA-9907900 | Proteasome assembly | 1.315720e-01 | 0.881 |
| R-HSA-74160 | Gene expression (Transcription) | 1.215644e-01 | 0.915 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.861433e-01 | 0.730 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.056389e-01 | 0.687 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.048483e-01 | 0.516 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.649125e-01 | 0.783 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.527224e-01 | 0.597 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.155656e-01 | 0.937 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.527224e-01 | 0.597 |
| R-HSA-168255 | Influenza Infection | 2.200105e-01 | 0.658 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.438007e-01 | 0.613 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.200316e-01 | 0.495 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.195030e-01 | 0.496 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.056389e-01 | 0.687 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 2.340146e-01 | 0.631 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.702860e-01 | 0.568 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.790836e-01 | 0.554 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.085055e-01 | 0.965 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.155656e-01 | 0.937 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.973474e-01 | 0.527 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.828523e-01 | 0.548 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.441540e-01 | 0.841 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.941178e-01 | 0.712 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.056389e-01 | 0.687 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.523691e-01 | 0.598 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.864308e-01 | 0.729 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.748252e-01 | 0.561 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.369213e-01 | 0.864 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.995247e-01 | 0.700 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.641896e-01 | 0.785 |
| R-HSA-73884 | Base Excision Repair | 1.197255e-01 | 0.922 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.296967e-01 | 0.482 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.480474e-01 | 0.830 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.457126e-01 | 0.837 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.616522e-01 | 0.582 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.106800e-01 | 0.508 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.049268e-01 | 0.688 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.971835e-01 | 0.705 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.048483e-01 | 0.516 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.127241e-01 | 0.672 |
| R-HSA-917937 | Iron uptake and transport | 2.661185e-01 | 0.575 |
| R-HSA-5688426 | Deubiquitination | 2.418495e-01 | 0.616 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.438007e-01 | 0.613 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.152118e-01 | 0.667 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.613816e-01 | 0.583 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.790836e-01 | 0.554 |
| R-HSA-983712 | Ion channel transport | 1.100406e-01 | 0.958 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.790836e-01 | 0.554 |
| R-HSA-2453864 | Retinoid cycle disease events | 3.132313e-01 | 0.504 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.049268e-01 | 0.688 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.049268e-01 | 0.688 |
| R-HSA-212436 | Generic Transcription Pathway | 1.421085e-01 | 0.847 |
| R-HSA-9675143 | Diseases of the neuronal system | 3.132313e-01 | 0.504 |
| R-HSA-2474795 | Diseases associated with visual transduction | 3.132313e-01 | 0.504 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.864308e-01 | 0.729 |
| R-HSA-72306 | tRNA processing | 1.975043e-01 | 0.704 |
| R-HSA-194138 | Signaling by VEGF | 9.164187e-02 | 1.038 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.877757e-01 | 0.541 |
| R-HSA-418346 | Platelet homeostasis | 1.730192e-01 | 0.762 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.217444e-01 | 0.915 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.438007e-01 | 0.613 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.116473e-01 | 0.952 |
| R-HSA-418990 | Adherens junctions interactions | 1.639777e-01 | 0.785 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.963635e-01 | 0.528 |
| R-HSA-421270 | Cell-cell junction organization | 2.329623e-01 | 0.633 |
| R-HSA-157118 | Signaling by NOTCH | 2.090458e-01 | 0.680 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.482601e-01 | 0.605 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.482040e-01 | 0.829 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 2.260049e-01 | 0.646 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.181733e-01 | 0.927 |
| R-HSA-446728 | Cell junction organization | 2.945063e-01 | 0.531 |
| R-HSA-168268 | Virus Assembly and Release | 2.152118e-01 | 0.667 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.348928e-01 | 0.629 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.616522e-01 | 0.582 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.083141e-01 | 0.681 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.789795e-01 | 0.747 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.410607e-01 | 0.618 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.371762e-01 | 0.472 |
| R-HSA-112310 | Neurotransmitter release cycle | 3.371762e-01 | 0.472 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.377816e-01 | 0.471 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.377816e-01 | 0.471 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.377816e-01 | 0.471 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.377816e-01 | 0.471 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.377816e-01 | 0.471 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.377816e-01 | 0.471 |
