Motif 766 (n=120)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQJ8 | ATRIP | S34 | ochoa | ATR interacting protein | None |
| O00221 | NFKBIE | S161 | psp | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}. |
| O14646 | CHD1 | S1511 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O15013 | ARHGEF10 | S1229 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| O15061 | SYNM | S584 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43707 | ACTN4 | S608 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60264 | SMARCA5 | S755 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60271 | SPAG9 | S358 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O94823 | ATP10B | S984 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
| O94916 | NFAT5 | S229 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| P00519 | ABL1 | T394 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P01023 | A2M | S928 | ochoa | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| P02675 | FGB | S67 | ochoa | Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P05114 | HMGN1 | S21 | ochoa|psp | Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}. |
| P06239 | LCK | T395 | ochoa|psp | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P06241 | FYN | T421 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P06746 | POLB | S55 | psp | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed:10556592, PubMed:17526740, PubMed:9556598, PubMed:9572863, PubMed:9614142). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed:9614142). {ECO:0000269|PubMed:10556592, ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:17526740, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9556598, ECO:0000269|PubMed:9572863, ECO:0000269|PubMed:9614142}. |
| P07947 | YES1 | T427 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P07948 | LYN | T398 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08581 | MET | Y1235 | ochoa|psp | Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}. |
| P08631 | HCK | T412 | ochoa | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P09874 | PARP1 | S362 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P10412 | H1-4 | S113 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P11388 | TOP2A | S1449 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12931 | SRC | T420 | ochoa | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P13667 | PDIA4 | S250 | ochoa | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P16284 | PECAM1 | S647 | ochoa | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P16401 | H1-5 | S116 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S113 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16591 | FER | S715 | ochoa | Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}. |
| P17480 | UBTF | S584 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P18583 | SON | S1702 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P25101 | EDNRA | S391 | psp | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| P27797 | CALR | S231 | ochoa | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| P27816 | MAP4 | S384 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28370 | SMARCA1 | S770 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) | [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}. |
| P29401 | TKT | S280 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P31327 | CPS1 | S1090 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P35611 | ADD1 | S483 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P41235 | HNF4A | S142 | ochoa|psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P42680 | TEC | T520 | ochoa | Tyrosine-protein kinase Tec (EC 2.7.10.2) | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC also regulates FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269|PubMed:10518561, ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:9753425}. |
| P42684 | ABL2 | T440 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46013 | MKI67 | S330 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1291 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49748 | ACADVL | S57 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P49758 | RGS6 | S244 | ochoa | Regulator of G-protein signaling 6 (RGS6) (S914) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). {ECO:0000269|PubMed:10521509}. |
| P51451 | BLK | T390 | ochoa | Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). {ECO:0000250|UniProtKB:P16277, ECO:0000269|PubMed:19667185, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:8756631}. |
| P51659 | HSD17B4 | S291 | ochoa | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P55196 | AFDN | S589 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P57078 | RIPK4 | S359 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P61964 | WDR5 | S22 | ochoa | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| P78347 | GTF2I | S146 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P84101 | SERF2 | S41 | ochoa | Small EDRK-rich factor 2 (Gastric cancer-related protein VRG107) (Protein 4F5-related) (4F5rel) (h4F5rel) | Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (PubMed:20723760). {ECO:0000269|PubMed:20723760}. |
| Q00341 | HDLBP | S756 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00765 | REEP5 | S154 | ochoa | Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2) | Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. {ECO:0000250|UniProtKB:Q60870}. |
| Q04912 | MST1R | Y1239 | ochoa|psp | Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. {ECO:0000269|PubMed:18836480, ECO:0000269|PubMed:7939629, ECO:0000269|PubMed:9764835}. |
| Q05397 | PTK2 | Y577 | ochoa|psp | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q06187 | BTK | T552 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08357 | SLC20A2 | S261 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08881 | ITK | T513 | ochoa | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q12765 | SCRN1 | S322 | ochoa | Secernin-1 | Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). {ECO:0000250}. |
| Q13164 | MAPK7 | S496 | psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q13428 | TCOF1 | S1050 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13586 | STIM1 | S667 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14289 | PTK2B | Y580 | ochoa|psp | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14500 | KCNJ12 | S64 | psp | ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12) | Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:12417321, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}. |
| Q14541 | HNF4G | S94 | ochoa | Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2) | Transcription factor. Has a lower transcription activation potential than HNF4-alpha. |
| Q15084 | PDIA6 | S230 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15303 | ERBB4 | S1129 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q15746 | MYLK | S145 | psp | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16666 | IFI16 | S106 | ochoa|psp | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q2KHR3 | QSER1 | S973 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q4V9L6 | TMEM119 | S125 | ochoa | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}. |
| Q5JTH9 | RRP12 | S460 | ochoa | RRP12-like protein | None |
| Q5T200 | ZC3H13 | S1065 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T481 | RBM20 | S801 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5T7P8 | SYT6 | T418 | psp | Synaptotagmin-6 (Synaptotagmin VI) (SytVI) | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}. |
| Q5VTB9 | RNF220 | S194 | ochoa | E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220) | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658, PubMed:33964137). Plays a critical role in the regulation of nuclear lamina (PubMed:33964137). {ECO:0000250|UniProtKB:Q6PDX6, ECO:0000269|PubMed:25266658, ECO:0000269|PubMed:33964137}. |
| Q6ZNJ1 | NBEAL2 | S1640 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q8IZT6 | ASPM | S570 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N4S0 | CCDC82 | S220 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8NG31 | KNL1 | S530 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TEQ0 | SNX29 | S278 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8WXE1 | ATRIP | S221 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q92785 | DPF2 | S200 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92793 | CREBBP | S1072 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q99956 | DUSP9 | S262 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q9BTC0 | DIDO1 | S206 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BX63 | BRIP1 | S1162 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9C0C9 | UBE2O | S407 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H2P0 | ADNP | S1032 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H329 | EPB41L4B | S428 | ochoa | Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}. |
| Q9HC77 | CPAP | S663 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HDC5 | JPH1 | S533 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NQX7 | ITM2C | S30 | ochoa | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}. |
| Q9NYD6 | HOXC10 | S219 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9UBC2 | EPS15L1 | S654 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UKV3 | ACIN1 | S522 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKX2 | MYH2 | S424 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UM73 | ALK | Y1507 | psp | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
| Q9UMS6 | SYNPO2 | S274 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| V9GYH0 | None | S24 | ochoa | Homeobox domain-containing protein | None |
