Motif 770 (n=176)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYH1 | C15orf38-AP3S2 | S98 | ochoa | Arpin | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000256|ARBA:ARBA00025605}. |
| A1X283 | SH3PXD2B | S512 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| E7EWF7 | None | S95 | ochoa | Uncharacterized protein | None |
| J3QQQ9 | None | S32 | ochoa | KOW domain-containing protein | None |
| O00311 | CDC7 | S27 | ochoa | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O00311 | CDC7 | S216 | psp | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O14503 | BHLHE40 | S243 | psp | Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein) | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868). {ECO:0000269|PubMed:12397359, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|PubMed:15560782, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:28797635, ECO:0000269|PubMed:30012868}. |
| O14646 | CHD1 | S367 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14686 | KMT2D | S2309 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S3239 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14896 | IRF6 | S47 | ochoa | Interferon regulatory factor 6 (IRF-6) | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}. |
| O60356 | NUPR1 | S58 | ochoa | Nuclear protein 1 (Candidate of metastasis 1) (Protein p8) | Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}. |
| O60427 | FADS1 | S87 | ochoa | Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1) | [Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). {ECO:0000250|UniProtKB:Q920L1, ECO:0000250|UniProtKB:Q920R3, ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175}.; FUNCTION: [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity. {ECO:0000250|UniProtKB:A4UVI1}. |
| O75410 | TACC1 | S316 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75563 | SKAP2 | S131 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| P00533 | EGFR | S720 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04626 | ERBB2 | S728 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P09651 | HNRNPA1 | S142 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P10809 | HSPD1 | S70 | ochoa|psp | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11055 | MYH3 | S739 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11137 | MAP2 | S736 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11142 | HSPA8 | S329 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11142 | HSPA8 | S538 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12882 | MYH1 | S742 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S738 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13535 | MYH8 | S741 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13631 | RARG | S176 | ochoa | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}. |
| P16615 | ATP2A2 | S170 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P19338 | NCL | S494 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P21127 | CDK11B | S752 | ochoa|psp | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P21860 | ERBB3 | S717 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P22102 | GART | S434 | ochoa | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| P22626 | HNRNPA2B1 | S149 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P24941 | CDK2 | S46 | psp | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}. |
| P25054 | APC | S1042 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26640 | VARS1 | S301 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P28340 | POLD1 | S788 | ochoa | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24022480, PubMed:24035200, PubMed:31449058). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24022480, PubMed:24035200). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites (PubMed:19074196, PubMed:24191025). {ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24022480, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:31449058}. |
| P30307 | CDC25C | S214 | ochoa|psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P35611 | ADD1 | S64 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P35612 | ADD2 | S60 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P40925 | MDH1 | S217 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P43004 | SLC1A2 | S21 | ochoa | Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}. |
| P43243 | MATR3 | S598 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P45974 | USP5 | S159 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46013 | MKI67 | S235 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48059 | LIMS1 | S265 | ochoa | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. {ECO:0000269|PubMed:30367047}. |
| P49116 | NR2C2 | S351 | ochoa | Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
| P49757 | NUMB | S295 | ochoa|psp | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P50851 | LRBA | S1051 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P60484 | PTEN | S294 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P60709 | ACTB | S265 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61254 | RPL26 | S32 | ochoa | Large ribosomal subunit protein uL24 (60S ribosomal protein L26) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:26100019, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:26100019, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:26100019}. |
| P62491 | RAB11A | S190 | ochoa | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| P63261 | ACTG1 | S265 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| Q00653 | NFKB2 | S277 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q05086 | UBE3A | S93 | ochoa | Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990, PubMed:30020076). Several substrates have been identified including the BMAL1, ARC, LAMTOR1, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990, PubMed:30020076). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Required for synaptic remodeling in neurons by mediating ubiquitination and degradation of LAMTOR1, thereby limiting mTORC1 signaling and activity-dependent synaptic remodeling (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:O08759, ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0000269|PubMed:19325566, ECO:0000269|PubMed:19591933, ECO:0000269|PubMed:22645313, ECO:0000269|PubMed:24273172, ECO:0000269|PubMed:24728990, ECO:0000269|PubMed:30020076}.; FUNCTION: (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. {ECO:0000269|PubMed:8380895}. |
| Q08357 | SLC20A2 | S253 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q09666 | AHNAK | S613 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4960 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12816 | TRO | S155 | ochoa | Trophinin (MAGE-D3 antigen) | Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. |
| Q13352 | ITGB3BP | S46 | psp | Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) | Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}. |
| Q13546 | RIPK1 | S166 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q14008 | CKAP5 | S1149 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14134 | TRIM29 | S256 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14203 | DCTN1 | S1182 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14289 | PTK2B | S839 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14676 | MDC1 | S793 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14680 | MELK | S431 | ochoa|psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q15139 | PRKD1 | S421 | psp | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15303 | ERBB4 | S726 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q15361 | TTF1 | S621 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15596 | NCOA2 | S736 | ochoa|psp | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16623 | STX1A | S64 | ochoa | Syntaxin-1A (Neuron-specific antigen HPC-1) | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}. |
| Q29RF7 | PDS5A | S1305 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2KHR3 | QSER1 | S893 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2NKX8 | ERCC6L | S1173 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q32P51 | HNRNPA1L2 | S142 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q460N5 | PARP14 | S1396 | ochoa | Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:18851833, PubMed:25043379, PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). {ECO:0000269|PubMed:16061477, ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27796300, ECO:0000305|PubMed:29858569}. |
| Q504Q3 | PAN2 | S474 | ochoa | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}. |
| Q5BJF6 | ODF2 | S106 | ochoa | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}. |
| Q5BKX6 | SLC45A4 | S732 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5FWF5 | ESCO1 | S423 | ochoa | N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}. |
| Q5JTV8 | TOR1AIP1 | S315 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5MIZ7 | PPP4R3B | S155 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. |
| Q5R372 | RABGAP1L | S292 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5T0N5 | FNBP1L | S300 | ochoa | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}. |
| Q5T5P2 | KIAA1217 | S1292 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5UIP0 | RIF1 | S790 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1666 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZK9 | CARMIL1 | S972 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q5VZK9 | CARMIL1 | S1165 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q6NW34 | NEPRO | S265 | ochoa | Nucleolus and neural progenitor protein | May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. {ECO:0000250|UniProtKB:Q8R2U2}. |
| Q6NYC8 | PPP1R18 | S213 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P1L8 | MRPL14 | S49 | ochoa | Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32) | Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). {ECO:0000305|PubMed:22829778}. |
| Q6P5Q4 | LMOD2 | S186 | ochoa | Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) | Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). {ECO:0000250|UniProtKB:Q3UHZ5, ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:25250574, ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:26417072}. |
| Q6UX04 | CWC27 | S299 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q6UXG2 | ELAPOR1 | S960 | ochoa | Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) | May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}. |
| Q6VMQ6 | ATF7IP | S293 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6VY07 | PACS1 | S495 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZRV2 | FAM83H | S1147 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q709C8 | VPS13C | S839 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q7LBC6 | KDM3B | S1284 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z6K5 | ARPIN | S98 | ochoa | Arpin (Arp2/3 inhibition protein) | Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}. |
