Motif 772 (n=147)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B2RTY4 | MYO9A | S48 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O00327 | BMAL1 | S43 | ochoa | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}. |
| O14745 | NHERF1 | S339 | psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O15117 | FYB1 | S734 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15327 | INPP4B | S549 | ochoa | Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}. |
| O43581 | SYT7 | S52 | ochoa | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) | Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. |
| O60271 | SPAG9 | S594 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75131 | CPNE3 | S197 | ochoa | Copine-3 (Copine III) | Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). {ECO:0000269|PubMed:20010870}. |
| O75143 | ATG13 | S389 | ochoa | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75533 | SF3B1 | S485 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O94782 | USP1 | S472 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94876 | TMCC1 | S392 | ochoa | Transmembrane and coiled-coil domains protein 1 | Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}. |
| O94915 | FRYL | S221 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O95251 | KAT7 | S80 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| P00374 | DHFR | S145 | psp | Dihydrofolate reductase (EC 1.5.1.3) | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}. |
| P04899 | GNAI2 | S302 | psp | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05771 | PRKCB | S120 | ochoa | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P06733 | ENO1 | S115 | psp | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07900 | HSP90AA1 | S63 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S58 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P09914 | IFIT1 | S412 | ochoa | Antiviral innate immune response effector IFIT1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) (Interferon-induced protein with tetratricopeptide repeats 1) | Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E (PubMed:21642987, PubMed:27240734, PubMed:39009378, PubMed:23334420, PubMed:28251928, PubMed:36285486). Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro (PubMed:19008854, PubMed:21976647). Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families (PubMed:19008854, PubMed:21976647, PubMed:28251928, PubMed:36285486). {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420, ECO:0000269|PubMed:28251928, ECO:0000269|PubMed:36285486, ECO:0000269|PubMed:39009378}. |
| P11413 | G6PD | S160 | ochoa | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
| P12270 | TPR | S632 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P14314 | PRKCSH | S24 | ochoa | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| P17252 | PRKCA | S120 | ochoa | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P19525 | EIF2AK2 | S242 | psp | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P19525 | EIF2AK2 | S456 | ochoa|psp | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P22102 | GART | S796 | ochoa | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| P38646 | HSPA9 | S65 | psp | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P38646 | HSPA9 | S148 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P47756 | CAPZB | S192 | psp | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| P49368 | CCT3 | S170 | psp | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P53355 | DAPK1 | S366 | ochoa | Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing. |
| P53365 | ARFIP2 | S260 | psp | Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1) | Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network (PubMed:26507660). May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site (PubMed:30917996, PubMed:31204568). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658). {ECO:0000269|PubMed:26296658, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568, ECO:0000269|PubMed:33773106}. |
| P54132 | BLM | S646 | ochoa|psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54278 | PMS2 | S603 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P54296 | MYOM2 | S946 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P60520 | GABARAPL2 | S88 | psp | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein) | Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295). {ECO:0000250|UniProtKB:P60519, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}. |
| P61081 | UBE2M | S50 | ochoa | NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:15361859}. |
| P63241 | EIF5A | S23 | ochoa | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| P78527 | PRKDC | S3018 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q0IIM8 | TBC1D8B | S949 | ochoa | TBC1 domain family member 8B | Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. {ECO:0000269|PubMed:30661770}. |
| Q12888 | TP53BP1 | S862 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12923 | PTPN13 | S1014 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12955 | ANK3 | S1405 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13155 | AIMP2 | S156 | psp | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) | Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}. |
| Q13480 | GAB1 | S419 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13936 | CACNA1C | S1535 | psp | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:25260352, ECO:0000269|PubMed:25633834, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:31430211, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:8099908, ECO:0000305}.; FUNCTION: [Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:8392192}.; FUNCTION: [Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:11741969}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. |
| Q14289 | PTK2B | S361 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14318 | FKBP8 | S296 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}. |
| Q14324 | MYBPC2 | S114 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14739 | LBR | S167 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q15008 | PSMD6 | S361 | ochoa | 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q15018 | ABRAXAS2 | S79 | ochoa | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. |
| Q1MSJ5 | CSPP1 | S77 | ochoa | Centrosome and spindle pole-associated protein 1 | May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}. |
| Q2LD37 | BLTP1 | S1805 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q4LE39 | ARID4B | S930 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
| Q4V9L6 | TMEM119 | S125 | ochoa | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}. |
| Q56NI9 | ESCO2 | S50 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
| Q58FF6 | HSP90AB4P | S34 | ochoa | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF7 | HSP90AB3P | S58 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | S58 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5JSP0 | FGD3 | S446 | ochoa | FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) | Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q5T0W9 | FAM83B | S543 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5VT25 | CDC42BPA | S856 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VTT5 | MYOM3 | S1049 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q658Y4 | FAM91A1 | S310 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q66K74 | MAP1S | S472 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6L8Q7 | PDE12 | S433 | ochoa | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
| Q6P995 | FAM171B | S405 | ochoa | Protein FAM171B | None |
| Q7L576 | CYFIP1 | S583 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7L8S5 | OTUD6A | S70 | psp | OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2) | Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. {ECO:0000269|PubMed:23827681}. |
| Q7Z4S6 | KIF21A | S521 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z736 | PLEKHH3 | S76 | ochoa | Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3) | None |
| Q86VP3 | PACS2 | S416 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86W92 | PPFIBP1 | S460 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8IV53 | DENND1C | S582 | ochoa | DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8IW35 | CEP97 | S500 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IY18 | SMC5 | S627 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8IY63 | AMOTL1 | S809 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IYD8 | FANCM | S1417 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IYU2 | HACE1 | S385 | ochoa|psp | E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) | E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (PubMed:15254018, PubMed:21988917, PubMed:22036506, PubMed:37537642, PubMed:38332367). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (PubMed:21988917). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division (PubMed:21988917). Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (PubMed:22036506, PubMed:37537642, PubMed:38332367). May also act as a transcription regulator via its interaction with RARB (By similarity). {ECO:0000250|UniProtKB:Q3U0D9, ECO:0000269|PubMed:15254018, ECO:0000269|PubMed:21988917, ECO:0000269|PubMed:22036506, ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367}. |
| Q8N1G1 | REXO1 | S499 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N3P4 | VPS8 | S32 | ochoa | Vacuolar protein sorting-associated protein 8 homolog | Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). {ECO:0000269|PubMed:25266290, ECO:0000305|PubMed:25266290}. |
| Q8N8Z6 | DCBLD1 | S513 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8N9N5 | BANP | S76 | ochoa | Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein) | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (By similarity). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest (By similarity). Plays a role in the regulation of alternative splicing (PubMed:26080397). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (PubMed:26080397). {ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625, ECO:0000269|PubMed:26080397}. |
| Q8NA72 | POC5 | S78 | ochoa | Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) | Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. |
