Motif 76 (n=119)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E7EW31 | PROB1 | S865 | ochoa | Proline-rich basic protein 1 | None |
| H0YIS7 | RNASEK-C17orf49 | S77 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| H3BU86 | STX16-NPEPL1 | S35 | ochoa | Syntaxin-16 | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037772}. |
| O00192 | ARVCF | S864 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00764 | PDXK | S285 | ochoa | Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) | Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503, PubMed:9099727). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions. {ECO:0000269|PubMed:10987144, ECO:0000269|PubMed:17766369, ECO:0000269|PubMed:19351586, ECO:0000269|PubMed:31187503, ECO:0000269|PubMed:9099727, ECO:0000305}. |
| O14662 | STX16 | S35 | ochoa | Syntaxin-16 (Syn16) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O15061 | SYNM | S1107 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43379 | WDR62 | S1249 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43602 | DCX | S297 | psp | Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}. |
| O60711 | LPXN | S208 | ochoa | Leupaxin | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}. |
| O75369 | FLNB | S886 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S224 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75420 | GIGYF1 | S406 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O75962 | TRIO | S2417 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O95071 | UBR5 | S2424 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95235 | KIF20A | S21 | ochoa|psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| P04920 | SLC4A2 | S173 | ochoa | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
| P10746 | UROS | S245 | ochoa | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}. |
| P11137 | MAP2 | S1324 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P17029 | ZKSCAN1 | S208 | ochoa | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P19484 | TFEB | S122 | ochoa|psp | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P21817 | RYR1 | S2000 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P26232 | CTNNA2 | S262 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P29966 | MARCKS | S27 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P31939 | ATIC | S112 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P42566 | EPS15 | S108 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42704 | LRPPRC | S54 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P43268 | ETV4 | S140 | ochoa | ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) | Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}. |
| P46013 | MKI67 | S827 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1376 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49023 | PXN | S303 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49916 | LIG3 | S242 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| Q02086 | SP2 | S386 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q02410 | APBA1 | S313 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q12888 | TP53BP1 | S1114 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13342 | SP140 | S185 | ochoa | Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}. |
| Q13555 | CAMK2G | S423 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q14160 | SCRIB | S1486 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14526 | HIC1 | S237 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q15027 | ACAP1 | S371 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}. |
| Q2M3G4 | SHROOM1 | S49 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q2M3G4 | SHROOM1 | S364 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q2TAZ0 | ATG2A | S1630 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q4KMP7 | TBC1D10B | S111 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q4KMQ1 | TPRN | S418 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q5T0W9 | FAM83B | S869 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T0Z8 | C6orf132 | S1011 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5TCX8 | MAP3K21 | S115 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5VWQ0 | RSBN1 | S547 | ochoa | Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) | Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}. |
| Q68CZ2 | TNS3 | S1293 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68DK7 | MSL1 | S450 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6BDS2 | BLTP3A | S988 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6P4R8 | NFRKB | S896 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PCB5 | RSBN1L | S536 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6UB99 | ANKRD11 | S2021 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6ZS17 | RIPOR1 | S171 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZUT6 | CCDC9B | S55 | ochoa | Coiled-coil domain-containing protein 9B | None |
| Q6ZW76 | ANKS3 | S416 | ochoa | Ankyrin repeat and SAM domain-containing protein 3 | May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}. |
| Q6ZWB6 | KCTD8 | S78 | ochoa | BTB/POZ domain-containing protein KCTD8 | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q7Z6J0 | SH3RF1 | S532 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q8IWD4 | CCDC117 | S53 | ochoa | Coiled-coil domain-containing protein 117 | Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B. {ECO:0000269|PubMed:30742009}. |
| Q8IWX8 | CHERP | S186 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IXF0 | NPAS3 | S748 | ochoa | Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) | May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}. |
| Q8IXM2 | BACC1 | S36 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IZ21 | PHACTR4 | S118 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N1G1 | REXO1 | S914 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8TE67 | EPS8L3 | S231 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
| Q8WU79 | SMAP2 | S177 | ochoa | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}. |
| Q92817 | EVPL | S1813 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
| Q92871 | PMM1 | S242 | ochoa | Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22) | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}. |
| Q96F45 | ZNF503 | S228 | ochoa | Zinc finger protein 503 | May function as a transcriptional repressor. {ECO:0000250}. |
| Q96H79 | ZC3HAV1L | S257 | ochoa | Zinc finger CCCH-type antiviral protein 1-like | None |
| Q96IF1 | AJUBA | Y231 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96II8 | LRCH3 | S611 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96PD5 | PGLYRP2 | S170 | ochoa | N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (Peptidoglycan recognition protein 2) (Peptidoglycan recognition protein long) (PGRP-L) | May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. {ECO:0000269|PubMed:14506276}. |
| Q96PE2 | ARHGEF17 | S79 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q99567 | NUP88 | S50 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q9BQI6 | SLF1 | S159 | ochoa | SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565, PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q9BTU6 | PI4K2A | S51 | ochoa|psp | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
| Q9BYE2 | TMPRSS13 | S135 | ochoa | Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) | Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity). {ECO:0000250|UniProtKB:Q5U405, ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451}. |
