Motif 764 (n=241)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NI28 | ARHGAP42 | S383 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| A6NMZ7 | COL6A6 | S816 | ochoa | Collagen alpha-6(VI) chain | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| A8MT19 | RHPN2P1 | S496 | ochoa | Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) | None |
| E7ETH6 | ZNF587B | S205 | ochoa | Zinc finger protein 587B | May be involved in transcriptional regulation. {ECO:0000305}. |
| O00165 | HAX1 | S210 | psp | HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1) | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16857965, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:18319618, ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:26997484, ECO:0000269|PubMed:9058808}. |
| O14981 | BTAF1 | S257 | ochoa | TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) | Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. |
| O15013 | ARHGEF10 | S1258 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| O15055 | PER2 | S480 | psp | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15061 | SYNM | S628 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15062 | ZBTB5 | S516 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O15357 | INPPL1 | S980 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O43164 | PJA2 | S241 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43248 | HOXC11 | S88 | ochoa | Homeobox protein Hox-C11 (Homeobox protein Hox-3H) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene. |
| O43504 | LAMTOR5 | S26 | ochoa|psp | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:29158492, PubMed:30181260). When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (PubMed:12773388). {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}. |
| O43683 | BUB1 | S176 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43707 | ACTN4 | S656 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60237 | PPP1R12B | S395 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60292 | SIPA1L3 | S217 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60701 | UGDH | S216 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O75030 | MITF | S216 | ochoa | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}. |
| O75037 | KIF21B | S510 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75131 | CPNE3 | S197 | ochoa | Copine-3 (Copine III) | Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). {ECO:0000269|PubMed:20010870}. |
| O75363 | BCAS1 | S451 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75376 | NCOR1 | S1322 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75391 | SPAG7 | S63 | ochoa | Sperm-associated antigen 7 | None |
| O75509 | TNFRSF21 | S565 | ochoa | Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358) | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed:34012073). {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:22761420, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:9714541}. |
| O75533 | SF3B1 | S190 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75886 | STAM2 | S372 | ochoa | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
| O94782 | USP1 | S727 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94915 | FRYL | S218 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94967 | WDR47 | S183 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95071 | UBR5 | S2080 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95340 | PAPSS2 | S26 | ochoa | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). Plays indirectly an important role in skeletogenesis during postnatal growth (PubMed:9771708). {ECO:0000269|PubMed:11773860, ECO:0000269|PubMed:19474428, ECO:0000269|PubMed:23824674, ECO:0000269|PubMed:25594860, ECO:0000269|PubMed:9771708}. |
| O95425 | SVIL | S1314 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95490 | ADGRL2 | S1276 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| O95573 | ACSL3 | S62 | ochoa | Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250|UniProtKB:Q63151, ECO:0000269|PubMed:18003621, ECO:0000269|PubMed:22633490}. |
| O95831 | AIFM1 | S375 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P01275 | GCG | S150 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| P04792 | HSPB1 | S176 | ochoa|psp | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P05165 | PCCA | S252 | ochoa | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:8434582). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:10101253, PubMed:6765947, PubMed:8434582). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P0DTA4, ECO:0000250|UniProtKB:Q5LUF3, ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:6765947, ECO:0000269|PubMed:8434582}. |
| P06744 | GPI | S185 | psp | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
| P07451 | CA3 | S48 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P07954 | FH | S75 | psp | Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2) | Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). {ECO:0000269|PubMed:30761759, ECO:0000305}.; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. {ECO:0000250|UniProtKB:P10173}.; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645). {ECO:0000250|UniProtKB:P97807, ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}. |
| P08962 | CD63 | S113 | ochoa | CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}. |
| P0DMV8 | HSPA1A | S544 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S544 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P10155 | RO60 | S19 | ochoa | RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) | RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853). Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). May play roles in cilia formation and/or maintenance (By similarity). {ECO:0000250|UniProtKB:O08848, ECO:0000269|PubMed:18056422, ECO:0000269|PubMed:26382853}. |
| P10275 | AR | S220 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P11217 | PYGM | S747 | ochoa | Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) | Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:8316268}. |
| P12757 | SKIL | S75 | ochoa | Ski-like protein (Ski-related oncogene) (Ski-related protein) | May have regulatory role in cell division or differentiation in response to extracellular signals. |
| P16070 | CD44 | S718 | ochoa | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P16144 | ITGB4 | S1002 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17540 | CKMT2 | S319 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P17948 | FLT1 | S1207 | ochoa | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| P18206 | VCL | S443 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19367 | HK1 | S337 | ochoa | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P22626 | HNRNPA2B1 | S58 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23771 | GATA3 | S198 | ochoa | Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P23772, ECO:0000269|PubMed:23824597}. |
| P25705 | ATP5F1A | S254 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P27448 | MARK3 | S724 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P27816 | MAP4 | S656 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | S1073 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28347 | TEAD1 | S61 | ochoa | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| P31629 | HIVEP2 | S619 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P32780 | GTF2H1 | S339 | ochoa | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:9852112}. |
| P34931 | HSPA1L | S546 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35236 | PTPN7 | S246 | psp | Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269|PubMed:10206983, ECO:0000269|PubMed:10559944, ECO:0000269|PubMed:10702794, ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918, ECO:0000269|PubMed:9624114}. |
| P35503 | UGT1A3 | S43 | psp | UDP-glucuronosyltransferase 1A3 (UGT1A3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-3) (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A isoform 3) | [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23288867, PubMed:23756265, PubMed:24641623, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515). {ECO:0000269|PubMed:15472229, ECO:0000269|PubMed:18674515, ECO:0000269|PubMed:18719240, ECO:0000269|PubMed:21422672, ECO:0000269|PubMed:23288867, ECO:0000269|PubMed:23756265, ECO:0000269|PubMed:24641623}.; FUNCTION: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:20610558}. |
| P38398 | BRCA1 | S454 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41238 | APOBEC1 | S47 | psp | C->U-editing enzyme APOBEC-1 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic subunit 1) (APO1) (APOBEC-1) (Apolipoprotein B mRNA-editing enzyme 1) (EC 3.5.4.36) (HEPR) (mRNA(cytosine(6666)) deaminase 1) | Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). {ECO:0000250|UniProtKB:P51908, ECO:0000269|PubMed:11727199, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:30844405}. |
| P43243 | MATR3 | S509 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P43686 | PSMC4 | S19 | ochoa | 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}. |
| P46013 | MKI67 | S2814 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48047 | ATP5PO | S166 | ochoa | ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP synthase subunit O) (Oligomycin sensitivity conferral protein) (OSCP) | Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13621, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P49959 | MRE11 | S531 | psp | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P50502 | ST13 | S346 | psp | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P50570 | DNM2 | S644 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
| P51003 | PAPOLA | S718 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51114 | FXR1 | S587 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P51608 | MECP2 | S274 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P51610 | HCFC1 | S1070 | psp | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P51828 | ADCY7 | S505 | ochoa | Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) | Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:18541530, PubMed:23229509). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23229509, PubMed:23842570). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). {ECO:0000250|UniProtKB:P51829, ECO:0000269|PubMed:18541530, ECO:0000269|PubMed:23229509, ECO:0000269|PubMed:23842570, ECO:0000305|PubMed:18541530, ECO:0000305|PubMed:23229509}. |
| P52569 | SLC7A2 | S464 | ochoa | Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) | Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}. |
| P52597 | HNRNPF | S100 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P53367 | ARFIP1 | S36 | ochoa | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
| P55072 | VCP | S705 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P60983 | GMFB | S72 | psp | Glia maturation factor beta (GMF-beta) | This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. |
| P61978 | HNRNPK | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P63010 | AP2B1 | S258 | psp | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P78527 | PRKDC | S2624 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78545 | ELF3 | S68 | psp | ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}. |
| P98088 | MUC5AC | S988 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| Q00987 | MDM2 | S425 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q02383 | SEMG2 | S490 | ochoa | Semenogelin-2 (Semenogelin II) (SGII) | Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. |
| Q02952 | AKAP12 | S472 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05682 | CALD1 | S73 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q07817 | BCL2L1 | S145 | psp | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis. |
| Q08050 | FOXM1 | S251 | psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q09472 | EP300 | S19 | psp | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q09666 | AHNAK | S337 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12968 | NFATC3 | S372 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q12986 | NFX1 | S978 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13308 | PTK7 | S337 | ochoa | Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}. |
| Q13813 | SPTAN1 | S2141 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14247 | CTTN | S156 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14624 | ITIH4 | S622 | ochoa | Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269|PubMed:19263524}. |
| Q14980 | NUMA1 | S1601 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14BN4 | SLMAP | S402 | ochoa | Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) | Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}. |
| Q15003 | NCAPH | S256 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15149 | PLEC | S2749 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15262 | PTPRK | S809 | ochoa | Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}. |
| Q15398 | DLGAP5 | S721 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15459 | SF3A1 | S508 | ochoa | Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006}. |
| Q15561 | TEAD4 | S69 | ochoa | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q15562 | TEAD2 | S71 | ochoa | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q15637 | SF1 | S272 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