| Q8NAN2 | MIGA1 | S289 | ochoa | Mitoguardin 1 (Protein FAM73A) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q8NCN4 | RNF169 | S508 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8TAQ2 | SMARCC2 | S555 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TCJ0 | FBXO25 | S178 | psp | F-box only protein 25 | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). {ECO:0000250}. |
| Q8WVM7 | STAG1 | S756 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q92547 | TOPBP1 | S1504 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q93073 | SECISBP2L | S231 | ochoa | Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) | Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. |
| Q96E17 | RAB3C | S198 | ochoa | Ras-related protein Rab-3C (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P10949}. |
| Q96GV9 | MACIR | S167 | ochoa | Macrophage immunometabolism regulator | Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}. |
| Q96HP0 | DOCK6 | S1308 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96N67 | DOCK7 | S1383 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96P47 | AGAP3 | S332 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1) | GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}. |
| Q96RS0 | TGS1 | S445 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q99683 | MAP3K5 | S1072 | ochoa | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q99698 | LYST | S2149 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99708 | RBBP8 | S593 | ochoa|psp | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q9BRP1 | PDCD2L | S229 | ochoa | Programmed cell death protein 2-like | Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. {ECO:0000269|PubMed:17393540}. |
| Q9BS34 | ZNF670 | S64 | ochoa | Zinc finger protein 670 | May be involved in transcriptional regulation. |
| Q9BSC4 | NOL10 | S475 | ochoa | Nucleolar protein 10 | None |
| Q9BZ29 | DOCK9 | S1283 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9H1A4 | ANAPC1 | S60 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1X3 | DNAJC25 | S299 | ochoa | DnaJ homolog subfamily C member 25 | None |
| Q9H2Y7 | ZNF106 | S673 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9HAZ2 | PRDM16 | S437 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9NP97 | DYNLRB1 | S73 | psp | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. {ECO:0000305|PubMed:36071160}. |
| Q9NQR4 | NIT2 | S26 | ochoa | Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) | Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}. |
| Q9NUW8 | TDP1 | S365 | psp | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}. |
| Q9NX05 | FAM120C | S1031 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 2 (Protein FAM120C) (Tumor antigen BJ-HCC-21) | None |
| Q9NY61 | AATF | S63 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9P2N5 | RBM27 | S884 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UGU0 | TCF20 | S1669 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UH62 | ARMCX3 | S288 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UHD8 | SEPTIN9 | S332 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UHP3 | USP25 | Y740 | ochoa | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117). {ECO:0000269|PubMed:23042150, ECO:0000269|PubMed:28619731, ECO:0000269|PubMed:29518389, ECO:0000269|PubMed:30579117, ECO:0000269|PubMed:30926243, ECO:0000269|PubMed:37339955, ECO:0000269|PubMed:37683630, ECO:0000269|PubMed:38875478}.; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. |
| Q9UL25 | RAB21 | S55 | ochoa | Ras-related protein Rab-21 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18804435, PubMed:25648148, PubMed:31455601). RAB21 is involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601}. |
| Q9ULV3 | CIZ1 | S821 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9ULV4 | CORO1C | S187 | ochoa | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9UPU7 | TBC1D2B | S152 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9UQL6 | HDAC5 | S755 | psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y485 | DMXL1 | S1285 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y5M8 | SRPRB | S219 | ochoa | Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1) | Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity). {ECO:0000250|UniProtKB:P47758}. |
| Q9Y6D5 | ARFGEF2 | S1525 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| U3KPZ7 | LOC127814297 | S829 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| P43034 | PAFAH1B1 | S152 | Sugiyama | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
| P53350 | PLK1 | S529 | SIGNOR | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P05787 | KRT8 | S253 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P30044 | PRDX5 | S168 | Sugiyama | Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}. |
| P54750 | PDE1A | S345 | Sugiyama | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) | Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. {ECO:0000269|PubMed:8557689}. |
| Q13049 | TRIM32 | S55 | SIGNOR | E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) | E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:19349376, PubMed:31123703). Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 (PubMed:22745133). Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (PubMed:37543647). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions (PubMed:32918979). Ubiquitinates XIAP and targets it for proteasomal degradation (PubMed:21628460). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376). May ubiquitinate BBS2 (PubMed:22500027). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703). Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (PubMed:34888944). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-45' to initiate autophagy (PubMed:37943659). {ECO:0000250|UniProtKB:Q8CH72, ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:21628460, ECO:0000269|PubMed:22500027, ECO:0000269|PubMed:22745133, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32918979, ECO:0000269|PubMed:34888944, ECO:0000269|PubMed:37543647, ECO:0000269|PubMed:37943659}.; FUNCTION: (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269). Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269). {ECO:0000269|PubMed:7778269}. |
| P31947 | SFN | S149 | Sugiyama | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| Q8TD16 | BICD2 | S658 | Sugiyama | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q07617 | SPAG1 | S326 | SIGNOR | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
| Q96AY3 | FKBP10 | S523 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP10 (PPIase FKBP10) (EC 5.2.1.8) (65 kDa FK506-binding protein) (65 kDa FKBP) (FKBP-65) (FK506-binding protein 10) (FKBP-10) (Immunophilin FKBP65) (Rotamase) | PPIases accelerate the folding of proteins during protein synthesis. |
| O60885 | BRD4 | S1223 | Sugiyama | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| Q13464 | ROCK1 | S296 | Sugiyama | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q15349 | RPS6KA2 | S640 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q9Y5S2 | CDC42BPB | S853 | Sugiyama | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| P54136 | RARS1 | S336 | Sugiyama | Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) | Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}. |
| Q96KB5 | PBK | S110 | Sugiyama | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| P13667 | PDIA4 | S130 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 0.000076 | 4.117 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001269 | 2.897 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.001764 | 2.753 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.002431 | 2.614 |
| R-HSA-9675135 | Diseases of DNA repair | 0.002562 | 2.591 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.002658 | 2.575 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.004994 | 2.302 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 0.007094 | 2.149 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.008270 | 2.082 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.008270 | 2.082 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.010863 | 1.964 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.006005 | 2.222 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.008062 | 2.094 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.009228 | 2.035 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.009279 | 2.033 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.009228 | 2.035 |
| R-HSA-68886 | M Phase | 0.009807 | 2.008 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.006370 | 2.196 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.004927 | 2.307 |
| R-HSA-194138 | Signaling by VEGF | 0.003622 | 2.441 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.006002 | 2.222 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.009846 | 2.007 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.008270 | 2.082 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.010863 | 1.964 |
| R-HSA-69481 | G2/M Checkpoints | 0.003878 | 2.411 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.004994 | 2.302 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.007094 | 2.149 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.011841 | 1.927 |
| R-HSA-2262752 | Cellular responses to stress | 0.011810 | 1.928 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.012554 | 1.901 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.014326 | 1.844 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 0.020529 | 1.688 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 0.020529 | 1.688 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.040639 | 1.391 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.040639 | 1.391 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.040639 | 1.391 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.040639 | 1.391 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.040639 | 1.391 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.040639 | 1.391 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.040639 | 1.391 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 0.040639 | 1.391 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.040639 | 1.391 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.040639 | 1.391 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.040639 | 1.391 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.040639 | 1.391 |
