Motif 756 (n=185)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JPF8 | HNRNPCL4 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| A0MZ66 | SHTN1 | S514 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NKT7 | RGPD3 | S1573 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MTJ3 | GNAT3 | S206 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| B2RXH8 | HNRNPCL2 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| H0YC42 | None | S134 | ochoa | Tumor protein D52 | None |
| O00311 | CDC7 | S512 | ochoa | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O00443 | PIK3C2A | S60 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O00444 | PLK4 | S22 | psp | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| O00515 | LAD1 | S201 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14715 | RGPD8 | S1572 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14777 | NDC80 | S75 | ochoa|psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O15061 | SYNM | S1241 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15226 | NKRF | S192 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O15355 | PPM1G | S517 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43670 | ZNF207 | S358 | ochoa | BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187, ECO:0000269|PubMed:26388440}. |
| O43683 | BUB1 | S419 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43791 | SPOP | S119 | psp | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed:36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed:37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed:37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed:38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed:38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity). {ECO:0000250|UniProtKB:Q6ZWS8, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:32109420, ECO:0000269|PubMed:37622993, ECO:0000269|PubMed:37796126, ECO:0000269|PubMed:38018242}. |
| O60244 | MED14 | S625 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60287 | URB1 | S54 | ochoa | Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) | None |
| O60812 | HNRNPCL1 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O60832 | DKC1 | S422 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O75179 | ANKRD17 | S1566 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75436 | VPS26A | S47 | ochoa | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}. |
| O76070 | SNCG | S54 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| O94868 | FCHSD2 | S190 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O95405 | ZFYVE9 | S44 | ochoa | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}. |
| P02686 | MBP | S285 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P04275 | VWF | S1866 | ochoa | von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| P04899 | GNAI2 | S207 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P06744 | GPI | T250 | ochoa | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
| P07910 | HNRNPC | S38 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P07954 | FH | S75 | psp | Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2) | Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). {ECO:0000269|PubMed:30761759, ECO:0000305}.; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. {ECO:0000250|UniProtKB:P10173}.; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645). {ECO:0000250|UniProtKB:P97807, ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}. |
| P08754 | GNAI3 | S206 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09429 | HMGB1 | S46 | psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P09874 | PARP1 | S75 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0DMR1 | HNRNPCL4 | S38 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P11488 | GNAT1 | S202 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}. |
| P13010 | XRCC5 | S255 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P14317 | HCLS1 | S112 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P14618 | PKM | S202 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P17252 | PRKCA | S226 | ochoa|psp | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P19087 | GNAT2 | S206 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| P21333 | FLNA | S377 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P24278 | ZBTB25 | S342 | ochoa | Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) | May be involved in transcriptional regulation. |
| P26373 | RPL13 | S139 | ochoa | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
| P27635 | RPL10 | S137 | ochoa | Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) | Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}. |
| P27708 | CAD | S1321 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P29401 | TKT | S276 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P29966 | MARCKS | S170 | ochoa|psp | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P30622 | CLIP1 | S20 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P31269 | HOXA9 | S205 | psp | Homeobox protein Hox-A9 (Homeobox protein Hox-1G) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity). {ECO:0000250|UniProtKB:P09631, ECO:0000269|PubMed:22269951}. |
| P31483 | TIA1 | S86 | ochoa | Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1) | RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:11106748, PubMed:12486009, PubMed:17488725, PubMed:8576255). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:11106748, PubMed:8576255). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (By similarity). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:11106748). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (PubMed:11106748, PubMed:12486009, PubMed:17488725). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (By similarity). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (PubMed:17580305). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (PubMed:17580305). Binds specifically to a polypyrimidine-rich controlling element (PCE) located between the weak 5' splice site and the intronic splicing silencer of CFTR mRNA to promote exon 9 inclusion, thereby antagonizing PTB1 and its role in exon skipping of CFTR exon 9 (PubMed:14966131). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (By similarity). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (PubMed:10613902). Formation and recruitment to SGs is regulated by Zn(2+) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1934064). {ECO:0000250|UniProtKB:P52912, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:11106748, ECO:0000269|PubMed:12486009, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:17580305, ECO:0000269|PubMed:1934064, ECO:0000269|PubMed:8576255}.; FUNCTION: [Isoform Short]: Displays enhanced splicing regulatory activity compared with TIA isoform Long. {ECO:0000269|PubMed:17488725}. |
| P34932 | HSPA4 | S647 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P35611 | ADD1 | S483 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P43490 | NAMPT | S472 | ochoa | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| P46013 | MKI67 | S1142 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1264 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1506 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1628 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1750 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1994 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2355 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2599 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2719 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46060 | RANGAP1 | S24 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P46100 | ATRX | S313 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S706 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S601 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48730 | CSNK1D | S53 | psp | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49792 | RANBP2 | S2548 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51587 | BRCA2 | S239 | ochoa|psp | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52272 | HNRNPM | S136 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52292 | KPNA2 | S305 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P54132 | BLM | S72 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P60900 | PSMA6 | S64 | ochoa | Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P62714 | PPP2CB | S43 | ochoa | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
| P63096 | GNAI1 | S206 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P67775 | PPP2CA | S43 | ochoa | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
| P83731 | RPL24 | S86 | ochoa | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q00341 | HDLBP | S581 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q01085 | TIAL1 | S88 | ochoa | Nucleolysin TIAR (TIA-1-related protein) | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:10613902, PubMed:1326761, PubMed:17488725, PubMed:8576255). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:1326761, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:8576255}. |
| Q01105 | SET | S183 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01804 | OTUD4 | S1049 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q02952 | AKAP12 | S1119 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05655 | PRKCD | S359 | psp | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q08211 | DHX9 | S1033 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12893 | TMEM115 | S267 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
| Q13151 | HNRNPA0 | S135 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13206 | DDX10 | S52 | ochoa | Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) | Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level (PubMed:32519665). Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression (PubMed:36779599). {ECO:0000269|PubMed:32519665, ECO:0000269|PubMed:36779599}. |
| Q13315 | ATM | S1981 | ochoa|psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13418 | ILK | S186 | ochoa | Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) | Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:16517730, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:18283114, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:30367047, ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:9736715}. |
| Q13428 | TCOF1 | S233 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14247 | CTTN | S345 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14669 | TRIP12 | S109 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14669 | TRIP12 | S1057 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14687 | GSE1 | S1007 | ochoa | Genetic suppressor element 1 | None |
| Q14865 | ARID5B | S469 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
| Q14966 | ZNF638 | S636 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15022 | SUZ12 | S384 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15147 | PLCB4 | S891 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) | Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927). {ECO:0000250|UniProtKB:Q07722, ECO:0000269|PubMed:35284927}. |