| R-HSA-77387 | Insulin receptor recycling | 3.377816e-01 | 0.471 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.377816e-01 | 0.471 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.415648e-01 | 0.467 |
| R-HSA-195721 | Signaling by WNT | 3.417508e-01 | 0.466 |
| R-HSA-5334118 | DNA methylation | 3.457694e-01 | 0.461 |
| R-HSA-72086 | mRNA Capping | 3.457694e-01 | 0.461 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.457694e-01 | 0.461 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.457694e-01 | 0.461 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.491416e-01 | 0.457 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.503144e-01 | 0.456 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.536613e-01 | 0.451 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.536613e-01 | 0.451 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.546747e-01 | 0.450 |
| R-HSA-6798695 | Neutrophil degranulation | 3.592197e-01 | 0.445 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.614586e-01 | 0.442 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.614586e-01 | 0.442 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.614586e-01 | 0.442 |
| R-HSA-182971 | EGFR downregulation | 3.614586e-01 | 0.442 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.614586e-01 | 0.442 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.614586e-01 | 0.442 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.676923e-01 | 0.435 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.691622e-01 | 0.433 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.691622e-01 | 0.433 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.691622e-01 | 0.433 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.691622e-01 | 0.433 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.720093e-01 | 0.429 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.767734e-01 | 0.424 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.767734e-01 | 0.424 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.767734e-01 | 0.424 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.767734e-01 | 0.424 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.767734e-01 | 0.424 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.767734e-01 | 0.424 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.786507e-01 | 0.422 |
| R-HSA-449147 | Signaling by Interleukins | 3.821989e-01 | 0.418 |
| R-HSA-390522 | Striated Muscle Contraction | 3.842932e-01 | 0.415 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.842932e-01 | 0.415 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.842932e-01 | 0.415 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.842932e-01 | 0.415 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.842932e-01 | 0.415 |
| R-HSA-1500931 | Cell-Cell communication | 3.847383e-01 | 0.415 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.891566e-01 | 0.410 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.917227e-01 | 0.407 |
| R-HSA-5205647 | Mitophagy | 3.917227e-01 | 0.407 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.917227e-01 | 0.407 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.917227e-01 | 0.407 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.917227e-01 | 0.407 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.917227e-01 | 0.407 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.917227e-01 | 0.407 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.990631e-01 | 0.399 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.990631e-01 | 0.399 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.990631e-01 | 0.399 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.990631e-01 | 0.399 |
| R-HSA-169911 | Regulation of Apoptosis | 3.990631e-01 | 0.399 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 3.990631e-01 | 0.399 |
| R-HSA-381042 | PERK regulates gene expression | 3.990631e-01 | 0.399 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.990631e-01 | 0.399 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.014539e-01 | 0.396 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.063153e-01 | 0.391 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.063153e-01 | 0.391 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.063153e-01 | 0.391 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.063153e-01 | 0.391 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 4.063153e-01 | 0.391 |
| R-HSA-111933 | Calmodulin induced events | 4.063153e-01 | 0.391 |
| R-HSA-111997 | CaM pathway | 4.063153e-01 | 0.391 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.063153e-01 | 0.391 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.134804e-01 | 0.384 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.134804e-01 | 0.384 |
| R-HSA-4641257 | Degradation of AXIN | 4.134804e-01 | 0.384 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.134804e-01 | 0.384 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.134804e-01 | 0.384 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.134804e-01 | 0.384 |
| R-HSA-196757 | Metabolism of folate and pterines | 4.134804e-01 | 0.384 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.143210e-01 | 0.383 |
| R-HSA-73927 | Depurination | 4.205595e-01 | 0.376 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.205595e-01 | 0.376 |
| R-HSA-199991 | Membrane Trafficking | 4.218700e-01 | 0.375 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.228072e-01 | 0.374 |
| R-HSA-211000 | Gene Silencing by RNA | 4.228072e-01 | 0.374 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.269477e-01 | 0.370 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.275536e-01 | 0.369 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.275536e-01 | 0.369 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.275536e-01 | 0.369 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.275536e-01 | 0.369 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.275536e-01 | 0.369 |