| R-HSA-8865999 | MET activates PTPN11 | 0.050540 | 1.296 |
| R-HSA-111957 | Cam-PDE 1 activation | 0.079636 | 1.099 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.018672 | 1.729 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.098540 | 1.006 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.098540 | 1.006 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.022292 | 1.652 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.022292 | 1.652 |
| R-HSA-444257 | RSK activation | 0.107847 | 0.967 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.107847 | 0.967 |
| R-HSA-8875656 | MET receptor recycling | 0.107847 | 0.967 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.026176 | 1.582 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.028213 | 1.550 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.028213 | 1.550 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.028213 | 1.550 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.028213 | 1.550 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.030312 | 1.518 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.030312 | 1.518 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.126174 | 0.899 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.144127 | 0.841 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.041678 | 1.380 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.152966 | 0.815 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.161714 | 0.791 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.161714 | 0.791 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.170372 | 0.769 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.021024 | 1.677 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.178941 | 0.747 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.178941 | 0.747 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.065372 | 1.185 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.187422 | 0.727 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.026184 | 1.582 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.068230 | 1.166 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.068230 | 1.166 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.195816 | 0.708 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.029576 | 1.529 |
| R-HSA-180292 | GAB1 signalosome | 0.212347 | 0.673 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.038346 | 1.416 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.038346 | 1.416 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.220485 | 0.657 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.220485 | 0.657 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.042467 | 1.372 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.228540 | 0.641 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.228540 | 0.641 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.236511 | 0.626 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.052904 | 1.277 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.108683 | 0.964 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.112013 | 0.951 |
| R-HSA-380287 | Centrosome maturation | 0.056092 | 1.251 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.252210 | 0.598 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.129043 | 0.889 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.267588 | 0.573 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.132518 | 0.878 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.275159 | 0.560 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.139533 | 0.855 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.282652 | 0.549 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.080844 | 1.092 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.290068 | 0.538 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.254962 | 0.594 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.254962 | 0.594 |
| R-HSA-9833482 | PKR-mediated signaling | 0.232052 | 0.634 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.044116 | 1.355 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.165901 | 0.780 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.045332 | 1.344 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.020277 | 1.693 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.105380 | 0.977 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.262613 | 0.581 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.049806 | 1.303 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.049806 | 1.303 |
| R-HSA-5693538 | Homology Directed Repair | 0.049554 | 1.305 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.070037 | 1.155 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.236511 | 0.626 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.275159 | 0.560 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.275159 | 0.560 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.042110 | 1.376 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.043099 | 1.366 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.109479 | 0.961 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.065372 | 1.185 |
| R-HSA-68877 | Mitotic Prometaphase | 0.179321 | 0.746 |
| R-HSA-9909396 | Circadian clock | 0.069215 | 1.160 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.024202 | 1.616 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.044116 | 1.355 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.062556 | 1.204 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.195816 | 0.708 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.204124 | 0.690 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.095645 | 1.019 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.071530 | 1.146 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.205927 | 0.686 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.024202 | 1.616 |
| R-HSA-1500620 | Meiosis | 0.073352 | 1.135 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.034403 | 1.463 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.079636 | 1.099 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.043888 | 1.358 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.152966 | 0.815 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.028421 | 1.546 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.228540 | 0.641 |
| R-HSA-391251 | Protein folding | 0.285565 | 0.544 |
| R-HSA-5358508 | Mismatch Repair | 0.212347 | 0.673 |
| R-HSA-169131 | Inhibition of PKR | 0.020529 | 1.688 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.030636 | 1.514 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.079636 | 1.099 |
| R-HSA-192905 | vRNP Assembly | 0.135197 | 0.869 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.152966 | 0.815 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.161714 | 0.791 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.054371 | 1.265 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.057055 | 1.244 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.195816 | 0.708 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.204124 | 0.690 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.252210 | 0.598 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.259939 | 0.585 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.267588 | 0.573 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.136015 | 0.866 |
| R-HSA-8949613 | Cristae formation | 0.290068 | 0.538 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.153792 | 0.813 |
| R-HSA-191859 | snRNP Assembly | 0.153792 | 0.813 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.297407 | 0.527 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.201752 | 0.695 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.304642 | 0.516 |
| R-HSA-6798695 | Neutrophil degranulation | 0.229282 | 0.640 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.024202 | 1.616 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.024202 | 1.616 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.020448 | 1.689 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.026176 | 1.582 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.204124 | 0.690 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.107847 | 0.967 |
| R-HSA-3371511 | HSF1 activation | 0.074066 | 1.130 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.204124 | 0.690 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.037021 | 1.432 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.095645 | 1.019 |
| R-HSA-8875878 | MET promotes cell motility | 0.080055 | 1.097 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.051734 | 1.286 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.178941 | 0.747 |
| R-HSA-912446 | Meiotic recombination | 0.125589 | 0.901 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.157400 | 0.803 |
| R-HSA-913531 | Interferon Signaling | 0.128738 | 0.890 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.239677 | 0.620 |
| R-HSA-525793 | Myogenesis | 0.282652 | 0.549 |
| R-HSA-3371556 | Cellular response to heat stress | 0.052971 | 1.276 |
| R-HSA-69275 | G2/M Transition | 0.020762 | 1.683 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.050540 | 1.296 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.016965 | 1.770 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.024202 | 1.616 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.126174 | 0.899 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.041678 | 1.380 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.195816 | 0.708 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.083105 | 1.080 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.021646 | 1.665 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.069215 | 1.160 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.226189 | 0.646 |
| R-HSA-68875 | Mitotic Prophase | 0.051818 | 1.286 |