| Q15424 | SAFB | S587 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15700 | DLG2 | S627 | ochoa | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}. |
| Q16649 | NFIL3 | S20 | ochoa | Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}. |
| Q16659 | MAPK6 | S511 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q16666 | IFI16 | S132 | psp | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q2KHR3 | QSER1 | S1257 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q5JTH9 | RRP12 | S118 | ochoa | RRP12-like protein | None |
| Q5T1R4 | HIVEP3 | S804 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T3I0 | GPATCH4 | S117 | ochoa | G patch domain-containing protein 4 | None |
| Q5T7B8 | KIF24 | S603 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5UIP0 | RIF1 | S1760 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q659A1 | ICE2 | S326 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q6KC79 | NIPBL | S1196 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6UB98 | ANKRD12 | S1166 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6VMQ6 | ATF7IP | S334 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZNB6 | NFXL1 | S331 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q6ZU52 | KIAA0408 | S248 | ochoa | Uncharacterized protein KIAA0408 | None |
| Q7L2Z9 | CENPQ | S50 | ochoa|psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q7Z6E9 | RBBP6 | S1353 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q8IVF2 | AHNAK2 | S4641 | ochoa | Protein AHNAK2 | None |
| Q8IZH2 | XRN1 | S1625 | ochoa | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. |
| Q8IZT6 | ASPM | S570 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N0T1 | RBIS | S19 | ochoa | Ribosomal biogenesis factor | Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. {ECO:0000269|PubMed:26711351}. |
| Q8N264 | ARHGAP24 | S437 | psp | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Q8NC26 | ZNF114 | S291 | ochoa | Zinc finger protein 114 | May be involved in transcriptional regulation. |
| Q8ND24 | RNF214 | S54 | ochoa | RING finger protein 214 | None |
| Q8NEZ4 | KMT2C | S2811 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NG31 | KNL1 | S405 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NG31 | KNL1 | S682 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8WU79 | SMAP2 | S176 | ochoa | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}. |
| Q8WVK2 | SNRNP27 | S132 | ochoa | U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3) | May play a role in mRNA splicing. |
| Q8WWI1 | LMO7 | S1449 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WY91 | THAP4 | S239 | ochoa | Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) | Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}. |
| Q92625 | ANKS1A | S331 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92800 | EZH1 | S490 | ochoa | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}. |
| Q92834 | RPGR | S961 | ochoa | X-linked retinitis pigmentosa GTPase regulator | Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:20631154). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (PubMed:20631154). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (By similarity). Involved in photoreceptor integrity (By similarity). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (PubMed:21933838). May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). {ECO:0000250|UniProtKB:Q9R0X5, ECO:0000269|PubMed:20631154, ECO:0000269|PubMed:21933838}. |
| Q92974 | ARHGEF2 | S109 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q96AQ6 | PBXIP1 | S550 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96HC4 | PDLIM5 | S85 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JB1 | DNAH8 | S3116 | ochoa | Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8) | Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. {ECO:0000269|PubMed:32619401}. |
| Q96QD5 | DEPDC7 | S486 | ochoa | DEP domain-containing protein 7 (Protein TR2/D15) | None |
| Q96SU4 | OSBPL9 | S611 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q99728 | BARD1 | S148 | psp | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
| Q9BPZ7 | MAPKAP1 | S185 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BU68 | PRR15L | S73 | ochoa | Proline-rich protein 15-like protein (Protein ATAD4) | None |
| Q9H4A3 | WNK1 | S599 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H5J8 | TAF1D | S138 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9HB90 | RRAGC | S95 | ochoa | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
| Q9NQL2 | RRAGD | S96 | ochoa | Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:34607910). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagD/RRAGD is in its active form when GDP-bound RagD/RRAGD forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagD/RRAGD heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279). In its active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagD/RRAGD mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34607910}. |
| Q9NW13 | RBM28 | S122 | ochoa|psp | RNA-binding protein 28 (RNA-binding motif protein 28) | Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
| Q9UEE9 | CFDP1 | S216 | ochoa | Craniofacial development protein 1 (Bucentaur) | May play a role during embryogenesis. {ECO:0000250}. |
| Q9UGP8 | SEC63 | S544 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UJU6 | DBNL | S160 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q9UKV3 | ACIN1 | S870 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULJ3 | ZBTB21 | S202 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UNE0 | EDAR | S273 | ochoa | Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) | Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
| Q9Y2R2 | PTPN22 | S35 | psp | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}. |
| Q9Y4W2 | LAS1L | S235 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y5K6 | CD2AP | S553 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y6M5 | SLC30A1 | S473 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6Y8 | SEC23IP | S742 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| Q02878 | RPL6 | Y216 | Sugiyama | Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.; FUNCTION: (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). {ECO:0000269|PubMed:8457378}. |
| P31327 | CPS1 | S569 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31948 | STIP1 | S28 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| Q15084 | PDIA6 | S169 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| O15075 | DCLK1 | S438 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| A6NMY6 | ANXA2P2 | S243 | Sugiyama | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| P07355 | ANXA2 | S243 | Sugiyama | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| O76021 | RSL1D1 | S314 | Sugiyama | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| P05783 | KRT18 | S127 | Sugiyama | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P12268 | IMPDH2 | S432 | Sugiyama | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| Q9BTE6 | AARSD1 | S242 | Sugiyama | Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1) | Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). {ECO:0000250}. |
| O75663 | TIPRL | S124 | Sugiyama | TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP) | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681, ECO:0000269|PubMed:26717153}. |
| Q6NZY4 | ZCCHC8 | S605 | Sugiyama | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q00796 | SORD | S73 | Sugiyama | Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:25105142, PubMed:29966615). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:3365415, ECO:0000303|PubMed:25105142, ECO:0000303|PubMed:29966615, ECO:0000305|PubMed:12962626}. |
| P61201 | COPS2 | S221 | Sugiyama | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| P29475 | NOS1 | S746 | iPTMNet | Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1) | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. {ECO:0000269|PubMed:35772285}. |
| Q13200 | PSMD2 | Y103 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
| P27144 | AK4 | S195 | Sugiyama | Adenylate kinase 4, mitochondrial (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4) | Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP (PubMed:19766732). Phosphorylates only AMP when using GTP as phosphate donor (PubMed:19766732). In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor (PubMed:19766732, PubMed:23416111). Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors (PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435). {ECO:0000269|PubMed:19073142, ECO:0000269|PubMed:19130895, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:23474458, ECO:0000269|PubMed:24767988, ECO:0000269|PubMed:26980435}. |
| P32969 | RPL9 | S137 | Sugiyama | Large ribosomal subunit protein uL6 (60S ribosomal protein L9) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q5S007 | LRRK2 | S1508 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| O14980 | XPO1 | S690 | Sugiyama | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| P46013 | MKI67 | S2116 | Sugiyama | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.079464e-08 | 7.512 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.079464e-08 | 7.512 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.361628e-08 | 7.133 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.603436e-07 | 6.795 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.728442e-07 | 6.428 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.847987e-07 | 6.314 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.073322e-06 | 5.969 |
| R-HSA-111885 | Opioid Signalling | 1.888039e-06 | 5.724 |
| R-HSA-68877 | Mitotic Prometaphase | 2.568274e-06 | 5.590 |
| R-HSA-68886 | M Phase | 2.715181e-06 | 5.566 |
| R-HSA-1640170 | Cell Cycle | 3.429913e-06 | 5.465 |
| R-HSA-112040 | G-protein mediated events | 4.763335e-06 | 5.322 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.507304e-06 | 5.125 |
| R-HSA-68882 | Mitotic Anaphase | 8.040667e-06 | 5.095 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.405991e-06 | 5.075 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.640325e-05 | 4.785 |
| R-HSA-8953854 | Metabolism of RNA | 1.802870e-05 | 4.744 |
| R-HSA-168255 | Influenza Infection | 3.745889e-05 | 4.426 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.559033e-05 | 4.255 |
| R-HSA-75153 | Apoptotic execution phase | 6.017945e-05 | 4.221 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.523026e-05 | 4.186 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 9.646726e-05 | 4.016 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.165771e-04 | 3.933 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.254331e-04 | 3.902 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.380798e-04 | 3.860 |
| R-HSA-418597 | G alpha (z) signalling events | 1.386731e-04 | 3.858 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.606473e-04 | 3.794 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.606473e-04 | 3.794 |