| Q86SQ0 | PHLDB2 | S31 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86W50 | METTL16 | S329 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q86W56 | PARG | S137 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q8IVF2 | AHNAK2 | S820 | ochoa | Protein AHNAK2 | None |
| Q8IWS0 | PHF6 | S138 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IY57 | YAF2 | S112 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8NC60 | NOA1 | S411 | ochoa | Nitric oxide-associated protein 1 | Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. {ECO:0000269|PubMed:19103604}. |
| Q8NCF5 | NFATC2IP | S338 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NDV7 | TNRC6A | S678 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NEY1 | NAV1 | S1236 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFT8 | DNER | S714 | ochoa | Delta and Notch-like epidermal growth factor-related receptor | Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}. |
| Q8NFZ5 | TNIP2 | S186 | ochoa | TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein) | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}. |
| Q8TDR0 | TRAF3IP1 | S557 | ochoa | TRAF3-interacting protein 1 (Interleukin-13 receptor alpha 1-binding protein 1) (Intraflagellar transport protein 54 homolog) (Microtubule-interacting protein associated with TRAF3) (MIP-T3) | Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q149C2, ECO:0000269|PubMed:10791955, ECO:0000269|PubMed:12812986, ECO:0000269|PubMed:12935900, ECO:0000269|PubMed:26487268}. |
| Q8TF72 | SHROOM3 | S1497 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUJ0 | STYX | S184 | ochoa | Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein) | Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q60969, ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}. |
| Q8WUY9 | DEPDC1B | S445 | ochoa | DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) | None |
| Q92547 | TOPBP1 | S888 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92585 | MAML1 | S120 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92598 | HSPH1 | S510 | ochoa | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q92750 | TAF4B | S252 | ochoa | Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) | Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}. |
| Q969V6 | MRTFA | S511 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96IQ7 | VSIG2 | S303 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96JM2 | ZNF462 | S1747 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96JM3 | CHAMP1 | S572 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96ME7 | ZNF512 | S537 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
| Q96PZ0 | PUS7 | S23 | ochoa | Pseudouridylate synthase 7 homolog (EC 5.4.99.-) | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}. |
| Q96RL1 | UIMC1 | S44 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RT1 | ERBIN | S832 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RU3 | FNBP1 | S301 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q96S38 | RPS6KC1 | S872 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96T58 | SPEN | S2366 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99471 | PFDN5 | S56 | ochoa | Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. {ECO:0000269|PubMed:9630229}. |
| Q99490 | AGAP2 | S818 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99614 | TTC1 | S90 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q99758 | ABCA3 | S1434 | ochoa | Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form] | Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:27177387, PubMed:28887056, PubMed:31473345). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:25817392, PubMed:26903515, PubMed:27177387). {ECO:0000269|PubMed:16959783, ECO:0000269|PubMed:17574245, ECO:0000269|PubMed:25817392, ECO:0000269|PubMed:26903515, ECO:0000269|PubMed:27177387, ECO:0000269|PubMed:28887056, ECO:0000269|PubMed:31473345}. |
| Q9BQI6 | SLF1 | S919 | ochoa | SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565, PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q9BVI0 | PHF20 | S159 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BW71 | HIRIP3 | S305 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BX66 | SORBS1 | S328 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BY89 | KIAA1671 | S1506 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZ95 | NSD3 | S498 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9BZL6 | PRKD2 | S396 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9H6S3 | EPS8L2 | S442 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H792 | PEAK1 | S662 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HC77 | CPAP | S859 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCK8 | CHD8 | S562 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCM7 | FBRSL1 | S830 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NP79 | VTA1 | S281 | ochoa | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269|PubMed:15644320}. |
| Q9NPC7 | MYNN | S282 | ochoa | Myoneurin (Zinc finger and BTB domain-containing protein 31) | None |
| Q9NQ75 | CASS4 | S555 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NYT0 | PLEK2 | S116 | ochoa | Pleckstrin-2 | May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. |
| Q9UBT2 | UBA2 | S297 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
| Q9UEY8 | ADD3 | S64 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UGU5 | HMGXB4 | S203 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UK61 | TASOR | S1210 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKE5 | TNIK | S951 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKS6 | PACSIN3 | S178 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9UKX2 | MYH2 | S744 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULD5 | ZNF777 | S143 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9UNX3 | RPL26L1 | S32 | ochoa | Ribosomal protein uL24-like (60S ribosomal protein L26-like 1) (Large ribosomal subunit protein uL24-like 1) | None |
| Q9UQ88 | CDK11A | S740 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2Q0 | ATP8A1 | S29 | ochoa | Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity). {ECO:0000250|UniProtKB:P70704, ECO:0000269|PubMed:31416931}. |
| Q9Y2X9 | ZNF281 | S642 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y4D2 | DAGLA | S952 | ochoa | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}. |
| Q9Y623 | MYH4 | S742 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6D6 | ARFGEF1 | S52 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6R0 | NUMBL | S324 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| O14618 | CCS | S197 | Sugiyama | Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) | Delivers copper to copper zinc superoxide dismutase (SOD1). |
| Q14257 | RCN2 | S37 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| P17844 | DDX5 | Y418 | Sugiyama | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P31939 | ATIC | S370 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| O95747 | OXSR1 | S498 | Sugiyama | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| Q13873 | BMPR2 | S185 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.543976e-07 | 6.811 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.536231e-07 | 6.814 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.113204e-07 | 6.675 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.283648e-07 | 6.368 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 5.161818e-07 | 6.287 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.161818e-07 | 6.287 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 8.722875e-06 | 5.059 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 8.173406e-06 | 5.088 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.089446e-05 | 4.963 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.145603e-05 | 4.502 |
| R-HSA-8848021 | Signaling by PTK6 | 4.121523e-05 | 4.385 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.121523e-05 | 4.385 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.274498e-05 | 4.202 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.677080e-04 | 3.775 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 4.068042e-04 | 3.391 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.617460e-04 | 3.179 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.049111e-04 | 3.152 |
| R-HSA-380287 | Centrosome maturation | 7.502238e-04 | 3.125 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 1.247643e-03 | 2.904 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 1.247643e-03 | 2.904 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 1.247643e-03 | 2.904 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 1.247643e-03 | 2.904 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 1.247643e-03 | 2.904 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 1.247643e-03 | 2.904 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 1.247643e-03 | 2.904 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 1.247643e-03 | 2.904 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 1.247643e-03 | 2.904 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 1.247643e-03 | 2.904 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 1.247643e-03 | 2.904 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.126881e-03 | 2.948 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.578524e-04 | 3.067 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.553597e-03 | 2.809 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.579630e-03 | 2.801 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.945671e-03 | 2.711 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 2.760640e-03 | 2.559 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 2.760640e-03 | 2.559 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 2.578645e-03 | 2.589 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.576196e-03 | 2.589 |
| R-HSA-1640170 | Cell Cycle | 2.651984e-03 | 2.576 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.325462e-03 | 2.478 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.256708e-03 | 2.487 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.325462e-03 | 2.478 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.257364e-03 | 2.487 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.508291e-03 | 2.455 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.901361e-03 | 2.310 |
| R-HSA-69275 | G2/M Transition | 5.117719e-03 | 2.291 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 5.728272e-03 | 2.242 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.414793e-03 | 2.266 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 6.305613e-03 | 2.200 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 6.057948e-03 | 2.218 |
| R-HSA-8939211 | ESR-mediated signaling | 6.095188e-03 | 2.215 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.302767e-03 | 2.137 |
| R-HSA-9620244 | Long-term potentiation | 7.561249e-03 | 2.121 |
