Motif 77 (n=95)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP49 | CCDC187 | S519 | ochoa | Coiled-coil domain-containing protein 187 | None |
| A8MYZ6 | FOXO6 | S214 | ochoa | Forkhead box protein O6 | Transcriptional activator. {ECO:0000250}. |
| H3BRB1 | None | S138 | ochoa | polynucleotide adenylyltransferase (EC 2.7.7.19) | None |
| O00167 | EYA2 | S260 | ochoa | Protein phosphatase EYA2 (EC 3.1.3.48) (Eyes absent homolog 2) | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047, ECO:0000269|PubMed:23435380}. |
| O00213 | APBB1 | S610 | psp | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) | Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347). {ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:36250347}. |
| O00268 | TAF4 | S543 | ochoa | Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}. |
| O14598 | VCY | S27 | ochoa | Testis-specific basic protein Y 1 (Basic charge, Y-linked 1) (Variably charged protein Y) | May mediate a process in spermatogenesis or may play a role in sex ratio distortion. |
| O14715 | RGPD8 | S21 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14917 | PCDH17 | S1080 | ochoa | Protocadherin-17 (Protocadherin-68) | Potential calcium-dependent cell-adhesion protein. |
| O14964 | HGS | Y289 | ochoa | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
| O15061 | SYNM | S1044 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43175 | PHGDH | S326 | ochoa | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O60346 | PHLPP1 | S425 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60941 | DTNB | S394 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75069 | TMCC2 | S470 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75122 | CLASP2 | S25 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O94941 | UBOX5 | S388 | ochoa | RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) | May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. {ECO:0000250|UniProtKB:Q925F4}. |
| O95239 | KIF4A | S1186 | ochoa|psp | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| P14618 | PKM | S97 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P14618 | PKM | S333 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P15822 | HIVEP1 | S2599 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P18206 | VCL | S596 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P23443 | RPS6KB1 | S447 | ochoa|psp | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}. |
| P26232 | CTNNA2 | S321 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P27815 | PDE4A | S157 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P29536 | LMOD1 | S516 | ochoa | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}. |
| P35221 | CTNNA1 | S323 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P38432 | COIL | S218 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P42768 | WAS | S221 | ochoa | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}. |
| P46781 | RPS9 | S163 | ochoa | Small ribosomal subunit protein uS4 (40S ribosomal protein S9) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P49006 | MARCKSL1 | S41 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49790 | NUP153 | S522 | ochoa|psp | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S21 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S960 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P54253 | ATXN1 | S88 | ochoa | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
| Q02641 | CACNB1 | S417 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q02952 | AKAP12 | S20 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q13207 | TBX2 | S657 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q14161 | GIT2 | S668 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q15361 | TTF1 | S65 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15772 | SPEG | S19 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15772 | SPEG | S2500 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q2M2I8 | AAK1 | S327 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q4KMP7 | TBC1D10B | S656 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q5C9Z4 | NOM1 | S139 | ochoa | Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) | Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}. |
| Q5SQ64 | LY6G6F | S270 | ochoa | Lymphocyte antigen 6 complex locus protein G6f | May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. {ECO:0000269|PubMed:12852788}. |
| Q5TGY3 | AHDC1 | S1064 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VT52 | RPRD2 | S1237 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q6EKJ0 | GTF2IRD2B | S516 | ochoa | General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) | None |
| Q6P4I2 | WDR73 | S216 | ochoa | Integrator complex assembly factor WDR73 (WD repeat-containing protein 73) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489). Associates with INTS9 and INTS11 in the cytoplasm, stabilizing the INTS9-INTS11 heterodimer and blocking the active site of INTS11 (PubMed:39032489). BRAT1 then joins the complex and plugs the active site of INTS11, leading to WDR73 release and nuclear import of INTS9 and INTS11 (PubMed:39032489). {ECO:0000269|PubMed:39032489}. |
| Q6ZNB6 | NFXL1 | S331 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q7Z3B3 | KANSL1 | S1082 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z5Q1 | CPEB2 | S164 | ochoa | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) | May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}. |
| Q7Z7B0 | FILIP1 | S1005 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q86V15 | CASZ1 | S57 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q8IY92 | SLX4 | S1631 | psp | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N3J3 | HROB | S208 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8NC74 | RBBP8NL | S145 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8ND30 | PPFIBP2 | S363 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8TAB3 | PCDH19 | S983 | ochoa | Protocadherin-19 | Calcium-dependent cell-adhesion protein. {ECO:0000250|UniProtKB:F8W3X3}. |