| Q9C0C7 | AMBRA1 | S1205 | ochoa | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250|UniProtKB:A2AH22, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24587252, ECO:0000269|PubMed:25215947, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25499913, ECO:0000269|PubMed:25803737, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32333458, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}. |
| Q9C0K0 | BCL11B | S169 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H0A8 | COMMD4 | S115 | ochoa | COMM domain-containing protein 4 | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}. |
| Q9H2Y7 | ZNF106 | S1328 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H4L7 | SMARCAD1 | S34 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9NQC1 | JADE2 | S672 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
| Q9NRL3 | STRN4 | S342 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
| Q9NS37 | CREBZF | S22 | ochoa | CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
| Q9NS37 | CREBZF | S50 | ochoa | CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
| Q9NTJ3 | SMC4 | S41 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NW08 | POLR3B | S680 | ochoa | DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) | Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558766). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Forms Pol III active center together with the largest subunit POLR3A/RPC1. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (PubMed:19609254, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33674783, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000269|PubMed:34675218}. |
| Q9NZJ9 | NUDT4 | S148 | ochoa | Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.61) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4) | Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q8R2U6, ECO:0000269|PubMed:10777568, ECO:0000269|PubMed:12370170}. |
| Q9NZN5 | ARHGEF12 | S635 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P227 | ARHGAP23 | S517 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P243 | ZFAT | S652 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
| Q9P2Y4 | ZNF219 | S698 | ochoa | Zinc finger protein 219 | Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}. |
| Q9UGU0 | TCF20 | S1122 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UK41 | VPS28 | S62 | ochoa | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}. |
| Q9UKN5 | PRDM4 | S202 | ochoa | PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) | May function as a transcription factor involved in cell differentiation. |
| Q9UNH5 | CDC14A | S453 | psp | Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}. |
| Q9UPQ9 | TNRC6B | S1432 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPV0 | CEP164 | S286 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y2J4 | AMOTL2 | S236 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2K7 | KDM2A | S832 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y485 | DMXL1 | S918 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y490 | TLN1 | S729 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B6 | DCAF1 | S1000 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4H2 | IRS2 | S620 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H2 | IRS2 | S1100 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4P8 | WIPI2 | S413 | ochoa|psp | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30968111}.; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. {ECO:0000269|PubMed:24954904}. |
| P11142 | HSPA8 | T38 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P34931 | HSPA1L | T40 | Sugiyama | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P54652 | HSPA2 | T39 | Sugiyama | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| Q8IWW6 | ARHGAP12 | S240 | Sugiyama | Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P05187 | ALPP | S438 | Sugiyama | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P10696 | ALPG | S435 | Sugiyama | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| P17066 | HSPA6 | T40 | Sugiyama | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P48741 | HSPA7 | T40 | Sugiyama | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P41279 | MAP3K8 | S358 | Sugiyama | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371571 | HSF1-dependent transactivation | 1.429222e-09 | 8.845 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.142176e-09 | 8.669 |
| R-HSA-3371556 | Cellular response to heat stress | 1.063322e-09 | 8.973 |
| R-HSA-3371568 | Attenuation phase | 5.185034e-09 | 8.285 |
| R-HSA-3371511 | HSF1 activation | 2.633101e-05 | 4.580 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.748605e-03 | 2.757 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.898141e-03 | 2.722 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.786529e-03 | 2.422 |
| R-HSA-2262752 | Cellular responses to stress | 3.401801e-03 | 2.468 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.050501e-03 | 2.392 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.995017e-03 | 2.301 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.550370e-03 | 2.184 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 7.094768e-03 | 2.149 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.916039e-03 | 2.050 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.039443e-02 | 1.983 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.209356e-02 | 1.917 |
| R-HSA-73887 | Death Receptor Signaling | 1.209356e-02 | 1.917 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 4.622663e-02 | 1.335 |
| R-HSA-74713 | IRS activation | 5.372221e-02 | 1.270 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 6.115935e-02 | 1.214 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 6.853849e-02 | 1.164 |
| R-HSA-112412 | SOS-mediated signalling | 7.586008e-02 | 1.120 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 8.312457e-02 | 1.080 |
| R-HSA-9613354 | Lipophagy | 9.033241e-02 | 1.044 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 9.748402e-02 | 1.011 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.958276e-02 | 1.708 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.958276e-02 | 1.708 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.045799e-01 | 0.981 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.116203e-01 | 0.952 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.186059e-01 | 0.926 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.159687e-02 | 1.500 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.324139e-01 | 0.878 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.392372e-01 | 0.856 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.392372e-01 | 0.856 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 1.392372e-01 | 0.856 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.460073e-01 | 0.836 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.593893e-01 | 0.798 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.660021e-01 | 0.780 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 1.790733e-01 | 0.747 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.790733e-01 | 0.747 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.046089e-01 | 0.689 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.414419e-01 | 0.617 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.474141e-01 | 0.607 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.136632e-01 | 0.944 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.533395e-01 | 0.596 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.533395e-01 | 0.596 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.650520e-01 | 0.577 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.650520e-01 | 0.577 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.708397e-01 | 0.567 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.822797e-01 | 0.549 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.879328e-01 | 0.541 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.046283e-01 | 0.516 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.101067e-01 | 0.508 |
