Motif 760 (n=138)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| H0YHG0 | None | S475 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| O00148 | DDX39A | S185 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O14523 | C2CD2L | S674 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14974 | PPP1R12A | S292 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15258 | RER1 | S100 | ochoa | Protein RER1 | Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}. |
| O15360 | FANCA | S695 | ochoa | Fanconi anemia group A protein (Protein FACA) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
| O15439 | ABCC4 | S404 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O15446 | POLR1G | S172 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O43707 | ACTN4 | S507 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60244 | MED14 | S625 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60331 | PIP5K1C | S453 | ochoa|psp | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12422219, ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:22942276, ECO:0000305|PubMed:19889969}. |
| O60841 | EIF5B | S438 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O95049 | TJP3 | S212 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95239 | KIF4A | S886 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95425 | SVIL | S1168 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95789 | ZMYM6 | S730 | ochoa | Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| O95983 | MBD3 | S37 | ochoa | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| P05549 | TFAP2A | S222 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P07900 | HSP90AA1 | S72 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08195 | SLC3A2 | S296 | ochoa | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P08238 | HSP90AB1 | S67 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10275 | AR | S579 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P14618 | PKM | S333 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P16949 | STMN1 | S38 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P17480 | UBTF | S449 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P20273 | CD22 | S797 | ochoa | B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) | Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration (PubMed:20172905). Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling (PubMed:8627166). If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced (PubMed:20516366). {ECO:0000269|PubMed:20172905, ECO:0000269|PubMed:20516366, ECO:0000269|PubMed:34330755, ECO:0000269|PubMed:8627166}. |
| P22314 | UBA1 | S816 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P29401 | TKT | S190 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P32519 | ELF1 | S195 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P35251 | RFC1 | S139 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35611 | ADD1 | S716 | psp | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P35612 | ADD2 | S703 | ochoa|psp | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P39687 | ANP32A | S96 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| P45378 | TNNT3 | S167 | ochoa | Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT) | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P48165 | GJA8 | S259 | psp | Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70) | Structural component of eye lens gap junctions (PubMed:18006672, PubMed:19756179). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:18006672, PubMed:19756179). {ECO:0000250|UniProtKB:P55917, ECO:0000269|PubMed:16397066, ECO:0000269|PubMed:18006672, ECO:0000269|PubMed:19756179, ECO:0000269|PubMed:35531093}. |
| P49327 | FASN | S1481 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49756 | RBM25 | S683 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P51825 | AFF1 | S667 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52565 | ARHGDIA | S96 | psp | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P55210 | CASP7 | S37 | ochoa | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:15314233, PubMed:17697120, PubMed:19581639, PubMed:20566630, PubMed:23650375, PubMed:23897474, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:27889207, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}. |
| P62910 | RPL32 | S62 | ochoa | Large ribosomal subunit protein eL32 (60S ribosomal protein L32) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P62913 | RPL11 | S140 | ochoa | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}. |
| P78345 | RPP38 | S240 | ochoa | Ribonuclease P protein subunit p38 (RNaseP protein p38) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}. |
| P78559 | MAP1A | S322 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82979 | SARNP | S162 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| P98082 | DAB2 | S24 | ochoa|psp | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| P98175 | RBM10 | S207 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q02880 | TOP2B | S1212 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q06710 | PAX8 | S217 | ochoa | Paired box protein Pax-8 | Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. |
| Q07020 | RPL18 | S130 | ochoa | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q12983 | BNIP3 | S149 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q13029 | PRDM2 | S876 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13185 | CBX3 | S102 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13415 | ORC1 | S350 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13523 | PRP4K | S622 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14694 | USP10 | S718 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14980 | NUMA1 | S83 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | S558 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | S1438 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15032 | R3HDM1 | S187 | ochoa | R3H domain-containing protein 1 | None |
| Q1ED39 | KNOP1 | S185 | ochoa | Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein) | None |
| Q2M389 | WASHC4 | S1097 | ochoa | WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000303|PubMed:21498477}. |
| Q49A26 | GLYR1 | S223 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q58FF7 | HSP90AB3P | S67 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | S67 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5FWF5 | ESCO1 | S384 | ochoa | N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}. |
| Q5UIP0 | RIF1 | S2352 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5XPI4 | RNF123 | S19 | ochoa | E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) | Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase (PubMed:15531880, PubMed:16227581, PubMed:25860612). Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit (PubMed:25860612, PubMed:33168738, PubMed:34873064). Also functions as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612, ECO:0000269|PubMed:27312109, ECO:0000269|PubMed:33168738, ECO:0000269|PubMed:34873064}. |
| Q6NW29 | RWDD4 | S139 | ochoa | RWD domain-containing protein 4 (Protein FAM28A) | None |
| Q6P0N0 | MIS18BP1 | S739 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6Q0C0 | TRAF7 | S317 | ochoa | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). {ECO:0000250|UniProtKB:Q922B6, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:29961569, ECO:0000269|PubMed:37086853}. |
| Q6VUC0 | TFAP2E | S229 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
| Q6ZU52 | KIAA0408 | S246 | ochoa | Uncharacterized protein KIAA0408 | None |
| Q6ZV73 | FGD6 | S700 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7L2Z9 | CENPQ | S249 | ochoa|psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q7Z6E9 | RBBP6 | S1179 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6R9 | TFAP2D | S222 | ochoa | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}. |
| Q86WJ1 | CHD1L | S628 | ochoa | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34210977, PubMed:34486521, PubMed:34874266). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888). {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220652, ECO:0000269|PubMed:29220653, ECO:0000269|PubMed:33275888, ECO:0000269|PubMed:33357431, ECO:0000269|PubMed:34210977, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. |