| R-HSA-69541 | Stabilization of p53 | 4.275536e-01 | 0.369 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.275536e-01 | 0.369 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.310727e-01 | 0.365 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.344637e-01 | 0.362 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.344637e-01 | 0.362 |
| R-HSA-167169 | HIV Transcription Elongation | 4.344637e-01 | 0.362 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.344637e-01 | 0.362 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.344637e-01 | 0.362 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.344637e-01 | 0.362 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.344637e-01 | 0.362 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.344637e-01 | 0.362 |
| R-HSA-202433 | Generation of second messenger molecules | 4.344637e-01 | 0.362 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 4.344637e-01 | 0.362 |
| R-HSA-202403 | TCR signaling | 4.351821e-01 | 0.361 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.412908e-01 | 0.355 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.412908e-01 | 0.355 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.412908e-01 | 0.355 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.412908e-01 | 0.355 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.412908e-01 | 0.355 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.412908e-01 | 0.355 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.412908e-01 | 0.355 |
| R-HSA-9607240 | FLT3 Signaling | 4.412908e-01 | 0.355 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.480359e-01 | 0.349 |
| R-HSA-167161 | HIV Transcription Initiation | 4.480359e-01 | 0.349 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.480359e-01 | 0.349 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.480359e-01 | 0.349 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.480359e-01 | 0.349 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 4.480359e-01 | 0.349 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.480359e-01 | 0.349 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.480359e-01 | 0.349 |
| R-HSA-69275 | G2/M Transition | 4.524738e-01 | 0.344 |
| R-HSA-991365 | Activation of GABAB receptors | 4.547000e-01 | 0.342 |
| R-HSA-977444 | GABA B receptor activation | 4.547000e-01 | 0.342 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.547000e-01 | 0.342 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.547000e-01 | 0.342 |
| R-HSA-73928 | Depyrimidination | 4.547000e-01 | 0.342 |
| R-HSA-111996 | Ca-dependent events | 4.547000e-01 | 0.342 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.587372e-01 | 0.338 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.594967e-01 | 0.338 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.612840e-01 | 0.336 |
| R-HSA-9710421 | Defective pyroptosis | 4.612840e-01 | 0.336 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.612840e-01 | 0.336 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.677890e-01 | 0.330 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.677890e-01 | 0.330 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.742158e-01 | 0.324 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.742158e-01 | 0.324 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.742158e-01 | 0.324 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.742158e-01 | 0.324 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.742158e-01 | 0.324 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.742158e-01 | 0.324 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.742158e-01 | 0.324 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.742158e-01 | 0.324 |
| R-HSA-9824272 | Somitogenesis | 4.742158e-01 | 0.324 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 4.742158e-01 | 0.324 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.742158e-01 | 0.324 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.753674e-01 | 0.323 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.792912e-01 | 0.319 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.805654e-01 | 0.318 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.805654e-01 | 0.318 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.805654e-01 | 0.318 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.805654e-01 | 0.318 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.805654e-01 | 0.318 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.805654e-01 | 0.318 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.868387e-01 | 0.313 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.868387e-01 | 0.313 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.868387e-01 | 0.313 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.904171e-01 | 0.309 |
| R-HSA-9634597 | GPER1 signaling | 4.930366e-01 | 0.307 |
| R-HSA-70263 | Gluconeogenesis | 4.930366e-01 | 0.307 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.930366e-01 | 0.307 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.948060e-01 | 0.306 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.955856e-01 | 0.305 |
| R-HSA-9658195 | Leishmania infection | 4.955856e-01 | 0.305 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.981617e-01 | 0.303 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.986390e-01 | 0.302 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.991600e-01 | 0.302 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.991600e-01 | 0.302 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.991600e-01 | 0.302 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 5.052098e-01 | 0.297 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 5.052098e-01 | 0.297 |
| R-HSA-69206 | G1/S Transition | 5.062494e-01 | 0.296 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.111870e-01 | 0.291 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.111870e-01 | 0.291 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.111870e-01 | 0.291 |
