Motif 769 (n=158)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NMY6 | ANXA2P2 | S134 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A7KAX9 | ARHGAP32 | S1630 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| E7EQ34 | None | T117 | ochoa | Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) | Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037078, ECO:0000256|PIRNR:PIRNR028865}. |
| O14653 | GOSR2 | T117 | ochoa | Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) | Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}. |
| O14715 | RGPD8 | S1294 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14879 | IFIT3 | S270 | ochoa | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}. |
| O15027 | SEC16A | S526 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15350 | TP73 | S388 | psp | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O15400 | STX7 | S205 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O43399 | TPD52L2 | Y106 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43491 | EPB41L2 | S627 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43586 | PSTPIP1 | S327 | ochoa | Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) | Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. {ECO:0000250, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}. |
| O75469 | NR1I2 | S167 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O75716 | STK16 | S197 | psp | Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK) | Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {ECO:0000269|PubMed:10364453}. |
| O75815 | BCAR3 | S471 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O94979 | SEC31A | S1163 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95466 | FMNL1 | S685 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95714 | HERC2 | S2010 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95831 | AIFM1 | S249 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P01241 | GH1 | S132 | psp | Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone) | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
| P06733 | ENO1 | S272 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07199 | CENPB | S307 | ochoa | Major centromere autoantigen B (Centromere protein B) (CENP-B) | Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). {ECO:0000269|PubMed:11726497, ECO:0000305}. |
| P07355 | ANXA2 | S134 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08567 | PLEK | S113 | psp | Pleckstrin (Platelet 47 kDa protein) (p47) | Major protein kinase C substrate of platelets. |
| P0C7T5 | ATXN1L | S292 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P11055 | MYH3 | S739 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11171 | EPB41 | S664 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12882 | MYH1 | S742 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S738 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12956 | XRCC6 | S51 | psp | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P12956 | XRCC6 | S222 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P13535 | MYH8 | S741 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14416 | DRD2 | S229 | psp | D(2) dopamine receptor (Dopamine D2 receptor) | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000269|PubMed:21645528}. |
| P17661 | DES | S82 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P18206 | VCL | S101 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P22059 | OSBP | S200 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P24043 | LAMA2 | S2502 | ochoa | Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P25090 | FPR2 | S236 | psp | N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP) | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts as a receptor for humanin (PubMed:15465011). {ECO:0000250|UniProtKB:O88536, ECO:0000269|PubMed:1374236, ECO:0000269|PubMed:15465011, ECO:0000269|PubMed:9547339}. |
| P35612 | ADD2 | S60 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P35749 | MYH11 | S1161 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P40855 | PEX19 | S146 | ochoa | Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
| P42330 | AKR1C3 | S121 | ochoa | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
| P49662 | CASP4 | S279 | ochoa | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:23516580, PubMed:26375003, PubMed:32109412, PubMed:7797510). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:32109412, PubMed:37993712, PubMed:37993714, PubMed:7797510). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B (PubMed:25119034, PubMed:25121752, PubMed:26375003, PubMed:31268602, PubMed:32109412, PubMed:37993712, PubMed:37993714). In the non-canonical inflammasome, CASP4 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor (PubMed:25119034, PubMed:25121752, PubMed:29520027, PubMed:32510692, PubMed:32581219, PubMed:37993712). LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:25119034, PubMed:25121752, PubMed:37993712, PubMed:37993714). Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412). Involved in NLRP3-dependent CASP1 activation and IL1B secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:22246630, PubMed:23516580, PubMed:24879791, PubMed:25964352, PubMed:26173988, PubMed:26174085, PubMed:26508369). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B secretion (PubMed:33377178). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752, PubMed:25964352, PubMed:26375003). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (By similarity). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found in Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Catalyzes cleavage and maturation of IL18; IL18 processing also depends of the exosite interface on CASP4 (PubMed:15326478, PubMed:37993712, PubMed:37993714). In contrast, it does not directly process IL1B (PubMed:7743998, PubMed:7797510, PubMed:7797592). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000250|UniProtKB:P70343, ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:24879791, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:25121752, ECO:0000269|PubMed:25964352, ECO:0000269|PubMed:26173988, ECO:0000269|PubMed:26174085, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26508369, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29520027, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32510692, ECO:0000269|PubMed:32581219, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:37001519, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7743998, ECO:0000269|PubMed:7797510, ECO:0000269|PubMed:7797592}.; FUNCTION: (Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts. {ECO:0000269|PubMed:29077095}. |
| P49748 | ACADVL | S522 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P49815 | TSC2 | S960 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P51955 | NEK2 | S296 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P52564 | MAP2K6 | S26 | ochoa | Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393, ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669, ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9218798}. |
| P53350 | PLK1 | S387 | ochoa | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P53621 | COPA | S824 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P55201 | BRPF1 | S577 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P55201 | BRPF1 | S1081 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P61978 | HNRNPK | S81 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| Q04656 | ATP7A | S1480 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q07869 | PPARA | S21 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q09666 | AHNAK | S5763 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13370 | PDE3B | S441 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q14202 | ZMYM3 | S1055 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q15025 | TNIP1 | S79 | ochoa | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. |
| Q15583 | TGIF1 | S149 | ochoa | Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) | Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. |
| Q15672 | TWIST1 | S144 | psp | Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist) | Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:P26687, ECO:0000269|PubMed:12553906, ECO:0000269|PubMed:25981568}. |
| Q2NKX8 | ERCC6L | S1173 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2WGJ9 | FER1L6 | S27 | ochoa | Fer-1-like protein 6 | None |
| Q4G0N8 | SLC9C1 | S214 | ochoa | Solute carrier family 9 member C1 (Na(+)/H(+) exchanger 10) (NHE-10) (Sodium/hydrogen exchanger 10) (Solute carrier family 9 member 10) (Sperm-specific Na(+)/H(+) exchanger) (sNHE) | Sperm-specific solute carrier involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). {ECO:0000250|UniProtKB:Q6UJY2}. |
| Q4KWH8 | PLCH1 | S970 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q4L180 | FILIP1L | S959 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
| Q4L180 | FILIP1L | S962 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
| Q52LW3 | ARHGAP29 | S499 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53H47 | SETMAR | S410 | ochoa | Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)] | Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Also has kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17403897, PubMed:17877369, PubMed:18263876, PubMed:20521842, PubMed:22231448, PubMed:24573677). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). {ECO:0000269|PubMed:16332963, ECO:0000269|PubMed:16672366, ECO:0000269|PubMed:17403897, ECO:0000269|PubMed:17877369, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:20457750, ECO:0000269|PubMed:20521842, ECO:0000269|PubMed:21187428, ECO:0000269|PubMed:22231448, ECO:0000269|PubMed:24573677, ECO:0000303|PubMed:18263876}. |