| Q8IWC1 | MAP7D3 | S556 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IWZ3 | ANKHD1 | S1632 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IZT6 | ASPM | S612 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N157 | AHI1 | S232 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8N4N8 | KIF2B | S643 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N4X5 | AFAP1L2 | S224 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N9B5 | JMY | S870 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NC26 | ZNF114 | S291 | ochoa | Zinc finger protein 114 | May be involved in transcriptional regulation. |
| Q8NCF5 | NFATC2IP | S204 | ochoa|psp | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8TF76 | HASPIN | S389 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q92481 | TFAP2B | S241 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
| Q92688 | ANP32B | S96 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| Q92754 | TFAP2C | S235 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
| Q92785 | DPF2 | S280 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92800 | EZH1 | S490 | ochoa | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}. |
| Q93045 | STMN2 | S73 | psp | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q96AA8 | JAKMIP2 | S42 | ochoa | Janus kinase and microtubule-interacting protein 2 (CTCL tumor antigen HD-CL-04) (Neuroendocrine long coiled-coil protein 1) | None |
| Q96DN5 | TBC1D31 | S902 | ochoa | TBC1 domain family member 31 (WD repeat-containing protein 67) | Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation. {ECO:0000269|PubMed:33934390}. |
| Q96IZ0 | PAWR | S266 | ochoa | PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. |
| Q96JJ3 | ELMO2 | S336 | ochoa | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:11703939, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:27476657}. |
| Q96JM3 | CHAMP1 | S603 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S616 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96MU7 | YTHDC1 | S545 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96NB3 | ZNF830 | S100 | ochoa | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). {ECO:0000250|UniProtKB:Q8R1N0, ECO:0000305|PubMed:25599396}. |
| Q96PY5 | FMNL2 | S678 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96T60 | PNKP | S126 | psp | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785}. |
| Q96T68 | SETDB2 | S318 | ochoa | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}. |
| Q99549 | MPHOSPH8 | S149 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9BQG0 | MYBBP1A | S1166 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BS16 | CENPK | S194 | ochoa | Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}. |
| Q9BSC4 | NOL10 | S514 | ochoa | Nucleolar protein 10 | None |
| Q9H2P0 | ADNP | S805 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H410 | DSN1 | S57 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H4A5 | GOLPH3L | S110 | ochoa | Golgi phosphoprotein 3-like (GPP34-related protein) | Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}. |
| Q9H4Z2 | ZNF335 | S645 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H9P5 | UNKL | S327 | ochoa | Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) | May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. {ECO:0000269|PubMed:20148946}. |
| Q9HAV4 | XPO5 | S1137 | ochoa | Exportin-5 (Exp5) (Ran-binding protein 21) | Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.; FUNCTION: Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14631048, PubMed:14681208, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479). {ECO:0000269|PubMed:14631048, ECO:0000269|PubMed:14681208, ECO:0000269|PubMed:15613540, ECO:0000269|PubMed:19965479}.; FUNCTION: (Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA. {ECO:0000269|PubMed:12509441}. |
| Q9HB71 | CACYBP | S142 | ochoa | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
| Q9HD64 | XAGE1A | S20 | ochoa | X antigen family member 1 (XAGE-1) (Cancer/testis antigen 12.1) (CT12.1) (G antigen family D member 2) | None |
| Q9NR09 | BIRC6 | S547 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NRS6 | SNX15 | S116 | ochoa | Sorting nexin-15 | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}. |
| Q9NZ72 | STMN3 | S73 | ochoa|psp | Stathmin-3 (SCG10-like protein) | Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}. |
| Q9NZZ3 | CHMP5 | S30 | ochoa | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}. |
| Q9UBB5 | MBD2 | S181 | ochoa | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| Q9UIS9 | MBD1 | S37 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UNL4 | ING4 | S126 | ochoa | Inhibitor of growth protein 4 (p29ING4) | Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}. |
| Q9Y230 | RUVBL2 | S220 | ochoa | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| Q9Y2Y9 | KLF13 | S162 | ochoa | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y490 | TLN1 | S52 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4E5 | ZNF451 | S838 | ochoa | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. |
| P17948 | FLT1 | S1031 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| O14929 | HAT1 | S361 | Sugiyama | Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) | Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:23653357, ECO:0000269|PubMed:31278053, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:32081014}.; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. {ECO:0000269|PubMed:31695772}. |
| Q9BWD1 | ACAT2 | S208 | Sugiyama | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase) | Involved in the biosynthetic pathway of cholesterol. {ECO:0000303|PubMed:15733928}. |
| P35916 | FLT4 | S1046 | Sugiyama | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| Q99961 | SH3GL1 | S108 | Sugiyama | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
| Q04759 | PRKCQ | S370 | Sugiyama | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| Q13043 | STK4 | S423 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q8IWI9 | MGA | S870 | Sugiyama | MAX gene-associated protein (MAX dimerization protein 5) | Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity). {ECO:0000250|UniProtKB:A2AWL7}. |
| Q8TF76 | HASPIN | S353 | Sugiyama | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| P43034 | PAFAH1B1 | S161 | Sugiyama | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.967787e-09 | 8.706 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.712501e-07 | 6.766 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.571240e-05 | 4.804 |
| R-HSA-9834899 | Specification of the neural plate border | 1.077874e-04 | 3.967 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 1.936376e-04 | 3.713 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 1.186962e-03 | 2.926 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.275211e-03 | 2.894 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 9.582514e-04 | 3.019 |
| R-HSA-373755 | Semaphorin interactions | 7.763822e-04 | 3.110 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 1.698129e-03 | 2.770 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.623946e-03 | 2.789 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.798107e-03 | 2.745 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.633817e-03 | 2.579 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.633817e-03 | 2.579 |
| R-HSA-73886 | Chromosome Maintenance | 2.456993e-03 | 2.610 |
| R-HSA-1640170 | Cell Cycle | 2.613641e-03 | 2.583 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.309548e-03 | 2.636 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 2.979870e-03 | 2.526 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 2.979870e-03 | 2.526 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.281472e-03 | 2.138 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.291129e-03 | 2.276 |
| R-HSA-68877 | Mitotic Prometaphase | 5.582192e-03 | 2.253 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 6.532884e-03 | 2.185 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 7.617562e-03 | 2.118 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 6.683552e-03 | 2.175 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 4.595952e-03 | 2.338 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 6.532884e-03 | 2.185 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 7.617562e-03 | 2.118 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.530808e-03 | 2.123 |