| Q562F6 | SGO2 | S509 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5BKZ1 | ZNF326 | S91 | ochoa | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q5QJE6 | DNTTIP2 | S483 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5VST9 | OBSCN | S6942 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT52 | RPRD2 | S744 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q66K14 | TBC1D9B | S463 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q68D20 | PMS2CL | S161 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
| Q6F5E8 | CARMIL2 | S1246 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IBW4 | NCAPH2 | S328 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6IQ55 | TTBK2 | S817 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6L8Q7 | PDE12 | S442 | ochoa | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
| Q6NUJ5 | PWWP2B | S476 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6P3S1 | DENND1B | S580 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6P4F7 | ARHGAP11A | S604 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6ZVL6 | KIAA1549L | S1593 | ochoa | UPF0606 protein KIAA1549L | None |
| Q70CQ2 | USP34 | S718 | psp | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q70EL1 | USP54 | S1531 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7KZI7 | MARK2 | S722 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7KZI7 | MARK2 | S759 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z2T5 | TRMT1L | S243 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q7Z5K2 | WAPL | S130 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z699 | SPRED1 | S176 | ochoa | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}. |
| Q7Z7L1 | SLFN11 | S219 | psp | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q8IUC4 | RHPN2 | S599 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8IUW5 | RELL1 | S109 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8IVF2 | AHNAK2 | S5128 | ochoa | Protein AHNAK2 | None |
| Q8IVF5 | TIAM2 | S337 | ochoa | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
| Q8IX01 | SUGP2 | S824 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IXI1 | RHOT2 | S156 | psp | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8IXI2 | RHOT1 | S156 | psp | Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788). Can hydrolyze GTP, ATP and UTP (PubMed:30513825). {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27716788, ECO:0000269|PubMed:30513825}. |
| Q8IYA6 | CKAP2L | S110 | ochoa | Cytoskeleton-associated protein 2-like (Radial fiber and mitotic spindle protein) (Radmis) | Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. {ECO:0000269|PubMed:25439729}. |
| Q8IZH2 | XRN1 | S1279 | ochoa | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. |
| Q8IZT6 | ASPM | S2806 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N1W1 | ARHGEF28 | S590 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N371 | KDM8 | S361 | psp | Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8) | Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (PubMed:28847961, PubMed:28982940, PubMed:29459673, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:28982940, PubMed:29459673). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionally, acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822). {ECO:0000250|UniProtKB:Q9CXT6, ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:24740926, ECO:0000269|PubMed:24981860, ECO:0000269|PubMed:28455245, ECO:0000269|PubMed:28847961, ECO:0000269|PubMed:28982940, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0000269|PubMed:30500822}. |
| Q8N3C7 | CLIP4 | S432 | ochoa | CAP-Gly domain-containing linker protein 4 (Restin-like protein 2) | None |
| Q8N3J3 | HROB | S208 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8NFC6 | BOD1L1 | S983 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFW8 | CMAS | S395 | ochoa | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). |
| Q8TB52 | FBXO30 | S192 | ochoa | F-box only protein 30 | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. {ECO:0000250}. |
| Q8TD08 | MAPK15 | S192 | psp | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q8TED9 | AFAP1L1 | S361 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Q8TEQ0 | SNX29 | S642 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TEW0 | PARD3 | S837 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WU90 | ZC3H15 | S360 | ochoa | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q8WVD3 | RNF138 | S127 | ochoa | E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) | E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. |
| Q8WVV4 | POF1B | S539 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WWI1 | LMO7 | S1129 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WX93 | PALLD | S53 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXW3 | PIBF1 | S700 | ochoa | Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) | Plays a role in ciliogenesis. {ECO:0000269|PubMed:26167768}.; FUNCTION: [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.; FUNCTION: [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect (PubMed:12516630, PubMed:14634107, PubMed:3863495). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441). {ECO:0000269|PubMed:12516630, ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:16393965, ECO:0000269|PubMed:25218441, ECO:0000269|PubMed:3863495, ECO:0000305|PubMed:11407300}. |
| Q92499 | DDX1 | S671 | psp | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92547 | TOPBP1 | S1236 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92766 | RREB1 | S1238 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92786 | PROX1 | S453 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92994 | BRF1 | S410 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q96C19 | EFHD2 | S183 | ochoa|psp | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| Q96D71 | REPS1 | S104 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96DN5 | TBC1D31 | S1015 | ochoa | TBC1 domain family member 31 (WD repeat-containing protein 67) | Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation. {ECO:0000269|PubMed:33934390}. |
| Q96GD3 | SCMH1 | S507 | ochoa | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. {ECO:0000250}. |
| Q96GE4 | CEP95 | S544 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96GX5 | MASTL | S551 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96HE7 | ERO1A | S145 | ochoa|psp | ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) | Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (PubMed:29858230). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870, ECO:0000269|PubMed:29858230}. |
| Q96HH9 | GRAMD2B | S71 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96HI0 | SENP5 | S416 | ochoa | Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. |
| Q96JQ0 | DCHS1 | S3059 | ochoa | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}. |
| Q96M27 | PRRC1 | S254 | ochoa | Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1) | May act as a regulator of the protein kinase A (PKA) activity during embryonic development. {ECO:0000250|UniProtKB:Q5XJA3}. |
| Q96RE7 | NACC1 | S188 | ochoa | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}. |
| Q96RG2 | PASK | S533 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96T23 | RSF1 | S1325 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99567 | NUP88 | S540 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99570 | PIK3R4 | S926 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99594 | TEAD3 | S61 | ochoa | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q99808 | SLC29A1 | S281 | psp | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
| Q9BSJ5 | MTNAP1 | S231 | ochoa | Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80) | Critical regulator of mitochondrial DNA (mtDNA) abundance (PubMed:37676315). Binds dsDNA throughout the mitochondrial genome without sequence specificity and controls mtDNA copy number by promoting its replication (PubMed:37676315). Also plays important roles in mitochondrial metabolism and cell proliferation (PubMed:37676315). {ECO:0000269|PubMed:37676315}. |
| Q9BVW5 | TIPIN | S220 | ochoa | TIMELESS-interacting protein | Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}. |
| Q9BW92 | TARS2 | S389 | ochoa | Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. {ECO:0000269|PubMed:26811336}. |
| Q9C073 | FAM117A | S355 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9H201 | EPN3 | S505 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H2H9 | SLC38A1 | S25 | ochoa | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}. |
| Q9H2Y7 | ZNF106 | S556 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H425 | C1orf198 | S134 | ochoa | Uncharacterized protein C1orf198 | None |
| Q9H694 | BICC1 | S766 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9H981 | ACTR8 | S468 | ochoa | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. |
| Q9H9B1 | EHMT1 | S1048 | ochoa | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. |
| Q9HCE1 | MOV10 | S815 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9NQW6 | ANLN | S561 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR48 | ASH1L | S623 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NUQ3 | TXLNG | S58 | ochoa | Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) | May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. {ECO:0000269|PubMed:15911876, ECO:0000269|PubMed:18068885}. |
| Q9NXF1 | TEX10 | S287 | ochoa | Testis-expressed protein 10 | Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). {ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q9NXL9 | MCM9 | S663 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9P0K8 | FOXJ2 | S439 | ochoa | Forkhead box protein J2 (Fork head homologous X) | [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}. |
| Q9UBV2 | SEL1L | S41 | ochoa | Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207, PubMed:37943610, PubMed:37943617). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:29997207, ECO:0000269|PubMed:37943610, ECO:0000269|PubMed:37943617}. |
| Q9UHI6 | DDX20 | S560 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UID6 | ZNF639 | S19 | ochoa | Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1) | Binds DNA and may function as a transcriptional repressor. {ECO:0000269|PubMed:16182284}. |
| Q9UJV9 | DDX41 | S302 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9UL54 | TAOK2 | S414 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULH0 | KIDINS220 | S1296 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9UP83 | COG5 | S304 | ochoa | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}. |
| Q9Y2E4 | DIP2C | S218 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y2F5 | ICE1 | S892 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2K6 | USP20 | S854 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y4G8 | RAPGEF2 | S1244 | psp | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y6D5 | ARFGEF2 | S349 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6D9 | MAD1L1 | S22 | ochoa|psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9Y6M5 | SLC30A1 | S197 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| P49588 | AARS1 | S775 | Sugiyama | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| Q8WWI1 | LMO7 | S1182 | Sugiyama | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q9Y2T3 | GDA | S263 | Sugiyama | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}. |
| O14976 | GAK | S399 | Sugiyama | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15111 | CHUK | S369 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P31948 | STIP1 | S45 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P42167 | TMPO | S167 | Sugiyama | Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P36871 | PGM1 | S485 | Sugiyama | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| Q86TB9 | PATL1 | S564 | Sugiyama | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| P35222 | CTNNB1 | S179 | PSP | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P54278 | PMS2 | S547 | Sugiyama | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| O00165 | HAX1 | S162 | Sugiyama | HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1) | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16857965, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:18319618, ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:26997484, ECO:0000269|PubMed:9058808}. |
| Q14164 | IKBKE | S650 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q7Z417 | NUFIP2 | S121 | Sugiyama | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q96S59 | RANBP9 | S613 | Sugiyama | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q8N568 | DCLK2 | S385 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| O15067 | PFAS | S225 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| Q13617 | CUL2 | S230 | Sugiyama | Cullin-2 (CUL-2) | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:11384984, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:38326650). CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme (PubMed:10973499, PubMed:11384984, PubMed:12609982, PubMed:24076655, PubMed:9122164, PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:12609982, PubMed:24076655, PubMed:27565346, PubMed:38326650). The functional specificity of the ECS complex depends on the substrate recognition component (PubMed:10973499, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:9122164, PubMed:38326650). ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (PubMed:10973499, PubMed:9122164). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948). ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). {ECO:0000250|UniProtKB:Q9D4H8, ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:9122164}. |