| R-HSA-354192 | Integrin signaling | 2.650520e-01 | 0.577 |
| R-HSA-198203 | PI3K/AKT activation | 9.748402e-02 | 1.011 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.420893e-01 | 0.466 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.879328e-01 | 0.541 |
| R-HSA-9620244 | Long-term potentiation | 2.529527e-02 | 1.597 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 5.770998e-02 | 1.239 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.835465e-02 | 1.165 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.835465e-02 | 1.165 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.835465e-02 | 1.165 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.046283e-01 | 0.516 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.472748e-01 | 0.459 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 5.372221e-02 | 1.270 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 5.372221e-02 | 1.270 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.324139e-01 | 0.878 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.935417e-01 | 0.532 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.209353e-01 | 0.494 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.672438e-01 | 0.777 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.232420e-01 | 0.651 |
| R-HSA-525793 | Myogenesis | 2.232420e-01 | 0.651 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 9.033241e-02 | 1.044 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.835465e-02 | 1.165 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 3.105830e-02 | 1.508 |
| R-HSA-8875513 | MET interacts with TNS proteins | 3.867215e-02 | 1.413 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.958276e-02 | 1.708 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.255369e-01 | 0.901 |
| R-HSA-964975 | Vitamin B6 activation to pyridoxal phosphate | 1.527245e-01 | 0.816 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.919412e-01 | 0.717 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.919412e-01 | 0.717 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 1.982999e-01 | 0.703 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.982999e-01 | 0.703 |
| R-HSA-9839394 | TGFBR3 expression | 2.170796e-01 | 0.663 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.354228e-01 | 0.628 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.414419e-01 | 0.617 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.533395e-01 | 0.596 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.879328e-01 | 0.541 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.935417e-01 | 0.532 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.420893e-01 | 0.466 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.660021e-01 | 0.780 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.474141e-01 | 0.607 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.474141e-01 | 0.607 |
| R-HSA-74749 | Signal attenuation | 9.748402e-02 | 1.011 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.392372e-01 | 0.856 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.324139e-01 | 0.878 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.982999e-01 | 0.703 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 1.982999e-01 | 0.703 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.708397e-01 | 0.567 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.272837e-02 | 1.643 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.236271e-02 | 1.650 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.116203e-01 | 0.952 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.593893e-01 | 0.798 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.644656e-01 | 0.784 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 9.748402e-02 | 1.011 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.844606e-02 | 1.415 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.790733e-01 | 0.747 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.765821e-01 | 0.558 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.420893e-01 | 0.466 |
| R-HSA-182971 | EGFR downregulation | 2.533395e-01 | 0.596 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.077833e-02 | 1.216 |
| R-HSA-68875 | Mitotic Prophase | 2.852191e-01 | 0.545 |
| R-HSA-425381 | Bicarbonate transporters | 1.045799e-01 | 0.981 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.116203e-01 | 0.952 |
| R-HSA-446205 | Synthesis of GDP-mannose | 1.186059e-01 | 0.926 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.255369e-01 | 0.901 |
| R-HSA-445355 | Smooth Muscle Contraction | 8.423088e-02 | 1.075 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 9.618519e-02 | 1.017 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.533395e-01 | 0.596 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.101067e-01 | 0.508 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.101067e-01 | 0.508 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.155422e-01 | 0.501 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.494701e-01 | 0.603 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.756264e-01 | 0.755 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.293563e-01 | 0.639 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.155422e-01 | 0.501 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 6.115935e-02 | 1.214 |
| R-HSA-447041 | CHL1 interactions | 7.586008e-02 | 1.120 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 8.312457e-02 | 1.080 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.186059e-01 | 0.926 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.186059e-01 | 0.926 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.186059e-01 | 0.926 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.392372e-01 | 0.856 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.770998e-02 | 1.239 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 1.855324e-01 | 0.732 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.108687e-01 | 0.676 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.474141e-01 | 0.607 |
| R-HSA-3214847 | HATs acetylate histones | 5.700422e-02 | 1.244 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.708397e-01 | 0.567 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.452735e-01 | 0.838 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.991067e-01 | 0.524 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.472748e-01 | 0.459 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.557872e-02 | 1.122 |
| R-HSA-9612973 | Autophagy | 4.968344e-02 | 1.304 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.593893e-01 | 0.798 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.770120e-01 | 0.558 |
| R-HSA-177929 | Signaling by EGFR | 1.452163e-02 | 1.838 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.101067e-01 | 0.508 |
| R-HSA-111933 | Calmodulin induced events | 2.879328e-01 | 0.541 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.472748e-01 | 0.459 |