| Q8TES7 | FBF1 | S511 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TEX9 | IPO4 | S972 | ochoa | Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148). {ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:12610148, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485}. |
| Q8WUH6 | TMEM263 | S77 | ochoa | Transmembrane protein 263 | May play a role in bone development. {ECO:0000269|PubMed:34238371}. |
| Q8WVS4 | DYNC2I1 | S457 | ochoa | Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:29742051, PubMed:31451806). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Also requires to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:23910462, ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997, ECO:0000269|PubMed:31451806}. |
| Q8WWQ0 | PHIP | S1522 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WX93 | PALLD | S1333 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q99490 | AGAP2 | S615 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99502 | EYA1 | S314 | ochoa | Protein phosphatase EYA1 (EC 3.1.3.16) (EC 3.1.3.48) (Eyes absent homolog 1) | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Also has phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity). {ECO:0000250|UniProtKB:P97767, ECO:0000269|PubMed:19234442}. |
| Q99666 | RGPD5 | S21 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99698 | LYST | S2217 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99814 | EPAS1 | S672 | psp | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}. |
| Q9BUA3 | SPINDOC | S152 | ochoa | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}. |
| Q9BUB5 | MKNK1 | S437 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BW04 | SARG | S580 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9H6E5 | TUT1 | S138 | ochoa | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}. |
| Q9HC77 | CPAP | S731 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NRC1 | ST7 | S386 | ochoa | Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG) | May act as a tumor suppressor. {ECO:0000269|PubMed:16474848}. |
| Q9NTI5 | PDS5B | S1383 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NV92 | NDFIP2 | Y177 | psp | NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413) | Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q91ZP6, ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535, ECO:0000269|PubMed:26363003}. |
| Q9P2K6 | KLHL42 | S171 | ochoa | Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. {ECO:0000269|PubMed:19261606}. |
| Q9UBN7 | HDAC6 | S22 | ochoa|psp | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UID6 | ZNF639 | S88 | ochoa | Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) | Binds DNA and may function as a transcriptional repressor. {ECO:0000269|PubMed:16182284}. |
| Q9ULU4 | ZMYND8 | S756 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULU4 | ZMYND8 | S797 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULV3 | CIZ1 | S838 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMN6 | KMT2B | S861 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UNL4 | ING4 | S124 | ochoa | Inhibitor of growth protein 4 (p29ING4) | Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}. |
| Q9UNZ2 | NSFL1C | S114 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9Y4J8 | DTNA | S366 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y534 | CSDC2 | S47 | ochoa | Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}. |
| Q9Y6M5 | SLC30A1 | S473 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6R9 | CCDC61 | S473 | ochoa | Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}. |
| P52789 | HK2 | S889 | Sugiyama | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| Q6P0Q8 | MAST2 | S996 | Sugiyama | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q9BQI3 | EIF2AK1 | S144 | Sugiyama | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-70171 | Glycolysis | 0.000070 | 4.158 |
| R-HSA-70326 | Glucose metabolism | 0.000170 | 3.769 |
| R-HSA-9830369 | Kidney development | 0.001246 | 2.905 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.036222 | 1.441 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.021007 | 1.678 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.022103 | 1.656 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.022103 | 1.656 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.024364 | 1.613 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.024364 | 1.613 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.025528 | 1.593 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.027924 | 1.554 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.032973 | 1.482 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.034287 | 1.465 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.034287 | 1.465 |
| R-HSA-167161 | HIV Transcription Initiation | 0.036976 | 1.432 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.036976 | 1.432 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.042587 | 1.371 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.039743 | 1.401 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.036976 | 1.432 |
| R-HSA-525793 | Myogenesis | 0.016862 | 1.773 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.030406 | 1.517 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.042587 | 1.371 |
| R-HSA-68877 | Mitotic Prometaphase | 0.042304 | 1.374 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.014014 | 1.853 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.025528 | 1.593 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.022103 | 1.656 |
| R-HSA-9635644 | Inhibition of membrane repair | 0.018276 | 1.738 |
| R-HSA-165159 | MTOR signalling | 0.038350 | 1.416 |
| R-HSA-5617833 | Cilium Assembly | 0.040509 | 1.392 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.026715 | 1.573 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.034287 | 1.465 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.034287 | 1.465 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.035622 | 1.448 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.027924 | 1.554 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.031679 | 1.499 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.044036 | 1.356 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.017408 | 1.759 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.032973 | 1.482 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.042132 | 1.375 |