| R-HSA-9758941 | Gastrulation | 6.811044e-03 | 2.167 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.691373e-03 | 2.114 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 8.315077e-03 | 2.080 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 8.678234e-03 | 2.062 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 8.777573e-03 | 2.057 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.001134e-02 | 2.000 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.004810e-02 | 1.998 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.004810e-02 | 1.998 |
| R-HSA-422475 | Axon guidance | 1.136743e-02 | 1.944 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.167062e-02 | 1.933 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.269395e-02 | 1.896 |
| R-HSA-194138 | Signaling by VEGF | 1.346306e-02 | 1.871 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.397096e-02 | 1.855 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.967714e-02 | 1.706 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.967714e-02 | 1.706 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.967714e-02 | 1.706 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.967714e-02 | 1.706 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.967714e-02 | 1.706 |
| R-HSA-774815 | Nucleosome assembly | 1.628708e-02 | 1.788 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.628708e-02 | 1.788 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.822103e-02 | 1.739 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.881894e-02 | 1.725 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.133171e-02 | 1.671 |
| R-HSA-156902 | Peptide chain elongation | 1.649895e-02 | 1.783 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.199046e-02 | 1.658 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.058530e-02 | 1.686 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.199046e-02 | 1.658 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.199046e-02 | 1.658 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.942891e-02 | 1.712 |
| R-HSA-75153 | Apoptotic execution phase | 1.710408e-02 | 1.767 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.723296e-02 | 1.764 |
| R-HSA-9675108 | Nervous system development | 1.781668e-02 | 1.749 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.540991e-02 | 1.812 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.881894e-02 | 1.725 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.235511e-02 | 1.651 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.248132e-02 | 1.648 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.620368e-02 | 1.582 |
| R-HSA-192823 | Viral mRNA Translation | 2.770843e-02 | 1.557 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.896945e-02 | 1.409 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.896945e-02 | 1.409 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.896945e-02 | 1.409 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.896945e-02 | 1.409 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.896945e-02 | 1.409 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.896945e-02 | 1.409 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.896945e-02 | 1.409 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.896945e-02 | 1.409 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.896945e-02 | 1.409 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.896945e-02 | 1.409 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.896945e-02 | 1.409 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.169251e-02 | 1.499 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.599658e-02 | 1.444 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.599658e-02 | 1.444 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 3.896945e-02 | 1.409 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.252764e-02 | 1.488 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.847979e-02 | 1.545 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.610585e-02 | 1.442 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.802268e-02 | 1.552 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.003267e-02 | 1.522 |
| R-HSA-9830364 | Formation of the nephric duct | 3.858348e-02 | 1.414 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.252764e-02 | 1.488 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.079610e-02 | 1.389 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.131777e-02 | 1.384 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.316861e-02 | 1.365 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.316861e-02 | 1.365 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.348522e-02 | 1.362 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.486230e-02 | 1.348 |
| R-HSA-209563 | Axonal growth stimulation | 4.847365e-02 | 1.314 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 4.847365e-02 | 1.314 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.794547e-02 | 1.319 |
| R-HSA-69275 | G2/M Transition | 5.486571e-02 | 1.261 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.672031e-02 | 1.246 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.672031e-02 | 1.246 |
| R-HSA-74160 | Gene expression (Transcription) | 5.756936e-02 | 1.240 |
| R-HSA-4839726 | Chromatin organization | 5.303334e-02 | 1.275 |
| R-HSA-168255 | Influenza Infection | 4.865694e-02 | 1.313 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.821076e-02 | 1.235 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.021538e-02 | 1.220 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 6.066668e-02 | 1.217 |
| R-HSA-5696400 | Dual Incision in GG-NER | 6.333572e-02 | 1.198 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.320806e-02 | 1.135 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.675353e-02 | 1.115 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 8.305847e-02 | 1.081 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.985078e-02 | 1.156 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 8.013645e-02 | 1.096 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 6.720272e-02 | 1.173 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.642941e-02 | 1.117 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 8.305847e-02 | 1.081 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 6.720272e-02 | 1.173 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 7.642941e-02 | 1.117 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 7.642941e-02 | 1.117 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.912697e-02 | 1.102 |
| R-HSA-3371511 | HSF1 activation | 6.879016e-02 | 1.162 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.467906e-02 | 1.189 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 6.720272e-02 | 1.173 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 7.724765e-02 | 1.112 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 7.642941e-02 | 1.117 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 8.305847e-02 | 1.081 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 6.720272e-02 | 1.173 |
| R-HSA-3371568 | Attenuation phase | 8.013645e-02 | 1.096 |
| R-HSA-69205 | G1/S-Specific Transcription | 6.879016e-02 | 1.162 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 8.013645e-02 | 1.096 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.114520e-02 | 1.148 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 7.724765e-02 | 1.112 |
| R-HSA-8953854 | Metabolism of RNA | 8.546010e-02 | 1.068 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.556540e-02 | 1.068 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 8.556540e-02 | 1.068 |
| R-HSA-73894 | DNA Repair | 8.617982e-02 | 1.065 |
| R-HSA-68882 | Mitotic Anaphase | 8.760744e-02 | 1.057 |
| R-HSA-196025 | Formation of annular gap junctions | 1.035688e-01 | 0.985 |