| Q5PSV4 | BRMS1L | S174 | ochoa | Breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40) (BRMS1-like protein p40) | Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. {ECO:0000269|PubMed:15451426}. |
| Q5QJE6 | DNTTIP2 | S569 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T8I3 | EEIG2 | S191 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5THJ4 | VPS13D | S1065 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5UIP0 | RIF1 | S790 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S2222 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q6DN90 | IQSEC1 | S910 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6L8Q7 | PDE12 | S433 | ochoa | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
| Q6PJT7 | ZC3H14 | S581 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6UWE0 | LRSAM1 | S289 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
| Q6ZS30 | NBEAL1 | S315 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q6ZVD8 | PHLPP2 | S299 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Q70CQ2 | USP34 | S98 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q7L273 | KCTD9 | S318 | ochoa | BTB/POZ domain-containing protein KCTD9 | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. {ECO:0000305}. |
| Q7Z333 | SETX | S980 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z3T8 | ZFYVE16 | S142 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q86SQ0 | PHLDB2 | S31 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86VP1 | TAX1BP1 | S123 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86X27 | RALGPS2 | S293 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86YV5 | PRAG1 | S737 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IVF5 | TIAM2 | S784 | ochoa | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
| Q8N1G1 | REXO1 | S610 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N5A5 | ZGPAT | S56 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N680 | ZBTB2 | S115 | psp | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
| Q8N7R7 | CCNYL1 | S121 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8N9B5 | JMY | S888 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NC24 | RELL2 | S52 | ochoa | RELT-like protein 2 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8TAQ2 | SMARCC2 | S69 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TBE0 | BAHD1 | S679 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TEV9 | SMCR8 | S468 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8TF72 | SHROOM3 | S425 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WTQ7 | GRK7 | S23 | psp | Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7) | Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). {ECO:0000269|PubMed:15946941}. |
| Q8WUY9 | DEPDC1B | S445 | ochoa | DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) | None |
| Q92614 | MYO18A | S234 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92878 | RAD50 | S635 | ochoa|psp | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q96GA3 | LTV1 | S379 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96QD5 | DEPDC7 | S486 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
| Q96R06 | SPAG5 | S411 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RG2 | PASK | S70 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96T17 | MAP7D2 | S650 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q99666 | RGPD5 | S1294 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BU64 | CENPO | S31 | ochoa | Centromere protein O (CENP-O) (Interphase centromere complex protein 36) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:16932742, ECO:0000269|PubMed:18007590}. |
| Q9BUH8 | BEGAIN | S200 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BWT1 | CDCA7 | S142 | ochoa | Cell division cycle-associated protein 7 (Protein JPO1) | Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269|PubMed:11598121, ECO:0000269|PubMed:15994934, ECO:0000269|PubMed:16580749, ECO:0000269|PubMed:23166294}. |
| Q9BYB0 | SHANK3 | S782 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9H2M9 | RAB3GAP2 | S915 | ochoa | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
| Q9H4M9 | EHD1 | S284 | ochoa | EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:31615969}. |
| Q9H845 | ACAD9 | S461 | ochoa | Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) | As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). {ECO:0000269|PubMed:12359260, ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:24158852, ECO:0000269|PubMed:32320651}. |
| Q9H9A7 | RMI1 | S456 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HCY8 | S100A14 | S77 | ochoa | Protein S100-A14 (S100 calcium-binding protein A14) (S114) | Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}. |
| Q9NS87 | KIF15 | S1169 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9NS91 | RAD18 | S125 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NSY0 | NRBP2 | S361 | ochoa | Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16) | May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}. |
| Q9NUQ6 | SPATS2L | S363 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NW97 | TMEM51 | S157 | ochoa | Transmembrane protein 51 | None |
| Q9NYV4 | CDK12 | S440 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZI7 | UBP1 | S390 | ochoa | Upstream-binding protein 1 (Transcription factor LBP-1) | Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:2006421, ECO:0000269|PubMed:8114710}. |
| Q9NZN3 | EHD3 | S284 | ochoa | EH domain-containing protein 3 (PAST homolog 3) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19139087, ECO:0000269|PubMed:21791287, ECO:0000269|PubMed:23781025, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000305|PubMed:20489164}. |
| Q9P219 | CCDC88C | S953 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9UDV7 | ZNF282 | S319 | ochoa | Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) | Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression. |
| Q9UIG0 | BAZ1B | S359 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJM3 | ERRFI1 | S390 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UKA4 | AKAP11 | S1013 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKX2 | MYH2 | S744 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULL0 | KIAA1210 | S818 | ochoa | Acrosomal protein KIAA1210 | None |
| Q9ULV3 | CIZ1 | S821 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9Y2X7 | GIT1 | S54 | psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y3Y2 | CHTOP | S40 | ochoa | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}. |
| Q9Y3Z3 | SAMHD1 | S603 | ochoa | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}. |
| Q9Y5S2 | CDC42BPB | S1527 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y623 | MYH4 | S742 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6D6 | ARFGEF1 | S289 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| P84098 | RPL19 | S37 | Sugiyama | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q07020 | RPL18 | S41 | Sugiyama | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q13283 | G3BP1 | S362 | Sugiyama | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q99613 | EIF3C | S638 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P35579 | MYH9 | S1154 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P40763 | STAT3 | S181 | Sugiyama | Signal transducer and activator of transcription 3 (Acute-phase response factor) | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:38404237}. |
| Q14204 | DYNC1H1 | S3257 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q32P28 | P3H1 | S479 | Sugiyama | Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. {ECO:0000269|PubMed:10951563}. |
| P51957 | NEK4 | S404 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q8TB72 | PUM2 | S943 | Sugiyama | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8TF05 | PPP4R1 | S547 | Sugiyama | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}. |
| P04150 | NR3C1 | S746 | PSP | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| Q5S007 | LRRK2 | S1467 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q8IW41 | MAPKAPK5 | S386 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| P15153 | RAC2 | S158 | Sugiyama | Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2) | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). {ECO:0000269|PubMed:1660188, ECO:0000269|PubMed:30723080}. |
| O60645 | EXOC3 | S89 | Sugiyama | Exocyst complex component 3 (Exocyst complex component Sec6) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q9NS15 | LTBP3 | S871 | Sugiyama | Latent-transforming growth factor beta-binding protein 3 (LTBP-3) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. {ECO:0000303|PubMed:10743502, ECO:0000303|PubMed:11104663}. |