| R-HSA-418597 | G alpha (z) signalling events | 0.028421 | 1.546 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.267588 | 0.573 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.275159 | 0.560 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.304671 | 0.516 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.125589 | 0.901 |
| R-HSA-5617833 | Cilium Assembly | 0.022555 | 1.647 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.205516 | 0.687 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.065372 | 1.185 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.195816 | 0.708 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.086190 | 1.065 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.086190 | 1.065 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.244401 | 0.612 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.143070 | 0.844 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.038063 | 1.419 |
| R-HSA-9612973 | Autophagy | 0.108383 | 0.965 |
| R-HSA-177929 | Signaling by EGFR | 0.143070 | 0.844 |
| R-HSA-73894 | DNA Repair | 0.018317 | 1.737 |
| R-HSA-6806834 | Signaling by MET | 0.232052 | 0.634 |
| R-HSA-199920 | CREB phosphorylation | 0.089137 | 1.050 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.089137 | 1.050 |
| R-HSA-9683686 | Maturation of spike protein | 0.126174 | 0.899 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.152966 | 0.815 |
| R-HSA-418457 | cGMP effects | 0.170372 | 0.769 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.125589 | 0.901 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.290068 | 0.538 |
| R-HSA-68882 | Mitotic Anaphase | 0.037416 | 1.427 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.034442 | 1.463 |
| R-HSA-1474165 | Reproduction | 0.194146 | 0.712 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.062556 | 1.204 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.195816 | 0.708 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.089309 | 1.049 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.220485 | 0.657 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.105380 | 0.977 |
| R-HSA-112040 | G-protein mediated events | 0.043888 | 1.358 |
| R-HSA-379724 | tRNA Aminoacylation | 0.157400 | 0.803 |
| R-HSA-422356 | Regulation of insulin secretion | 0.105172 | 0.978 |
| R-HSA-8853659 | RET signaling | 0.074066 | 1.130 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.015329 | 1.814 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.018672 | 1.729 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.135197 | 0.869 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.161714 | 0.791 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.170372 | 0.769 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.178941 | 0.747 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.178941 | 0.747 |
| R-HSA-3371568 | Attenuation phase | 0.086190 | 1.065 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.228540 | 0.641 |
| R-HSA-9766229 | Degradation of CDH1 | 0.118752 | 0.925 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.194249 | 0.712 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.224442 | 0.649 |
| R-HSA-1632852 | Macroautophagy | 0.226189 | 0.646 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.026304 | 1.580 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.254962 | 0.594 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.054371 | 1.265 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.056092 | 1.251 |
| R-HSA-9843745 | Adipogenesis | 0.196772 | 0.706 |
| R-HSA-111933 | Calmodulin induced events | 0.074066 | 1.130 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.187422 | 0.727 |
| R-HSA-111997 | CaM pathway | 0.074066 | 1.130 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.282652 | 0.549 |
| R-HSA-69242 | S Phase | 0.095428 | 1.020 |
| R-HSA-9707616 | Heme signaling | 0.037021 | 1.432 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.304671 | 0.516 |
| R-HSA-111885 | Opioid Signalling | 0.118293 | 0.927 |
| R-HSA-111996 | Ca-dependent events | 0.095645 | 1.019 |
| R-HSA-373755 | Semaphorin interactions | 0.038346 | 1.416 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.079062 | 1.102 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.117058 | 0.932 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.178941 | 0.747 |
| R-HSA-198753 | ERK/MAPK targets | 0.236511 | 0.626 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.105380 | 0.977 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.282652 | 0.549 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.290068 | 0.538 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.290068 | 0.538 |
| R-HSA-622312 | Inflammasomes | 0.297407 | 0.527 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.304671 | 0.516 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.155956 | 0.807 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.052635 | 1.279 |
| R-HSA-8983711 | OAS antiviral response | 0.152966 | 0.815 |
| R-HSA-2028269 | Signaling by Hippo | 0.204124 | 0.690 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.117058 | 0.932 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.170372 | 0.769 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.146626 | 0.834 |
| R-HSA-112043 | PLC beta mediated events | 0.161024 | 0.793 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.304671 | 0.516 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.124824 | 0.904 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.146626 | 0.834 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.143070 | 0.844 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.205516 | 0.687 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.148626 | 0.828 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.224442 | 0.649 |
| R-HSA-8939211 | ESR-mediated signaling | 0.277670 | 0.556 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.031586 | 1.501 |
| R-HSA-163685 | Integration of energy metabolism | 0.212704 | 0.672 |
| R-HSA-199991 | Membrane Trafficking | 0.089687 | 1.047 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.221625 | 0.654 |
| R-HSA-597592 | Post-translational protein modification | 0.291220 | 0.536 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.135197 | 0.869 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.154134 | 0.812 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.032471 | 1.489 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.161714 | 0.791 |
| R-HSA-9865881 | Complex III assembly | 0.267588 | 0.573 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.267588 | 0.573 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.034072 | 1.468 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.046605 | 1.332 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.168318 | 0.774 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.252210 | 0.598 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.243495 | 0.614 |
| R-HSA-8978934 | Metabolism of cofactors | 0.197996 | 0.703 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.289386 | 0.539 |
| R-HSA-162582 | Signal Transduction | 0.280133 | 0.553 |
| R-HSA-4086400 | PCP/CE pathway | 0.061043 | 1.214 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.270808 | 0.567 |
| R-HSA-422475 | Axon guidance | 0.135831 | 0.867 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.046263 | 1.335 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.194249 | 0.712 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.275159 | 0.560 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.201752 | 0.695 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.228245 | 0.642 |
| R-HSA-9675108 | Nervous system development | 0.176260 | 0.754 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.063138 | 1.200 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.054371 | 1.265 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.074066 | 1.130 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.252210 | 0.598 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.098860 | 1.005 |
| R-HSA-3000170 | Syndecan interactions | 0.259939 | 0.585 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.275159 | 0.560 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.224442 | 0.649 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.304642 | 0.516 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.140197 | 0.853 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.140197 | 0.853 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.231629 | 0.635 |
| R-HSA-212436 | Generic Transcription Pathway | 0.199837 | 0.699 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.083105 | 1.080 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.164664 | 0.783 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.251137 | 0.600 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.258787 | 0.587 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.257180 | 0.590 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.282652 | 0.549 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.212704 | 0.672 |
| R-HSA-74160 | Gene expression (Transcription) | 0.245354 | 0.610 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.080772 | 1.093 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.253615 | 0.596 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.220485 | 0.657 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.290068 | 0.538 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.031065 | 1.508 |
| R-HSA-69206 | G1/S Transition | 0.178586 | 0.748 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.185485 | 0.732 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.096467 | 1.016 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.212704 | 0.672 |
| R-HSA-1500931 | Cell-Cell communication | 0.138244 | 0.859 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.256386 | 0.591 |
| R-HSA-418990 | Adherens junctions interactions | 0.234807 | 0.629 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.077058 | 1.113 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.297020 | 0.527 |
| R-HSA-5357801 | Programmed Cell Death | 0.086297 | 1.064 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.165901 | 0.780 |
| R-HSA-109581 | Apoptosis | 0.118593 | 0.926 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.252669 | 0.597 |