| R-HSA-190873 | Gap junction degradation | 1.124380e-01 | 0.949 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.124380e-01 | 0.949 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.470511e-01 | 0.833 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.803224e-01 | 0.744 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.803224e-01 | 0.744 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.884367e-01 | 0.725 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.964712e-01 | 0.707 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.964712e-01 | 0.707 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.964712e-01 | 0.707 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.044266e-01 | 0.689 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.201034e-01 | 0.657 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.278263e-01 | 0.642 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.278263e-01 | 0.642 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.354732e-01 | 0.628 |
| R-HSA-72187 | mRNA 3'-end processing | 1.203908e-01 | 0.919 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.236655e-01 | 0.908 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.336155e-01 | 0.874 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.403467e-01 | 0.853 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.471496e-01 | 0.832 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.574769e-01 | 0.803 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.574769e-01 | 0.803 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.679360e-01 | 0.775 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.927629e-01 | 0.715 |
| R-HSA-380287 | Centrosome maturation | 1.999445e-01 | 0.699 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.633366e-01 | 0.787 |
| R-HSA-73893 | DNA Damage Bypass | 1.107035e-01 | 0.956 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.579652e-01 | 0.588 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.721275e-01 | 0.764 |
| R-HSA-69091 | Polymerase switching | 1.470511e-01 | 0.833 |
| R-HSA-69109 | Leading Strand Synthesis | 1.470511e-01 | 0.833 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.123038e-01 | 0.673 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.999445e-01 | 0.699 |
| R-HSA-72172 | mRNA Splicing | 1.846352e-01 | 0.734 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 9.461158e-02 | 1.024 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.832491e-01 | 0.737 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.118400e-01 | 0.951 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.035765e-01 | 0.985 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.124380e-01 | 0.949 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.325951e-01 | 0.633 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.160408e-01 | 0.665 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.124380e-01 | 0.949 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.212200e-01 | 0.916 |
| R-HSA-192905 | vRNP Assembly | 1.299156e-01 | 0.886 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.470511e-01 | 0.833 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.653154e-01 | 0.576 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.927629e-01 | 0.715 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.044266e-01 | 0.689 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.638512e-01 | 0.786 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.721275e-01 | 0.764 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.035688e-01 | 0.985 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.579652e-01 | 0.588 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.653154e-01 | 0.576 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.653154e-01 | 0.576 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.124380e-01 | 0.949 |
| R-HSA-983189 | Kinesins | 1.471496e-01 | 0.832 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.278263e-01 | 0.642 |
| R-HSA-114608 | Platelet degranulation | 1.685098e-01 | 0.773 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.044266e-01 | 0.689 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 9.813502e-02 | 1.008 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.721275e-01 | 0.764 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.123038e-01 | 0.673 |
| R-HSA-190828 | Gap junction trafficking | 9.506050e-02 | 1.022 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.171384e-01 | 0.931 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.653154e-01 | 0.576 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.505763e-01 | 0.822 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.380438e-01 | 0.860 |
| R-HSA-157579 | Telomere Maintenance | 9.360916e-02 | 1.029 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.123038e-01 | 0.673 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.831825e-01 | 0.737 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.856609e-01 | 0.731 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.107035e-01 | 0.956 |
| R-HSA-2028269 | Signaling by Hippo | 1.964712e-01 | 0.707 |
| R-HSA-3214847 | HATs acetylate histones | 9.754645e-02 | 1.011 |
| R-HSA-3928664 | Ephrin signaling | 2.044266e-01 | 0.689 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.201034e-01 | 0.657 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.083437e-01 | 0.681 |
| R-HSA-69242 | S Phase | 2.289994e-01 | 0.640 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.180276e-01 | 0.661 |
| R-HSA-189085 | Digestion of dietary carbohydrate | 2.354732e-01 | 0.628 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.354732e-01 | 0.628 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.253023e-01 | 0.647 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.212200e-01 | 0.916 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.044266e-01 | 0.689 |
| R-HSA-180786 | Extension of Telomeres | 1.437396e-01 | 0.842 |
| R-HSA-9711097 | Cellular response to starvation | 9.954531e-02 | 1.002 |
| R-HSA-68886 | M Phase | 1.084626e-01 | 0.965 |
| R-HSA-73884 | Base Excision Repair | 2.582133e-01 | 0.588 |
| R-HSA-210991 | Basigin interactions | 2.278263e-01 | 0.642 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.540189e-01 | 0.812 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.963495e-01 | 0.707 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.053462e-02 | 1.043 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.471496e-01 | 0.832 |
| R-HSA-72312 | rRNA processing | 1.077548e-01 | 0.968 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.254903e-01 | 0.901 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.254903e-01 | 0.901 |
| R-HSA-109581 | Apoptosis | 2.659758e-01 | 0.575 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.385257e-01 | 0.858 |
| R-HSA-373753 | Nephrin family interactions | 2.201034e-01 | 0.657 |
| R-HSA-5357801 | Programmed Cell Death | 1.866157e-01 | 0.729 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.104213e-01 | 0.957 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.653154e-01 | 0.576 |
| R-HSA-70268 | Pyruvate metabolism | 2.472212e-01 | 0.607 |
| R-HSA-1266738 | Developmental Biology | 1.694517e-01 | 0.771 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.671400e-01 | 0.777 |
| R-HSA-2262752 | Cellular responses to stress | 2.343215e-01 | 0.630 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.749740e-01 | 0.757 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.089567e-01 | 0.963 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.880363e-02 | 1.052 |
| R-HSA-418990 | Adherens junctions interactions | 2.129603e-01 | 0.672 |
| R-HSA-163685 | Integration of energy metabolism | 1.956615e-01 | 0.708 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.342242e-01 | 0.630 |
| R-HSA-8964038 | LDL clearance | 2.430448e-01 | 0.614 |
| R-HSA-1500931 | Cell-Cell communication | 2.431603e-01 | 0.614 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.574769e-01 | 0.803 |
| R-HSA-9830369 | Kidney development | 1.714489e-01 | 0.766 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.963495e-01 | 0.707 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.143982e-01 | 0.669 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.071576e-01 | 0.684 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.806956e-01 | 0.743 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.981825e-01 | 0.703 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.203908e-01 | 0.919 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.692130e-01 | 0.570 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.700355e-01 | 0.569 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.725933e-01 | 0.564 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.725933e-01 | 0.564 |