| R-HSA-199991 | Membrane Trafficking | 2.768163e-01 | 0.558 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.527245e-01 | 0.816 |
| R-HSA-111997 | CaM pathway | 2.879328e-01 | 0.541 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.046283e-01 | 0.516 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.822797e-01 | 0.549 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.170796e-01 | 0.663 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.155422e-01 | 0.501 |
| R-HSA-9909396 | Circadian clock | 3.257787e-01 | 0.487 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.170796e-01 | 0.663 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.170796e-01 | 0.663 |
| R-HSA-111996 | Ca-dependent events | 3.262862e-01 | 0.486 |
| R-HSA-373752 | Netrin-1 signaling | 3.368629e-01 | 0.473 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.863297e-01 | 0.543 |
| R-HSA-447043 | Neurofascin interactions | 6.853849e-02 | 1.164 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.324139e-01 | 0.878 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.527245e-01 | 0.816 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.414419e-01 | 0.617 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.420893e-01 | 0.466 |
| R-HSA-2028269 | Signaling by Hippo | 1.593893e-01 | 0.798 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.278818e-01 | 0.642 |
| R-HSA-397014 | Muscle contraction | 1.121325e-01 | 0.950 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.026518e-01 | 0.519 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.026518e-01 | 0.519 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.392372e-01 | 0.856 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.460073e-01 | 0.836 |
| R-HSA-175474 | Assembly Of The HIV Virion | 1.919412e-01 | 0.717 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 2.046089e-01 | 0.689 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.398817e-01 | 0.854 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.879328e-01 | 0.541 |
| R-HSA-1632852 | Macroautophagy | 1.298267e-01 | 0.887 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.026518e-01 | 0.519 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.396717e-01 | 0.620 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.650520e-01 | 0.577 |
| R-HSA-3214842 | HDMs demethylate histones | 2.170796e-01 | 0.663 |
| R-HSA-5578775 | Ion homeostasis | 9.134661e-02 | 1.039 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.155422e-01 | 0.501 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.328448e-01 | 0.633 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.328448e-01 | 0.633 |
| R-HSA-8876725 | Protein methylation | 1.392372e-01 | 0.856 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.592187e-01 | 0.586 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.650520e-01 | 0.577 |
| R-HSA-112310 | Neurotransmitter release cycle | 1.840749e-01 | 0.735 |
| R-HSA-2586552 | Signaling by Leptin | 9.748402e-02 | 1.011 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.527369e-02 | 1.344 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.392372e-01 | 0.856 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.644656e-01 | 0.784 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 1.450290e-02 | 1.839 |
| R-HSA-180292 | GAB1 signalosome | 1.660021e-01 | 0.780 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.232420e-01 | 0.651 |
| R-HSA-5576891 | Cardiac conduction | 3.228973e-01 | 0.491 |
| R-HSA-4839726 | Chromatin organization | 2.032756e-02 | 1.692 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.790733e-01 | 0.747 |
| R-HSA-5673000 | RAF activation | 2.765821e-01 | 0.558 |
| R-HSA-8875878 | MET promotes cell motility | 2.991067e-01 | 0.524 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.357456e-01 | 0.628 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.181158e-01 | 0.497 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.401366e-01 | 0.468 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.919412e-01 | 0.717 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.170796e-01 | 0.663 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.368629e-01 | 0.473 |
| R-HSA-211000 | Gene Silencing by RNA | 2.415532e-01 | 0.617 |
| R-HSA-373755 | Semaphorin interactions | 1.085881e-01 | 0.964 |
| R-HSA-5693538 | Homology Directed Repair | 2.793980e-01 | 0.554 |
| R-HSA-8854214 | TBC/RABGAPs | 3.315953e-01 | 0.479 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.150809e-02 | 1.288 |
| R-HSA-1640170 | Cell Cycle | 2.184366e-01 | 0.661 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 1.725633e-01 | 0.763 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.232420e-01 | 0.651 |
| R-HSA-9833482 | PKR-mediated signaling | 3.298866e-02 | 1.482 |
| R-HSA-189451 | Heme biosynthesis | 3.209353e-01 | 0.494 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.991067e-01 | 0.524 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.478452e-01 | 0.830 |
| R-HSA-422475 | Axon guidance | 1.608364e-01 | 0.794 |
| R-HSA-8853659 | RET signaling | 2.879328e-01 | 0.541 |
| R-HSA-9675108 | Nervous system development | 1.997096e-01 | 0.700 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.134241e-01 | 0.945 |
| R-HSA-913531 | Interferon Signaling | 1.012277e-01 | 0.995 |
| R-HSA-6806834 | Signaling by MET | 1.534409e-01 | 0.814 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.170796e-01 | 0.663 |
| R-HSA-373760 | L1CAM interactions | 2.735740e-01 | 0.563 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.046089e-01 | 0.689 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.728245e-01 | 0.762 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.897400e-01 | 0.722 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.046283e-01 | 0.516 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.487077e-01 | 0.458 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.524198e-01 | 0.453 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.575245e-01 | 0.447 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.575245e-01 | 0.447 |
| R-HSA-9609646 | HCMV Infection | 3.585958e-01 | 0.445 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.600783e-01 | 0.444 |
| R-HSA-9766229 | Degradation of CDH1 | 3.625893e-01 | 0.441 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.625893e-01 | 0.441 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.629099e-01 | 0.440 |
| R-HSA-109704 | PI3K Cascade | 3.676145e-01 | 0.435 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.726004e-01 | 0.429 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.775472e-01 | 0.423 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.775472e-01 | 0.423 |
| R-HSA-1221632 | Meiotic synapsis | 3.824554e-01 | 0.417 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.824554e-01 | 0.417 |
| R-HSA-8956320 | Nucleotide biosynthesis | 3.824554e-01 | 0.417 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.840491e-01 | 0.416 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.909566e-01 | 0.408 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.921569e-01 | 0.407 |
| R-HSA-68886 | M Phase | 3.931536e-01 | 0.405 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.937322e-01 | 0.405 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.969507e-01 | 0.401 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.969507e-01 | 0.401 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.969507e-01 | 0.401 |