| P30101 | PDIA3 | S98 | Sugiyama | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| Q15648 | MED1 | S935 | Sugiyama | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| O15075 | DCLK1 | S438 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| Q15181 | PPA1 | Y90 | Sugiyama | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| P63151 | PPP2R2A | S412 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| Q66LE6 | PPP2R2D | S418 | Sugiyama | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity). {ECO:0000250|UniProtKB:Q7ZX64, ECO:0000250|UniProtKB:Q925E7}. |
| P31947 | SFN | S149 | Sugiyama | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| Q9H2U2 | PPA2 | Y138 | Sugiyama | Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2) | Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). {ECO:0000269|PubMed:27523597, ECO:0000269|PubMed:27523598}. |
| P22102 | GART | S88 | Sugiyama | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| Q8NBS9 | TXNDC5 | S129 | Sugiyama | Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) | Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. {ECO:0000250|UniProtKB:Q91W90}. |
| P18887 | XRCC1 | S145 | Sugiyama | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| O95218 | ZRANB2 | S75 | Sugiyama | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| Q01082 | SPTBN1 | S446 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q13043 | STK4 | S75 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q16584 | MAP3K11 | S160 | Sugiyama | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16654 | PDK4 | S390 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:18658136, ECO:0000269|PubMed:21816445, ECO:0000269|PubMed:21852536}. |
| Q9Y4G6 | TLN2 | T2205 | Sugiyama | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9H4B4 | PLK3 | S86 | Sugiyama | Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-210990 | PECAM1 interactions | 6.749421e-09 | 8.171 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.220952e-07 | 6.653 |
| R-HSA-1433557 | Signaling by SCF-KIT | 7.890029e-07 | 6.103 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.060286e-06 | 5.975 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 1.395651e-06 | 5.855 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 4.638036e-06 | 5.334 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 5.190985e-06 | 5.285 |
| R-HSA-186712 | Regulation of beta-cell development | 4.688021e-06 | 5.329 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 8.938668e-06 | 5.049 |
| R-HSA-9669938 | Signaling by KIT in disease | 8.938668e-06 | 5.049 |
| R-HSA-75153 | Apoptotic execution phase | 1.620426e-05 | 4.790 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.491365e-05 | 4.604 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.491365e-05 | 4.604 |
| R-HSA-9664407 | Parasite infection | 2.491365e-05 | 4.604 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 3.017881e-05 | 4.520 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.443042e-05 | 4.264 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.786964e-05 | 4.238 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.746037e-05 | 4.171 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.028827e-04 | 3.988 |
| R-HSA-164944 | Nef and signal transduction | 9.971986e-05 | 4.001 |
| R-HSA-912631 | Regulation of signaling by CBL | 9.537890e-05 | 4.021 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.192934e-04 | 3.923 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.326504e-04 | 3.877 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.369863e-04 | 3.863 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.512508e-04 | 3.820 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.641205e-04 | 3.785 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.305325e-04 | 3.637 |
| R-HSA-8939211 | ESR-mediated signaling | 2.156627e-04 | 3.666 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.237512e-04 | 3.650 |
| R-HSA-9620244 | Long-term potentiation | 2.520096e-04 | 3.599 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.514293e-04 | 3.600 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.703746e-04 | 3.568 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.921755e-04 | 3.534 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.188354e-04 | 3.496 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.480751e-04 | 3.458 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.680836e-04 | 3.434 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.556493e-04 | 3.341 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.556493e-04 | 3.341 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.556493e-04 | 3.341 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 4.425631e-04 | 3.354 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.009852e-04 | 3.397 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.532630e-04 | 3.344 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.048006e-04 | 3.297 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.795649e-04 | 3.319 |
| R-HSA-354192 | Integrin signaling | 5.948569e-04 | 3.226 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.583670e-04 | 3.253 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.128149e-04 | 3.213 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.598450e-04 | 3.252 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 6.352451e-04 | 3.197 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.900481e-04 | 3.161 |
| R-HSA-1640170 | Cell Cycle | 7.088303e-04 | 3.149 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 7.487910e-04 | 3.126 |
| R-HSA-391160 | Signal regulatory protein family interactions | 7.487910e-04 | 3.126 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 8.744879e-04 | 3.058 |
| R-HSA-418885 | DCC mediated attractive signaling | 8.744879e-04 | 3.058 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.012825e-03 | 2.994 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.164273e-03 | 2.934 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.164273e-03 | 2.934 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.271501e-03 | 2.896 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.276870e-03 | 2.894 |
| R-HSA-9607240 | FLT3 Signaling | 1.276870e-03 | 2.894 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.329287e-03 | 2.876 |
| R-HSA-3928664 | Ephrin signaling | 1.508307e-03 | 2.822 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.493636e-03 | 2.826 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.445293e-03 | 2.840 |
| R-HSA-162582 | Signal Transduction | 1.540594e-03 | 2.812 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.564825e-03 | 2.806 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.924015e-03 | 2.716 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.829036e-03 | 2.738 |
| R-HSA-373753 | Nephrin family interactions | 1.910033e-03 | 2.719 |
| R-HSA-5693538 | Homology Directed Repair | 1.875801e-03 | 2.727 |
| R-HSA-69236 | G1 Phase | 1.707430e-03 | 2.768 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.707430e-03 | 2.768 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.904103e-03 | 2.720 |
| R-HSA-1500931 | Cell-Cell communication | 1.656872e-03 | 2.781 |
| R-HSA-109581 | Apoptosis | 1.927385e-03 | 2.715 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.875801e-03 | 2.727 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.090023e-03 | 2.680 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 2.157739e-03 | 2.666 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 2.157739e-03 | 2.666 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 2.157739e-03 | 2.666 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.627709e-03 | 2.580 |
| R-HSA-9658195 | Leishmania infection | 2.723062e-03 | 2.565 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.723062e-03 | 2.565 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.187098e-03 | 2.497 |
| R-HSA-73884 | Base Excision Repair | 2.864743e-03 | 2.543 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.187098e-03 | 2.497 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.899084e-03 | 2.538 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.387424e-03 | 2.470 |
| R-HSA-2029481 | FCGR activation | 3.387424e-03 | 2.470 |
| R-HSA-422475 | Axon guidance | 3.441111e-03 | 2.463 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.814306e-03 | 2.419 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 4.321183e-03 | 2.364 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.887435e-03 | 2.311 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.909949e-03 | 2.309 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.511716e-03 | 2.346 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.909949e-03 | 2.309 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 5.195877e-03 | 2.284 |
| R-HSA-2424491 | DAP12 signaling | 5.281503e-03 | 2.277 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.281503e-03 | 2.277 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 5.281503e-03 | 2.277 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.281503e-03 | 2.277 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.364919e-03 | 2.270 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.379830e-03 | 2.269 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.559638e-03 | 2.255 |
| R-HSA-9675108 | Nervous system development | 5.792615e-03 | 2.237 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 6.125639e-03 | 2.213 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 6.144815e-03 | 2.211 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 6.576152e-03 | 2.182 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.528220e-03 | 2.185 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.488841e-03 | 2.126 |
| R-HSA-5357801 | Programmed Cell Death | 6.445187e-03 | 2.191 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.793117e-03 | 2.108 |