| Q96PH1 | NOX5 | S548 | SIGNOR | NADPH oxidase 5 (EC 1.6.3.-) | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). May play a role in cell growth and apoptosis (PubMed:12686516). {ECO:0000269|PubMed:12686516}.; FUNCTION: [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:11483596, PubMed:14982937, PubMed:17275676, PubMed:17587483, PubMed:21642394, PubMed:22387196, PubMed:22427510, PubMed:24505490, PubMed:36653838). Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin (PubMed:17275676). Regulates redox-dependent processes in lymphocytes and spermatozoa (PubMed:11483596). {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:14982937, ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:17587483, ECO:0000269|PubMed:21642394, ECO:0000269|PubMed:22387196, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:24505490, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:21319793, ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v5]: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner (PubMed:17275676, PubMed:36653838). May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin (PubMed:17275676). However another study showed an absence of oxidase activity (PubMed:22427510). Subject to rapid degradation (PubMed:36653838). {ECO:0000269|PubMed:17275676, ECO:0000269|PubMed:22427510, ECO:0000269|PubMed:36653838}.; FUNCTION: [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}.; FUNCTION: [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity. {ECO:0000269|PubMed:22427510}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.771561e-16 | 15.109 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.038087e-03 | 2.984 |
| R-HSA-212436 | Generic Transcription Pathway | 1.814864e-03 | 2.741 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.414478e-03 | 2.849 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.694662e-03 | 2.328 |
| R-HSA-982772 | Growth hormone receptor signaling | 5.189977e-03 | 2.285 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.965635e-03 | 2.224 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.180257e-03 | 2.498 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.180257e-03 | 2.498 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.711070e-03 | 2.243 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.696387e-03 | 2.432 |
| R-HSA-5620971 | Pyroptosis | 8.011734e-03 | 2.096 |
| R-HSA-9948011 | CASP5 inflammasome assembly | 2.344456e-02 | 1.630 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 4.634229e-02 | 1.334 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 5.759007e-02 | 1.240 |
| R-HSA-8875791 | MET activates STAT3 | 5.759007e-02 | 1.240 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 5.759007e-02 | 1.240 |
| R-HSA-198745 | Signalling to STAT3 | 5.759007e-02 | 1.240 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 6.870587e-02 | 1.163 |
| R-HSA-109703 | PKB-mediated events | 9.054770e-02 | 1.043 |
| R-HSA-165160 | PDE3B signalling | 9.054770e-02 | 1.043 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 1.971694e-02 | 1.705 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.347606e-02 | 1.475 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.604732e-02 | 1.443 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.604732e-02 | 1.443 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.604732e-02 | 1.443 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.604732e-02 | 1.443 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 1.429484e-01 | 0.845 |
| R-HSA-164843 | 2-LTR circle formation | 1.429484e-01 | 0.845 |
| R-HSA-390522 | Striated Muscle Contraction | 1.239151e-02 | 1.907 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 5.295081e-02 | 1.276 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.826975e-01 | 0.738 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.826975e-01 | 0.738 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.548216e-02 | 1.184 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.923448e-01 | 0.716 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.018788e-01 | 0.695 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.018788e-01 | 0.695 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 2.113008e-01 | 0.675 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.644225e-02 | 1.578 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.644225e-02 | 1.578 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.328045e-02 | 1.273 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.328045e-02 | 1.273 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.882475e-02 | 1.230 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.567769e-01 | 0.590 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 6.462948e-02 | 1.190 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.655541e-01 | 0.576 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.276213e-02 | 1.138 |
| R-HSA-380287 | Centrosome maturation | 7.699191e-02 | 1.114 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.094269e-01 | 0.961 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.326123e-01 | 0.877 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.716411e-01 | 0.765 |
| R-HSA-1989781 | PPARA activates gene expression | 1.514238e-01 | 0.820 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.325576e-01 | 0.478 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.368654e-01 | 0.473 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.540104e-01 | 0.451 |
| R-HSA-192823 | Viral mRNA Translation | 3.919819e-01 | 0.407 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.558393e-01 | 0.807 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.144338e-01 | 0.941 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 9.030688e-02 | 1.044 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.971694e-02 | 1.705 |
| R-HSA-448706 | Interleukin-1 processing | 1.327143e-01 | 0.877 |
| R-HSA-156902 | Peptide chain elongation | 3.195891e-01 | 0.495 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.701182e-02 | 1.769 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.630428e-02 | 1.334 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.223586e-01 | 0.912 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 1.826975e-01 | 0.738 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.073106e-02 | 1.217 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.662108e-02 | 1.176 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.079173e-01 | 0.512 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.079173e-01 | 0.512 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.352879e-01 | 0.869 |
| R-HSA-5693538 | Homology Directed Repair | 2.073487e-01 | 0.683 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.892747e-01 | 0.723 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 8.236252e-02 | 1.084 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.817243e-02 | 1.107 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.582732e-01 | 0.446 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 7.969124e-02 | 1.099 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.012768e-01 | 0.994 |
| R-HSA-8849473 | PTK6 Expression | 1.118799e-01 | 0.951 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.630576e-01 | 0.788 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 7.888738e-02 | 1.103 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 7.888738e-02 | 1.103 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.730105e-02 | 1.012 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.716411e-01 | 0.765 |
| R-HSA-3928664 | Ephrin signaling | 2.389082e-01 | 0.622 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.999314e-01 | 0.398 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.160936e-01 | 0.500 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.742282e-01 | 0.562 |
| R-HSA-3000157 | Laminin interactions | 3.079173e-01 | 0.512 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.582732e-01 | 0.446 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.236142e-01 | 0.651 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.417488e-02 | 1.355 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.722093e-01 | 0.764 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.012795e-01 | 0.696 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.795630e-02 | 1.319 |
| R-HSA-68877 | Mitotic Prometaphase | 1.094450e-01 | 0.961 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 8.588396e-02 | 1.066 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.007599e-01 | 0.997 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.012795e-01 | 0.696 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.625258e-01 | 0.441 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 8.945013e-02 | 1.048 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.496098e-02 | 1.456 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 5.759007e-02 | 1.240 |
| R-HSA-844623 | The IPAF inflammasome | 5.759007e-02 | 1.240 |
| R-HSA-390651 | Dopamine receptors | 6.870587e-02 | 1.163 |
| R-HSA-176417 | Phosphorylation of Emi1 | 9.054770e-02 | 1.043 |
| R-HSA-9020933 | Interleukin-23 signaling | 1.223586e-01 | 0.912 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.098059e-02 | 1.509 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.429484e-01 | 0.845 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.630576e-01 | 0.788 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.826975e-01 | 0.738 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.966983e-02 | 1.528 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.113008e-01 | 0.675 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 8.588396e-02 | 1.066 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.400504e-01 | 0.468 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.781373e-01 | 0.422 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.098059e-02 | 1.509 |