| R-HSA-196025 | Formation of annular gap junctions | 8.900207e-03 | 2.051 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.178125e-03 | 2.037 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.265487e-03 | 2.033 |
| R-HSA-190873 | Gap junction degradation | 1.050437e-02 | 1.979 |
| R-HSA-69481 | G2/M Checkpoints | 1.021065e-02 | 1.991 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.061732e-02 | 1.974 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.116627e-02 | 1.952 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.122373e-02 | 1.950 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.265025e-02 | 1.898 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.222617e-02 | 1.913 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.342038e-02 | 1.872 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.342038e-02 | 1.872 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.398638e-02 | 1.854 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.538250e-02 | 1.813 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 1.495214e-02 | 1.825 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.595473e-02 | 1.797 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 1.600997e-02 | 1.796 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.806574e-02 | 1.743 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.982664e-02 | 1.703 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.806574e-02 | 1.743 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.945432e-02 | 1.711 |
| R-HSA-68877 | Mitotic Prometaphase | 1.974465e-02 | 1.705 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.678584e-02 | 1.775 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.892691e-02 | 1.723 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.918471e-02 | 1.717 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.692464e-02 | 1.771 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.837266e-02 | 1.736 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.008868e-02 | 1.697 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.049476e-02 | 1.688 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.086496e-02 | 1.681 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.146627e-02 | 1.668 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.152403e-02 | 1.667 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.485244e-02 | 1.605 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.313470e-02 | 1.636 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.248991e-02 | 1.648 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.338564e-02 | 1.631 |
| R-HSA-4839726 | Chromatin organization | 2.287213e-02 | 1.641 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.514124e-02 | 1.600 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.514124e-02 | 1.600 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.514124e-02 | 1.600 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.514124e-02 | 1.600 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.514124e-02 | 1.600 |
| R-HSA-9659379 | Sensory processing of sound | 2.592044e-02 | 1.586 |
| R-HSA-373760 | L1CAM interactions | 2.627252e-02 | 1.580 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.784613e-02 | 1.555 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.089088e-02 | 1.510 |
| R-HSA-5693538 | Homology Directed Repair | 2.779764e-02 | 1.556 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.986414e-02 | 1.525 |
| R-HSA-212436 | Generic Transcription Pathway | 2.766424e-02 | 1.558 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.185311e-02 | 1.497 |
| R-HSA-437239 | Recycling pathway of L1 | 3.389273e-02 | 1.470 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.412444e-02 | 1.467 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.545168e-02 | 1.450 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.638561e-02 | 1.439 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 3.747496e-02 | 1.426 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 3.747496e-02 | 1.426 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.116192e-02 | 1.386 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.356722e-02 | 1.361 |
| R-HSA-162582 | Signal Transduction | 4.508621e-02 | 1.346 |
| R-HSA-74160 | Gene expression (Transcription) | 4.572947e-02 | 1.340 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.922035e-02 | 1.308 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.699801e-02 | 1.328 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 5.013275e-02 | 1.300 |
| R-HSA-5617833 | Cilium Assembly | 5.243919e-02 | 1.280 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.334072e-02 | 1.273 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 6.167848e-02 | 1.210 |
| R-HSA-5683678 | Defective ABCA3 causes SMDP3 | 6.167848e-02 | 1.210 |
| R-HSA-5688399 | Defective ABCA3 causes SMDP3 | 6.167848e-02 | 1.210 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 6.167848e-02 | 1.210 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 7.355214e-02 | 1.133 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 7.355214e-02 | 1.133 |
| R-HSA-68911 | G2 Phase | 8.527628e-02 | 1.069 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 9.685276e-02 | 1.014 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 9.685276e-02 | 1.014 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.685276e-02 | 1.014 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 9.685276e-02 | 1.014 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.082834e-01 | 0.965 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.195701e-01 | 0.922 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.195701e-01 | 0.922 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.195701e-01 | 0.922 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.307147e-01 | 0.884 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.307147e-01 | 0.884 |
| R-HSA-9613354 | Lipophagy | 1.417188e-01 | 0.849 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.417188e-01 | 0.849 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.525843e-01 | 0.816 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.633130e-01 | 0.787 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.633130e-01 | 0.787 |
| R-HSA-4839744 | Signaling by APC mutants | 1.633130e-01 | 0.787 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.633130e-01 | 0.787 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.633130e-01 | 0.787 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.633130e-01 | 0.787 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.739064e-01 | 0.760 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.843664e-01 | 0.734 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.843664e-01 | 0.734 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.843664e-01 | 0.734 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.843664e-01 | 0.734 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.946945e-01 | 0.711 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.048925e-01 | 0.688 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.048925e-01 | 0.688 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.149620e-01 | 0.668 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.149620e-01 | 0.668 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.149620e-01 | 0.668 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.149620e-01 | 0.668 |
| R-HSA-390522 | Striated Muscle Contraction | 9.282629e-02 | 1.032 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 9.674376e-02 | 1.014 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.444154e-01 | 0.612 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.539867e-01 | 0.595 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.634374e-01 | 0.579 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.727689e-01 | 0.564 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.727689e-01 | 0.564 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.819828e-01 | 0.550 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.910805e-01 | 0.536 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.192815e-01 | 0.923 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.192815e-01 | 0.923 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.375350e-01 | 0.862 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.991685e-01 | 0.524 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.819828e-01 | 0.550 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.819828e-01 | 0.550 |
| R-HSA-6807070 | PTEN Regulation | 1.394651e-01 | 0.856 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.444154e-01 | 0.612 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.444154e-01 | 0.612 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.819828e-01 | 0.550 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.048925e-01 | 0.688 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.148812e-01 | 0.668 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.149620e-01 | 0.668 |
| R-HSA-180292 | GAB1 signalosome | 2.539867e-01 | 0.595 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.382058e-01 | 0.623 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.307147e-01 | 0.884 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.000634e-01 | 0.523 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.843664e-01 | 0.734 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.727689e-01 | 0.564 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.754064e-01 | 0.756 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.727689e-01 | 0.564 |
| R-HSA-72172 | mRNA Splicing | 1.591680e-01 | 0.798 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 8.527628e-02 | 1.069 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.843664e-01 | 0.734 |
| R-HSA-68962 | Activation of the pre-replicative complex | 7.765660e-02 | 1.110 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.048925e-01 | 0.688 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.137019e-02 | 1.090 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.087670e-01 | 0.964 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.296056e-01 | 0.887 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.338787e-01 | 0.873 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.819828e-01 | 0.550 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.517475e-02 | 1.021 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 7.355214e-02 | 1.133 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.946945e-01 | 0.711 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 8.513762e-02 | 1.070 |