| R-HSA-9700649 | Drug resistance of ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 9.579654e-03 | 2.019 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 9.422367e-03 | 2.026 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 9.422367e-03 | 2.026 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.569310e-03 | 2.067 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 8.043897e-03 | 2.095 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 8.466179e-03 | 2.072 |
| R-HSA-114604 | GPVI-mediated activation cascade | 8.572490e-03 | 2.067 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 9.422367e-03 | 2.026 |
| R-HSA-74160 | Gene expression (Transcription) | 8.347639e-03 | 2.078 |
| R-HSA-9020558 | Interleukin-2 signaling | 8.259513e-03 | 2.083 |
| R-HSA-8941326 | RUNX2 regulates bone development | 8.572490e-03 | 2.067 |
| R-HSA-212436 | Generic Transcription Pathway | 8.682537e-03 | 2.061 |
| R-HSA-8875878 | MET promotes cell motility | 9.689680e-03 | 2.014 |
| R-HSA-201556 | Signaling by ALK | 1.027857e-02 | 1.988 |
| R-HSA-73894 | DNA Repair | 1.177327e-02 | 1.929 |
| R-HSA-194138 | Signaling by VEGF | 1.187241e-02 | 1.925 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.195198e-02 | 1.923 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.195198e-02 | 1.923 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.195198e-02 | 1.923 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.195198e-02 | 1.923 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 1.221004e-02 | 1.913 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.292489e-02 | 1.889 |
| R-HSA-2172127 | DAP12 interactions | 1.424369e-02 | 1.846 |
| R-HSA-373752 | Netrin-1 signaling | 1.424369e-02 | 1.846 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.435732e-02 | 1.843 |
| R-HSA-1280218 | Adaptive Immune System | 1.471878e-02 | 1.832 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.474424e-02 | 1.831 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.497744e-02 | 1.825 |
| R-HSA-774815 | Nucleosome assembly | 1.497744e-02 | 1.825 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.906813e-02 | 1.720 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.906813e-02 | 1.720 |
| R-HSA-9734091 | Drug-mediated inhibition of MET activation | 1.906813e-02 | 1.720 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.906813e-02 | 1.720 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.906813e-02 | 1.720 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.906813e-02 | 1.720 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.573221e-02 | 1.803 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.573221e-02 | 1.803 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.573221e-02 | 1.803 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.573221e-02 | 1.803 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.536597e-02 | 1.813 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.778833e-02 | 1.750 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.940152e-02 | 1.712 |
| R-HSA-9831926 | Nephron development | 2.107376e-02 | 1.676 |
| R-HSA-1266738 | Developmental Biology | 2.208094e-02 | 1.656 |
| R-HSA-2262752 | Cellular responses to stress | 2.288286e-02 | 1.640 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.334197e-02 | 1.632 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.435622e-02 | 1.613 |
| R-HSA-177929 | Signaling by EGFR | 2.444641e-02 | 1.612 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.459036e-02 | 1.609 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.643224e-02 | 1.578 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.747566e-02 | 1.561 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.832822e-02 | 1.548 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.832822e-02 | 1.548 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.832822e-02 | 1.548 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.832822e-02 | 1.548 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 2.846628e-02 | 1.546 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 2.846628e-02 | 1.546 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.944437e-02 | 1.531 |
| R-HSA-198765 | Signalling to ERK5 | 3.777496e-02 | 1.423 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.077479e-02 | 1.390 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.148897e-02 | 1.382 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.857859e-02 | 1.414 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.648396e-02 | 1.438 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.427117e-02 | 1.465 |
| R-HSA-373755 | Semaphorin interactions | 3.181150e-02 | 1.497 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 3.684725e-02 | 1.434 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.528449e-02 | 1.452 |
| R-HSA-525793 | Myogenesis | 3.857859e-02 | 1.414 |
| R-HSA-73886 | Chromosome Maintenance | 4.232633e-02 | 1.373 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.077479e-02 | 1.390 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.077479e-02 | 1.390 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 3.897318e-02 | 1.409 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.857859e-02 | 1.414 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 3.900028e-02 | 1.409 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 3.900028e-02 | 1.409 |
| R-HSA-8848021 | Signaling by PTK6 | 3.181150e-02 | 1.497 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.181150e-02 | 1.497 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.363311e-02 | 1.473 |
| R-HSA-2559583 | Cellular Senescence | 4.427974e-02 | 1.354 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.530448e-02 | 1.344 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.530448e-02 | 1.344 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 4.530448e-02 | 1.344 |
| R-HSA-8875513 | MET interacts with TNS proteins | 4.699502e-02 | 1.328 |
| R-HSA-1296053 | Classical Kir channels | 4.699502e-02 | 1.328 |
| R-HSA-8865999 | MET activates PTPN11 | 4.699502e-02 | 1.328 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 4.699502e-02 | 1.328 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 4.699502e-02 | 1.328 |
| R-HSA-8875791 | MET activates STAT3 | 4.699502e-02 | 1.328 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.763585e-02 | 1.322 |
| R-HSA-109582 | Hemostasis | 4.790528e-02 | 1.320 |
| R-HSA-69481 | G2/M Checkpoints | 4.926980e-02 | 1.307 |
| R-HSA-114608 | Platelet degranulation | 4.926980e-02 | 1.307 |
| R-HSA-1538133 | G0 and Early G1 | 5.242643e-02 | 1.280 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.322336e-02 | 1.274 |
| R-HSA-6806834 | Signaling by MET | 5.393707e-02 | 1.268 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.393707e-02 | 1.268 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.541918e-02 | 1.256 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 5.612730e-02 | 1.251 |
| R-HSA-191650 | Regulation of gap junction activity | 5.612730e-02 | 1.251 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 5.612730e-02 | 1.251 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.680418e-02 | 1.246 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.842120e-02 | 1.233 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.991676e-02 | 1.222 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.991676e-02 | 1.222 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.991676e-02 | 1.222 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.991676e-02 | 1.222 |
| R-HSA-5673000 | RAF activation | 5.991676e-02 | 1.222 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.991676e-02 | 1.222 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 5.991676e-02 | 1.222 |
| R-HSA-168249 | Innate Immune System | 6.106146e-02 | 1.214 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 6.517263e-02 | 1.186 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 6.517263e-02 | 1.186 |
| R-HSA-9652817 | Signaling by MAPK mutants | 7.413183e-02 | 1.130 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 8.300571e-02 | 1.081 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 9.179509e-02 | 1.037 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 7.589799e-02 | 1.120 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 9.179509e-02 | 1.037 |
| R-HSA-8852405 | Signaling by MST1 | 7.413183e-02 | 1.130 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.149461e-02 | 1.089 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 9.179509e-02 | 1.037 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.774903e-02 | 1.169 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.149461e-02 | 1.089 |
| R-HSA-6806942 | MET Receptor Activation | 8.300571e-02 | 1.081 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 7.043138e-02 | 1.152 |
| R-HSA-3214847 | HATs acetylate histones | 9.080134e-02 | 1.042 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 8.300571e-02 | 1.081 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.249080e-02 | 1.204 |
| R-HSA-8866376 | Reelin signalling pathway | 6.517263e-02 | 1.186 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 7.413183e-02 | 1.130 |
| R-HSA-418886 | Netrin mediated repulsion signals | 9.179509e-02 | 1.037 |
| R-HSA-202433 | Generation of second messenger molecules | 7.589799e-02 | 1.120 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.451811e-02 | 1.190 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 7.589799e-02 | 1.120 |
| R-HSA-5260271 | Diseases of Immune System | 7.589799e-02 | 1.120 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 6.517263e-02 | 1.186 |
| R-HSA-8964011 | HDL clearance | 8.300571e-02 | 1.081 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 9.179509e-02 | 1.037 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 8.433952e-02 | 1.074 |