| R-HSA-156902 | Peptide chain elongation | 2.114595e-04 | 3.675 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.342373e-04 | 3.630 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.731900e-04 | 3.564 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.731900e-04 | 3.564 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.731900e-04 | 3.564 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.731900e-04 | 3.564 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.538690e-04 | 3.595 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.694359e-04 | 3.570 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.715409e-04 | 3.566 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.857616e-04 | 3.544 |
| R-HSA-72312 | rRNA processing | 3.023012e-04 | 3.520 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.081417e-04 | 3.511 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 3.165872e-04 | 3.500 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.395644e-04 | 3.469 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.592009e-04 | 3.445 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.592009e-04 | 3.445 |
| R-HSA-9711097 | Cellular response to starvation | 3.487336e-04 | 3.458 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.449635e-04 | 3.352 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.579359e-04 | 3.339 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.969731e-04 | 3.304 |
| R-HSA-192823 | Viral mRNA Translation | 5.512511e-04 | 3.259 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.801039e-04 | 3.236 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 6.103035e-04 | 3.214 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.077468e-04 | 3.150 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.428936e-04 | 3.129 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.428936e-04 | 3.129 |
| R-HSA-2262752 | Cellular responses to stress | 9.174184e-04 | 3.037 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 9.549891e-04 | 3.020 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.175944e-03 | 2.930 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.175944e-03 | 2.930 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.290023e-03 | 2.889 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.298941e-03 | 2.886 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.417872e-03 | 2.848 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.554302e-03 | 2.808 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.699611e-03 | 2.770 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.699611e-03 | 2.770 |
| R-HSA-392518 | Signal amplification | 1.699611e-03 | 2.770 |
| R-HSA-109581 | Apoptosis | 1.786236e-03 | 2.748 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.854093e-03 | 2.732 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.018041e-03 | 2.695 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.375497e-03 | 2.624 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.569582e-03 | 2.590 |
| R-HSA-70171 | Glycolysis | 2.572291e-03 | 2.590 |
| R-HSA-163685 | Integration of energy metabolism | 2.917296e-03 | 2.535 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 3.414355e-03 | 2.467 |
| R-HSA-991365 | Activation of GABAB receptors | 3.454886e-03 | 2.462 |
| R-HSA-977444 | GABA B receptor activation | 3.454886e-03 | 2.462 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.240979e-03 | 2.373 |
| R-HSA-9675135 | Diseases of DNA repair | 4.527697e-03 | 2.344 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.139709e-03 | 2.289 |
| R-HSA-6803529 | FGFR2 alternative splicing | 5.061120e-03 | 2.296 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.720876e-03 | 2.326 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.173241e-03 | 2.286 |
| R-HSA-9634597 | GPER1 signaling | 5.139709e-03 | 2.289 |
| R-HSA-70326 | Glucose metabolism | 5.703515e-03 | 2.244 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.930133e-03 | 2.227 |
| R-HSA-418594 | G alpha (i) signalling events | 6.617052e-03 | 2.179 |
| R-HSA-5357801 | Programmed Cell Death | 6.739612e-03 | 2.171 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 6.803528e-03 | 2.167 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.350347e-03 | 2.134 |
| R-HSA-69481 | G2/M Checkpoints | 8.302025e-03 | 2.081 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.642613e-03 | 2.016 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 9.642613e-03 | 2.016 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.642613e-03 | 2.016 |
| R-HSA-977443 | GABA receptor activation | 9.992335e-03 | 2.000 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.291814e-02 | 1.889 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.291814e-02 | 1.889 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.291814e-02 | 1.889 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.471253e-02 | 1.832 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.660769e-02 | 1.780 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.660769e-02 | 1.780 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.660769e-02 | 1.780 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.660769e-02 | 1.780 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.660769e-02 | 1.780 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.122724e-02 | 1.950 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.385687e-02 | 1.858 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.241215e-02 | 1.906 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.471253e-02 | 1.832 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.576645e-02 | 1.802 |
| R-HSA-4839744 | Signaling by APC mutants | 1.291814e-02 | 1.889 |
| R-HSA-202670 | ERKs are inactivated | 1.471253e-02 | 1.832 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.471253e-02 | 1.832 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.471253e-02 | 1.832 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.417024e-02 | 1.849 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.471253e-02 | 1.832 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.471253e-02 | 1.832 |
| R-HSA-112043 | PLC beta mediated events | 1.049524e-02 | 1.979 |
| R-HSA-69275 | G2/M Transition | 1.343907e-02 | 1.872 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.410051e-02 | 1.851 |
| R-HSA-111933 | Calmodulin induced events | 1.606248e-02 | 1.794 |
| R-HSA-111997 | CaM pathway | 1.606248e-02 | 1.794 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.576645e-02 | 1.802 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.241215e-02 | 1.906 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.251365e-02 | 1.903 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.417024e-02 | 1.849 |
| R-HSA-162582 | Signal Transduction | 1.416822e-02 | 1.849 |
| R-HSA-190236 | Signaling by FGFR | 1.124411e-02 | 1.949 |
| R-HSA-8939211 | ESR-mediated signaling | 1.413248e-02 | 1.850 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.808990e-02 | 1.743 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.860095e-02 | 1.730 |
| R-HSA-69541 | Stabilization of p53 | 1.915452e-02 | 1.718 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.915452e-02 | 1.718 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.405086e-02 | 1.619 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.405086e-02 | 1.619 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.405086e-02 | 1.619 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.405086e-02 | 1.619 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.405086e-02 | 1.619 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.405086e-02 | 1.619 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.405086e-02 | 1.619 |
| R-HSA-9672393 | Defective F8 binding to von Willebrand factor | 2.405086e-02 | 1.619 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.405086e-02 | 1.619 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.405086e-02 | 1.619 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.287128e-02 | 1.641 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.138588e-02 | 1.670 |
| R-HSA-5693538 | Homology Directed Repair | 2.350423e-02 | 1.629 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.287128e-02 | 1.641 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.025317e-02 | 1.694 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.287128e-02 | 1.641 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.138588e-02 | 1.670 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.065336e-02 | 1.685 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.287128e-02 | 1.641 |
| R-HSA-111996 | Ca-dependent events | 2.375355e-02 | 1.624 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.263758e-02 | 1.645 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.953928e-02 | 1.709 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.443593e-02 | 1.612 |
| R-HSA-68875 | Mitotic Prophase | 2.486158e-02 | 1.604 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.514326e-02 | 1.600 |
| R-HSA-73886 | Chromosome Maintenance | 2.555876e-02 | 1.592 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.750311e-02 | 1.561 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.756049e-02 | 1.560 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.772513e-02 | 1.557 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.858114e-02 | 1.544 |
| R-HSA-69206 | G1/S Transition | 2.923233e-02 | 1.534 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.966086e-02 | 1.528 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 3.585959e-02 | 1.445 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.762647e-02 | 1.425 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.919808e-02 | 1.407 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.777329e-02 | 1.423 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.762647e-02 | 1.425 |
| R-HSA-912446 | Meiotic recombination | 3.608799e-02 | 1.443 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.311100e-02 | 1.480 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.311100e-02 | 1.480 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.692206e-02 | 1.433 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.508582e-02 | 1.455 |
| R-HSA-195721 | Signaling by WNT | 4.212664e-02 | 1.375 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.167277e-02 | 1.499 |
| R-HSA-198753 | ERK/MAPK targets | 4.053690e-02 | 1.392 |
| R-HSA-9909396 | Circadian clock | 3.577413e-02 | 1.446 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.023638e-02 | 1.395 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.247676e-02 | 1.488 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.508582e-02 | 1.455 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.680957e-02 | 1.434 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.762647e-02 | 1.425 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.586538e-02 | 1.445 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.244001e-02 | 1.372 |
| R-HSA-6807070 | PTEN Regulation | 4.315319e-02 | 1.365 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.410997e-02 | 1.355 |