| R-HSA-8854214 | TBC/RABGAPs | 0.039743 | 1.401 |
| R-HSA-162587 | HIV Life Cycle | 0.023256 | 1.633 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.031679 | 1.499 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.014014 | 1.853 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.012245 | 1.912 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.008395 | 2.076 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.011369 | 1.944 |
| R-HSA-9830364 | Formation of the nephric duct | 0.015888 | 1.799 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.021594 | 1.666 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.037492 | 1.426 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.037492 | 1.426 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.048005 | 1.319 |
| R-HSA-8849473 | PTK6 Expression | 0.059645 | 1.224 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.059645 | 1.224 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.076842 | 1.114 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.082505 | 1.084 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.088134 | 1.055 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.183795 | 0.736 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.193790 | 0.713 |
| R-HSA-390522 | Striated Muscle Contraction | 0.218252 | 0.661 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.114278 | 0.942 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.114278 | 0.942 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.106380 | 0.973 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.124354 | 0.905 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.089208 | 1.050 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.251269 | 0.600 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.121194 | 0.917 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.237291 | 0.625 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.260446 | 0.584 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.158266 | 0.801 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.051086 | 1.292 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.260446 | 0.584 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.149336 | 0.826 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.260473 | 0.584 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.088134 | 1.055 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.158266 | 0.801 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.188808 | 0.724 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.131948 | 0.880 |
| R-HSA-9646399 | Aggrephagy | 0.251269 | 0.600 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.061122 | 1.214 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.076842 | 1.114 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.102394 | 0.990 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.071145 | 1.148 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.082505 | 1.084 |
| R-HSA-191859 | snRNP Assembly | 0.064438 | 1.191 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.064438 | 1.191 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.067813 | 1.169 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.223055 | 0.652 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.198743 | 0.702 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.091370 | 1.039 |
| R-HSA-182971 | EGFR downregulation | 0.203665 | 0.691 |
| R-HSA-167172 | Transcription of the HIV genome | 0.080067 | 1.097 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.059645 | 1.224 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.071145 | 1.148 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.054677 | 1.262 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.193790 | 0.713 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.048005 | 1.319 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.082505 | 1.084 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.087355 | 1.059 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.170855 | 0.767 |
| R-HSA-68886 | M Phase | 0.103293 | 0.986 |
| R-HSA-397014 | Muscle contraction | 0.055409 | 1.256 |
| R-HSA-114608 | Platelet degranulation | 0.057689 | 1.239 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.091072 | 1.041 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.260446 | 0.584 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.157682 | 0.802 |
| R-HSA-9612973 | Autophagy | 0.092569 | 1.034 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.115767 | 0.936 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.213419 | 0.671 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.264992 | 0.577 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.061122 | 1.214 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.218252 | 0.661 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.213419 | 0.671 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.163435 | 0.787 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.069523 | 1.158 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.193790 | 0.713 |
| R-HSA-3371511 | HSF1 activation | 0.232575 | 0.633 |
| R-HSA-9663891 | Selective autophagy | 0.120298 | 0.920 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.064675 | 1.189 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.255871 | 0.592 |
| R-HSA-3214847 | HATs acetylate histones | 0.147216 | 0.832 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.157877 | 0.802 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.177410 | 0.751 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.110308 | 0.957 |
| R-HSA-977347 | Serine metabolism | 0.153067 | 0.815 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.232575 | 0.633 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.092947 | 1.032 |
| R-HSA-168255 | Influenza Infection | 0.123215 | 0.909 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.146868 | 0.833 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.093728 | 1.028 |
