Motif 754 (n=65)

Position-wise Probabilities

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uniprot genes site source protein function
A4UGR9 XIRP2 S2717 ochoa Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}.
A6NKT7 RGPD3 S1608 ochoa RanBP2-like and GRIP domain-containing protein 3 None
A6NMY6 ANXA2P2 S127 ochoa Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}.
H0YC42 None S171 ochoa Tumor protein D52 None
O00193 SMAP S82 ochoa Small acidic protein None
O00418 EEF2K S243 ochoa Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}.
O14715 RGPD8 S1607 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O15061 SYNM S699 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15234 CASC3 T143 ochoa Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.
O75717 WDHD1 S888 ochoa WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
P07355 ANXA2 S127 ochoa Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}.
P07814 EPRS1 S330 ochoa Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}.
P0DJD0 RGPD1 S1592 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1600 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P10244 MYBL2 S282 ochoa Myb-related protein B (B-Myb) (Myb-like protein 2) Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.
P16435 POR S63 ochoa NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP-Rule:MF_03212}.
P27816 MAP4 S71 ochoa Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
P30414 NKTR S1077 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P35749 MYH11 T1368 ochoa Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
P46100 ATRX S651 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46821 MAP1B S1421 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P48651 PTDSS1 S454 ochoa Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269|PubMed:19014349, ECO:0000269|PubMed:24241535}.
P49792 RANBP2 S2583 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50851 LRBA S1231 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
Q12912 IRAG2 S182 ochoa Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}.
Q12912 IRAG2 S447 ochoa Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}.
Q13416 ORC2 S255 ochoa Origin recognition complex subunit 2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Q15311 RALBP1 S93 ochoa RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}.
Q2M2Z5 KIZ S618 ochoa Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}.
Q53EL6 PDCD4 S49 ochoa Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
Q5SW79 CEP170 S1079 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T200 ZC3H13 S1017 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5VZK9 CARMIL1 S1068 ochoa F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.
Q76FK4 NOL8 S268 ochoa Nucleolar protein 8 (Nucleolar protein Nop132) Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.
Q7Z3J3 RGPD4 S1608 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z6E9 RBBP6 S1341 ochoa E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}.
Q8NDI1 EHBP1 S730 ochoa EH domain-binding protein 1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.
Q96EB6 SIRT1 S590 ochoa NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}.
Q96RS0 TGS1 S158 ochoa Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
Q99666 RGPD5 S1607 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9H0A0 NAT10 S984 ochoa RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}.
Q9H1H9 KIF13A S1734 ochoa Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.
Q9H582 ZNF644 S828 ochoa Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) May be involved in transcriptional regulation.
Q9HAU0 PLEKHA5 S126 ochoa Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) None
Q9HCE3 ZNF532 S1256 ochoa Zinc finger protein 532 May be involved in transcriptional regulation.
Q9HCE5 METTL14 S54 ochoa N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14) The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27281194, PubMed:27373337, PubMed:29348140). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}.
Q9UEE5 STK17A S348 ochoa Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}.
Q9UKX2 MYH2 S1239 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9ULU4 ZMYND8 S460 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9UN81 L1RE1 S145 ochoa LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}.
Q9Y3P9 RABGAP1 S37 ochoa Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}.
Q9Y4W2 LAS1L S238 ochoa Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}.
Q9Y520 PRRC2C S376 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9BR76 CORO1B S391 Sugiyama Coronin-1B (Coronin-2) Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}.
Q9ULV4 CORO1C S389 Sugiyama Coronin-1C (Coronin-3) (hCRNN4) Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}.
O75391 SPAG7 S57 Sugiyama Sperm-associated antigen 7 None
Q02790 FKBP4 T278 Sugiyama Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
P68104 EEF1A1 S53 SIGNOR Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}.
Q05639 EEF1A2 S53 SIGNOR Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}.
Q07866 KLC1 S445 Sugiyama Kinesin light chain 1 (KLC 1) Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}.
P33778 H2BC3 S33 EPSD Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P62807 H2BC4 S33 ELM Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
P27797 CALR S53 Sugiyama Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.
P42704 LRPPRC S1027 Sugiyama Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}.
Q9HBH9 MKNK2 S338 Sugiyama MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}.