| R-HSA-73894 | DNA Repair | 4.430388e-02 | 1.354 |
| R-HSA-422356 | Regulation of insulin secretion | 4.522030e-02 | 1.345 |
| R-HSA-166208 | mTORC1-mediated signalling | 4.628376e-02 | 1.335 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.628376e-02 | 1.335 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 4.752615e-02 | 1.323 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 4.752615e-02 | 1.323 |
| R-HSA-9672391 | Defective F8 cleavage by thrombin | 4.752615e-02 | 1.323 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 4.752615e-02 | 1.323 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.111172e-02 | 1.291 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.138455e-02 | 1.289 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.294153e-02 | 1.276 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.480262e-02 | 1.261 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 5.542112e-02 | 1.256 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.669473e-02 | 1.246 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.696525e-02 | 1.244 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 5.859655e-02 | 1.232 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 6.183348e-02 | 1.209 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 7.043959e-02 | 1.152 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 8.168980e-02 | 1.088 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 8.168980e-02 | 1.088 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 8.168980e-02 | 1.088 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 9.280454e-02 | 1.032 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 8.971834e-02 | 1.047 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.456820e-02 | 1.190 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.918551e-02 | 1.160 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 8.971834e-02 | 1.047 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.605603e-02 | 1.065 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 8.168980e-02 | 1.088 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 9.280454e-02 | 1.032 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 6.512998e-02 | 1.186 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 6.848414e-02 | 1.164 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 7.535804e-02 | 1.123 |
| R-HSA-4791275 | Signaling by WNT in cancer | 7.887418e-02 | 1.103 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 8.971834e-02 | 1.047 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 8.244075e-02 | 1.084 |
| R-HSA-6798695 | Neutrophil degranulation | 6.897312e-02 | 1.161 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 7.291620e-02 | 1.137 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 7.291620e-02 | 1.137 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 7.887418e-02 | 1.103 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 7.189410e-02 | 1.143 |
| R-HSA-5689603 | UCH proteinases | 8.398914e-02 | 1.076 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.947711e-02 | 1.100 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.548231e-02 | 1.068 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 8.605603e-02 | 1.065 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 8.971834e-02 | 1.047 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.860857e-02 | 1.053 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 7.189410e-02 | 1.143 |
| R-HSA-5673000 | RAF activation | 8.971834e-02 | 1.047 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 8.168980e-02 | 1.088 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 8.971834e-02 | 1.047 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.291620e-02 | 1.137 |
| R-HSA-162906 | HIV Infection | 8.300144e-02 | 1.081 |
| R-HSA-180024 | DARPP-32 events | 6.848414e-02 | 1.164 |
| R-HSA-4086400 | PCP/CE pathway | 8.860857e-02 | 1.053 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 6.848414e-02 | 1.164 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.405700e-02 | 1.075 |
| R-HSA-9675108 | Nervous system development | 6.643138e-02 | 1.178 |
| R-HSA-422475 | Axon guidance | 8.707587e-02 | 1.060 |
| R-HSA-9833482 | PKR-mediated signaling | 9.333270e-02 | 1.030 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 9.342603e-02 | 1.030 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 9.342603e-02 | 1.030 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 9.342603e-02 | 1.030 |
| R-HSA-169911 | Regulation of Apoptosis | 9.342603e-02 | 1.030 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 9.573318e-02 | 1.019 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9.717748e-02 | 1.012 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 9.717748e-02 | 1.012 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.797270e-02 | 1.009 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.037854e-01 | 0.984 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.146341e-01 | 0.941 |
| R-HSA-164843 | 2-LTR circle formation | 1.464023e-01 | 0.834 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.245333e-01 | 0.905 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.367644e-01 | 0.864 |
| R-HSA-774815 | Nucleosome assembly | 1.367644e-01 | 0.864 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.367644e-01 | 0.864 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.202016e-01 | 0.920 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.210624e-01 | 0.917 |
| R-HSA-9664873 | Pexophagy | 1.464023e-01 | 0.834 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.770363e-01 | 0.752 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.037854e-01 | 0.984 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.146341e-01 | 0.941 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.705209e-01 | 0.768 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.595435e-01 | 0.797 |
| R-HSA-9907900 | Proteasome assembly | 1.326577e-01 | 0.877 |
| R-HSA-72172 | mRNA Splicing | 1.397026e-01 | 0.855 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.646876e-01 | 0.783 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.146341e-01 | 0.941 |
| R-HSA-5652227 | Fructose biosynthesis | 1.253521e-01 | 0.902 |
| R-HSA-192814 | vRNA Synthesis | 1.567376e-01 | 0.805 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.669485e-01 | 0.777 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.770363e-01 | 0.752 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.870025e-01 | 0.728 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.408990e-01 | 0.851 |
| R-HSA-165159 | MTOR signalling | 1.245333e-01 | 0.905 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.253521e-01 | 0.902 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.600602e-01 | 0.796 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.408990e-01 | 0.851 |
| R-HSA-157579 | Telomere Maintenance | 1.457111e-01 | 0.837 |
| R-HSA-2514856 | The phototransduction cascade | 1.619481e-01 | 0.791 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.464023e-01 | 0.834 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.086786e-01 | 0.964 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.205183e-01 | 0.919 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.205183e-01 | 0.919 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.450604e-01 | 0.838 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.705209e-01 | 0.768 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 1.408990e-01 | 0.851 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.705209e-01 | 0.768 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.878804e-01 | 0.726 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.037854e-01 | 0.984 |
| R-HSA-4641258 | Degradation of DVL | 1.009711e-01 | 0.996 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.086786e-01 | 0.964 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.081057e-01 | 0.966 |
| R-HSA-72766 | Translation | 1.007111e-01 | 0.997 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.055830e-01 | 0.976 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.184265e-01 | 0.927 |
| R-HSA-9662001 | Defective factor VIII causes hemophilia A | 1.037854e-01 | 0.984 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.669485e-01 | 0.777 |
| R-HSA-4641257 | Degradation of AXIN | 1.009711e-01 | 0.996 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.009711e-01 | 0.996 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.662247e-01 | 0.779 |
| R-HSA-1500620 | Meiosis | 1.055830e-01 | 0.976 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.748357e-01 | 0.757 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.659171e-01 | 0.780 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.838524e-01 | 0.736 |
| R-HSA-162592 | Integration of provirus | 1.669485e-01 | 0.777 |
| R-HSA-388396 | GPCR downstream signalling | 1.735618e-01 | 0.761 |
| R-HSA-8956320 | Nucleotide biosynthesis | 1.705209e-01 | 0.768 |
| R-HSA-8964011 | HDL clearance | 1.037854e-01 | 0.984 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.253521e-01 | 0.902 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.205183e-01 | 0.919 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.205183e-01 | 0.919 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.576922e-01 | 0.802 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.662247e-01 | 0.779 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.808273e-01 | 0.743 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.306716e-01 | 0.884 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.769615e-01 | 0.752 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.285802e-01 | 0.891 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.125895e-01 | 0.949 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.165366e-01 | 0.934 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.367644e-01 | 0.864 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.285802e-01 | 0.891 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.895974e-01 | 0.722 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.180054e-01 | 0.928 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.464023e-01 | 0.834 |
| R-HSA-112316 | Neuronal System | 1.446105e-01 | 0.840 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.835165e-01 | 0.736 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.274469e-01 | 0.895 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.086786e-01 | 0.964 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.285802e-01 | 0.891 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.326577e-01 | 0.877 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.367644e-01 | 0.864 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.367644e-01 | 0.864 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.326577e-01 | 0.877 |