| R-HSA-418990 | Adherens junctions interactions | 0.180975 | 0.742 |
| R-HSA-162906 | HIV Infection | 0.066523 | 1.177 |
| R-HSA-421270 | Cell-cell junction organization | 0.233098 | 0.632 |
| R-HSA-419037 | NCAM1 interactions | 0.237291 | 0.625 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.115232 | 0.938 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.115232 | 0.938 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.195074 | 0.710 |
| R-HSA-1632852 | Macroautophagy | 0.074202 | 1.130 |
| R-HSA-68882 | Mitotic Anaphase | 0.177926 | 0.750 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.208466 | 0.681 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.110308 | 0.957 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.137276 | 0.862 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.147835 | 0.830 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.179449 | 0.746 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.142572 | 0.846 |
| R-HSA-180024 | DARPP-32 events | 0.193790 | 0.713 |
| R-HSA-9664873 | Pexophagy | 0.076842 | 1.114 |
| R-HSA-435354 | Zinc transporters | 0.104815 | 0.980 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.153067 | 0.815 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.158266 | 0.801 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.188808 | 0.724 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.193790 | 0.713 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.223055 | 0.652 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.153595 | 0.814 |
| R-HSA-3371556 | Cellular response to heat stress | 0.051086 | 1.292 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.213419 | 0.671 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.255871 | 0.592 |
| R-HSA-70268 | Pyruvate metabolism | 0.118282 | 0.927 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.092947 | 1.032 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.178751 | 0.748 |
| R-HSA-202433 | Generation of second messenger molecules | 0.251269 | 0.600 |
| R-HSA-68875 | Mitotic Prophase | 0.199526 | 0.700 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.205858 | 0.686 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.192853 | 0.715 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.113069 | 0.947 |
| R-HSA-4839726 | Chromatin organization | 0.229858 | 0.639 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.196431 | 0.707 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.227830 | 0.642 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.258200 | 0.588 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.188808 | 0.724 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.116276 | 0.935 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.269511 | 0.569 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.181803 | 0.740 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.232575 | 0.633 |
| R-HSA-1266738 | Developmental Biology | 0.225195 | 0.647 |
| R-HSA-211000 | Gene Silencing by RNA | 0.166508 | 0.779 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.269511 | 0.569 |
| R-HSA-422475 | Axon guidance | 0.268942 | 0.570 |
| R-HSA-73894 | DNA Repair | 0.206405 | 0.685 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.270899 | 0.567 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.073693 | 1.133 |
| R-HSA-5683826 | Surfactant metabolism | 0.274003 | 0.562 |
| R-HSA-373752 | Netrin-1 signaling | 0.274003 | 0.562 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.276384 | 0.558 |
| R-HSA-446728 | Cell junction organization | 0.277552 | 0.557 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.278467 | 0.555 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.278467 | 0.555 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.282904 | 0.548 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.282904 | 0.548 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.282904 | 0.548 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.282904 | 0.548 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.282904 | 0.548 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.282904 | 0.548 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.285472 | 0.544 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.285472 | 0.544 |
| R-HSA-437239 | Recycling pathway of L1 | 0.287314 | 0.542 |
| R-HSA-5620924 | Intraflagellar transport | 0.291697 | 0.535 |
| R-HSA-425410 | Metal ion SLC transporters | 0.291697 | 0.535 |
| R-HSA-9610379 | HCMV Late Events | 0.292282 | 0.534 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.293824 | 0.532 |
| R-HSA-9766229 | Degradation of CDH1 | 0.296054 | 0.529 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.296054 | 0.529 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.299083 | 0.524 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.304687 | 0.516 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.305988 | 0.514 |
| R-HSA-9675108 | Nervous system development | 0.313056 | 0.504 |
| R-HSA-5619102 | SLC transporter disorders | 0.314913 | 0.502 |
| R-HSA-72649 | Translation initiation complex formation | 0.317441 | 0.498 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.317441 | 0.498 |
| R-HSA-72306 | tRNA processing | 0.323926 | 0.490 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.325815 | 0.487 |
| R-HSA-177929 | Signaling by EGFR | 0.325815 | 0.487 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.325815 | 0.487 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.329964 | 0.482 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.334087 | 0.476 |
| R-HSA-1500931 | Cell-Cell communication | 0.341279 | 0.467 |