| R-HSA-70635 | Urea cycle | 2.725933e-01 | 0.564 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.797995e-01 | 0.553 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.797995e-01 | 0.553 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.797995e-01 | 0.553 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.797995e-01 | 0.553 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.802104e-01 | 0.553 |
| R-HSA-421270 | Cell-cell junction organization | 2.837087e-01 | 0.547 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.869348e-01 | 0.542 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.869348e-01 | 0.542 |
| R-HSA-622312 | Inflammasomes | 2.869348e-01 | 0.542 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.869348e-01 | 0.542 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.869348e-01 | 0.542 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.875361e-01 | 0.541 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.939998e-01 | 0.532 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.939998e-01 | 0.532 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.961122e-01 | 0.529 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.982107e-01 | 0.525 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.009101e-01 | 0.522 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.009953e-01 | 0.521 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.009953e-01 | 0.521 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.009953e-01 | 0.521 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.009953e-01 | 0.521 |
| R-HSA-70171 | Glycolysis | 3.021616e-01 | 0.520 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.079218e-01 | 0.512 |
| R-HSA-182971 | EGFR downregulation | 3.079218e-01 | 0.512 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.103317e-01 | 0.508 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.147802e-01 | 0.502 |
| R-HSA-69190 | DNA strand elongation | 3.147802e-01 | 0.502 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.167365e-01 | 0.499 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.167365e-01 | 0.499 |
| R-HSA-354192 | Integrin signaling | 3.215710e-01 | 0.493 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.215710e-01 | 0.493 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.215710e-01 | 0.493 |
| R-HSA-9930044 | Nuclear RNA decay | 3.215710e-01 | 0.493 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.215710e-01 | 0.493 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.215710e-01 | 0.493 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.215710e-01 | 0.493 |
| R-HSA-390522 | Striated Muscle Contraction | 3.282949e-01 | 0.484 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.282949e-01 | 0.484 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.282949e-01 | 0.484 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.282949e-01 | 0.484 |
| R-HSA-69239 | Synthesis of DNA | 3.312424e-01 | 0.480 |
| R-HSA-211000 | Gene Silencing by RNA | 3.312424e-01 | 0.480 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.349489e-01 | 0.475 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.349526e-01 | 0.475 |
| R-HSA-203615 | eNOS activation | 3.349526e-01 | 0.475 |
| R-HSA-190861 | Gap junction assembly | 3.349526e-01 | 0.475 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.435477e-01 | 0.464 |
| R-HSA-446728 | Cell junction organization | 3.439289e-01 | 0.464 |
| R-HSA-5617833 | Cilium Assembly | 3.441876e-01 | 0.463 |
| R-HSA-199991 | Membrane Trafficking | 3.477384e-01 | 0.459 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.480719e-01 | 0.458 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.545348e-01 | 0.450 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.545348e-01 | 0.450 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.564125e-01 | 0.448 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.609340e-01 | 0.443 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.609340e-01 | 0.443 |
| R-HSA-71336 | Pentose phosphate pathway | 3.672702e-01 | 0.435 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.672702e-01 | 0.435 |
| R-HSA-9648002 | RAS processing | 3.672702e-01 | 0.435 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.672702e-01 | 0.435 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.711629e-01 | 0.430 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.735439e-01 | 0.428 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.735439e-01 | 0.428 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.735439e-01 | 0.428 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.735439e-01 | 0.428 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.735439e-01 | 0.428 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.735439e-01 | 0.428 |
| R-HSA-167169 | HIV Transcription Elongation | 3.735439e-01 | 0.428 |
| R-HSA-9646399 | Aggrephagy | 3.735439e-01 | 0.428 |
| R-HSA-71240 | Tryptophan catabolism | 3.735439e-01 | 0.428 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.739541e-01 | 0.427 |
| R-HSA-70326 | Glucose metabolism | 3.741865e-01 | 0.427 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.797558e-01 | 0.420 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.797558e-01 | 0.420 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.859065e-01 | 0.414 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.859065e-01 | 0.414 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.859065e-01 | 0.414 |
| R-HSA-3371556 | Cellular response to heat stress | 3.882633e-01 | 0.411 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.882633e-01 | 0.411 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.952502e-01 | 0.403 |
| R-HSA-212436 | Generic Transcription Pathway | 3.952994e-01 | 0.403 |
| R-HSA-373752 | Netrin-1 signaling | 4.039972e-01 | 0.394 |
| R-HSA-69206 | G1/S Transition | 4.056622e-01 | 0.392 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.099090e-01 | 0.387 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.099090e-01 | 0.387 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.157625e-01 | 0.381 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.157625e-01 | 0.381 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.157625e-01 | 0.381 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.157625e-01 | 0.381 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.157625e-01 | 0.381 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.157625e-01 | 0.381 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.157625e-01 | 0.381 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.157625e-01 | 0.381 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.157625e-01 | 0.381 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.215582e-01 | 0.375 |
| R-HSA-437239 | Recycling pathway of L1 | 4.215582e-01 | 0.375 |
| R-HSA-1474165 | Reproduction | 4.262252e-01 | 0.370 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.272969e-01 | 0.369 |
| R-HSA-9843745 | Adipogenesis | 4.296169e-01 | 0.367 |
| R-HSA-9748787 | Azathioprine ADME | 4.386050e-01 | 0.358 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.413442e-01 | 0.355 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.426978e-01 | 0.354 |
| R-HSA-2514856 | The phototransduction cascade | 4.441755e-01 | 0.352 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.496912e-01 | 0.347 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.496912e-01 | 0.347 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.497423e-01 | 0.347 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.551524e-01 | 0.342 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.551524e-01 | 0.342 |
| R-HSA-72766 | Translation | 4.636929e-01 | 0.334 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.659138e-01 | 0.332 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.659138e-01 | 0.332 |
| R-HSA-418597 | G alpha (z) signalling events | 4.659138e-01 | 0.332 |
| R-HSA-9753281 | Paracetamol ADME | 4.659138e-01 | 0.332 |