| R-HSA-69236 | G1 Phase | 1.326577e-01 | 0.877 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.106517e-01 | 0.956 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.006092e-01 | 0.997 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.020984e-01 | 0.991 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.125895e-01 | 0.949 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.165366e-01 | 0.934 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.367644e-01 | 0.864 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.428945e-01 | 0.845 |
| R-HSA-9766229 | Degradation of CDH1 | 1.534582e-01 | 0.814 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.619481e-01 | 0.791 |
| R-HSA-74160 | Gene expression (Transcription) | 1.753801e-01 | 0.756 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.367644e-01 | 0.864 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.367644e-01 | 0.864 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.457111e-01 | 0.837 |
| R-HSA-162587 | HIV Life Cycle | 1.661564e-01 | 0.779 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.619481e-01 | 0.791 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.210389e-01 | 0.917 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.705209e-01 | 0.768 |
| R-HSA-202403 | TCR signaling | 1.868909e-01 | 0.728 |
| R-HSA-8983711 | OAS antiviral response | 1.770363e-01 | 0.752 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.619481e-01 | 0.791 |
| R-HSA-418346 | Platelet homeostasis | 1.748192e-01 | 0.757 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.878804e-01 | 0.726 |
| R-HSA-1500931 | Cell-Cell communication | 1.180249e-01 | 0.928 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.205183e-01 | 0.919 |
| R-HSA-446728 | Cell junction organization | 1.578447e-01 | 0.802 |
| R-HSA-212436 | Generic Transcription Pathway | 1.477224e-01 | 0.831 |
| R-HSA-9824446 | Viral Infection Pathways | 1.076589e-01 | 0.968 |
| R-HSA-9824272 | Somitogenesis | 1.367644e-01 | 0.864 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.567376e-01 | 0.805 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.571561e-01 | 0.804 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.808273e-01 | 0.743 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.485459e-01 | 0.828 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.485459e-01 | 0.828 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.485459e-01 | 0.828 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.838524e-01 | 0.736 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.868909e-01 | 0.728 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.868909e-01 | 0.728 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.718368e-01 | 0.765 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.960841e-01 | 0.708 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.241695e-01 | 0.906 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.966505e-01 | 0.706 |
| R-HSA-180786 | Extension of Telomeres | 1.966505e-01 | 0.706 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.968487e-01 | 0.706 |
| R-HSA-435354 | Zinc transporters | 1.968487e-01 | 0.706 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.979258e-01 | 0.703 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.990982e-01 | 0.701 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.991731e-01 | 0.701 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.010547e-01 | 0.697 |
| R-HSA-351202 | Metabolism of polyamines | 2.010547e-01 | 0.697 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.010547e-01 | 0.697 |
| R-HSA-418555 | G alpha (s) signalling events | 2.023842e-01 | 0.694 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.053860e-01 | 0.687 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.053860e-01 | 0.687 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.054704e-01 | 0.687 |
| R-HSA-450294 | MAP kinase activation | 2.054704e-01 | 0.687 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.065762e-01 | 0.685 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.065762e-01 | 0.685 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.065762e-01 | 0.685 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.073851e-01 | 0.683 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.073851e-01 | 0.683 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 2.073851e-01 | 0.683 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 2.073851e-01 | 0.683 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.085092e-01 | 0.681 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.098967e-01 | 0.678 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.143326e-01 | 0.669 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.143326e-01 | 0.669 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.161865e-01 | 0.665 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 2.161865e-01 | 0.665 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.161865e-01 | 0.665 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.161865e-01 | 0.665 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.211056e-01 | 0.655 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.211056e-01 | 0.655 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.211056e-01 | 0.655 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.232301e-01 | 0.651 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.232301e-01 | 0.651 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.238365e-01 | 0.650 |
| R-HSA-913531 | Interferon Signaling | 2.238365e-01 | 0.650 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.256810e-01 | 0.647 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.256810e-01 | 0.647 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.256810e-01 | 0.647 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.256810e-01 | 0.647 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.256810e-01 | 0.647 |
| R-HSA-5661270 | Formation of xylulose-5-phosphate | 2.256810e-01 | 0.647 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 2.256810e-01 | 0.647 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.257154e-01 | 0.646 |
| R-HSA-3371556 | Cellular response to heat stress | 2.274613e-01 | 0.643 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.276899e-01 | 0.643 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.276899e-01 | 0.643 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.306524e-01 | 0.637 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.306524e-01 | 0.637 |
| R-HSA-4839726 | Chromatin organization | 2.315981e-01 | 0.635 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.350611e-01 | 0.629 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.350611e-01 | 0.629 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.411040e-01 | 0.618 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.413054e-01 | 0.617 |
| R-HSA-194138 | Signaling by VEGF | 2.434970e-01 | 0.614 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.443281e-01 | 0.612 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.443281e-01 | 0.612 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.443281e-01 | 0.612 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.443281e-01 | 0.612 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.455843e-01 | 0.610 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.455843e-01 | 0.610 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.455843e-01 | 0.610 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.455843e-01 | 0.610 |
| R-HSA-448424 | Interleukin-17 signaling | 2.455843e-01 | 0.610 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 2.531818e-01 | 0.597 |
| R-HSA-500753 | Pyrimidine biosynthesis | 2.534834e-01 | 0.596 |
| R-HSA-9671793 | Diseases of hemostasis | 2.534834e-01 | 0.596 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.534834e-01 | 0.596 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.545538e-01 | 0.594 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.545538e-01 | 0.594 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.545538e-01 | 0.594 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.590415e-01 | 0.587 |
| R-HSA-4086398 | Ca2+ pathway | 2.590415e-01 | 0.587 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.590415e-01 | 0.587 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 2.625283e-01 | 0.581 |
| R-HSA-373753 | Nephrin family interactions | 2.625283e-01 | 0.581 |
| R-HSA-1474165 | Reproduction | 2.629703e-01 | 0.580 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.635303e-01 | 0.579 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.671136e-01 | 0.573 |
| R-HSA-380287 | Centrosome maturation | 2.680195e-01 | 0.572 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 2.680195e-01 | 0.572 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.680195e-01 | 0.572 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.680195e-01 | 0.572 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.714642e-01 | 0.566 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.714642e-01 | 0.566 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 2.714642e-01 | 0.566 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.714642e-01 | 0.566 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.725084e-01 | 0.565 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.727817e-01 | 0.564 |
| R-HSA-372790 | Signaling by GPCR | 2.735825e-01 | 0.563 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.747286e-01 | 0.561 |
| R-HSA-109582 | Hemostasis | 2.770220e-01 | 0.557 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.802924e-01 | 0.552 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.802924e-01 | 0.552 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.802924e-01 | 0.552 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.802924e-01 | 0.552 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.802924e-01 | 0.552 |
| R-HSA-5619084 | ABC transporter disorders | 2.814828e-01 | 0.551 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.859231e-01 | 0.544 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 2.890141e-01 | 0.539 |
| R-HSA-5652084 | Fructose metabolism | 2.890141e-01 | 0.539 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.892172e-01 | 0.539 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.904486e-01 | 0.537 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.925142e-01 | 0.534 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.976307e-01 | 0.526 |
| R-HSA-3000170 | Syndecan interactions | 2.976307e-01 | 0.526 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.976307e-01 | 0.526 |
| R-HSA-1632852 | Macroautophagy | 3.024199e-01 | 0.519 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.061434e-01 | 0.514 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.061434e-01 | 0.514 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 3.061434e-01 | 0.514 |
| R-HSA-9865881 | Complex III assembly | 3.061434e-01 | 0.514 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.083353e-01 | 0.511 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.083353e-01 | 0.511 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.083353e-01 | 0.511 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.090333e-01 | 0.510 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.123421e-01 | 0.505 |
| R-HSA-9620244 | Long-term potentiation | 3.145534e-01 | 0.502 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.145534e-01 | 0.502 |