| R-HSA-73928 | Depyrimidination | 8.433952e-02 | 1.074 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 7.413183e-02 | 1.130 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 9.179509e-02 | 1.037 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.734854e-02 | 1.172 |
| R-HSA-166520 | Signaling by NTRKs | 7.751407e-02 | 1.111 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 7.314800e-02 | 1.136 |
| R-HSA-8853659 | RET signaling | 6.510187e-02 | 1.186 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 6.510187e-02 | 1.186 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.471391e-02 | 1.189 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 6.517263e-02 | 1.186 |
| R-HSA-451927 | Interleukin-2 family signaling | 7.589799e-02 | 1.120 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.470042e-02 | 1.127 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.191677e-02 | 1.208 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 9.601039e-02 | 1.018 |
| R-HSA-9675135 | Diseases of DNA repair | 9.601039e-02 | 1.018 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.874083e-02 | 1.006 |
| R-HSA-8875656 | MET receptor recycling | 1.005008e-01 | 0.998 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.005008e-01 | 0.998 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.022876e-01 | 0.990 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.022876e-01 | 0.990 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 1.050469e-01 | 0.979 |
| R-HSA-9766229 | Degradation of CDH1 | 1.050469e-01 | 0.979 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.091235e-01 | 0.962 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.091235e-01 | 0.962 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.091235e-01 | 0.962 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.091235e-01 | 0.962 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.091235e-01 | 0.962 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.091235e-01 | 0.962 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.091235e-01 | 0.962 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.176641e-01 | 0.929 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.176641e-01 | 0.929 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.345021e-01 | 0.871 |
| R-HSA-202670 | ERKs are inactivated | 1.345021e-01 | 0.871 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.345021e-01 | 0.871 |
| R-HSA-8851805 | MET activates RAS signaling | 1.428010e-01 | 0.845 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.428010e-01 | 0.845 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.428010e-01 | 0.845 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.591622e-01 | 0.798 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.672261e-01 | 0.777 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.672261e-01 | 0.777 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 1.672261e-01 | 0.777 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.064075e-01 | 0.685 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.140211e-01 | 0.670 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.140211e-01 | 0.670 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.140211e-01 | 0.670 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.140211e-01 | 0.670 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.140211e-01 | 0.670 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.140211e-01 | 0.670 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.143034e-01 | 0.942 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.174343e-01 | 0.930 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.399160e-01 | 0.854 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.564954e-01 | 0.805 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.510208e-01 | 0.821 |
| R-HSA-1221632 | Meiotic synapsis | 1.174343e-01 | 0.930 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.752132e-01 | 0.756 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.831242e-01 | 0.737 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.428010e-01 | 0.845 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.768448e-01 | 0.752 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.010643e-01 | 0.697 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.420781e-01 | 0.847 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.941011e-01 | 0.712 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.345021e-01 | 0.871 |
| R-HSA-198753 | ERK/MAPK targets | 2.215622e-01 | 0.655 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.632288e-01 | 0.787 |
| R-HSA-192814 | vRNA Synthesis | 1.261234e-01 | 0.899 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 1.752132e-01 | 0.756 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.428010e-01 | 0.845 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.987206e-01 | 0.702 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.261234e-01 | 0.899 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.591622e-01 | 0.798 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.672261e-01 | 0.777 |
| R-HSA-171007 | p38MAPK events | 1.672261e-01 | 0.777 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.672261e-01 | 0.777 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.909597e-01 | 0.719 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 1.987206e-01 | 0.702 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.955647e-01 | 0.709 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.831242e-01 | 0.737 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.010643e-01 | 0.697 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.376684e-01 | 0.861 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.376684e-01 | 0.861 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.443006e-01 | 0.841 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 1.428010e-01 | 0.845 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.752132e-01 | 0.756 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.443006e-01 | 0.841 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.261234e-01 | 0.899 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.510208e-01 | 0.821 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.672261e-01 | 0.777 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.672261e-01 | 0.777 |
| R-HSA-2028269 | Signaling by Hippo | 1.909597e-01 | 0.719 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.987206e-01 | 0.702 |
| R-HSA-167044 | Signalling to RAS | 2.215622e-01 | 0.655 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.617048e-01 | 0.791 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.155407e-01 | 0.666 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.831242e-01 | 0.737 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.987206e-01 | 0.702 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 1.205868e-01 | 0.919 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.333984e-01 | 0.875 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.176641e-01 | 0.929 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.672261e-01 | 0.777 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.140211e-01 | 0.670 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.150739e-01 | 0.667 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.080564e-01 | 0.682 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.215622e-01 | 0.655 |
| R-HSA-8963896 | HDL assembly | 1.591622e-01 | 0.798 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.064075e-01 | 0.685 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.215622e-01 | 0.655 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.064075e-01 | 0.685 |
| R-HSA-168256 | Immune System | 2.186766e-01 | 0.660 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.672261e-01 | 0.777 |
| R-HSA-180292 | GAB1 signalosome | 1.987206e-01 | 0.702 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.752132e-01 | 0.756 |
| R-HSA-5621480 | Dectin-2 family | 1.301666e-01 | 0.886 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.487802e-01 | 0.827 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.122456e-01 | 0.950 |
| R-HSA-216083 | Integrin cell surface interactions | 2.010643e-01 | 0.697 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.498177e-01 | 0.824 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.909597e-01 | 0.719 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.880082e-01 | 0.726 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.301666e-01 | 0.886 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.734235e-01 | 0.761 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.045569e-01 | 0.689 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.205420e-01 | 0.657 |
| R-HSA-168268 | Virus Assembly and Release | 1.752132e-01 | 0.756 |
| R-HSA-379724 | tRNA Aminoacylation | 1.399160e-01 | 0.854 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 1.399160e-01 | 0.854 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.185911e-01 | 0.660 |
| R-HSA-418990 | Adherens junctions interactions | 1.977221e-01 | 0.704 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 2.215622e-01 | 0.655 |
| R-HSA-9707616 | Heme signaling | 1.465013e-01 | 0.834 |
| R-HSA-9830369 | Kidney development | 1.632288e-01 | 0.787 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.376684e-01 | 0.861 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.115622e-01 | 0.675 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.221133e-01 | 0.653 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.221133e-01 | 0.653 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.230515e-01 | 0.652 |
| R-HSA-1500620 | Meiosis | 2.256402e-01 | 0.647 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.290314e-01 | 0.640 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.290314e-01 | 0.640 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.290314e-01 | 0.640 |