| R-HSA-112399 | IRS-mediated signalling | 4.017071e-01 | 0.396 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.017071e-01 | 0.396 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.017071e-01 | 0.396 |
| R-HSA-9610379 | HCMV Late Events | 4.020249e-01 | 0.396 |
| R-HSA-162587 | HIV Life Cycle | 4.020249e-01 | 0.396 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.102647e-01 | 0.387 |
| R-HSA-191859 | snRNP Assembly | 4.111084e-01 | 0.386 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.111084e-01 | 0.386 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.111084e-01 | 0.386 |
| R-HSA-983189 | Kinesins | 4.157540e-01 | 0.381 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.157540e-01 | 0.381 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.157540e-01 | 0.381 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.157540e-01 | 0.381 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.157540e-01 | 0.381 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.157540e-01 | 0.381 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.162102e-01 | 0.381 |
| R-HSA-446728 | Cell junction organization | 4.180983e-01 | 0.379 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.201953e-01 | 0.377 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.203632e-01 | 0.376 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.203632e-01 | 0.376 |
| R-HSA-450294 | MAP kinase activation | 4.203632e-01 | 0.376 |
| R-HSA-112043 | PLC beta mediated events | 4.203632e-01 | 0.376 |
| R-HSA-9707616 | Heme signaling | 4.249363e-01 | 0.372 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.249363e-01 | 0.372 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.249363e-01 | 0.372 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.294736e-01 | 0.367 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.294736e-01 | 0.367 |
| R-HSA-8848021 | Signaling by PTK6 | 4.294736e-01 | 0.367 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.294736e-01 | 0.367 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.339754e-01 | 0.363 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.339754e-01 | 0.363 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.339754e-01 | 0.363 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.384420e-01 | 0.358 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.384420e-01 | 0.358 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.428736e-01 | 0.354 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.472704e-01 | 0.349 |
| R-HSA-112040 | G-protein mediated events | 4.472704e-01 | 0.349 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.479602e-01 | 0.349 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.479602e-01 | 0.349 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.516329e-01 | 0.345 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.516329e-01 | 0.345 |
| R-HSA-448424 | Interleukin-17 signaling | 4.602556e-01 | 0.337 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.602556e-01 | 0.337 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.645164e-01 | 0.333 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.645164e-01 | 0.333 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.645164e-01 | 0.333 |
| R-HSA-189445 | Metabolism of porphyrins | 4.645164e-01 | 0.333 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.687438e-01 | 0.329 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.687438e-01 | 0.329 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.687438e-01 | 0.329 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.729380e-01 | 0.325 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.729380e-01 | 0.325 |
| R-HSA-4086398 | Ca2+ pathway | 4.729380e-01 | 0.325 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.770995e-01 | 0.321 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.770995e-01 | 0.321 |
| R-HSA-380287 | Centrosome maturation | 4.812283e-01 | 0.318 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.812283e-01 | 0.318 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.816940e-01 | 0.317 |
| R-HSA-69275 | G2/M Transition | 4.817405e-01 | 0.317 |
| R-HSA-5689603 | UCH proteinases | 4.853248e-01 | 0.314 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.853248e-01 | 0.314 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.868256e-01 | 0.313 |
| R-HSA-983712 | Ion channel transport | 4.893567e-01 | 0.310 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.934217e-01 | 0.307 |
| R-HSA-4086400 | PCP/CE pathway | 4.934217e-01 | 0.307 |
| R-HSA-1500931 | Cell-Cell communication | 4.957342e-01 | 0.305 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.969034e-01 | 0.304 |
| R-HSA-9659379 | Sensory processing of sound | 4.974226e-01 | 0.303 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.985608e-01 | 0.302 |
| R-HSA-68877 | Mitotic Prometaphase | 4.994034e-01 | 0.302 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.013922e-01 | 0.300 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.018955e-01 | 0.299 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.053307e-01 | 0.296 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.053307e-01 | 0.296 |
| R-HSA-9609690 | HCMV Early Events | 5.068560e-01 | 0.295 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.068560e-01 | 0.295 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.092383e-01 | 0.293 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.131153e-01 | 0.290 |
| R-HSA-1500620 | Meiosis | 5.207783e-01 | 0.283 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.207783e-01 | 0.283 |
| R-HSA-6798695 | Neutrophil degranulation | 5.227183e-01 | 0.282 |
| R-HSA-72172 | mRNA Splicing | 5.287815e-01 | 0.277 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.357472e-01 | 0.271 |
| R-HSA-9663891 | Selective autophagy | 5.357472e-01 | 0.271 |
| R-HSA-112316 | Neuronal System | 5.406991e-01 | 0.267 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.430568e-01 | 0.265 |
| R-HSA-73884 | Base Excision Repair | 5.430568e-01 | 0.265 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.458332e-01 | 0.263 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.466686e-01 | 0.262 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.538076e-01 | 0.257 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.538076e-01 | 0.257 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.608349e-01 | 0.251 |
| R-HSA-418990 | Adherens junctions interactions | 5.615672e-01 | 0.251 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.711706e-01 | 0.243 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.711706e-01 | 0.243 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.745619e-01 | 0.241 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.779266e-01 | 0.238 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.779266e-01 | 0.238 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.779266e-01 | 0.238 |
| R-HSA-422356 | Regulation of insulin secretion | 5.779266e-01 | 0.238 |
| R-HSA-73894 | DNA Repair | 5.787994e-01 | 0.237 |
| R-HSA-162906 | HIV Infection | 5.817774e-01 | 0.235 |
| R-HSA-70171 | Glycolysis | 5.845770e-01 | 0.233 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.878631e-01 | 0.231 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.911235e-01 | 0.228 |
| R-HSA-1483255 | PI Metabolism | 5.911235e-01 | 0.228 |
| R-HSA-1266738 | Developmental Biology | 5.965295e-01 | 0.224 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.975675e-01 | 0.224 |