| R-HSA-177929 | Signaling by EGFR | 4.712150e-01 | 0.327 |
| R-HSA-8935690 | Digestion | 4.712150e-01 | 0.327 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.712150e-01 | 0.327 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.727115e-01 | 0.325 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.727115e-01 | 0.325 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.855779e-01 | 0.314 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.868070e-01 | 0.313 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.919021e-01 | 0.308 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.919021e-01 | 0.308 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.982494e-01 | 0.303 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.013864e-01 | 0.300 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.019420e-01 | 0.299 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.019420e-01 | 0.299 |
| R-HSA-8963743 | Digestion and absorption | 5.068877e-01 | 0.295 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.068877e-01 | 0.295 |
| R-HSA-8848021 | Signaling by PTK6 | 5.068877e-01 | 0.295 |
| R-HSA-69306 | DNA Replication | 5.076226e-01 | 0.294 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.076226e-01 | 0.294 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 5.117847e-01 | 0.291 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.117847e-01 | 0.291 |
| R-HSA-5688426 | Deubiquitination | 5.158136e-01 | 0.288 |
| R-HSA-6798695 | Neutrophil degranulation | 5.165706e-01 | 0.287 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.166333e-01 | 0.287 |
| R-HSA-9612973 | Autophagy | 5.168820e-01 | 0.287 |
| R-HSA-162587 | HIV Life Cycle | 5.199430e-01 | 0.284 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.261875e-01 | 0.279 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.261875e-01 | 0.279 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.290486e-01 | 0.277 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.296226e-01 | 0.276 |
| R-HSA-167172 | Transcription of the HIV genome | 5.308939e-01 | 0.275 |
| R-HSA-5218859 | Regulated Necrosis | 5.308939e-01 | 0.275 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.401679e-01 | 0.267 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.401679e-01 | 0.267 |
| R-HSA-8978934 | Metabolism of cofactors | 5.447364e-01 | 0.264 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.492597e-01 | 0.260 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.537384e-01 | 0.257 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.581729e-01 | 0.253 |
| R-HSA-8852135 | Protein ubiquitination | 5.625635e-01 | 0.250 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.625635e-01 | 0.250 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.754770e-01 | 0.240 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.754770e-01 | 0.240 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.754770e-01 | 0.240 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.756173e-01 | 0.240 |
| R-HSA-9833482 | PKR-mediated signaling | 5.838748e-01 | 0.234 |
| R-HSA-6806834 | Signaling by MET | 5.838748e-01 | 0.234 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.041540e-01 | 0.219 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.041540e-01 | 0.219 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.127673e-01 | 0.213 |
| R-HSA-9663891 | Selective autophagy | 6.196678e-01 | 0.208 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.213479e-01 | 0.207 |
| R-HSA-202424 | Downstream TCR signaling | 6.271965e-01 | 0.203 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.382128e-01 | 0.195 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.418126e-01 | 0.193 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.418126e-01 | 0.193 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.558590e-01 | 0.183 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.589087e-01 | 0.181 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.660334e-01 | 0.177 |
| R-HSA-8957322 | Metabolism of steroids | 6.666501e-01 | 0.176 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.693579e-01 | 0.174 |
| R-HSA-397014 | Muscle contraction | 6.725103e-01 | 0.172 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.726496e-01 | 0.172 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.748021e-01 | 0.171 |
| R-HSA-1483255 | PI Metabolism | 6.759087e-01 | 0.170 |
| R-HSA-9833110 | RSV-host interactions | 6.854939e-01 | 0.164 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.854939e-01 | 0.164 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.854939e-01 | 0.164 |
| R-HSA-109582 | Hemostasis | 6.927181e-01 | 0.159 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.947972e-01 | 0.158 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.947972e-01 | 0.158 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.008470e-01 | 0.154 |
| R-HSA-202403 | TCR signaling | 7.038271e-01 | 0.153 |
| R-HSA-162906 | HIV Infection | 7.055422e-01 | 0.151 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.076433e-01 | 0.150 |
| R-HSA-162582 | Signal Transduction | 7.086270e-01 | 0.150 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.086948e-01 | 0.150 |
| R-HSA-9824446 | Viral Infection Pathways | 7.108862e-01 | 0.148 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.118081e-01 | 0.148 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.154551e-01 | 0.145 |
| R-HSA-8939211 | ESR-mediated signaling | 7.259982e-01 | 0.139 |
| R-HSA-373760 | L1CAM interactions | 7.266294e-01 | 0.139 |
| R-HSA-157118 | Signaling by NOTCH | 7.318978e-01 | 0.136 |
| R-HSA-5693538 | Homology Directed Repair | 7.320519e-01 | 0.135 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.347229e-01 | 0.134 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 7.370958e-01 | 0.132 |
| R-HSA-68875 | Mitotic Prophase | 7.373675e-01 | 0.132 |
| R-HSA-1280218 | Adaptive Immune System | 7.395213e-01 | 0.131 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.451450e-01 | 0.128 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.526936e-01 | 0.123 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.526936e-01 | 0.123 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.526936e-01 | 0.123 |
| R-HSA-69481 | G2/M Checkpoints | 7.576022e-01 | 0.121 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.647840e-01 | 0.116 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.776814e-01 | 0.109 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.819426e-01 | 0.107 |
| R-HSA-6807070 | PTEN Regulation | 7.893545e-01 | 0.103 |
| R-HSA-9664407 | Parasite infection | 7.914574e-01 | 0.102 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.914574e-01 | 0.102 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.914574e-01 | 0.102 |
| R-HSA-1632852 | Macroautophagy | 7.935395e-01 | 0.100 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.016633e-01 | 0.096 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.022792e-01 | 0.096 |
| R-HSA-9658195 | Leishmania infection | 8.022792e-01 | 0.096 |
| R-HSA-2187338 | Visual phototransduction | 8.075470e-01 | 0.093 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.132572e-01 | 0.090 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.139471e-01 | 0.089 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.206096e-01 | 0.086 |
| R-HSA-73887 | Death Receptor Signaling | 8.206096e-01 | 0.086 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.206096e-01 | 0.086 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.222932e-01 | 0.085 |
| R-HSA-1989781 | PPARA activates gene expression | 8.224023e-01 | 0.085 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.236513e-01 | 0.084 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.259345e-01 | 0.083 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.276743e-01 | 0.082 |
| R-HSA-5619102 | SLC transporter disorders | 8.425752e-01 | 0.074 |
| R-HSA-72306 | tRNA processing | 8.487798e-01 | 0.071 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.546611e-01 | 0.068 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.641901e-01 | 0.063 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.759097e-01 | 0.058 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.768911e-01 | 0.057 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.835638e-01 | 0.054 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.915153e-01 | 0.050 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.040733e-01 | 0.044 |