| R-HSA-3371568 | Attenuation phase | 1.211600e-01 | 0.917 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.917955e-01 | 0.717 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.102410e-01 | 0.677 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 8.137019e-02 | 1.090 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.296056e-01 | 0.887 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.512722e-01 | 0.820 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.512722e-01 | 0.820 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.512722e-01 | 0.820 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.691792e-01 | 0.772 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.663473e-01 | 0.575 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.249046e-01 | 0.648 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.307147e-01 | 0.884 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.525843e-01 | 0.816 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.525843e-01 | 0.816 |
| R-HSA-429947 | Deadenylation of mRNA | 5.661959e-02 | 1.247 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.739064e-01 | 0.760 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.739064e-01 | 0.760 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.739064e-01 | 0.760 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 6.685889e-02 | 1.175 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.946945e-01 | 0.711 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.946945e-01 | 0.711 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.539867e-01 | 0.595 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.000634e-01 | 0.523 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.735865e-01 | 0.760 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.176910e-01 | 0.498 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.176910e-01 | 0.498 |
| R-HSA-9839394 | TGFBR3 expression | 3.263384e-01 | 0.486 |
| R-HSA-73886 | Chromosome Maintenance | 9.517475e-02 | 1.021 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.754064e-01 | 0.756 |
| R-HSA-69242 | S Phase | 1.629952e-01 | 0.788 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.475759e-01 | 0.606 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.539867e-01 | 0.595 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.195701e-01 | 0.922 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.347219e-01 | 0.629 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.512722e-01 | 0.820 |
| R-HSA-157579 | Telomere Maintenance | 1.599647e-01 | 0.796 |
| R-HSA-157118 | Signaling by NOTCH | 1.166531e-01 | 0.933 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.727689e-01 | 0.564 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 6.338089e-02 | 1.198 |
| R-HSA-3371556 | Cellular response to heat stress | 2.473848e-01 | 0.607 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.500831e-01 | 0.824 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.522661e-01 | 0.598 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.000634e-01 | 0.523 |
| R-HSA-180786 | Extension of Telomeres | 2.102410e-01 | 0.677 |
| R-HSA-1980143 | Signaling by NOTCH1 | 9.301395e-02 | 1.031 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 6.338089e-02 | 1.198 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.033117e-01 | 0.692 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.522661e-01 | 0.598 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.139874e-01 | 0.670 |
| R-HSA-112310 | Neurotransmitter release cycle | 1.333350e-01 | 0.875 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.307147e-01 | 0.884 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.307147e-01 | 0.884 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.307147e-01 | 0.884 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.525843e-01 | 0.816 |
| R-HSA-426048 | Arachidonate production from DAG | 1.525843e-01 | 0.816 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.739064e-01 | 0.760 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.539867e-01 | 0.595 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.634374e-01 | 0.579 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.819828e-01 | 0.550 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.176910e-01 | 0.498 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.263384e-01 | 0.486 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.263384e-01 | 0.486 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 1.253655e-01 | 0.902 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.454502e-01 | 0.837 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.934043e-01 | 0.533 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 9.685276e-02 | 1.014 |
| R-HSA-69091 | Polymerase switching | 1.843664e-01 | 0.734 |
| R-HSA-69109 | Leading Strand Synthesis | 1.843664e-01 | 0.734 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.249046e-01 | 0.648 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.271207e-01 | 0.485 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.264295e-01 | 0.486 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.335276e-01 | 0.632 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.263384e-01 | 0.486 |
| R-HSA-9664407 | Parasite infection | 3.229667e-01 | 0.491 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.229667e-01 | 0.491 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.229667e-01 | 0.491 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.041663e-01 | 0.690 |
| R-HSA-8956320 | Nucleotide biosynthesis | 1.826570e-01 | 0.738 |
| R-HSA-5683826 | Surfactant metabolism | 1.425182e-01 | 0.846 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.041663e-01 | 0.690 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.880477e-01 | 0.726 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 8.527628e-02 | 1.069 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 8.527628e-02 | 1.069 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 9.685276e-02 | 1.014 |
| R-HSA-447041 | CHL1 interactions | 1.195701e-01 | 0.922 |
| R-HSA-448706 | Interleukin-1 processing | 1.417188e-01 | 0.849 |
| R-HSA-5682910 | LGI-ADAM interactions | 1.633130e-01 | 0.787 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.739064e-01 | 0.760 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.946945e-01 | 0.711 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 7.765660e-02 | 1.110 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.048925e-01 | 0.688 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.149620e-01 | 0.668 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.149620e-01 | 0.668 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.444154e-01 | 0.612 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.856774e-02 | 1.105 |
| R-HSA-190828 | Gap junction trafficking | 1.425182e-01 | 0.846 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.819828e-01 | 0.550 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.102410e-01 | 0.677 |
| R-HSA-3214847 | HATs acetylate histones | 1.660905e-01 | 0.780 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.009166e-01 | 0.697 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 6.338089e-02 | 1.198 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 2.148812e-01 | 0.668 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.337108e-02 | 1.198 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.009931e-01 | 0.697 |
| R-HSA-73894 | DNA Repair | 1.144430e-01 | 0.941 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.253655e-01 | 0.902 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 8.137019e-02 | 1.090 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.444154e-01 | 0.612 |
| R-HSA-68886 | M Phase | 2.554538e-01 | 0.593 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 9.805694e-02 | 1.009 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 8.527628e-02 | 1.069 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.048925e-01 | 0.688 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.347219e-01 | 0.629 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.645938e-01 | 0.784 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.263384e-01 | 0.486 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.089331e-01 | 0.510 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 1.843664e-01 | 0.734 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 6.685889e-02 | 1.175 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.048925e-01 | 0.688 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.048925e-01 | 0.688 |
| R-HSA-5688426 | Deubiquitination | 6.369778e-02 | 1.196 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.645938e-01 | 0.784 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.645938e-01 | 0.784 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.565991e-02 | 1.067 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.000634e-01 | 0.523 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.634374e-01 | 0.579 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.754064e-01 | 0.756 |
| R-HSA-422475 | Axon guidance | 1.874647e-01 | 0.727 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2.249046e-01 | 0.648 |
| R-HSA-3214842 | HDMs demethylate histones | 3.263384e-01 | 0.486 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.215843e-02 | 1.085 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.220462e-01 | 0.913 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 8.895696e-02 | 1.051 |
| R-HSA-9675108 | Nervous system development | 2.411099e-01 | 0.618 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.946945e-01 | 0.711 |
| R-HSA-8876725 | Protein methylation | 2.149620e-01 | 0.668 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.444154e-01 | 0.612 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.556886e-01 | 0.808 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.633130e-01 | 0.787 |
| R-HSA-1500931 | Cell-Cell communication | 2.583234e-01 | 0.588 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.417188e-01 | 0.849 |
| R-HSA-9842663 | Signaling by LTK | 1.843664e-01 | 0.734 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.007075e-01 | 0.997 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.444154e-01 | 0.612 |
| R-HSA-2559583 | Cellular Senescence | 2.489529e-01 | 0.604 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.975322e-02 | 1.156 |
| R-HSA-445144 | Signal transduction by L1 | 2.727689e-01 | 0.564 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 3.089331e-01 | 0.510 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.176910e-01 | 0.498 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.176910e-01 | 0.498 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.288551e-01 | 0.640 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.733038e-01 | 0.563 |
| R-HSA-9909396 | Circadian clock | 2.918480e-01 | 0.535 |
| R-HSA-2262752 | Cellular responses to stress | 1.741715e-01 | 0.759 |
| R-HSA-877300 | Interferon gamma signaling | 1.903977e-01 | 0.720 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.089331e-01 | 0.510 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.475759e-01 | 0.606 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.678660e-01 | 0.775 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.362125e-01 | 0.866 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.167127e-01 | 0.499 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.929591e-01 | 0.715 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.634374e-01 | 0.579 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.047159e-01 | 0.980 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.539867e-01 | 0.595 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.851183e-01 | 0.545 |