| R-HSA-70268 | Pyruvate metabolism | 2.362445e-01 | 0.627 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.363076e-01 | 0.627 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.364293e-01 | 0.626 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.364293e-01 | 0.626 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.437567e-01 | 0.613 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.437567e-01 | 0.613 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.458779e-01 | 0.609 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.504244e-01 | 0.601 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.504244e-01 | 0.601 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.510143e-01 | 0.600 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.510143e-01 | 0.600 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.510143e-01 | 0.600 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.510143e-01 | 0.600 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.510143e-01 | 0.600 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.575252e-01 | 0.589 |
| R-HSA-1643685 | Disease | 2.577146e-01 | 0.589 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.582027e-01 | 0.588 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 2.582027e-01 | 0.588 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 2.582027e-01 | 0.588 |
| R-HSA-1296059 | G protein gated Potassium channels | 2.582027e-01 | 0.588 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.582027e-01 | 0.588 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.582027e-01 | 0.588 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.582027e-01 | 0.588 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 2.582027e-01 | 0.588 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.582027e-01 | 0.588 |
| R-HSA-4839726 | Chromatin organization | 2.609050e-01 | 0.584 |
| R-HSA-421270 | Cell-cell junction organization | 2.651205e-01 | 0.577 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.653225e-01 | 0.576 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.653225e-01 | 0.576 |
| R-HSA-70635 | Urea cycle | 2.653225e-01 | 0.576 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.653225e-01 | 0.576 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.723744e-01 | 0.565 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.723744e-01 | 0.565 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.723744e-01 | 0.565 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.723744e-01 | 0.565 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.723744e-01 | 0.565 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.752864e-01 | 0.560 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 2.752864e-01 | 0.560 |
| R-HSA-157579 | Telomere Maintenance | 2.788376e-01 | 0.555 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.788376e-01 | 0.555 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.793590e-01 | 0.554 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.794397e-01 | 0.554 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.820422e-01 | 0.550 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.820422e-01 | 0.550 |
| R-HSA-449147 | Signaling by Interleukins | 2.842332e-01 | 0.546 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.859364e-01 | 0.544 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.862770e-01 | 0.543 |
| R-HSA-5334118 | DNA methylation | 2.862770e-01 | 0.543 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.862770e-01 | 0.543 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.862770e-01 | 0.543 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.862770e-01 | 0.543 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.930284e-01 | 0.533 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 2.931291e-01 | 0.533 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.931291e-01 | 0.533 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.931291e-01 | 0.533 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.965712e-01 | 0.528 |
| R-HSA-182971 | EGFR downregulation | 2.999158e-01 | 0.523 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.999158e-01 | 0.523 |
| R-HSA-186763 | Downstream signal transduction | 2.999158e-01 | 0.523 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.014088e-01 | 0.521 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.066377e-01 | 0.513 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.066377e-01 | 0.513 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.066377e-01 | 0.513 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.066377e-01 | 0.513 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.066377e-01 | 0.513 |
| R-HSA-9833110 | RSV-host interactions | 3.071832e-01 | 0.513 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.107141e-01 | 0.508 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.132955e-01 | 0.504 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.132955e-01 | 0.504 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.132955e-01 | 0.504 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.132955e-01 | 0.504 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.132955e-01 | 0.504 |
| R-HSA-9733709 | Cardiogenesis | 3.132955e-01 | 0.504 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.132955e-01 | 0.504 |
| R-HSA-418346 | Platelet homeostasis | 3.142415e-01 | 0.503 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.198898e-01 | 0.495 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.198898e-01 | 0.495 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.198898e-01 | 0.495 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.198898e-01 | 0.495 |
| R-HSA-446728 | Cell junction organization | 3.230327e-01 | 0.491 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.264212e-01 | 0.486 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.264212e-01 | 0.486 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.264212e-01 | 0.486 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.264212e-01 | 0.486 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.264212e-01 | 0.486 |
| R-HSA-392518 | Signal amplification | 3.264212e-01 | 0.486 |
| R-HSA-5205647 | Mitophagy | 3.264212e-01 | 0.486 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.264212e-01 | 0.486 |
| R-HSA-202403 | TCR signaling | 3.283098e-01 | 0.484 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.291398e-01 | 0.483 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.328902e-01 | 0.478 |
| R-HSA-187687 | Signalling to ERKs | 3.328902e-01 | 0.478 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.388111e-01 | 0.470 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.392975e-01 | 0.469 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.392975e-01 | 0.469 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.392975e-01 | 0.469 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.422478e-01 | 0.466 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.456437e-01 | 0.461 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.456437e-01 | 0.461 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.456437e-01 | 0.461 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 3.456437e-01 | 0.461 |
| R-HSA-68886 | M Phase | 3.472446e-01 | 0.459 |
| R-HSA-73927 | Depurination | 3.519293e-01 | 0.454 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 3.519293e-01 | 0.454 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.519293e-01 | 0.454 |
| R-HSA-373760 | L1CAM interactions | 3.562005e-01 | 0.448 |
| R-HSA-71336 | Pentose phosphate pathway | 3.581549e-01 | 0.446 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.581549e-01 | 0.446 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.596596e-01 | 0.444 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.605669e-01 | 0.443 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.643211e-01 | 0.439 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.643211e-01 | 0.439 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.643211e-01 | 0.439 |
| R-HSA-3371568 | Attenuation phase | 3.643211e-01 | 0.439 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 3.643211e-01 | 0.439 |
| R-HSA-68875 | Mitotic Prophase | 3.699958e-01 | 0.432 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.704284e-01 | 0.431 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.704284e-01 | 0.431 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.704284e-01 | 0.431 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.704284e-01 | 0.431 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.704284e-01 | 0.431 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 3.764774e-01 | 0.424 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.764774e-01 | 0.424 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.802665e-01 | 0.420 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.824687e-01 | 0.417 |
| R-HSA-991365 | Activation of GABAB receptors | 3.824687e-01 | 0.417 |
| R-HSA-977444 | GABA B receptor activation | 3.824687e-01 | 0.417 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.824687e-01 | 0.417 |
| R-HSA-5663205 | Infectious disease | 3.829598e-01 | 0.417 |
| R-HSA-397014 | Muscle contraction | 3.866037e-01 | 0.413 |
| R-HSA-9710421 | Defective pyroptosis | 3.884028e-01 | 0.411 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.884028e-01 | 0.411 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.942802e-01 | 0.404 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.942802e-01 | 0.404 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.001015e-01 | 0.398 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.001015e-01 | 0.398 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.001015e-01 | 0.398 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.001015e-01 | 0.398 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 4.001015e-01 | 0.398 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.001015e-01 | 0.398 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.005934e-01 | 0.397 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.058672e-01 | 0.392 |