| R-HSA-983189 | Kinesins | 0.342259 | 0.466 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.342259 | 0.466 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.342259 | 0.466 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.342259 | 0.466 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.342259 | 0.466 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.342259 | 0.466 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.342259 | 0.466 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.349996 | 0.456 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.350331 | 0.456 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.353035 | 0.452 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.354331 | 0.451 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.354331 | 0.451 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.354331 | 0.451 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.354331 | 0.451 |
| R-HSA-8848021 | Signaling by PTK6 | 0.354331 | 0.451 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.362256 | 0.441 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.362256 | 0.441 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.366183 | 0.436 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.366183 | 0.436 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.370086 | 0.432 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.373965 | 0.427 |
| R-HSA-9609690 | HCMV Early Events | 0.381642 | 0.418 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.381652 | 0.418 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.384808 | 0.415 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.385460 | 0.414 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.385460 | 0.414 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.385460 | 0.414 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.385460 | 0.414 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.389245 | 0.410 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.393007 | 0.406 |
| R-HSA-199991 | Membrane Trafficking | 0.393664 | 0.405 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.396436 | 0.402 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.396850 | 0.401 |
| R-HSA-380287 | Centrosome maturation | 0.400463 | 0.397 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.404156 | 0.393 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.404156 | 0.393 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.411476 | 0.386 |
| R-HSA-162582 | Signal Transduction | 0.413265 | 0.384 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.418707 | 0.378 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.418707 | 0.378 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.418707 | 0.378 |
| R-HSA-6806834 | Signaling by MET | 0.418707 | 0.378 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.420399 | 0.376 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.422290 | 0.374 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.427264 | 0.369 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.432906 | 0.364 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.436402 | 0.360 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.436402 | 0.360 |
| R-HSA-8951664 | Neddylation | 0.437236 | 0.359 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.443330 | 0.353 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.450173 | 0.347 |
| R-HSA-156902 | Peptide chain elongation | 0.450173 | 0.347 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.460282 | 0.337 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.463611 | 0.334 |
| R-HSA-1640170 | Cell Cycle | 0.466560 | 0.331 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.466919 | 0.331 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.476724 | 0.322 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.479952 | 0.319 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.479952 | 0.319 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.483161 | 0.316 |
| R-HSA-190236 | Signaling by FGFR | 0.489519 | 0.310 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.490073 | 0.310 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.492669 | 0.307 |
| R-HSA-9609646 | HCMV Infection | 0.495972 | 0.305 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.498912 | 0.302 |
| R-HSA-192823 | Viral mRNA Translation | 0.505078 | 0.297 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.508133 | 0.294 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.508133 | 0.294 |
| R-HSA-111885 | Opioid Signalling | 0.508133 | 0.294 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.511493 | 0.291 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.517187 | 0.286 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.520168 | 0.284 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.523131 | 0.281 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.523131 | 0.281 |
| R-HSA-202403 | TCR signaling | 0.529002 | 0.277 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.534802 | 0.272 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.534802 | 0.272 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.540531 | 0.267 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.546191 | 0.263 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.548995 | 0.260 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.550738 | 0.259 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.551781 | 0.258 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.551781 | 0.258 |
| R-HSA-373760 | L1CAM interactions | 0.551781 | 0.258 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.556164 | 0.255 |
| R-HSA-5693538 | Homology Directed Repair | 0.557303 | 0.254 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.560039 | 0.252 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.565460 | 0.248 |
| R-HSA-6798695 | Neutrophil degranulation | 0.566174 | 0.247 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.570816 | 0.244 |
| R-HSA-74160 | Gene expression (Transcription) | 0.574152 | 0.241 |
| R-HSA-194138 | Signaling by VEGF | 0.578726 | 0.238 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.581293 | 0.236 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.591591 | 0.228 |
| R-HSA-5576891 | Cardiac conduction | 0.596628 | 0.224 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.599123 | 0.222 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.616166 | 0.210 |
| R-HSA-9664407 | Parasite infection | 0.620902 | 0.207 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.620902 | 0.207 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.620902 | 0.207 |