| R-HSA-8854691 | Interleukin-20 family signaling | 2.912719e-01 | 0.536 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.742282e-01 | 0.562 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.411650e-01 | 0.467 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.400504e-01 | 0.468 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.389082e-01 | 0.622 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.118799e-01 | 0.951 |
| R-HSA-9020958 | Interleukin-21 signaling | 1.327143e-01 | 0.877 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.004019e-01 | 0.998 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.708156e-02 | 1.244 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.022092e-01 | 0.520 |
| R-HSA-8985947 | Interleukin-9 signaling | 1.223586e-01 | 0.912 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.242397e-01 | 0.906 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.828004e-01 | 0.549 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 7.888738e-02 | 1.103 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.078996e-01 | 0.967 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.078996e-01 | 0.967 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.223586e-01 | 0.912 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.327143e-01 | 0.877 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.996438e-01 | 0.523 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.675892e-02 | 1.435 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.826975e-01 | 0.738 |
| R-HSA-69275 | G2/M Transition | 2.271209e-01 | 0.644 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.729355e-01 | 0.762 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.321515e-01 | 0.634 |
| R-HSA-9008059 | Interleukin-37 signaling | 6.875585e-02 | 1.163 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.923448e-01 | 0.716 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 8.945013e-02 | 1.048 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.155412e-01 | 0.937 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.478490e-01 | 0.459 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.836248e-01 | 0.416 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.888397e-01 | 0.410 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 7.888738e-02 | 1.103 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.555560e-01 | 0.449 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.146445e-02 | 1.089 |
| R-HSA-73894 | DNA Repair | 1.675718e-01 | 0.776 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.764207e-01 | 0.753 |
| R-HSA-2586552 | Signaling by Leptin | 1.429484e-01 | 0.845 |
| R-HSA-844615 | The AIM2 inflammasome | 4.634229e-02 | 1.334 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.012768e-01 | 0.994 |
| R-HSA-9020956 | Interleukin-27 signaling | 1.429484e-01 | 0.845 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 1.729355e-01 | 0.762 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 5.910024e-02 | 1.228 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.486364e-02 | 1.126 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.716633e-01 | 0.765 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.961415e-01 | 0.402 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.961415e-01 | 0.402 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.208745e-01 | 0.918 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.328045e-02 | 1.273 |
| R-HSA-8848021 | Signaling by PTK6 | 5.328045e-02 | 1.273 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.327143e-01 | 0.877 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 1.352053e-01 | 0.869 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 1.352053e-01 | 0.869 |
| R-HSA-162592 | Integration of provirus | 1.630576e-01 | 0.788 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.854881e-01 | 0.414 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.556295e-02 | 1.592 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.999314e-01 | 0.398 |
| R-HSA-199991 | Membrane Trafficking | 1.734050e-01 | 0.761 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.223586e-01 | 0.912 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.826975e-01 | 0.738 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 7.208241e-02 | 1.142 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.018788e-01 | 0.695 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.298143e-01 | 0.639 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.567769e-01 | 0.590 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.160936e-01 | 0.500 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.706991e-01 | 0.431 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.410340e-01 | 0.618 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.410340e-01 | 0.618 |
| R-HSA-5617833 | Cilium Assembly | 2.372097e-01 | 0.625 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.277821e-01 | 0.484 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.198980e-01 | 0.495 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.854881e-01 | 0.414 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.298143e-01 | 0.639 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.279610e-01 | 0.642 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.954740e-01 | 0.403 |
| R-HSA-6783589 | Interleukin-6 family signaling | 2.996438e-01 | 0.523 |
| R-HSA-201451 | Signaling by BMP | 3.241738e-01 | 0.489 |
| R-HSA-397014 | Muscle contraction | 5.961639e-02 | 1.225 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.323059e-02 | 1.878 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.241738e-01 | 0.489 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.555560e-01 | 0.449 |
| R-HSA-2559583 | Cellular Senescence | 2.122070e-01 | 0.673 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.241738e-01 | 0.489 |
| R-HSA-1640170 | Cell Cycle | 3.650544e-01 | 0.438 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.828004e-01 | 0.549 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.109512e-02 | 1.955 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.912719e-01 | 0.536 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.878096e-01 | 0.411 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.885686e-01 | 0.725 |
| R-HSA-9675135 | Diseases of DNA repair | 1.352053e-01 | 0.869 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.585144e-01 | 0.588 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.604732e-02 | 1.443 |
| R-HSA-622312 | Inflammasomes | 6.226303e-02 | 1.206 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 2.018788e-01 | 0.695 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 2.018788e-01 | 0.695 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.160936e-01 | 0.500 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.221032e-01 | 0.913 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.870406e-02 | 1.728 |
| R-HSA-8983711 | OAS antiviral response | 1.729355e-01 | 0.762 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.069564e-01 | 0.971 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.566198e-02 | 1.183 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.776300e-01 | 0.423 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 2.622569e-02 | 1.581 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.826975e-01 | 0.738 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 2.655541e-01 | 0.576 |
| R-HSA-69481 | G2/M Checkpoints | 2.382627e-01 | 0.623 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.397068e-02 | 1.620 |
| R-HSA-1566948 | Elastic fibre formation | 1.004019e-01 | 0.998 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.106172e-01 | 0.677 |
| R-HSA-8984722 | Interleukin-35 Signalling | 1.729355e-01 | 0.762 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.079173e-01 | 0.512 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 1.004019e-01 | 0.998 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.347606e-02 | 1.475 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.530624e-01 | 0.815 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.729355e-01 | 0.762 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 8.588396e-02 | 1.066 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.478490e-01 | 0.459 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.828004e-01 | 0.549 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.478490e-01 | 0.459 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.977019e-01 | 0.704 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.541410e-01 | 0.595 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.140880e-02 | 1.383 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.492344e-01 | 0.826 |
| R-HSA-6806834 | Signaling by MET | 2.803854e-01 | 0.552 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.277821e-01 | 0.484 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 2.912719e-01 | 0.536 |
| R-HSA-5365859 | RA biosynthesis pathway | 3.854881e-01 | 0.414 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.934898e-01 | 0.532 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.102138e-01 | 0.508 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 3.752194e-01 | 0.426 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.742282e-01 | 0.562 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.706991e-01 | 0.431 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.953834e-02 | 1.709 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 5.295081e-02 | 1.276 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.655541e-01 | 0.576 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.045082e-01 | 0.981 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.555560e-01 | 0.449 |