| P55036 | PSMD4 | S242 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| Q5T5U3 | ARHGAP21 | S131 | PSP | Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.665335e-15 | 14.778 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.662137e-15 | 14.247 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 4.914759e-06 | 5.308 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.791979e-06 | 5.056 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 2.580441e-05 | 4.588 |
| R-HSA-2262752 | Cellular responses to stress | 3.700564e-05 | 4.432 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 9.313145e-05 | 4.031 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 3.631782e-04 | 3.440 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 4.568520e-04 | 3.340 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 6.441958e-04 | 3.191 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 9.295265e-04 | 3.032 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.140855e-03 | 2.943 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 1.845549e-03 | 2.734 |
| R-HSA-5688426 | Deubiquitination | 1.830836e-03 | 2.737 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.568931e-03 | 2.590 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 3.284184e-03 | 2.484 |
| R-HSA-9697154 | Disorders of Nervous System Development | 3.284184e-03 | 2.484 |
| R-HSA-9005895 | Pervasive developmental disorders | 3.284184e-03 | 2.484 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 2.742381e-03 | 2.562 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.952536e-03 | 2.530 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.318986e-03 | 2.479 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 3.884026e-03 | 2.411 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 3.887165e-03 | 2.410 |
| R-HSA-9796292 | Formation of axial mesoderm | 3.887165e-03 | 2.410 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.529596e-03 | 2.452 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.828177e-03 | 2.316 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.292876e-03 | 2.276 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 5.284458e-03 | 2.277 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 5.526558e-03 | 2.258 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 7.433036e-03 | 2.129 |
| R-HSA-9675151 | Disorders of Developmental Biology | 6.948198e-03 | 2.158 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.433036e-03 | 2.129 |
| R-HSA-9764561 | Regulation of CDH1 Function | 7.162837e-03 | 2.145 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.641507e-03 | 2.178 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.641507e-03 | 2.178 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.494116e-03 | 2.125 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 8.889838e-03 | 2.051 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 9.967820e-03 | 2.001 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.062997e-02 | 1.973 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.335111e-02 | 1.874 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 1.463763e-02 | 1.835 |
| R-HSA-8953854 | Metabolism of RNA | 1.429835e-02 | 1.845 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.628837e-02 | 1.788 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.750271e-02 | 1.757 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.750271e-02 | 1.757 |
| R-HSA-9675135 | Diseases of DNA repair | 1.773656e-02 | 1.751 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 1.958829e-02 | 1.708 |
| R-HSA-9766229 | Degradation of CDH1 | 2.112100e-02 | 1.675 |
| R-HSA-9830364 | Formation of the nephric duct | 1.958829e-02 | 1.708 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.052660e-02 | 1.688 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.995214e-02 | 1.700 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.058446e-02 | 1.686 |
| R-HSA-1500931 | Cell-Cell communication | 2.151834e-02 | 1.667 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 3.573873e-02 | 1.447 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 3.573873e-02 | 1.447 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.573873e-02 | 1.447 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.573873e-02 | 1.447 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.312784e-02 | 1.275 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.312784e-02 | 1.275 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 5.312784e-02 | 1.275 |
| R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | 5.312784e-02 | 1.275 |
| R-HSA-3560796 | Defective PAPSS2 causes SEMD-PA | 7.020441e-02 | 1.154 |
| R-HSA-5579016 | Defective UGT1A4 causes hyperbilirubinemia | 7.020441e-02 | 1.154 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 8.697404e-02 | 1.061 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 1.034422e-01 | 0.985 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 2.387418e-02 | 1.622 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 1.196144e-01 | 0.922 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 1.196144e-01 | 0.922 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.354958e-01 | 0.868 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 1.354958e-01 | 0.868 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 4.315490e-02 | 1.365 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 1.510917e-01 | 0.821 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 4.752311e-02 | 1.323 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.664072e-01 | 0.779 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.664072e-01 | 0.779 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.664072e-01 | 0.779 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 5.671337e-02 | 1.246 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.814472e-01 | 0.741 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.675150e-02 | 1.573 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 7.153254e-02 | 1.145 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.962169e-01 | 0.707 |
| R-HSA-170984 | ARMS-mediated activation | 1.962169e-01 | 0.707 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 7.672238e-02 | 1.115 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 7.672238e-02 | 1.115 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 7.672238e-02 | 1.115 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.672238e-02 | 1.115 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.672238e-02 | 1.115 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 8.202719e-02 | 1.086 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.107209e-01 | 0.676 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 8.744115e-02 | 1.058 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.249641e-01 | 0.648 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.249641e-01 | 0.648 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.389511e-01 | 0.622 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.389511e-01 | 0.622 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.389511e-01 | 0.622 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.100784e-01 | 0.958 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.159570e-01 | 0.936 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.526866e-01 | 0.597 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.526866e-01 | 0.597 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.526866e-01 | 0.597 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.526866e-01 | 0.597 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.526866e-01 | 0.597 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.526866e-01 | 0.597 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.661750e-01 | 0.575 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.661750e-01 | 0.575 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.402031e-01 | 0.853 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 8.349741e-02 | 1.078 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.924281e-01 | 0.534 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.924281e-01 | 0.534 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.924281e-01 | 0.534 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.924281e-01 | 0.534 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 3.052016e-01 | 0.515 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 3.052016e-01 | 0.515 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.177452e-01 | 0.498 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 3.300631e-01 | 0.481 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.044754e-01 | 0.689 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 3.421594e-01 | 0.466 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.417581e-02 | 1.026 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.417581e-02 | 1.026 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.490871e-01 | 0.827 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.657028e-01 | 0.437 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.771577e-01 | 0.423 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.072871e-01 | 0.683 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.846226e-01 | 0.546 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.980010e-01 | 0.526 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.046764e-01 | 0.516 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.046764e-01 | 0.516 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.378447e-01 | 0.471 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.444254e-01 | 0.463 |
| R-HSA-191859 | snRNP Assembly | 3.444254e-01 | 0.463 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.935231e-01 | 0.713 |
| R-HSA-72172 | mRNA Splicing | 1.172558e-01 | 0.931 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.867144e-02 | 1.006 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.673732e-02 | 1.014 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.097130e-02 | 1.092 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 5.263467e-02 | 1.279 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.836493e-02 | 1.547 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.444254e-01 | 0.463 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.458266e-01 | 0.836 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.029624e-01 | 0.693 |
| R-HSA-156711 | Polo-like kinase mediated events | 6.646362e-02 | 1.177 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.107209e-01 | 0.676 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 9.758263e-02 | 1.011 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.511087e-01 | 0.600 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.976607e-02 | 1.400 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.847916e-01 | 0.733 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.664072e-01 | 0.779 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 5.671337e-02 | 1.246 |
| R-HSA-190873 | Gap junction degradation | 1.962169e-01 | 0.707 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.962169e-01 | 0.707 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.469760e-02 | 1.350 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.526866e-01 | 0.597 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.913157e-01 | 0.536 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 5.671337e-02 | 1.246 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 3.540380e-01 | 0.451 |
| R-HSA-5693538 | Homology Directed Repair | 2.211337e-01 | 0.655 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 2.526866e-01 | 0.597 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.578107e-01 | 0.589 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.578107e-01 | 0.589 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.578107e-01 | 0.589 |
| R-HSA-6798695 | Neutrophil degranulation | 2.565295e-01 | 0.591 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 1.913238e-01 | 0.718 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.985875e-01 | 0.702 |
| R-HSA-72200 | mRNA Editing: C to U Conversion | 1.664072e-01 | 0.779 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.962169e-01 | 0.707 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.512853e-02 | 1.454 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.389511e-01 | 0.622 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.827703e-02 | 1.235 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.794207e-01 | 0.554 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 1.654097e-01 | 0.781 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.177452e-01 | 0.498 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.913238e-01 | 0.718 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.177227e-01 | 0.662 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.243748e-01 | 0.649 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 2.310421e-01 | 0.636 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.511087e-01 | 0.600 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.779234e-01 | 0.556 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.044754e-01 | 0.689 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.597344e-02 | 1.119 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.490871e-01 | 0.827 |
| R-HSA-68877 | Mitotic Prometaphase | 9.497864e-02 | 1.022 |
| R-HSA-5689603 | UCH proteinases | 1.980044e-01 | 0.703 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.145745e-02 | 1.039 |