| R-HSA-168256 | Immune System | 5.160510e-01 | 0.287 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.170923e-01 | 0.286 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.170923e-01 | 0.286 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.170923e-01 | 0.286 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.170923e-01 | 0.286 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.170923e-01 | 0.286 |
| R-HSA-1266738 | Developmental Biology | 5.178942e-01 | 0.286 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.229266e-01 | 0.282 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.229266e-01 | 0.282 |
| R-HSA-1221632 | Meiotic synapsis | 5.229266e-01 | 0.282 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.229266e-01 | 0.282 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.229266e-01 | 0.282 |
| R-HSA-8956320 | Nucleotide biosynthesis | 5.229266e-01 | 0.282 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.229266e-01 | 0.282 |
| R-HSA-162582 | Signal Transduction | 5.232000e-01 | 0.281 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.286908e-01 | 0.277 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.286908e-01 | 0.277 |
| R-HSA-1280218 | Adaptive Immune System | 5.316772e-01 | 0.274 |
| R-HSA-5576891 | Cardiac conduction | 5.322907e-01 | 0.274 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.343857e-01 | 0.272 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.343857e-01 | 0.272 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 5.343857e-01 | 0.272 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.343857e-01 | 0.272 |
| R-HSA-9909396 | Circadian clock | 5.359341e-01 | 0.271 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.400121e-01 | 0.268 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.400121e-01 | 0.268 |
| R-HSA-177929 | Signaling by EGFR | 5.400121e-01 | 0.268 |
| R-HSA-5578775 | Ion homeostasis | 5.400121e-01 | 0.268 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.400121e-01 | 0.268 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.424346e-01 | 0.266 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.503507e-01 | 0.259 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.510628e-01 | 0.259 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.510628e-01 | 0.259 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.538592e-01 | 0.257 |
| R-HSA-191859 | snRNP Assembly | 5.564887e-01 | 0.255 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.564887e-01 | 0.255 |
| R-HSA-9033241 | Peroxisomal protein import | 5.564887e-01 | 0.255 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.564887e-01 | 0.255 |
| R-HSA-8951664 | Neddylation | 5.598755e-01 | 0.252 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.608918e-01 | 0.251 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.608918e-01 | 0.251 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.618494e-01 | 0.250 |
| R-HSA-977443 | GABA receptor activation | 5.618494e-01 | 0.250 |
| R-HSA-351202 | Metabolism of polyamines | 5.618494e-01 | 0.250 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.618494e-01 | 0.250 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.671456e-01 | 0.246 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.671456e-01 | 0.246 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.671456e-01 | 0.246 |
| R-HSA-112043 | PLC beta mediated events | 5.671456e-01 | 0.246 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.678455e-01 | 0.246 |
| R-HSA-9664407 | Parasite infection | 5.678455e-01 | 0.246 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.678455e-01 | 0.246 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.723781e-01 | 0.242 |
| R-HSA-1268020 | Mitochondrial protein import | 5.723781e-01 | 0.242 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.723781e-01 | 0.242 |
| R-HSA-162906 | HIV Infection | 5.765254e-01 | 0.239 |
| R-HSA-6799198 | Complex I biogenesis | 5.775477e-01 | 0.238 |
| R-HSA-373755 | Semaphorin interactions | 5.775477e-01 | 0.238 |
| R-HSA-8848021 | Signaling by PTK6 | 5.775477e-01 | 0.238 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.775477e-01 | 0.238 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.781272e-01 | 0.238 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.826551e-01 | 0.235 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.877010e-01 | 0.231 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.877010e-01 | 0.231 |
| R-HSA-2187338 | Visual phototransduction | 5.948654e-01 | 0.226 |
| R-HSA-112040 | G-protein mediated events | 5.976116e-01 | 0.224 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.982753e-01 | 0.223 |
| R-HSA-167172 | Transcription of the HIV genome | 6.024776e-01 | 0.220 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.111050e-01 | 0.214 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.120348e-01 | 0.213 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.120348e-01 | 0.213 |
| R-HSA-9609507 | Protein localization | 6.142931e-01 | 0.212 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.167272e-01 | 0.210 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.167272e-01 | 0.210 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.167272e-01 | 0.210 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.167272e-01 | 0.210 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.174613e-01 | 0.209 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.213633e-01 | 0.207 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 6.213633e-01 | 0.207 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.240649e-01 | 0.205 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.259435e-01 | 0.203 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.259435e-01 | 0.203 |
| R-HSA-162587 | HIV Life Cycle | 6.268466e-01 | 0.203 |
| R-HSA-9711097 | Cellular response to starvation | 6.299353e-01 | 0.201 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.304686e-01 | 0.200 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 6.304686e-01 | 0.200 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.304686e-01 | 0.200 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.349392e-01 | 0.197 |