| R-HSA-3214842 | HDMs demethylate histones | 3.145534e-01 | 0.502 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.228620e-01 | 0.491 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.228620e-01 | 0.491 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.228620e-01 | 0.491 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.228620e-01 | 0.491 |
| R-HSA-70635 | Urea cycle | 3.228620e-01 | 0.491 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.255852e-01 | 0.487 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.261332e-01 | 0.487 |
| R-HSA-70268 | Pyruvate metabolism | 3.261332e-01 | 0.487 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.261332e-01 | 0.487 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.288967e-01 | 0.483 |
| R-HSA-418990 | Adherens junctions interactions | 3.294958e-01 | 0.482 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.305651e-01 | 0.481 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.310704e-01 | 0.480 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.310704e-01 | 0.480 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.310704e-01 | 0.480 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.310704e-01 | 0.480 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.310704e-01 | 0.480 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.310704e-01 | 0.480 |
| R-HSA-8951664 | Neddylation | 3.377259e-01 | 0.471 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.391798e-01 | 0.470 |
| R-HSA-5620971 | Pyroptosis | 3.391798e-01 | 0.470 |
| R-HSA-202424 | Downstream TCR signaling | 3.394042e-01 | 0.469 |
| R-HSA-5663205 | Infectious disease | 3.405796e-01 | 0.468 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.421382e-01 | 0.466 |
| R-HSA-69306 | DNA Replication | 3.454463e-01 | 0.462 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.471913e-01 | 0.459 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.551063e-01 | 0.450 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.551063e-01 | 0.450 |
| R-HSA-9612973 | Autophagy | 3.553613e-01 | 0.449 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.569721e-01 | 0.447 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.629257e-01 | 0.440 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.629257e-01 | 0.440 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.629257e-01 | 0.440 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.685517e-01 | 0.434 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.706509e-01 | 0.431 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.706509e-01 | 0.431 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.743713e-01 | 0.427 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.782828e-01 | 0.422 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.782828e-01 | 0.422 |
| R-HSA-354192 | Integrin signaling | 3.782828e-01 | 0.422 |
| R-HSA-9930044 | Nuclear RNA decay | 3.782828e-01 | 0.422 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.782828e-01 | 0.422 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.782828e-01 | 0.422 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.782828e-01 | 0.422 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.782828e-01 | 0.422 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.786919e-01 | 0.422 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.858226e-01 | 0.414 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.858226e-01 | 0.414 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.858226e-01 | 0.414 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.858226e-01 | 0.414 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.858226e-01 | 0.414 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.915781e-01 | 0.407 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.915781e-01 | 0.407 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.932715e-01 | 0.405 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.932715e-01 | 0.405 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.932715e-01 | 0.405 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.001027e-01 | 0.398 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.001027e-01 | 0.398 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.001027e-01 | 0.398 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.006304e-01 | 0.397 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.006304e-01 | 0.397 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.077928e-01 | 0.390 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.079006e-01 | 0.389 |
| R-HSA-8853659 | RET signaling | 4.079006e-01 | 0.389 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.079006e-01 | 0.389 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.127842e-01 | 0.384 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.127842e-01 | 0.384 |
| R-HSA-9833110 | RSV-host interactions | 4.127842e-01 | 0.384 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.150830e-01 | 0.382 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.150830e-01 | 0.382 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.150830e-01 | 0.382 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.150830e-01 | 0.382 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.169822e-01 | 0.380 |
| R-HSA-421270 | Cell-cell junction organization | 4.198910e-01 | 0.377 |
| R-HSA-69239 | Synthesis of DNA | 4.253329e-01 | 0.371 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.253329e-01 | 0.371 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.253329e-01 | 0.371 |
| R-HSA-1280218 | Adaptive Immune System | 4.254498e-01 | 0.371 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.291889e-01 | 0.367 |
| R-HSA-71336 | Pentose phosphate pathway | 4.291889e-01 | 0.367 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.291889e-01 | 0.367 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.291889e-01 | 0.367 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.291889e-01 | 0.367 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.294850e-01 | 0.367 |
| R-HSA-1643685 | Disease | 4.355597e-01 | 0.361 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.361143e-01 | 0.360 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.361143e-01 | 0.360 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.361143e-01 | 0.360 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.361143e-01 | 0.360 |
| R-HSA-5260271 | Diseases of Immune System | 4.361143e-01 | 0.360 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.361143e-01 | 0.360 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 4.361143e-01 | 0.360 |
| R-HSA-2559583 | Cellular Senescence | 4.367517e-01 | 0.360 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.429562e-01 | 0.354 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.429562e-01 | 0.354 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.429562e-01 | 0.354 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.429562e-01 | 0.354 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.429562e-01 | 0.354 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.459337e-01 | 0.351 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.497155e-01 | 0.347 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.497155e-01 | 0.347 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.497155e-01 | 0.347 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.497155e-01 | 0.347 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.522170e-01 | 0.345 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.563932e-01 | 0.341 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.563932e-01 | 0.341 |
| R-HSA-9710421 | Defective pyroptosis | 4.629902e-01 | 0.334 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.629902e-01 | 0.334 |
| R-HSA-5617833 | Cilium Assembly | 4.682934e-01 | 0.329 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.714057e-01 | 0.327 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.759463e-01 | 0.322 |
| R-HSA-168249 | Innate Immune System | 4.786338e-01 | 0.320 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.823072e-01 | 0.317 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.823072e-01 | 0.317 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.823072e-01 | 0.317 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.823072e-01 | 0.317 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.823072e-01 | 0.317 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.823072e-01 | 0.317 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.823072e-01 | 0.317 |
| R-HSA-437239 | Recycling pathway of L1 | 4.885914e-01 | 0.311 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.885914e-01 | 0.311 |
| R-HSA-70263 | Gluconeogenesis | 4.947996e-01 | 0.306 |
| R-HSA-425410 | Metal ion SLC transporters | 4.947996e-01 | 0.306 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.974962e-01 | 0.303 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.995529e-01 | 0.301 |
| R-HSA-9658195 | Leishmania infection | 4.995529e-01 | 0.301 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.050773e-01 | 0.297 |
| R-HSA-9748787 | Azathioprine ADME | 5.069920e-01 | 0.295 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.089379e-01 | 0.293 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.089582e-01 | 0.293 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.089582e-01 | 0.293 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.089582e-01 | 0.293 |
| R-HSA-114608 | Platelet degranulation | 5.165046e-01 | 0.287 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.188916e-01 | 0.285 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.188916e-01 | 0.285 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.202491e-01 | 0.284 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.247338e-01 | 0.280 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.247338e-01 | 0.280 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.276802e-01 | 0.278 |
| R-HSA-9843745 | Adipogenesis | 5.350335e-01 | 0.272 |
| R-HSA-397014 | Muscle contraction | 5.376210e-01 | 0.270 |
| R-HSA-5578775 | Ion homeostasis | 5.418403e-01 | 0.266 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.418403e-01 | 0.266 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.418403e-01 | 0.266 |
| R-HSA-191859 | snRNP Assembly | 5.583341e-01 | 0.253 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.583341e-01 | 0.253 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.583341e-01 | 0.253 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.690003e-01 | 0.245 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.742370e-01 | 0.241 |
| R-HSA-1268020 | Mitochondrial protein import | 5.742370e-01 | 0.241 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.742370e-01 | 0.241 |
| R-HSA-9707616 | Heme signaling | 5.742370e-01 | 0.241 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.742370e-01 | 0.241 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.772334e-01 | 0.239 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.774828e-01 | 0.238 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.794103e-01 | 0.237 |