| R-HSA-9679506 | SARS-CoV Infections | 0.249785 | 0.602 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.215387 | 0.667 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.242580 | 0.615 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.175667 | 0.755 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.197996 | 0.703 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.259160 | 0.586 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.258787 | 0.587 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.115144 | 0.939 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.281742 | 0.550 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.216853 | 0.664 |
| R-HSA-449147 | Signaling by Interleukins | 0.229306 | 0.640 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.083105 | 1.080 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.129043 | 0.889 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.262613 | 0.581 |
| R-HSA-4839726 | Chromatin organization | 0.305377 | 0.515 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.308448 | 0.511 |
| R-HSA-421270 | Cell-cell junction organization | 0.310028 | 0.509 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.311861 | 0.506 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.311861 | 0.506 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.311861 | 0.506 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.311861 | 0.506 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.311861 | 0.506 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.311861 | 0.506 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.311861 | 0.506 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.316047 | 0.500 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.318977 | 0.496 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.318977 | 0.496 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.318977 | 0.496 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.318977 | 0.496 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.318977 | 0.496 |
| R-HSA-5688426 | Deubiquitination | 0.319349 | 0.496 |
| R-HSA-70171 | Glycolysis | 0.319840 | 0.495 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.320919 | 0.494 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.322714 | 0.491 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.323628 | 0.490 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.323743 | 0.490 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.323971 | 0.489 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.326019 | 0.487 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.326019 | 0.487 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.326019 | 0.487 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.327410 | 0.485 |
| R-HSA-1483255 | PI Metabolism | 0.327410 | 0.485 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.332989 | 0.478 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.332989 | 0.478 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.332989 | 0.478 |
| R-HSA-9930044 | Nuclear RNA decay | 0.332989 | 0.478 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.332989 | 0.478 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.332989 | 0.478 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.332989 | 0.478 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.332989 | 0.478 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.336967 | 0.472 |
| R-HSA-168255 | Influenza Infection | 0.337862 | 0.471 |
| R-HSA-390522 | Striated Muscle Contraction | 0.339888 | 0.469 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.339888 | 0.469 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.339888 | 0.469 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.339888 | 0.469 |
| R-HSA-2559583 | Cellular Senescence | 0.340685 | 0.468 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.346715 | 0.460 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.346715 | 0.460 |
| R-HSA-203615 | eNOS activation | 0.346715 | 0.460 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.346715 | 0.460 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.346715 | 0.460 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.346715 | 0.460 |
| R-HSA-392518 | Signal amplification | 0.346715 | 0.460 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.346715 | 0.460 |
| R-HSA-69239 | Synthesis of DNA | 0.349979 | 0.456 |
| R-HSA-211000 | Gene Silencing by RNA | 0.349979 | 0.456 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.349979 | 0.456 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.349979 | 0.456 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.353473 | 0.452 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.353473 | 0.452 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.353473 | 0.452 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.353473 | 0.452 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.353473 | 0.452 |
| R-HSA-169911 | Regulation of Apoptosis | 0.353473 | 0.452 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.353716 | 0.451 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.357447 | 0.447 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.357447 | 0.447 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.360161 | 0.444 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.360161 | 0.444 |
| R-HSA-202403 | TCR signaling | 0.361169 | 0.442 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.366780 | 0.436 |
| R-HSA-4641258 | Degradation of DVL | 0.366780 | 0.436 |
| R-HSA-4641257 | Degradation of AXIN | 0.366780 | 0.436 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.366780 | 0.436 |
| R-HSA-419037 | NCAM1 interactions | 0.366780 | 0.436 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.366780 | 0.436 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.368591 | 0.433 |
| R-HSA-168256 | Immune System | 0.369371 | 0.433 |
| R-HSA-446728 | Cell junction organization | 0.373214 | 0.428 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.373331 | 0.428 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.373331 | 0.428 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.373331 | 0.428 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.379814 | 0.420 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.379814 | 0.420 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.379814 | 0.420 |
| R-HSA-69541 | Stabilization of p53 | 0.379814 | 0.420 |
| R-HSA-71336 | Pentose phosphate pathway | 0.379814 | 0.420 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.386231 | 0.413 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.386231 | 0.413 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.386231 | 0.413 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.386231 | 0.413 |
| R-HSA-9646399 | Aggrephagy | 0.386231 | 0.413 |
| R-HSA-202433 | Generation of second messenger molecules | 0.386231 | 0.413 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.386231 | 0.413 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.386231 | 0.413 |
| R-HSA-373760 | L1CAM interactions | 0.390647 | 0.408 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.392582 | 0.406 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.392582 | 0.406 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.392582 | 0.406 |
| R-HSA-9694548 | Maturation of spike protein | 0.392582 | 0.406 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.392582 | 0.406 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.392582 | 0.406 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.392582 | 0.406 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.392582 | 0.406 |
| R-HSA-70326 | Glucose metabolism | 0.394291 | 0.404 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.394291 | 0.404 |
| R-HSA-112316 | Neuronal System | 0.396727 | 0.402 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.398868 | 0.399 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.398868 | 0.399 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.398868 | 0.399 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.398868 | 0.399 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.398868 | 0.399 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.398868 | 0.399 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.398868 | 0.399 |
| R-HSA-991365 | Activation of GABAB receptors | 0.405089 | 0.392 |
| R-HSA-977444 | GABA B receptor activation | 0.405089 | 0.392 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.408647 | 0.389 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.411246 | 0.386 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.411246 | 0.386 |
| R-HSA-8854214 | TBC/RABGAPs | 0.411246 | 0.386 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.411246 | 0.386 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.411246 | 0.386 |
| R-HSA-1483257 | Phospholipid metabolism | 0.412893 | 0.384 |
| R-HSA-9907900 | Proteasome assembly | 0.417340 | 0.380 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.417340 | 0.380 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.417340 | 0.380 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.417340 | 0.380 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.419511 | 0.377 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.423371 | 0.373 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.423371 | 0.373 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.423371 | 0.373 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.423371 | 0.373 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.423371 | 0.373 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.423371 | 0.373 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.423371 | 0.373 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.423371 | 0.373 |
| R-HSA-9824272 | Somitogenesis | 0.423371 | 0.373 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.429340 | 0.367 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.429340 | 0.367 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.429340 | 0.367 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.429340 | 0.367 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.429340 | 0.367 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.429340 | 0.367 |
| R-HSA-75153 | Apoptotic execution phase | 0.429340 | 0.367 |