| R-HSA-9839394 | TGFBR3 expression | 1.100784e-01 | 0.958 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.654097e-01 | 0.781 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.022235e-01 | 0.990 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.179905e-01 | 0.498 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.326532e-01 | 0.633 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.664072e-01 | 0.779 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.590324e-01 | 0.799 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.177452e-01 | 0.498 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.590324e-01 | 0.799 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 2.389511e-01 | 0.622 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 6.724978e-02 | 1.172 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.243748e-01 | 0.649 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.046764e-01 | 0.516 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.509848e-01 | 0.455 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.509848e-01 | 0.455 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.509848e-01 | 0.455 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.509848e-01 | 0.455 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.243748e-01 | 0.649 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.578107e-01 | 0.589 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 3.052016e-01 | 0.515 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.576724e-01 | 0.802 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.039707e-01 | 0.517 |
| R-HSA-69541 | Stabilization of p53 | 2.044754e-01 | 0.689 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.246257e-01 | 0.489 |
| R-HSA-5358508 | Mismatch Repair | 3.421594e-01 | 0.466 |
| R-HSA-6807070 | PTEN Regulation | 3.164565e-01 | 0.500 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 7.020441e-02 | 1.154 |
| R-HSA-75094 | Formation of the Editosome | 1.354958e-01 | 0.868 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.354958e-01 | 0.868 |
| R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | 1.510917e-01 | 0.821 |
| R-HSA-196025 | Formation of annular gap junctions | 1.814472e-01 | 0.741 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.107209e-01 | 0.676 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.976607e-02 | 1.400 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 2.249641e-01 | 0.648 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.389511e-01 | 0.622 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.389511e-01 | 0.622 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.526866e-01 | 0.597 |
| R-HSA-8949613 | Cristae formation | 1.219134e-01 | 0.914 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.340409e-01 | 0.873 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 7.355999e-02 | 1.133 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.464251e-01 | 0.834 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.924281e-01 | 0.534 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.973613e-02 | 1.224 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.300631e-01 | 0.481 |
| R-HSA-164378 | PKA activation in glucagon signalling | 3.421594e-01 | 0.466 |
| R-HSA-437239 | Recycling pathway of L1 | 2.645154e-01 | 0.578 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.173534e-01 | 0.931 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.059313e-02 | 1.043 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.744640e-01 | 0.562 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 6.419221e-02 | 1.193 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 8.744115e-02 | 1.058 |
| R-HSA-8951664 | Neddylation | 2.767871e-01 | 0.558 |
| R-HSA-9909396 | Circadian clock | 1.351419e-01 | 0.869 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 5.542130e-02 | 1.256 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 2.526866e-01 | 0.597 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.300631e-01 | 0.481 |
| R-HSA-68875 | Mitotic Prophase | 9.987660e-02 | 1.001 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.340409e-01 | 0.873 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.999252e-02 | 1.155 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.324012e-01 | 0.878 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.949005e-01 | 0.710 |
| R-HSA-73894 | DNA Repair | 1.584395e-01 | 0.800 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 1.034422e-01 | 0.985 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.991798e-02 | 1.302 |
| R-HSA-174362 | Transport and metabolism of PAPS | 2.924281e-01 | 0.534 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.052016e-01 | 0.515 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.300631e-01 | 0.481 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.708260e-01 | 0.767 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.578107e-01 | 0.589 |
| R-HSA-912446 | Meiotic recombination | 2.913157e-01 | 0.536 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.913157e-01 | 0.536 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.941109e-01 | 0.531 |
| R-HSA-9707616 | Heme signaling | 3.640349e-01 | 0.439 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.990386e-01 | 0.524 |
| R-HSA-68886 | M Phase | 6.733166e-02 | 1.172 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.590324e-01 | 0.799 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.177452e-01 | 0.498 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.827703e-02 | 1.235 |
| R-HSA-156588 | Glucuronidation | 1.049627e-01 | 0.979 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.605337e-02 | 1.337 |
| R-HSA-114608 | Platelet degranulation | 4.707612e-02 | 1.327 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.779234e-01 | 0.556 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.779234e-01 | 0.556 |
| R-HSA-1268020 | Mitochondrial protein import | 3.640349e-01 | 0.439 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.640349e-01 | 0.439 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.578210e-01 | 0.802 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 8.697404e-02 | 1.061 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 1.354958e-01 | 0.868 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.814472e-01 | 0.741 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.814472e-01 | 0.741 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.814472e-01 | 0.741 |
| R-HSA-71032 | Propionyl-CoA catabolism | 2.249641e-01 | 0.648 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.389511e-01 | 0.622 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.389511e-01 | 0.622 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 2.389511e-01 | 0.622 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.159570e-01 | 0.936 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.794207e-01 | 0.554 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.924281e-01 | 0.534 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.177452e-01 | 0.498 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.421594e-01 | 0.466 |
| R-HSA-9834899 | Specification of the neural plate border | 3.540380e-01 | 0.451 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.540380e-01 | 0.451 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 3.657028e-01 | 0.437 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.771577e-01 | 0.423 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.142481e-01 | 0.942 |
| R-HSA-182971 | EGFR downregulation | 1.464251e-01 | 0.834 |
| R-HSA-169893 | Prolonged ERK activation events | 3.052016e-01 | 0.515 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.782929e-01 | 0.749 |
| R-HSA-9824272 | Somitogenesis | 2.511087e-01 | 0.600 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.312444e-01 | 0.480 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.509848e-01 | 0.455 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.259168e-01 | 0.900 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.023745e-02 | 1.153 |
| R-HSA-9629569 | Protein hydroxylation | 7.672238e-02 | 1.115 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 1.203500e-01 | 0.920 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.444254e-01 | 0.463 |
| R-HSA-1474290 | Collagen formation | 2.941109e-01 | 0.531 |
| R-HSA-9758941 | Gastrulation | 1.904120e-01 | 0.720 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.003086e-01 | 0.999 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.510917e-01 | 0.821 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.219538e-02 | 1.375 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 3.300631e-01 | 0.481 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.676589e-02 | 1.246 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.640349e-01 | 0.439 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.705229e-01 | 0.431 |
| R-HSA-446728 | Cell junction organization | 4.820133e-02 | 1.317 |
| R-HSA-74160 | Gene expression (Transcription) | 3.353526e-01 | 0.474 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 9.397522e-02 | 1.027 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.509848e-01 | 0.455 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.089066e-01 | 0.510 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.484229e-01 | 0.458 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.246881e-01 | 0.489 |
| R-HSA-8982491 | Glycogen metabolism | 5.542130e-02 | 1.256 |
| R-HSA-418990 | Adherens junctions interactions | 1.463607e-01 | 0.835 |
| R-HSA-421270 | Cell-cell junction organization | 1.244713e-01 | 0.905 |
| R-HSA-2559583 | Cellular Senescence | 2.971026e-01 | 0.527 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.136983e-02 | 1.503 |
| R-HSA-844455 | The NLRP1 inflammasome | 8.697404e-02 | 1.061 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 1.354958e-01 | 0.868 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.664072e-01 | 0.779 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.962169e-01 | 0.707 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.526866e-01 | 0.597 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.526866e-01 | 0.597 |
| R-HSA-446205 | Synthesis of GDP-mannose | 2.526866e-01 | 0.597 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 2.661750e-01 | 0.575 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.661750e-01 | 0.575 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.794207e-01 | 0.554 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.924281e-01 | 0.534 |
| R-HSA-9754706 | Atorvastatin ADME | 3.052016e-01 | 0.515 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 3.052016e-01 | 0.515 |
| R-HSA-163615 | PKA activation | 3.421594e-01 | 0.466 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.540380e-01 | 0.451 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.888270e-01 | 0.724 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.363571e-02 | 1.196 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.363571e-02 | 1.196 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.980010e-01 | 0.526 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.046764e-01 | 0.516 |
| R-HSA-212436 | Generic Transcription Pathway | 3.474107e-01 | 0.459 |
| R-HSA-157118 | Signaling by NOTCH | 1.050881e-01 | 0.978 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.452898e-01 | 0.610 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.488776e-02 | 1.126 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 8.202719e-02 | 1.086 |
| R-HSA-196780 | Biotin transport and metabolism | 2.924281e-01 | 0.534 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.873251e-02 | 1.542 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.166660e-01 | 0.664 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.568853e-02 | 1.590 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.385503e-01 | 0.470 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 3.490791e-02 | 1.457 |
| R-HSA-75072 | mRNA Editing | 1.962169e-01 | 0.707 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.526866e-01 | 0.597 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.590324e-01 | 0.799 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.658756e-01 | 0.575 |
| R-HSA-9830369 | Kidney development | 4.940636e-02 | 1.306 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.219538e-02 | 1.375 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.578107e-01 | 0.589 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.024911e-01 | 0.989 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.070721e-02 | 1.217 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.640349e-01 | 0.439 |
| R-HSA-1640170 | Cell Cycle | 4.629318e-02 | 1.334 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.196536e-01 | 0.922 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.354958e-01 | 0.868 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.249641e-01 | 0.648 |
| R-HSA-8851805 | MET activates RAS signaling | 2.526866e-01 | 0.597 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.794207e-01 | 0.554 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 3.421594e-01 | 0.466 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.803755e-01 | 0.744 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.327939e-01 | 0.478 |
| R-HSA-597592 | Post-translational protein modification | 3.479660e-01 | 0.458 |
| R-HSA-373760 | L1CAM interactions | 2.135415e-01 | 0.671 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.428845e-02 | 1.465 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 5.263467e-02 | 1.279 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.177452e-01 | 0.498 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.300631e-01 | 0.481 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.421594e-01 | 0.466 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.177227e-01 | 0.662 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.210923e-02 | 1.086 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.243748e-01 | 0.649 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.042491e-01 | 0.517 |
| R-HSA-5619084 | ABC transporter disorders | 2.072871e-01 | 0.683 |