| R-HSA-5689603 | UCH proteinases | 6.393561e-01 | 0.194 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.404539e-01 | 0.194 |
| R-HSA-109582 | Hemostasis | 6.434409e-01 | 0.191 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.437197e-01 | 0.191 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.480308e-01 | 0.188 |
| R-HSA-5619084 | ABC transporter disorders | 6.480308e-01 | 0.188 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.564980e-01 | 0.183 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.564980e-01 | 0.183 |
| R-HSA-6806834 | Signaling by MET | 6.564980e-01 | 0.183 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.606553e-01 | 0.180 |
| R-HSA-977225 | Amyloid fiber formation | 6.606553e-01 | 0.180 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.678527e-01 | 0.175 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.688203e-01 | 0.175 |
| R-HSA-416476 | G alpha (q) signalling events | 6.701736e-01 | 0.174 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.711119e-01 | 0.173 |
| R-HSA-168249 | Innate Immune System | 6.733025e-01 | 0.172 |
| R-HSA-382551 | Transport of small molecules | 6.736936e-01 | 0.172 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.767898e-01 | 0.170 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.859574e-01 | 0.164 |
| R-HSA-70268 | Pyruvate metabolism | 6.883877e-01 | 0.162 |
| R-HSA-156902 | Peptide chain elongation | 6.921609e-01 | 0.160 |
| R-HSA-9663891 | Selective autophagy | 6.921609e-01 | 0.160 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.921609e-01 | 0.160 |
| R-HSA-202424 | Downstream TCR signaling | 6.995714e-01 | 0.155 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.032099e-01 | 0.153 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.068045e-01 | 0.151 |
| R-HSA-112316 | Neuronal System | 7.083783e-01 | 0.150 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.103558e-01 | 0.149 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.103558e-01 | 0.149 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.173306e-01 | 0.144 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.207550e-01 | 0.142 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 7.207550e-01 | 0.142 |
| R-HSA-5617833 | Cilium Assembly | 7.209962e-01 | 0.142 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.241382e-01 | 0.140 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.241382e-01 | 0.140 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.258603e-01 | 0.139 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.274806e-01 | 0.138 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.274806e-01 | 0.138 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.340449e-01 | 0.134 |
| R-HSA-190236 | Signaling by FGFR | 7.340449e-01 | 0.134 |
| R-HSA-9609690 | HCMV Early Events | 7.353745e-01 | 0.133 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.363103e-01 | 0.133 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.372679e-01 | 0.132 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.372679e-01 | 0.132 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.404520e-01 | 0.131 |
| R-HSA-597592 | Post-translational protein modification | 7.417537e-01 | 0.130 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.435977e-01 | 0.129 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.435977e-01 | 0.129 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.467055e-01 | 0.127 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.467055e-01 | 0.127 |
| R-HSA-192823 | Viral mRNA Translation | 7.497758e-01 | 0.125 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.497758e-01 | 0.125 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.528090e-01 | 0.123 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.528090e-01 | 0.123 |
| R-HSA-111885 | Opioid Signalling | 7.528090e-01 | 0.123 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.558057e-01 | 0.122 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.558057e-01 | 0.122 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.616911e-01 | 0.118 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.674353e-01 | 0.115 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.674353e-01 | 0.115 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.727377e-01 | 0.112 |
| R-HSA-6803157 | Antimicrobial peptides | 7.757944e-01 | 0.110 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.785138e-01 | 0.109 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.785138e-01 | 0.109 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.785138e-01 | 0.109 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.792258e-01 | 0.108 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.864766e-01 | 0.104 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.941546e-01 | 0.100 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.941546e-01 | 0.100 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.036352e-01 | 0.095 |
| R-HSA-3371556 | Cellular response to heat stress | 8.063455e-01 | 0.093 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.110183e-01 | 0.091 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.110183e-01 | 0.091 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.110183e-01 | 0.091 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.133125e-01 | 0.090 |
| R-HSA-15869 | Metabolism of nucleotides | 8.176471e-01 | 0.087 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.178180e-01 | 0.087 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.178180e-01 | 0.087 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.178180e-01 | 0.087 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.200300e-01 | 0.086 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.243742e-01 | 0.084 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.286140e-01 | 0.082 |
| R-HSA-9717189 | Sensory perception of taste | 8.327521e-01 | 0.079 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.354578e-01 | 0.078 |
| R-HSA-9609646 | HCMV Infection | 8.400364e-01 | 0.076 |
| R-HSA-163685 | Integration of energy metabolism | 8.445791e-01 | 0.073 |