| R-HSA-9833482 | PKR-mediated signaling | 2.803854e-01 | 0.552 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.781373e-01 | 0.422 |
| R-HSA-913531 | Interferon Signaling | 1.098702e-01 | 0.959 |
| R-HSA-525793 | Myogenesis | 3.160936e-01 | 0.500 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.781373e-01 | 0.422 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 3.927525e-01 | 0.406 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.989857e-02 | 1.000 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.497694e-01 | 0.602 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.983841e-01 | 0.400 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.983841e-01 | 0.400 |
| R-HSA-186763 | Downstream signal transduction | 3.555560e-01 | 0.449 |
| R-HSA-68882 | Mitotic Anaphase | 3.075560e-01 | 0.512 |
| R-HSA-2262752 | Cellular responses to stress | 1.124162e-01 | 0.949 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.764207e-01 | 0.753 |
| R-HSA-264876 | Insulin processing | 3.241738e-01 | 0.489 |
| R-HSA-5218859 | Regulated Necrosis | 6.266605e-02 | 1.203 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.912719e-01 | 0.536 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.781373e-01 | 0.422 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.213272e-01 | 0.493 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.478953e-01 | 0.606 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.298143e-01 | 0.639 |
| R-HSA-74160 | Gene expression (Transcription) | 1.829317e-02 | 1.738 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.530624e-01 | 0.815 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.764207e-01 | 0.753 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.625522e-01 | 0.789 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.233159e-01 | 0.909 |
| R-HSA-8853659 | RET signaling | 3.999314e-01 | 0.398 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.379820e-01 | 0.860 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.999314e-01 | 0.398 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.631723e-01 | 0.440 |
| R-HSA-5357801 | Programmed Cell Death | 1.310993e-01 | 0.882 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.131567e-02 | 1.946 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.706991e-01 | 0.431 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.149415e-01 | 0.668 |
| R-HSA-373755 | Semaphorin interactions | 2.063019e-01 | 0.685 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.628889e-01 | 0.580 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.047251e-01 | 0.393 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.070260e-01 | 0.390 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.070260e-01 | 0.390 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.070260e-01 | 0.390 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.126475e-01 | 0.384 |
| R-HSA-9931953 | Biofilm formation | 4.140370e-01 | 0.383 |
| R-HSA-8875878 | MET promotes cell motility | 4.140370e-01 | 0.383 |
| R-HSA-201556 | Signaling by ALK | 4.209656e-01 | 0.376 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.209656e-01 | 0.376 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.209656e-01 | 0.376 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 4.248806e-01 | 0.372 |
| R-HSA-9646399 | Aggrephagy | 4.278127e-01 | 0.369 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.278127e-01 | 0.369 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.328467e-01 | 0.364 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.329629e-01 | 0.364 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.329629e-01 | 0.364 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.409845e-01 | 0.356 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.412662e-01 | 0.355 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.412662e-01 | 0.355 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.412662e-01 | 0.355 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.412662e-01 | 0.355 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.454205e-01 | 0.351 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.459568e-01 | 0.351 |
| R-HSA-165159 | MTOR signalling | 4.478745e-01 | 0.349 |
| R-HSA-983712 | Ion channel transport | 4.485079e-01 | 0.348 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.544050e-01 | 0.343 |
| R-HSA-8854214 | TBC/RABGAPs | 4.544050e-01 | 0.343 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.544050e-01 | 0.343 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.577290e-01 | 0.339 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.607632e-01 | 0.337 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.607632e-01 | 0.337 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.608586e-01 | 0.336 |
| R-HSA-375280 | Amine ligand-binding receptors | 4.608586e-01 | 0.336 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.646703e-01 | 0.333 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.672364e-01 | 0.330 |
| R-HSA-774815 | Nucleosome assembly | 4.672364e-01 | 0.330 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.672364e-01 | 0.330 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.672364e-01 | 0.330 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.672364e-01 | 0.330 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 4.672364e-01 | 0.330 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.685607e-01 | 0.329 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.699223e-01 | 0.328 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.735390e-01 | 0.325 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.735390e-01 | 0.325 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.735390e-01 | 0.325 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.735390e-01 | 0.325 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.735390e-01 | 0.325 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.735390e-01 | 0.325 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.735390e-01 | 0.325 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.735390e-01 | 0.325 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.795856e-01 | 0.319 |
| R-HSA-9658195 | Leishmania infection | 4.795856e-01 | 0.319 |
| R-HSA-70263 | Gluconeogenesis | 4.859227e-01 | 0.313 |
| R-HSA-73893 | DNA Damage Bypass | 4.920055e-01 | 0.308 |
| R-HSA-109704 | PI3K Cascade | 4.980166e-01 | 0.303 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 4.980166e-01 | 0.303 |
| R-HSA-114608 | Platelet degranulation | 5.028047e-01 | 0.299 |
| R-HSA-912446 | Meiotic recombination | 5.039570e-01 | 0.298 |
| R-HSA-2514856 | The phototransduction cascade | 5.039570e-01 | 0.298 |
| R-HSA-72187 | mRNA 3'-end processing | 5.098274e-01 | 0.293 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.098274e-01 | 0.293 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.098274e-01 | 0.293 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.098274e-01 | 0.293 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.098274e-01 | 0.293 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.139016e-01 | 0.289 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.156288e-01 | 0.288 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.156288e-01 | 0.288 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.156288e-01 | 0.288 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.156288e-01 | 0.288 |
| R-HSA-9843745 | Adipogenesis | 5.212089e-01 | 0.283 |
| R-HSA-72649 | Translation initiation complex formation | 5.213618e-01 | 0.283 |
| R-HSA-68886 | M Phase | 5.219086e-01 | 0.282 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.231764e-01 | 0.281 |
| R-HSA-9909396 | Circadian clock | 5.248351e-01 | 0.280 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.270273e-01 | 0.278 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.284429e-01 | 0.277 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.326261e-01 | 0.274 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.326261e-01 | 0.274 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.326261e-01 | 0.274 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.326261e-01 | 0.274 |
| R-HSA-75893 | TNF signaling | 5.326261e-01 | 0.274 |
| R-HSA-418990 | Adherens junctions interactions | 5.374509e-01 | 0.270 |
| R-HSA-112399 | IRS-mediated signalling | 5.381590e-01 | 0.269 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.381590e-01 | 0.269 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.381590e-01 | 0.269 |
| R-HSA-168256 | Immune System | 5.395705e-01 | 0.268 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.436267e-01 | 0.265 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.496993e-01 | 0.260 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.543697e-01 | 0.256 |
| R-HSA-983189 | Kinesins | 5.543697e-01 | 0.256 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.543697e-01 | 0.256 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.543697e-01 | 0.256 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 5.543697e-01 | 0.256 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.566347e-01 | 0.254 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.566347e-01 | 0.254 |
| R-HSA-9664407 | Parasite infection | 5.566347e-01 | 0.254 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.596465e-01 | 0.252 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.596465e-01 | 0.252 |