| R-HSA-437239 | Recycling pathway of L1 | 0.435247 | 0.361 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.435247 | 0.361 |
| R-HSA-5620924 | Intraflagellar transport | 0.441094 | 0.355 |
| R-HSA-9634597 | GPER1 signaling | 0.441094 | 0.355 |
| R-HSA-70263 | Gluconeogenesis | 0.441094 | 0.355 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.446880 | 0.350 |
| R-HSA-73893 | DNA Damage Bypass | 0.446880 | 0.350 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.446880 | 0.350 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.446880 | 0.350 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.446880 | 0.350 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.452607 | 0.344 |
| R-HSA-109704 | PI3K Cascade | 0.452607 | 0.344 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.452607 | 0.344 |
| R-HSA-8951664 | Neddylation | 0.456985 | 0.340 |
| R-HSA-109582 | Hemostasis | 0.457195 | 0.340 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.458035 | 0.339 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.458275 | 0.339 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.458275 | 0.339 |
| R-HSA-2514856 | The phototransduction cascade | 0.458275 | 0.339 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.463885 | 0.334 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.463885 | 0.334 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.463885 | 0.334 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.463885 | 0.334 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.463885 | 0.334 |
| R-HSA-392499 | Metabolism of proteins | 0.464235 | 0.333 |
| R-HSA-1221632 | Meiotic synapsis | 0.469437 | 0.328 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.469437 | 0.328 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.469437 | 0.328 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.469437 | 0.328 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.469437 | 0.328 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.476933 | 0.322 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.480370 | 0.318 |
| R-HSA-6807070 | PTEN Regulation | 0.481776 | 0.317 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.481776 | 0.317 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.482727 | 0.316 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.485752 | 0.314 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.485752 | 0.314 |
| R-HSA-112399 | IRS-mediated signalling | 0.491079 | 0.309 |
| R-HSA-1483166 | Synthesis of PA | 0.491079 | 0.309 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.501568 | 0.300 |
| R-HSA-180786 | Extension of Telomeres | 0.501568 | 0.300 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.506732 | 0.295 |
| R-HSA-977443 | GABA receptor activation | 0.506732 | 0.295 |
| R-HSA-983189 | Kinesins | 0.506732 | 0.295 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.506732 | 0.295 |
| R-HSA-351202 | Metabolism of polyamines | 0.506732 | 0.295 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.506732 | 0.295 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.506732 | 0.295 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.506732 | 0.295 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.506732 | 0.295 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.506732 | 0.295 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.511348 | 0.291 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.511843 | 0.291 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.511843 | 0.291 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.511843 | 0.291 |
| R-HSA-450294 | MAP kinase activation | 0.511843 | 0.291 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.511843 | 0.291 |
| R-HSA-166520 | Signaling by NTRKs | 0.514566 | 0.289 |
| R-HSA-1268020 | Mitochondrial protein import | 0.516901 | 0.287 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.516901 | 0.287 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.516901 | 0.287 |
| R-HSA-6799198 | Complex I biogenesis | 0.521907 | 0.282 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.521907 | 0.282 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.526862 | 0.278 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.526862 | 0.278 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.526862 | 0.278 |
| R-HSA-69306 | DNA Replication | 0.530444 | 0.275 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.531765 | 0.274 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.531765 | 0.274 |
| R-HSA-73887 | Death Receptor Signaling | 0.533577 | 0.273 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.536618 | 0.270 |
| R-HSA-1989781 | PPARA activates gene expression | 0.536696 | 0.270 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.536696 | 0.270 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.541421 | 0.266 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.542892 | 0.265 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.545968 | 0.263 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.546174 | 0.263 |
| R-HSA-5218859 | Regulated Necrosis | 0.546174 | 0.263 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.552077 | 0.258 |
| R-HSA-448424 | Interleukin-17 signaling | 0.555535 | 0.255 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.555535 | 0.255 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.555535 | 0.255 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.560143 | 0.252 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.560143 | 0.252 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.560143 | 0.252 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.560143 | 0.252 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.563343 | 0.249 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.564123 | 0.249 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.564703 | 0.248 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.564703 | 0.248 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.564703 | 0.248 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.564703 | 0.248 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.569217 | 0.245 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.569217 | 0.245 |
| R-HSA-4086398 | Ca2+ pathway | 0.569217 | 0.245 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.573683 | 0.241 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.573683 | 0.241 |
| R-HSA-1266738 | Developmental Biology | 0.573796 | 0.241 |
| R-HSA-8852135 | Protein ubiquitination | 0.578104 | 0.238 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.578104 | 0.238 |
| R-HSA-5689603 | UCH proteinases | 0.582480 | 0.235 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.582480 | 0.235 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.586810 | 0.232 |
| R-HSA-418555 | G alpha (s) signalling events | 0.587516 | 0.231 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.587516 | 0.231 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.589828 | 0.229 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.590374 | 0.229 |
| R-HSA-5619084 | ABC transporter disorders | 0.591095 | 0.228 |
| R-HSA-9659379 | Sensory processing of sound | 0.595337 | 0.225 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.598862 | 0.223 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.599535 | 0.222 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.599535 | 0.222 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.599535 | 0.222 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.603689 | 0.219 |
| R-HSA-9658195 | Leishmania infection | 0.605767 | 0.218 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.605767 | 0.218 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.607800 | 0.216 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.611870 | 0.213 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.615897 | 0.210 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.619882 | 0.208 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.623827 | 0.205 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.631594 | 0.200 |
| R-HSA-9663891 | Selective autophagy | 0.635418 | 0.197 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.636405 | 0.196 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.639202 | 0.194 |
| R-HSA-195721 | Signaling by WNT | 0.642753 | 0.192 |
| R-HSA-202424 | Downstream TCR signaling | 0.642947 | 0.192 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.644472 | 0.191 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.646654 | 0.189 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.653953 | 0.184 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.653953 | 0.184 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.653953 | 0.184 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.661102 | 0.180 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.661102 | 0.180 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.664487 | 0.178 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.668104 | 0.175 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.669348 | 0.174 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.671550 | 0.173 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.671550 | 0.173 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.671757 | 0.173 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.671757 | 0.173 |
| R-HSA-157579 | Telomere Maintenance | 0.674962 | 0.171 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.674962 | 0.171 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.678338 | 0.169 |
| R-HSA-190236 | Signaling by FGFR | 0.678338 | 0.169 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.678338 | 0.169 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.678338 | 0.169 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.678338 | 0.169 |
| R-HSA-3214847 | HATs acetylate histones | 0.681679 | 0.166 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.681679 | 0.166 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.684986 | 0.164 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.684986 | 0.164 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.688258 | 0.162 |