| R-HSA-1474165 | Reproduction | 4.106411e-01 | 0.387 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 4.115778e-01 | 0.386 |
| R-HSA-437239 | Recycling pathway of L1 | 4.115778e-01 | 0.386 |
| R-HSA-9843745 | Adipogenesis | 4.139723e-01 | 0.383 |
| R-HSA-5576891 | Cardiac conduction | 4.139723e-01 | 0.383 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.172339e-01 | 0.380 |
| R-HSA-9634597 | GPER1 signaling | 4.172339e-01 | 0.380 |
| R-HSA-9909396 | Circadian clock | 4.172941e-01 | 0.380 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.228360e-01 | 0.374 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.228360e-01 | 0.374 |
| R-HSA-162906 | HIV Infection | 4.251671e-01 | 0.371 |
| R-HSA-912446 | Meiotic recombination | 4.338802e-01 | 0.363 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.338802e-01 | 0.363 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.338802e-01 | 0.363 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.370239e-01 | 0.359 |
| R-HSA-1474244 | Extracellular matrix organization | 4.378616e-01 | 0.359 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.393233e-01 | 0.357 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.393233e-01 | 0.357 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.428889e-01 | 0.354 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.447143e-01 | 0.352 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.447143e-01 | 0.352 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.447143e-01 | 0.352 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.553425e-01 | 0.342 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.553425e-01 | 0.342 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.605805e-01 | 0.337 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.605805e-01 | 0.337 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.605805e-01 | 0.337 |
| R-HSA-5578775 | Ion homeostasis | 4.605805e-01 | 0.337 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.605805e-01 | 0.337 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.605805e-01 | 0.337 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.605805e-01 | 0.337 |
| R-HSA-9033241 | Peroxisomal protein import | 4.759962e-01 | 0.322 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.810368e-01 | 0.318 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.810368e-01 | 0.318 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.810368e-01 | 0.318 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.810368e-01 | 0.318 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.810368e-01 | 0.318 |
| R-HSA-977443 | GABA receptor activation | 4.810368e-01 | 0.318 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.810368e-01 | 0.318 |
| R-HSA-450294 | MAP kinase activation | 4.860293e-01 | 0.313 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.860293e-01 | 0.313 |
| R-HSA-186797 | Signaling by PDGF | 4.909740e-01 | 0.309 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.909740e-01 | 0.309 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.958715e-01 | 0.305 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.958715e-01 | 0.305 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.958715e-01 | 0.305 |
| R-HSA-1989781 | PPARA activates gene expression | 4.970071e-01 | 0.304 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 5.007222e-01 | 0.300 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.007222e-01 | 0.300 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.030845e-01 | 0.298 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.055265e-01 | 0.296 |
| R-HSA-112316 | Neuronal System | 5.086783e-01 | 0.294 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.102848e-01 | 0.292 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.149977e-01 | 0.288 |
| R-HSA-416476 | G alpha (q) signalling events | 5.161680e-01 | 0.287 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.196655e-01 | 0.284 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.288676e-01 | 0.277 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.288676e-01 | 0.277 |
| R-HSA-448424 | Interleukin-17 signaling | 5.288676e-01 | 0.277 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.288676e-01 | 0.277 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.334027e-01 | 0.273 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.378945e-01 | 0.269 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.378945e-01 | 0.269 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.378945e-01 | 0.269 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.423433e-01 | 0.266 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.423433e-01 | 0.266 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.423433e-01 | 0.266 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.467495e-01 | 0.262 |
| R-HSA-380287 | Centrosome maturation | 5.511136e-01 | 0.259 |
| R-HSA-8852135 | Protein ubiquitination | 5.511136e-01 | 0.259 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.511136e-01 | 0.259 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.511136e-01 | 0.259 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.511136e-01 | 0.259 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.528030e-01 | 0.257 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.554360e-01 | 0.255 |
| R-HSA-9659379 | Sensory processing of sound | 5.681565e-01 | 0.246 |
| R-HSA-168255 | Influenza Infection | 5.695010e-01 | 0.245 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.723157e-01 | 0.242 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.723157e-01 | 0.242 |
| R-HSA-977225 | Amyloid fiber formation | 5.764352e-01 | 0.239 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.803824e-01 | 0.236 |
| R-HSA-69275 | G2/M Transition | 5.884113e-01 | 0.230 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.885586e-01 | 0.230 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 5.885586e-01 | 0.230 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.925226e-01 | 0.227 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.937008e-01 | 0.226 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.964486e-01 | 0.224 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.964486e-01 | 0.224 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.041884e-01 | 0.219 |
| R-HSA-68877 | Mitotic Prometaphase | 6.067039e-01 | 0.217 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.080027e-01 | 0.216 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.080027e-01 | 0.216 |
| R-HSA-9663891 | Selective autophagy | 6.080027e-01 | 0.216 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.139449e-01 | 0.212 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.155222e-01 | 0.211 |
| R-HSA-202424 | Downstream TCR signaling | 6.155222e-01 | 0.211 |
| R-HSA-391251 | Protein folding | 6.265336e-01 | 0.203 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.301340e-01 | 0.201 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.372316e-01 | 0.196 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.372316e-01 | 0.196 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.378151e-01 | 0.195 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.441939e-01 | 0.191 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.441939e-01 | 0.191 |
| R-HSA-1296071 | Potassium Channels | 6.441939e-01 | 0.191 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.441939e-01 | 0.191 |
| R-HSA-8957322 | Metabolism of steroids | 6.456459e-01 | 0.190 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.476251e-01 | 0.189 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.510234e-01 | 0.186 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.510234e-01 | 0.186 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.510234e-01 | 0.186 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.510234e-01 | 0.186 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.510234e-01 | 0.186 |
| R-HSA-190236 | Signaling by FGFR | 6.510234e-01 | 0.186 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.543891e-01 | 0.184 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.543891e-01 | 0.184 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.577226e-01 | 0.182 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.642941e-01 | 0.178 |
| R-HSA-68882 | Mitotic Anaphase | 6.647488e-01 | 0.177 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.670121e-01 | 0.176 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.675327e-01 | 0.176 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.707402e-01 | 0.173 |
| R-HSA-9824446 | Viral Infection Pathways | 6.730994e-01 | 0.172 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.770633e-01 | 0.169 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.801794e-01 | 0.167 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.832657e-01 | 0.165 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.832657e-01 | 0.165 |
| R-HSA-211000 | Gene Silencing by RNA | 6.832657e-01 | 0.165 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.863224e-01 | 0.163 |