| R-HSA-9748784 | Drug ADME | 9.076737e-01 | 0.042 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.173715e-01 | 0.037 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.237820e-01 | 0.034 |
| R-HSA-5663205 | Infectious disease | 9.272153e-01 | 0.033 |
| R-HSA-9679506 | SARS-CoV Infections | 9.280506e-01 | 0.032 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.311043e-01 | 0.031 |
| R-HSA-416476 | G alpha (q) signalling events | 9.419827e-01 | 0.026 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.496461e-01 | 0.022 |
| R-HSA-1483257 | Phospholipid metabolism | 9.576111e-01 | 0.019 |
| R-HSA-1474244 | Extracellular matrix organization | 9.705812e-01 | 0.013 |
| R-HSA-382551 | Transport of small molecules | 9.734528e-01 | 0.012 |
| R-HSA-913531 | Interferon Signaling | 9.828434e-01 | 0.008 |
| R-HSA-168249 | Innate Immune System | 9.833732e-01 | 0.007 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.851257e-01 | 0.007 |
| R-HSA-8978868 | Fatty acid metabolism | 9.865686e-01 | 0.006 |
| R-HSA-597592 | Post-translational protein modification | 9.886464e-01 | 0.005 |
| R-HSA-449147 | Signaling by Interleukins | 9.890175e-01 | 0.005 |
| R-HSA-168256 | Immune System | 9.934194e-01 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 9.938149e-01 | 0.003 |
| R-HSA-211859 | Biological oxidations | 9.959076e-01 | 0.002 |
| R-HSA-1643685 | Disease | 9.977355e-01 | 0.001 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.989726e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.994327e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.996967e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998729e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999889e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999978e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK3 |
0.814 | 0.389 | 1 | 0.677 |
CLK3 |
0.813 | 0.269 | 1 | 0.890 |
NLK |
0.812 | 0.287 | 1 | 0.851 |
CDK2 |
0.811 | 0.401 | 1 | 0.773 |
CDK5 |
0.811 | 0.303 | 1 | 0.780 |
COT |
0.810 | 0.152 | 2 | 0.810 |
MLK3 |
0.806 | 0.391 | 2 | 0.823 |
CDK1 |
0.805 | 0.290 | 1 | 0.726 |
MST4 |
0.802 | 0.277 | 2 | 0.870 |
PKCD |
0.799 | 0.256 | 2 | 0.852 |
ERK5 |
0.798 | 0.140 | 1 | 0.820 |
MLK1 |
0.798 | 0.244 | 2 | 0.839 |
NEK6 |
0.796 | 0.144 | -2 | 0.733 |
CDKL5 |
0.796 | 0.111 | -3 | 0.766 |
CDKL1 |
0.796 | 0.108 | -3 | 0.772 |
PKCB |
0.796 | 0.279 | 2 | 0.833 |
IRE2 |
0.796 | 0.202 | 2 | 0.816 |
MTOR |
0.795 | 0.063 | 1 | 0.757 |
ULK2 |
0.795 | 0.077 | 2 | 0.765 |
PKN2 |
0.793 | 0.178 | -3 | 0.813 |
IRE1 |
0.793 | 0.180 | 1 | 0.764 |
PKCA |
0.793 | 0.251 | 2 | 0.829 |
PKCG |
0.792 | 0.263 | 2 | 0.825 |
PIM3 |
0.792 | 0.033 | -3 | 0.791 |
MOS |
0.791 | 0.010 | 1 | 0.831 |
DSTYK |
0.791 | 0.076 | 2 | 0.814 |
NUAK2 |
0.791 | 0.080 | -3 | 0.818 |
PRPK |
0.791 | -0.046 | -1 | 0.868 |
SRPK1 |
0.790 | 0.098 | -3 | 0.711 |
KIS |
0.789 | 0.069 | 1 | 0.776 |
NEK7 |
0.789 | 0.056 | -3 | 0.854 |
CDC7 |
0.789 | -0.067 | 1 | 0.798 |
GCN2 |
0.788 | -0.085 | 2 | 0.730 |
CHAK2 |
0.788 | 0.087 | -1 | 0.807 |
SRPK2 |
0.787 | 0.096 | -3 | 0.640 |
PKN3 |
0.786 | 0.064 | -3 | 0.802 |
PKCH |
0.786 | 0.228 | 2 | 0.809 |
CDK6 |
0.786 | 0.252 | 1 | 0.723 |
TGFBR2 |
0.786 | 0.011 | -2 | 0.633 |
RAF1 |
0.785 | -0.076 | 1 | 0.773 |
WNK1 |
0.785 | 0.067 | -2 | 0.724 |
NIK |
0.785 | 0.118 | -3 | 0.854 |
CDK10 |
0.784 | 0.223 | 1 | 0.730 |
BMPR2 |
0.784 | -0.059 | -2 | 0.739 |
NEK9 |
0.784 | 0.091 | 2 | 0.819 |
MLK4 |
0.783 | 0.186 | 2 | 0.761 |
ATR |
0.783 | -0.024 | 1 | 0.796 |
IKKB |
0.783 | -0.103 | -2 | 0.663 |
CDK16 |
0.783 | 0.225 | 1 | 0.673 |
CDK8 |
0.783 | 0.081 | 1 | 0.760 |
PKCZ |
0.783 | 0.171 | 2 | 0.807 |
CHAK1 |
0.782 | 0.204 | 2 | 0.759 |
MLK2 |
0.782 | 0.089 | 2 | 0.810 |
ICK |
0.781 | 0.064 | -3 | 0.810 |
HIPK4 |
0.781 | 0.017 | 1 | 0.825 |
CDK19 |
0.780 | 0.091 | 1 | 0.731 |
ULK1 |
0.780 | -0.012 | -3 | 0.830 |
CLK1 |
0.780 | 0.142 | -3 | 0.727 |
PIM1 |
0.780 | 0.054 | -3 | 0.746 |
CDK18 |
0.780 | 0.145 | 1 | 0.708 |
PKCE |
0.780 | 0.284 | 2 | 0.826 |
ERK2 |
0.779 | 0.163 | 1 | 0.747 |
RIPK3 |
0.779 | -0.036 | 3 | 0.522 |
CDK14 |
0.779 | 0.181 | 1 | 0.739 |
CAMK1B |
0.779 | -0.061 | -3 | 0.840 |
WNK3 |
0.779 | -0.075 | 1 | 0.756 |
CDK7 |
0.778 | 0.092 | 1 | 0.765 |
ERK1 |
0.778 | 0.142 | 1 | 0.712 |
CDK13 |
0.778 | 0.106 | 1 | 0.739 |
TBK1 |
0.778 | -0.141 | 1 | 0.669 |
P38A |
0.778 | 0.135 | 1 | 0.777 |
RSK2 |
0.778 | 0.009 | -3 | 0.744 |
PHKG1 |
0.777 | 0.098 | -3 | 0.796 |
IKKE |
0.777 | -0.132 | 1 | 0.669 |
SRPK3 |
0.777 | 0.063 | -3 | 0.684 |
PRKD2 |
0.777 | 0.021 | -3 | 0.752 |
PDHK1 |
0.777 | -0.180 | 1 | 0.784 |
PDHK4 |
0.777 | -0.269 | 1 | 0.799 |
PKR |
0.777 | 0.185 | 1 | 0.807 |
AMPKA1 |
0.776 | -0.031 | -3 | 0.828 |
CDK17 |
0.775 | 0.137 | 1 | 0.659 |
ANKRD3 |
0.775 | 0.003 | 1 | 0.791 |
NUAK1 |
0.775 | 0.021 | -3 | 0.775 |
MARK4 |
0.775 | -0.095 | 4 | 0.555 |
PKCT |
0.775 | 0.195 | 2 | 0.816 |
MST3 |
0.775 | 0.305 | 2 | 0.859 |
IRAK4 |
0.775 | 0.183 | 1 | 0.760 |
CAMK2G |
0.774 | -0.142 | 2 | 0.680 |
NDR1 |
0.774 | -0.042 | -3 | 0.801 |
JNK3 |
0.774 | 0.114 | 1 | 0.739 |
GRK5 |
0.774 | -0.123 | -3 | 0.815 |
CAMLCK |
0.774 | -0.058 | -2 | 0.687 |
NDR2 |
0.773 | -0.090 | -3 | 0.800 |
P38B |
0.773 | 0.121 | 1 | 0.721 |
PKCI |
0.773 | 0.183 | 2 | 0.804 |
DAPK2 |
0.773 | -0.070 | -3 | 0.845 |
JNK2 |
0.773 | 0.123 | 1 | 0.707 |
NEK2 |
0.773 | 0.074 | 2 | 0.807 |
P90RSK |
0.773 | -0.013 | -3 | 0.742 |
CLK4 |
0.772 | 0.081 | -3 | 0.737 |
RSK3 |
0.772 | 0.001 | -3 | 0.738 |
NIM1 |
0.772 | -0.049 | 3 | 0.573 |
YSK4 |
0.772 | 0.071 | 1 | 0.707 |
MAPKAPK3 |
0.772 | -0.017 | -3 | 0.760 |
QIK |
0.772 | -0.029 | -3 | 0.824 |
P38G |
0.771 | 0.122 | 1 | 0.651 |
TSSK2 |
0.771 | -0.043 | -5 | 0.826 |
CDK4 |
0.771 | 0.179 | 1 | 0.706 |
PHKG2 |
0.771 | 0.133 | -3 | 0.782 |
AMPKA2 |
0.771 | -0.031 | -3 | 0.796 |
GRK6 |
0.770 | -0.063 | 1 | 0.766 |
DLK |
0.770 | -0.032 | 1 | 0.763 |
P70S6KB |
0.770 | -0.009 | -3 | 0.772 |
CDK12 |
0.770 | 0.095 | 1 | 0.715 |
GRK1 |
0.769 | -0.068 | -2 | 0.661 |
MNK1 |
0.769 | 0.067 | -2 | 0.661 |
CDK9 |
0.768 | 0.078 | 1 | 0.742 |
TSSK1 |
0.768 | -0.056 | -3 | 0.844 |
PRKD1 |
0.768 | -0.079 | -3 | 0.803 |
HRI |
0.768 | 0.085 | -2 | 0.696 |
DYRK2 |
0.768 | 0.051 | 1 | 0.765 |
P38D |
0.768 | 0.130 | 1 | 0.684 |
SKMLCK |
0.768 | -0.105 | -2 | 0.685 |
PINK1 |
0.767 | 0.070 | 1 | 0.850 |
BCKDK |
0.767 | -0.166 | -1 | 0.814 |
EEF2K |
0.767 | 0.319 | 3 | 0.793 |
PIM2 |
0.767 | 0.055 | -3 | 0.725 |
ERK7 |
0.767 | 0.103 | 2 | 0.561 |
PRKD3 |
0.767 | 0.019 | -3 | 0.732 |
HUNK |
0.767 | -0.178 | 2 | 0.723 |
IKKA |
0.767 | -0.113 | -2 | 0.670 |
MELK |
0.767 | -0.025 | -3 | 0.787 |
HIPK1 |
0.767 | 0.098 | 1 | 0.782 |
MNK2 |
0.766 | 0.028 | -2 | 0.643 |
MASTL |
0.766 | -0.233 | -2 | 0.708 |
AKT2 |
0.766 | 0.068 | -3 | 0.666 |
ZAK |
0.766 | 0.139 | 1 | 0.715 |
QSK |
0.765 | -0.068 | 4 | 0.557 |
VRK2 |
0.765 | -0.062 | 1 | 0.831 |
TAO2 |
0.765 | 0.245 | 2 | 0.861 |
TNIK |
0.765 | 0.355 | 3 | 0.787 |
PKACG |
0.764 | -0.057 | -2 | 0.607 |
TAO3 |
0.764 | 0.189 | 1 | 0.739 |
HIPK2 |
0.764 | 0.089 | 1 | 0.700 |
PKG2 |
0.763 | -0.002 | -2 | 0.542 |
PLK1 |
0.763 | -0.092 | -2 | 0.712 |
AURC |
0.763 | -0.028 | -2 | 0.502 |
SMG1 |
0.763 | -0.024 | 1 | 0.753 |
HGK |
0.763 | 0.286 | 3 | 0.758 |
CAMK4 |
0.762 | -0.090 | -3 | 0.802 |
BMPR1B |
0.762 | -0.014 | 1 | 0.742 |
MAPKAPK2 |
0.762 | -0.035 | -3 | 0.704 |
MPSK1 |
0.762 | 0.093 | 1 | 0.780 |
MEK1 |
0.761 | -0.113 | 2 | 0.759 |
NEK8 |
0.761 | 0.173 | 2 | 0.831 |
GRK7 |
0.761 | -0.006 | 1 | 0.700 |
NEK5 |
0.761 | 0.088 | 1 | 0.778 |
CLK2 |
0.761 | 0.067 | -3 | 0.710 |
DYRK1A |
0.761 | 0.049 | 1 | 0.799 |
MARK3 |
0.761 | -0.070 | 4 | 0.540 |
AKT1 |
0.760 | 0.071 | -3 | 0.684 |
RIPK1 |
0.760 | -0.181 | 1 | 0.749 |
MEKK2 |
0.760 | 0.103 | 2 | 0.789 |
SIK |
0.760 | -0.060 | -3 | 0.742 |
PERK |
0.759 | -0.019 | -2 | 0.694 |
MEKK1 |
0.759 | 0.002 | 1 | 0.754 |
SNRK |
0.759 | -0.109 | 2 | 0.661 |
MEK5 |
0.759 | 0.026 | 2 | 0.789 |
TTBK2 |
0.759 | -0.141 | 2 | 0.653 |
LATS1 |
0.759 | -0.044 | -3 | 0.813 |
HIPK3 |
0.759 | 0.067 | 1 | 0.761 |
PRP4 |
0.759 | 0.029 | -3 | 0.670 |
ATM |