| R-HSA-70171 | Glycolysis | 3.286692e-01 | 0.483 |
| R-HSA-1989781 | PPARA activates gene expression | 9.843758e-02 | 1.007 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.354958e-01 | 0.868 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.962169e-01 | 0.707 |
| R-HSA-5689877 | Josephin domain DUBs | 2.107209e-01 | 0.676 |
| R-HSA-70370 | Galactose catabolism | 3.177452e-01 | 0.498 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.300631e-01 | 0.481 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.421594e-01 | 0.466 |
| R-HSA-71288 | Creatine metabolism | 3.657028e-01 | 0.437 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.173285e-01 | 0.663 |
| R-HSA-69481 | G2/M Checkpoints | 2.600630e-01 | 0.585 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.737506e-01 | 0.427 |
| R-HSA-68882 | Mitotic Anaphase | 1.420066e-01 | 0.848 |
| R-HSA-9823730 | Formation of definitive endoderm | 3.657028e-01 | 0.437 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.441757e-01 | 0.841 |
| R-HSA-9907900 | Proteasome assembly | 2.444116e-01 | 0.612 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.527029e-01 | 0.816 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.286692e-01 | 0.483 |
| R-HSA-162582 | Signal Transduction | 1.169380e-01 | 0.932 |
| R-HSA-73893 | DNA Damage Bypass | 2.779234e-01 | 0.556 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.545970e-01 | 0.811 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 1.196144e-01 | 0.922 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 5.671337e-02 | 1.246 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.107209e-01 | 0.676 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.924281e-01 | 0.534 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.125550e-01 | 0.949 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.300631e-01 | 0.481 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.771577e-01 | 0.423 |
| R-HSA-177929 | Signaling by EGFR | 3.246257e-01 | 0.489 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.640311e-01 | 0.578 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.087329e-01 | 0.964 |
| R-HSA-9031628 | NGF-stimulated transcription | 2.712203e-01 | 0.567 |
| R-HSA-8983711 | OAS antiviral response | 2.526866e-01 | 0.597 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.782929e-01 | 0.749 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.924281e-01 | 0.534 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.540380e-01 | 0.451 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 3.771577e-01 | 0.423 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.578107e-01 | 0.589 |
| R-HSA-75893 | TNF signaling | 3.246257e-01 | 0.489 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.360156e-01 | 0.866 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.125550e-01 | 0.949 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.255613e-01 | 0.647 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 9.857419e-02 | 1.006 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.159570e-01 | 0.936 |
| R-HSA-8876725 | Protein methylation | 2.924281e-01 | 0.534 |
| R-HSA-5635838 | Activation of SMO | 3.052016e-01 | 0.515 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.177452e-01 | 0.498 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.771577e-01 | 0.423 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 2.779234e-01 | 0.556 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.814472e-01 | 0.741 |
| R-HSA-9678110 | Attachment and Entry | 3.052016e-01 | 0.515 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.404749e-01 | 0.619 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.924281e-01 | 0.534 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 9.758263e-02 | 1.011 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 1.243205e-01 | 0.905 |
| R-HSA-166520 | Signaling by NTRKs | 3.573672e-01 | 0.447 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.644350e-02 | 1.016 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 1.042825e-01 | 0.982 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 1.576724e-01 | 0.802 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.657028e-01 | 0.437 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.632022e-01 | 0.440 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.292137e-02 | 1.483 |
| R-HSA-373753 | Nephrin family interactions | 7.672238e-02 | 1.115 |
| R-HSA-435354 | Zinc transporters | 2.794207e-01 | 0.554 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 1.243205e-01 | 0.905 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 9.693212e-02 | 1.014 |
| R-HSA-9833482 | PKR-mediated signaling | 7.844842e-02 | 1.105 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.402031e-01 | 0.853 |
| R-HSA-73887 | Death Receptor Signaling | 2.061430e-01 | 0.686 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.072871e-01 | 0.683 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.842807e-01 | 0.735 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.718311e-01 | 0.765 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.557476e-02 | 1.341 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.835640e-01 | 0.736 |
| R-HSA-75153 | Apoptotic execution phase | 7.681058e-02 | 1.115 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.219134e-01 | 0.914 |
| R-HSA-379724 | tRNA Aminoacylation | 3.509848e-01 | 0.455 |
| R-HSA-3322077 | Glycogen synthesis | 3.657028e-01 | 0.437 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.769845e-01 | 0.424 |
| R-HSA-109581 | Apoptosis | 1.130013e-01 | 0.947 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.847916e-01 | 0.733 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.796682e-01 | 0.553 |
| R-HSA-9020591 | Interleukin-12 signaling | 6.876165e-02 | 1.163 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.421594e-01 | 0.466 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.246257e-01 | 0.489 |
| R-HSA-5357801 | Programmed Cell Death | 2.286967e-01 | 0.641 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.378447e-01 | 0.471 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.237273e-01 | 0.490 |
| R-HSA-447115 | Interleukin-12 family signaling | 9.972596e-02 | 1.001 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.819320e-01 | 0.418 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.884064e-01 | 0.411 |
| R-HSA-9755088 | Ribavirin ADME | 3.884064e-01 | 0.411 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.884064e-01 | 0.411 |
| R-HSA-9694614 | Attachment and Entry | 3.884064e-01 | 0.411 |
| R-HSA-449147 | Signaling by Interleukins | 3.953516e-01 | 0.403 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.962001e-01 | 0.402 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 3.994526e-01 | 0.399 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.994526e-01 | 0.399 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.994526e-01 | 0.399 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.994526e-01 | 0.399 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.994526e-01 | 0.399 |
| R-HSA-8964038 | LDL clearance | 3.994526e-01 | 0.399 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.994526e-01 | 0.399 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.025454e-01 | 0.395 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.103000e-01 | 0.387 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 4.103000e-01 | 0.387 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 4.103000e-01 | 0.387 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 4.103000e-01 | 0.387 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 4.103000e-01 | 0.387 |
| R-HSA-9830674 | Formation of the ureteric bud | 4.103000e-01 | 0.387 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 4.103000e-01 | 0.387 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 4.103000e-01 | 0.387 |
| R-HSA-3000170 | Syndecan interactions | 4.103000e-01 | 0.387 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.119847e-01 | 0.385 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.151400e-01 | 0.382 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.209521e-01 | 0.376 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.209521e-01 | 0.376 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 4.209521e-01 | 0.376 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.209521e-01 | 0.376 |
| R-HSA-9865881 | Complex III assembly | 4.209521e-01 | 0.376 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.213876e-01 | 0.375 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.213876e-01 | 0.375 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.213876e-01 | 0.375 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.213876e-01 | 0.375 |
| R-HSA-70326 | Glucose metabolism | 4.264088e-01 | 0.370 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.264088e-01 | 0.370 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.276009e-01 | 0.369 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.276009e-01 | 0.369 |
| R-HSA-420029 | Tight junction interactions | 4.314125e-01 | 0.365 |
| R-HSA-2160916 | Hyaluronan degradation | 4.314125e-01 | 0.365 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.314125e-01 | 0.365 |
| R-HSA-3000157 | Laminin interactions | 4.314125e-01 | 0.365 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.327590e-01 | 0.364 |
| R-HSA-4086398 | Ca2+ pathway | 4.337792e-01 | 0.363 |
| R-HSA-9749641 | Aspirin ADME | 4.337792e-01 | 0.363 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.399216e-01 | 0.357 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.416845e-01 | 0.355 |
| R-HSA-525793 | Myogenesis | 4.416845e-01 | 0.355 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 4.416845e-01 | 0.355 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.456702e-01 | 0.351 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.460275e-01 | 0.351 |
| R-HSA-8852135 | Protein ubiquitination | 4.460275e-01 | 0.351 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.517716e-01 | 0.345 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.517716e-01 | 0.345 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.517716e-01 | 0.345 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 4.517716e-01 | 0.345 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.517716e-01 | 0.345 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 4.517716e-01 | 0.345 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.520961e-01 | 0.345 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.540814e-01 | 0.343 |
| R-HSA-913531 | Interferon Signaling | 4.540814e-01 | 0.343 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.595579e-01 | 0.338 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 4.616770e-01 | 0.336 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 4.616770e-01 | 0.336 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.616770e-01 | 0.336 |
| R-HSA-9757110 | Prednisone ADME | 4.616770e-01 | 0.336 |
| R-HSA-622312 | Inflammasomes | 4.616770e-01 | 0.336 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.640430e-01 | 0.333 |
| R-HSA-4086400 | PCP/CE pathway | 4.641191e-01 | 0.333 |
| R-HSA-216083 | Integrin cell surface interactions | 4.641191e-01 | 0.333 |
| R-HSA-194138 | Signaling by VEGF | 4.688813e-01 | 0.329 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.710111e-01 | 0.327 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.710267e-01 | 0.327 |
| R-HSA-72086 | mRNA Capping | 4.714041e-01 | 0.327 |
| R-HSA-420092 | Glucagon-type ligand receptors | 4.714041e-01 | 0.327 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.714041e-01 | 0.327 |
| R-HSA-6806834 | Signaling by MET | 4.759860e-01 | 0.322 |
| R-HSA-1280218 | Adaptive Immune System | 4.783791e-01 | 0.320 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.809559e-01 | 0.318 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.809559e-01 | 0.318 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.809559e-01 | 0.318 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.818595e-01 | 0.317 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.881281e-01 | 0.311 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.903358e-01 | 0.310 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.903358e-01 | 0.310 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.903358e-01 | 0.310 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.903358e-01 | 0.310 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.903358e-01 | 0.310 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.917390e-01 | 0.308 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.934842e-01 | 0.307 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.992346e-01 | 0.302 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.992346e-01 | 0.302 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.995467e-01 | 0.301 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.995467e-01 | 0.301 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.016078e-01 | 0.300 |
| R-HSA-1500620 | Meiosis | 5.049432e-01 | 0.297 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.085918e-01 | 0.294 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.085918e-01 | 0.294 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.085918e-01 | 0.294 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.085918e-01 | 0.294 |
| R-HSA-9733709 | Cardiogenesis | 5.085918e-01 | 0.294 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 5.085918e-01 | 0.294 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.085918e-01 | 0.294 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.115043e-01 | 0.291 |
| R-HSA-69275 | G2/M Transition | 5.130716e-01 | 0.290 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.162332e-01 | 0.287 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.162332e-01 | 0.287 |