| R-HSA-5358508 | Mismatch Repair | 2.539867e-01 | 0.595 |
| R-HSA-449836 | Other interleukin signaling | 2.634374e-01 | 0.579 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.169907e-01 | 0.932 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.634374e-01 | 0.579 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 2.148812e-01 | 0.668 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 8.513762e-02 | 1.070 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.634374e-01 | 0.579 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.272350e-01 | 0.644 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.125811e-01 | 0.505 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.946945e-01 | 0.711 |
| R-HSA-194138 | Signaling by VEGF | 2.643812e-01 | 0.578 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.444154e-01 | 0.612 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.048925e-01 | 0.688 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.425182e-01 | 0.846 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.352847e-01 | 0.628 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.634374e-01 | 0.579 |
| R-HSA-75153 | Apoptotic execution phase | 1.512722e-01 | 0.820 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.382058e-01 | 0.623 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.248343e-01 | 0.904 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 3.000634e-01 | 0.523 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.394651e-01 | 0.856 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.898055e-01 | 0.538 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.754064e-01 | 0.756 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.317533e-01 | 0.479 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.330467e-01 | 0.477 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.348767e-01 | 0.475 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.348767e-01 | 0.475 |
| R-HSA-3295583 | TRP channels | 3.348767e-01 | 0.475 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.348767e-01 | 0.475 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.348767e-01 | 0.475 |
| R-HSA-2046105 | Linoleic acid (LA) metabolism | 3.348767e-01 | 0.475 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.348767e-01 | 0.475 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.348767e-01 | 0.475 |
| R-HSA-397014 | Muscle contraction | 3.422686e-01 | 0.466 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.433073e-01 | 0.464 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.433073e-01 | 0.464 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.433073e-01 | 0.464 |
| R-HSA-201451 | Signaling by BMP | 3.433073e-01 | 0.464 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.433073e-01 | 0.464 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.433073e-01 | 0.464 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.433073e-01 | 0.464 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.433073e-01 | 0.464 |
| R-HSA-264876 | Insulin processing | 3.433073e-01 | 0.464 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.451405e-01 | 0.462 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.455955e-01 | 0.461 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.455955e-01 | 0.461 |
| R-HSA-199991 | Membrane Trafficking | 3.478333e-01 | 0.459 |
| R-HSA-156902 | Peptide chain elongation | 3.501894e-01 | 0.456 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.501894e-01 | 0.456 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.516316e-01 | 0.454 |
| R-HSA-622312 | Inflammasomes | 3.516316e-01 | 0.454 |
| R-HSA-68882 | Mitotic Anaphase | 3.537592e-01 | 0.451 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.541073e-01 | 0.451 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.566325e-01 | 0.448 |
| R-HSA-73884 | Base Excision Repair | 3.593441e-01 | 0.444 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.598508e-01 | 0.444 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.598508e-01 | 0.444 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.598508e-01 | 0.444 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.598508e-01 | 0.444 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.598508e-01 | 0.444 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.598508e-01 | 0.444 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.639040e-01 | 0.439 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.639040e-01 | 0.439 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.679664e-01 | 0.434 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.679664e-01 | 0.434 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.679664e-01 | 0.434 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.684516e-01 | 0.434 |
| R-HSA-69306 | DNA Replication | 3.713442e-01 | 0.430 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.729866e-01 | 0.428 |
| R-HSA-391251 | Protein folding | 3.729866e-01 | 0.428 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.729866e-01 | 0.428 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.747824e-01 | 0.426 |
| R-HSA-182971 | EGFR downregulation | 3.759796e-01 | 0.425 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.759796e-01 | 0.425 |
| R-HSA-1989781 | PPARA activates gene expression | 3.782170e-01 | 0.422 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.838917e-01 | 0.416 |
| R-HSA-69190 | DNA strand elongation | 3.838917e-01 | 0.416 |
| R-HSA-1538133 | G0 and Early G1 | 3.838917e-01 | 0.416 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.850744e-01 | 0.414 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.865117e-01 | 0.413 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.865117e-01 | 0.413 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.909922e-01 | 0.408 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.909922e-01 | 0.408 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.909922e-01 | 0.408 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.917039e-01 | 0.407 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.917039e-01 | 0.407 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.917039e-01 | 0.407 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.917039e-01 | 0.407 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.917039e-01 | 0.407 |
| R-HSA-159418 | Recycling of bile acids and salts | 3.917039e-01 | 0.407 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.917039e-01 | 0.407 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.994176e-01 | 0.399 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.994176e-01 | 0.399 |
| R-HSA-109581 | Apoptosis | 4.021391e-01 | 0.396 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.043448e-01 | 0.393 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.043448e-01 | 0.393 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.043448e-01 | 0.393 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.070339e-01 | 0.390 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.070339e-01 | 0.390 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.070339e-01 | 0.390 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.070339e-01 | 0.390 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.070339e-01 | 0.390 |
| R-HSA-5365859 | RA biosynthesis pathway | 4.070339e-01 | 0.390 |
| R-HSA-8953854 | Metabolism of RNA | 4.081117e-01 | 0.389 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.145541e-01 | 0.382 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.145541e-01 | 0.382 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.175573e-01 | 0.379 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.175573e-01 | 0.379 |
| R-HSA-1483255 | PI Metabolism | 4.219289e-01 | 0.375 |
| R-HSA-8853659 | RET signaling | 4.219794e-01 | 0.375 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.219794e-01 | 0.375 |
| R-HSA-3371511 | HSF1 activation | 4.219794e-01 | 0.375 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.219794e-01 | 0.375 |
| R-HSA-192823 | Viral mRNA Translation | 4.262837e-01 | 0.370 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.306214e-01 | 0.366 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.325020e-01 | 0.364 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.349418e-01 | 0.362 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.349418e-01 | 0.362 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.365499e-01 | 0.360 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.365499e-01 | 0.360 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 4.365499e-01 | 0.360 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.365499e-01 | 0.360 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.392447e-01 | 0.357 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.425025e-01 | 0.354 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.425025e-01 | 0.354 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.425025e-01 | 0.354 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.435297e-01 | 0.353 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.436976e-01 | 0.353 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.436976e-01 | 0.353 |
| R-HSA-69541 | Stabilization of p53 | 4.436976e-01 | 0.353 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.436976e-01 | 0.353 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.458210e-01 | 0.351 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.477966e-01 | 0.349 |
| R-HSA-69239 | Synthesis of DNA | 4.477966e-01 | 0.349 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.477966e-01 | 0.349 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.477966e-01 | 0.349 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.491319e-01 | 0.348 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.507550e-01 | 0.346 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.507550e-01 | 0.346 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.507550e-01 | 0.346 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.507550e-01 | 0.346 |
| R-HSA-5260271 | Diseases of Immune System | 4.507550e-01 | 0.346 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.507550e-01 | 0.346 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.520453e-01 | 0.345 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.520453e-01 | 0.345 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.520453e-01 | 0.345 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.562754e-01 | 0.341 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.562754e-01 | 0.341 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.577233e-01 | 0.339 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.577233e-01 | 0.339 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.577233e-01 | 0.339 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.577233e-01 | 0.339 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.577233e-01 | 0.339 |