| R-HSA-72766 | Translation | 0.688828 | 0.162 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.691497 | 0.160 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.691497 | 0.160 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.691497 | 0.160 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.692620 | 0.160 |
| R-HSA-8957322 | Metabolism of steroids | 0.694502 | 0.158 |
| R-HSA-397014 | Muscle contraction | 0.695077 | 0.158 |
| R-HSA-9833110 | RSV-host interactions | 0.701014 | 0.154 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.704121 | 0.152 |
| R-HSA-418346 | Platelet homeostasis | 0.707196 | 0.150 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.707196 | 0.150 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.710239 | 0.149 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.713251 | 0.147 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.713251 | 0.147 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.716232 | 0.145 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.719182 | 0.143 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.719182 | 0.143 |
| R-HSA-388396 | GPCR downstream signalling | 0.722112 | 0.141 |
| R-HSA-162906 | HIV Infection | 0.727489 | 0.138 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.727849 | 0.138 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.733480 | 0.135 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.736251 | 0.133 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.747054 | 0.127 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.749685 | 0.125 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.749685 | 0.125 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.749685 | 0.125 |
| R-HSA-168249 | Innate Immune System | 0.751106 | 0.124 |
| R-HSA-157118 | Signaling by NOTCH | 0.753191 | 0.123 |
| R-HSA-73886 | Chromosome Maintenance | 0.754866 | 0.122 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.754866 | 0.122 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.757417 | 0.121 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.757417 | 0.121 |
| R-HSA-9824446 | Viral Infection Pathways | 0.758877 | 0.120 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.759941 | 0.119 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.759941 | 0.119 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.762439 | 0.118 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.766152 | 0.116 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.774546 | 0.111 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.779216 | 0.108 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.781949 | 0.107 |
| R-HSA-1280218 | Adaptive Immune System | 0.782932 | 0.106 |
| R-HSA-5576891 | Cardiac conduction | 0.783789 | 0.106 |
| R-HSA-8953854 | Metabolism of RNA | 0.789249 | 0.103 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.793586 | 0.100 |
| R-HSA-416476 | G alpha (q) signalling events | 0.795203 | 0.100 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.801159 | 0.096 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.801159 | 0.096 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.801608 | 0.096 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.805280 | 0.094 |
| R-HSA-9664407 | Parasite infection | 0.805280 | 0.094 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.805280 | 0.094 |
| R-HSA-372790 | Signaling by GPCR | 0.810279 | 0.091 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.811304 | 0.091 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.815216 | 0.089 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.818155 | 0.087 |
| R-HSA-2187338 | Visual phototransduction | 0.820934 | 0.086 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.822800 | 0.085 |
| R-HSA-418594 | G alpha (i) signalling events | 0.823211 | 0.084 |
| R-HSA-9758941 | Gastrulation | 0.824647 | 0.084 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.826475 | 0.083 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.830075 | 0.081 |
| R-HSA-9609507 | Protein localization | 0.831847 | 0.080 |
| R-HSA-9610379 | HCMV Late Events | 0.838752 | 0.076 |
| R-HSA-162587 | HIV Life Cycle | 0.838752 | 0.076 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.840587 | 0.075 |
| R-HSA-5619102 | SLC transporter disorders | 0.854807 | 0.068 |
| R-HSA-72306 | tRNA processing | 0.860775 | 0.065 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.865090 | 0.063 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.865090 | 0.063 |
| R-HSA-611105 | Respiratory electron transport | 0.871989 | 0.059 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.873718 | 0.059 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.878536 | 0.056 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.888327 | 0.051 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.891793 | 0.050 |
| R-HSA-9609690 | HCMV Early Events | 0.894044 | 0.049 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.901561 | 0.045 |
| R-HSA-72172 | mRNA Splicing | 0.903610 | 0.044 |
| R-HSA-6805567 | Keratinization | 0.905617 | 0.043 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.909768 | 0.041 |
| R-HSA-5663205 | Infectious disease | 0.911435 | 0.040 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.926687 | 0.033 |
| R-HSA-15869 | Metabolism of nucleotides | 0.931178 | 0.031 |
| R-HSA-9609646 | HCMV Infection | 0.940622 | 0.027 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.955818 | 0.020 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.960667 | 0.017 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.963474 | 0.016 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.963477 | 0.016 |
| R-HSA-1643685 | Disease | 0.971709 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 0.974787 | 0.011 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.977324 | 0.010 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.978722 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 0.990487 | 0.004 |
| R-HSA-211859 | Biological oxidations | 0.996783 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.999669 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999978 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999981 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.859 | 0.119 | 2 | 0.856 |
RAF1 |
0.854 | 0.320 | 1 | 0.759 |
PKN3 |
0.854 | 0.227 | -3 | 0.900 |
CAMK1B |
0.854 | 0.257 | -3 | 0.919 |
NDR1 |
0.852 | 0.224 | -3 | 0.910 |
WNK1 |
0.852 | 0.228 | -2 | 0.929 |
NDR2 |
0.852 | 0.158 | -3 | 0.890 |
TBK1 |
0.852 | 0.270 | 1 | 0.731 |
RSK2 |
0.852 | 0.270 | -3 | 0.898 |
PRKD2 |
0.851 | 0.264 | -3 | 0.884 |
PIM3 |
0.851 | 0.201 | -3 | 0.906 |
NUAK2 |
0.851 | 0.223 | -3 | 0.919 |
MST4 |
0.850 | 0.207 | 2 | 0.775 |
AMPKA1 |
0.850 | 0.220 | -3 | 0.909 |
PKN2 |
0.850 | 0.228 | -3 | 0.902 |
MAPKAPK3 |
0.850 | 0.242 | -3 | 0.894 |
P90RSK |
0.850 | 0.260 | -3 | 0.894 |
PIM1 |
0.849 | 0.270 | -3 | 0.900 |
CDKL1 |
0.848 | 0.239 | -3 | 0.902 |
CAMK2D |
0.848 | 0.228 | -3 | 0.898 |
SRPK1 |
0.848 | 0.248 | -3 | 0.874 |
RSK3 |
0.848 | 0.252 | -3 | 0.890 |
IKKE |
0.848 | 0.263 | 1 | 0.741 |
PRKD1 |
0.848 | 0.197 | -3 | 0.887 |
MAPKAPK2 |
0.848 | 0.238 | -3 | 0.877 |
SRPK2 |
0.847 | 0.272 | -3 | 0.842 |
AMPKA2 |
0.847 | 0.226 | -3 | 0.907 |
PKCD |
0.847 | 0.215 | 2 | 0.739 |
MARK4 |
0.847 | 0.159 | 4 | 0.834 |
DSTYK |
0.847 | 0.102 | 2 | 0.840 |
PKACG |
0.846 | 0.224 | -2 | 0.822 |
P70S6KB |
0.846 | 0.251 | -3 | 0.912 |
NUAK1 |
0.846 | 0.214 | -3 | 0.909 |
MTOR |
0.845 | 0.060 | 1 | 0.684 |
CLK3 |
0.845 | 0.151 | 1 | 0.626 |
LATS2 |
0.845 | 0.158 | -5 | 0.785 |
SIK |
0.845 | 0.245 | -3 | 0.885 |
ULK2 |
0.844 | -0.001 | 2 | 0.751 |
IKKB |
0.844 | 0.089 | -2 | 0.834 |
TSSK1 |
0.844 | 0.204 | -3 | 0.909 |
HUNK |
0.843 | 0.089 | 2 | 0.781 |
MELK |
0.843 | 0.227 | -3 | 0.904 |
NIM1 |
0.843 | 0.155 | 3 | 0.841 |
PDHK1 |
0.843 | 0.159 | 1 | 0.758 |
NIK |
0.843 | 0.232 | -3 | 0.898 |
PRKD3 |
0.843 | 0.261 | -3 | 0.876 |
CDKL5 |
0.842 | 0.191 | -3 | 0.902 |
CDC7 |
0.842 | -0.034 | 1 | 0.648 |
CAMK2B |
0.842 | 0.208 | 2 | 0.794 |
PDHK4 |
0.841 | 0.037 | 1 | 0.733 |
MSK2 |
0.841 | 0.218 | -3 | 0.874 |
TSSK2 |
0.841 | 0.161 | -5 | 0.860 |
PRPK |
0.841 | -0.062 | -1 | 0.819 |
BCKDK |
0.841 | 0.141 | -1 | 0.799 |
CAMK2G |
0.841 | 0.027 | 2 | 0.807 |
QSK |
0.841 | 0.201 | 4 | 0.817 |
CAMK4 |
0.840 | 0.157 | -3 | 0.902 |
QIK |
0.840 | 0.183 | -3 | 0.892 |
SGK3 |
0.840 | 0.288 | -3 | 0.888 |
RSK4 |
0.840 | 0.264 | -3 | 0.877 |
SKMLCK |
0.840 | 0.147 | -2 | 0.914 |
CAMLCK |
0.840 | 0.173 | -2 | 0.903 |
WNK3 |
0.839 | 0.100 | 1 | 0.709 |
ATR |
0.838 | 0.042 | 1 | 0.702 |
GCN2 |
0.838 | -0.134 | 2 | 0.748 |
NEK7 |
0.838 | 0.002 | -3 | 0.805 |
MNK2 |
0.838 | 0.145 | -2 | 0.856 |
CAMK2A |
0.837 | 0.197 | 2 | 0.783 |
PKACB |
0.837 | 0.236 | -2 | 0.740 |
AKT2 |
0.837 | 0.284 | -3 | 0.855 |
DNAPK |
0.837 | 0.219 | 1 | 0.743 |
BRSK1 |
0.837 | 0.190 | -3 | 0.896 |
NEK6 |
0.837 | 0.008 | -2 | 0.921 |
NLK |
0.837 | 0.025 | 1 | 0.654 |
SRPK3 |
0.837 | 0.238 | -3 | 0.856 |
MSK1 |
0.837 | 0.229 | -3 | 0.885 |
DAPK2 |
0.836 | 0.168 | -3 | 0.910 |
RIPK3 |
0.836 | 0.019 | 3 | 0.799 |
MOS |
0.836 | -0.038 | 1 | 0.652 |
PKCG |
0.836 | 0.165 | 2 | 0.678 |
ULK1 |
0.836 | -0.042 | -3 | 0.778 |
FAM20C |
0.835 | 0.151 | 2 | 0.701 |
ICK |
0.835 | 0.166 | -3 | 0.911 |
CAMK1G |
0.835 | 0.207 | -3 | 0.895 |
PKCB |
0.835 | 0.151 | 2 | 0.675 |
CLK1 |
0.835 | 0.227 | -3 | 0.883 |
TGFBR2 |
0.834 | 0.020 | -2 | 0.821 |
MARK3 |
0.834 | 0.154 | 4 | 0.767 |
MAPKAPK5 |
0.834 | 0.190 | -3 | 0.871 |
PAK3 |
0.834 | 0.124 | -2 | 0.823 |
MYLK4 |
0.833 | 0.190 | -2 | 0.833 |
BRSK2 |
0.833 | 0.142 | -3 | 0.898 |
ATM |
0.833 | 0.059 | 1 | 0.677 |
LATS1 |
0.833 | 0.212 | -3 | 0.895 |
AURC |
0.833 | 0.145 | -2 | 0.709 |
BMPR2 |
0.833 | -0.103 | -2 | 0.933 |
PAK1 |
0.833 | 0.132 | -2 | 0.819 |
PKCA |
0.833 | 0.159 | 2 | 0.667 |
PAK6 |
0.833 | 0.150 | -2 | 0.740 |
PKCH |
0.832 | 0.155 | 2 | 0.669 |
PHKG1 |
0.832 | 0.145 | -3 | 0.899 |
MARK1 |
0.832 | 0.170 | 4 | 0.790 |
PKG2 |
0.832 | 0.198 | -2 | 0.745 |
MARK2 |
0.832 | 0.146 | 4 | 0.737 |
PRKX |
0.831 | 0.246 | -3 | 0.837 |
HIPK4 |
0.831 | 0.090 | 1 | 0.606 |
CHK1 |
0.831 | 0.165 | -3 | 0.896 |
CAMK1D |
0.831 | 0.265 | -3 | 0.852 |
PIM2 |
0.831 | 0.258 | -3 | 0.892 |
AKT1 |
0.831 | 0.268 | -3 | 0.866 |
CLK4 |
0.830 | 0.200 | -3 | 0.896 |
RIPK1 |
0.830 | 0.008 | 1 | 0.666 |
AURB |
0.829 | 0.147 | -2 | 0.710 |
MNK1 |
0.829 | 0.130 | -2 | 0.869 |
SNRK |