| R-HSA-8848021 | Signaling by PTK6 | 5.794103e-01 | 0.237 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.794103e-01 | 0.237 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.809014e-01 | 0.236 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.876578e-01 | 0.231 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.895701e-01 | 0.229 |
| R-HSA-2187338 | Visual phototransduction | 5.976414e-01 | 0.224 |
| R-HSA-196807 | Nicotinate metabolism | 5.994857e-01 | 0.222 |
| R-HSA-69242 | S Phase | 6.009290e-01 | 0.221 |
| R-HSA-166520 | Signaling by NTRKs | 6.009290e-01 | 0.221 |
| R-HSA-9758941 | Gastrulation | 6.041964e-01 | 0.219 |
| R-HSA-15869 | Metabolism of nucleotides | 6.042030e-01 | 0.219 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.043538e-01 | 0.219 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.043538e-01 | 0.219 |
| R-HSA-5218859 | Regulated Necrosis | 6.043538e-01 | 0.219 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.138778e-01 | 0.212 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.139140e-01 | 0.212 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.186075e-01 | 0.209 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.186075e-01 | 0.209 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.186075e-01 | 0.209 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.202315e-01 | 0.207 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.232443e-01 | 0.205 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.232443e-01 | 0.205 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 6.232443e-01 | 0.205 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.278250e-01 | 0.202 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.278250e-01 | 0.202 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 6.323503e-01 | 0.199 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.325386e-01 | 0.199 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.326979e-01 | 0.199 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.368209e-01 | 0.196 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.368209e-01 | 0.196 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.412373e-01 | 0.193 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 6.422609e-01 | 0.192 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.499106e-01 | 0.187 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.499106e-01 | 0.187 |
| R-HSA-216083 | Integrin cell surface interactions | 6.499106e-01 | 0.187 |
| R-HSA-5688426 | Deubiquitination | 6.522520e-01 | 0.186 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.583752e-01 | 0.182 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.583752e-01 | 0.182 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.666362e-01 | 0.176 |
| R-HSA-416476 | G alpha (q) signalling events | 6.735200e-01 | 0.172 |
| R-HSA-449147 | Signaling by Interleukins | 6.744194e-01 | 0.171 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.786564e-01 | 0.168 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.793885e-01 | 0.168 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.864293e-01 | 0.163 |
| R-HSA-9663891 | Selective autophagy | 6.940152e-01 | 0.159 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.940152e-01 | 0.159 |
| R-HSA-1266738 | Developmental Biology | 6.967484e-01 | 0.157 |
| R-HSA-73884 | Base Excision Repair | 7.014185e-01 | 0.154 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.121905e-01 | 0.147 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.191562e-01 | 0.143 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.225758e-01 | 0.141 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.292914e-01 | 0.137 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.358452e-01 | 0.133 |
| R-HSA-9609690 | HCMV Early Events | 7.379367e-01 | 0.132 |
| R-HSA-3214847 | HATs acetylate histones | 7.390626e-01 | 0.131 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.390626e-01 | 0.131 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.390626e-01 | 0.131 |
| R-HSA-168256 | Immune System | 7.413680e-01 | 0.130 |
| R-HSA-1483255 | PI Metabolism | 7.484829e-01 | 0.126 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.538591e-01 | 0.123 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.545744e-01 | 0.122 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.634374e-01 | 0.117 |
| R-HSA-211000 | Gene Silencing by RNA | 7.663204e-01 | 0.116 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.691684e-01 | 0.114 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.747613e-01 | 0.111 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.845858e-01 | 0.105 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.881606e-01 | 0.103 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.932955e-01 | 0.101 |
| R-HSA-373760 | L1CAM interactions | 7.958164e-01 | 0.099 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.983066e-01 | 0.098 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.007666e-01 | 0.096 |
| R-HSA-1474244 | Extracellular matrix organization | 8.023165e-01 | 0.096 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.059127e-01 | 0.094 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.126261e-01 | 0.090 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.126261e-01 | 0.090 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.149123e-01 | 0.089 |
| R-HSA-157118 | Signaling by NOTCH | 8.264751e-01 | 0.083 |
| R-HSA-199991 | Membrane Trafficking | 8.272556e-01 | 0.082 |
| R-HSA-9717189 | Sensory perception of taste | 8.342788e-01 | 0.079 |
| R-HSA-5576891 | Cardiac conduction | 8.342788e-01 | 0.079 |
| R-HSA-9609646 | HCMV Infection | 8.420984e-01 | 0.075 |
| R-HSA-392499 | Metabolism of proteins | 8.448472e-01 | 0.073 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.719812e-01 | 0.059 |
| R-HSA-9609507 | Protein localization | 8.766194e-01 | 0.057 |
| R-HSA-73887 | Death Receptor Signaling | 8.781280e-01 | 0.056 |
| R-HSA-597592 | Post-translational protein modification | 8.789215e-01 | 0.056 |
| R-HSA-1989781 | PPARA activates gene expression | 8.796183e-01 | 0.056 |
| R-HSA-9610379 | HCMV Late Events | 8.825446e-01 | 0.054 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.825446e-01 | 0.054 |
| R-HSA-877300 | Interferon gamma signaling | 8.854002e-01 | 0.053 |
| R-HSA-5619102 | SLC transporter disorders | 8.961480e-01 | 0.048 |
| R-HSA-72306 | tRNA processing | 9.011397e-01 | 0.045 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.058926e-01 | 0.043 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.070449e-01 | 0.042 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.078168e-01 | 0.042 |
| R-HSA-611105 | Respiratory electron transport | 9.104181e-01 | 0.041 |
| R-HSA-983712 | Ion channel transport | 9.217773e-01 | 0.035 |
| R-HSA-6805567 | Keratinization | 9.373554e-01 | 0.028 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.404789e-01 | 0.027 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.410018e-01 | 0.026 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.425426e-01 | 0.026 |
| R-HSA-9748784 | Drug ADME | 9.459839e-01 | 0.024 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.534291e-01 | 0.021 |
| R-HSA-9679506 | SARS-CoV Infections | 9.725766e-01 | 0.012 |
| R-HSA-1483257 | Phospholipid metabolism | 9.791847e-01 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 9.844995e-01 | 0.007 |
| R-HSA-8957322 | Metabolism of steroids | 9.854827e-01 | 0.006 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.911783e-01 | 0.004 |
| R-HSA-1430728 | Metabolism | 9.938474e-01 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.942292e-01 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 9.999816e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999990e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.854 | 0.153 | 2 | 0.874 |
MLK1 |
0.846 | 0.288 | 2 | 0.897 |
MLK3 |
0.845 | 0.388 | 2 | 0.881 |
MST4 |
0.843 | 0.267 | 2 | 0.893 |
PKN2 |
0.841 | 0.235 | -3 | 0.855 |
PKN3 |
0.841 | 0.170 | -3 | 0.844 |
PKCD |
0.841 | 0.259 | 2 | 0.893 |
DSTYK |
0.840 | 0.113 | 2 | 0.897 |
NEK6 |
0.840 | 0.170 | -2 | 0.854 |
GCN2 |
0.838 | -0.005 | 2 | 0.805 |
CLK3 |
0.838 | 0.166 | 1 | 0.802 |
PKCA |
0.836 | 0.274 | 2 | 0.875 |
PKCB |
0.836 | 0.274 | 2 | 0.886 |
MTOR |
0.836 | 0.047 | 1 | 0.768 |
NLK |
0.835 | 0.111 | 1 | 0.788 |
PKCG |
0.835 | 0.273 | 2 | 0.879 |
ULK2 |
0.835 | 0.046 | 2 | 0.805 |
PRPK |
0.834 | -0.029 | -1 | 0.866 |
NUAK2 |
0.834 | 0.119 | -3 | 0.850 |
CDKL1 |
0.833 | 0.099 | -3 | 0.803 |
IRE1 |
0.833 | 0.190 | 1 | 0.779 |
PKCH |
0.832 | 0.257 | 2 | 0.862 |
WNK1 |
0.832 | 0.128 | -2 | 0.891 |
MOS |
0.832 | 0.026 | 1 | 0.814 |
NEK7 |
0.832 | 0.056 | -3 | 0.869 |
IRE2 |
0.831 | 0.199 | 2 | 0.832 |
CDC7 |
0.830 | -0.044 | 1 | 0.802 |
MLK4 |
0.830 | 0.222 | 2 | 0.829 |
RAF1 |
0.830 | -0.050 | 1 | 0.828 |
CDKL5 |
0.829 | 0.108 | -3 | 0.794 |
BMPR2 |
0.828 | -0.003 | -2 | 0.888 |
PIM3 |
0.828 | 0.010 | -3 | 0.847 |
NIK |
0.827 | 0.120 | -3 | 0.902 |
TGFBR2 |
0.827 | 0.043 | -2 | 0.785 |
ERK5 |
0.827 | 0.032 | 1 | 0.761 |
NEK9 |
0.827 | 0.088 | 2 | 0.876 |
CAMK1B |
0.826 | -0.012 | -3 | 0.873 |
RIPK3 |
0.826 | 0.011 | 3 | 0.701 |
TBK1 |
0.825 | -0.083 | 1 | 0.742 |
MLK2 |
0.825 | 0.117 | 2 | 0.861 |
ATR |
0.825 | -0.011 | 1 | 0.826 |
IKKB |
0.824 | -0.121 | -2 | 0.748 |
PHKG1 |
0.824 | 0.156 | -3 | 0.845 |
CDK5 |
0.824 | 0.146 | 1 | 0.635 |
ULK1 |
0.823 | -0.037 | -3 | 0.856 |
CAMK2G |
0.823 | -0.088 | 2 | 0.748 |
CHAK2 |
0.823 | 0.026 | -1 | 0.823 |
PDHK4 |
0.822 | -0.245 | 1 | 0.826 |
PKCZ |
0.822 | 0.168 | 2 | 0.862 |
TSSK2 |
0.821 | 0.052 | -5 | 0.857 |
PRKD2 |
0.821 | 0.050 | -3 | 0.770 |
CDK2 |
0.821 | 0.167 | 1 | 0.657 |
GRK5 |
0.821 | -0.075 | -3 | 0.897 |
IKKE |
0.820 | -0.113 | 1 | 0.727 |
PDHK1 |
0.820 | -0.170 | 1 | 0.820 |
ANKRD3 |
0.819 | 0.048 | 1 | 0.856 |
MNK2 |
0.819 | 0.086 | -2 | 0.792 |
PKCT |
0.819 | 0.212 | 2 | 0.861 |
MAPKAPK3 |
0.819 | 0.015 | -3 | 0.791 |
PIM1 |
0.819 | 0.038 | -3 | 0.794 |
PKR |
0.819 | 0.159 | 1 | 0.821 |
NEK2 |
0.819 | 0.121 | 2 | 0.856 |
PKCE |
0.818 | 0.279 | 2 | 0.875 |
PRKD1 |
0.818 | -0.015 | -3 | 0.835 |
CHAK1 |
0.818 | 0.142 | 2 | 0.780 |
HUNK |
0.818 | -0.091 | 2 | 0.783 |
MST3 |
0.818 | 0.315 | 2 | 0.901 |
CDK1 |
0.818 | 0.113 | 1 | 0.573 |
WNK3 |
0.817 | -0.100 | 1 | 0.809 |
ICK |
0.817 | 0.040 | -3 | 0.843 |
BCKDK |
0.816 | -0.114 | -1 | 0.826 |
SRPK1 |
0.816 | 0.048 | -3 | 0.745 |
AMPKA1 |
0.816 | -0.031 | -3 | 0.871 |
GRK6 |
0.816 | -0.052 | 1 | 0.821 |
TSSK1 |
0.815 | 0.013 | -3 | 0.886 |
NUAK1 |
0.815 | 0.034 | -3 | 0.799 |
PHKG2 |
0.815 | 0.162 | -3 | 0.804 |
RSK2 |
0.815 | -0.002 | -3 | 0.766 |
CAMLCK |
0.815 | -0.046 | -2 | 0.850 |
DLK |
0.815 | -0.051 | 1 | 0.823 |
HRI |
0.814 | 0.125 | -2 | 0.842 |
NDR1 |
0.814 | -0.054 | -3 | 0.849 |
YSK4 |
0.814 | 0.086 | 1 | 0.758 |
NDR2 |
0.813 | -0.100 | -3 | 0.854 |
TTBK2 |
0.813 | -0.080 | 2 | 0.732 |
CDK3 |
0.813 | 0.168 | 1 | 0.511 |
CAMK4 |
0.813 | -0.017 | -3 | 0.841 |
CDK8 |
0.813 | -0.007 | 1 | 0.610 |
MNK1 |
0.813 | 0.082 | -2 | 0.803 |
EEF2K |
0.812 | 0.322 | 3 | 0.875 |
KIS |
0.812 | -0.016 | 1 | 0.643 |
BMPR1B |
0.812 | 0.063 | 1 | 0.768 |
PRKD3 |
0.812 | 0.044 | -3 | 0.740 |
DAPK2 |