| R-HSA-167161 | HIV Transcription Initiation | 4.646036e-01 | 0.333 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.646036e-01 | 0.333 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.646036e-01 | 0.333 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.646036e-01 | 0.333 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.646036e-01 | 0.333 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.646036e-01 | 0.333 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.688526e-01 | 0.329 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.688526e-01 | 0.329 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.713970e-01 | 0.327 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.713970e-01 | 0.327 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.730067e-01 | 0.325 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.753214e-01 | 0.323 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.781047e-01 | 0.320 |
| R-HSA-8854214 | TBC/RABGAPs | 4.781047e-01 | 0.320 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.847276e-01 | 0.315 |
| R-HSA-69236 | G1 Phase | 4.847276e-01 | 0.315 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.847276e-01 | 0.315 |
| R-HSA-373752 | Netrin-1 signaling | 4.847276e-01 | 0.315 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.853511e-01 | 0.314 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.876806e-01 | 0.312 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.894261e-01 | 0.310 |
| R-HSA-774815 | Nucleosome assembly | 4.912669e-01 | 0.309 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.912669e-01 | 0.309 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.912669e-01 | 0.309 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.912669e-01 | 0.309 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.912669e-01 | 0.309 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.912669e-01 | 0.309 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.913996e-01 | 0.309 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.934810e-01 | 0.307 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.934810e-01 | 0.307 |
| R-HSA-983712 | Ion channel transport | 4.945866e-01 | 0.306 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.977236e-01 | 0.303 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.977236e-01 | 0.303 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.977236e-01 | 0.303 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.977236e-01 | 0.303 |
| R-HSA-9675135 | Diseases of DNA repair | 4.977236e-01 | 0.303 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.009310e-01 | 0.300 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.040988e-01 | 0.297 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 5.040988e-01 | 0.297 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.055233e-01 | 0.296 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.055233e-01 | 0.296 |
| R-HSA-5620924 | Intraflagellar transport | 5.103934e-01 | 0.292 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.166086e-01 | 0.287 |
| R-HSA-73893 | DNA Damage Bypass | 5.166086e-01 | 0.287 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.166135e-01 | 0.287 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.173796e-01 | 0.286 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.173796e-01 | 0.286 |
| R-HSA-446728 | Cell junction organization | 5.267453e-01 | 0.278 |
| R-HSA-912446 | Meiotic recombination | 5.288042e-01 | 0.277 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.328933e-01 | 0.273 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.328933e-01 | 0.273 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.328933e-01 | 0.273 |
| R-HSA-69206 | G1/S Transition | 5.328933e-01 | 0.273 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.346141e-01 | 0.272 |
| R-HSA-9658195 | Leishmania infection | 5.346141e-01 | 0.272 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.347868e-01 | 0.272 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.347868e-01 | 0.272 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.347868e-01 | 0.272 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.347868e-01 | 0.272 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.406937e-01 | 0.267 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.406937e-01 | 0.267 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.406937e-01 | 0.267 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.406937e-01 | 0.267 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.465260e-01 | 0.262 |
| R-HSA-5357801 | Programmed Cell Death | 5.471714e-01 | 0.262 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.522846e-01 | 0.258 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.579704e-01 | 0.253 |
| R-HSA-177929 | Signaling by EGFR | 5.579704e-01 | 0.253 |
| R-HSA-75893 | TNF signaling | 5.579704e-01 | 0.253 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.579704e-01 | 0.253 |
| R-HSA-5578775 | Ion homeostasis | 5.579704e-01 | 0.253 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.678832e-01 | 0.246 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.691273e-01 | 0.245 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.691273e-01 | 0.245 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.691273e-01 | 0.245 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.691273e-01 | 0.245 |
| R-HSA-186712 | Regulation of beta-cell development | 5.746003e-01 | 0.241 |
| R-HSA-195721 | Signaling by WNT | 5.779306e-01 | 0.238 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.800040e-01 | 0.237 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.800040e-01 | 0.237 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.800040e-01 | 0.237 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.800040e-01 | 0.237 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.800040e-01 | 0.237 |
| R-HSA-8873719 | RAB geranylgeranylation | 5.800040e-01 | 0.237 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.800040e-01 | 0.237 |
| R-HSA-379724 | tRNA Aminoacylation | 5.800040e-01 | 0.237 |
| R-HSA-449147 | Signaling by Interleukins | 5.812388e-01 | 0.236 |
| R-HSA-418990 | Adherens junctions interactions | 5.851700e-01 | 0.233 |
| R-HSA-450294 | MAP kinase activation | 5.853395e-01 | 0.233 |
| R-HSA-211976 | Endogenous sterols | 5.853395e-01 | 0.233 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.853395e-01 | 0.233 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.853395e-01 | 0.233 |
| R-HSA-913531 | Interferon Signaling | 5.867298e-01 | 0.232 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.879921e-01 | 0.231 |
| R-HSA-1268020 | Mitochondrial protein import | 5.906075e-01 | 0.229 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.906075e-01 | 0.229 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.906075e-01 | 0.229 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.906075e-01 | 0.229 |
| R-HSA-9707616 | Heme signaling | 5.906075e-01 | 0.229 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.906075e-01 | 0.229 |
| R-HSA-112316 | Neuronal System | 5.927060e-01 | 0.227 |
| R-HSA-373755 | Semaphorin interactions | 5.958088e-01 | 0.225 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.958088e-01 | 0.225 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.009445e-01 | 0.221 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.052618e-01 | 0.218 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.075281e-01 | 0.216 |
| R-HSA-162906 | HIV Infection | 6.102664e-01 | 0.214 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.110217e-01 | 0.214 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.110217e-01 | 0.214 |
| R-HSA-196807 | Nicotinate metabolism | 6.159649e-01 | 0.210 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.159649e-01 | 0.210 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.159649e-01 | 0.210 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.186810e-01 | 0.209 |
| R-HSA-5218859 | Regulated Necrosis | 6.208457e-01 | 0.207 |
| R-HSA-167172 | Transcription of the HIV genome | 6.208457e-01 | 0.207 |
| R-HSA-72312 | rRNA processing | 6.237667e-01 | 0.205 |
| R-HSA-1643685 | Disease | 6.245622e-01 | 0.204 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.304227e-01 | 0.200 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.304227e-01 | 0.200 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.304227e-01 | 0.200 |
| R-HSA-448424 | Interleukin-17 signaling | 6.304227e-01 | 0.200 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.351206e-01 | 0.197 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.351206e-01 | 0.197 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.351206e-01 | 0.197 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.351206e-01 | 0.197 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.351206e-01 | 0.197 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.381511e-01 | 0.195 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.381511e-01 | 0.195 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.397590e-01 | 0.194 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.397590e-01 | 0.194 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.397590e-01 | 0.194 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.397590e-01 | 0.194 |
| R-HSA-9609507 | Protein localization | 6.413196e-01 | 0.193 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.443387e-01 | 0.191 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.443387e-01 | 0.191 |
| R-HSA-4086398 | Ca2+ pathway | 6.443387e-01 | 0.191 |
| R-HSA-73887 | Death Receptor Signaling | 6.444663e-01 | 0.191 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.475913e-01 | 0.189 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.488605e-01 | 0.188 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.488605e-01 | 0.188 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.533251e-01 | 0.185 |
| R-HSA-8852135 | Protein ubiquitination | 6.533251e-01 | 0.185 |
| R-HSA-162587 | HIV Life Cycle | 6.537763e-01 | 0.185 |
| R-HSA-9711097 | Cellular response to starvation | 6.568364e-01 | 0.183 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.577332e-01 | 0.182 |
| R-HSA-5689603 | UCH proteinases | 6.577332e-01 | 0.182 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.620856e-01 | 0.179 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.620856e-01 | 0.179 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.628920e-01 | 0.179 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.663828e-01 | 0.176 |
| R-HSA-5619084 | ABC transporter disorders | 6.663828e-01 | 0.176 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.706256e-01 | 0.174 |
| R-HSA-421270 | Cell-cell junction organization | 6.721261e-01 | 0.173 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.747465e-01 | 0.171 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.748148e-01 | 0.171 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.748148e-01 | 0.171 |