0.829 | 0.084 | 2 | 0.651 |
PKACA |
0.828 | 0.240 | -2 | 0.687 |
NEK9 |
0.828 | -0.017 | 2 | 0.777 |
PHKG2 |
0.828 | 0.203 | -3 | 0.891 |
DCAMKL1 |
0.828 | 0.215 | -3 | 0.889 |
P70S6K |
0.827 | 0.241 | -3 | 0.874 |
ANKRD3 |
0.827 | 0.033 | 1 | 0.709 |
NEK2 |
0.826 | 0.095 | 2 | 0.736 |
GRK6 |
0.826 | -0.016 | 1 | 0.668 |
IKKA |
0.826 | 0.017 | -2 | 0.819 |
PKCT |
0.826 | 0.174 | 2 | 0.678 |
ERK5 |
0.826 | -0.065 | 1 | 0.609 |
PLK1 |
0.825 | 0.038 | -2 | 0.870 |
MLK1 |
0.825 | -0.101 | 2 | 0.757 |
MASTL |
0.825 | -0.100 | -2 | 0.891 |
CHAK2 |
0.825 | -0.047 | -1 | 0.808 |
CLK2 |
0.825 | 0.226 | -3 | 0.882 |
IRE1 |
0.824 | -0.020 | 1 | 0.627 |
GRK5 |
0.824 | -0.141 | -3 | 0.799 |
PAK2 |
0.824 | 0.102 | -2 | 0.808 |
IRE2 |
0.824 | 0.025 | 2 | 0.725 |
DCAMKL2 |
0.824 | 0.170 | -3 | 0.905 |
DLK |
0.823 | -0.038 | 1 | 0.688 |
AURA |
0.823 | 0.132 | -2 | 0.675 |
WNK4 |
0.823 | 0.145 | -2 | 0.912 |
DYRK2 |
0.822 | 0.068 | 1 | 0.513 |
SSTK |
0.822 | 0.129 | 4 | 0.822 |
PKCZ |
0.822 | 0.060 | 2 | 0.717 |
CAMK1A |
0.822 | 0.258 | -3 | 0.828 |
SMMLCK |
0.822 | 0.200 | -3 | 0.908 |
PKN1 |
0.822 | 0.223 | -3 | 0.879 |
AKT3 |
0.821 | 0.283 | -3 | 0.811 |
PLK4 |
0.821 | 0.052 | 2 | 0.615 |
SGK1 |
0.821 | 0.301 | -3 | 0.807 |
TTBK2 |
0.820 | -0.067 | 2 | 0.664 |
YSK4 |
0.820 | 0.095 | 1 | 0.713 |
KIS |
0.820 | -0.031 | 1 | 0.520 |
MRCKA |
0.820 | 0.306 | -3 | 0.893 |
BRAF |
0.819 | 0.106 | -4 | 0.779 |
GRK1 |
0.818 | -0.014 | -2 | 0.833 |
MLK2 |
0.818 | -0.108 | 2 | 0.756 |
GRK4 |
0.818 | -0.102 | -2 | 0.895 |
PKR |
0.818 | 0.021 | 1 | 0.677 |
MRCKB |
0.817 | 0.289 | -3 | 0.879 |
DYRK1A |
0.817 | 0.136 | 1 | 0.563 |
PKCI |
0.816 | 0.130 | 2 | 0.679 |
CHK2 |
0.816 | 0.266 | -3 | 0.822 |
ALK4 |
0.816 | -0.043 | -2 | 0.850 |
PAK5 |
0.816 | 0.126 | -2 | 0.672 |
PKCE |
0.814 | 0.175 | 2 | 0.660 |
PLK3 |
0.814 | -0.013 | 2 | 0.761 |
HIPK1 |
0.814 | 0.110 | 1 | 0.520 |
CHAK1 |
0.814 | -0.035 | 2 | 0.697 |
MEK1 |
0.814 | -0.065 | 2 | 0.787 |
MLK3 |
0.814 | -0.064 | 2 | 0.679 |
DRAK1 |
0.814 | -0.017 | 1 | 0.602 |
TGFBR1 |
0.814 | -0.037 | -2 | 0.821 |
TLK1 |
0.813 | 0.037 | -2 | 0.881 |
CDK7 |
0.812 | -0.043 | 1 | 0.493 |
PAK4 |
0.812 | 0.113 | -2 | 0.679 |
CDK8 |
0.812 | -0.073 | 1 | 0.482 |
BMPR1B |
0.811 | -0.020 | 1 | 0.588 |
MST3 |
0.811 | 0.124 | 2 | 0.752 |
JNK2 |
0.811 | 0.011 | 1 | 0.472 |
ROCK2 |
0.811 | 0.284 | -3 | 0.897 |
ZAK |
0.811 | -0.001 | 1 | 0.677 |
IRAK4 |
0.811 | 0.013 | 1 | 0.652 |
DAPK3 |
0.810 | 0.191 | -3 | 0.902 |
HIPK3 |
0.810 | 0.095 | 1 | 0.548 |
SBK |
0.810 | 0.262 | -3 | 0.782 |
HIPK2 |
0.810 | 0.074 | 1 | 0.434 |
DYRK1B |
0.810 | 0.080 | 1 | 0.458 |
HRI |
0.809 | -0.064 | -2 | 0.899 |
MEKK3 |
0.809 | -0.008 | 1 | 0.692 |
SMG1 |
0.809 | -0.052 | 1 | 0.679 |
DYRK3 |
0.809 | 0.130 | 1 | 0.526 |
VRK2 |
0.809 | -0.181 | 1 | 0.685 |
TLK2 |
0.808 | -0.032 | 1 | 0.698 |
CDK5 |
0.808 | -0.019 | 1 | 0.497 |
GRK7 |
0.807 | -0.012 | 1 | 0.611 |
TAO3 |
0.807 | 0.091 | 1 | 0.696 |
DYRK4 |
0.807 | 0.063 | 1 | 0.446 |
CDK13 |
0.807 | -0.051 | 1 | 0.477 |
MEK5 |
0.807 | -0.057 | 2 | 0.768 |
NEK5 |
0.807 | -0.000 | 1 | 0.685 |
ALK2 |
0.807 | -0.039 | -2 | 0.829 |
MLK4 |
0.806 | -0.110 | 2 | 0.669 |
NEK4 |
0.806 | 0.171 | 1 | 0.727 |
IRAK1 |
0.806 | -0.032 | -1 | 0.718 |
CDK19 |
0.806 | -0.070 | 1 | 0.450 |
MEKK2 |
0.805 | -0.002 | 2 | 0.752 |
ACVR2A |
0.805 | -0.077 | -2 | 0.819 |
CDK14 |
0.805 | 0.024 | 1 | 0.469 |
DAPK1 |
0.805 | 0.175 | -3 | 0.890 |
MEKK1 |
0.805 | -0.053 | 1 | 0.688 |
CDK18 |
0.805 | -0.030 | 1 | 0.422 |
CDK10 |
0.805 | 0.058 | 1 | 0.451 |
CDK9 |
0.805 | -0.044 | 1 | 0.488 |
PASK |
0.804 | 0.087 | -3 | 0.892 |
HPK1 |
0.804 | 0.300 | 1 | 0.768 |
NEK8 |
0.804 | 0.016 | 2 | 0.762 |
P38A |
0.803 | -0.038 | 1 | 0.523 |
DMPK1 |
0.803 | 0.266 | -3 | 0.888 |
JNK3 |
0.803 | -0.035 | 1 | 0.489 |
CDK2 |
0.803 | -0.051 | 1 | 0.517 |
ACVR2B |
0.803 | -0.090 | -2 | 0.832 |
PKG1 |
0.803 | 0.192 | -2 | 0.651 |
PERK |
0.803 | -0.113 | -2 | 0.877 |
CDK1 |
0.803 | -0.038 | 1 | 0.450 |
CDK12 |
0.803 | -0.037 | 1 | 0.463 |
GCK |
0.802 | 0.244 | 1 | 0.748 |
ROCK1 |
0.802 | 0.269 | -3 | 0.887 |
KHS1 |
0.802 | 0.326 | 1 | 0.777 |
TAO2 |
0.802 | 0.073 | 2 | 0.793 |
KHS2 |
0.801 | 0.320 | 1 | 0.785 |
CDK17 |
0.801 | -0.039 | 1 | 0.384 |
TNIK |
0.801 | 0.208 | 3 | 0.869 |
NEK11 |
0.801 | 0.038 | 1 | 0.714 |
MINK |
0.801 | 0.235 | 1 | 0.755 |
PINK1 |
0.801 | -0.139 | 1 | 0.606 |
PDK1 |
0.801 | 0.093 | 1 | 0.680 |
GRK2 |
0.800 | -0.074 | -2 | 0.791 |
CRIK |
0.800 | 0.262 | -3 | 0.866 |
HGK |
0.799 | 0.161 | 3 | 0.877 |
CDK16 |
0.799 | 0.002 | 1 | 0.396 |
TTBK1 |
0.799 | -0.072 | 2 | 0.602 |
P38G |
0.798 | -0.036 | 1 | 0.385 |
ERK2 |
0.798 | -0.067 | 1 | 0.508 |
LOK |
0.798 | 0.145 | -2 | 0.851 |
MST2 |
0.797 | 0.104 | 1 | 0.736 |
CAMKK1 |
0.797 | -0.054 | -2 | 0.807 |
RIPK2 |
0.797 | -0.015 | 1 | 0.667 |
P38B |
0.796 | -0.046 | 1 | 0.469 |
MST1 |
0.795 | 0.160 | 1 | 0.737 |
CAMKK2 |
0.795 | -0.038 | -2 | 0.808 |
LKB1 |
0.795 | -0.017 | -3 | 0.792 |
MEKK6 |
0.795 | 0.050 | 1 | 0.681 |
ERK1 |
0.795 | -0.063 | 1 | 0.467 |
BMPR1A |
0.795 | -0.047 | 1 | 0.572 |
PRP4 |
0.795 | -0.076 | -3 | 0.645 |
NEK1 |
0.794 | 0.066 | 1 | 0.682 |
TAK1 |
0.793 | 0.113 | 1 | 0.741 |
MAP3K15 |
0.793 | 0.024 | 1 | 0.676 |
EEF2K |
0.793 | 0.016 | 3 | 0.859 |
MOK |
0.792 | 0.137 | 1 | 0.519 |
CK1E |
0.792 | -0.071 | -3 | 0.471 |
MAK |
0.792 | 0.137 | -2 | 0.728 |
YSK1 |
0.792 | 0.078 | 2 | 0.735 |
CDK3 |
0.791 | -0.025 | 1 | 0.393 |
GAK |
0.791 | -0.058 | 1 | 0.603 |
STK33 |
0.791 | -0.050 | 2 | 0.585 |
LRRK2 |
0.790 | 0.010 | 2 | 0.786 |
MPSK1 |
0.789 | -0.082 | 1 | 0.562 |
SLK |
0.789 | 0.068 | -2 | 0.796 |
CK1G1 |
0.788 | -0.030 | -3 | 0.465 |
CDK4 |
0.788 | -0.003 | 1 | 0.449 |
GSK3B |
0.787 | -0.037 | 4 | 0.419 |
NEK3 |
0.787 | 0.009 | 1 | 0.663 |
CDK6 |
0.784 | -0.024 | 1 | 0.451 |
VRK1 |
0.783 | -0.109 | 2 | 0.816 |
CK2A2 |
0.783 | -0.027 | 1 | 0.484 |
CK1A2 |
0.782 | -0.063 | -3 | 0.431 |
GRK3 |
0.782 | -0.085 | -2 | 0.740 |
CK1D |
0.781 | -0.070 | -3 | 0.423 |
HASPIN |
0.781 | 0.053 | -1 | 0.701 |
GSK3A |
0.781 | -0.044 | 4 | 0.426 |
PLK2 |
0.781 | -0.049 | -3 | 0.706 |
ERK7 |
0.780 | -0.065 | 2 | 0.471 |
P38D |
0.780 | -0.055 | 1 | 0.408 |
MEK2 |
0.779 | -0.098 | 2 | 0.755 |
PBK |
0.779 | -0.035 | 1 | 0.535 |
BUB1 |
0.779 | 0.023 | -5 | 0.810 |
PDHK3_TYR |
0.776 | 0.054 | 4 | 0.891 |
TAO1 |
0.776 | 0.061 | 1 | 0.678 |
JNK1 |
0.776 | -0.065 | 1 | 0.439 |
MYO3A |
0.773 | 0.090 | 1 | 0.716 |
MYO3B |
0.773 | 0.043 | 2 | 0.745 |
TESK1_TYR |
0.773 | 0.032 | 3 | 0.910 |
CK2A1 |
0.771 | -0.048 | 1 | 0.470 |
TTK |
0.771 | -0.022 | -2 | 0.873 |
ASK1 |
0.770 | -0.020 | 1 | 0.665 |
OSR1 |
0.770 | -0.051 | 2 | 0.727 |
LIMK2_TYR |
0.769 | 0.059 | -3 | 0.875 |
MAP2K7_TYR |
0.768 | -0.045 | 2 | 0.817 |
BMPR2_TYR |
0.767 | 0.019 | -1 | 0.863 |
PINK1_TYR |
0.767 | -0.040 | 1 | 0.662 |
PDHK4_TYR |
0.767 | -0.031 | 2 | 0.836 |
MAP2K4_TYR |
0.767 | -0.055 | -1 | 0.851 |
RET |
0.767 | 0.076 | 1 | 0.694 |
PKMYT1_TYR |
0.766 | -0.079 | 3 | 0.887 |
MAP2K6_TYR |
0.766 | -0.053 | -1 | 0.867 |
EPHA6 |
0.764 | 0.023 | -1 | 0.837 |
PDHK1_TYR |
0.763 | -0.053 | -1 | 0.873 |
ALPHAK3 |
0.763 | -0.068 | -1 | 0.763 |
TYK2 |
0.763 | 0.033 | 1 | 0.701 |
BIKE |
0.762 | -0.080 | 1 | 0.479 |
MST1R |
0.761 | -0.003 | 3 | 0.836 |
NEK10_TYR |
0.761 | 0.106 | 1 | 0.641 |
ROS1 |
0.761 | 0.019 | 3 | 0.821 |
LIMK1_TYR |
0.760 | -0.091 | 2 | 0.808 |
DDR1 |
0.760 | -0.023 | 4 | 0.825 |
YANK3 |
0.759 | -0.057 | 2 | 0.397 |
JAK2 |
0.759 | 0.000 | 1 | 0.702 |
STLK3 |
0.759 | -0.064 | 1 | 0.676 |
JAK3 |
0.758 | -0.025 | 1 | 0.658 |
INSRR |
0.758 | 0.023 | 3 | 0.798 |
TNNI3K_TYR |
0.757 | 0.030 | 1 | 0.662 |
TYRO3 |
0.756 | -0.087 | 3 | 0.844 |
EPHB4 |
0.755 | -0.059 | -1 | 0.801 |
TNK1 |
0.754 | 0.023 | 3 | 0.826 |
CSF1R |
0.753 | -0.059 | 3 | 0.830 |
KDR |
0.752 | -0.014 | 3 | 0.802 |
FGFR2 |
0.751 | -0.065 | 3 | 0.830 |
PDGFRB |
0.751 | -0.087 | 3 | 0.847 |
JAK1 |
0.750 | 0.044 | 1 | 0.693 |
FLT3 |
0.750 | -0.046 | 3 | 0.838 |
ABL2 |
0.749 | -0.073 | -1 | 0.752 |
FGFR1 |
0.748 | -0.077 | 3 | 0.811 |
EPHB1 |
0.748 | -0.079 | 1 | 0.675 |
EPHA4 |
0.747 | -0.062 | 2 | 0.760 |
FGR |
0.747 | -0.117 | 1 | 0.637 |
EPHB3 |
0.747 | -0.072 | -1 | 0.782 |
TEK |
0.746 | -0.073 | 3 | 0.781 |
DDR2 |
0.746 | 0.022 | 3 | 0.773 |
PDGFRA |
0.746 | -0.086 | 3 | 0.843 |
EPHB2 |
0.745 | -0.067 | -1 | 0.781 |
AAK1 |
0.745 | -0.060 | 1 | 0.386 |
YES1 |
0.745 | -0.123 | -1 | 0.743 |
TNK2 |
0.745 | -0.085 | 3 | 0.759 |
KIT |
0.745 | -0.098 | 3 | 0.833 |
TXK |
0.744 | -0.082 | 1 | 0.606 |
ITK |
0.744 | -0.106 | -1 | 0.718 |
AXL |
0.743 | -0.098 | 3 | 0.811 |
FLT4 |
0.743 | -0.065 | 3 | 0.805 |
ABL1 |
0.743 | -0.108 | -1 | 0.734 |
FER |
0.743 | -0.183 | 1 | 0.667 |
HCK |
0.741 | -0.127 | -1 | 0.742 |
FLT1 |
0.741 | -0.067 | -1 | 0.825 |
SRMS |
0.741 | -0.141 | 1 | 0.662 |
ALK |
0.740 | -0.081 | 3 | 0.771 |
EPHA7 |
0.740 | -0.063 | 2 | 0.761 |
LTK |
0.740 | -0.077 | 3 | 0.791 |
ERBB2 |
0.739 | -0.088 | 1 | 0.640 |
LCK |
0.739 | -0.095 | -1 | 0.746 |
FGFR3 |
0.739 | -0.087 | 3 | 0.804 |
MERTK |
0.738 | -0.133 | 3 | 0.811 |
BMX |
0.738 | -0.093 | -1 | 0.642 |
CK1A |
0.738 | -0.116 | -3 | 0.331 |
EPHA3 |
0.738 | -0.091 | 2 | 0.735 |
MET |
0.737 | -0.132 | 3 | 0.805 |
TEC |
0.737 | -0.111 | -1 | 0.640 |
NTRK1 |
0.737 | -0.144 | -1 | 0.772 |
INSR |
0.737 | -0.101 | 3 | 0.769 |
BLK |
0.737 | -0.093 | -1 | 0.770 |
WEE1_TYR |
0.736 | -0.105 | -1 | 0.687 |
EPHA1 |
0.736 | -0.083 | 3 | 0.781 |
NTRK2 |
0.736 | -0.146 | 3 | 0.806 |
FRK |
0.735 | -0.084 | -1 | 0.775 |
BTK |
0.734 | -0.182 | -1 | 0.655 |
EPHA5 |
0.733 | -0.067 | 2 | 0.754 |
FYN |
0.729 | -0.090 | -1 | 0.721 |
EGFR |
0.729 | -0.097 | 1 | 0.552 |
PTK6 |
0.728 | -0.211 | -1 | 0.626 |
EPHA8 |
0.728 | -0.097 | -1 | 0.777 |
LYN |
0.727 | -0.125 | 3 | 0.778 |
NTRK3 |
0.727 | -0.159 | -1 | 0.725 |
CK1G3 |
0.726 | -0.066 | -3 | 0.285 |
CSK |
0.725 | -0.134 | 2 | 0.763 |
MATK |
0.725 | -0.140 | -1 | 0.703 |
YANK2 |
0.724 | -0.086 | 2 | 0.418 |
PTK2 |
0.723 | -0.051 | -1 | 0.776 |
PTK2B |
0.722 | -0.153 | -1 | 0.683 |
IGF1R |
0.722 | -0.104 | 3 | 0.722 |
FGFR4 |
0.722 | -0.102 | -1 | 0.731 |
MUSK |
0.722 | -0.129 | 1 | 0.528 |
EPHA2 |
0.720 | -0.089 | -1 | 0.747 |
SYK |
0.719 | -0.070 | -1 | 0.771 |
SRC |
0.718 | -0.159 | -1 | 0.709 |
ERBB4 |
0.717 | -0.080 | 1 | 0.550 |
CK1G2 |
0.699 | -0.097 | -3 | 0.380 |
ZAP70 |
0.697 | -0.103 | -1 | 0.698 |
FES |
0.696 | -0.196 | -1 | 0.610 |