0.758 | -0.088 | 1 | 0.731 |
LATS2 |
0.758 | -0.101 | -5 | 0.743 |
MINK |
0.758 | 0.262 | 1 | 0.735 |
CAMKK1 |
0.758 | 0.127 | -2 | 0.752 |
MARK2 |
0.757 | -0.107 | 4 | 0.496 |
RSK4 |
0.757 | -0.010 | -3 | 0.706 |
ALK4 |
0.757 | -0.111 | -2 | 0.657 |
AURB |
0.757 | -0.044 | -2 | 0.502 |
CAMK2D |
0.757 | -0.155 | -3 | 0.827 |
PAK3 |
0.757 | -0.098 | -2 | 0.622 |
DRAK1 |
0.757 | -0.020 | 1 | 0.686 |
MEKK3 |
0.756 | 0.011 | 1 | 0.733 |
NEK4 |
0.756 | 0.163 | 1 | 0.737 |
SSTK |
0.756 | -0.040 | 4 | 0.556 |
BRSK2 |
0.755 | -0.101 | -3 | 0.801 |
WNK4 |
0.755 | -0.029 | -2 | 0.731 |
NEK11 |
0.755 | 0.120 | 1 | 0.730 |
FAM20C |
0.755 | -0.078 | 2 | 0.431 |
SGK3 |
0.755 | -0.019 | -3 | 0.737 |
PKN1 |
0.755 | 0.081 | -3 | 0.715 |
PAK1 |
0.754 | -0.092 | -2 | 0.617 |
GSK3A |
0.754 | -0.027 | 4 | 0.243 |
GRK4 |
0.754 | -0.217 | -2 | 0.669 |
CAMK1G |
0.754 | -0.030 | -3 | 0.746 |
ACVR2A |
0.753 | -0.077 | -2 | 0.624 |
PAK6 |
0.753 | -0.040 | -2 | 0.562 |
GCK |
0.753 | 0.183 | 1 | 0.743 |
KHS2 |
0.753 | 0.235 | 1 | 0.738 |
MYLK4 |
0.753 | -0.066 | -2 | 0.597 |
LOK |
0.753 | 0.155 | -2 | 0.679 |
GSK3B |
0.752 | -0.059 | 4 | 0.235 |
TGFBR1 |
0.752 | -0.120 | -2 | 0.628 |
MARK1 |
0.752 | -0.105 | 4 | 0.546 |
ACVR2B |
0.752 | -0.091 | -2 | 0.646 |
BRAF |
0.751 | -0.062 | -4 | 0.845 |
DYRK1B |
0.751 | 0.051 | 1 | 0.744 |
BRSK1 |
0.751 | -0.108 | -3 | 0.769 |
MEKK6 |
0.751 | 0.129 | 1 | 0.741 |
MSK2 |
0.750 | -0.093 | -3 | 0.711 |
KHS1 |
0.750 | 0.200 | 1 | 0.724 |
GAK |
0.750 | 0.064 | 1 | 0.819 |
MAK |
0.750 | 0.111 | -2 | 0.640 |
MOK |
0.750 | 0.116 | 1 | 0.779 |
IRAK1 |
0.750 | -0.048 | -1 | 0.761 |
MYO3A |
0.750 | 0.353 | 1 | 0.741 |
JNK1 |
0.750 | 0.081 | 1 | 0.698 |
PKACB |
0.750 | -0.046 | -2 | 0.530 |
MST2 |
0.750 | 0.100 | 1 | 0.744 |
CAMKK2 |
0.750 | 0.072 | -2 | 0.737 |
HPK1 |
0.749 | 0.156 | 1 | 0.725 |
BUB1 |
0.749 | 0.134 | -5 | 0.757 |
CAMK2A |
0.749 | -0.105 | 2 | 0.644 |
LRRK2 |
0.749 | 0.131 | 2 | 0.810 |
PAK2 |
0.749 | -0.122 | -2 | 0.610 |
DNAPK |
0.749 | -0.070 | 1 | 0.670 |
MST1 |
0.749 | 0.186 | 1 | 0.730 |
SMMLCK |
0.748 | -0.030 | -3 | 0.798 |
DYRK3 |
0.748 | 0.028 | 1 | 0.776 |
PLK3 |
0.748 | -0.137 | 2 | 0.641 |
DCAMKL1 |
0.748 | -0.034 | -3 | 0.759 |
YSK1 |
0.748 | 0.193 | 2 | 0.831 |
CK1E |
0.748 | -0.030 | -3 | 0.504 |
PLK4 |
0.748 | -0.117 | 2 | 0.583 |
NEK1 |
0.748 | 0.167 | 1 | 0.742 |
MYO3B |
0.748 | 0.289 | 2 | 0.848 |
TAK1 |
0.748 | 0.137 | 1 | 0.761 |
CHK1 |
0.747 | -0.111 | -3 | 0.810 |
DYRK4 |
0.747 | 0.038 | 1 | 0.715 |
PRKX |
0.746 | -0.019 | -3 | 0.644 |
MAP3K15 |
0.746 | 0.102 | 1 | 0.699 |
P70S6K |
0.746 | -0.023 | -3 | 0.693 |
AKT3 |
0.746 | 0.052 | -3 | 0.599 |
ALK2 |
0.746 | -0.119 | -2 | 0.645 |
CAMK2B |
0.745 | -0.154 | 2 | 0.605 |
SLK |
0.745 | 0.083 | -2 | 0.637 |
TLK2 |
0.745 | -0.194 | 1 | 0.751 |
DCAMKL2 |
0.745 | -0.031 | -3 | 0.792 |
GRK2 |
0.745 | -0.099 | -2 | 0.565 |
LKB1 |
0.744 | 0.024 | -3 | 0.825 |
TLK1 |
0.743 | -0.142 | -2 | 0.658 |
BMPR1A |
0.742 | -0.065 | 1 | 0.724 |
AURA |
0.742 | -0.077 | -2 | 0.458 |
HASPIN |
0.741 | 0.119 | -1 | 0.636 |
MSK1 |
0.741 | -0.099 | -3 | 0.718 |
TTBK1 |
0.741 | -0.091 | 2 | 0.586 |
MAPKAPK5 |
0.741 | -0.112 | -3 | 0.708 |
VRK1 |
0.740 | -0.027 | 2 | 0.822 |
PDK1 |
0.739 | -0.055 | 1 | 0.735 |
RIPK2 |
0.739 | -0.070 | 1 | 0.667 |
CK1D |
0.738 | -0.030 | -3 | 0.456 |
TAO1 |
0.738 | 0.185 | 1 | 0.666 |
STK33 |
0.738 | -0.024 | 2 | 0.572 |
PBK |
0.737 | 0.049 | 1 | 0.758 |
OSR1 |
0.737 | 0.144 | 2 | 0.771 |
CK2A2 |
0.737 | -0.031 | 1 | 0.679 |
CHK2 |
0.737 | 0.006 | -3 | 0.619 |
MRCKB |
0.736 | 0.008 | -3 | 0.715 |
PASK |
0.736 | -0.099 | -3 | 0.812 |
TTK |
0.735 | 0.088 | -2 | 0.680 |
PKACA |
0.735 | -0.056 | -2 | 0.479 |
MRCKA |
0.734 | -0.002 | -3 | 0.732 |
NEK3 |
0.734 | 0.024 | 1 | 0.705 |
ROCK2 |
0.734 | 0.007 | -3 | 0.756 |
CK1A2 |
0.732 | -0.043 | -3 | 0.456 |
CK1G1 |
0.732 | -0.078 | -3 | 0.485 |
CAMK1D |
0.731 | -0.077 | -3 | 0.674 |
DAPK3 |
0.731 | -0.079 | -3 | 0.768 |
MEK2 |
0.730 | -0.120 | 2 | 0.752 |
SGK1 |
0.729 | -0.014 | -3 | 0.582 |
CK2A1 |
0.728 | -0.041 | 1 | 0.656 |
PAK5 |
0.728 | -0.104 | -2 | 0.509 |
BIKE |
0.727 | 0.074 | 1 | 0.718 |
CAMK1A |
0.727 | -0.039 | -3 | 0.635 |
GRK3 |
0.726 | -0.118 | -2 | 0.517 |
DMPK1 |
0.725 | 0.017 | -3 | 0.735 |
ROCK1 |
0.724 | 0.011 | -3 | 0.726 |
PDHK3_TYR |
0.722 | 0.018 | 4 | 0.553 |
DAPK1 |
0.722 | -0.093 | -3 | 0.748 |
ASK1 |
0.722 | 0.059 | 1 | 0.686 |
TESK1_TYR |
0.722 | 0.136 | 3 | 0.689 |
LIMK2_TYR |
0.721 | 0.163 | -3 | 0.871 |
PLK2 |
0.721 | -0.102 | -3 | 0.761 |
PAK4 |
0.720 | -0.116 | -2 | 0.497 |
SBK |
0.718 | -0.031 | -3 | 0.557 |
PKG1 |
0.717 | -0.074 | -2 | 0.459 |
PINK1_TYR |
0.716 | 0.100 | 1 | 0.783 |
LIMK1_TYR |
0.716 | 0.117 | 2 | 0.816 |
PKMYT1_TYR |
0.715 | -0.008 | 3 | 0.633 |
PDHK4_TYR |
0.714 | -0.042 | 2 | 0.783 |
AAK1 |
0.713 | 0.089 | 1 | 0.635 |
TNNI3K_TYR |
0.713 | 0.145 | 1 | 0.772 |
MAP2K4_TYR |
0.712 | -0.116 | -1 | 0.892 |
ROS1 |
0.712 | 0.045 | 3 | 0.584 |
MAP2K6_TYR |
0.712 | -0.092 | -1 | 0.894 |
MAP2K7_TYR |
0.711 | -0.134 | 2 | 0.784 |
BMPR2_TYR |
0.710 | -0.029 | -1 | 0.885 |
ALPHAK3 |
0.710 | -0.044 | -1 | 0.781 |
TYRO3 |
0.709 | 0.014 | 3 | 0.612 |
TYK2 |
0.708 | 0.009 | 1 | 0.734 |
WEE1_TYR |
0.708 | 0.157 | -1 | 0.762 |
CRIK |
0.708 | -0.030 | -3 | 0.684 |
EPHA6 |
0.707 | 0.001 | -1 | 0.882 |
PDHK1_TYR |
0.707 | -0.119 | -1 | 0.907 |
LCK |
0.707 | 0.075 | -1 | 0.874 |
STLK3 |
0.704 | -0.095 | 1 | 0.679 |
YANK3 |
0.704 | -0.078 | 2 | 0.343 |
JAK2 |
0.703 | -0.060 | 1 | 0.732 |
HCK |
0.702 | 0.004 | -1 | 0.875 |
JAK1 |
0.701 | 0.047 | 1 | 0.671 |
RET |
0.701 | -0.112 | 1 | 0.736 |
FGR |
0.701 | -0.046 | 1 | 0.785 |
CSF1R |
0.701 | -0.076 | 3 | 0.567 |
MST1R |
0.700 | -0.115 | 3 | 0.577 |
YES1 |
0.700 | -0.056 | -1 | 0.878 |
EPHB4 |
0.699 | -0.094 | -1 | 0.876 |
ITK |
0.699 | -0.008 | -1 | 0.845 |
BLK |
0.698 | 0.015 | -1 | 0.874 |
JAK3 |
0.698 | -0.050 | 1 | 0.714 |
TXK |
0.698 | -0.025 | 1 | 0.767 |
NEK10_TYR |
0.697 | -0.007 | 1 | 0.623 |
TNK1 |
0.697 | -0.024 | 3 | 0.576 |
ABL2 |
0.697 | -0.056 | -1 | 0.837 |
BTK |
0.696 | -0.006 | -1 | 0.814 |
DDR1 |
0.696 | -0.166 | 4 | 0.520 |
CK1A |
0.696 | -0.077 | -3 | 0.362 |
FLT3 |
0.695 | -0.050 | 3 | 0.599 |
PDGFRB |
0.695 | -0.070 | 3 | 0.588 |
KDR |
0.694 | -0.037 | 3 | 0.516 |
ABL1 |
0.693 | -0.062 | -1 | 0.830 |
TEC |
0.693 | -0.017 | -1 | 0.783 |
PDGFRA |
0.692 | -0.066 | 3 | 0.603 |
TEK |
0.691 | -0.102 | 3 | 0.533 |
FER |
0.691 | -0.156 | 1 | 0.797 |
INSRR |
0.691 | -0.143 | 3 | 0.527 |
TNK2 |
0.688 | -0.137 | 3 | 0.505 |
ALK |
0.688 | -0.104 | 3 | 0.499 |
KIT |
0.687 | -0.130 | 3 | 0.560 |
EPHB1 |
0.686 | -0.153 | 1 | 0.764 |
PTK6 |
0.685 | -0.119 | -1 | 0.769 |
LYN |
0.685 | -0.053 | 3 | 0.504 |
BMX |
0.685 | -0.072 | -1 | 0.764 |
EPHA4 |
0.684 | -0.132 | 2 | 0.642 |
EPHB3 |
0.684 | -0.154 | -1 | 0.866 |
EPHB2 |
0.683 | -0.150 | -1 | 0.862 |
FRK |
0.683 | -0.071 | -1 | 0.882 |
FYN |
0.682 | -0.057 | -1 | 0.854 |
SRMS |
0.681 | -0.187 | 1 | 0.769 |
FGFR1 |
0.681 | -0.187 | 3 | 0.516 |
FGFR2 |
0.681 | -0.212 | 3 | 0.532 |
LTK |
0.680 | -0.120 | 3 | 0.499 |
MERTK |
0.680 | -0.153 | 3 | 0.513 |
AXL |
0.680 | -0.171 | 3 | 0.518 |
FLT1 |
0.680 | -0.081 | -1 | 0.865 |
MET |
0.679 | -0.155 | 3 | 0.535 |
NTRK2 |
0.678 | -0.152 | 3 | 0.513 |
MUSK |
0.678 | -0.010 | 1 | 0.583 |
YANK2 |
0.678 | -0.071 | 2 | 0.356 |
INSR |
0.678 | -0.139 | 3 | 0.517 |
DDR2 |
0.676 | -0.133 | 3 | 0.496 |
EPHA1 |
0.676 | -0.140 | 3 | 0.508 |
FLT4 |
0.676 | -0.141 | 3 | 0.507 |
CK1G3 |
0.676 | -0.070 | -3 | 0.312 |
ERBB2 |
0.675 | -0.153 | 1 | 0.685 |
EPHA7 |
0.675 | -0.135 | 2 | 0.661 |
EPHA3 |
0.673 | -0.161 | 2 | 0.633 |
SRC |
0.673 | -0.100 | -1 | 0.847 |
MATK |
0.672 | -0.086 | -1 | 0.745 |
NTRK1 |
0.671 | -0.239 | -1 | 0.852 |
FGFR3 |
0.671 | -0.191 | 3 | 0.507 |
PTK2B |
0.670 | -0.128 | -1 | 0.810 |
NTRK3 |
0.664 | -0.198 | -1 | 0.807 |
PTK2 |
0.664 | -0.071 | -1 | 0.819 |
EPHA8 |
0.663 | -0.158 | -1 | 0.844 |
EPHA5 |
0.662 | -0.182 | 2 | 0.626 |
EGFR |
0.658 | -0.142 | 1 | 0.589 |
IGF1R |
0.658 | -0.174 | 3 | 0.458 |
SYK |
0.658 | -0.096 | -1 | 0.815 |
CK1G2 |
0.656 | -0.095 | -3 | 0.405 |
CSK |
0.656 | -0.196 | 2 | 0.671 |
EPHA2 |
0.652 | -0.172 | -1 | 0.818 |
FGFR4 |
0.650 | -0.197 | -1 | 0.801 |
ERBB4 |
0.646 | -0.145 | 1 | 0.616 |
FES |
0.645 | -0.163 | -1 | 0.737 |
ZAP70 |
0.635 | -0.101 | -1 | 0.720 |