| R-HSA-9833482 | PKR-mediated signaling | 6.748148e-01 | 0.171 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.789509e-01 | 0.168 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.830347e-01 | 0.166 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.870668e-01 | 0.163 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.870668e-01 | 0.163 |
| R-HSA-1500620 | Meiosis | 6.949785e-01 | 0.158 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.949785e-01 | 0.158 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.949785e-01 | 0.158 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.001860e-01 | 0.155 |
| R-HSA-9663891 | Selective autophagy | 7.102096e-01 | 0.149 |
| R-HSA-202424 | Downstream TCR signaling | 7.175389e-01 | 0.144 |
| R-HSA-168255 | Influenza Infection | 7.188184e-01 | 0.143 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.281883e-01 | 0.138 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.350650e-01 | 0.134 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.437255e-01 | 0.129 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.450567e-01 | 0.128 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.450567e-01 | 0.128 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.450567e-01 | 0.128 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.450567e-01 | 0.128 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.483033e-01 | 0.126 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.508473e-01 | 0.124 |
| R-HSA-5368286 | Mitochondrial translation initiation | 7.515087e-01 | 0.124 |
| R-HSA-422356 | Regulation of insulin secretion | 7.515087e-01 | 0.124 |
| R-HSA-190236 | Signaling by FGFR | 7.515087e-01 | 0.124 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.546734e-01 | 0.122 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.546734e-01 | 0.122 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.577981e-01 | 0.120 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.577981e-01 | 0.120 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.608831e-01 | 0.119 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.669364e-01 | 0.115 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.689658e-01 | 0.114 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.699056e-01 | 0.114 |
| R-HSA-428157 | Sphingolipid metabolism | 7.711486e-01 | 0.113 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.754605e-01 | 0.110 |
| R-HSA-418346 | Platelet homeostasis | 7.785892e-01 | 0.109 |
| R-HSA-211000 | Gene Silencing by RNA | 7.814107e-01 | 0.107 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.841963e-01 | 0.106 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.869467e-01 | 0.104 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.896621e-01 | 0.103 |
| R-HSA-202403 | TCR signaling | 7.896621e-01 | 0.103 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.949901e-01 | 0.100 |
| R-HSA-9824446 | Viral Infection Pathways | 7.981405e-01 | 0.098 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.126023e-01 | 0.090 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.126023e-01 | 0.090 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.126023e-01 | 0.090 |
| R-HSA-382551 | Transport of small molecules | 8.259896e-01 | 0.083 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.264946e-01 | 0.083 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.264946e-01 | 0.083 |
| R-HSA-72766 | Translation | 8.268235e-01 | 0.083 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.287082e-01 | 0.082 |
| R-HSA-1266738 | Developmental Biology | 8.340732e-01 | 0.079 |
| R-HSA-15869 | Metabolism of nucleotides | 8.386015e-01 | 0.076 |
| R-HSA-1474165 | Reproduction | 8.454345e-01 | 0.073 |
| R-HSA-9843745 | Adipogenesis | 8.474075e-01 | 0.072 |
| R-HSA-5576891 | Cardiac conduction | 8.474075e-01 | 0.072 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.493555e-01 | 0.071 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.553181e-01 | 0.068 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.587305e-01 | 0.066 |
| R-HSA-163685 | Integration of energy metabolism | 8.587305e-01 | 0.066 |
| R-HSA-5368287 | Mitochondrial translation | 8.623158e-01 | 0.064 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.623158e-01 | 0.064 |
| R-HSA-1632852 | Macroautophagy | 8.675247e-01 | 0.062 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.678087e-01 | 0.062 |
| R-HSA-416476 | G alpha (q) signalling events | 8.780760e-01 | 0.056 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.789287e-01 | 0.056 |
| R-HSA-9758941 | Gastrulation | 8.820037e-01 | 0.055 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.829304e-01 | 0.054 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.835120e-01 | 0.054 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.835120e-01 | 0.054 |
| R-HSA-5663205 | Infectious disease | 8.880116e-01 | 0.052 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.893554e-01 | 0.051 |
| R-HSA-9612973 | Autophagy | 8.921668e-01 | 0.050 |
| R-HSA-392499 | Metabolism of proteins | 8.981553e-01 | 0.047 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.985521e-01 | 0.046 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.064056e-01 | 0.043 |
| R-HSA-5619102 | SLC transporter disorders | 9.064056e-01 | 0.043 |
| R-HSA-72306 | tRNA processing | 9.111055e-01 | 0.040 |
| R-HSA-1483257 | Phospholipid metabolism | 9.113057e-01 | 0.040 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.122433e-01 | 0.040 |
| R-HSA-597592 | Post-translational protein modification | 9.154283e-01 | 0.038 |
| R-HSA-611105 | Respiratory electron transport | 9.198123e-01 | 0.036 |
| R-HSA-9609690 | HCMV Early Events | 9.364230e-01 | 0.029 |
| R-HSA-9679506 | SARS-CoV Infections | 9.373504e-01 | 0.028 |
| R-HSA-1474244 | Extracellular matrix organization | 9.392390e-01 | 0.027 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.396215e-01 | 0.027 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.411601e-01 | 0.026 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.498652e-01 | 0.022 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.595464e-01 | 0.018 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.656827e-01 | 0.015 |
| R-HSA-9609646 | HCMV Infection | 9.687704e-01 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.705638e-01 | 0.013 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.771172e-01 | 0.010 |
| R-HSA-109582 | Hemostasis | 9.776136e-01 | 0.010 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.782740e-01 | 0.010 |
| R-HSA-6798695 | Neutrophil degranulation | 9.849052e-01 | 0.007 |
| R-HSA-8957322 | Metabolism of steroids | 9.880469e-01 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.904195e-01 | 0.004 |
| R-HSA-168249 | Innate Immune System | 9.910568e-01 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.929007e-01 | 0.003 |
| R-HSA-1280218 | Adaptive Immune System | 9.940094e-01 | 0.003 |
| R-HSA-168256 | Immune System | 9.942533e-01 | 0.003 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.950093e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.960037e-01 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.967159e-01 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 9.969240e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.976478e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.991283e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.996381e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.997204e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998693e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999410e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.879 | 0.547 | 1 | 0.927 |
NLK |
0.877 | 0.585 | 1 | 0.890 |
CLK3 |
0.871 | 0.409 | 1 | 0.888 |
ERK5 |
0.870 | 0.366 | 1 | 0.873 |
CDK18 |
0.869 | 0.612 | 1 | 0.897 |
CDK8 |
0.868 | 0.554 | 1 | 0.897 |
CDK5 |
0.868 | 0.602 | 1 | 0.921 |
CDK19 |
0.867 | 0.554 | 1 | 0.889 |
CDK7 |
0.865 | 0.555 | 1 | 0.920 |
COT |
0.865 | 0.014 | 2 | 0.858 |
CDK17 |
0.865 | 0.614 | 1 | 0.863 |
CDK1 |
0.864 | 0.595 | 1 | 0.890 |
ERK1 |
0.863 | 0.588 | 1 | 0.914 |
JNK2 |
0.863 | 0.625 | 1 | 0.897 |
P38G |
0.863 | 0.619 | 1 | 0.860 |
CDK13 |
0.862 | 0.563 | 1 | 0.916 |
CDK16 |
0.862 | 0.631 | 1 | 0.877 |
P38A |
0.861 | 0.583 | 1 | 0.933 |
CDK14 |
0.861 | 0.616 | 1 | 0.907 |
SRPK1 |
0.861 | 0.271 | -3 | 0.740 |
CDK3 |
0.860 | 0.583 | 1 | 0.876 |
CDKL5 |
0.860 | 0.183 | -3 | 0.786 |
P38B |
0.860 | 0.592 | 1 | 0.914 |
JNK3 |
0.860 | 0.603 | 1 | 0.913 |
DYRK2 |
0.859 | 0.519 | 1 | 0.894 |
ERK2 |
0.859 | 0.586 | 1 | 0.924 |
CDKL1 |
0.858 | 0.146 | -3 | 0.799 |
MTOR |
0.858 | 0.103 | 1 | 0.761 |
HIPK4 |
0.858 | 0.305 | 1 | 0.856 |
CDK12 |
0.857 | 0.566 | 1 | 0.903 |
CDK2 |
0.857 | 0.500 | 1 | 0.881 |
NUAK2 |
0.857 | 0.115 | -3 | 0.829 |
CDK10 |
0.856 | 0.590 | 1 | 0.903 |
P38D |
0.856 | 0.609 | 1 | 0.884 |
HIPK2 |
0.855 | 0.537 | 1 | 0.878 |
SRPK2 |
0.854 | 0.236 | -3 | 0.669 |
CDK9 |
0.854 | 0.547 | 1 | 0.919 |
MOS |
0.854 | 0.007 | 1 | 0.726 |
PRPK |
0.854 | -0.129 | -1 | 0.866 |
HIPK1 |
0.854 | 0.505 | 1 | 0.904 |
GCN2 |
0.853 | -0.149 | 2 | 0.795 |
DSTYK |
0.853 | -0.039 | 2 | 0.853 |
CDC7 |
0.853 | -0.088 | 1 | 0.660 |
MST4 |
0.853 | 0.092 | 2 | 0.856 |
CAMK1B |
0.853 | 0.035 | -3 | 0.861 |
ICK |
0.853 | 0.259 | -3 | 0.820 |
CLK1 |
0.852 | 0.355 | -3 | 0.742 |
NEK6 |
0.852 | 0.015 | -2 | 0.894 |
ULK2 |
0.851 | -0.112 | 2 | 0.795 |
PRKD2 |
0.851 | 0.102 | -3 | 0.744 |
RAF1 |
0.850 | -0.133 | 1 | 0.676 |
PRKD1 |
0.849 | 0.062 | -3 | 0.783 |
CLK4 |
0.849 | 0.316 | -3 | 0.763 |
PKN3 |
0.849 | 0.027 | -3 | 0.824 |
HIPK3 |
0.849 | 0.483 | 1 | 0.897 |
BMPR2 |
0.849 | -0.114 | -2 | 0.914 |
PIM3 |
0.849 | -0.001 | -3 | 0.809 |
WNK1 |
0.848 | 0.022 | -2 | 0.868 |
PKN2 |
0.848 | 0.060 | -3 | 0.830 |
NIK |
0.848 | 0.041 | -3 | 0.877 |
NEK7 |
0.847 | -0.084 | -3 | 0.850 |
PDHK4 |
0.847 | -0.243 | 1 | 0.725 |
SRPK3 |
0.847 | 0.190 | -3 | 0.726 |
CDK6 |
0.847 | 0.582 | 1 | 0.906 |
TBK1 |
0.846 | -0.144 | 1 | 0.602 |
PKCD |
0.846 | 0.088 | 2 | 0.820 |
DYRK1A |
0.846 | 0.423 | 1 | 0.918 |
AMPKA1 |
0.845 | 0.043 | -3 | 0.835 |
ATR |
0.845 | -0.079 | 1 | 0.683 |
MLK1 |
0.845 | -0.059 | 2 | 0.827 |
IKKB |
0.845 | -0.185 | -2 | 0.779 |
TGFBR2 |
0.844 | -0.033 | -2 | 0.844 |
CHAK2 |
0.844 | -0.014 | -1 | 0.860 |
PIM1 |
0.844 | 0.083 | -3 | 0.765 |
RIPK3 |
0.844 | -0.071 | 3 | 0.800 |
CAMLCK |
0.843 | 0.022 | -2 | 0.882 |
PDHK1 |
0.843 | -0.199 | 1 | 0.706 |
IRE1 |
0.843 | 0.001 | 1 | 0.660 |
IKKE |
0.843 | -0.156 | 1 | 0.594 |
CDK4 |
0.843 | 0.578 | 1 | 0.898 |
DYRK1B |
0.842 | 0.499 | 1 | 0.894 |
NUAK1 |
0.842 | 0.053 | -3 | 0.782 |
TSSK2 |
0.842 | 0.055 | -5 | 0.888 |
TSSK1 |
0.842 | 0.076 | -3 | 0.848 |
NEK9 |
0.842 | -0.071 | 2 | 0.850 |
PRKD3 |
0.841 | 0.083 | -3 | 0.732 |
PRP4 |
0.841 | 0.398 | -3 | 0.819 |
RSK2 |
0.841 | 0.030 | -3 | 0.756 |
NDR2 |
0.841 | -0.063 | -3 | 0.807 |
NDR1 |
0.841 | -0.027 | -3 | 0.811 |
AMPKA2 |
0.841 | 0.048 | -3 | 0.801 |
DYRK4 |
0.840 | 0.506 | 1 | 0.890 |
DYRK3 |
0.839 | 0.404 | 1 | 0.879 |
CAMK2G |
0.839 | -0.159 | 2 | 0.755 |
HUNK |
0.839 | -0.137 | 2 | 0.791 |
IRE2 |
0.839 | 0.020 | 2 | 0.802 |
ULK1 |