| R-HSA-5419276 | Mitochondrial translation termination | 6.893498e-01 | 0.162 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.893498e-01 | 0.162 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.893498e-01 | 0.162 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.893498e-01 | 0.162 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.911064e-01 | 0.160 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.923481e-01 | 0.160 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.923481e-01 | 0.160 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.923481e-01 | 0.160 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.982588e-01 | 0.156 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.982588e-01 | 0.156 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.982588e-01 | 0.156 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.011717e-01 | 0.154 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.069140e-01 | 0.151 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.097438e-01 | 0.149 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.097438e-01 | 0.149 |
| R-HSA-157118 | Signaling by NOTCH | 7.157466e-01 | 0.145 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.288071e-01 | 0.137 |
| R-HSA-3371556 | Cellular response to heat stress | 7.288071e-01 | 0.137 |
| R-HSA-5688426 | Deubiquitination | 7.442213e-01 | 0.128 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.609700e-01 | 0.119 |
| R-HSA-163685 | Integration of energy metabolism | 7.723049e-01 | 0.112 |
| R-HSA-199991 | Membrane Trafficking | 7.753906e-01 | 0.110 |
| R-HSA-5368287 | Mitochondrial translation | 7.766879e-01 | 0.110 |
| R-HSA-388396 | GPCR downstream signalling | 7.817549e-01 | 0.107 |
| R-HSA-1632852 | Macroautophagy | 7.831056e-01 | 0.106 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.872820e-01 | 0.104 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.893401e-01 | 0.103 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.893691e-01 | 0.103 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.913784e-01 | 0.102 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.973766e-01 | 0.098 |
| R-HSA-9758941 | Gastrulation | 8.012799e-01 | 0.096 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.021233e-01 | 0.096 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.032034e-01 | 0.095 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.032034e-01 | 0.095 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.069951e-01 | 0.093 |
| R-HSA-9609507 | Protein localization | 8.088637e-01 | 0.092 |
| R-HSA-69306 | DNA Replication | 8.088637e-01 | 0.092 |
| R-HSA-72766 | Translation | 8.106211e-01 | 0.091 |
| R-HSA-73887 | Death Receptor Signaling | 8.107142e-01 | 0.091 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.125470e-01 | 0.090 |
| R-HSA-195721 | Signaling by WNT | 8.127044e-01 | 0.090 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.141161e-01 | 0.089 |
| R-HSA-9612973 | Autophagy | 8.143622e-01 | 0.089 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.214498e-01 | 0.085 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.282684e-01 | 0.082 |
| R-HSA-5619102 | SLC transporter disorders | 8.332121e-01 | 0.079 |
| R-HSA-418555 | G alpha (s) signalling events | 8.411392e-01 | 0.075 |
| R-HSA-6798695 | Neutrophil degranulation | 8.416092e-01 | 0.075 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.472104e-01 | 0.072 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.472104e-01 | 0.072 |
| R-HSA-372790 | Signaling by GPCR | 8.540515e-01 | 0.069 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.627433e-01 | 0.064 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.644268e-01 | 0.063 |
| R-HSA-983712 | Ion channel transport | 8.667002e-01 | 0.062 |
| R-HSA-5617833 | Cilium Assembly | 8.679938e-01 | 0.061 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.724807e-01 | 0.059 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.730446e-01 | 0.059 |
| R-HSA-9609690 | HCMV Early Events | 8.754975e-01 | 0.058 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.825774e-01 | 0.054 |
| R-HSA-72172 | mRNA Splicing | 8.859658e-01 | 0.053 |
| R-HSA-8951664 | Neddylation | 9.034108e-01 | 0.044 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.080166e-01 | 0.042 |
| R-HSA-15869 | Metabolism of nucleotides | 9.165856e-01 | 0.038 |
| R-HSA-9679506 | SARS-CoV Infections | 9.181482e-01 | 0.037 |
| R-HSA-418594 | G alpha (i) signalling events | 9.195913e-01 | 0.036 |
| R-HSA-8978868 | Fatty acid metabolism | 9.195913e-01 | 0.036 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.250971e-01 | 0.034 |
| R-HSA-9609646 | HCMV Infection | 9.272648e-01 | 0.033 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.359600e-01 | 0.029 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.452561e-01 | 0.024 |
| R-HSA-382551 | Transport of small molecules | 9.673272e-01 | 0.014 |
| R-HSA-597592 | Post-translational protein modification | 9.675121e-01 | 0.014 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.825248e-01 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.830352e-01 | 0.007 |
| R-HSA-8953854 | Metabolism of RNA | 9.900441e-01 | 0.004 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.904464e-01 | 0.004 |
| R-HSA-392499 | Metabolism of proteins | 9.906262e-01 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 9.974855e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.981192e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.998055e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999967e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.870 | 0.218 | 2 | 0.882 |
CLK3 |
0.867 | 0.214 | 1 | 0.760 |
MOS |
0.865 | 0.153 | 1 | 0.801 |
PRPK |
0.862 | 0.123 | -1 | 0.903 |
BMPR1B |
0.861 | 0.294 | 1 | 0.719 |
ERK5 |
0.858 | 0.247 | 1 | 0.830 |
PIM3 |
0.857 | 0.099 | -3 | 0.803 |
BMPR2 |
0.857 | 0.127 | -2 | 0.843 |
DSTYK |
0.857 | 0.147 | 2 | 0.908 |
NEK6 |
0.856 | 0.180 | -2 | 0.817 |
CDC7 |
0.853 | 0.009 | 1 | 0.759 |
CAMK1B |
0.853 | 0.024 | -3 | 0.817 |
GCN2 |
0.853 | 0.046 | 2 | 0.888 |
TGFBR2 |
0.853 | 0.146 | -2 | 0.845 |
TGFBR1 |
0.852 | 0.247 | -2 | 0.858 |
GRK7 |
0.850 | 0.210 | 1 | 0.654 |
RAF1 |
0.850 | -0.056 | 1 | 0.724 |
ATR |
0.849 | -0.028 | 1 | 0.735 |
ALK4 |
0.849 | 0.204 | -2 | 0.867 |
NEK7 |
0.848 | 0.055 | -3 | 0.780 |
BMPR1A |
0.847 | 0.267 | 1 | 0.689 |
PIM1 |
0.847 | 0.092 | -3 | 0.749 |
NLK |
0.847 | -0.029 | 1 | 0.720 |
CDKL1 |
0.847 | 0.011 | -3 | 0.746 |
ACVR2A |
0.846 | 0.203 | -2 | 0.830 |
CAMK2G |
0.846 | -0.026 | 2 | 0.856 |
NIK |
0.846 | -0.021 | -3 | 0.843 |
MLK1 |
0.846 | 0.022 | 2 | 0.863 |
CDKL5 |
0.846 | 0.105 | -3 | 0.729 |
ACVR2B |
0.846 | 0.203 | -2 | 0.834 |
ALK2 |
0.845 | 0.221 | -2 | 0.863 |
CAMLCK |
0.845 | 0.013 | -2 | 0.806 |
GRK1 |
0.844 | 0.087 | -2 | 0.743 |
IKKB |
0.844 | -0.041 | -2 | 0.674 |
SKMLCK |
0.844 | 0.028 | -2 | 0.807 |
ULK2 |
0.844 | -0.079 | 2 | 0.855 |
GRK6 |
0.844 | 0.031 | 1 | 0.725 |
KIS |
0.844 | 0.083 | 1 | 0.621 |
CHAK2 |
0.843 | 0.000 | -1 | 0.805 |
GRK5 |
0.843 | -0.069 | -3 | 0.825 |
NDR2 |
0.843 | 0.025 | -3 | 0.816 |
TBK1 |
0.843 | -0.083 | 1 | 0.616 |
PKR |
0.841 | 0.078 | 1 | 0.769 |
IKKA |
0.841 | 0.079 | -2 | 0.666 |
WNK1 |
0.840 | -0.015 | -2 | 0.785 |
DAPK2 |
0.840 | -0.038 | -3 | 0.812 |
GRK4 |
0.840 | 0.020 | -2 | 0.791 |
PKCD |
0.840 | 0.059 | 2 | 0.851 |
RSK2 |
0.840 | 0.032 | -3 | 0.727 |
PKN3 |
0.839 | -0.024 | -3 | 0.773 |
PRKD1 |
0.839 | 0.030 | -3 | 0.760 |
P70S6KB |
0.839 | 0.029 | -3 | 0.752 |
TLK2 |
0.839 | 0.099 | 1 | 0.698 |
NUAK2 |
0.839 | 0.000 | -3 | 0.795 |
PDHK4 |
0.839 | -0.357 | 1 | 0.737 |
ICK |
0.839 | 0.005 | -3 | 0.779 |
ATM |
0.838 | 0.034 | 1 | 0.664 |
MLK4 |
0.838 | 0.097 | 2 | 0.806 |
NDR1 |
0.838 | -0.015 | -3 | 0.799 |
HIPK4 |
0.838 | 0.005 | 1 | 0.718 |
IKKE |
0.838 | -0.111 | 1 | 0.610 |
ANKRD3 |
0.838 | -0.054 | 1 | 0.751 |
PRKD2 |
0.837 | 0.051 | -3 | 0.732 |
MLK2 |
0.837 | -0.036 | 2 | 0.875 |
MST4 |
0.837 | 0.001 | 2 | 0.880 |
MLK3 |
0.837 | 0.050 | 2 | 0.818 |
MTOR |
0.837 | -0.176 | 1 | 0.661 |
AMPKA1 |
0.837 | -0.013 | -3 | 0.809 |
PDHK1 |
0.836 | -0.255 | 1 | 0.732 |
TTBK2 |
0.836 | -0.056 | 2 | 0.812 |
NEK9 |
0.836 | -0.075 | 2 | 0.900 |
AURC |
0.836 | 0.104 | -2 | 0.659 |
DLK |
0.836 | -0.139 | 1 | 0.714 |
SRPK1 |
0.835 | 0.016 | -3 | 0.699 |
PLK1 |
0.835 | 0.024 | -2 | 0.784 |
PKN2 |
0.835 | -0.017 | -3 | 0.788 |
HUNK |
0.834 | -0.116 | 2 | 0.872 |
TSSK2 |
0.834 | -0.020 | -5 | 0.804 |
PERK |
0.834 | 0.063 | -2 | 0.824 |
RIPK3 |
0.833 | -0.136 | 3 | 0.718 |
IRE1 |
0.833 | -0.032 | 1 | 0.739 |
FAM20C |
0.832 | 0.072 | 2 | 0.583 |
PAK1 |
0.832 | 0.032 | -2 | 0.740 |
RSK3 |
0.832 | -0.004 | -3 | 0.716 |
TSSK1 |
0.832 | 0.008 | -3 | 0.830 |
TLK1 |
0.832 | 0.051 | -2 | 0.841 |
LATS1 |
0.831 | 0.022 | -3 | 0.824 |
P90RSK |
0.831 | -0.028 | -3 | 0.720 |
CDK1 |
0.831 | 0.038 | 1 | 0.543 |
CDK8 |
0.831 | -0.018 | 1 | 0.576 |
IRE2 |
0.831 | 0.007 | 2 | 0.808 |
CAMK2B |
0.831 | 0.038 | 2 | 0.809 |
MAPKAPK2 |
0.831 | 0.026 | -3 | 0.693 |
MARK4 |
0.830 | -0.089 | 4 | 0.857 |
ULK1 |
0.830 | -0.145 | -3 | 0.756 |
CDK5 |
0.830 | 0.036 | 1 | 0.610 |
HRI |
0.830 | 0.005 | -2 | 0.828 |
PLK3 |
0.830 | 0.042 | 2 | 0.809 |
MAPKAPK3 |
0.829 | -0.036 | -3 | 0.721 |
VRK2 |
0.829 | -0.213 | 1 | 0.779 |
PKACG |
0.829 | 0.002 | -2 | 0.703 |
CAMK2D |
0.829 | -0.076 | -3 | 0.780 |
GRK2 |
0.829 | -0.009 | -2 | 0.702 |
LATS2 |
0.829 | -0.022 | -5 | 0.696 |
WNK3 |
0.829 | -0.219 | 1 | 0.707 |
AMPKA2 |
0.828 | -0.020 | -3 | 0.782 |
AURA |
0.828 | 0.079 | -2 | 0.641 |
JNK3 |
0.828 | 0.011 | 1 | 0.562 |
SRPK3 |
0.828 | -0.001 | -3 | 0.675 |
CLK4 |
0.828 | 0.045 | -3 | 0.721 |
MEK1 |
0.828 | -0.179 | 2 | 0.868 |
BRAF |
0.827 | -0.010 | -4 | 0.819 |
PKCB |
0.827 | 0.032 | 2 | 0.805 |
PKCA |
0.827 | 0.033 | 2 | 0.805 |
AURB |
0.827 | 0.058 | -2 | 0.652 |
YSK4 |
0.827 | -0.085 | 1 | 0.656 |
CAMK2A |
0.827 | 0.021 | 2 | 0.834 |
RSK4 |
0.827 | 0.033 | -3 | 0.710 |
PINK1 |
0.827 | -0.040 | 1 | 0.774 |
PRKD3 |
0.827 | -0.002 | -3 | 0.693 |
P38A |
0.827 | 0.016 | 1 | 0.653 |
PAK3 |
0.826 | -0.024 | -2 | 0.733 |
MEKK2 |
0.826 | -0.001 | 2 | 0.864 |
P38B |
0.826 | 0.031 | 1 | 0.592 |
PKACB |
0.826 | 0.074 | -2 | 0.665 |
DYRK2 |
0.826 | -0.015 | 1 | 0.627 |
SRPK2 |
0.825 | 0.014 | -3 | 0.625 |
JNK2 |
0.825 | 0.011 | 1 | 0.522 |
PIM2 |