| R-HSA-390522 | Striated Muscle Contraction | 5.174738e-01 | 0.286 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.174738e-01 | 0.286 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 5.174738e-01 | 0.286 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.174738e-01 | 0.286 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.174738e-01 | 0.286 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.174738e-01 | 0.286 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.174738e-01 | 0.286 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.174738e-01 | 0.286 |
| R-HSA-189483 | Heme degradation | 5.174738e-01 | 0.286 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.174738e-01 | 0.286 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 5.174738e-01 | 0.286 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.206471e-01 | 0.283 |
| R-HSA-195721 | Signaling by WNT | 5.206873e-01 | 0.283 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.258864e-01 | 0.279 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.261959e-01 | 0.279 |
| R-HSA-5673000 | RAF activation | 5.261959e-01 | 0.279 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.261959e-01 | 0.279 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.261959e-01 | 0.279 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.261959e-01 | 0.279 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.261959e-01 | 0.279 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.261959e-01 | 0.279 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.261959e-01 | 0.279 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.261959e-01 | 0.279 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.261959e-01 | 0.279 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.261959e-01 | 0.279 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.261959e-01 | 0.279 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.275938e-01 | 0.278 |
| R-HSA-163685 | Integration of energy metabolism | 5.275938e-01 | 0.278 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.319055e-01 | 0.274 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.328462e-01 | 0.273 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.347609e-01 | 0.272 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.347609e-01 | 0.272 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.347609e-01 | 0.272 |
| R-HSA-169911 | Regulation of Apoptosis | 5.347609e-01 | 0.272 |
| R-HSA-187687 | Signalling to ERKs | 5.347609e-01 | 0.272 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 5.347609e-01 | 0.272 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.355702e-01 | 0.271 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.356294e-01 | 0.271 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.363073e-01 | 0.271 |
| R-HSA-202424 | Downstream TCR signaling | 5.382969e-01 | 0.269 |
| R-HSA-4839726 | Chromatin organization | 5.421635e-01 | 0.266 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.431715e-01 | 0.265 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.431715e-01 | 0.265 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.431715e-01 | 0.265 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.431715e-01 | 0.265 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.431715e-01 | 0.265 |
| R-HSA-111933 | Calmodulin induced events | 5.431715e-01 | 0.265 |
| R-HSA-111997 | CaM pathway | 5.431715e-01 | 0.265 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.473812e-01 | 0.262 |
| R-HSA-1632852 | Macroautophagy | 5.492053e-01 | 0.260 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.514306e-01 | 0.259 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.514306e-01 | 0.259 |
| R-HSA-4641258 | Degradation of DVL | 5.514306e-01 | 0.259 |
| R-HSA-4641257 | Degradation of AXIN | 5.514306e-01 | 0.259 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.514306e-01 | 0.259 |
| R-HSA-419037 | NCAM1 interactions | 5.514306e-01 | 0.259 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.514306e-01 | 0.259 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.514306e-01 | 0.259 |
| R-HSA-8948216 | Collagen chain trimerization | 5.514306e-01 | 0.259 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.543849e-01 | 0.256 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.595409e-01 | 0.252 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.595409e-01 | 0.252 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.595409e-01 | 0.252 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.675051e-01 | 0.246 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.675051e-01 | 0.246 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.675051e-01 | 0.246 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.675051e-01 | 0.246 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.675051e-01 | 0.246 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.675051e-01 | 0.246 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 5.675051e-01 | 0.246 |
| R-HSA-9648002 | RAS processing | 5.675051e-01 | 0.246 |
| R-HSA-201556 | Signaling by ALK | 5.675051e-01 | 0.246 |
| R-HSA-168256 | Immune System | 5.743112e-01 | 0.241 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.753257e-01 | 0.240 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.753257e-01 | 0.240 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.753257e-01 | 0.240 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.753257e-01 | 0.240 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.753257e-01 | 0.240 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.753257e-01 | 0.240 |
| R-HSA-5260271 | Diseases of Immune System | 5.753257e-01 | 0.240 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.753257e-01 | 0.240 |
| R-HSA-167169 | HIV Transcription Elongation | 5.753257e-01 | 0.240 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 5.753257e-01 | 0.240 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5.753257e-01 | 0.240 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.753257e-01 | 0.240 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.753257e-01 | 0.240 |
| R-HSA-9646399 | Aggrephagy | 5.753257e-01 | 0.240 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 5.753257e-01 | 0.240 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.753257e-01 | 0.240 |
| R-HSA-168249 | Innate Immune System | 5.777229e-01 | 0.238 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.803090e-01 | 0.236 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.803090e-01 | 0.236 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.825484e-01 | 0.235 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.830054e-01 | 0.234 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.830054e-01 | 0.234 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.830054e-01 | 0.234 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.830054e-01 | 0.234 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.830054e-01 | 0.234 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 5.830054e-01 | 0.234 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.870337e-01 | 0.231 |
| R-HSA-422356 | Regulation of insulin secretion | 5.903651e-01 | 0.229 |
| R-HSA-190236 | Signaling by FGFR | 5.903651e-01 | 0.229 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 5.905466e-01 | 0.229 |
| R-HSA-167161 | HIV Transcription Initiation | 5.905466e-01 | 0.229 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 5.905466e-01 | 0.229 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.905466e-01 | 0.229 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.905466e-01 | 0.229 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.905466e-01 | 0.229 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.905466e-01 | 0.229 |
| R-HSA-3214847 | HATs acetylate histones | 5.953257e-01 | 0.225 |
| R-HSA-991365 | Activation of GABAB receptors | 5.979520e-01 | 0.223 |
| R-HSA-977444 | GABA B receptor activation | 5.979520e-01 | 0.223 |
| R-HSA-165159 | MTOR signalling | 5.979520e-01 | 0.223 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.979520e-01 | 0.223 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.979520e-01 | 0.223 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.979520e-01 | 0.223 |
| R-HSA-111996 | Ca-dependent events | 5.979520e-01 | 0.223 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.979520e-01 | 0.223 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.002414e-01 | 0.222 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.051121e-01 | 0.218 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.052238e-01 | 0.218 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 6.052238e-01 | 0.218 |
| R-HSA-1483255 | PI Metabolism | 6.099379e-01 | 0.215 |
| R-HSA-190828 | Gap junction trafficking | 6.123646e-01 | 0.213 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 6.123646e-01 | 0.213 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.123646e-01 | 0.213 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.123646e-01 | 0.213 |
| R-HSA-9612973 | Autophagy | 6.142929e-01 | 0.212 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.193766e-01 | 0.208 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.193766e-01 | 0.208 |
| R-HSA-774815 | Nucleosome assembly | 6.193766e-01 | 0.208 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 6.193766e-01 | 0.208 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 6.193766e-01 | 0.208 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 6.193766e-01 | 0.208 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.193766e-01 | 0.208 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 6.193766e-01 | 0.208 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.193766e-01 | 0.208 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.193766e-01 | 0.208 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 6.193766e-01 | 0.208 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.193766e-01 | 0.208 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.219717e-01 | 0.206 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.241460e-01 | 0.205 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.241460e-01 | 0.205 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.262623e-01 | 0.203 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.262623e-01 | 0.203 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 6.262623e-01 | 0.203 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.262623e-01 | 0.203 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.262623e-01 | 0.203 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.287925e-01 | 0.201 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.287925e-01 | 0.201 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.330237e-01 | 0.199 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.330237e-01 | 0.199 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.330237e-01 | 0.199 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.330237e-01 | 0.199 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.380748e-01 | 0.195 |
| R-HSA-9634597 | GPER1 signaling | 6.396633e-01 | 0.194 |
| R-HSA-70263 | Gluconeogenesis | 6.396633e-01 | 0.194 |
| R-HSA-425410 | Metal ion SLC transporters | 6.396633e-01 | 0.194 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.424644e-01 | 0.192 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.461831e-01 | 0.190 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.513571e-01 | 0.186 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.513571e-01 | 0.186 |
| R-HSA-202403 | TCR signaling | 6.513571e-01 | 0.186 |
| R-HSA-109704 | PI3K Cascade | 6.525854e-01 | 0.185 |
| R-HSA-9748787 | Azathioprine ADME | 6.525854e-01 | 0.185 |
| R-HSA-162906 | HIV Infection | 6.586869e-01 | 0.181 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.600736e-01 | 0.180 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.640431e-01 | 0.178 |
| R-HSA-72187 | mRNA 3'-end processing | 6.650456e-01 | 0.177 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.650456e-01 | 0.177 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.650456e-01 | 0.177 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.650456e-01 | 0.177 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.650456e-01 | 0.177 |
| R-HSA-392499 | Metabolism of proteins | 6.655110e-01 | 0.177 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.711077e-01 | 0.173 |
| R-HSA-1221632 | Meiotic synapsis | 6.711077e-01 | 0.173 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.711077e-01 | 0.173 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.711077e-01 | 0.173 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.711077e-01 | 0.173 |
| R-HSA-8956320 | Nucleotide biosynthesis | 6.711077e-01 | 0.173 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.769825e-01 | 0.169 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.770604e-01 | 0.169 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.770604e-01 | 0.169 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.811016e-01 | 0.167 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.829058e-01 | 0.166 |
| R-HSA-418597 | G alpha (z) signalling events | 6.829058e-01 | 0.166 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.886457e-01 | 0.162 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.886457e-01 | 0.162 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.886457e-01 | 0.162 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.886457e-01 | 0.162 |
| R-HSA-8939211 | ESR-mediated signaling | 6.886967e-01 | 0.162 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.932024e-01 | 0.159 |
| R-HSA-112399 | IRS-mediated signalling | 6.942820e-01 | 0.158 |