| R-HSA-450294 | MAP kinase activation | 5.596465e-01 | 0.252 |
| R-HSA-1632852 | Macroautophagy | 5.600741e-01 | 0.252 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.600741e-01 | 0.252 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.648611e-01 | 0.248 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.648611e-01 | 0.248 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.648611e-01 | 0.248 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.648611e-01 | 0.248 |
| R-HSA-9707616 | Heme signaling | 5.648611e-01 | 0.248 |
| R-HSA-186797 | Signaling by PDGF | 5.648611e-01 | 0.248 |
| R-HSA-6799198 | Complex I biogenesis | 5.700143e-01 | 0.244 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.700143e-01 | 0.244 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.700143e-01 | 0.244 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.751067e-01 | 0.240 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.751067e-01 | 0.240 |
| R-HSA-9675108 | Nervous system development | 5.759320e-01 | 0.240 |
| R-HSA-72312 | rRNA processing | 5.760975e-01 | 0.240 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.801392e-01 | 0.236 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.801392e-01 | 0.236 |
| R-HSA-2187338 | Visual phototransduction | 5.836175e-01 | 0.234 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.851124e-01 | 0.233 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.900270e-01 | 0.229 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.948836e-01 | 0.226 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.948836e-01 | 0.226 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.998614e-01 | 0.222 |
| R-HSA-1474244 | Extracellular matrix organization | 6.001589e-01 | 0.222 |
| R-HSA-448424 | Interleukin-17 signaling | 6.044259e-01 | 0.219 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.044259e-01 | 0.219 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.044259e-01 | 0.219 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.058789e-01 | 0.218 |
| R-HSA-73887 | Death Receptor Signaling | 6.062249e-01 | 0.217 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.091129e-01 | 0.215 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.091129e-01 | 0.215 |
| R-HSA-3000178 | ECM proteoglycans | 6.091129e-01 | 0.215 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.091129e-01 | 0.215 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.093780e-01 | 0.215 |
| R-HSA-9612973 | Autophagy | 6.125120e-01 | 0.213 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.137446e-01 | 0.212 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.137446e-01 | 0.212 |
| R-HSA-162582 | Signal Transduction | 6.140267e-01 | 0.212 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.183217e-01 | 0.209 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.183217e-01 | 0.209 |
| R-HSA-9711097 | Cellular response to starvation | 6.187226e-01 | 0.209 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 6.228448e-01 | 0.206 |
| R-HSA-421270 | Cell-cell junction organization | 6.252270e-01 | 0.204 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.273147e-01 | 0.203 |
| R-HSA-8852135 | Protein ubiquitination | 6.273147e-01 | 0.203 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.273147e-01 | 0.203 |
| R-HSA-109581 | Apoptosis | 6.309149e-01 | 0.200 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.368969e-01 | 0.196 |
| R-HSA-6783783 | Interleukin-10 signaling | 6.404104e-01 | 0.194 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.404104e-01 | 0.194 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.404104e-01 | 0.194 |
| R-HSA-4086400 | PCP/CE pathway | 6.404104e-01 | 0.194 |
| R-HSA-168249 | Innate Immune System | 6.418961e-01 | 0.193 |
| R-HSA-9659379 | Sensory processing of sound | 6.446731e-01 | 0.191 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.446731e-01 | 0.191 |
| R-HSA-449147 | Signaling by Interleukins | 6.481776e-01 | 0.188 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.488856e-01 | 0.188 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.530483e-01 | 0.185 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.530483e-01 | 0.185 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.571620e-01 | 0.182 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.571620e-01 | 0.182 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.628818e-01 | 0.179 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.652443e-01 | 0.177 |
| R-HSA-422475 | Axon guidance | 6.654421e-01 | 0.177 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.684504e-01 | 0.175 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.692141e-01 | 0.174 |
| R-HSA-1500620 | Meiosis | 6.692141e-01 | 0.174 |
| R-HSA-6798695 | Neutrophil degranulation | 6.720342e-01 | 0.173 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.731371e-01 | 0.172 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.731371e-01 | 0.172 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.793222e-01 | 0.168 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.808447e-01 | 0.167 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.808447e-01 | 0.167 |
| R-HSA-168255 | Influenza Infection | 6.820486e-01 | 0.166 |
| R-HSA-9663891 | Selective autophagy | 6.846305e-01 | 0.165 |
| R-HSA-446728 | Cell junction organization | 6.881197e-01 | 0.162 |
| R-HSA-112316 | Neuronal System | 6.912604e-01 | 0.160 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.925980e-01 | 0.160 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.991837e-01 | 0.155 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.028994e-01 | 0.153 |
| R-HSA-391251 | Protein folding | 7.028994e-01 | 0.153 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.099087e-01 | 0.149 |
| R-HSA-1474290 | Collagen formation | 7.099087e-01 | 0.149 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 7.133514e-01 | 0.147 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.133514e-01 | 0.147 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.201153e-01 | 0.143 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.205486e-01 | 0.142 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.235041e-01 | 0.141 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.267205e-01 | 0.139 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.267205e-01 | 0.139 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.267205e-01 | 0.139 |
| R-HSA-195721 | Signaling by WNT | 7.294147e-01 | 0.137 |
| R-HSA-3214847 | HATs acetylate histones | 7.299647e-01 | 0.137 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.299647e-01 | 0.137 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.299647e-01 | 0.137 |
| R-HSA-70171 | Glycolysis | 7.331706e-01 | 0.135 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.331706e-01 | 0.135 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.342623e-01 | 0.134 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.363386e-01 | 0.133 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.394692e-01 | 0.131 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.394692e-01 | 0.131 |
| R-HSA-9640148 | Infection with Enterobacteria | 7.410982e-01 | 0.130 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.410982e-01 | 0.130 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.516261e-01 | 0.124 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.545761e-01 | 0.122 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.603719e-01 | 0.119 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.603719e-01 | 0.119 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.603719e-01 | 0.119 |
| R-HSA-1500931 | Cell-Cell communication | 7.628256e-01 | 0.118 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.632185e-01 | 0.117 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.660316e-01 | 0.116 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.660316e-01 | 0.116 |
| R-HSA-6803157 | Antimicrobial peptides | 7.688113e-01 | 0.114 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.715582e-01 | 0.113 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.742727e-01 | 0.111 |
| R-HSA-8957322 | Metabolism of steroids | 7.765724e-01 | 0.110 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.822250e-01 | 0.107 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.822250e-01 | 0.107 |
| R-HSA-70326 | Glucose metabolism | 7.898985e-01 | 0.102 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.898985e-01 | 0.102 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.905625e-01 | 0.102 |
| R-HSA-162906 | HIV Infection | 7.924314e-01 | 0.101 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.948642e-01 | 0.100 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.948642e-01 | 0.100 |
| R-HSA-68875 | Mitotic Prophase | 7.973030e-01 | 0.098 |
| R-HSA-73886 | Chromosome Maintenance | 7.997131e-01 | 0.097 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.997131e-01 | 0.097 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.020946e-01 | 0.096 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.020946e-01 | 0.096 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.044479e-01 | 0.095 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.051083e-01 | 0.094 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.051298e-01 | 0.094 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.067734e-01 | 0.093 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.125005e-01 | 0.090 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.179947e-01 | 0.087 |