| R-HSA-5368287 | Mitochondrial translation | 8.483335e-01 | 0.071 |
| R-HSA-6807070 | PTEN Regulation | 8.501767e-01 | 0.070 |
| R-HSA-1632852 | Macroautophagy | 8.537966e-01 | 0.069 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.573294e-01 | 0.067 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.590639e-01 | 0.066 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.607773e-01 | 0.065 |
| R-HSA-166520 | Signaling by NTRKs | 8.674264e-01 | 0.062 |
| R-HSA-9758941 | Gastrulation | 8.690387e-01 | 0.061 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.706315e-01 | 0.060 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.737595e-01 | 0.059 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.768122e-01 | 0.057 |
| R-HSA-73887 | Death Receptor Signaling | 8.768122e-01 | 0.057 |
| R-HSA-9612973 | Autophagy | 8.797915e-01 | 0.056 |
| R-HSA-9610379 | HCMV Late Events | 8.812541e-01 | 0.055 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.826991e-01 | 0.054 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.855367e-01 | 0.053 |
| R-HSA-5619102 | SLC transporter disorders | 8.949411e-01 | 0.048 |
| R-HSA-418555 | G alpha (s) signalling events | 9.011839e-01 | 0.045 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.035764e-01 | 0.044 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.035764e-01 | 0.044 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.059113e-01 | 0.043 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.059113e-01 | 0.043 |
| R-HSA-611105 | Respiratory electron transport | 9.093086e-01 | 0.041 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.188545e-01 | 0.037 |
| R-HSA-392499 | Metabolism of proteins | 9.208595e-01 | 0.036 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.245490e-01 | 0.034 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.254693e-01 | 0.034 |
| R-HSA-428157 | Sphingolipid metabolism | 9.316057e-01 | 0.031 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.332647e-01 | 0.030 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.332647e-01 | 0.030 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.342361e-01 | 0.030 |
| R-HSA-72172 | mRNA Splicing | 9.348838e-01 | 0.029 |
| R-HSA-6805567 | Keratinization | 9.364637e-01 | 0.029 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.380990e-01 | 0.028 |
| R-HSA-1643685 | Disease | 9.384351e-01 | 0.028 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.393383e-01 | 0.027 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.479127e-01 | 0.023 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.526342e-01 | 0.021 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.526947e-01 | 0.021 |
| R-HSA-388396 | GPCR downstream signalling | 9.661033e-01 | 0.015 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.771366e-01 | 0.010 |
| R-HSA-1483257 | Phospholipid metabolism | 9.787693e-01 | 0.009 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.790300e-01 | 0.009 |
| R-HSA-372790 | Signaling by GPCR | 9.829535e-01 | 0.007 |
| R-HSA-1474244 | Extracellular matrix organization | 9.863969e-01 | 0.006 |
| R-HSA-9709957 | Sensory Perception | 9.871179e-01 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 9.874010e-01 | 0.006 |
| R-HSA-5663205 | Infectious disease | 9.889025e-01 | 0.005 |
| R-HSA-913531 | Interferon Signaling | 9.929496e-01 | 0.003 |
| R-HSA-9679506 | SARS-CoV Infections | 9.932259e-01 | 0.003 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.935369e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.947682e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.947682e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.999990e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.883 | 0.168 | 2 | 0.903 |
CLK3 |
0.880 | 0.285 | 1 | 0.820 |
PIM3 |
0.872 | 0.171 | -3 | 0.893 |
PRPK |
0.869 | -0.056 | -1 | 0.877 |
MOS |
0.869 | 0.084 | 1 | 0.798 |
CDKL1 |
0.869 | 0.176 | -3 | 0.878 |
ATR |
0.867 | 0.094 | 1 | 0.806 |
DSTYK |
0.867 | 0.039 | 2 | 0.894 |
CAMK1B |
0.866 | 0.075 | -3 | 0.942 |
CDKL5 |
0.866 | 0.218 | -3 | 0.867 |
NDR2 |
0.866 | 0.090 | -3 | 0.893 |
CDC7 |
0.865 | -0.046 | 1 | 0.761 |
ERK5 |
0.865 | 0.151 | 1 | 0.828 |
RAF1 |
0.864 | -0.045 | 1 | 0.764 |
IKKB |
0.864 | -0.056 | -2 | 0.737 |
MTOR |
0.864 | -0.068 | 1 | 0.745 |
NLK |
0.863 | 0.067 | 1 | 0.808 |
CAMK2G |
0.862 | -0.017 | 2 | 0.859 |
PIM1 |
0.862 | 0.191 | -3 | 0.857 |
BMPR2 |
0.862 | -0.096 | -2 | 0.890 |
KIS |
0.862 | 0.124 | 1 | 0.716 |
TBK1 |
0.862 | -0.067 | 1 | 0.678 |
SRPK1 |
0.861 | 0.162 | -3 | 0.823 |
GCN2 |
0.861 | -0.138 | 2 | 0.818 |
ICK |
0.861 | 0.202 | -3 | 0.905 |
PRKD1 |
0.860 | 0.115 | -3 | 0.876 |
PDHK4 |
0.860 | -0.265 | 1 | 0.790 |
NUAK2 |
0.860 | 0.092 | -3 | 0.920 |
PKN3 |
0.859 | 0.043 | -3 | 0.903 |
GRK1 |
0.859 | 0.110 | -2 | 0.807 |
WNK1 |
0.858 | 0.037 | -2 | 0.862 |
HIPK4 |
0.858 | 0.132 | 1 | 0.771 |
SKMLCK |
0.858 | 0.087 | -2 | 0.845 |
ULK2 |
0.857 | -0.127 | 2 | 0.800 |
CAMLCK |
0.857 | 0.046 | -2 | 0.832 |
RSK2 |
0.856 | 0.111 | -3 | 0.845 |
RIPK3 |
0.856 | -0.024 | 3 | 0.715 |
IKKE |
0.856 | -0.117 | 1 | 0.672 |
NIK |
0.856 | -0.019 | -3 | 0.950 |
PDHK1 |
0.855 | -0.201 | 1 | 0.789 |
DYRK2 |
0.855 | 0.170 | 1 | 0.717 |
NDR1 |
0.855 | 0.034 | -3 | 0.898 |
CDK8 |
0.855 | 0.122 | 1 | 0.697 |
ATM |
0.854 | 0.078 | 1 | 0.745 |
PRKD2 |
0.854 | 0.114 | -3 | 0.837 |
TGFBR2 |
0.854 | -0.032 | -2 | 0.819 |
CAMK2D |
0.854 | 0.048 | -3 | 0.915 |
MLK1 |
0.854 | -0.077 | 2 | 0.806 |
NEK6 |
0.854 | -0.057 | -2 | 0.860 |
GRK5 |
0.853 | -0.130 | -3 | 0.917 |
SRPK2 |
0.853 | 0.147 | -3 | 0.755 |
P90RSK |
0.853 | 0.085 | -3 | 0.846 |
DAPK2 |
0.853 | 0.018 | -3 | 0.943 |
MAPKAPK3 |
0.853 | 0.071 | -3 | 0.842 |
NEK7 |
0.853 | -0.134 | -3 | 0.899 |
AMPKA1 |
0.853 | 0.047 | -3 | 0.922 |
CAMK2B |
0.852 | 0.120 | 2 | 0.833 |
GRK6 |
0.852 | -0.012 | 1 | 0.758 |
MST4 |
0.852 | 0.004 | 2 | 0.813 |
HUNK |
0.852 | -0.093 | 2 | 0.852 |
MAPKAPK2 |
0.852 | 0.115 | -3 | 0.791 |
IKKA |
0.852 | -0.009 | -2 | 0.744 |
CHAK2 |
0.852 | -0.044 | -1 | 0.827 |
TSSK2 |
0.851 | 0.050 | -5 | 0.845 |
P70S6KB |
0.851 | 0.072 | -3 | 0.880 |