| R-HSA-2262752 | Cellular responses to stress | 0.621352 | 0.207 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.623248 | 0.205 |
| R-HSA-1474244 | Extracellular matrix organization | 0.638235 | 0.195 |
| R-HSA-2187338 | Visual phototransduction | 0.639275 | 0.194 |
| R-HSA-69242 | S Phase | 0.641509 | 0.193 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.650308 | 0.187 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.653466 | 0.185 |
| R-HSA-9711097 | Cellular response to starvation | 0.663107 | 0.178 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.675443 | 0.170 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.689270 | 0.162 |
| R-HSA-418555 | G alpha (s) signalling events | 0.691197 | 0.160 |
| R-HSA-9679506 | SARS-CoV Infections | 0.691804 | 0.160 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.693112 | 0.159 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.695016 | 0.158 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.696907 | 0.157 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.698788 | 0.156 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.698788 | 0.156 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.713253 | 0.147 |
| R-HSA-913531 | Interferon Signaling | 0.713253 | 0.147 |
| R-HSA-69275 | G2/M Transition | 0.718723 | 0.143 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.722205 | 0.141 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.722205 | 0.141 |
| R-HSA-109582 | Hemostasis | 0.734901 | 0.134 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.742216 | 0.129 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.742216 | 0.129 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.752391 | 0.124 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.782174 | 0.107 |
| R-HSA-72312 | rRNA processing | 0.790185 | 0.102 |
| R-HSA-1280218 | Adaptive Immune System | 0.792480 | 0.101 |
| R-HSA-157118 | Signaling by NOTCH | 0.800413 | 0.097 |
| R-HSA-112316 | Neuronal System | 0.806373 | 0.093 |
| R-HSA-5688426 | Deubiquitination | 0.818279 | 0.087 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.819412 | 0.086 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.839746 | 0.076 |
| R-HSA-9824446 | Viral Infection Pathways | 0.842166 | 0.075 |
| R-HSA-9658195 | Leishmania infection | 0.845574 | 0.073 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.845574 | 0.073 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.853125 | 0.069 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.859431 | 0.066 |
| R-HSA-212436 | Generic Transcription Pathway | 0.860985 | 0.065 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.881343 | 0.055 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.897961 | 0.047 |
| R-HSA-8953854 | Metabolism of RNA | 0.902074 | 0.045 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.907556 | 0.042 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.908316 | 0.042 |
| R-HSA-5663205 | Infectious disease | 0.912114 | 0.040 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.922664 | 0.035 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.926006 | 0.033 |
| R-HSA-418594 | G alpha (i) signalling events | 0.930534 | 0.031 |
| R-HSA-72766 | Translation | 0.939551 | 0.027 |
| R-HSA-1643685 | Disease | 0.950066 | 0.022 |
| R-HSA-168249 | Innate Immune System | 0.970622 | 0.013 |
| R-HSA-597592 | Post-translational protein modification | 0.981337 | 0.008 |
| R-HSA-168256 | Immune System | 0.984446 | 0.007 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.992287 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.993345 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.995109 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.996115 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.998271 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999682 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999937 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.850 | 0.694 | 1 | 0.904 |
HIPK2 |
0.841 | 0.722 | 1 | 0.912 |
CDK3 |
0.839 | 0.700 | 1 | 0.936 |
CDK18 |
0.839 | 0.746 | 1 | 0.928 |
CDK1 |
0.836 | 0.743 | 1 | 0.929 |
CDK19 |
0.836 | 0.714 | 1 | 0.924 |
CDK17 |
0.835 | 0.750 | 1 | 0.937 |
CDK5 |
0.835 | 0.731 | 1 | 0.908 |
P38G |
0.834 | 0.756 | 1 | 0.942 |
CDK8 |
0.832 | 0.711 | 1 | 0.914 |
CDK7 |
0.831 | 0.707 | 1 | 0.925 |
CLK3 |
0.831 | 0.526 | 1 | 0.722 |
JNK2 |
0.830 | 0.758 | 1 | 0.941 |
ERK1 |
0.829 | 0.729 | 1 | 0.922 |
P38D |
0.829 | 0.750 | 1 | 0.940 |
HIPK4 |
0.827 | 0.522 | 1 | 0.738 |
DYRK2 |
0.827 | 0.683 | 1 | 0.879 |
CDK16 |
0.826 | 0.725 | 1 | 0.925 |
P38B |
0.824 | 0.734 | 1 | 0.911 |
CDK13 |
0.824 | 0.700 | 1 | 0.928 |
CDK10 |
0.824 | 0.695 | 1 | 0.924 |
HIPK1 |
0.822 | 0.659 | 1 | 0.865 |
CDK12 |
0.822 | 0.703 | 1 | 0.937 |
JNK3 |
0.822 | 0.741 | 1 | 0.930 |
NLK |
0.821 | 0.678 | 1 | 0.774 |
CDK14 |
0.819 | 0.715 | 1 | 0.916 |
SRPK1 |
0.819 | 0.395 | -3 | 0.796 |
P38A |
0.818 | 0.709 | 1 | 0.889 |
DYRK4 |
0.816 | 0.676 | 1 | 0.930 |
DYRK1A |
0.816 | 0.599 | 1 | 0.874 |
DYRK1B |
0.815 | 0.658 | 1 | 0.910 |
CDK9 |
0.815 | 0.680 | 1 | 0.925 |
ERK2 |
0.812 | 0.703 | 1 | 0.898 |
HIPK3 |
0.812 | 0.631 | 1 | 0.853 |
SRPK2 |
0.812 | 0.339 | -3 | 0.737 |
CDK6 |
0.810 | 0.690 | 1 | 0.922 |
CDK2 |
0.808 | 0.566 | 1 | 0.869 |
ERK5 |
0.808 | 0.371 | 1 | 0.681 |
CDKL5 |
0.805 | 0.257 | -3 | 0.826 |
CDK4 |
0.805 | 0.695 | 1 | 0.934 |
ICK |
0.805 | 0.416 | -3 | 0.853 |
COT |
0.805 | 0.037 | 2 | 0.818 |
CLK1 |
0.805 | 0.410 | -3 | 0.773 |
MAK |
0.804 | 0.541 | -2 | 0.758 |
CLK2 |
0.804 | 0.414 | -3 | 0.787 |
MTOR |
0.803 | 0.243 | 1 | 0.601 |
CDKL1 |
0.801 | 0.242 | -3 | 0.830 |
SRPK3 |
0.800 | 0.307 | -3 | 0.773 |
JNK1 |
0.800 | 0.656 | 1 | 0.936 |
CLK4 |
0.798 | 0.365 | -3 | 0.794 |
DYRK3 |
0.797 | 0.501 | 1 | 0.839 |
PRKD1 |
0.797 | 0.124 | -3 | 0.848 |
MOS |
0.791 | 0.056 | 1 | 0.509 |
PRKD2 |
0.791 | 0.110 | -3 | 0.797 |
NUAK2 |
0.790 | 0.093 | -3 | 0.842 |
PIM3 |
0.790 | 0.063 | -3 | 0.849 |
CDC7 |
0.789 | -0.054 | 1 | 0.471 |
MOK |
0.789 | 0.488 | 1 | 0.773 |
PKN3 |
0.787 | 0.051 | -3 | 0.834 |
NDR2 |
0.787 | 0.040 | -3 | 0.844 |
NEK6 |
0.787 | 0.012 | -2 | 0.849 |
TGFBR2 |
0.787 | 0.013 | -2 | 0.808 |