| R-HSA-8956319 | Nucleotide catabolism | 8.201599e-01 | 0.086 |
| R-HSA-1474165 | Reproduction | 8.244138e-01 | 0.084 |
| R-HSA-4839726 | Chromatin organization | 8.299888e-01 | 0.081 |
| R-HSA-9609646 | HCMV Infection | 8.315419e-01 | 0.080 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.385293e-01 | 0.076 |
| R-HSA-5688426 | Deubiquitination | 8.391178e-01 | 0.076 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.405957e-01 | 0.075 |
| R-HSA-109582 | Hemostasis | 8.454829e-01 | 0.073 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.515154e-01 | 0.070 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.600500e-01 | 0.065 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.618159e-01 | 0.065 |
| R-HSA-166520 | Signaling by NTRKs | 8.618159e-01 | 0.065 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.650890e-01 | 0.063 |
| R-HSA-2142753 | Arachidonate metabolism | 8.682848e-01 | 0.061 |
| R-HSA-9609507 | Protein localization | 8.698544e-01 | 0.061 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.713702e-01 | 0.060 |
| R-HSA-5663205 | Infectious disease | 8.727083e-01 | 0.059 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.749573e-01 | 0.058 |
| R-HSA-9610379 | HCMV Late Events | 8.759489e-01 | 0.058 |
| R-HSA-162587 | HIV Life Cycle | 8.759489e-01 | 0.058 |
| R-HSA-418555 | G alpha (s) signalling events | 8.963793e-01 | 0.048 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.988373e-01 | 0.046 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.988373e-01 | 0.046 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.988373e-01 | 0.046 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.012373e-01 | 0.045 |
| R-HSA-72766 | Translation | 9.042532e-01 | 0.044 |
| R-HSA-611105 | Respiratory electron transport | 9.047315e-01 | 0.043 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.134597e-01 | 0.039 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.155831e-01 | 0.038 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.185059e-01 | 0.037 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.213920e-01 | 0.036 |
| R-HSA-9609690 | HCMV Early Events | 9.232593e-01 | 0.035 |
| R-HSA-428157 | Sphingolipid metabolism | 9.277368e-01 | 0.033 |
| R-HSA-72172 | mRNA Splicing | 9.311310e-01 | 0.031 |
| R-HSA-9824446 | Viral Infection Pathways | 9.324923e-01 | 0.030 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.374507e-01 | 0.028 |
| R-HSA-1266738 | Developmental Biology | 9.400176e-01 | 0.027 |
| R-HSA-1280218 | Adaptive Immune System | 9.416723e-01 | 0.026 |
| R-HSA-597592 | Post-translational protein modification | 9.420052e-01 | 0.026 |
| R-HSA-8951664 | Neddylation | 9.438732e-01 | 0.025 |
| R-HSA-1643685 | Disease | 9.472056e-01 | 0.024 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.484112e-01 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 9.531520e-01 | 0.021 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.586808e-01 | 0.018 |
| R-HSA-8978868 | Fatty acid metabolism | 9.637842e-01 | 0.016 |
| R-HSA-416476 | G alpha (q) signalling events | 9.665808e-01 | 0.015 |
| R-HSA-9679506 | SARS-CoV Infections | 9.685388e-01 | 0.014 |
| R-HSA-392499 | Metabolism of proteins | 9.748302e-01 | 0.011 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.752941e-01 | 0.011 |
| R-HSA-8953854 | Metabolism of RNA | 9.762970e-01 | 0.010 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.772999e-01 | 0.010 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.816950e-01 | 0.008 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.836304e-01 | 0.007 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.868403e-01 | 0.006 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.880579e-01 | 0.005 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.899252e-01 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.900468e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.931149e-01 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 9.934834e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.941730e-01 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 9.946650e-01 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.961069e-01 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 9.962212e-01 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.967563e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.992596e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999736e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.886 | 0.123 | 2 | 0.851 |
CLK3 |
0.882 | 0.249 | 1 | 0.868 |
CDC7 |
0.880 | 0.035 | 1 | 0.828 |
MOS |
0.877 | 0.070 | 1 | 0.852 |
CAMK1B |
0.876 | 0.097 | -3 | 0.877 |
DSTYK |
0.875 | 0.052 | 2 | 0.872 |
ATR |
0.875 | 0.123 | 1 | 0.871 |
PRPK |
0.875 | -0.152 | -1 | 0.889 |
RAF1 |
0.875 | 0.003 | 1 | 0.830 |
NLK |
0.873 | 0.063 | 1 | 0.839 |
PIM3 |
0.872 | 0.058 | -3 | 0.825 |
RSK2 |
0.872 | 0.150 | -3 | 0.773 |
PRKD2 |
0.871 | 0.152 | -3 | 0.760 |
CAMLCK |
0.870 | 0.173 | -2 | 0.901 |
CDKL1 |
0.870 | 0.045 | -3 | 0.810 |
MTOR |
0.870 | -0.116 | 1 | 0.787 |
BMPR2 |
0.870 | -0.140 | -2 | 0.854 |
PDHK4 |
0.870 | -0.255 | 1 | 0.848 |
GCN2 |
0.869 | -0.168 | 2 | 0.791 |
NEK6 |
0.869 | 0.017 | -2 | 0.818 |
PRKD1 |
0.869 | 0.089 | -3 | 0.823 |
CHAK2 |
0.868 | 0.072 | -1 | 0.886 |
AURC |
0.868 | 0.281 | -2 | 0.799 |
ULK2 |
0.868 | -0.127 | 2 | 0.791 |
HIPK4 |
0.868 | 0.104 | 1 | 0.830 |
WNK1 |
0.868 | 0.043 | -2 | 0.869 |
TGFBR2 |
0.868 | -0.002 | -2 | 0.788 |
PKCD |
0.867 | 0.177 | 2 | 0.815 |
IKKB |
0.867 | -0.132 | -2 | 0.733 |
MST4 |
0.867 | 0.108 | 2 | 0.889 |
PDHK1 |
0.867 | -0.158 | 1 | 0.834 |
NIK |
0.867 | 0.041 | -3 | 0.894 |
CAMK2G |
0.867 | -0.092 | 2 | 0.774 |
SKMLCK |
0.866 | 0.137 | -2 | 0.891 |
ERK5 |
0.866 | -0.001 | 1 | 0.764 |
P70S6KB |
0.866 | 0.122 | -3 | 0.801 |
DAPK2 |
0.866 | 0.122 | -3 | 0.887 |
NDR2 |
0.866 | 0.009 | -3 | 0.830 |
TBK1 |
0.866 | -0.134 | 1 | 0.726 |
PKN2 |
0.865 | 0.092 | -3 | 0.836 |
KIS |
0.865 | 0.110 | 1 | 0.707 |
NEK7 |
0.865 | -0.085 | -3 | 0.888 |
PKN3 |
0.865 | 0.020 | -3 | 0.831 |
MLK1 |
0.864 | -0.033 | 2 | 0.837 |
NUAK2 |
0.864 | 0.017 | -3 | 0.836 |
PKACG |
0.864 | 0.173 | -2 | 0.841 |
GRK5 |
0.864 | -0.105 | -3 | 0.876 |
RIPK3 |
0.863 | -0.046 | 3 | 0.713 |
RSK3 |
0.863 | 0.087 | -3 | 0.763 |
IKKE |
0.862 | -0.142 | 1 | 0.724 |
SRPK1 |
0.862 | 0.081 | -3 | 0.745 |
PIM1 |
0.862 | 0.098 | -3 | 0.769 |
NDR1 |
0.862 | 0.028 | -3 | 0.830 |
CDKL5 |
0.862 | 0.027 | -3 | 0.800 |
P90RSK |
0.861 | 0.052 | -3 | 0.776 |
GRK6 |
0.861 | -0.001 | 1 | 0.845 |
ICK |
0.861 | 0.061 | -3 | 0.847 |
AURB |
0.861 | 0.251 | -2 | 0.791 |
TSSK2 |
0.860 | 0.066 | -5 | 0.835 |
AMPKA1 |
0.860 | 0.020 | -3 | 0.848 |
HUNK |
0.860 | -0.112 | 2 | 0.788 |
MAPKAPK3 |
0.859 | -0.003 | -3 | 0.771 |
TSSK1 |
0.859 | 0.082 | -3 | 0.865 |
ATM |
0.859 | 0.090 | 1 | 0.824 |
BMPR1B |
0.859 | 0.139 | 1 | 0.781 |
GRK1 |
0.859 | 0.019 | -2 | 0.777 |
ULK1 |
0.858 | -0.168 | -3 | 0.860 |
PKG2 |
0.858 | 0.233 | -2 | 0.810 |
PAK1 |
0.858 | 0.151 | -2 | 0.860 |
WNK3 |
0.858 | -0.174 | 1 | 0.813 |
PAK6 |
0.858 | 0.211 | -2 | 0.813 |
BCKDK |
0.858 | -0.141 | -1 | 0.876 |
MARK4 |
0.858 | -0.050 | 4 | 0.868 |
CLK4 |
0.858 | 0.179 | -3 | 0.766 |
PRKD3 |
0.857 | 0.088 | -3 | 0.744 |
PKACB |
0.857 | 0.243 | -2 | 0.804 |
CDK8 |
0.857 | 0.047 | 1 | 0.684 |
NEK9 |
0.856 | -0.116 | 2 | 0.848 |
SRPK2 |
0.856 | 0.074 | -3 | 0.671 |
PAK3 |
0.856 | 0.113 | -2 | 0.852 |
IKKA |
0.856 | -0.046 | -2 | 0.705 |
RIPK1 |
0.856 | -0.109 | 1 | 0.826 |
ANKRD3 |
0.856 | -0.070 | 1 | 0.845 |
PKR |
0.856 | 0.092 | 1 | 0.862 |
MLK3 |
0.856 | 0.047 | 2 | 0.781 |
ALK4 |
0.855 | 0.015 | -2 | 0.810 |
PKCA |
0.855 | 0.131 | 2 | 0.773 |
MNK2 |
0.855 | 0.148 | -2 | 0.861 |
IRE1 |
0.855 | -0.024 | 1 | 0.819 |
MYLK4 |
0.855 | 0.158 | -2 | 0.861 |
CAMK4 |
0.855 | 0.014 | -3 | 0.827 |
CLK1 |
0.855 | 0.156 | -3 | 0.744 |
PKCB |
0.854 | 0.117 | 2 | 0.775 |
MAPKAPK2 |
0.854 | 0.028 | -3 | 0.715 |
PKCG |
0.854 | 0.095 | 2 | 0.775 |
RSK4 |
0.853 | 0.135 | -3 | 0.731 |
TGFBR1 |
0.853 | 0.040 | -2 | 0.777 |
PRKX |
0.853 | 0.249 | -3 | 0.650 |
IRE2 |
0.853 | 0.020 | 2 | 0.790 |
DLK |
0.853 | -0.175 | 1 | 0.830 |
GRK4 |
0.853 | -0.118 | -2 | 0.797 |
MSK2 |
0.852 | 0.067 | -3 | 0.743 |
AMPKA2 |
0.852 | 0.004 | -3 | 0.811 |
NEK2 |
0.852 | 0.003 | 2 | 0.833 |
DYRK2 |
0.852 | 0.077 | 1 | 0.731 |
MLK2 |
0.852 | -0.117 | 2 | 0.832 |
LATS2 |
0.852 | -0.058 | -5 | 0.732 |
FAM20C |
0.851 | 0.050 | 2 | 0.571 |
AURA |
0.851 | 0.221 | -2 | 0.766 |
CAMK2D |
0.851 | -0.112 | -3 | 0.861 |
PLK1 |
0.851 | -0.048 | -2 | 0.786 |
CDK19 |
0.851 | 0.046 | 1 | 0.645 |
CDK7 |
0.850 | 0.042 | 1 | 0.688 |
PKCH |
0.850 | 0.080 | 2 | 0.762 |
MELK |
0.850 | 0.000 | -3 | 0.805 |
ACVR2A |
0.850 | 0.036 | -2 | 0.772 |
PAK2 |
0.850 | 0.108 | -2 | 0.847 |
LATS1 |
0.850 | 0.061 | -3 | 0.856 |
TTBK2 |
0.849 | -0.205 | 2 | 0.698 |
NIM1 |
0.849 | -0.109 | 3 | 0.770 |
AKT2 |
0.849 | 0.136 | -3 | 0.683 |
CDK1 |
0.849 | 0.093 | 1 | 0.666 |
DNAPK |
0.849 | 0.092 | 1 | 0.762 |
MSK1 |
0.849 | 0.134 | -3 | 0.739 |
SRPK3 |
0.848 | 0.017 | -3 | 0.724 |
CDK5 |
0.848 | 0.089 | 1 | 0.708 |
SMG1 |
0.848 | 0.009 | 1 | 0.832 |
ACVR2B |
0.848 | 0.033 | -2 | 0.778 |
PKCZ |
0.848 | 0.060 | 2 | 0.803 |
NUAK1 |
0.848 | -0.031 | -3 | 0.790 |
CHAK1 |
0.848 | -0.057 | 2 | 0.801 |
ALK2 |
0.848 | 0.033 | -2 | 0.787 |
GRK7 |
0.847 | 0.059 | 1 | 0.774 |
QIK |
0.847 | -0.083 | -3 | 0.858 |
JNK2 |
0.847 | 0.101 | 1 | 0.635 |
SGK3 |
0.847 | 0.117 | -3 | 0.747 |
MLK4 |
0.847 | -0.027 | 2 | 0.745 |
CLK2 |