| R-HSA-111885 | Opioid Signalling | 5.975675e-01 | 0.224 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.975675e-01 | 0.224 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 6.007517e-01 | 0.221 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.039108e-01 | 0.219 |
| R-HSA-157118 | Signaling by NOTCH | 6.097592e-01 | 0.215 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.101549e-01 | 0.215 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.101549e-01 | 0.215 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.132402e-01 | 0.212 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.132402e-01 | 0.212 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.163013e-01 | 0.210 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.193383e-01 | 0.208 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.193383e-01 | 0.208 |
| R-HSA-6803157 | Antimicrobial peptides | 6.223515e-01 | 0.206 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.283071e-01 | 0.202 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.283071e-01 | 0.202 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.312499e-01 | 0.200 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.312499e-01 | 0.200 |
| R-HSA-421270 | Cell-cell junction organization | 6.323173e-01 | 0.199 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.370662e-01 | 0.196 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.370662e-01 | 0.196 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.399402e-01 | 0.194 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.422334e-01 | 0.192 |
| R-HSA-70326 | Glucose metabolism | 6.456205e-01 | 0.190 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.456205e-01 | 0.190 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.456205e-01 | 0.190 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.484272e-01 | 0.188 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.512119e-01 | 0.186 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.512119e-01 | 0.186 |
| R-HSA-416476 | G alpha (q) signalling events | 6.576636e-01 | 0.182 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.594353e-01 | 0.181 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.594353e-01 | 0.181 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.621335e-01 | 0.179 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.621335e-01 | 0.179 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.648104e-01 | 0.177 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.648104e-01 | 0.177 |
| R-HSA-194138 | Signaling by VEGF | 6.701014e-01 | 0.174 |
| R-HSA-114608 | Platelet degranulation | 6.753094e-01 | 0.170 |
| R-HSA-69481 | G2/M Checkpoints | 6.753094e-01 | 0.170 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.778828e-01 | 0.169 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.829689e-01 | 0.166 |
| R-HSA-1474165 | Reproduction | 6.854821e-01 | 0.164 |
| R-HSA-9843745 | Adipogenesis | 6.879754e-01 | 0.162 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 6.879754e-01 | 0.162 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.904491e-01 | 0.161 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.904492e-01 | 0.161 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.929034e-01 | 0.159 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.025290e-01 | 0.153 |
| R-HSA-163685 | Integration of energy metabolism | 7.025290e-01 | 0.153 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.048883e-01 | 0.152 |
| R-HSA-6807070 | PTEN Regulation | 7.095512e-01 | 0.149 |
| R-HSA-162582 | Signal Transduction | 7.124893e-01 | 0.147 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.125027e-01 | 0.147 |
| R-HSA-195721 | Signaling by WNT | 7.174031e-01 | 0.144 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.186589e-01 | 0.143 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.317918e-01 | 0.136 |
| R-HSA-166520 | Signaling by NTRKs | 7.317918e-01 | 0.136 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.402073e-01 | 0.131 |
| R-HSA-69306 | DNA Replication | 7.422699e-01 | 0.129 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.463465e-01 | 0.127 |
| R-HSA-1989781 | PPARA activates gene expression | 7.463465e-01 | 0.127 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.503591e-01 | 0.125 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 7.503591e-01 | 0.125 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.512473e-01 | 0.124 |
| R-HSA-449147 | Signaling by Interleukins | 7.538151e-01 | 0.123 |
| R-HSA-877300 | Interferon gamma signaling | 7.543088e-01 | 0.122 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.555846e-01 | 0.122 |
| R-HSA-388396 | GPCR downstream signalling | 7.564444e-01 | 0.121 |
| R-HSA-5619102 | SLC transporter disorders | 7.694969e-01 | 0.114 |
| R-HSA-72306 | tRNA processing | 7.767378e-01 | 0.110 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.802732e-01 | 0.108 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.854723e-01 | 0.105 |
| R-HSA-168255 | Influenza Infection | 7.922152e-01 | 0.101 |
| R-HSA-2559583 | Cellular Senescence | 7.938678e-01 | 0.100 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.074780e-01 | 0.093 |
| R-HSA-5617833 | Cilium Assembly | 8.096930e-01 | 0.092 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.112076e-01 | 0.091 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.243121e-01 | 0.084 |
| R-HSA-372790 | Signaling by GPCR | 8.276801e-01 | 0.082 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.306333e-01 | 0.081 |
| R-HSA-6805567 | Keratinization | 8.338770e-01 | 0.079 |
| R-HSA-8951664 | Neddylation | 8.526682e-01 | 0.069 |
| R-HSA-168256 | Immune System | 8.567091e-01 | 0.067 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.584507e-01 | 0.066 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.607002e-01 | 0.065 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.629141e-01 | 0.064 |
| R-HSA-15869 | Metabolism of nucleotides | 8.693487e-01 | 0.061 |
| R-HSA-8939211 | ESR-mediated signaling | 8.703916e-01 | 0.060 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.803769e-01 | 0.055 |
| R-HSA-5688426 | Deubiquitination | 8.878125e-01 | 0.052 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.904810e-01 | 0.050 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.989293e-01 | 0.046 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.036845e-01 | 0.044 |
| R-HSA-8953854 | Metabolism of RNA | 9.103284e-01 | 0.041 |
| R-HSA-168249 | Innate Immune System | 9.151836e-01 | 0.038 |
| R-HSA-1483257 | Phospholipid metabolism | 9.186456e-01 | 0.037 |
| R-HSA-1280218 | Adaptive Immune System | 9.286110e-01 | 0.032 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.473487e-01 | 0.023 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.533554e-01 | 0.021 |
| R-HSA-597592 | Post-translational protein modification | 9.607193e-01 | 0.017 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.625043e-01 | 0.017 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.645700e-01 | 0.016 |
| R-HSA-418594 | G alpha (i) signalling events | 9.673265e-01 | 0.014 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.710672e-01 | 0.013 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.778670e-01 | 0.010 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.795951e-01 | 0.009 |
| R-HSA-9824446 | Viral Infection Pathways | 9.826130e-01 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 9.872234e-01 | 0.006 |
| R-HSA-109582 | Hemostasis | 9.885985e-01 | 0.005 |
| R-HSA-9679506 | SARS-CoV Infections | 9.902061e-01 | 0.004 |
| R-HSA-74160 | Gene expression (Transcription) | 9.968185e-01 | 0.001 |