PKN2 |
0.851 | 0.010 | -3 | 0.918 |
SRPK3 |
0.850 | 0.123 | -3 | 0.807 |
FAM20C |
0.850 | 0.087 | 2 | 0.634 |
BMPR1B |
0.850 | 0.108 | 1 | 0.711 |
PKCD |
0.850 | 0.052 | 2 | 0.784 |
GRK4 |
0.850 | -0.055 | -2 | 0.848 |
LATS2 |
0.850 | 0.028 | -5 | 0.738 |
TGFBR1 |
0.850 | 0.085 | -2 | 0.831 |
MARK4 |
0.849 | -0.042 | 4 | 0.815 |
CDK19 |
0.849 | 0.123 | 1 | 0.666 |
ALK4 |
0.849 | 0.040 | -2 | 0.850 |
BCKDK |
0.848 | -0.134 | -1 | 0.842 |
CLK2 |
0.848 | 0.223 | -3 | 0.823 |
TSSK1 |
0.848 | 0.064 | -3 | 0.931 |
RSK3 |
0.848 | 0.056 | -3 | 0.838 |
AMPKA2 |
0.848 | 0.059 | -3 | 0.892 |
JNK2 |
0.847 | 0.161 | 1 | 0.638 |
JNK3 |
0.847 | 0.138 | 1 | 0.672 |
CAMK2A |
0.847 | 0.098 | 2 | 0.851 |
CLK1 |
0.847 | 0.158 | -3 | 0.836 |
CLK4 |
0.847 | 0.135 | -3 | 0.856 |
WNK3 |
0.847 | -0.191 | 1 | 0.753 |
CDK1 |
0.846 | 0.128 | 1 | 0.648 |
ULK1 |
0.846 | -0.183 | -3 | 0.877 |
CDK5 |
0.846 | 0.133 | 1 | 0.707 |
GRK7 |
0.846 | 0.092 | 1 | 0.697 |
PKACG |
0.845 | 0.024 | -2 | 0.724 |
P38A |
0.845 | 0.165 | 1 | 0.730 |
MASTL |
0.845 | -0.254 | -2 | 0.809 |
DLK |
0.845 | -0.153 | 1 | 0.770 |
P38B |
0.845 | 0.177 | 1 | 0.677 |
IRE1 |
0.845 | -0.052 | 1 | 0.746 |
RIPK1 |
0.844 | -0.161 | 1 | 0.752 |
ANKRD3 |
0.843 | -0.152 | 1 | 0.802 |
NEK9 |
0.843 | -0.166 | 2 | 0.826 |
CAMK4 |
0.843 | -0.044 | -3 | 0.908 |
PLK1 |
0.842 | -0.056 | -2 | 0.827 |
RSK4 |
0.842 | 0.112 | -3 | 0.811 |
DNAPK |
0.842 | 0.093 | 1 | 0.685 |
PAK1 |
0.842 | 0.011 | -2 | 0.767 |
TTBK2 |
0.842 | -0.166 | 2 | 0.716 |
LATS1 |
0.842 | 0.049 | -3 | 0.894 |
CDK7 |
0.842 | 0.069 | 1 | 0.691 |
PRKD3 |
0.841 | 0.063 | -3 | 0.830 |
NUAK1 |
0.841 | 0.028 | -3 | 0.872 |
NIM1 |
0.841 | -0.073 | 3 | 0.750 |
DYRK4 |
0.841 | 0.169 | 1 | 0.652 |
MLK2 |
0.841 | -0.122 | 2 | 0.811 |
ALK2 |
0.841 | 0.054 | -2 | 0.832 |
P38G |
0.841 | 0.131 | 1 | 0.577 |
IRE2 |
0.840 | -0.027 | 2 | 0.765 |
PKR |
0.840 | -0.030 | 1 | 0.789 |
MSK2 |
0.840 | 0.014 | -3 | 0.818 |
ERK1 |
0.840 | 0.129 | 1 | 0.663 |
ACVR2A |
0.840 | 0.005 | -2 | 0.808 |
DYRK1A |
0.840 | 0.159 | 1 | 0.734 |
VRK2 |
0.840 | -0.098 | 1 | 0.835 |
HIPK2 |
0.840 | 0.162 | 1 | 0.635 |
AURC |
0.840 | 0.034 | -2 | 0.636 |
MELK |
0.840 | 0.016 | -3 | 0.882 |
HIPK1 |
0.840 | 0.146 | 1 | 0.736 |
MYLK4 |
0.839 | 0.035 | -2 | 0.741 |
MLK3 |
0.839 | -0.060 | 2 | 0.729 |
ACVR2B |
0.839 | 0.004 | -2 | 0.819 |
CDK18 |
0.839 | 0.110 | 1 | 0.637 |
PAK3 |
0.839 | -0.038 | -2 | 0.756 |
MNK2 |
0.838 | 0.015 | -2 | 0.771 |
MEK1 |
0.838 | -0.162 | 2 | 0.858 |
CDK13 |
0.838 | 0.054 | 1 | 0.666 |
PKCB |
0.837 | 0.008 | 2 | 0.723 |
PIM2 |
0.837 | 0.126 | -3 | 0.833 |
PKCG |
0.837 | -0.021 | 2 | 0.734 |
PKCA |
0.837 | 0.002 | 2 | 0.712 |
MSK1 |
0.837 | 0.054 | -3 | 0.821 |
CDK2 |
0.836 | 0.047 | 1 | 0.715 |
MLK4 |
0.836 | -0.066 | 2 | 0.714 |
CDK3 |
0.835 | 0.136 | 1 | 0.602 |
PLK3 |
0.835 | -0.067 | 2 | 0.825 |
PKACB |
0.835 | 0.082 | -2 | 0.650 |
SMG1 |
0.835 | -0.034 | 1 | 0.769 |
ERK2 |
0.835 | 0.069 | 1 | 0.688 |
PKCZ |
0.834 | -0.031 | 2 | 0.771 |
AURB |
0.834 | 0.014 | -2 | 0.634 |
PKG2 |
0.834 | 0.049 | -2 | 0.652 |
SGK3 |
0.834 | 0.069 | -3 | 0.838 |
P38D |
0.834 | 0.151 | 1 | 0.614 |
PKCH |
0.834 | -0.029 | 2 | 0.720 |
CAMK1G |
0.834 | 0.020 | -3 | 0.859 |
PRKX |
0.834 | 0.122 | -3 | 0.758 |
AKT2 |
0.834 | 0.086 | -3 | 0.779 |
PAK6 |
0.834 | 0.039 | -2 | 0.659 |
PAK2 |
0.833 | -0.049 | -2 | 0.748 |
QSK |
0.833 | -0.035 | 4 | 0.789 |
DYRK3 |
0.833 | 0.134 | 1 | 0.735 |
CHAK1 |
0.833 | -0.143 | 2 | 0.766 |
BMPR1A |
0.833 | 0.064 | 1 | 0.690 |
CHK1 |
0.833 | 0.004 | -3 | 0.870 |
QIK |
0.833 | -0.127 | -3 | 0.923 |
CDK17 |
0.833 | 0.084 | 1 | 0.582 |
YSK4 |
0.833 | -0.174 | 1 | 0.706 |
GRK2 |
0.833 | -0.065 | -2 | 0.746 |
TLK2 |
0.833 | -0.076 | 1 | 0.733 |
PHKG1 |
0.832 | -0.058 | -3 | 0.899 |
SIK |
0.832 | -0.011 | -3 | 0.853 |
MNK1 |
0.832 | 0.003 | -2 | 0.785 |
AURA |
0.832 | 0.007 | -2 | 0.616 |
HIPK3 |
0.832 | 0.105 | 1 | 0.718 |
PRP4 |
0.831 | 0.050 | -3 | 0.785 |
GAK |
0.831 | 0.186 | 1 | 0.827 |
CK1E |
0.831 | 0.046 | -3 | 0.630 |
DCAMKL1 |
0.831 | 0.044 | -3 | 0.858 |
DYRK1B |
0.831 | 0.114 | 1 | 0.668 |
BRAF |
0.831 | -0.056 | -4 | 0.799 |
BRSK1 |
0.831 | -0.050 | -3 | 0.870 |
MPSK1 |
0.830 | 0.148 | 1 | 0.769 |
TLK1 |
0.830 | -0.071 | -2 | 0.850 |
CDK12 |
0.830 | 0.049 | 1 | 0.640 |
NEK2 |
0.830 | -0.159 | 2 | 0.794 |
BRSK2 |
0.829 | -0.080 | -3 | 0.896 |
SMMLCK |
0.829 | 0.019 | -3 | 0.905 |
CDK9 |
0.829 | 0.025 | 1 | 0.675 |
MEKK3 |
0.829 | -0.141 | 1 | 0.739 |
MAPKAPK5 |
0.829 | -0.064 | -3 | 0.804 |
CDK14 |
0.828 | 0.091 | 1 | 0.671 |
HRI |
0.828 | -0.170 | -2 | 0.849 |
MARK2 |
0.828 | -0.068 | 4 | 0.707 |
MARK3 |
0.828 | -0.054 | 4 | 0.746 |
PERK |
0.828 | -0.139 | -2 | 0.836 |
PASK |
0.828 | 0.030 | -3 | 0.912 |
SNRK |
0.827 | -0.165 | 2 | 0.709 |
DRAK1 |
0.827 | -0.113 | 1 | 0.670 |
WNK4 |
0.826 | -0.094 | -2 | 0.847 |
MEKK2 |
0.825 | -0.109 | 2 | 0.809 |
MAK |
0.825 | 0.261 | -2 | 0.811 |
IRAK4 |
0.825 | -0.085 | 1 | 0.761 |
NEK5 |
0.825 | -0.109 | 1 | 0.783 |
CDK10 |
0.825 | 0.107 | 1 | 0.658 |
PINK1 |
0.825 | -0.164 | 1 | 0.796 |
MEK5 |
0.825 | -0.277 | 2 | 0.831 |
CDK16 |
0.825 | 0.103 | 1 | 0.600 |
ZAK |
0.824 | -0.149 | 1 | 0.738 |
PLK4 |
0.824 | -0.154 | 2 | 0.675 |
DCAMKL2 |
0.824 | -0.009 | -3 | 0.888 |
CAMK1D |
0.823 | 0.064 | -3 | 0.773 |
MST3 |
0.823 | -0.045 | 2 | 0.818 |
MEKK1 |
0.823 | -0.191 | 1 | 0.767 |
MARK1 |
0.823 | -0.097 | 4 | 0.775 |
PKACA |
0.823 | 0.067 | -2 | 0.596 |
TAO3 |
0.822 | -0.054 | 1 | 0.731 |
SSTK |
0.822 | -0.033 | 4 | 0.796 |
AKT1 |
0.821 | 0.067 | -3 | 0.793 |
JNK1 |
0.821 | 0.077 | 1 | 0.625 |
CK2A2 |
0.821 | 0.092 | 1 | 0.629 |
CK1D |
0.821 | 0.032 | -3 | 0.582 |
GSK3A |
0.821 | 0.033 | 4 | 0.454 |
P70S6K |
0.820 | 0.023 | -3 | 0.799 |
PKCT |
0.820 | -0.040 | 2 | 0.724 |
GRK3 |
0.819 | -0.050 | -2 | 0.708 |
EEF2K |
0.819 | 0.019 | 3 | 0.815 |
MOK |
0.819 | 0.197 | 1 | 0.757 |
PHKG2 |
0.818 | -0.047 | -3 | 0.894 |
GSK3B |
0.818 | -0.027 | 4 | 0.444 |
CK1G1 |
0.817 | -0.013 | -3 | 0.615 |
DAPK3 |
0.817 | 0.042 | -3 | 0.881 |
TTBK1 |
0.817 | -0.179 | 2 | 0.650 |
ERK7 |
0.817 | 0.014 | 2 | 0.513 |
CK1A2 |