| R-HSA-5621480 | Dectin-2 family | 6.942820e-01 | 0.158 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.942820e-01 | 0.158 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.971511e-01 | 0.157 |
| R-HSA-6782135 | Dual incision in TC-NER | 6.998167e-01 | 0.155 |
| R-HSA-4085001 | Sialic acid metabolism | 7.052515e-01 | 0.152 |
| R-HSA-186712 | Regulation of beta-cell development | 7.052515e-01 | 0.152 |
| R-HSA-977443 | GABA receptor activation | 7.105882e-01 | 0.148 |
| R-HSA-983189 | Kinesins | 7.105882e-01 | 0.148 |
| R-HSA-351202 | Metabolism of polyamines | 7.105882e-01 | 0.148 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.125282e-01 | 0.147 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.125282e-01 | 0.147 |
| R-HSA-3781865 | Diseases of glycosylation | 7.153149e-01 | 0.146 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.158286e-01 | 0.145 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.158286e-01 | 0.145 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.158286e-01 | 0.145 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 7.158286e-01 | 0.145 |
| R-HSA-445717 | Aquaporin-mediated transport | 7.158286e-01 | 0.145 |
| R-HSA-450294 | MAP kinase activation | 7.158286e-01 | 0.145 |
| R-HSA-112043 | PLC beta mediated events | 7.158286e-01 | 0.145 |
| R-HSA-1442490 | Collagen degradation | 7.158286e-01 | 0.145 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.209745e-01 | 0.142 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.209745e-01 | 0.142 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.209745e-01 | 0.142 |
| R-HSA-186797 | Signaling by PDGF | 7.209745e-01 | 0.142 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 7.209745e-01 | 0.142 |
| R-HSA-9679506 | SARS-CoV Infections | 7.232028e-01 | 0.141 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.236287e-01 | 0.140 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.236287e-01 | 0.140 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.236287e-01 | 0.140 |
| R-HSA-2428924 | IGF1R signaling cascade | 7.309893e-01 | 0.136 |
| R-HSA-74751 | Insulin receptor signalling cascade | 7.309893e-01 | 0.136 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 7.358615e-01 | 0.133 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.420499e-01 | 0.130 |
| R-HSA-1474165 | Reproduction | 7.447474e-01 | 0.128 |
| R-HSA-112040 | G-protein mediated events | 7.453437e-01 | 0.128 |
| R-HSA-9843745 | Adipogenesis | 7.481300e-01 | 0.126 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 7.481300e-01 | 0.126 |
| R-HSA-913709 | O-linked glycosylation of mucins | 7.499568e-01 | 0.125 |
| R-HSA-167172 | Transcription of the HIV genome | 7.499568e-01 | 0.125 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 7.499568e-01 | 0.125 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.499568e-01 | 0.125 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.514741e-01 | 0.124 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 7.589346e-01 | 0.120 |
| R-HSA-448424 | Interleukin-17 signaling | 7.589346e-01 | 0.120 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.589346e-01 | 0.120 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.589346e-01 | 0.120 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 7.633023e-01 | 0.117 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 7.633023e-01 | 0.117 |
| R-HSA-3000178 | ECM proteoglycans | 7.633023e-01 | 0.117 |
| R-HSA-189445 | Metabolism of porphyrins | 7.633023e-01 | 0.117 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.675912e-01 | 0.115 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.675912e-01 | 0.115 |
| R-HSA-74259 | Purine catabolism | 7.675912e-01 | 0.115 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.696400e-01 | 0.114 |
| R-HSA-9675108 | Nervous system development | 7.705729e-01 | 0.113 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.718025e-01 | 0.112 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.718025e-01 | 0.112 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.759379e-01 | 0.110 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 7.759379e-01 | 0.110 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.759379e-01 | 0.110 |
| R-HSA-199991 | Membrane Trafficking | 7.779926e-01 | 0.109 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.799985e-01 | 0.108 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.799985e-01 | 0.108 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.799985e-01 | 0.108 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.839858e-01 | 0.106 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.870558e-01 | 0.104 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.887086e-01 | 0.103 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.917456e-01 | 0.101 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.944152e-01 | 0.100 |
| R-HSA-397014 | Muscle contraction | 7.946711e-01 | 0.100 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.946711e-01 | 0.100 |
| R-HSA-9659379 | Sensory processing of sound | 7.955207e-01 | 0.099 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.955207e-01 | 0.099 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.992276e-01 | 0.097 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.992276e-01 | 0.097 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.992276e-01 | 0.097 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.027205e-01 | 0.095 |
| R-HSA-69242 | S Phase | 8.054222e-01 | 0.094 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 8.064417e-01 | 0.093 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.064417e-01 | 0.093 |
| R-HSA-9748784 | Drug ADME | 8.085765e-01 | 0.092 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.099512e-01 | 0.092 |
| R-HSA-422475 | Axon guidance | 8.103121e-01 | 0.091 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.133974e-01 | 0.090 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.159035e-01 | 0.088 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.180582e-01 | 0.087 |
| R-HSA-9609507 | Protein localization | 8.184439e-01 | 0.087 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.201040e-01 | 0.086 |
| R-HSA-70268 | Pyruvate metabolism | 8.265703e-01 | 0.083 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 8.265703e-01 | 0.083 |
| R-HSA-162587 | HIV Life Cycle | 8.282952e-01 | 0.082 |
| R-HSA-9610379 | HCMV Late Events | 8.282952e-01 | 0.082 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.282952e-01 | 0.082 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.297160e-01 | 0.081 |
| R-HSA-9663891 | Selective autophagy | 8.297160e-01 | 0.081 |
| R-HSA-877300 | Interferon gamma signaling | 8.330387e-01 | 0.079 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.358380e-01 | 0.078 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.358380e-01 | 0.078 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.446120e-01 | 0.073 |
| R-HSA-391251 | Protein folding | 8.446120e-01 | 0.073 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.446120e-01 | 0.073 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.474316e-01 | 0.072 |
| R-HSA-5619102 | SLC transporter disorders | 8.508538e-01 | 0.070 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.511464e-01 | 0.070 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.529187e-01 | 0.069 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.582090e-01 | 0.066 |
| R-HSA-72306 | tRNA processing | 8.590985e-01 | 0.066 |
| R-HSA-418555 | G alpha (s) signalling events | 8.610937e-01 | 0.065 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.633098e-01 | 0.064 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.633098e-01 | 0.064 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.633098e-01 | 0.064 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.657911e-01 | 0.063 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.688192e-01 | 0.061 |
| R-HSA-9609646 | HCMV Infection | 8.699799e-01 | 0.060 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.706200e-01 | 0.060 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.717812e-01 | 0.060 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.729690e-01 | 0.059 |
| R-HSA-168255 | Influenza Infection | 8.761493e-01 | 0.057 |
| R-HSA-111885 | Opioid Signalling | 8.775405e-01 | 0.057 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.787237e-01 | 0.056 |
| R-HSA-9833110 | RSV-host interactions | 8.797643e-01 | 0.056 |
| R-HSA-1474244 | Extracellular matrix organization | 8.828154e-01 | 0.054 |
| R-HSA-69239 | Synthesis of DNA | 8.861973e-01 | 0.052 |
| R-HSA-211000 | Gene Silencing by RNA | 8.861973e-01 | 0.052 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.882644e-01 | 0.051 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.902942e-01 | 0.050 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.902942e-01 | 0.050 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.980522e-01 | 0.047 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.989348e-01 | 0.046 |
| R-HSA-9609690 | HCMV Early Events | 9.032817e-01 | 0.044 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.052634e-01 | 0.043 |
| R-HSA-1266738 | Developmental Biology | 9.069036e-01 | 0.042 |
| R-HSA-9007101 | Rab regulation of trafficking | 9.086760e-01 | 0.042 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.088071e-01 | 0.042 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.114580e-01 | 0.040 |
| R-HSA-5668914 | Diseases of metabolism | 9.117966e-01 | 0.040 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 9.119661e-01 | 0.040 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 9.119661e-01 | 0.040 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.127563e-01 | 0.040 |
| R-HSA-72766 | Translation | 9.136918e-01 | 0.039 |
| R-HSA-73886 | Chromosome Maintenance | 9.151380e-01 | 0.039 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 9.166810e-01 | 0.038 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 9.166810e-01 | 0.038 |
| R-HSA-69206 | G1/S Transition | 9.225784e-01 | 0.035 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.239865e-01 | 0.034 |
| R-HSA-1483257 | Phospholipid metabolism | 9.268700e-01 | 0.033 |
| R-HSA-8956319 | Nucleotide catabolism | 9.280597e-01 | 0.032 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.331541e-01 | 0.030 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.377490e-01 | 0.028 |
| R-HSA-5173105 | O-linked glycosylation | 9.401295e-01 | 0.027 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 9.401295e-01 | 0.027 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.426216e-01 | 0.026 |
| R-HSA-15869 | Metabolism of nucleotides | 9.476159e-01 | 0.023 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.501800e-01 | 0.022 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.537123e-01 | 0.021 |
| R-HSA-69306 | DNA Replication | 9.561967e-01 | 0.019 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.577787e-01 | 0.019 |
| R-HSA-109582 | Hemostasis | 9.588916e-01 | 0.018 |
| R-HSA-9824446 | Viral Infection Pathways | 9.599910e-01 | 0.018 |
| R-HSA-9711097 | Cellular response to starvation | 9.600455e-01 | 0.018 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.642217e-01 | 0.016 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.685471e-01 | 0.014 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.702375e-01 | 0.013 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.702375e-01 | 0.013 |
| R-HSA-611105 | Respiratory electron transport | 9.728558e-01 | 0.012 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.774238e-01 | 0.010 |
| R-HSA-5617833 | Cilium Assembly | 9.782410e-01 | 0.010 |
| R-HSA-112316 | Neuronal System | 9.786078e-01 | 0.009 |
| R-HSA-1643685 | Disease | 9.828270e-01 | 0.008 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.828794e-01 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 9.885037e-01 | 0.005 |
| R-HSA-72312 | rRNA processing | 9.901619e-01 | 0.004 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.910305e-01 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.930757e-01 | 0.003 |
| R-HSA-416476 | G alpha (q) signalling events | 9.945579e-01 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.955508e-01 | 0.002 |
| R-HSA-9658195 | Leishmania infection | 9.960286e-01 | 0.002 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.960286e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.966397e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.973086e-01 | 0.001 |
| R-HSA-5663205 | Infectious disease | 9.986240e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.989529e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.993935e-01 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 9.996266e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.996857e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999314e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999878e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999995e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.896 | 0.053 | 2 | 0.875 |
CDC7 |
0.893 | 0.088 | 1 | 0.879 |
PRKD1 |
0.890 | 0.170 | -3 | 0.827 |
PIM3 |
0.888 | 0.086 | -3 | 0.813 |
PRPK |
0.888 | -0.129 | -1 | 0.899 |
MOS |
0.886 | 0.055 | 1 | 0.903 |
PRKD2 |
0.885 | 0.144 | -3 | 0.767 |
CAMK1B |
0.885 | 0.035 | -3 | 0.866 |
GCN2 |
0.885 | -0.134 | 2 | 0.824 |
MAPKAPK3 |
0.885 | 0.102 | -3 | 0.785 |
ULK2 |
0.885 | -0.080 | 2 | 0.823 |
DSTYK |
0.883 | -0.014 | 2 | 0.894 |
NDR2 |
0.883 | 0.025 | -3 | 0.833 |
MARK4 |
0.883 | 0.088 | 4 | 0.847 |
WNK1 |
0.882 | 0.061 | -2 | 0.921 |
AMPKA1 |
0.882 | 0.110 | -3 | 0.857 |
ATR |
0.882 | 0.091 | 1 | 0.903 |
NUAK2 |
0.882 | 0.080 | -3 | 0.833 |
IKKB |
0.882 | -0.117 | -2 | 0.824 |
RAF1 |
0.882 | -0.129 | 1 | 0.868 |
BMPR2 |
0.881 | -0.129 | -2 | 0.928 |
NEK6 |
0.881 | 0.025 | -2 | 0.886 |