| R-HSA-5663205 | Infectious disease | 9.982567e-01 | 0.001 |
| R-HSA-212436 | Generic Transcription Pathway | 9.988622e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.993155e-01 | 0.000 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.995729e-01 | 0.000 |
| R-HSA-1643685 | Disease | 9.998471e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999471e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999674e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999997e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.853 | 0.817 | 1 | 0.806 |
P38G |
0.837 | 0.837 | 1 | 0.864 |
CDK19 |
0.835 | 0.806 | 1 | 0.813 |
CDK18 |
0.835 | 0.808 | 1 | 0.820 |
KIS |
0.834 | 0.737 | 1 | 0.750 |
DYRK4 |
0.833 | 0.789 | 1 | 0.818 |
CDK17 |
0.832 | 0.814 | 1 | 0.850 |
JNK2 |
0.831 | 0.833 | 1 | 0.821 |
CDK8 |
0.831 | 0.805 | 1 | 0.777 |
DYRK2 |
0.830 | 0.784 | 1 | 0.720 |
P38D |
0.829 | 0.813 | 1 | 0.863 |
ERK1 |
0.829 | 0.813 | 1 | 0.811 |
CDK3 |
0.827 | 0.708 | 1 | 0.843 |
P38B |
0.827 | 0.821 | 1 | 0.794 |
CDK1 |
0.827 | 0.778 | 1 | 0.796 |
HIPK1 |
0.825 | 0.743 | 1 | 0.699 |
CDK7 |
0.823 | 0.790 | 1 | 0.772 |
CDK16 |
0.822 | 0.775 | 1 | 0.834 |
JNK3 |
0.821 | 0.817 | 1 | 0.794 |
HIPK4 |
0.820 | 0.589 | 1 | 0.494 |
CDK10 |
0.818 | 0.751 | 1 | 0.792 |
CDK5 |
0.818 | 0.754 | 1 | 0.741 |
DYRK1B |
0.818 | 0.752 | 1 | 0.768 |
CDK12 |
0.817 | 0.779 | 1 | 0.818 |
P38A |
0.816 | 0.799 | 1 | 0.720 |
DYRK1A |
0.816 | 0.699 | 1 | 0.677 |
CDK13 |
0.816 | 0.770 | 1 | 0.794 |
CDK14 |
0.816 | 0.785 | 1 | 0.776 |
HIPK3 |
0.812 | 0.727 | 1 | 0.674 |
CDK9 |
0.811 | 0.765 | 1 | 0.790 |
MAK |
0.810 | 0.631 | -2 | 0.889 |
CLK3 |
0.810 | 0.509 | 1 | 0.459 |
JNK1 |
0.810 | 0.752 | 1 | 0.818 |
ERK2 |
0.806 | 0.779 | 1 | 0.753 |
DYRK3 |
0.805 | 0.618 | 1 | 0.664 |
CLK2 |
0.804 | 0.482 | -3 | 0.855 |
SRPK1 |
0.802 | 0.420 | -3 | 0.875 |
CDK4 |
0.802 | 0.768 | 1 | 0.824 |
NLK |
0.800 | 0.716 | 1 | 0.500 |
CDK6 |
0.798 | 0.731 | 1 | 0.799 |
CLK1 |
0.798 | 0.484 | -3 | 0.840 |
CLK4 |
0.795 | 0.461 | -3 | 0.858 |
ICK |
0.792 | 0.500 | -3 | 0.910 |
CDKL5 |
0.791 | 0.322 | -3 | 0.899 |
MOK |
0.790 | 0.569 | 1 | 0.586 |
SRPK2 |
0.790 | 0.360 | -3 | 0.820 |
CDK2 |
0.788 | 0.575 | 1 | 0.670 |
ERK5 |
0.788 | 0.394 | 1 | 0.422 |
CDKL1 |
0.785 | 0.305 | -3 | 0.897 |
SRPK3 |
0.780 | 0.324 | -3 | 0.848 |
MTOR |
0.778 | 0.230 | 1 | 0.298 |
PRP4 |
0.772 | 0.443 | -3 | 0.744 |
MOS |
0.771 | 0.093 | 1 | 0.154 |
COT |
0.769 | -0.055 | 2 | 0.774 |
ERK7 |
0.765 | 0.282 | 2 | 0.553 |
CDC7 |
0.764 | -0.060 | 1 | 0.115 |
CAMK1B |
0.762 | 0.068 | -3 | 0.895 |
PIM3 |
0.761 | 0.044 | -3 | 0.894 |
PRPK |
0.760 | -0.060 | -1 | 0.687 |
PKN3 |
0.760 | 0.042 | -3 | 0.888 |
ATR |
0.760 | -0.018 | 1 | 0.157 |
PRKD1 |
0.760 | 0.059 | -3 | 0.889 |
NUAK2 |
0.759 | 0.071 | -3 | 0.883 |
MST4 |
0.758 | -0.006 | 2 | 0.788 |
RSK2 |
0.757 | 0.083 | -3 | 0.871 |
SKMLCK |
0.757 | 0.028 | -2 | 0.835 |
GRK1 |
0.757 | 0.035 | -2 | 0.766 |
TBK1 |
0.757 | -0.142 | 1 | 0.096 |
PRKD2 |
0.756 | 0.080 | -3 | 0.851 |
CAMLCK |
0.756 | 0.074 | -2 | 0.812 |
WNK1 |
0.755 | -0.038 | -2 | 0.823 |
NDR2 |
0.755 | 0.022 | -3 | 0.871 |
AURC |
0.754 | 0.069 | -2 | 0.665 |
PKN2 |
0.754 | 0.004 | -3 | 0.869 |
IKKE |
0.753 | -0.151 | 1 | 0.097 |
RAF1 |
0.753 | -0.152 | 1 | 0.105 |
IKKB |
0.753 | -0.134 | -2 | 0.665 |
CHAK2 |
0.753 | -0.041 | -1 | 0.661 |
RSK3 |
0.753 | 0.070 | -3 | 0.871 |
PIM1 |
0.752 | 0.089 | -3 | 0.866 |
P90RSK |
0.752 | 0.077 | -3 | 0.881 |
DAPK2 |
0.752 | 0.050 | -3 | 0.890 |
NIK |
0.752 | -0.012 | -3 | 0.875 |
BMPR2 |
0.751 | -0.168 | -2 | 0.799 |
GCN2 |
0.751 | -0.175 | 2 | 0.710 |
AMPKA1 |
0.751 | -0.006 | -3 | 0.878 |
NDR1 |
0.750 | 0.004 | -3 | 0.877 |
MAPKAPK2 |
0.750 | 0.060 | -3 | 0.835 |
AKT2 |
0.750 | 0.133 | -3 | 0.812 |
PKACG |
0.749 | 0.032 | -2 | 0.705 |
PKCD |
0.749 | 0.005 | 2 | 0.705 |
AMPKA2 |
0.749 | 0.022 | -3 | 0.866 |
BMPR1B |
0.749 | -0.030 | 1 | 0.091 |
P70S6KB |
0.749 | 0.063 | -3 | 0.868 |
GRK7 |
0.748 | 0.014 | 1 | 0.135 |
MAPKAPK3 |
0.748 | 0.027 | -3 | 0.851 |
MPSK1 |
0.748 | 0.106 | 1 | 0.172 |
PAK1 |
0.748 | 0.024 | -2 | 0.788 |
PKACB |
0.747 | 0.096 | -2 | 0.660 |
PDHK4 |
0.747 | -0.194 | 1 | 0.173 |
TGFBR2 |
0.747 | -0.086 | -2 | 0.742 |
MLK1 |
0.747 | -0.114 | 2 | 0.749 |
PRKD3 |
0.747 | 0.078 | -3 | 0.841 |
MARK4 |
0.747 | -0.040 | 4 | 0.807 |
DSTYK |
0.746 | -0.167 | 2 | 0.799 |
ULK2 |
0.746 | -0.214 | 2 | 0.709 |
RIPK3 |
0.745 | -0.110 | 3 | 0.708 |
SGK3 |
0.745 | 0.073 | -3 | 0.851 |
NEK6 |
0.745 | -0.112 | -2 | 0.756 |
CAMK2G |
0.744 | -0.105 | 2 | 0.675 |
RSK4 |
0.744 | 0.083 | -3 | 0.851 |
IRE1 |
0.744 | -0.082 | 1 | 0.104 |
GSK3A |
0.743 | 0.183 | 4 | 0.388 |
TSSK1 |
0.743 | -0.016 | -3 | 0.889 |
PKCB |
0.743 | 0.006 | 2 | 0.683 |
PAK6 |
0.743 | 0.042 | -2 | 0.701 |
PAK3 |
0.742 | -0.013 | -2 | 0.770 |
PDHK1 |
0.742 | -0.201 | 1 | 0.155 |
MNK2 |
0.742 | -0.002 | -2 | 0.750 |
PKCA |
0.742 | 0.009 | 2 | 0.672 |
MLK3 |
0.742 | -0.047 | 2 | 0.685 |
LATS1 |
0.741 | 0.030 | -3 | 0.874 |
MLK2 |
0.741 | -0.099 | 2 | 0.751 |
HUNK |
0.741 | -0.159 | 2 | 0.731 |
TGFBR1 |
0.741 | -0.044 | -2 | 0.744 |
TSSK2 |
0.741 | -0.062 | -5 | 0.854 |
PRKX |
0.741 | 0.104 | -3 | 0.782 |
PHKG1 |
0.741 | -0.010 | -3 | 0.857 |
MSK2 |
0.740 | 0.058 | -3 | 0.853 |
WNK3 |
0.740 | -0.167 | 1 | 0.108 |
PKCG |
0.740 | -0.008 | 2 | 0.680 |
PKG2 |
0.740 | 0.044 | -2 | 0.656 |
NIM1 |
0.740 | -0.057 | 3 | 0.756 |
ATM |
0.740 | -0.076 | 1 | 0.125 |
AURB |
0.739 | 0.037 | -2 | 0.656 |
NEK7 |
0.739 | -0.204 | -3 | 0.783 |
DLK |
0.739 | -0.150 | 1 | 0.125 |
IKKA |
0.739 | -0.107 | -2 | 0.659 |
GRK5 |
0.738 | -0.171 | -3 | 0.810 |
PKCZ |
0.738 | -0.019 | 2 | 0.730 |
MYLK4 |
0.738 | 0.048 | -2 | 0.755 |
QSK |
0.738 | 0.012 | 4 | 0.785 |
MNK1 |
0.738 | -0.001 | -2 | 0.756 |
DNAPK |
0.737 | -0.055 | 1 | 0.154 |
AURA |
0.737 | 0.038 | -2 | 0.644 |
ALK4 |
0.737 | -0.069 | -2 | 0.769 |
VRK2 |
0.737 | 0.030 | 1 | 0.213 |
MSK1 |
0.736 | 0.063 | -3 | 0.857 |
MASTL |
0.736 | -0.167 | -2 | 0.734 |
PKR |
0.736 | -0.075 | 1 | 0.121 |
PIM2 |
0.736 | 0.091 | -3 | 0.850 |
TTBK2 |
0.736 | -0.167 | 2 | 0.668 |
MELK |
0.736 | -0.021 | -3 | 0.856 |
AKT1 |
0.736 | 0.095 | -3 | 0.817 |
NUAK1 |
0.735 | 0.008 | -3 | 0.852 |
CAMK4 |
0.735 | -0.061 | -3 | 0.847 |
PKCH |
0.735 | -0.024 | 2 | 0.666 |
BRSK1 |
0.735 | 0.003 | -3 | 0.854 |
RIPK1 |
0.735 | -0.169 | 1 | 0.099 |
CAMK2D |
0.735 | -0.089 | -3 | 0.867 |
PINK1 |
0.735 | 0.118 | 1 | 0.313 |
BCKDK |
0.734 | -0.165 | -1 | 0.603 |
PAK2 |
0.734 | -0.019 | -2 | 0.768 |
SIK |
0.734 | 0.021 | -3 | 0.826 |
LATS2 |
0.734 | -0.045 | -5 | 0.707 |
ULK1 |
0.734 | -0.207 | -3 | 0.779 |
GRK6 |
0.734 | -0.142 | 1 | 0.103 |
ACVR2B |
0.733 | -0.070 | -2 | 0.736 |
CAMK1G |
0.733 | 0.033 | -3 | 0.844 |
NEK9 |
0.733 | -0.207 | 2 | 0.770 |
QIK |
0.733 | -0.062 | -3 | 0.847 |
CAMK2A |
0.733 | -0.004 | 2 | 0.656 |
ANKRD3 |
0.732 | -0.182 | 1 | 0.127 |
MST3 |
0.732 | -0.023 | 2 | 0.793 |
MARK3 |
0.732 | -0.012 | 4 | 0.761 |
ACVR2A |
0.731 | -0.088 | -2 | 0.726 |
DCAMKL1 |
0.731 | 0.007 | -3 | 0.844 |
YSK4 |
0.731 | -0.160 | 1 | 0.098 |
CHAK1 |
0.731 | -0.137 | 2 | 0.740 |
SMG1 |
0.731 | -0.086 | 1 | 0.143 |
IRE2 |
0.731 | -0.104 | 2 | 0.682 |
BRSK2 |
0.731 | -0.044 | -3 | 0.847 |
PKACA |
0.731 | 0.082 | -2 | 0.617 |
MEK1 |
0.730 | -0.137 | 2 | 0.757 |
DRAK1 |
0.730 | -0.097 | 1 | 0.082 |
MLK4 |
0.729 | -0.100 | 2 | 0.666 |
FAM20C |
0.729 | -0.035 | 2 | 0.528 |
SGK1 |
0.729 | 0.135 | -3 | 0.765 |
ALK2 |
0.729 | -0.079 | -2 | 0.748 |
BMPR1A |
0.729 | -0.056 | 1 | 0.084 |
CK1E |
0.728 | -0.003 | -3 | 0.483 |
CAMK2B |
0.728 | -0.054 | 2 | 0.637 |