GCN2 |
0.786 | -0.121 | 2 | 0.743 |
PKCD |
0.785 | 0.073 | 2 | 0.782 |
PKN2 |
0.784 | 0.033 | -3 | 0.832 |
MST4 |
0.784 | 0.030 | 2 | 0.852 |
PRPK |
0.784 | -0.075 | -1 | 0.793 |
PRP4 |
0.783 | 0.378 | -3 | 0.686 |
TBK1 |
0.783 | -0.125 | 1 | 0.418 |
P90RSK |
0.782 | 0.084 | -3 | 0.812 |
RSK2 |
0.781 | 0.068 | -3 | 0.806 |
PKCB |
0.781 | 0.073 | 2 | 0.749 |
ULK2 |
0.781 | -0.138 | 2 | 0.759 |
ATR |
0.781 | -0.015 | 1 | 0.496 |
PIM1 |
0.780 | 0.102 | -3 | 0.808 |
CAMK1B |
0.780 | 0.010 | -3 | 0.848 |
CHAK2 |
0.780 | -0.000 | -1 | 0.779 |
PHKG1 |
0.779 | 0.032 | -3 | 0.823 |
RAF1 |
0.779 | -0.147 | 1 | 0.467 |
RSK3 |
0.779 | 0.048 | -3 | 0.805 |
IKKE |
0.779 | -0.143 | 1 | 0.417 |
NEK7 |
0.779 | -0.100 | -3 | 0.819 |
MAPKAPK3 |
0.779 | 0.032 | -3 | 0.804 |
NDR1 |
0.779 | -0.007 | -3 | 0.838 |
BMPR2 |
0.778 | -0.107 | -2 | 0.859 |
MLK3 |
0.778 | 0.049 | 2 | 0.745 |
NIK |
0.778 | 0.012 | -3 | 0.848 |
MAPKAPK2 |
0.778 | 0.062 | -3 | 0.776 |
PKCA |
0.777 | 0.068 | 2 | 0.747 |
PRKD3 |
0.777 | 0.077 | -3 | 0.783 |
IKKB |
0.777 | -0.148 | -2 | 0.691 |
DSTYK |
0.777 | -0.116 | 2 | 0.820 |
ERK7 |
0.777 | 0.242 | 2 | 0.533 |
MLK1 |
0.777 | -0.067 | 2 | 0.801 |
NUAK1 |
0.777 | 0.045 | -3 | 0.804 |
AMPKA1 |
0.776 | -0.008 | -3 | 0.843 |
WNK1 |
0.776 | -0.063 | -2 | 0.799 |
LATS2 |
0.776 | 0.000 | -5 | 0.629 |
PKCG |
0.775 | 0.049 | 2 | 0.744 |
MLK2 |
0.775 | -0.034 | 2 | 0.798 |
AMPKA2 |
0.774 | 0.018 | -3 | 0.826 |
RIPK3 |
0.774 | -0.118 | 3 | 0.713 |
SKMLCK |
0.773 | -0.022 | -2 | 0.773 |
TSSK1 |
0.773 | 0.012 | -3 | 0.857 |
LATS1 |
0.773 | 0.090 | -3 | 0.855 |
PDHK4 |
0.772 | -0.239 | 1 | 0.517 |
CAMLCK |
0.772 | -0.006 | -2 | 0.760 |
DAPK2 |
0.772 | -0.006 | -3 | 0.854 |
NEK9 |
0.772 | -0.115 | 2 | 0.816 |
ULK1 |
0.771 | -0.155 | -3 | 0.774 |
IRE1 |
0.771 | -0.049 | 1 | 0.432 |
P70S6KB |
0.770 | 0.025 | -3 | 0.811 |
PKCZ |
0.770 | 0.012 | 2 | 0.775 |
AURC |
0.770 | 0.004 | -2 | 0.548 |
MARK4 |
0.769 | -0.060 | 4 | 0.765 |
IRE2 |
0.769 | -0.019 | 2 | 0.762 |
MNK1 |
0.769 | 0.016 | -2 | 0.707 |
PDHK1 |
0.769 | -0.219 | 1 | 0.489 |
MASTL |
0.768 | -0.139 | -2 | 0.771 |
MNK2 |
0.767 | -0.029 | -2 | 0.695 |
AKT2 |
0.767 | 0.089 | -3 | 0.738 |
PKCH |
0.767 | 0.015 | 2 | 0.734 |
CAMK2D |
0.767 | -0.061 | -3 | 0.830 |
PKACG |
0.767 | -0.024 | -2 | 0.636 |
GRK1 |
0.767 | -0.022 | -2 | 0.746 |
IKKA |
0.767 | -0.102 | -2 | 0.706 |
TSSK2 |
0.766 | -0.043 | -5 | 0.782 |
MPSK1 |
0.766 | 0.130 | 1 | 0.471 |
BMPR1B |
0.766 | -0.011 | 1 | 0.431 |
MELK |
0.766 | -0.023 | -3 | 0.813 |
NIM1 |
0.766 | -0.070 | 3 | 0.737 |
ANKRD3 |
0.765 | -0.133 | 1 | 0.489 |
RSK4 |
0.765 | 0.062 | -3 | 0.790 |
CAMK2G |
0.765 | -0.155 | 2 | 0.696 |
GRK7 |
0.765 | 0.017 | 1 | 0.461 |
GRK5 |
0.765 | -0.165 | -3 | 0.795 |
YSK4 |
0.764 | -0.085 | 1 | 0.438 |
DLK |
0.764 | -0.151 | 1 | 0.475 |
HUNK |
0.764 | -0.174 | 2 | 0.766 |
QSK |
0.763 | -0.008 | 4 | 0.749 |
WNK3 |
0.763 | -0.220 | 1 | 0.459 |
SGK3 |
0.763 | 0.033 | -3 | 0.793 |
CHAK1 |
0.763 | -0.062 | 2 | 0.777 |
PKR |
0.763 | -0.039 | 1 | 0.469 |
MLK4 |
0.762 | -0.055 | 2 | 0.706 |
VRK2 |
0.761 | 0.050 | 1 | 0.539 |
PIM2 |
0.761 | 0.084 | -3 | 0.780 |
SIK |
0.761 | -0.003 | -3 | 0.780 |
CAMK4 |
0.761 | -0.091 | -3 | 0.811 |
ALK4 |
0.761 | -0.056 | -2 | 0.806 |
BCKDK |
0.760 | -0.190 | -1 | 0.724 |
DCAMKL1 |
0.760 | 0.023 | -3 | 0.805 |
TGFBR1 |
0.760 | -0.050 | -2 | 0.793 |
PLK1 |
0.760 | -0.094 | -2 | 0.831 |
PKCT |
0.760 | 0.017 | 2 | 0.741 |
RIPK1 |
0.759 | -0.204 | 1 | 0.447 |
QIK |
0.759 | -0.081 | -3 | 0.820 |
MST3 |
0.759 | 0.035 | 2 | 0.840 |
PKACB |
0.759 | 0.023 | -2 | 0.566 |
BRSK2 |
0.759 | -0.056 | -3 | 0.808 |
MSK2 |
0.758 | -0.014 | -3 | 0.790 |
PAK3 |
0.758 | -0.088 | -2 | 0.679 |
CAMK2A |
0.758 | -0.006 | 2 | 0.668 |
PKG2 |
0.758 | -0.008 | -2 | 0.566 |
TTBK2 |
0.758 | -0.176 | 2 | 0.663 |
PHKG2 |
0.757 | -0.018 | -3 | 0.791 |
ATM |
0.757 | -0.089 | 1 | 0.450 |
NEK2 |
0.757 | -0.120 | 2 | 0.804 |
ACVR2B |
0.757 | -0.051 | -2 | 0.813 |
PAK1 |
0.757 | -0.068 | -2 | 0.683 |
PINK1 |
0.757 | 0.107 | 1 | 0.610 |
PKCE |
0.757 | 0.076 | 2 | 0.744 |
BRSK1 |
0.755 | -0.036 | -3 | 0.809 |
CAMK2B |
0.755 | -0.054 | 2 | 0.637 |
AKT1 |
0.755 | 0.053 | -3 | 0.752 |
PLK4 |
0.755 | -0.100 | 2 | 0.594 |
TAO3 |
0.755 | 0.020 | 1 | 0.487 |
AURB |
0.755 | -0.038 | -2 | 0.542 |
GSK3A |
0.755 | 0.144 | 4 | 0.365 |
ACVR2A |
0.755 | -0.057 | -2 | 0.807 |
GRK6 |
0.754 | -0.175 | 1 | 0.460 |
MEK1 |
0.754 | -0.146 | 2 | 0.784 |
HRI |
0.754 | -0.096 | -2 | 0.842 |
PERK |
0.754 | -0.085 | -2 | 0.832 |
NEK5 |
0.754 | -0.074 | 1 | 0.453 |
PKCI |
0.753 | 0.007 | 2 | 0.752 |
CAMK1G |
0.753 | -0.007 | -3 | 0.785 |
CHK1 |
0.753 | -0.048 | -3 | 0.822 |
MARK3 |
0.752 | -0.038 | 4 | 0.710 |
PKN1 |
0.752 | 0.042 | -3 | 0.760 |
SMG1 |
0.752 | -0.090 | 1 | 0.461 |
ZAK |
0.752 | -0.101 | 1 | 0.445 |
IRAK4 |
0.752 | -0.082 | 1 | 0.412 |
GRK4 |
0.752 | -0.192 | -2 | 0.798 |
DNAPK |
0.751 | -0.068 | 1 | 0.467 |
MSK1 |
0.751 | -0.012 | -3 | 0.792 |
TLK2 |
0.751 | -0.129 | 1 | 0.444 |
DCAMKL2 |
0.751 | -0.017 | -3 | 0.812 |
PRKX |
0.751 | 0.041 | -3 | 0.725 |
BUB1 |
0.750 | 0.099 | -5 | 0.735 |
MEK5 |
0.750 | -0.122 | 2 | 0.791 |
SSTK |
0.750 | -0.028 | 4 | 0.737 |
MYLK4 |
0.750 | -0.044 | -2 | 0.661 |
MAPKAPK5 |
0.749 | -0.050 | -3 | 0.772 |
PAK6 |
0.749 | -0.060 | -2 | 0.587 |
DRAK1 |
0.749 | -0.114 | 1 | 0.463 |
NEK11 |
0.749 | -0.058 | 1 | 0.489 |
CK1E |
0.749 | -0.009 | -3 | 0.513 |
MEKK2 |
0.749 | -0.088 | 2 | 0.775 |
MEKK1 |
0.749 | -0.135 | 1 | 0.461 |
MARK2 |
0.748 | -0.068 | 4 | 0.684 |
P70S6K |
0.747 | 0.018 | -3 | 0.754 |
SNRK |
0.747 | -0.148 | 2 | 0.658 |
PAK2 |
0.746 | -0.109 | -2 | 0.664 |
MAP3K15 |
0.746 | -0.007 | 1 | 0.456 |
MEKK3 |
0.746 | -0.144 | 1 | 0.469 |
AKT3 |
0.746 | 0.068 | -3 | 0.698 |
GRK2 |
0.746 | -0.084 | -2 | 0.668 |
GCK |
0.746 | 0.011 | 1 | 0.479 |
WNK4 |
0.746 | -0.127 | -2 | 0.790 |
ALK2 |
0.745 | -0.098 | -2 | 0.796 |
PDK1 |
0.745 | -0.012 | 1 | 0.493 |
TAO2 |
0.744 | -0.018 | 2 | 0.832 |
TNIK |
0.744 | 0.046 | 3 | 0.881 |
NEK8 |
0.744 | -0.090 | 2 | 0.809 |
MEKK6 |
0.744 | -0.033 | 1 | 0.459 |
HGK |
0.744 | 0.008 | 3 | 0.877 |
PLK3 |
0.744 | -0.130 | 2 | 0.670 |
PASK |
0.743 | 0.008 | -3 | 0.859 |
BMPR1A |