0.847 | 0.187 | -3 | 0.734 |
HIPK1 |
0.847 | 0.121 | 1 | 0.743 |
VRK2 |
0.847 | -0.186 | 1 | 0.872 |
JNK3 |
0.846 | 0.075 | 1 | 0.673 |
MASTL |
0.846 | -0.414 | -2 | 0.775 |
SIK |
0.846 | -0.007 | -3 | 0.767 |
CAMK2B |
0.846 | -0.027 | 2 | 0.725 |
MNK1 |
0.845 | 0.104 | -2 | 0.872 |
TLK2 |
0.845 | -0.032 | 1 | 0.835 |
MEK1 |
0.845 | -0.207 | 2 | 0.818 |
PIM2 |
0.845 | 0.079 | -3 | 0.746 |
QSK |
0.845 | -0.016 | 4 | 0.844 |
HIPK2 |
0.845 | 0.124 | 1 | 0.642 |
CDK13 |
0.844 | 0.025 | 1 | 0.665 |
CDK2 |
0.844 | 0.042 | 1 | 0.747 |
CDK18 |
0.844 | 0.077 | 1 | 0.623 |
P38A |
0.844 | 0.056 | 1 | 0.698 |
SMMLCK |
0.844 | 0.122 | -3 | 0.832 |
PKACA |
0.844 | 0.210 | -2 | 0.770 |
YSK4 |
0.844 | -0.125 | 1 | 0.757 |
BMPR1A |
0.843 | 0.100 | 1 | 0.760 |
CAMK1G |
0.843 | 0.024 | -3 | 0.776 |
PINK1 |
0.843 | -0.061 | 1 | 0.851 |
PHKG1 |
0.843 | -0.074 | -3 | 0.828 |
PERK |
0.843 | -0.092 | -2 | 0.810 |
BRAF |
0.843 | -0.016 | -4 | 0.836 |
CAMK2A |
0.843 | -0.026 | 2 | 0.745 |
HRI |
0.842 | -0.116 | -2 | 0.823 |
ERK2 |
0.842 | 0.041 | 1 | 0.685 |
P38B |
0.842 | 0.075 | 1 | 0.638 |
HIPK3 |
0.841 | 0.088 | 1 | 0.719 |
DYRK1A |
0.841 | 0.064 | 1 | 0.755 |
CDK17 |
0.840 | 0.066 | 1 | 0.582 |
AKT1 |
0.840 | 0.155 | -3 | 0.697 |
ERK1 |
0.840 | 0.054 | 1 | 0.622 |
TLK1 |
0.840 | -0.043 | -2 | 0.791 |
GRK2 |
0.839 | -0.062 | -2 | 0.704 |
PKCT |
0.839 | 0.080 | 2 | 0.769 |
DRAK1 |
0.838 | -0.061 | 1 | 0.771 |
PRP4 |
0.838 | 0.018 | -3 | 0.756 |
P38G |
0.838 | 0.068 | 1 | 0.569 |
PLK3 |
0.838 | -0.117 | 2 | 0.726 |
MARK3 |
0.838 | -0.039 | 4 | 0.798 |
IRAK4 |
0.838 | -0.040 | 1 | 0.810 |
SNRK |
0.838 | -0.166 | 2 | 0.693 |
MARK2 |
0.837 | -0.059 | 4 | 0.764 |
CHK1 |
0.837 | -0.069 | -3 | 0.812 |
CDK12 |
0.837 | 0.028 | 1 | 0.641 |
MST3 |
0.837 | 0.035 | 2 | 0.867 |
CDK14 |
0.837 | 0.083 | 1 | 0.671 |
DYRK3 |
0.837 | 0.129 | 1 | 0.750 |
DYRK1B |
0.837 | 0.084 | 1 | 0.686 |
WNK4 |
0.836 | -0.108 | -2 | 0.841 |
BRSK1 |
0.836 | -0.082 | -3 | 0.789 |
NEK5 |
0.836 | -0.072 | 1 | 0.826 |
PKCI |
0.836 | 0.084 | 2 | 0.781 |
CDK9 |
0.836 | 0.002 | 1 | 0.667 |
MEKK1 |
0.835 | -0.139 | 1 | 0.808 |
MEK5 |
0.835 | -0.250 | 2 | 0.823 |
SSTK |
0.835 | 0.017 | 4 | 0.843 |
P70S6K |
0.835 | 0.022 | -3 | 0.713 |
CDK3 |
0.835 | 0.094 | 1 | 0.596 |
MARK1 |
0.835 | -0.073 | 4 | 0.828 |
CDK10 |
0.835 | 0.111 | 1 | 0.658 |
P38D |
0.834 | 0.096 | 1 | 0.581 |
PAK5 |
0.834 | 0.144 | -2 | 0.740 |
MAPKAPK5 |
0.834 | -0.148 | -3 | 0.734 |
BRSK2 |
0.834 | -0.138 | -3 | 0.825 |
BUB1 |
0.833 | 0.225 | -5 | 0.788 |
PKCE |
0.833 | 0.131 | 2 | 0.771 |
ZAK |
0.833 | -0.160 | 1 | 0.778 |
MEKK2 |
0.833 | -0.129 | 2 | 0.809 |
NEK8 |
0.833 | -0.059 | 2 | 0.840 |
MEKK3 |
0.832 | -0.208 | 1 | 0.791 |
DYRK4 |
0.832 | 0.072 | 1 | 0.651 |
MPSK1 |
0.832 | -0.016 | 1 | 0.765 |
DAPK3 |
0.832 | 0.143 | -3 | 0.798 |
CAMKK1 |
0.831 | -0.103 | -2 | 0.735 |
PHKG2 |
0.831 | -0.032 | -3 | 0.803 |
TAO3 |
0.831 | -0.048 | 1 | 0.788 |
CAMK1D |
0.830 | 0.040 | -3 | 0.684 |
CDK16 |
0.830 | 0.083 | 1 | 0.598 |
DCAMKL1 |
0.830 | -0.061 | -3 | 0.771 |
PAK4 |
0.830 | 0.147 | -2 | 0.752 |
LKB1 |
0.829 | -0.021 | -3 | 0.873 |
PLK4 |
0.829 | -0.194 | 2 | 0.631 |
CK1E |
0.829 | -0.048 | -3 | 0.557 |
DCAMKL2 |
0.829 | -0.071 | -3 | 0.808 |
PASK |
0.828 | -0.038 | -3 | 0.850 |
GAK |
0.828 | -0.024 | 1 | 0.800 |
MRCKB |
0.828 | 0.165 | -3 | 0.734 |
MRCKA |
0.827 | 0.161 | -3 | 0.755 |
CAMKK2 |
0.827 | -0.095 | -2 | 0.738 |
TTBK1 |
0.827 | -0.205 | 2 | 0.618 |
TAO2 |
0.826 | -0.079 | 2 | 0.867 |
NEK4 |
0.826 | -0.066 | 1 | 0.792 |
TAK1 |
0.825 | -0.003 | 1 | 0.818 |
NEK11 |
0.825 | -0.193 | 1 | 0.796 |
AKT3 |
0.825 | 0.134 | -3 | 0.609 |
ERK7 |
0.825 | 0.022 | 2 | 0.567 |
ROCK2 |
0.825 | 0.174 | -3 | 0.774 |
DAPK1 |
0.825 | 0.119 | -3 | 0.781 |
SGK1 |
0.825 | 0.118 | -3 | 0.592 |
EEF2K |
0.825 | -0.015 | 3 | 0.816 |
GCK |
0.825 | -0.004 | 1 | 0.800 |
GSK3B |
0.824 | -0.038 | 4 | 0.431 |
MST2 |
0.824 | -0.023 | 1 | 0.798 |
CHK2 |
0.823 | 0.023 | -3 | 0.627 |
TNIK |
0.823 | 0.032 | 3 | 0.836 |
PKN1 |
0.823 | 0.013 | -3 | 0.733 |
IRAK1 |
0.823 | -0.271 | -1 | 0.825 |
LOK |
0.822 | 0.016 | -2 | 0.780 |
HGK |
0.822 | -0.032 | 3 | 0.843 |
LRRK2 |
0.822 | -0.098 | 2 | 0.854 |
CK1D |
0.822 | -0.040 | -3 | 0.510 |
GSK3A |
0.822 | -0.001 | 4 | 0.441 |
CAMK1A |
0.821 | 0.058 | -3 | 0.641 |
CK2A2 |
0.821 | 0.052 | 1 | 0.688 |
PDK1 |
0.821 | -0.149 | 1 | 0.785 |
VRK1 |
0.821 | -0.089 | 2 | 0.848 |
GRK3 |
0.820 | -0.078 | -2 | 0.661 |
CK1A2 |
0.820 | -0.034 | -3 | 0.506 |
JNK1 |
0.820 | 0.025 | 1 | 0.633 |
CDK6 |
0.820 | 0.044 | 1 | 0.638 |
MINK |
0.820 | -0.057 | 1 | 0.785 |
HPK1 |
0.820 | -0.014 | 1 | 0.788 |
NEK1 |
0.820 | -0.051 | 1 | 0.795 |
MST1 |
0.819 | -0.013 | 1 | 0.787 |
DMPK1 |
0.819 | 0.194 | -3 | 0.752 |
CDK4 |
0.818 | 0.043 | 1 | 0.634 |
SLK |
0.818 | -0.033 | -2 | 0.713 |
MAK |
0.818 | 0.095 | -2 | 0.769 |
PKG1 |
0.818 | 0.147 | -2 | 0.745 |
MOK |
0.818 | 0.076 | 1 | 0.744 |
MEKK6 |
0.817 | -0.161 | 1 | 0.772 |
MAP3K15 |
0.816 | -0.164 | 1 | 0.750 |
CK1G1 |
0.815 | -0.102 | -3 | 0.556 |
KHS2 |
0.815 | 0.043 | 1 | 0.798 |
KHS1 |
0.815 | 0.006 | 1 | 0.780 |
ROCK1 |
0.814 | 0.163 | -3 | 0.745 |
PLK2 |
0.813 | -0.073 | -3 | 0.795 |
STK33 |
0.812 | -0.162 | 2 | 0.603 |
YSK1 |
0.812 | -0.070 | 2 | 0.838 |
HASPIN |
0.811 | 0.068 | -1 | 0.717 |
PDHK3_TYR |
0.811 | 0.211 | 4 | 0.938 |
RIPK2 |
0.810 | -0.258 | 1 | 0.724 |
SBK |
0.810 | 0.019 | -3 | 0.561 |
TTK |
0.809 | 0.023 | -2 | 0.799 |
CK2A1 |
0.809 | 0.021 | 1 | 0.669 |
CRIK |
0.809 | 0.089 | -3 | 0.692 |
MEK2 |
0.808 | -0.287 | 2 | 0.805 |
PBK |
0.807 | -0.075 | 1 | 0.696 |
MYO3B |
0.807 | 0.049 | 2 | 0.858 |
NEK3 |
0.804 | -0.166 | 1 | 0.735 |
TESK1_TYR |
0.803 | 0.026 | 3 | 0.876 |
MYO3A |
0.803 | 0.003 | 1 | 0.817 |
ALPHAK3 |
0.802 | -0.026 | -1 | 0.823 |
OSR1 |
0.802 | -0.079 | 2 | 0.798 |
PDHK4_TYR |
0.800 | 0.041 | 2 | 0.856 |
LIMK2_TYR |
0.800 | 0.097 | -3 | 0.908 |
MAP2K4_TYR |
0.798 | -0.100 | -1 | 0.908 |
BMPR2_TYR |
0.797 | 0.009 | -1 | 0.902 |
MAP2K6_TYR |
0.797 | -0.064 | -1 | 0.908 |
PKMYT1_TYR |
0.796 | -0.105 | 3 | 0.834 |
BIKE |
0.796 | -0.062 | 1 | 0.660 |
MAP2K7_TYR |
0.796 | -0.222 | 2 | 0.851 |
PINK1_TYR |
0.795 | -0.132 | 1 | 0.830 |
PDHK1_TYR |
0.795 | -0.070 | -1 | 0.921 |
TAO1 |
0.794 | -0.118 | 1 | 0.716 |
ASK1 |
0.793 | -0.224 | 1 | 0.741 |
EPHA6 |
0.793 | 0.036 | -1 | 0.922 |
RET |
0.792 | -0.060 | 1 | 0.796 |
LIMK1_TYR |
0.791 | -0.116 | 2 | 0.861 |
EPHB4 |
0.789 | -0.006 | -1 | 0.909 |
YANK3 |
0.789 | -0.109 | 2 | 0.377 |
TYK2 |
0.788 | -0.129 | 1 | 0.789 |
MST1R |
0.788 | -0.110 | 3 | 0.776 |
JAK2 |
0.785 | -0.125 | 1 | 0.779 |
ROS1 |
0.785 | -0.121 | 3 | 0.747 |
TYRO3 |
0.785 | -0.155 | 3 | 0.779 |
DDR1 |
0.783 | -0.143 | 4 | 0.867 |
CSF1R |
0.783 | -0.127 | 3 | 0.760 |
TXK |
0.783 | 0.046 | 1 | 0.789 |
ABL2 |
0.782 | -0.045 | -1 | 0.867 |
STLK3 |
0.781 | -0.249 | 1 | 0.744 |
FER |
0.780 | -0.146 | 1 | 0.831 |
JAK3 |
0.780 | -0.105 | 1 | 0.768 |
EPHB1 |
0.780 | -0.052 | 1 | 0.813 |
EPHA4 |
0.778 | -0.072 | 2 | 0.729 |
INSRR |
0.778 | -0.093 | 3 | 0.731 |
YES1 |
0.778 | -0.107 | -1 | 0.886 |
TNNI3K_TYR |
0.778 | -0.010 | 1 | 0.804 |
CK1A |
0.777 | -0.097 | -3 | 0.415 |
PDGFRB |
0.777 | -0.147 | 3 | 0.779 |
EPHB2 |
0.777 | -0.038 | -1 | 0.896 |
WEE1_TYR |
0.777 | -0.052 | -1 | 0.807 |
ABL1 |
0.777 | -0.084 | -1 | 0.865 |
AAK1 |
0.777 | -0.030 | 1 | 0.547 |
EPHB3 |
0.777 | -0.073 | -1 | 0.897 |
FGR |
0.777 | -0.173 | 1 | 0.802 |
ITK |
0.776 | -0.094 | -1 | 0.861 |
FLT3 |
0.776 | -0.143 | 3 | 0.764 |
TNK1 |
0.776 | -0.087 | 3 | 0.754 |
KDR |
0.776 | -0.091 | 3 | 0.722 |
KIT |
0.775 | -0.148 | 3 | 0.764 |
FGFR2 |
0.775 | -0.157 | 3 | 0.771 |
TNK2 |
0.775 | -0.135 | 3 | 0.713 |
SRMS |
0.775 | -0.138 | 1 | 0.820 |
JAK1 |
0.774 | -0.085 | 1 | 0.727 |
NEK10_TYR |
0.773 | -0.140 | 1 | 0.654 |
TEC |
0.773 | -0.066 | -1 | 0.811 |
HCK |
0.773 | -0.166 | -1 | 0.872 |
TEK |
0.772 | -0.199 | 3 | 0.707 |
AXL |
0.772 | -0.162 | 3 | 0.744 |
LCK |
0.772 | -0.088 | -1 | 0.872 |
ALK |
0.771 | -0.120 | 3 | 0.701 |
FGFR1 |
0.771 | -0.174 | 3 | 0.741 |
PDGFRA |
0.770 | -0.222 | 3 | 0.767 |
MERTK |
0.770 | -0.148 | 3 | 0.738 |
BMX |
0.769 | -0.086 | -1 | 0.767 |
BTK |
0.769 | -0.221 | -1 | 0.828 |
BLK |
0.768 | -0.072 | -1 | 0.873 |
MET |
0.768 | -0.147 | 3 | 0.752 |
LTK |
0.767 | -0.148 | 3 | 0.717 |
EPHA7 |
0.767 | -0.101 | 2 | 0.735 |
PTK6 |
0.767 | -0.211 | -1 | 0.802 |
FLT1 |
0.766 | -0.114 | -1 | 0.897 |
EPHA3 |
0.765 | -0.154 | 2 | 0.711 |
ERBB2 |
0.764 | -0.198 | 1 | 0.761 |
NTRK1 |
0.763 | -0.232 | -1 | 0.885 |
DDR2 |
0.763 | -0.046 | 3 | 0.716 |
FLT4 |
0.763 | -0.182 | 3 | 0.714 |
FRK |
0.763 | -0.141 | -1 | 0.878 |
EPHA1 |
0.763 | -0.173 | 3 | 0.721 |
FGFR3 |
0.762 | -0.188 | 3 | 0.744 |
FYN |
0.762 | -0.082 | -1 | 0.842 |
NTRK2 |
0.761 | -0.232 | 3 | 0.717 |
EPHA5 |
0.761 | -0.091 | 2 | 0.711 |
CK1G3 |
0.761 | -0.095 | -3 | 0.364 |
INSR |
0.760 | -0.185 | 3 | 0.701 |
PTK2B |
0.759 | -0.103 | -1 | 0.849 |
MATK |
0.758 | -0.161 | -1 | 0.795 |
LYN |
0.758 | -0.175 | 3 | 0.673 |
EPHA8 |
0.757 | -0.122 | -1 | 0.866 |
EGFR |
0.755 | -0.112 | 1 | 0.674 |
PTK2 |
0.755 | -0.012 | -1 | 0.845 |
NTRK3 |
0.754 | -0.208 | -1 | 0.827 |
CSK |
0.753 | -0.215 | 2 | 0.742 |
SRC |
0.752 | -0.158 | -1 | 0.850 |
SYK |
0.751 | -0.040 | -1 | 0.817 |
YANK2 |
0.750 | -0.162 | 2 | 0.387 |
FGFR4 |
0.749 | -0.166 | -1 | 0.839 |
MUSK |
0.748 | -0.171 | 1 | 0.658 |
EPHA2 |
0.747 | -0.121 | -1 | 0.841 |
IGF1R |
0.745 | -0.180 | 3 | 0.642 |
ERBB4 |
0.742 | -0.111 | 1 | 0.708 |
FES |
0.735 | -0.183 | -1 | 0.764 |
CK1G2 |
0.734 | -0.134 | -3 | 0.466 |
ZAP70 |
0.728 | -0.081 | -1 | 0.733 |