0.838 | -0.165 | -3 | 0.832 |
AURC |
0.838 | 0.082 | -2 | 0.698 |
WNK3 |
0.838 | -0.170 | 1 | 0.668 |
MARK4 |
0.838 | -0.050 | 4 | 0.845 |
RSK3 |
0.838 | 0.005 | -3 | 0.755 |
MAPKAPK3 |
0.838 | -0.006 | -3 | 0.745 |
DAPK2 |
0.838 | -0.029 | -3 | 0.863 |
P90RSK |
0.837 | 0.003 | -3 | 0.761 |
CLK2 |
0.837 | 0.317 | -3 | 0.737 |
P70S6KB |
0.837 | 0.016 | -3 | 0.791 |
NIM1 |
0.837 | -0.043 | 3 | 0.822 |
MLK3 |
0.837 | 0.016 | 2 | 0.779 |
PKCA |
0.836 | 0.073 | 2 | 0.775 |
PKR |
0.836 | 0.032 | 1 | 0.696 |
MELK |
0.836 | 0.016 | -3 | 0.789 |
SKMLCK |
0.835 | -0.051 | -2 | 0.867 |
MNK2 |
0.835 | 0.049 | -2 | 0.823 |
PKCB |
0.834 | 0.062 | 2 | 0.782 |
MLK2 |
0.834 | -0.105 | 2 | 0.828 |
JNK1 |
0.834 | 0.517 | 1 | 0.886 |
PINK1 |
0.833 | 0.126 | 1 | 0.803 |
PKCG |
0.833 | 0.047 | 2 | 0.778 |
PAK6 |
0.833 | 0.073 | -2 | 0.744 |
ANKRD3 |
0.833 | -0.123 | 1 | 0.682 |
GRK5 |
0.833 | -0.227 | -3 | 0.855 |
PHKG1 |
0.833 | -0.008 | -3 | 0.804 |
PKACG |
0.833 | -0.001 | -2 | 0.774 |
ERK7 |
0.832 | 0.224 | 2 | 0.570 |
BCKDK |
0.831 | -0.198 | -1 | 0.794 |
QIK |
0.831 | -0.050 | -3 | 0.832 |
NEK2 |
0.831 | -0.044 | 2 | 0.829 |
CAMK4 |
0.831 | -0.067 | -3 | 0.810 |
RIPK1 |
0.830 | -0.195 | 1 | 0.647 |
PKCH |
0.830 | 0.033 | 2 | 0.767 |
LATS2 |
0.830 | -0.073 | -5 | 0.734 |
AURB |
0.829 | 0.049 | -2 | 0.697 |
PKCZ |
0.829 | 0.011 | 2 | 0.807 |
PAK3 |
0.829 | -0.046 | -2 | 0.807 |
IKKA |
0.829 | -0.148 | -2 | 0.762 |
MASTL |
0.829 | -0.283 | -2 | 0.836 |
MAPKAPK2 |
0.829 | -0.005 | -3 | 0.694 |
CHAK1 |
0.828 | -0.082 | 2 | 0.788 |
MNK1 |
0.828 | 0.044 | -2 | 0.834 |
AKT2 |
0.828 | 0.074 | -3 | 0.686 |
ALK4 |
0.828 | -0.057 | -2 | 0.853 |
PAK1 |
0.828 | -0.021 | -2 | 0.801 |
PLK1 |
0.828 | -0.068 | -2 | 0.879 |
TTBK2 |
0.828 | -0.207 | 2 | 0.714 |
ATM |
0.827 | -0.096 | 1 | 0.610 |
CAMK2D |
0.827 | -0.136 | -3 | 0.829 |
GRK6 |
0.827 | -0.171 | 1 | 0.642 |
PIM2 |
0.827 | 0.063 | -3 | 0.741 |
BMPR1B |
0.827 | -0.012 | 1 | 0.596 |
VRK2 |
0.826 | -0.075 | 1 | 0.751 |
SIK |
0.826 | -0.019 | -3 | 0.751 |
DLK |
0.826 | -0.271 | 1 | 0.650 |
MAK |
0.825 | 0.363 | -2 | 0.723 |
HRI |
0.825 | -0.068 | -2 | 0.883 |
QSK |
0.825 | -0.030 | 4 | 0.834 |
YSK4 |
0.825 | -0.121 | 1 | 0.622 |
PKG2 |
0.825 | 0.038 | -2 | 0.713 |
GRK1 |
0.825 | -0.100 | -2 | 0.795 |
LATS1 |
0.824 | -0.011 | -3 | 0.808 |
CAMK1G |
0.824 | 0.004 | -3 | 0.765 |
IRAK4 |
0.824 | -0.015 | 1 | 0.656 |
MYLK4 |
0.824 | 0.001 | -2 | 0.804 |
CHK1 |
0.824 | -0.005 | -3 | 0.790 |
MLK4 |
0.823 | -0.080 | 2 | 0.745 |
SGK3 |
0.823 | 0.031 | -3 | 0.747 |
PHKG2 |
0.823 | 0.016 | -3 | 0.797 |
MOK |
0.823 | 0.345 | 1 | 0.876 |
TGFBR1 |
0.822 | -0.062 | -2 | 0.829 |
PERK |
0.822 | -0.100 | -2 | 0.878 |
MSK2 |
0.822 | -0.049 | -3 | 0.723 |
MEK1 |
0.821 | -0.217 | 2 | 0.804 |
FAM20C |
0.821 | -0.063 | 2 | 0.492 |
PKACB |
0.821 | 0.046 | -2 | 0.715 |
MST3 |
0.821 | 0.052 | 2 | 0.850 |
PAK2 |
0.821 | -0.058 | -2 | 0.790 |
PKCT |
0.820 | 0.027 | 2 | 0.775 |
SMG1 |
0.820 | -0.113 | 1 | 0.646 |
NEK5 |
0.820 | -0.046 | 1 | 0.680 |
ACVR2A |
0.820 | -0.070 | -2 | 0.834 |
PKCI |
0.820 | 0.055 | 2 | 0.778 |
WNK4 |
0.819 | -0.076 | -2 | 0.855 |
MEKK2 |
0.819 | -0.059 | 2 | 0.813 |
SNRK |
0.819 | -0.159 | 2 | 0.677 |
BRSK1 |
0.819 | -0.064 | -3 | 0.778 |
DCAMKL1 |
0.819 | -0.007 | -3 | 0.761 |
GRK4 |
0.818 | -0.247 | -2 | 0.840 |
AKT1 |
0.818 | 0.064 | -3 | 0.695 |
RSK4 |
0.818 | -0.000 | -3 | 0.722 |
MEKK1 |
0.818 | -0.126 | 1 | 0.650 |
SSTK |
0.818 | 0.020 | 4 | 0.827 |
ACVR2B |
0.818 | -0.081 | -2 | 0.843 |
GRK7 |
0.817 | -0.048 | 1 | 0.631 |
PRKX |
0.817 | 0.073 | -3 | 0.660 |
MPSK1 |
0.817 | 0.045 | 1 | 0.714 |
BRSK2 |
0.817 | -0.096 | -3 | 0.805 |
MARK3 |
0.817 | -0.041 | 4 | 0.795 |
MARK2 |
0.817 | -0.056 | 4 | 0.755 |
DNAPK |
0.817 | -0.072 | 1 | 0.596 |
CAMK2B |
0.817 | -0.089 | 2 | 0.698 |
ALK2 |
0.817 | -0.077 | -2 | 0.845 |
PKCE |
0.817 | 0.099 | 2 | 0.772 |
AURA |
0.816 | 0.012 | -2 | 0.672 |
MAPKAPK5 |
0.816 | -0.107 | -3 | 0.712 |
PLK4 |
0.816 | -0.117 | 2 | 0.622 |
CAMK2A |
0.816 | -0.066 | 2 | 0.727 |
MEKK3 |
0.815 | -0.156 | 1 | 0.639 |
MEK5 |
0.815 | -0.194 | 2 | 0.814 |
SMMLCK |
0.815 | -0.002 | -3 | 0.820 |
ZAK |
0.814 | -0.141 | 1 | 0.606 |
MSK1 |
0.814 | -0.027 | -3 | 0.729 |
GAK |
0.814 | 0.059 | 1 | 0.742 |
PKN1 |
0.813 | 0.037 | -3 | 0.721 |
TAO3 |
0.813 | -0.019 | 1 | 0.660 |
DCAMKL2 |
0.813 | -0.030 | -3 | 0.792 |
BRAF |
0.813 | -0.149 | -4 | 0.778 |
PLK3 |
0.813 | -0.138 | 2 | 0.713 |
TAO2 |
0.813 | 0.011 | 2 | 0.862 |
NEK8 |
0.812 | -0.084 | 2 | 0.836 |
P70S6K |
0.812 | -0.019 | -3 | 0.707 |
MARK1 |
0.811 | -0.084 | 4 | 0.817 |
NEK4 |
0.811 | -0.032 | 1 | 0.651 |
GSK3A |
0.810 | 0.099 | 4 | 0.421 |
CAMK1D |
0.809 | 0.013 | -3 | 0.680 |
TLK2 |
0.809 | -0.198 | 1 | 0.619 |
TLK1 |
0.809 | -0.148 | -2 | 0.856 |
BMPR1A |
0.809 | -0.039 | 1 | 0.568 |
TNIK |
0.809 | 0.067 | 3 | 0.887 |
DRAK1 |
0.808 | -0.178 | 1 | 0.554 |
CK1E |
0.808 | -0.061 | -3 | 0.540 |
NEK11 |
0.808 | -0.128 | 1 | 0.644 |
HGK |
0.807 | 0.013 | 3 | 0.888 |
PKACA |
0.807 | 0.032 | -2 | 0.665 |
PAK5 |
0.807 | -0.001 | -2 | 0.674 |
CAMKK1 |
0.807 | -0.147 | -2 | 0.823 |
GRK2 |
0.807 | -0.149 | -2 | 0.721 |
LKB1 |
0.807 | -0.048 | -3 | 0.851 |
BUB1 |
0.807 | 0.113 | -5 | 0.819 |
CHK2 |
0.806 | 0.030 | -3 | 0.629 |
IRAK1 |
0.806 | -0.207 | -1 | 0.761 |
MEKK6 |
0.806 | -0.038 | 1 | 0.659 |
EEF2K |
0.806 | -0.001 | 3 | 0.856 |
MINK |
0.805 | -0.012 | 1 | 0.645 |
NEK1 |
0.805 | -0.018 | 1 | 0.657 |
MRCKB |
0.805 | 0.063 | -3 | 0.738 |
LOK |
0.805 | 0.001 | -2 | 0.810 |
PDK1 |
0.804 | -0.092 | 1 | 0.667 |
TTBK1 |
0.804 | -0.191 | 2 | 0.636 |
CAMK1A |
0.804 | 0.043 | -3 | 0.644 |
GSK3B |
0.803 | -0.021 | 4 | 0.412 |
PAK4 |
0.803 | 0.004 | -2 | 0.685 |
MST2 |
0.803 | -0.060 | 1 | 0.647 |
AKT3 |
0.803 | 0.056 | -3 | 0.610 |
CK1D |
0.803 | -0.040 | -3 | 0.489 |
LRRK2 |
0.802 | -0.042 | 2 | 0.843 |
CAMKK2 |
0.802 | -0.135 | -2 | 0.816 |
SBK |
0.802 | 0.099 | -3 | 0.563 |
DAPK3 |
0.801 | -0.004 | -3 | 0.786 |
GCK |
0.801 | -0.044 | 1 | 0.651 |
PBK |
0.800 | 0.043 | 1 | 0.704 |
MRCKA |
0.799 | 0.038 | -3 | 0.746 |
SGK1 |
0.799 | 0.046 | -3 | 0.599 |
CK1G1 |
0.799 | -0.104 | -3 | 0.536 |
PASK |
0.798 | -0.124 | -3 | 0.826 |
MAP3K15 |
0.798 | -0.114 | 1 | 0.616 |
HPK1 |
0.798 | -0.030 | 1 | 0.643 |
MST1 |
0.798 | -0.046 | 1 | 0.636 |
ROCK2 |
0.798 | 0.051 | -3 | 0.769 |
CK1A2 |
0.798 | -0.061 | -3 | 0.492 |
KHS1 |
0.797 | 0.017 | 1 | 0.649 |
KHS2 |
0.797 | 0.050 | 1 | 0.658 |
YSK1 |
0.797 | -0.034 | 2 | 0.832 |
NEK3 |
0.797 | -0.053 | 1 | 0.633 |
TAK1 |
0.797 | -0.142 | 1 | 0.651 |
DMPK1 |
0.796 | 0.094 | -3 | 0.753 |
HASPIN |
0.795 | 0.052 | -1 | 0.713 |
BIKE |
0.794 | 0.087 | 1 | 0.676 |
VRK1 |
0.794 | -0.165 | 2 | 0.845 |
TTK |
0.792 | 0.033 | -2 | 0.872 |
DAPK1 |
0.792 | -0.027 | -3 | 0.778 |
RIPK2 |
0.791 | -0.223 | 1 | 0.572 |
SLK |
0.791 | -0.079 | -2 | 0.739 |
MYO3B |
0.789 | 0.035 | 2 | 0.848 |
GRK3 |
0.789 | -0.153 | -2 | 0.670 |
ROCK1 |
0.789 | 0.047 | -3 | 0.746 |
MEK2 |
0.788 | -0.242 | 2 | 0.793 |
CK2A2 |
0.788 | -0.080 | 1 | 0.532 |
STK33 |
0.788 | -0.167 | 2 | 0.610 |
PKG1 |
0.788 | -0.005 | -2 | 0.638 |
PDHK3_TYR |
0.787 | 0.037 | 4 | 0.877 |
CRIK |
0.786 | 0.043 | -3 | 0.684 |
MYO3A |
0.784 | 0.009 | 1 | 0.645 |
PLK2 |
0.784 | -0.098 | -3 | 0.801 |
PKMYT1_TYR |
0.784 | 0.059 | 3 | 0.890 |
TESK1_TYR |
0.784 | 0.005 | 3 | 0.903 |
LIMK2_TYR |
0.784 | 0.123 | -3 | 0.877 |
AAK1 |
0.783 | 0.123 | 1 | 0.623 |
OSR1 |
0.782 | -0.076 | 2 | 0.795 |
TAO1 |
0.782 | -0.040 | 1 | 0.598 |
MAP2K4_TYR |
0.780 | -0.090 | -1 | 0.890 |
PINK1_TYR |
0.779 | -0.110 | 1 | 0.711 |
MAP2K7_TYR |
0.778 | -0.175 | 2 | 0.829 |
BMPR2_TYR |
0.778 | -0.020 | -1 | 0.895 |
MAP2K6_TYR |
0.777 | -0.077 | -1 | 0.896 |
LIMK1_TYR |
0.777 | -0.010 | 2 | 0.847 |
PDHK4_TYR |
0.776 | -0.067 | 2 | 0.832 |
CK2A1 |
0.775 | -0.107 | 1 | 0.507 |
ASK1 |
0.775 | -0.163 | 1 | 0.607 |
ROS1 |
0.775 | -0.049 | 3 | 0.840 |
TYK2 |
0.774 | -0.121 | 1 | 0.664 |
RET |
0.774 | -0.097 | 1 | 0.666 |
MST1R |
0.774 | -0.072 | 3 | 0.865 |
EPHA6 |
0.773 | -0.030 | -1 | 0.878 |
JAK2 |
0.773 | -0.090 | 1 | 0.671 |
PDHK1_TYR |
0.772 | -0.151 | -1 | 0.904 |
TYRO3 |
0.771 | -0.115 | 3 | 0.861 |
ABL2 |
0.770 | -0.046 | -1 | 0.827 |
CSF1R |
0.769 | -0.091 | 3 | 0.855 |
ALPHAK3 |
0.768 | -0.126 | -1 | 0.806 |
EPHB4 |
0.767 | -0.099 | -1 | 0.850 |
ABL1 |
0.767 | -0.055 | -1 | 0.819 |
TNNI3K_TYR |
0.767 | 0.013 | 1 | 0.682 |
YES1 |
0.767 | -0.061 | -1 | 0.841 |
HCK |
0.766 | -0.069 | -1 | 0.831 |
LCK |
0.766 | -0.009 | -1 | 0.832 |
JAK1 |
0.765 | -0.039 | 1 | 0.611 |
FGR |
0.765 | -0.112 | 1 | 0.696 |
BLK |
0.765 | 0.010 | -1 | 0.839 |
KDR |
0.764 | -0.042 | 3 | 0.814 |
JAK3 |
0.764 | -0.104 | 1 | 0.638 |
TNK1 |
0.764 | -0.038 | 3 | 0.841 |
TNK2 |
0.764 | -0.071 | 3 | 0.806 |
FLT3 |
0.763 | -0.116 | 3 | 0.854 |
DDR1 |
0.762 | -0.174 | 4 | 0.795 |
NEK10_TYR |
0.762 | -0.095 | 1 | 0.588 |
INSRR |
0.761 | -0.119 | 3 | 0.805 |
YANK3 |
0.761 | -0.116 | 2 | 0.390 |
TXK |
0.761 | -0.065 | 1 | 0.632 |
TEK |
0.761 | -0.060 | 3 | 0.801 |
FER |
0.760 | -0.189 | 1 | 0.690 |
PDGFRB |
0.760 | -0.173 | 3 | 0.863 |
FGFR1 |
0.759 | -0.087 | 3 | 0.821 |
FGFR2 |
0.758 | -0.112 | 3 | 0.829 |
STLK3 |
0.758 | -0.247 | 1 | 0.580 |
WEE1_TYR |
0.758 | -0.065 | -1 | 0.753 |
ITK |
0.757 | -0.125 | -1 | 0.809 |
KIT |
0.757 | -0.149 | 3 | 0.854 |
PDGFRA |
0.756 | -0.182 | 3 | 0.862 |
CK1A |
0.756 | -0.109 | -3 | 0.401 |
EPHB1 |
0.755 | -0.164 | 1 | 0.641 |
EPHB3 |
0.754 | -0.155 | -1 | 0.830 |
EPHB2 |
0.754 | -0.134 | -1 | 0.833 |
EPHA4 |
0.753 | -0.136 | 2 | 0.708 |
TEC |
0.753 | -0.117 | -1 | 0.743 |
BTK |
0.753 | -0.195 | -1 | 0.770 |
SRMS |
0.753 | -0.207 | 1 | 0.648 |
ALK |
0.753 | -0.144 | 3 | 0.790 |
LTK |
0.752 | -0.138 | 3 | 0.810 |
AXL |
0.752 | -0.190 | 3 | 0.826 |
MET |
0.751 | -0.149 | 3 | 0.835 |
BMX |
0.751 | -0.114 | -1 | 0.738 |
MERTK |
0.751 | -0.170 | 3 | 0.821 |
FYN |
0.750 | -0.053 | -1 | 0.808 |
FLT1 |
0.750 | -0.120 | -1 | 0.866 |
FRK |
0.749 | -0.124 | -1 | 0.845 |
LYN |
0.748 | -0.106 | 3 | 0.786 |
FLT4 |
0.748 | -0.147 | 3 | 0.806 |
ERBB2 |
0.748 | -0.180 | 1 | 0.607 |
FGFR3 |
0.746 | -0.138 | 3 | 0.807 |
INSR |
0.746 | -0.178 | 3 | 0.791 |
EPHA1 |
0.745 | -0.169 | 3 | 0.818 |
NTRK2 |
0.745 | -0.224 | 3 | 0.808 |
NTRK1 |
0.745 | -0.248 | -1 | 0.829 |
EPHA7 |
0.744 | -0.154 | 2 | 0.724 |
PTK6 |
0.744 | -0.254 | -1 | 0.736 |
DDR2 |
0.743 | -0.069 | 3 | 0.789 |
MATK |
0.742 | -0.136 | -1 | 0.765 |
EPHA3 |
0.742 | -0.188 | 2 | 0.693 |
CK1G3 |
0.742 | -0.091 | -3 | 0.358 |
SRC |
0.741 | -0.113 | -1 | 0.804 |
MUSK |
0.739 | -0.128 | 1 | 0.522 |
PTK2B |
0.739 | -0.143 | -1 | 0.772 |
NTRK3 |
0.738 | -0.198 | -1 | 0.779 |
PTK2 |
0.736 | -0.054 | -1 | 0.827 |
EGFR |
0.735 | -0.140 | 1 | 0.523 |
EPHA8 |
0.735 | -0.153 | -1 | 0.817 |
EPHA5 |
0.734 | -0.176 | 2 | 0.688 |
CSK |
0.732 | -0.215 | 2 | 0.733 |
FGFR4 |
0.731 | -0.164 | -1 | 0.796 |
SYK |
0.729 | -0.098 | -1 | 0.806 |
YANK2 |
0.727 | -0.142 | 2 | 0.402 |
IGF1R |
0.727 | -0.181 | 3 | 0.732 |
EPHA2 |
0.724 | -0.164 | -1 | 0.797 |
ERBB4 |
0.722 | -0.130 | 1 | 0.526 |
FES |
0.715 | -0.189 | -1 | 0.714 |
ZAP70 |
0.713 | -0.093 | -1 | 0.729 |
CK1G2 |
0.713 | -0.121 | -3 | 0.455 |