NEK2 |
0.728 | -0.153 | 2 | 0.767 |
PLK1 |
0.727 | -0.158 | -2 | 0.709 |
PKCE |
0.727 | 0.047 | 2 | 0.676 |
AKT3 |
0.727 | 0.112 | -3 | 0.777 |
GRK4 |
0.726 | -0.182 | -2 | 0.767 |
TLK2 |
0.726 | -0.144 | 1 | 0.096 |
PASK |
0.726 | 0.020 | -3 | 0.889 |
SBK |
0.726 | 0.206 | -3 | 0.726 |
TAO3 |
0.726 | -0.040 | 1 | 0.142 |
WNK4 |
0.726 | -0.092 | -2 | 0.806 |
PAK5 |
0.726 | 0.019 | -2 | 0.652 |
MARK2 |
0.726 | -0.034 | 4 | 0.730 |
PKCT |
0.725 | -0.017 | 2 | 0.668 |
MAPKAPK5 |
0.725 | -0.002 | -3 | 0.826 |
SSTK |
0.725 | -0.031 | 4 | 0.778 |
SMMLCK |
0.724 | 0.038 | -3 | 0.880 |
BUB1 |
0.724 | 0.039 | -5 | 0.811 |
MEK5 |
0.724 | -0.136 | 2 | 0.749 |
GSK3B |
0.724 | 0.037 | 4 | 0.377 |
GRK2 |
0.724 | -0.085 | -2 | 0.665 |
PKCI |
0.724 | -0.000 | 2 | 0.707 |
PHKG2 |
0.724 | -0.031 | -3 | 0.838 |
SNRK |
0.723 | -0.103 | 2 | 0.613 |
MEKK3 |
0.723 | -0.149 | 1 | 0.119 |
PAK4 |
0.722 | 0.030 | -2 | 0.665 |
GAK |
0.722 | -0.013 | 1 | 0.157 |
DCAMKL2 |
0.722 | -0.022 | -3 | 0.854 |
PKN1 |
0.722 | 0.044 | -3 | 0.824 |
PDK1 |
0.722 | -0.014 | 1 | 0.153 |
MEKK2 |
0.722 | -0.131 | 2 | 0.733 |
MARK1 |
0.721 | -0.051 | 4 | 0.772 |
PLK4 |
0.721 | -0.154 | 2 | 0.552 |
PERK |
0.720 | -0.162 | -2 | 0.765 |
P70S6K |
0.720 | 0.038 | -3 | 0.821 |
ZAK |
0.720 | -0.176 | 1 | 0.116 |
CK1D |
0.720 | 0.007 | -3 | 0.433 |
MEKK1 |
0.719 | -0.167 | 1 | 0.124 |
CHK1 |
0.719 | -0.073 | -3 | 0.849 |
DAPK3 |
0.719 | 0.044 | -3 | 0.861 |
MRCKB |
0.718 | 0.074 | -3 | 0.827 |
NEK11 |
0.718 | -0.120 | 1 | 0.137 |
MAP3K15 |
0.718 | -0.078 | 1 | 0.129 |
IRAK4 |
0.718 | -0.148 | 1 | 0.091 |
HRI |
0.717 | -0.183 | -2 | 0.771 |
DAPK1 |
0.717 | 0.053 | -3 | 0.856 |
GCK |
0.717 | -0.067 | 1 | 0.115 |
MEKK6 |
0.717 | -0.083 | 1 | 0.125 |
TLK1 |
0.716 | -0.163 | -2 | 0.758 |
CK1A2 |
0.716 | -0.008 | -3 | 0.437 |
CHK2 |
0.716 | 0.076 | -3 | 0.768 |
TAO2 |
0.715 | -0.067 | 2 | 0.762 |
HASPIN |
0.715 | 0.013 | -1 | 0.506 |
CAMK1D |
0.715 | 0.038 | -3 | 0.783 |
ROCK2 |
0.715 | 0.055 | -3 | 0.855 |
PLK3 |
0.715 | -0.161 | 2 | 0.660 |
NEK5 |
0.715 | -0.192 | 1 | 0.104 |
CK2A2 |
0.714 | -0.054 | 1 | 0.070 |
HPK1 |
0.714 | -0.056 | 1 | 0.116 |
TNIK |
0.714 | -0.053 | 3 | 0.867 |
BRAF |
0.713 | -0.183 | -4 | 0.798 |
LKB1 |
0.712 | -0.086 | -3 | 0.782 |
NEK8 |
0.712 | -0.159 | 2 | 0.754 |
KHS1 |
0.712 | -0.042 | 1 | 0.114 |
GRK3 |
0.711 | -0.084 | -2 | 0.633 |
CAMK1A |
0.711 | 0.061 | -3 | 0.780 |
LRRK2 |
0.711 | -0.022 | 2 | 0.777 |
MINK |
0.711 | -0.117 | 1 | 0.097 |
MRCKA |
0.711 | 0.045 | -3 | 0.830 |
EEF2K |
0.711 | -0.083 | 3 | 0.833 |
HGK |
0.711 | -0.093 | 3 | 0.853 |
KHS2 |
0.710 | -0.025 | 1 | 0.122 |
PBK |
0.709 | -0.036 | 1 | 0.144 |
CK1G1 |
0.709 | -0.071 | -3 | 0.478 |
LOK |
0.709 | -0.075 | -2 | 0.692 |
TTBK1 |
0.709 | -0.173 | 2 | 0.582 |
DMPK1 |
0.708 | 0.088 | -3 | 0.836 |
CRIK |
0.707 | 0.089 | -3 | 0.830 |
MST2 |
0.706 | -0.155 | 1 | 0.103 |
CK2A1 |
0.706 | -0.061 | 1 | 0.063 |
NEK4 |
0.705 | -0.192 | 1 | 0.093 |
TAK1 |
0.704 | -0.153 | 1 | 0.095 |
CAMKK2 |
0.704 | -0.178 | -2 | 0.661 |
SLK |
0.704 | -0.075 | -2 | 0.650 |
VRK1 |
0.704 | -0.151 | 2 | 0.758 |
ROCK1 |
0.704 | 0.052 | -3 | 0.832 |
CAMKK1 |
0.703 | -0.234 | -2 | 0.652 |
YSK1 |
0.702 | -0.109 | 2 | 0.757 |
NEK1 |
0.701 | -0.181 | 1 | 0.089 |
PKG1 |
0.701 | 0.030 | -2 | 0.581 |
MST1 |
0.699 | -0.168 | 1 | 0.095 |
BIKE |
0.698 | -0.039 | 1 | 0.153 |
OSR1 |
0.696 | -0.080 | 2 | 0.741 |
STK33 |
0.696 | -0.144 | 2 | 0.555 |
AAK1 |
0.695 | -0.007 | 1 | 0.164 |
IRAK1 |
0.695 | -0.254 | -1 | 0.553 |
PLK2 |
0.693 | -0.102 | -3 | 0.724 |
ASK1 |
0.692 | -0.122 | 1 | 0.129 |
RIPK2 |
0.692 | -0.208 | 1 | 0.100 |
MEK2 |
0.691 | -0.225 | 2 | 0.735 |
MYO3B |
0.690 | -0.081 | 2 | 0.773 |
PDHK3_TYR |
0.690 | 0.134 | 4 | 0.821 |
ALPHAK3 |
0.689 | -0.079 | -1 | 0.638 |
TAO1 |
0.688 | -0.092 | 1 | 0.120 |
MYO3A |
0.688 | -0.096 | 1 | 0.109 |
NEK3 |
0.688 | -0.164 | 1 | 0.132 |
TTK |
0.687 | -0.109 | -2 | 0.750 |
YANK3 |
0.687 | -0.048 | 2 | 0.358 |
BMPR2_TYR |
0.684 | 0.118 | -1 | 0.775 |
PKMYT1_TYR |
0.684 | 0.125 | 3 | 0.837 |
LIMK2_TYR |
0.684 | 0.114 | -3 | 0.864 |
TESK1_TYR |
0.682 | 0.039 | 3 | 0.878 |
MAP2K4_TYR |
0.681 | 0.042 | -1 | 0.704 |
PDHK4_TYR |
0.681 | 0.061 | 2 | 0.768 |
MAP2K6_TYR |
0.680 | 0.055 | -1 | 0.725 |
CK1A |
0.680 | -0.034 | -3 | 0.343 |
PDHK1_TYR |
0.680 | 0.037 | -1 | 0.751 |
MAP2K7_TYR |
0.677 | -0.060 | 2 | 0.757 |
PINK1_TYR |
0.677 | -0.054 | 1 | 0.163 |
EPHA6 |
0.674 | -0.010 | -1 | 0.743 |
STLK3 |
0.673 | -0.184 | 1 | 0.097 |
RET |
0.672 | -0.108 | 1 | 0.140 |
MST1R |
0.671 | -0.068 | 3 | 0.796 |
LIMK1_TYR |
0.670 | -0.019 | 2 | 0.764 |
JAK2 |
0.670 | -0.098 | 1 | 0.155 |
CSF1R |
0.669 | -0.073 | 3 | 0.760 |
JAK3 |
0.668 | -0.062 | 1 | 0.139 |
LCK |
0.668 | -0.009 | -1 | 0.749 |
BLK |
0.668 | -0.006 | -1 | 0.752 |
ABL2 |
0.667 | -0.079 | -1 | 0.642 |
TYK2 |
0.667 | -0.182 | 1 | 0.128 |
NEK10_TYR |
0.667 | -0.087 | 1 | 0.121 |
EPHB4 |
0.667 | -0.078 | -1 | 0.677 |
TXK |
0.667 | -0.047 | 1 | 0.092 |
ROS1 |
0.665 | -0.121 | 3 | 0.746 |
JAK1 |
0.665 | -0.081 | 1 | 0.129 |
YES1 |
0.663 | -0.089 | -1 | 0.685 |
FYN |
0.663 | 0.007 | -1 | 0.758 |
ABL1 |
0.663 | -0.097 | -1 | 0.625 |
HCK |
0.663 | -0.075 | -1 | 0.725 |
FGFR2 |
0.662 | -0.041 | 3 | 0.767 |
TNNI3K_TYR |
0.662 | -0.060 | 1 | 0.164 |
DDR1 |
0.662 | -0.118 | 4 | 0.756 |
ITK |
0.661 | -0.094 | -1 | 0.663 |
TYRO3 |
0.660 | -0.178 | 3 | 0.779 |
FGR |
0.660 | -0.154 | 1 | 0.098 |
KDR |
0.660 | -0.060 | 3 | 0.723 |
INSRR |
0.658 | -0.113 | 3 | 0.716 |
MET |
0.657 | -0.062 | 3 | 0.763 |
EPHA4 |
0.657 | -0.065 | 2 | 0.662 |
KIT |
0.657 | -0.110 | 3 | 0.761 |
FGFR1 |
0.656 | -0.072 | 3 | 0.733 |
FLT3 |
0.656 | -0.147 | 3 | 0.773 |
TNK1 |
0.656 | -0.090 | 3 | 0.760 |
FER |
0.655 | -0.180 | 1 | 0.108 |
BMX |
0.655 | -0.082 | -1 | 0.606 |
TEK |
0.654 | -0.034 | 3 | 0.703 |
CK1G3 |
0.654 | -0.053 | -3 | 0.300 |
TNK2 |
0.654 | -0.126 | 3 | 0.713 |
FLT1 |
0.653 | -0.072 | -1 | 0.724 |
SYK |
0.653 | 0.012 | -1 | 0.749 |
PTK2 |
0.653 | 0.038 | -1 | 0.777 |
CK1G2 |
0.653 | -0.011 | -3 | 0.391 |
SRMS |
0.652 | -0.166 | 1 | 0.086 |
PDGFRB |
0.652 | -0.198 | 3 | 0.775 |
FGFR3 |
0.652 | -0.055 | 3 | 0.734 |
EPHB1 |
0.652 | -0.155 | 1 | 0.097 |
FRK |
0.651 | -0.098 | -1 | 0.725 |
EPHB2 |
0.651 | -0.125 | -1 | 0.670 |
WEE1_TYR |
0.651 | -0.091 | -1 | 0.568 |
YANK2 |
0.650 | -0.078 | 2 | 0.367 |
DDR2 |
0.650 | -0.034 | 3 | 0.688 |
EPHB3 |
0.650 | -0.145 | -1 | 0.663 |
EGFR |
0.650 | -0.085 | 1 | 0.099 |
MERTK |
0.648 | -0.165 | 3 | 0.761 |
PDGFRA |
0.648 | -0.203 | 3 | 0.779 |
SRC |
0.647 | -0.078 | -1 | 0.705 |
ERBB2 |
0.647 | -0.134 | 1 | 0.113 |
EPHA7 |
0.645 | -0.107 | 2 | 0.666 |
ALK |
0.644 | -0.163 | 3 | 0.685 |
FLT4 |
0.644 | -0.136 | 3 | 0.722 |
TEC |
0.644 | -0.161 | -1 | 0.568 |
AXL |
0.644 | -0.204 | 3 | 0.743 |
BTK |
0.643 | -0.209 | -1 | 0.599 |
LYN |
0.642 | -0.110 | 3 | 0.678 |
EPHA8 |
0.642 | -0.071 | -1 | 0.703 |
ZAP70 |
0.641 | -0.007 | -1 | 0.663 |
EPHA1 |
0.641 | -0.139 | 3 | 0.744 |
INSR |
0.641 | -0.159 | 3 | 0.693 |
PTK2B |
0.641 | -0.121 | -1 | 0.586 |
ERBB4 |
0.640 | -0.046 | 1 | 0.092 |
FGFR4 |
0.640 | -0.103 | -1 | 0.613 |
EPHA3 |
0.640 | -0.133 | 2 | 0.633 |
LTK |
0.640 | -0.182 | 3 | 0.713 |
MATK |
0.639 | -0.112 | -1 | 0.570 |
MUSK |
0.639 | -0.125 | 1 | 0.079 |
PTK6 |
0.639 | -0.220 | -1 | 0.538 |
NTRK3 |
0.638 | -0.168 | -1 | 0.591 |
NTRK1 |
0.638 | -0.228 | -1 | 0.631 |
CSK |
0.637 | -0.133 | 2 | 0.674 |
NTRK2 |
0.635 | -0.234 | 3 | 0.729 |
EPHA5 |
0.635 | -0.136 | 2 | 0.636 |
EPHA2 |
0.632 | -0.087 | -1 | 0.679 |
IGF1R |
0.628 | -0.135 | 3 | 0.633 |
FES |
0.611 | -0.159 | -1 | 0.557 |