0.812 | -0.073 | -3 | 0.881 |
ATM |
0.811 | -0.022 | 1 | 0.779 |
ZAK |
0.811 | 0.150 | 1 | 0.784 |
PKCI |
0.811 | 0.188 | 2 | 0.849 |
MARK4 |
0.811 | -0.104 | 4 | 0.634 |
CAMK2D |
0.811 | -0.081 | -3 | 0.859 |
SKMLCK |
0.811 | -0.076 | -2 | 0.857 |
P90RSK |
0.811 | -0.035 | -3 | 0.774 |
GRK1 |
0.810 | -0.055 | -2 | 0.797 |
RSK3 |
0.810 | -0.018 | -3 | 0.765 |
IRAK4 |
0.810 | 0.137 | 1 | 0.808 |
PLK1 |
0.810 | -0.043 | -2 | 0.803 |
AMPKA2 |
0.810 | -0.031 | -3 | 0.832 |
IKKA |
0.809 | -0.118 | -2 | 0.737 |
P70S6KB |
0.809 | -0.029 | -3 | 0.802 |
QIK |
0.809 | -0.032 | -3 | 0.850 |
MASTL |
0.809 | -0.226 | -2 | 0.824 |
NIM1 |
0.809 | -0.055 | 3 | 0.742 |
MEKK2 |
0.809 | 0.167 | 2 | 0.842 |
SRPK2 |
0.809 | 0.043 | -3 | 0.669 |
PKACG |
0.809 | -0.025 | -2 | 0.764 |
CDK19 |
0.808 | 0.000 | 1 | 0.572 |
RIPK1 |
0.808 | -0.138 | 1 | 0.824 |
MEKK3 |
0.808 | 0.062 | 1 | 0.790 |
GRK4 |
0.807 | -0.140 | -2 | 0.822 |
CDK18 |
0.807 | 0.051 | 1 | 0.548 |
MAPKAPK2 |
0.807 | -0.016 | -3 | 0.736 |
MELK |
0.807 | -0.020 | -3 | 0.817 |
ALK4 |
0.807 | -0.041 | -2 | 0.825 |
FAM20C |
0.807 | -0.028 | 2 | 0.524 |
DRAK1 |
0.806 | 0.034 | 1 | 0.787 |
TAO3 |
0.806 | 0.174 | 1 | 0.780 |
CDK16 |
0.806 | 0.129 | 1 | 0.512 |
SRPK3 |
0.806 | 0.030 | -3 | 0.721 |
PKN1 |
0.805 | 0.153 | -3 | 0.727 |
PERK |
0.805 | 0.013 | -2 | 0.826 |
GRK7 |
0.805 | 0.014 | 1 | 0.755 |
P38A |
0.805 | 0.043 | 1 | 0.654 |
CLK1 |
0.805 | 0.061 | -3 | 0.742 |
HIPK4 |
0.805 | -0.049 | 1 | 0.735 |
CDK13 |
0.805 | -0.002 | 1 | 0.591 |
ERK1 |
0.804 | 0.041 | 1 | 0.577 |
TNIK |
0.804 | 0.316 | 3 | 0.888 |
MEKK1 |
0.804 | 0.018 | 1 | 0.803 |
TAO2 |
0.804 | 0.219 | 2 | 0.903 |
AKT2 |
0.804 | 0.063 | -3 | 0.681 |
CAMK2B |
0.804 | -0.066 | 2 | 0.699 |
AURC |
0.804 | 0.002 | -2 | 0.665 |
ACVR2A |
0.803 | -0.009 | -2 | 0.776 |
ERK7 |
0.803 | 0.127 | 2 | 0.664 |
SGK3 |
0.803 | 0.037 | -3 | 0.770 |
ERK2 |
0.802 | 0.025 | 1 | 0.622 |
NEK8 |
0.802 | 0.152 | 2 | 0.873 |
MEK1 |
0.802 | -0.128 | 2 | 0.793 |
TGFBR1 |
0.802 | -0.043 | -2 | 0.796 |
PKG2 |
0.802 | 0.025 | -2 | 0.701 |
NEK5 |
0.802 | 0.061 | 1 | 0.831 |
LATS2 |
0.801 | -0.105 | -5 | 0.677 |
WNK4 |
0.801 | 0.006 | -2 | 0.882 |
MEK5 |
0.801 | 0.011 | 2 | 0.827 |
PAK1 |
0.801 | -0.062 | -2 | 0.781 |
CDK7 |
0.801 | -0.029 | 1 | 0.615 |
VRK2 |
0.801 | -0.166 | 1 | 0.841 |
PINK1 |
0.801 | -0.018 | 1 | 0.784 |
PAK3 |
0.800 | -0.081 | -2 | 0.778 |
CK1E |
0.800 | 0.038 | -3 | 0.619 |
PAK6 |
0.800 | 0.012 | -2 | 0.694 |
CLK4 |
0.800 | 0.009 | -3 | 0.772 |
CAMK2A |
0.800 | -0.063 | 2 | 0.728 |
CDK10 |
0.799 | 0.101 | 1 | 0.583 |
NEK11 |
0.799 | 0.135 | 1 | 0.803 |
CAMK1G |
0.799 | -0.015 | -3 | 0.766 |
HGK |
0.799 | 0.241 | 3 | 0.874 |
CHK1 |
0.799 | -0.044 | -3 | 0.849 |
CDK14 |
0.799 | 0.066 | 1 | 0.596 |
DNAPK |
0.799 | -0.015 | 1 | 0.726 |
CDK17 |
0.799 | 0.022 | 1 | 0.494 |
BRAF |
0.799 | -0.043 | -4 | 0.753 |
ALK2 |
0.798 | -0.034 | -2 | 0.806 |
SMG1 |
0.798 | -0.054 | 1 | 0.777 |
MINK |
0.798 | 0.234 | 1 | 0.791 |
ACVR2B |
0.798 | -0.042 | -2 | 0.785 |
MYLK4 |
0.798 | -0.041 | -2 | 0.763 |
PLK3 |
0.797 | -0.075 | 2 | 0.713 |
SNRK |
0.797 | -0.115 | 2 | 0.673 |
PIM2 |
0.797 | 0.017 | -3 | 0.745 |
P38G |
0.797 | 0.009 | 1 | 0.487 |
RSK4 |
0.796 | -0.029 | -3 | 0.735 |
LATS1 |
0.796 | -0.071 | -3 | 0.866 |
QSK |
0.796 | -0.091 | 4 | 0.626 |
CDK12 |
0.796 | -0.008 | 1 | 0.566 |
AKT1 |
0.796 | 0.065 | -3 | 0.703 |
AURB |
0.796 | -0.020 | -2 | 0.656 |
MSK2 |
0.796 | -0.081 | -3 | 0.750 |
PRP4 |
0.796 | 0.023 | -3 | 0.805 |
JNK2 |
0.796 | -0.005 | 1 | 0.569 |
JNK3 |
0.796 | -0.023 | 1 | 0.599 |
MPSK1 |
0.796 | 0.078 | 1 | 0.755 |
SIK |
0.796 | -0.073 | -3 | 0.771 |
CDK6 |
0.796 | 0.097 | 1 | 0.577 |
P38B |
0.796 | 0.014 | 1 | 0.581 |
CDK9 |
0.795 | -0.030 | 1 | 0.603 |
NEK4 |
0.795 | 0.119 | 1 | 0.793 |
GCK |
0.794 | 0.162 | 1 | 0.787 |
BRSK2 |
0.794 | -0.105 | -3 | 0.835 |
DCAMKL2 |
0.794 | 0.011 | -3 | 0.815 |
PLK4 |
0.794 | -0.080 | 2 | 0.605 |
GRK2 |
0.793 | -0.064 | -2 | 0.712 |
MAP3K15 |
0.793 | 0.148 | 1 | 0.769 |
DYRK2 |
0.793 | -0.047 | 1 | 0.628 |
SSTK |
0.793 | -0.025 | 4 | 0.626 |
MST2 |
0.792 | 0.094 | 1 | 0.791 |
KHS2 |
0.792 | 0.224 | 1 | 0.785 |
AURA |
0.792 | -0.030 | -2 | 0.612 |
BRSK1 |
0.792 | -0.100 | -3 | 0.804 |
DCAMKL1 |
0.792 | -0.023 | -3 | 0.794 |
TTBK1 |
0.792 | -0.070 | 2 | 0.651 |
MEKK6 |
0.792 | 0.130 | 1 | 0.775 |
PAK2 |
0.792 | -0.108 | -2 | 0.764 |
YSK1 |
0.792 | 0.213 | 2 | 0.878 |
IRAK1 |
0.791 | -0.073 | -1 | 0.784 |
SMMLCK |
0.791 | -0.016 | -3 | 0.824 |
BMPR1A |
0.791 | 0.005 | 1 | 0.749 |
TLK1 |
0.791 | -0.078 | -2 | 0.816 |
GAK |
0.791 | 0.052 | 1 | 0.815 |
MARK3 |
0.791 | -0.100 | 4 | 0.589 |
TAK1 |
0.791 | 0.136 | 1 | 0.833 |
HPK1 |
0.790 | 0.151 | 1 | 0.776 |
HIPK1 |
0.790 | 0.001 | 1 | 0.650 |
TLK2 |
0.790 | -0.157 | 1 | 0.775 |
MARK2 |
0.790 | -0.127 | 4 | 0.547 |
PKACB |
0.790 | -0.027 | -2 | 0.684 |
KHS1 |
0.789 | 0.194 | 1 | 0.771 |
LOK |
0.789 | 0.132 | -2 | 0.785 |
MST1 |
0.789 | 0.156 | 1 | 0.777 |
MAPKAPK5 |
0.789 | -0.107 | -3 | 0.737 |
NEK1 |
0.789 | 0.130 | 1 | 0.809 |
CAMKK1 |
0.788 | -0.047 | -2 | 0.762 |
GSK3B |
0.788 | -0.062 | 4 | 0.323 |
GSK3A |
0.787 | -0.040 | 4 | 0.332 |
PDK1 |
0.787 | 0.013 | 1 | 0.830 |
LRRK2 |
0.787 | 0.085 | 2 | 0.860 |
HIPK3 |
0.787 | -0.015 | 1 | 0.657 |
CLK2 |
0.787 | 0.009 | -3 | 0.752 |
MSK1 |
0.787 | -0.080 | -3 | 0.755 |
PRKX |
0.786 | -0.000 | -3 | 0.676 |
HIPK2 |
0.786 | -0.004 | 1 | 0.539 |
CK1D |
0.786 | 0.012 | -3 | 0.570 |
MARK1 |
0.785 | -0.125 | 4 | 0.608 |
CDK4 |
0.785 | 0.039 | 1 | 0.550 |
DYRK1A |
0.784 | -0.031 | 1 | 0.686 |
HASPIN |
0.784 | 0.142 | -1 | 0.687 |
MYO3B |
0.783 | 0.259 | 2 | 0.880 |
CHK2 |
0.783 | 0.025 | -3 | 0.627 |
CK1G1 |
0.782 | -0.035 | -3 | 0.609 |
BUB1 |
0.782 | 0.119 | -5 | 0.724 |
MYO3A |
0.781 | 0.287 | 1 | 0.766 |
CK1A2 |
0.781 | 0.002 | -3 | 0.567 |
SLK |
0.781 | 0.047 | -2 | 0.728 |
P38D |
0.780 | -0.011 | 1 | 0.507 |
AKT3 |
0.780 | 0.044 | -3 | 0.615 |
CAMK1D |
0.780 | -0.049 | -3 | 0.693 |
P70S6K |
0.780 | -0.065 | -3 | 0.708 |
PKACA |
0.780 | -0.022 | -2 | 0.637 |
PASK |
0.779 | -0.105 | -3 | 0.862 |
TAO1 |
0.779 | 0.172 | 1 | 0.719 |
CAMKK2 |
0.779 | -0.090 | -2 | 0.757 |
LKB1 |
0.778 | -0.093 | -3 | 0.881 |
VRK1 |
0.778 | -0.054 | 2 | 0.832 |
OSR1 |
0.777 | 0.113 | 2 | 0.813 |
GRK3 |
0.777 | -0.074 | -2 | 0.662 |
RIPK2 |
0.776 | -0.090 | 1 | 0.753 |
TTK |
0.776 | 0.112 | -2 | 0.812 |
CAMK1A |
0.775 | -0.011 | -3 | 0.644 |
DYRK3 |
0.774 | -0.047 | 1 | 0.647 |
NEK3 |
0.774 | 0.011 | 1 | 0.763 |
CK2A2 |
0.774 | -0.025 | 1 | 0.631 |
STK33 |
0.774 | -0.077 | 2 | 0.634 |
PAK5 |
0.774 | -0.067 | -2 | 0.624 |
MRCKB |
0.773 | 0.008 | -3 | 0.739 |
PLK2 |
0.773 | -0.053 | -3 | 0.836 |
MAK |
0.772 | 0.064 | -2 | 0.808 |
DYRK1B |
0.770 | -0.065 | 1 | 0.579 |
SGK1 |
0.770 | -0.004 | -3 | 0.601 |
MOK |
0.770 | 0.040 | 1 | 0.663 |
DYRK4 |
0.770 | -0.062 | 1 | 0.553 |
DAPK3 |
0.770 | -0.076 | -3 | 0.807 |
ROCK2 |
0.770 | 0.001 | -3 | 0.800 |
BIKE |
0.767 | 0.071 | 1 | 0.693 |
MEK2 |
0.767 | -0.147 | 2 | 0.775 |
MRCKA |
0.767 | -0.030 | -3 | 0.763 |
PAK4 |
0.766 | -0.076 | -2 | 0.629 |
ASK1 |
0.766 | 0.067 | 1 | 0.756 |
PBK |
0.765 | -0.008 | 1 | 0.727 |
JNK1 |
0.765 | -0.065 | 1 | 0.546 |
CK2A1 |
0.765 | -0.040 | 1 | 0.607 |
DMPK1 |
0.763 | 0.020 | -3 | 0.756 |
DAPK1 |
0.763 | -0.087 | -3 | 0.788 |
TESK1_TYR |
0.762 | 0.069 | 3 | 0.850 |
PINK1_TYR |
0.762 | 0.093 | 1 | 0.816 |
PDHK3_TYR |
0.762 | -0.052 | 4 | 0.698 |
ROCK1 |
0.760 | 0.005 | -3 | 0.763 |
PKG1 |
0.759 | -0.033 | -2 | 0.622 |
PKMYT1_TYR |
0.758 | -0.025 | 3 | 0.806 |
LIMK2_TYR |
0.758 | 0.087 | -3 | 0.913 |
SBK |
0.757 | -0.040 | -3 | 0.554 |
TYK2 |
0.757 | 0.054 | 1 | 0.798 |
ROS1 |
0.757 | 0.066 | 3 | 0.746 |
MAP2K7_TYR |
0.756 | -0.145 | 2 | 0.823 |
TNNI3K_TYR |
0.756 | 0.156 | 1 | 0.805 |
BMPR2_TYR |
0.756 | -0.034 | -1 | 0.880 |
ALPHAK3 |
0.755 | -0.028 | -1 | 0.786 |
PDHK4_TYR |
0.755 | -0.096 | 2 | 0.819 |
LIMK1_TYR |
0.755 | 0.040 | 2 | 0.848 |
MAP2K6_TYR |
0.754 | -0.117 | -1 | 0.894 |
TYRO3 |
0.754 | -0.000 | 3 | 0.778 |
RET |
0.753 | -0.031 | 1 | 0.796 |
EPHA6 |
0.753 | 0.018 | -1 | 0.861 |
MAP2K4_TYR |
0.753 | -0.194 | -1 | 0.881 |
PDHK1_TYR |
0.752 | -0.101 | -1 | 0.897 |
JAK2 |
0.752 | -0.003 | 1 | 0.802 |
CSF1R |
0.751 | -0.014 | 3 | 0.748 |
WEE1_TYR |
0.751 | 0.135 | -1 | 0.771 |
MST1R |
0.751 | -0.049 | 3 | 0.758 |
AAK1 |
0.750 | 0.086 | 1 | 0.592 |
YANK3 |
0.750 | -0.064 | 2 | 0.407 |
ABL2 |
0.749 | 0.010 | -1 | 0.818 |
LCK |
0.748 | 0.082 | -1 | 0.828 |
FGR |
0.748 | -0.008 | 1 | 0.832 |
FLT3 |
0.747 | 0.005 | 3 | 0.767 |
JAK1 |
0.747 | 0.080 | 1 | 0.748 |
STLK3 |
0.747 | -0.100 | 1 | 0.744 |
CRIK |
0.747 | -0.052 | -3 | 0.696 |
ITK |
0.746 | 0.010 | -1 | 0.816 |
HCK |
0.746 | 0.014 | -1 | 0.823 |
JAK3 |
0.746 | -0.024 | 1 | 0.778 |
EPHB4 |
0.746 | -0.069 | -1 | 0.848 |
PDGFRB |
0.745 | -0.034 | 3 | 0.764 |
TXK |
0.744 | -0.001 | 1 | 0.798 |
CK1A |
0.744 | -0.045 | -3 | 0.479 |
KDR |
0.743 | 0.005 | 3 | 0.703 |
BLK |
0.743 | 0.044 | -1 | 0.828 |
ABL1 |
0.743 | -0.017 | -1 | 0.805 |
YES1 |
0.742 | -0.054 | -1 | 0.820 |
DDR1 |
0.742 | -0.157 | 4 | 0.647 |
FER |
0.742 | -0.102 | 1 | 0.843 |
PDGFRA |
0.742 | -0.036 | 3 | 0.773 |
TNK1 |
0.741 | -0.008 | 3 | 0.747 |
TEC |
0.740 | -0.007 | -1 | 0.722 |
KIT |
0.740 | -0.076 | 3 | 0.743 |
INSRR |
0.740 | -0.101 | 3 | 0.696 |
NEK10_TYR |
0.739 | -0.023 | 1 | 0.679 |
BTK |
0.738 | -0.043 | -1 | 0.773 |
EPHB1 |
0.737 | -0.103 | 1 | 0.822 |
EPHA4 |
0.736 | -0.086 | 2 | 0.705 |
FLT1 |
0.736 | -0.023 | -1 | 0.862 |
SRMS |
0.735 | -0.122 | 1 | 0.826 |
EPHB3 |
0.735 | -0.104 | -1 | 0.837 |
BMX |
0.735 | -0.048 | -1 | 0.719 |
FRK |
0.734 | -0.021 | -1 | 0.838 |
MET |
0.734 | -0.096 | 3 | 0.719 |
LYN |
0.733 | -0.017 | 3 | 0.683 |
TNK2 |
0.733 | -0.121 | 3 | 0.679 |
AXL |
0.732 | -0.121 | 3 | 0.715 |
ALK |
0.732 | -0.094 | 3 | 0.665 |
EPHB2 |
0.732 | -0.104 | -1 | 0.832 |
TEK |
0.732 | -0.137 | 3 | 0.696 |
PTK6 |
0.732 | -0.119 | -1 | 0.758 |
FGFR2 |
0.732 | -0.174 | 3 | 0.720 |
MERTK |
0.731 | -0.109 | 3 | 0.711 |
FYN |
0.730 | -0.022 | -1 | 0.791 |
FLT4 |
0.730 | -0.088 | 3 | 0.697 |
FGFR1 |
0.730 | -0.164 | 3 | 0.708 |
ERBB2 |
0.730 | -0.106 | 1 | 0.748 |
EPHA7 |
0.728 | -0.083 | 2 | 0.725 |
LTK |
0.728 | -0.108 | 3 | 0.680 |
EPHA1 |
0.726 | -0.103 | 3 | 0.696 |
NTRK2 |
0.726 | -0.140 | 3 | 0.703 |
INSR |
0.726 | -0.126 | 3 | 0.682 |
MATK |
0.726 | -0.064 | -1 | 0.755 |
MUSK |
0.725 | -0.000 | 1 | 0.640 |
NTRK1 |
0.724 | -0.202 | -1 | 0.829 |
CK1G3 |
0.724 | -0.047 | -3 | 0.428 |
EPHA3 |
0.724 | -0.137 | 2 | 0.693 |
YANK2 |
0.722 | -0.065 | 2 | 0.432 |
FGFR3 |
0.720 | -0.174 | 3 | 0.693 |
NTRK3 |
0.719 | -0.150 | -1 | 0.787 |
SRC |
0.719 | -0.089 | -1 | 0.784 |
CSK |
0.719 | -0.120 | 2 | 0.734 |
EGFR |
0.718 | -0.090 | 1 | 0.670 |
EPHA8 |
0.717 | -0.106 | -1 | 0.825 |
DDR2 |
0.717 | -0.136 | 3 | 0.667 |
PTK2B |
0.717 | -0.116 | -1 | 0.763 |
EPHA5 |
0.716 | -0.131 | 2 | 0.691 |
PTK2 |
0.716 | -0.042 | -1 | 0.779 |
SYK |
0.715 | -0.041 | -1 | 0.791 |
IGF1R |
0.707 | -0.154 | 3 | 0.619 |
FGFR4 |
0.706 | -0.156 | -1 | 0.790 |
EPHA2 |
0.706 | -0.130 | -1 | 0.792 |
CK1G2 |
0.703 | -0.065 | -3 | 0.526 |
ERBB4 |
0.703 | -0.102 | 1 | 0.675 |
FES |
0.693 | -0.155 | -1 | 0.696 |
ZAP70 |
0.688 | -0.075 | -1 | 0.717 |