0.817 | 0.016 | -3 | 0.585 |
CDK6 |
0.815 | 0.076 | 1 | 0.656 |
TAO2 |
0.815 | -0.118 | 2 | 0.840 |
NEK11 |
0.815 | -0.220 | 1 | 0.723 |
CAMKK1 |
0.815 | -0.198 | -2 | 0.724 |
NEK8 |
0.814 | -0.206 | 2 | 0.817 |
PKCE |
0.814 | 0.011 | 2 | 0.715 |
LKB1 |
0.814 | -0.107 | -3 | 0.895 |
IRAK1 |
0.814 | -0.245 | -1 | 0.749 |
PDK1 |
0.813 | -0.112 | 1 | 0.733 |
VRK1 |
0.813 | -0.045 | 2 | 0.872 |
PKCI |
0.813 | -0.065 | 2 | 0.732 |
GCK |
0.813 | -0.059 | 1 | 0.719 |
CDK4 |
0.813 | 0.078 | 1 | 0.632 |
CHK2 |
0.812 | 0.050 | -3 | 0.727 |
MEKK6 |
0.811 | -0.099 | 1 | 0.751 |
CK2A1 |
0.811 | 0.067 | 1 | 0.605 |
NEK4 |
0.811 | -0.149 | 1 | 0.738 |
PAK5 |
0.811 | -0.030 | -2 | 0.608 |
MST2 |
0.811 | -0.133 | 1 | 0.741 |
TNIK |
0.810 | -0.042 | 3 | 0.834 |
SGK1 |
0.810 | 0.088 | -3 | 0.689 |
DAPK1 |
0.810 | 0.011 | -3 | 0.872 |
TAK1 |
0.810 | -0.117 | 1 | 0.743 |
MRCKA |
0.809 | 0.058 | -3 | 0.840 |
CAMK1A |
0.809 | 0.049 | -3 | 0.739 |
PLK2 |
0.809 | -0.048 | -3 | 0.806 |
ROCK2 |
0.809 | 0.080 | -3 | 0.862 |
MAP3K15 |
0.809 | -0.124 | 1 | 0.717 |
MRCKB |
0.809 | 0.058 | -3 | 0.830 |
CAMKK2 |
0.808 | -0.212 | -2 | 0.721 |
PKN1 |
0.808 | -0.009 | -3 | 0.820 |
DMPK1 |
0.808 | 0.127 | -3 | 0.847 |
LRRK2 |
0.808 | -0.174 | 2 | 0.846 |
MINK |
0.808 | -0.107 | 1 | 0.731 |
HGK |
0.807 | -0.108 | 3 | 0.830 |
PAK4 |
0.807 | -0.028 | -2 | 0.623 |
PBK |
0.807 | 0.098 | 1 | 0.776 |
SBK |
0.806 | 0.092 | -3 | 0.654 |
NEK1 |
0.806 | -0.130 | 1 | 0.749 |
HPK1 |
0.805 | -0.098 | 1 | 0.705 |
MST1 |
0.804 | -0.140 | 1 | 0.727 |
AKT3 |
0.804 | 0.057 | -3 | 0.703 |
KHS1 |
0.802 | -0.045 | 1 | 0.715 |
BIKE |
0.802 | 0.145 | 1 | 0.749 |
KHS2 |
0.801 | -0.016 | 1 | 0.720 |
LOK |
0.800 | -0.140 | -2 | 0.751 |
PDHK3_TYR |
0.799 | 0.175 | 4 | 0.894 |
RIPK2 |
0.799 | -0.273 | 1 | 0.684 |
TTK |
0.798 | -0.015 | -2 | 0.848 |
SLK |
0.796 | -0.156 | -2 | 0.710 |
STK33 |
0.796 | -0.216 | 2 | 0.648 |
ROCK1 |
0.796 | 0.052 | -3 | 0.839 |
BUB1 |
0.796 | -0.029 | -5 | 0.799 |
YSK1 |
0.795 | -0.155 | 2 | 0.782 |
MEK2 |
0.794 | -0.332 | 2 | 0.817 |
PKG1 |
0.794 | 0.000 | -2 | 0.565 |
OSR1 |
0.793 | -0.095 | 2 | 0.787 |
HASPIN |
0.793 | -0.040 | -1 | 0.646 |
CRIK |
0.792 | 0.073 | -3 | 0.778 |
MAP2K6_TYR |
0.792 | 0.045 | -1 | 0.895 |
PDHK4_TYR |
0.791 | 0.052 | 2 | 0.906 |
MAP2K4_TYR |
0.791 | -0.017 | -1 | 0.891 |
ALPHAK3 |
0.790 | -0.075 | -1 | 0.793 |
PKMYT1_TYR |
0.790 | 0.000 | 3 | 0.809 |
TESK1_TYR |
0.789 | -0.076 | 3 | 0.840 |
BMPR2_TYR |
0.789 | 0.013 | -1 | 0.889 |
AAK1 |
0.788 | 0.182 | 1 | 0.670 |
PDHK1_TYR |
0.787 | -0.017 | -1 | 0.910 |
NEK3 |
0.787 | -0.222 | 1 | 0.721 |
EPHB4 |
0.787 | 0.093 | -1 | 0.880 |
MAP2K7_TYR |
0.787 | -0.179 | 2 | 0.880 |
ASK1 |
0.787 | -0.178 | 1 | 0.706 |
EPHA6 |
0.786 | 0.071 | -1 | 0.899 |
MYO3B |
0.786 | -0.107 | 2 | 0.797 |
TXK |
0.784 | 0.126 | 1 | 0.773 |
PINK1_TYR |
0.783 | -0.182 | 1 | 0.776 |
YES1 |
0.783 | 0.083 | -1 | 0.870 |
RET |
0.783 | -0.051 | 1 | 0.756 |
ABL2 |
0.782 | 0.064 | -1 | 0.837 |
LIMK2_TYR |
0.782 | -0.039 | -3 | 0.938 |
FGR |
0.781 | 0.035 | 1 | 0.817 |
YANK3 |
0.781 | -0.097 | 2 | 0.438 |
CK1A |
0.780 | -0.022 | -3 | 0.486 |
BLK |
0.780 | 0.148 | -1 | 0.871 |
MYO3A |
0.780 | -0.160 | 1 | 0.718 |
ROS1 |
0.780 | -0.039 | 3 | 0.747 |
TAO1 |
0.780 | -0.162 | 1 | 0.665 |
TYRO3 |
0.779 | -0.066 | 3 | 0.765 |
ITK |
0.779 | 0.062 | -1 | 0.824 |
CSF1R |
0.779 | -0.042 | 3 | 0.750 |
DDR1 |
0.778 | -0.048 | 4 | 0.823 |
LCK |
0.778 | 0.103 | -1 | 0.869 |
ABL1 |
0.778 | 0.046 | -1 | 0.831 |
EPHB2 |
0.778 | 0.064 | -1 | 0.868 |
MST1R |
0.777 | -0.127 | 3 | 0.753 |
TYK2 |
0.777 | -0.153 | 1 | 0.757 |
HCK |
0.777 | 0.025 | -1 | 0.862 |
JAK2 |
0.777 | -0.103 | 1 | 0.762 |
EPHB3 |
0.776 | 0.035 | -1 | 0.871 |
LIMK1_TYR |
0.776 | -0.193 | 2 | 0.857 |
EPHB1 |
0.776 | 0.011 | 1 | 0.787 |
INSRR |
0.776 | -0.046 | 3 | 0.703 |
FYN |
0.775 | 0.128 | -1 | 0.850 |
FER |
0.775 | -0.085 | 1 | 0.813 |
JAK3 |
0.775 | -0.069 | 1 | 0.734 |
EPHA4 |
0.775 | -0.007 | 2 | 0.824 |
SRMS |
0.774 | -0.023 | 1 | 0.784 |
STLK3 |
0.774 | -0.225 | 1 | 0.694 |
BMX |
0.772 | 0.019 | -1 | 0.749 |
TNNI3K_TYR |
0.772 | 0.056 | 1 | 0.815 |
KIT |
0.771 | -0.084 | 3 | 0.746 |
KDR |
0.770 | -0.063 | 3 | 0.710 |
TNK2 |
0.769 | -0.049 | 3 | 0.690 |
FGFR2 |
0.769 | -0.129 | 3 | 0.732 |
FLT3 |
0.769 | -0.104 | 3 | 0.761 |
PDGFRB |
0.768 | -0.126 | 3 | 0.759 |
TEK |
0.768 | -0.115 | 3 | 0.702 |
MERTK |
0.768 | -0.051 | 3 | 0.727 |
DDR2 |
0.767 | 0.076 | 3 | 0.673 |
TEC |
0.767 | -0.039 | -1 | 0.766 |
MET |
0.766 | -0.066 | 3 | 0.720 |
TNK1 |
0.765 | -0.085 | 3 | 0.752 |
FGFR1 |
0.765 | -0.145 | 3 | 0.714 |
JAK1 |
0.765 | -0.088 | 1 | 0.699 |
AXL |
0.764 | -0.115 | 3 | 0.720 |
LYN |
0.764 | -0.002 | 3 | 0.690 |
EPHA7 |
0.764 | -0.037 | 2 | 0.819 |
BTK |
0.764 | -0.130 | -1 | 0.782 |
FLT1 |
0.763 | -0.078 | -1 | 0.863 |
SRC |
0.762 | 0.025 | -1 | 0.846 |
WEE1_TYR |
0.761 | -0.118 | -1 | 0.762 |
EPHA3 |
0.761 | -0.107 | 2 | 0.795 |
FRK |
0.760 | -0.074 | -1 | 0.870 |
NEK10_TYR |
0.760 | -0.179 | 1 | 0.608 |
ERBB2 |
0.760 | -0.152 | 1 | 0.710 |
LTK |
0.759 | -0.120 | 3 | 0.695 |
EPHA5 |
0.759 | -0.035 | 2 | 0.815 |
ALK |
0.759 | -0.161 | 3 | 0.673 |
PTK2B |
0.759 | -0.037 | -1 | 0.815 |
NTRK1 |
0.759 | -0.187 | -1 | 0.854 |
PDGFRA |
0.759 | -0.233 | 3 | 0.764 |
FGFR3 |
0.758 | -0.142 | 3 | 0.700 |
INSR |
0.758 | -0.131 | 3 | 0.682 |
EPHA1 |
0.758 | -0.102 | 3 | 0.703 |
FLT4 |
0.757 | -0.147 | 3 | 0.716 |
CK1G3 |
0.756 | -0.055 | -3 | 0.439 |
EPHA8 |
0.756 | -0.062 | -1 | 0.850 |
PTK6 |
0.755 | -0.213 | -1 | 0.752 |
NTRK2 |
0.755 | -0.198 | 3 | 0.699 |
MATK |
0.754 | -0.116 | -1 | 0.761 |
PTK2 |
0.753 | 0.016 | -1 | 0.821 |
EGFR |
0.753 | -0.081 | 1 | 0.634 |
CSK |
0.753 | -0.107 | 2 | 0.820 |
NTRK3 |
0.752 | -0.153 | -1 | 0.812 |
SYK |
0.751 | -0.000 | -1 | 0.816 |
FGFR4 |
0.746 | -0.121 | -1 | 0.806 |
IGF1R |
0.745 | -0.131 | 3 | 0.624 |
YANK2 |
0.745 | -0.136 | 2 | 0.454 |
EPHA2 |
0.744 | -0.082 | -1 | 0.815 |
ERBB4 |
0.743 | -0.057 | 1 | 0.651 |
CK1G2 |
0.740 | -0.058 | -3 | 0.535 |
MUSK |
0.739 | -0.176 | 1 | 0.613 |
ZAP70 |
0.729 | -0.051 | -1 | 0.733 |
FES |
0.727 | -0.183 | -1 | 0.734 |