0.743 | -0.059 | 1 | 0.419 |
FAM20C |
0.743 | -0.079 | 2 | 0.473 |
TLK1 |
0.743 | -0.129 | -2 | 0.828 |
CK1D |
0.743 | 0.016 | -3 | 0.460 |
SMMLCK |
0.743 | -0.029 | -3 | 0.824 |
CHK2 |
0.743 | 0.052 | -3 | 0.691 |
AURA |
0.742 | -0.065 | -2 | 0.516 |
LKB1 |
0.742 | -0.020 | -3 | 0.790 |
KHS1 |
0.741 | 0.038 | 1 | 0.451 |
SGK1 |
0.741 | 0.080 | -3 | 0.682 |
MST2 |
0.741 | -0.063 | 1 | 0.457 |
MARK1 |
0.741 | -0.091 | 4 | 0.723 |
MINK |
0.740 | -0.032 | 1 | 0.441 |
SBK |
0.740 | 0.153 | -3 | 0.642 |
EEF2K |
0.740 | -0.002 | 3 | 0.834 |
KHS2 |
0.740 | 0.045 | 1 | 0.473 |
NEK4 |
0.740 | -0.094 | 1 | 0.432 |
GSK3B |
0.740 | 0.003 | 4 | 0.353 |
PKACA |
0.739 | -0.001 | -2 | 0.512 |
BRAF |
0.739 | -0.161 | -4 | 0.821 |
GAK |
0.739 | -0.023 | 1 | 0.488 |
HPK1 |
0.739 | -0.019 | 1 | 0.470 |
CK1G1 |
0.739 | -0.055 | -3 | 0.502 |
LOK |
0.737 | -0.034 | -2 | 0.707 |
CAMK1D |
0.737 | 0.002 | -3 | 0.721 |
PBK |
0.737 | -0.000 | 1 | 0.451 |
CAMK1A |
0.737 | 0.035 | -3 | 0.707 |
ROCK2 |
0.736 | 0.030 | -3 | 0.804 |
NEK1 |
0.735 | -0.071 | 1 | 0.430 |
LRRK2 |
0.735 | -0.010 | 2 | 0.816 |
CK1A2 |
0.734 | -0.021 | -3 | 0.465 |
MRCKA |
0.734 | 0.010 | -3 | 0.773 |
MRCKB |
0.734 | 0.017 | -3 | 0.762 |
MST1 |
0.733 | -0.057 | 1 | 0.445 |
DAPK3 |
0.733 | -0.027 | -3 | 0.812 |
PAK5 |
0.733 | -0.083 | -2 | 0.530 |
SLK |
0.732 | -0.048 | -2 | 0.665 |
HASPIN |
0.732 | 0.034 | -1 | 0.633 |
CAMKK2 |
0.731 | -0.145 | -2 | 0.701 |
YSK1 |
0.731 | -0.057 | 2 | 0.808 |
VRK1 |
0.730 | -0.117 | 2 | 0.817 |
TTBK1 |
0.730 | -0.185 | 2 | 0.587 |
CAMKK1 |
0.730 | -0.197 | -2 | 0.710 |
TAK1 |
0.729 | -0.128 | 1 | 0.457 |
GRK3 |
0.729 | -0.095 | -2 | 0.622 |
PAK4 |
0.728 | -0.079 | -2 | 0.541 |
OSR1 |
0.728 | -0.016 | 2 | 0.776 |
IRAK1 |
0.728 | -0.240 | -1 | 0.671 |
PDHK3_TYR |
0.727 | 0.139 | 4 | 0.812 |
LIMK2_TYR |
0.726 | 0.174 | -3 | 0.846 |
NEK3 |
0.725 | -0.103 | 1 | 0.443 |
TTK |
0.725 | 0.011 | -2 | 0.845 |
DMPK1 |
0.725 | 0.046 | -3 | 0.775 |
DAPK1 |
0.725 | -0.040 | -3 | 0.800 |
CRIK |
0.724 | 0.061 | -3 | 0.755 |
RIPK2 |
0.722 | -0.206 | 1 | 0.427 |
TESK1_TYR |
0.722 | 0.083 | 3 | 0.850 |
PKMYT1_TYR |
0.722 | 0.129 | 3 | 0.824 |
AAK1 |
0.722 | 0.049 | 1 | 0.384 |
BIKE |
0.721 | -0.007 | 1 | 0.422 |
ROCK1 |
0.721 | 0.007 | -3 | 0.774 |
MYO3A |
0.720 | -0.006 | 1 | 0.446 |
MEK2 |
0.720 | -0.200 | 2 | 0.770 |
CK2A2 |
0.720 | -0.096 | 1 | 0.401 |
STK33 |
0.720 | -0.146 | 2 | 0.577 |
MYO3B |
0.719 | -0.018 | 2 | 0.827 |
PDHK4_TYR |
0.719 | 0.059 | 2 | 0.810 |
TAO1 |
0.718 | -0.051 | 1 | 0.437 |
ASK1 |
0.718 | -0.064 | 1 | 0.444 |
MAP2K4_TYR |
0.718 | 0.019 | -1 | 0.807 |
PKG1 |
0.717 | -0.044 | -2 | 0.476 |
PLK2 |
0.716 | -0.095 | -3 | 0.732 |
MAP2K6_TYR |
0.715 | 0.010 | -1 | 0.808 |
MAP2K7_TYR |
0.714 | -0.103 | 2 | 0.802 |
BMPR2_TYR |
0.713 | -0.007 | -1 | 0.801 |
PINK1_TYR |
0.713 | -0.090 | 1 | 0.502 |
PDHK1_TYR |
0.712 | -0.040 | -1 | 0.820 |
ROS1 |
0.712 | -0.050 | 3 | 0.785 |
LIMK1_TYR |
0.712 | 0.012 | 2 | 0.819 |
RET |
0.710 | -0.106 | 1 | 0.466 |
CSF1R |
0.710 | -0.053 | 3 | 0.794 |
JAK2 |
0.710 | -0.072 | 1 | 0.466 |
JAK1 |
0.709 | -0.008 | 1 | 0.438 |
MST1R |
0.708 | -0.093 | 3 | 0.807 |
TYRO3 |
0.708 | -0.113 | 3 | 0.815 |
CK2A1 |
0.708 | -0.112 | 1 | 0.392 |
TYK2 |
0.708 | -0.138 | 1 | 0.448 |
LCK |
0.707 | -0.024 | -1 | 0.770 |
CK1A |
0.706 | -0.026 | -3 | 0.377 |
TXK |
0.706 | -0.038 | 1 | 0.449 |
JAK3 |
0.706 | -0.085 | 1 | 0.463 |
EPHA6 |
0.705 | -0.094 | -1 | 0.787 |
YES1 |
0.704 | -0.069 | -1 | 0.797 |
EPHB4 |
0.704 | -0.108 | -1 | 0.765 |
TNNI3K_TYR |
0.704 | -0.011 | 1 | 0.455 |
FGR |
0.704 | -0.086 | 1 | 0.446 |
ABL2 |
0.703 | -0.086 | -1 | 0.722 |
TNK1 |
0.702 | -0.044 | 3 | 0.789 |
NEK10_TYR |
0.702 | -0.069 | 1 | 0.410 |
BLK |
0.702 | -0.037 | -1 | 0.772 |
ALPHAK3 |
0.701 | -0.109 | -1 | 0.697 |
TNK2 |
0.701 | -0.089 | 3 | 0.748 |
HCK |
0.700 | -0.103 | -1 | 0.764 |
INSRR |
0.700 | -0.109 | 3 | 0.733 |
KDR |
0.700 | -0.068 | 3 | 0.748 |
ABL1 |
0.699 | -0.097 | -1 | 0.716 |
DDR1 |
0.699 | -0.151 | 4 | 0.731 |
ITK |
0.699 | -0.103 | -1 | 0.721 |
STLK3 |
0.699 | -0.167 | 1 | 0.422 |
YANK3 |
0.698 | -0.078 | 2 | 0.351 |
KIT |
0.698 | -0.109 | 3 | 0.787 |
FLT3 |
0.696 | -0.147 | 3 | 0.813 |
TEK |
0.696 | -0.054 | 3 | 0.742 |
FGFR1 |
0.695 | -0.074 | 3 | 0.756 |
PDGFRB |
0.695 | -0.178 | 3 | 0.803 |
FGFR2 |
0.693 | -0.102 | 3 | 0.758 |
MET |
0.693 | -0.104 | 3 | 0.779 |
BMX |
0.691 | -0.101 | -1 | 0.645 |
FYN |
0.691 | -0.055 | -1 | 0.765 |
PDGFRA |
0.691 | -0.181 | 3 | 0.811 |
FER |
0.690 | -0.207 | 1 | 0.455 |
WEE1_TYR |
0.690 | -0.073 | -1 | 0.672 |
DDR2 |
0.690 | -0.033 | 3 | 0.709 |
EPHB1 |
0.689 | -0.185 | 1 | 0.444 |
MERTK |
0.689 | -0.162 | 3 | 0.764 |
EPHA4 |
0.689 | -0.123 | 2 | 0.679 |
SRMS |
0.689 | -0.185 | 1 | 0.434 |
EPHB2 |
0.688 | -0.157 | -1 | 0.743 |
AXL |
0.688 | -0.185 | 3 | 0.765 |
ALK |
0.687 | -0.150 | 3 | 0.717 |
FLT1 |
0.687 | -0.109 | -1 | 0.757 |
EPHB3 |
0.687 | -0.183 | -1 | 0.750 |
TEC |
0.686 | -0.145 | -1 | 0.661 |
FGFR3 |
0.685 | -0.100 | 3 | 0.730 |
INSR |
0.684 | -0.156 | 3 | 0.722 |
FRK |
0.684 | -0.145 | -1 | 0.760 |
BTK |
0.684 | -0.211 | -1 | 0.687 |
ERBB2 |
0.682 | -0.173 | 1 | 0.433 |
LYN |
0.681 | -0.134 | 3 | 0.721 |
FLT4 |
0.681 | -0.165 | 3 | 0.734 |
NTRK1 |
0.681 | -0.224 | -1 | 0.743 |
PTK2B |
0.681 | -0.115 | -1 | 0.701 |
SRC |
0.680 | -0.103 | -1 | 0.760 |
NTRK2 |
0.680 | -0.214 | 3 | 0.742 |
LTK |
0.680 | -0.184 | 3 | 0.731 |
PTK6 |
0.679 | -0.211 | -1 | 0.659 |
EPHA1 |
0.679 | -0.181 | 3 | 0.770 |
EPHA7 |
0.678 | -0.161 | 2 | 0.691 |
NTRK3 |
0.677 | -0.169 | -1 | 0.702 |
MUSK |
0.676 | -0.129 | 1 | 0.369 |
EGFR |
0.676 | -0.120 | 1 | 0.376 |
MATK |
0.674 | -0.130 | -1 | 0.651 |
PTK2 |
0.674 | -0.056 | -1 | 0.739 |
EPHA3 |
0.674 | -0.187 | 2 | 0.658 |
CK1G3 |
0.673 | -0.059 | -3 | 0.333 |
SYK |
0.671 | -0.075 | -1 | 0.715 |
EPHA8 |
0.670 | -0.150 | -1 | 0.736 |
FGFR4 |
0.669 | -0.135 | -1 | 0.694 |
EPHA5 |
0.668 | -0.185 | 2 | 0.656 |
IGF1R |
0.666 | -0.158 | 3 | 0.657 |
CSK |
0.666 | -0.191 | 2 | 0.697 |
YANK2 |
0.664 | -0.099 | 2 | 0.360 |
ZAP70 |
0.662 | -0.056 | -1 | 0.630 |
ERBB4 |
0.662 | -0.113 | 1 | 0.369 |
EPHA2 |
0.661 | -0.161 | -1 | 0.697 |
CK1G2 |
0.656 | -0.067 | -3 | 0.422 |
FES |
0.650 | -0.178 | -1 | 0.630 |