0.825 | 0.038 | -3 | 0.695 |
CLK1 |
0.825 | 0.055 | -3 | 0.703 |
MNK2 |
0.825 | 0.022 | -2 | 0.737 |
MASTL |
0.824 | -0.348 | -2 | 0.721 |
P38G |
0.824 | 0.014 | 1 | 0.459 |
HIPK2 |
0.824 | 0.031 | 1 | 0.541 |
GAK |
0.824 | 0.105 | 1 | 0.801 |
TAO3 |
0.824 | 0.049 | 1 | 0.676 |
HIPK1 |
0.824 | 0.013 | 1 | 0.644 |
CHAK1 |
0.824 | -0.100 | 2 | 0.851 |
RIPK1 |
0.824 | -0.250 | 1 | 0.714 |
CAMK4 |
0.824 | -0.095 | -3 | 0.781 |
PKCG |
0.824 | -0.002 | 2 | 0.813 |
CLK2 |
0.823 | 0.091 | -3 | 0.722 |
PKCZ |
0.823 | -0.004 | 2 | 0.854 |
ERK1 |
0.823 | 0.010 | 1 | 0.568 |
NEK5 |
0.823 | -0.027 | 1 | 0.747 |
CK2A2 |
0.822 | 0.162 | 1 | 0.658 |
MYLK4 |
0.822 | -0.013 | -2 | 0.746 |
BCKDK |
0.822 | -0.223 | -1 | 0.770 |
NEK2 |
0.822 | -0.094 | 2 | 0.882 |
PRKX |
0.822 | 0.103 | -3 | 0.652 |
PKG2 |
0.822 | 0.039 | -2 | 0.658 |
PRP4 |
0.821 | -0.012 | -3 | 0.697 |
MEKK3 |
0.821 | -0.106 | 1 | 0.687 |
PKCH |
0.821 | -0.012 | 2 | 0.799 |
MPSK1 |
0.821 | 0.049 | 1 | 0.772 |
MELK |
0.821 | -0.052 | -3 | 0.759 |
CDK19 |
0.821 | -0.029 | 1 | 0.539 |
AKT2 |
0.821 | 0.023 | -3 | 0.641 |
PAK2 |
0.821 | -0.043 | -2 | 0.722 |
CDK7 |
0.821 | -0.051 | 1 | 0.589 |
MSK2 |
0.821 | -0.042 | -3 | 0.678 |
MEKK1 |
0.820 | -0.105 | 1 | 0.708 |
CHK1 |
0.820 | -0.029 | -3 | 0.791 |
NUAK1 |
0.820 | -0.052 | -3 | 0.757 |
MNK1 |
0.820 | 0.010 | -2 | 0.746 |
PAK6 |
0.820 | 0.087 | -2 | 0.669 |
CDK18 |
0.819 | 0.002 | 1 | 0.527 |
GRK3 |
0.819 | 0.025 | -2 | 0.673 |
DCAMKL1 |
0.819 | -0.011 | -3 | 0.754 |
MEK5 |
0.819 | -0.229 | 2 | 0.869 |
PHKG1 |
0.819 | -0.043 | -3 | 0.788 |
SGK3 |
0.818 | -0.001 | -3 | 0.699 |
ZAK |
0.818 | -0.115 | 1 | 0.667 |
NEK8 |
0.817 | -0.035 | 2 | 0.874 |
P38D |
0.817 | 0.024 | 1 | 0.493 |
EEF2K |
0.817 | 0.061 | 3 | 0.817 |
CDK13 |
0.817 | -0.052 | 1 | 0.559 |
NIM1 |
0.817 | -0.154 | 3 | 0.760 |
ERK2 |
0.817 | -0.040 | 1 | 0.593 |
PASK |
0.816 | -0.042 | -3 | 0.807 |
MST3 |
0.816 | -0.033 | 2 | 0.882 |
CDK2 |
0.816 | -0.013 | 1 | 0.607 |
PLK2 |
0.816 | 0.110 | -3 | 0.811 |
CK1E |
0.816 | -0.013 | -3 | 0.543 |
SMMLCK |
0.815 | -0.046 | -3 | 0.762 |
CDK3 |
0.815 | 0.047 | 1 | 0.491 |
MSK1 |
0.815 | -0.014 | -3 | 0.684 |
IRAK4 |
0.815 | -0.086 | 1 | 0.736 |
CAMK1G |
0.814 | -0.053 | -3 | 0.715 |
QSK |
0.814 | -0.077 | 4 | 0.832 |
PLK4 |
0.814 | -0.098 | 2 | 0.699 |
SIK |
0.814 | -0.059 | -3 | 0.722 |
CAMKK1 |
0.814 | -0.106 | -2 | 0.686 |
CDK17 |
0.813 | -0.023 | 1 | 0.465 |
ERK7 |
0.813 | 0.112 | 2 | 0.652 |
DAPK3 |
0.813 | 0.021 | -3 | 0.764 |
WNK4 |
0.813 | -0.145 | -2 | 0.764 |
QIK |
0.812 | -0.169 | -3 | 0.773 |
BRSK1 |
0.812 | -0.068 | -3 | 0.748 |
SMG1 |
0.812 | -0.151 | 1 | 0.691 |
HIPK3 |
0.812 | -0.030 | 1 | 0.627 |
LKB1 |
0.812 | -0.074 | -3 | 0.766 |
CK1D |
0.812 | -0.006 | -3 | 0.492 |
DNAPK |
0.812 | -0.089 | 1 | 0.567 |
DRAK1 |
0.811 | -0.132 | 1 | 0.623 |
DCAMKL2 |
0.811 | -0.043 | -3 | 0.777 |
PKACA |
0.811 | 0.050 | -2 | 0.628 |
DYRK1A |
0.811 | -0.044 | 1 | 0.639 |
TAO2 |
0.811 | -0.078 | 2 | 0.897 |
AKT1 |
0.810 | 0.024 | -3 | 0.658 |
TTK |
0.810 | 0.138 | -2 | 0.821 |
MARK2 |
0.810 | -0.089 | 4 | 0.761 |
MARK3 |
0.809 | -0.077 | 4 | 0.792 |
TNIK |
0.809 | 0.003 | 3 | 0.847 |
GSK3A |
0.809 | -0.002 | 4 | 0.416 |
DYRK1B |
0.809 | -0.022 | 1 | 0.566 |
CDK12 |
0.809 | -0.057 | 1 | 0.527 |
SSTK |
0.808 | -0.047 | 4 | 0.833 |
CAMK1D |
0.808 | -0.018 | -3 | 0.650 |
CK1A2 |
0.808 | -0.015 | -3 | 0.490 |
MAK |
0.808 | 0.065 | -2 | 0.676 |
JNK1 |
0.808 | -0.008 | 1 | 0.508 |
CK2A1 |
0.808 | 0.114 | 1 | 0.630 |
PKCT |
0.807 | -0.032 | 2 | 0.806 |
DYRK3 |
0.807 | -0.012 | 1 | 0.645 |
MST2 |
0.807 | -0.067 | 1 | 0.694 |
TAK1 |
0.807 | -0.070 | 1 | 0.716 |
BRSK2 |
0.807 | -0.118 | -3 | 0.767 |
DYRK4 |
0.806 | -0.025 | 1 | 0.549 |
GCK |
0.806 | -0.077 | 1 | 0.676 |
CAMKK2 |
0.806 | -0.131 | -2 | 0.680 |
CDK16 |
0.806 | -0.006 | 1 | 0.487 |
P70S6K |
0.806 | -0.043 | -3 | 0.642 |
PDK1 |
0.805 | -0.148 | 1 | 0.677 |
ROCK2 |
0.805 | 0.041 | -3 | 0.739 |
MAPKAPK5 |
0.805 | -0.146 | -3 | 0.634 |
CDK9 |
0.805 | -0.085 | 1 | 0.562 |
BUB1 |
0.804 | 0.063 | -5 | 0.764 |
MINK |
0.804 | -0.080 | 1 | 0.687 |
NEK4 |
0.804 | -0.147 | 1 | 0.695 |
MEKK6 |
0.804 | -0.109 | 1 | 0.713 |
CDK14 |
0.804 | -0.040 | 1 | 0.558 |
CK1G1 |
0.804 | -0.035 | -3 | 0.557 |
HGK |
0.804 | -0.079 | 3 | 0.842 |
MAP3K15 |
0.804 | -0.136 | 1 | 0.646 |
OSR1 |
0.804 | 0.064 | 2 | 0.852 |
VRK1 |
0.804 | -0.127 | 2 | 0.864 |
TTBK1 |
0.804 | -0.142 | 2 | 0.729 |
NEK11 |
0.803 | -0.242 | 1 | 0.665 |
LRRK2 |
0.803 | -0.145 | 2 | 0.903 |
PBK |
0.803 | 0.062 | 1 | 0.759 |
GSK3B |
0.803 | -0.053 | 4 | 0.405 |
SNRK |
0.803 | -0.224 | 2 | 0.726 |
MRCKB |
0.803 | 0.025 | -3 | 0.693 |
PKCE |
0.803 | 0.010 | 2 | 0.803 |
DMPK1 |
0.802 | 0.070 | -3 | 0.732 |
MARK1 |
0.802 | -0.132 | 4 | 0.812 |
ALPHAK3 |
0.802 | 0.138 | -1 | 0.882 |
DAPK1 |
0.801 | -0.020 | -3 | 0.737 |
PKCI |
0.801 | -0.034 | 2 | 0.824 |
NEK1 |
0.801 | -0.116 | 1 | 0.713 |
MOK |
0.800 | 0.029 | 1 | 0.717 |
PHKG2 |
0.800 | -0.069 | -3 | 0.762 |
MST1 |
0.799 | -0.104 | 1 | 0.678 |
CDK10 |
0.798 | -0.025 | 1 | 0.547 |
IRAK1 |
0.798 | -0.266 | -1 | 0.727 |
LOK |
0.798 | -0.088 | -2 | 0.678 |
PAK5 |
0.797 | 0.012 | -2 | 0.607 |
AKT3 |
0.797 | 0.018 | -3 | 0.573 |
CAMK1A |
0.797 | -0.015 | -3 | 0.620 |
BIKE |
0.797 | 0.092 | 1 | 0.720 |
CHK2 |
0.797 | -0.040 | -3 | 0.585 |
SGK1 |
0.796 | -0.001 | -3 | 0.555 |
KHS1 |
0.796 | -0.069 | 1 | 0.667 |
MRCKA |
0.796 | -0.014 | -3 | 0.714 |
HPK1 |
0.795 | -0.131 | 1 | 0.658 |
PAK4 |
0.795 | 0.027 | -2 | 0.624 |
KHS2 |
0.794 | -0.045 | 1 | 0.670 |
HASPIN |
0.794 | 0.013 | -1 | 0.687 |
CDK6 |
0.793 | -0.036 | 1 | 0.540 |
SLK |
0.793 | -0.098 | -2 | 0.619 |
PDHK3_TYR |
0.793 | 0.143 | 4 | 0.899 |
YSK1 |
0.792 | -0.106 | 2 | 0.876 |
ROCK1 |
0.790 | 0.015 | -3 | 0.707 |
MYO3B |
0.789 | -0.022 | 2 | 0.880 |
STK33 |
0.789 | -0.167 | 2 | 0.711 |
CDK4 |
0.789 | -0.059 | 1 | 0.518 |
MEK2 |
0.788 | -0.287 | 2 | 0.851 |
SBK |
0.788 | -0.025 | -3 | 0.528 |
PKN1 |
0.787 | -0.067 | -3 | 0.657 |
MAP2K6_TYR |
0.786 | 0.094 | -1 | 0.880 |
MAP2K4_TYR |
0.786 | 0.093 | -1 | 0.887 |
CRIK |
0.786 | -0.004 | -3 | 0.652 |
MYO3A |
0.786 | -0.049 | 1 | 0.680 |
ABL2 |
0.784 | 0.247 | -1 | 0.870 |
PDHK4_TYR |
0.784 | 0.038 | 2 | 0.886 |
AAK1 |
0.784 | 0.132 | 1 | 0.643 |
TESK1_TYR |
0.784 | -0.050 | 3 | 0.866 |
PDHK1_TYR |
0.783 | 0.048 | -1 | 0.890 |
ASK1 |
0.783 | -0.179 | 1 | 0.634 |
BMPR2_TYR |
0.783 | 0.038 | -1 | 0.873 |
TXK |
0.782 | 0.183 | 1 | 0.759 |
PKMYT1_TYR |
0.782 | -0.035 | 3 | 0.831 |
EPHB4 |
0.781 | 0.125 | -1 | 0.863 |
NEK3 |
0.780 | -0.200 | 1 | 0.662 |
MAP2K7_TYR |
0.780 | -0.128 | 2 | 0.896 |
EPHA6 |
0.780 | 0.082 | -1 | 0.871 |
ABL1 |
0.779 | 0.210 | -1 | 0.858 |
RIPK2 |
0.778 | -0.324 | 1 | 0.621 |
PKG1 |
0.778 | -0.019 | -2 | 0.586 |
LIMK2_TYR |
0.777 | -0.002 | -3 | 0.847 |
PINK1_TYR |
0.776 | -0.127 | 1 | 0.744 |
FER |
0.776 | 0.096 | 1 | 0.793 |
TAO1 |
0.776 | -0.123 | 1 | 0.605 |
STLK3 |
0.776 | -0.140 | 1 | 0.631 |
FGR |
0.775 | 0.082 | 1 | 0.804 |
BLK |
0.775 | 0.189 | -1 | 0.807 |
LIMK1_TYR |
0.775 | -0.076 | 2 | 0.901 |
RET |
0.775 | -0.049 | 1 | 0.696 |
YANK3 |
0.774 | -0.054 | 2 | 0.478 |
CK1A |
0.774 | -0.022 | -3 | 0.417 |
LCK |
0.774 | 0.142 | -1 | 0.810 |
YES1 |
0.773 | 0.077 | -1 | 0.822 |
ROS1 |
0.773 | -0.004 | 3 | 0.760 |
BMX |
0.772 | 0.168 | -1 | 0.818 |
TYRO3 |
0.772 | -0.028 | 3 | 0.787 |
INSRR |
0.771 | 0.040 | 3 | 0.734 |
EPHB2 |
0.771 | 0.099 | -1 | 0.848 |
MST1R |
0.771 | -0.078 | 3 | 0.786 |
CSF1R |
0.771 | -0.022 | 3 | 0.769 |
ITK |
0.770 | 0.063 | -1 | 0.789 |
EPHA4 |
0.770 | 0.032 | 2 | 0.799 |
TYK2 |
0.769 | -0.119 | 1 | 0.702 |
MET |
0.769 | 0.060 | 3 | 0.762 |
JAK2 |
0.768 | -0.090 | 1 | 0.695 |
KIT |
0.768 | 0.010 | 3 | 0.773 |
EPHB1 |
0.767 | 0.032 | 1 | 0.759 |
HCK |
0.767 | 0.025 | -1 | 0.803 |
EPHB3 |
0.767 | 0.036 | -1 | 0.834 |
TNK2 |
0.766 | 0.037 | 3 | 0.734 |
SRMS |
0.766 | 0.012 | 1 | 0.765 |
FYN |
0.766 | 0.108 | -1 | 0.794 |
JAK3 |
0.766 | -0.063 | 1 | 0.670 |
TNNI3K_TYR |
0.766 | 0.044 | 1 | 0.769 |
KDR |
0.765 | -0.013 | 3 | 0.734 |
LTK |
0.765 | 0.081 | 3 | 0.720 |
TEC |
0.765 | 0.050 | -1 | 0.769 |
PDGFRB |
0.764 | -0.066 | 3 | 0.785 |
DDR1 |
0.764 | -0.137 | 4 | 0.832 |
FLT3 |
0.764 | -0.040 | 3 | 0.778 |
MERTK |
0.763 | 0.025 | 3 | 0.757 |
FGFR2 |
0.762 | -0.070 | 3 | 0.769 |
MATK |
0.762 | 0.100 | -1 | 0.867 |
ALK |
0.762 | 0.005 | 3 | 0.699 |
WEE1_TYR |
0.760 | 0.023 | -1 | 0.836 |
FGFR1 |
0.759 | -0.076 | 3 | 0.747 |
CK1G3 |
0.759 | -0.038 | -3 | 0.375 |
PTK6 |
0.758 | -0.033 | -1 | 0.785 |
JAK1 |
0.758 | -0.038 | 1 | 0.622 |
EPHA7 |
0.758 | -0.004 | 2 | 0.815 |
NTRK1 |
0.758 | -0.030 | -1 | 0.879 |
INSR |
0.757 | 0.001 | 3 | 0.712 |
EPHA3 |
0.757 | -0.029 | 2 | 0.790 |
FLT1 |
0.757 | -0.050 | -1 | 0.853 |
LYN |
0.756 | 0.015 | 3 | 0.696 |
NTRK3 |
0.756 | 0.064 | -1 | 0.869 |
TNK1 |
0.756 | -0.077 | 3 | 0.770 |
PTK2B |
0.756 | 0.031 | -1 | 0.811 |
AXL |
0.755 | -0.095 | 3 | 0.756 |
EGFR |
0.755 | 0.028 | 1 | 0.556 |
SRC |
0.755 | 0.044 | -1 | 0.803 |
NTRK2 |
0.754 | -0.040 | 3 | 0.729 |
ERBB2 |
0.754 | -0.095 | 1 | 0.638 |
TEK |
0.754 | -0.145 | 3 | 0.731 |
BTK |
0.754 | -0.114 | -1 | 0.744 |
EPHA5 |
0.753 | 0.017 | 2 | 0.784 |
FGFR3 |
0.753 | -0.070 | 3 | 0.744 |
SYK |
0.752 | 0.056 | -1 | 0.810 |
FLT4 |
0.752 | -0.092 | 3 | 0.732 |
NEK10_TYR |
0.752 | -0.161 | 1 | 0.566 |
PDGFRA |
0.751 | -0.210 | 3 | 0.783 |
EPHA8 |
0.751 | -0.003 | -1 | 0.823 |
FGFR4 |
0.751 | 0.053 | -1 | 0.875 |
FRK |
0.750 | -0.072 | -1 | 0.815 |
CSK |
0.750 | -0.015 | 2 | 0.818 |
PTK2 |
0.747 | 0.025 | -1 | 0.758 |
EPHA1 |
0.746 | -0.113 | 3 | 0.746 |
CK1G2 |
0.746 | -0.025 | -3 | 0.473 |
IGF1R |
0.745 | 0.016 | 3 | 0.655 |
YANK2 |
0.744 | -0.084 | 2 | 0.493 |
DDR2 |
0.743 | -0.060 | 3 | 0.707 |
EPHA2 |
0.742 | 0.002 | -1 | 0.818 |
MUSK |
0.738 | -0.060 | 1 | 0.558 |
ERBB4 |
0.738 | -0.044 | 1 | 0.590 |
ZAP70 |
0.737 | 0.072 | -1 | 0.814 |
FES |
0.730 | -0.003 | -1 | 0.815 |