PDHK1 |
0.881 | -0.158 | 1 | 0.866 |
TSSK2 |
0.881 | 0.155 | -5 | 0.903 |
PDHK4 |
0.881 | -0.299 | 1 | 0.876 |
MTOR |
0.881 | -0.138 | 1 | 0.793 |
NLK |
0.880 | -0.007 | 1 | 0.830 |
CAMK2G |
0.879 | -0.079 | 2 | 0.822 |
TSSK1 |
0.879 | 0.154 | -3 | 0.869 |
TBK1 |
0.879 | -0.136 | 1 | 0.761 |
NIK |
0.879 | 0.026 | -3 | 0.888 |
CLK3 |
0.879 | 0.108 | 1 | 0.852 |
PIM1 |
0.879 | 0.115 | -3 | 0.765 |
PKN3 |
0.879 | 0.006 | -3 | 0.811 |
NDR1 |
0.879 | 0.013 | -3 | 0.835 |
MAPKAPK2 |
0.879 | 0.096 | -3 | 0.727 |
RSK2 |
0.878 | 0.055 | -3 | 0.761 |
AMPKA2 |
0.878 | 0.106 | -3 | 0.825 |
MST4 |
0.878 | 0.071 | 2 | 0.874 |
CDKL1 |
0.878 | -0.012 | -3 | 0.780 |
TGFBR2 |
0.878 | -0.022 | -2 | 0.815 |
BCKDK |
0.877 | -0.069 | -1 | 0.883 |
NEK7 |
0.876 | -0.103 | -3 | 0.853 |
HUNK |
0.876 | -0.037 | 2 | 0.812 |
CAMK2D |
0.876 | 0.022 | -3 | 0.853 |
PKCD |
0.876 | 0.086 | 2 | 0.823 |
CAMLCK |
0.875 | 0.003 | -2 | 0.893 |
WNK3 |
0.875 | -0.142 | 1 | 0.863 |
LATS2 |
0.875 | 0.008 | -5 | 0.780 |
IKKE |
0.875 | -0.162 | 1 | 0.753 |
CHAK2 |
0.874 | -0.020 | -1 | 0.868 |
ERK5 |
0.874 | -0.031 | 1 | 0.768 |
PKN2 |
0.874 | 0.021 | -3 | 0.846 |
NIM1 |
0.874 | 0.001 | 3 | 0.786 |
MLK1 |
0.874 | -0.088 | 2 | 0.839 |
DAPK2 |
0.874 | -0.003 | -3 | 0.870 |
P90RSK |
0.873 | 0.003 | -3 | 0.753 |
SKMLCK |
0.873 | 0.010 | -2 | 0.894 |
MELK |
0.873 | 0.057 | -3 | 0.819 |
RIPK3 |
0.873 | -0.118 | 3 | 0.713 |
HIPK4 |
0.873 | 0.020 | 1 | 0.797 |
NEK9 |
0.872 | -0.068 | 2 | 0.871 |
PRKD3 |
0.872 | 0.073 | -3 | 0.746 |
P70S6KB |
0.872 | 0.024 | -3 | 0.795 |
MLK2 |
0.871 | -0.022 | 2 | 0.853 |
RSK3 |
0.871 | 0.008 | -3 | 0.747 |
GRK5 |
0.871 | -0.166 | -3 | 0.852 |
ULK1 |
0.871 | -0.184 | -3 | 0.828 |
QIK |
0.871 | 0.018 | -3 | 0.851 |
CDKL5 |
0.871 | -0.017 | -3 | 0.776 |
QSK |
0.870 | 0.079 | 4 | 0.829 |
SIK |
0.870 | 0.072 | -3 | 0.767 |
NUAK1 |
0.870 | 0.033 | -3 | 0.795 |
IKKA |
0.870 | -0.046 | -2 | 0.805 |
CAMK4 |
0.868 | -0.042 | -3 | 0.835 |
PKACG |
0.868 | 0.005 | -2 | 0.773 |
ATM |
0.868 | 0.090 | 1 | 0.860 |
MNK2 |
0.867 | 0.053 | -2 | 0.837 |
GRK6 |
0.867 | -0.059 | 1 | 0.863 |
MASTL |
0.867 | -0.285 | -2 | 0.887 |
PAK6 |
0.867 | 0.112 | -2 | 0.757 |
IRE1 |
0.867 | -0.063 | 1 | 0.842 |
PAK3 |
0.867 | -0.013 | -2 | 0.833 |
CAMK2B |
0.867 | 0.061 | 2 | 0.786 |
CHK1 |
0.867 | 0.093 | -3 | 0.839 |
AURC |
0.867 | 0.070 | -2 | 0.676 |
SRPK1 |
0.866 | -0.000 | -3 | 0.720 |
FAM20C |
0.866 | 0.107 | 2 | 0.631 |
GRK1 |
0.866 | 0.009 | -2 | 0.831 |
ICK |
0.866 | -0.037 | -3 | 0.824 |
PAK1 |
0.866 | 0.007 | -2 | 0.825 |
NEK2 |
0.866 | -0.010 | 2 | 0.850 |
PKR |
0.865 | 0.050 | 1 | 0.889 |
ANKRD3 |
0.865 | -0.147 | 1 | 0.891 |
RIPK1 |
0.865 | -0.185 | 1 | 0.855 |
BRSK2 |
0.865 | -0.011 | -3 | 0.834 |
MLK3 |
0.864 | -0.004 | 2 | 0.779 |
BRSK1 |
0.864 | 0.012 | -3 | 0.791 |
MARK2 |
0.864 | 0.055 | 4 | 0.755 |
ALK4 |
0.864 | -0.005 | -2 | 0.863 |
CDK8 |
0.864 | -0.023 | 1 | 0.658 |
SMG1 |
0.864 | 0.090 | 1 | 0.865 |
PKCB |
0.863 | 0.047 | 2 | 0.775 |
IRE2 |
0.863 | -0.034 | 2 | 0.789 |
MARK3 |
0.863 | 0.056 | 4 | 0.786 |
TGFBR1 |
0.863 | 0.036 | -2 | 0.830 |
SRPK2 |
0.863 | 0.011 | -3 | 0.643 |
DLK |
0.863 | -0.223 | 1 | 0.859 |
PHKG1 |
0.862 | -0.032 | -3 | 0.830 |
PKCA |
0.862 | 0.043 | 2 | 0.771 |
DNAPK |
0.862 | 0.134 | 1 | 0.785 |
CAMK2A |
0.861 | 0.015 | 2 | 0.796 |
PKCG |
0.861 | 0.003 | 2 | 0.771 |
CHAK1 |
0.861 | -0.073 | 2 | 0.827 |
KIS |
0.860 | -0.039 | 1 | 0.676 |
PIM2 |
0.860 | 0.071 | -3 | 0.741 |
BMPR1B |
0.860 | 0.072 | 1 | 0.803 |
TTBK2 |
0.860 | -0.208 | 2 | 0.740 |
GRK4 |
0.860 | -0.181 | -2 | 0.856 |
MARK1 |
0.860 | 0.033 | 4 | 0.813 |
SSTK |
0.859 | 0.102 | 4 | 0.834 |
AURB |
0.859 | 0.036 | -2 | 0.677 |
PKCH |
0.859 | -0.002 | 2 | 0.766 |
MEK1 |
0.859 | -0.166 | 2 | 0.855 |
MSK2 |
0.859 | -0.069 | -3 | 0.726 |
VRK2 |
0.859 | -0.159 | 1 | 0.906 |
PKG2 |
0.859 | 0.042 | -2 | 0.698 |
LATS1 |
0.858 | -0.006 | -3 | 0.849 |
SGK3 |
0.858 | 0.042 | -3 | 0.762 |
CDK7 |
0.858 | -0.040 | 1 | 0.658 |
PAK2 |
0.858 | -0.051 | -2 | 0.816 |
PLK1 |
0.858 | -0.115 | -2 | 0.852 |
SNRK |
0.857 | -0.143 | 2 | 0.714 |
PKCZ |
0.857 | -0.034 | 2 | 0.816 |
CDK19 |
0.857 | -0.028 | 1 | 0.615 |
MNK1 |
0.857 | 0.018 | -2 | 0.851 |
RSK4 |
0.856 | 0.024 | -3 | 0.716 |
MYLK4 |
0.856 | -0.019 | -2 | 0.810 |
PKACB |
0.856 | 0.053 | -2 | 0.698 |
YSK4 |
0.856 | -0.142 | 1 | 0.791 |
PERK |
0.856 | -0.081 | -2 | 0.869 |
HRI |
0.855 | -0.114 | -2 | 0.887 |
ALK2 |
0.855 | 0.024 | -2 | 0.830 |
CLK1 |
0.855 | 0.034 | -3 | 0.746 |
CDK5 |
0.854 | 0.009 | 1 | 0.681 |
BRAF |
0.854 | -0.028 | -4 | 0.837 |
AKT2 |
0.854 | 0.023 | -3 | 0.672 |
WNK4 |
0.854 | -0.060 | -2 | 0.912 |
MLK4 |
0.854 | -0.101 | 2 | 0.748 |
CLK4 |
0.854 | 0.002 | -3 | 0.755 |
ACVR2A |
0.854 | -0.040 | -2 | 0.818 |
IRAK4 |
0.853 | -0.032 | 1 | 0.855 |
TLK2 |
0.853 | -0.074 | 1 | 0.865 |
SRPK3 |
0.853 | -0.049 | -3 | 0.687 |
MSK1 |
0.853 | -0.025 | -3 | 0.735 |
ACVR2B |
0.852 | -0.041 | -2 | 0.829 |
JNK2 |
0.852 | 0.030 | 1 | 0.587 |
MAPKAPK5 |
0.852 | -0.131 | -3 | 0.708 |
MPSK1 |
0.852 | 0.113 | 1 | 0.818 |
DCAMKL1 |
0.851 | -0.009 | -3 | 0.783 |
DYRK2 |
0.850 | -0.045 | 1 | 0.680 |
CAMK1G |
0.850 | -0.052 | -3 | 0.756 |
PLK3 |
0.850 | -0.125 | 2 | 0.771 |
PKCT |
0.849 | -0.005 | 2 | 0.777 |
JNK3 |
0.849 | -0.008 | 1 | 0.628 |
CAMK1D |
0.849 | 0.030 | -3 | 0.691 |
PRKX |
0.849 | 0.069 | -3 | 0.667 |
MEKK1 |
0.849 | -0.141 | 1 | 0.861 |
NEK5 |
0.849 | -0.052 | 1 | 0.881 |
P38A |
0.848 | -0.020 | 1 | 0.671 |
PHKG2 |
0.848 | -0.028 | -3 | 0.816 |
CDK13 |
0.848 | -0.075 | 1 | 0.626 |
ZAK |
0.848 | -0.123 | 1 | 0.816 |
P70S6K |
0.847 | -0.018 | -3 | 0.706 |
PINK1 |
0.847 | -0.169 | 1 | 0.853 |
SMMLCK |
0.847 | -0.036 | -3 | 0.820 |
AKT1 |
0.847 | 0.038 | -3 | 0.698 |
MEK5 |
0.846 | -0.275 | 2 | 0.852 |
TLK1 |
0.846 | -0.102 | -2 | 0.848 |
CDK18 |
0.846 | -0.024 | 1 | 0.578 |
MST3 |
0.846 | -0.004 | 2 | 0.854 |
BMPR1A |
0.846 | 0.052 | 1 | 0.797 |
PLK4 |
0.846 | -0.163 | 2 | 0.653 |
AURA |
0.845 | -0.019 | -2 | 0.643 |
HIPK1 |
0.845 | 0.000 | 1 | 0.699 |
CDK9 |
0.845 | -0.076 | 1 | 0.632 |
DCAMKL2 |
0.845 | -0.052 | -3 | 0.820 |
CAMKK1 |
0.845 | -0.077 | -2 | 0.827 |
GRK7 |
0.844 | -0.043 | 1 | 0.775 |
MEKK2 |
0.844 | -0.136 | 2 | 0.839 |
CDK2 |
0.844 | -0.078 | 1 | 0.692 |
PAK5 |
0.843 | 0.008 | -2 | 0.691 |
DRAK1 |
0.843 | -0.178 | 1 | 0.768 |
PKCI |
0.843 | -0.028 | 2 | 0.780 |
PKACA |
0.843 | 0.022 | -2 | 0.642 |
IRAK1 |
0.843 | -0.201 | -1 | 0.833 |
ERK2 |
0.842 | -0.069 | 1 | 0.636 |
HIPK3 |
0.842 | -0.034 | 1 | 0.695 |
CDK1 |
0.842 | -0.049 | 1 | 0.601 |
P38B |
0.842 | -0.020 | 1 | 0.587 |
PRP4 |
0.842 | -0.087 | -3 | 0.708 |
ERK1 |
0.842 | -0.040 | 1 | 0.580 |
HIPK2 |
0.841 | -0.004 | 1 | 0.584 |
LKB1 |
0.841 | -0.022 | -3 | 0.842 |
DYRK1A |
0.841 | -0.055 | 1 | 0.729 |
MEKK3 |
0.841 | -0.264 | 1 | 0.823 |
TAO2 |
0.840 | -0.054 | 2 | 0.881 |
TAO3 |
0.840 | -0.070 | 1 | 0.815 |
CAMKK2 |
0.840 | -0.079 | -2 | 0.822 |
GAK |
0.839 | 0.034 | 1 | 0.871 |
CDK12 |
0.839 | -0.084 | 1 | 0.595 |
NEK4 |
0.839 | -0.060 | 1 | 0.833 |
CDK17 |
0.839 | -0.051 | 1 | 0.519 |
P38G |
0.838 | -0.030 | 1 | 0.508 |
PKN1 |
0.838 | -0.026 | -3 | 0.730 |
CLK2 |
0.838 | 0.025 | -3 | 0.722 |
NEK8 |
0.838 | -0.162 | 2 | 0.849 |
PKCE |
0.838 | 0.016 | 2 | 0.761 |
TTBK1 |
0.837 | -0.200 | 2 | 0.655 |
CAMK1A |
0.837 | 0.027 | -3 | 0.650 |
PAK4 |
0.837 | 0.003 | -2 | 0.689 |
DAPK3 |
0.837 | 0.016 | -3 | 0.792 |
TNIK |
0.837 | 0.041 | 3 | 0.826 |
CK1E |
0.837 | -0.079 | -3 | 0.515 |
BUB1 |
0.837 | 0.145 | -5 | 0.858 |
EEF2K |
0.837 | -0.012 | 3 | 0.811 |
GRK2 |
0.837 | -0.174 | -2 | 0.731 |
HGK |
0.836 | -0.018 | 3 | 0.819 |
MEKK6 |
0.836 | -0.058 | 1 | 0.826 |
CDK14 |
0.836 | -0.039 | 1 | 0.626 |
TAK1 |
0.836 | -0.027 | 1 | 0.866 |
NEK1 |
0.836 | -0.000 | 1 | 0.847 |
CDK16 |
0.835 | 0.009 | 1 | 0.541 |
NEK11 |
0.835 | -0.220 | 1 | 0.813 |
MRCKB |
0.835 | 0.044 | -3 | 0.741 |
CHK2 |
0.834 | -0.018 | -3 | 0.628 |
MINK |
0.834 | -0.035 | 1 | 0.817 |
DYRK1B |
0.834 | -0.039 | 1 | 0.634 |
CDK3 |
0.834 | -0.010 | 1 | 0.539 |
MRCKA |
0.834 | 0.039 | -3 | 0.763 |
LOK |
0.834 | -0.018 | -2 | 0.844 |
CDK10 |
0.833 | -0.007 | 1 | 0.612 |
ROCK2 |
0.833 | 0.072 | -3 | 0.790 |
MAP3K15 |
0.833 | -0.078 | 1 | 0.793 |
PDK1 |
0.832 | -0.152 | 1 | 0.820 |
VRK1 |
0.832 | -0.074 | 2 | 0.851 |
GCK |
0.832 | -0.067 | 1 | 0.816 |
LRRK2 |
0.832 | -0.136 | 2 | 0.873 |
MST2 |
0.832 | -0.113 | 1 | 0.833 |
CK2A2 |
0.831 | 0.066 | 1 | 0.721 |
SGK1 |
0.831 | 0.018 | -3 | 0.588 |
ERK7 |
0.831 | -0.022 | 2 | 0.548 |
AKT3 |
0.831 | 0.013 | -3 | 0.602 |
PBK |
0.830 | 0.067 | 1 | 0.801 |
DYRK3 |
0.830 | -0.050 | 1 | 0.706 |
PASK |
0.830 | -0.158 | -3 | 0.830 |
P38D |
0.829 | -0.016 | 1 | 0.549 |
GSK3B |
0.829 | -0.099 | 4 | 0.406 |
DYRK4 |
0.829 | -0.050 | 1 | 0.597 |
YSK1 |
0.829 | -0.027 | 2 | 0.847 |
HPK1 |
0.828 | -0.063 | 1 | 0.789 |
KHS1 |
0.828 | 0.006 | 1 | 0.798 |
DAPK1 |
0.827 | -0.042 | -3 | 0.768 |
MEK2 |
0.827 | -0.208 | 2 | 0.841 |
CK1G1 |
0.827 | -0.131 | -3 | 0.508 |
SBK |
0.826 | -0.008 | -3 | 0.553 |
MST1 |
0.826 | -0.104 | 1 | 0.816 |
CK1D |
0.826 | -0.095 | -3 | 0.470 |
CDK6 |
0.825 | -0.038 | 1 | 0.607 |
KHS2 |
0.825 | 0.013 | 1 | 0.808 |
CDK4 |
0.825 | -0.042 | 1 | 0.584 |
RIPK2 |
0.824 | -0.272 | 1 | 0.766 |
NEK3 |
0.824 | -0.100 | 1 | 0.800 |
SLK |
0.823 | -0.104 | -2 | 0.789 |
MOK |
0.823 | 0.009 | 1 | 0.703 |
GSK3A |
0.822 | -0.089 | 4 | 0.416 |
DMPK1 |
0.822 | 0.064 | -3 | 0.758 |
CK1A2 |
0.822 | -0.105 | -3 | 0.466 |
BIKE |
0.821 | 0.115 | 1 | 0.750 |
PKG1 |
0.821 | -0.022 | -2 | 0.617 |
STK33 |
0.820 | -0.217 | 2 | 0.640 |
PDHK3_TYR |
0.820 | 0.130 | 4 | 0.904 |
ROCK1 |
0.820 | 0.035 | -3 | 0.758 |
CK2A1 |
0.819 | 0.023 | 1 | 0.694 |
GRK3 |
0.819 | -0.170 | -2 | 0.676 |
CRIK |
0.819 | 0.049 | -3 | 0.692 |
JNK1 |
0.819 | -0.066 | 1 | 0.575 |
MAK |
0.818 | 0.009 | -2 | 0.753 |
MYO3B |
0.816 | -0.008 | 2 | 0.861 |
PLK2 |
0.816 | -0.131 | -3 | 0.766 |
HASPIN |
0.815 | -0.001 | -1 | 0.714 |
TTK |
0.814 | -0.052 | -2 | 0.845 |
TESK1_TYR |
0.814 | -0.041 | 3 | 0.868 |
OSR1 |
0.813 | -0.101 | 2 | 0.826 |
MYO3A |
0.811 | -0.047 | 1 | 0.823 |
PKMYT1_TYR |
0.811 | -0.048 | 3 | 0.833 |
LIMK2_TYR |
0.810 | 0.040 | -3 | 0.911 |
ASK1 |
0.810 | -0.133 | 1 | 0.777 |
TAO1 |
0.809 | -0.099 | 1 | 0.751 |
MAP2K4_TYR |
0.808 | -0.177 | -1 | 0.920 |
PDHK4_TYR |
0.807 | -0.067 | 2 | 0.882 |
MAP2K7_TYR |
0.807 | -0.288 | 2 | 0.879 |
MAP2K6_TYR |
0.805 | -0.160 | -1 | 0.923 |
PINK1_TYR |
0.805 | -0.229 | 1 | 0.857 |
AAK1 |
0.805 | 0.148 | 1 | 0.639 |
ALPHAK3 |
0.803 | -0.115 | -1 | 0.801 |
TYK2 |
0.803 | -0.123 | 1 | 0.834 |
LIMK1_TYR |
0.802 | -0.161 | 2 | 0.887 |
BMPR2_TYR |
0.802 | -0.118 | -1 | 0.903 |
PDHK1_TYR |
0.802 | -0.169 | -1 | 0.932 |
RET |
0.802 | -0.121 | 1 | 0.833 |
EPHA6 |
0.801 | -0.011 | -1 | 0.905 |
ROS1 |
0.801 | -0.095 | 3 | 0.748 |
TYRO3 |
0.799 | -0.129 | 3 | 0.769 |
EPHB4 |
0.799 | -0.044 | -1 | 0.900 |
STLK3 |
0.799 | -0.185 | 1 | 0.780 |
JAK2 |
0.798 | -0.155 | 1 | 0.828 |
TNNI3K_TYR |
0.797 | 0.045 | 1 | 0.863 |
MST1R |
0.797 | -0.190 | 3 | 0.771 |
TXK |
0.797 | 0.061 | 1 | 0.855 |
DDR1 |
0.796 | -0.176 | 4 | 0.842 |
ABL2 |
0.795 | -0.039 | -1 | 0.878 |
YES1 |
0.794 | -0.056 | -1 | 0.903 |
FGR |
0.793 | -0.116 | 1 | 0.874 |
FER |
0.793 | -0.157 | 1 | 0.902 |
HCK |
0.792 | -0.063 | -1 | 0.895 |
ITK |
0.792 | -0.043 | -1 | 0.880 |
CSF1R |
0.792 | -0.186 | 3 | 0.749 |
TNK2 |
0.792 | -0.089 | 3 | 0.695 |
LCK |
0.791 | 0.006 | -1 | 0.889 |
TNK1 |
0.791 | -0.088 | 3 | 0.757 |
ABL1 |
0.790 | -0.075 | -1 | 0.873 |
NEK10_TYR |
0.790 | -0.103 | 1 | 0.682 |
PDGFRB |
0.790 | -0.170 | 3 | 0.770 |
EPHB1 |
0.790 | -0.097 | 1 | 0.869 |
EPHB3 |
0.790 | -0.074 | -1 | 0.895 |
JAK3 |
0.789 | -0.189 | 1 | 0.811 |
SRMS |
0.788 | -0.117 | 1 | 0.874 |
JAK1 |
0.788 | -0.075 | 1 | 0.771 |
EPHB2 |
0.788 | -0.063 | -1 | 0.884 |
EPHA4 |
0.787 | -0.103 | 2 | 0.760 |
YANK3 |
0.787 | -0.167 | 2 | 0.400 |
BLK |
0.787 | 0.008 | -1 | 0.898 |
INSRR |
0.786 | -0.197 | 3 | 0.714 |
AXL |
0.786 | -0.147 | 3 | 0.731 |
BTK |
0.786 | -0.148 | -1 | 0.855 |
FLT3 |
0.785 | -0.194 | 3 | 0.759 |
PTK6 |
0.785 | -0.154 | -1 | 0.801 |
TEC |
0.785 | -0.061 | -1 | 0.825 |
TEK |
0.785 | -0.197 | 3 | 0.700 |
PDGFRA |
0.784 | -0.235 | 3 | 0.765 |
MERTK |
0.783 | -0.138 | 3 | 0.735 |
BMX |
0.782 | -0.084 | -1 | 0.784 |
CK1A |
0.782 | -0.151 | -3 | 0.373 |
FGFR2 |
0.781 | -0.282 | 3 | 0.748 |
KDR |
0.780 | -0.212 | 3 | 0.711 |
ALK |
0.780 | -0.195 | 3 | 0.685 |
FGFR1 |
0.780 | -0.258 | 3 | 0.730 |
WEE1_TYR |
0.780 | -0.153 | -1 | 0.804 |
KIT |
0.780 | -0.259 | 3 | 0.751 |
EPHA1 |
0.779 | -0.142 | 3 | 0.707 |
LTK |
0.778 | -0.191 | 3 | 0.710 |
EPHA7 |
0.778 | -0.119 | 2 | 0.770 |
LYN |
0.776 | -0.111 | 3 | 0.689 |
FYN |
0.776 | -0.056 | -1 | 0.856 |
FRK |
0.776 | -0.145 | -1 | 0.913 |
EPHA3 |
0.775 | -0.198 | 2 | 0.741 |
MET |
0.774 | -0.235 | 3 | 0.733 |
NTRK1 |
0.773 | -0.310 | -1 | 0.873 |
DDR2 |
0.773 | -0.105 | 3 | 0.681 |
NTRK2 |
0.773 | -0.285 | 3 | 0.716 |
ERBB2 |
0.771 | -0.275 | 1 | 0.784 |
PTK2B |
0.770 | -0.127 | -1 | 0.854 |
INSR |
0.770 | -0.264 | 3 | 0.693 |
FLT4 |
0.769 | -0.284 | 3 | 0.717 |
FLT1 |
0.768 | -0.262 | -1 | 0.872 |
EPHA5 |
0.768 | -0.156 | 2 | 0.746 |
SRC |
0.767 | -0.134 | -1 | 0.860 |
NTRK3 |
0.766 | -0.265 | -1 | 0.821 |
FGFR3 |
0.765 | -0.329 | 3 | 0.718 |
EPHA8 |
0.765 | -0.177 | -1 | 0.870 |
CK1G3 |
0.763 | -0.150 | -3 | 0.321 |
MATK |
0.760 | -0.257 | -1 | 0.789 |
CSK |
0.760 | -0.266 | 2 | 0.778 |
MUSK |
0.760 | -0.199 | 1 | 0.670 |
EGFR |
0.759 | -0.189 | 1 | 0.691 |
YANK2 |
0.752 | -0.205 | 2 | 0.421 |
PTK2 |
0.752 | -0.137 | -1 | 0.804 |
FGFR4 |
0.752 | -0.269 | -1 | 0.815 |
EPHA2 |
0.751 | -0.211 | -1 | 0.825 |
SYK |
0.751 | -0.141 | -1 | 0.800 |
IGF1R |
0.750 | -0.290 | 3 | 0.640 |
ERBB4 |
0.745 | -0.183 | 1 | 0.706 |
FES |
0.738 | -0.271 | -1 | 0.759 |
CK1G2 |
0.732 | -0.193 | -3 | 0.421 |
ZAP70 |
0.722 | -0.198 | -1 | 0.717 |