Download
reactome_id name p -log10_p
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.000003 5.511
R-HSA-427359 SIRT1 negatively regulates rRNA expression 0.000002 5.649
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.000001 5.903
R-HSA-171306 Packaging Of Telomere Ends 0.000019 4.719
R-HSA-73728 RNA Polymerase I Promoter Opening 0.000019 4.719
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 0.000013 4.880
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.000016 4.803
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.000018 4.742
R-HSA-5334118 DNA methylation 0.000024 4.620
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.000044 4.354
R-HSA-5578749 Transcriptional regulation by small RNAs 0.000039 4.408
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 0.000033 4.482
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.000035 4.459
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.000044 4.354
R-HSA-212300 PRC2 methylates histones and DNA 0.000053 4.275
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.000061 4.213
R-HSA-110331 Cleavage of the damaged purine 0.000058 4.236
R-HSA-73927 Depurination 0.000063 4.199
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.000081 4.091
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.000075 4.126
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 0.000081 4.091
R-HSA-110329 Cleavage of the damaged pyrimidine 0.000095 4.023
R-HSA-73928 Depyrimidination 0.000095 4.023
R-HSA-9710421 Defective pyroptosis 0.000102 3.991
R-HSA-2299718 Condensation of Prophase Chromosomes 0.000127 3.896
R-HSA-774815 Nucleosome assembly 0.000118 3.927
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.000118 3.927
R-HSA-68867 Assembly of the pre-replicative complex 0.000127 3.895
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.000146 3.836
R-HSA-1221632 Meiotic synapsis 0.000202 3.695
R-HSA-73772 RNA Polymerase I Promoter Escape 0.000190 3.722
R-HSA-912446 Meiotic recombination 0.000178 3.750
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.000202 3.695
R-HSA-3214847 HATs acetylate histones 0.000173 3.763
R-HSA-157579 Telomere Maintenance 0.000159 3.800
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.000190 3.722
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.000215 3.668
R-HSA-3214815 HDACs deacetylate histones 0.000228 3.642
R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism 0.000264 3.579
R-HSA-211000 Gene Silencing by RNA 0.000248 3.606
R-HSA-69002 DNA Replication Pre-Initiation 0.000267 3.573
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.000288 3.541
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.000304 3.517
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.000339 3.469
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.000339 3.469
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.000462 3.336
R-HSA-5693606 DNA Double Strand Break Response 0.000439 3.357
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.000418 3.379
R-HSA-3371556 Cellular response to heat stress 0.000439 3.357
R-HSA-68875 Mitotic Prophase 0.000425 3.372
R-HSA-73886 Chromosome Maintenance 0.000439 3.357
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.000397 3.401
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.000509 3.294
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.000517 3.286
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.000517 3.286
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.000517 3.286
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.000533 3.273
R-HSA-427413 NoRC negatively regulates rRNA expression 0.000533 3.273
R-HSA-69473 G2/M DNA damage checkpoint 0.000613 3.213
R-HSA-69481 G2/M Checkpoints 0.000551 3.259
R-HSA-8852135 Protein ubiquitination 0.000641 3.193
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.000670 3.174
R-HSA-9020591 Interleukin-12 signaling 0.000670 3.174
R-HSA-73864 RNA Polymerase I Transcription 0.000731 3.136
R-HSA-9018519 Estrogen-dependent gene expression 0.000770 3.114
R-HSA-5693607 Processing of DNA double-strand break ends 0.000830 3.081
R-HSA-977225 Amyloid fiber formation 0.000830 3.081
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.000844 3.074
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.000865 3.063
R-HSA-1500620 Meiosis 0.000976 3.011
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.000938 3.028
R-HSA-447115 Interleukin-12 family signaling 0.001096 2.960
R-HSA-9645723 Diseases of programmed cell death 0.001138 2.944
R-HSA-73884 Base Excision Repair 0.001227 2.911
R-HSA-69306 DNA Replication 0.001258 2.900
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.001273 2.895
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.001291 2.889
R-HSA-69620 Cell Cycle Checkpoints 0.001928 2.715
R-HSA-9842860 Regulation of endogenous retroelements 0.001983 2.703
R-HSA-2559580 Oxidative Stress Induced Senescence 0.001983 2.703
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.002082 2.681
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.002082 2.681
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.002179 2.662
R-HSA-5619507 Activation of HOX genes during differentiation 0.002179 2.662
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.002301 2.638
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.002938 2.532
R-HSA-8953897 Cellular responses to stimuli 0.002702 2.568
R-HSA-2262752 Cellular responses to stress 0.003002 2.523
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.002848 2.546
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.002930 2.533
R-HSA-201681 TCF dependent signaling in response to WNT 0.002590 2.587
R-HSA-9609690 HCMV Early Events 0.003377 2.471
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.003377 2.471
R-HSA-5693538 Homology Directed Repair 0.003456 2.461
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.003941 2.404
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.004030 2.395
R-HSA-1474165 Reproduction 0.004927 2.307
R-HSA-418990 Adherens junctions interactions 0.005171 2.286
R-HSA-69278 Cell Cycle, Mitotic 0.005994 2.222
R-HSA-1640170 Cell Cycle 0.006738 2.171
R-HSA-3247509 Chromatin modifying enzymes 0.006762 2.170
R-HSA-8939211 ESR-mediated signaling 0.007094 2.149
R-HSA-5693532 DNA Double-Strand Break Repair 0.008501 2.071
R-HSA-4839726 Chromatin organization 0.008540 2.069
R-HSA-9609646 HCMV Infection 0.008669 2.062
R-HSA-421270 Cell-cell junction organization 0.008799 2.056
R-HSA-9673013 Diseases of Telomere Maintenance 0.009272 2.033
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.009272 2.033
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.009272 2.033
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.009272 2.033
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.009272 2.033
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.012348 1.908
R-HSA-5689880 Ub-specific processing proteases 0.012565 1.901
R-HSA-446728 Cell junction organization 0.012853 1.891
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.019727 1.705
R-HSA-3371511 HSF1 activation 0.017392 1.760
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.016036 1.795
R-HSA-389948 Co-inhibition by PD-1 0.019378 1.713
R-HSA-2559583 Cellular Senescence 0.014154 1.849
R-HSA-1538133 G0 and Early G1 0.013787 1.861
R-HSA-195721 Signaling by WNT 0.016566 1.781
R-HSA-1500931 Cell-Cell communication 0.020469 1.689
R-HSA-3371568 Attenuation phase 0.020533 1.688
R-HSA-212165 Epigenetic regulation of gene expression 0.022137 1.655
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.024763 1.606
R-HSA-8878171 Transcriptional regulation by RUNX1 0.028119 1.551
R-HSA-3371571 HSF1-dependent transactivation 0.031224 1.506
R-HSA-168316 Assembly of Viral Components at the Budding Site 0.032084 1.494
R-HSA-445355 Smooth Muscle Contraction 0.033179 1.479
R-HSA-9006931 Signaling by Nuclear Receptors 0.033366 1.477
R-HSA-157118 Signaling by NOTCH 0.033444 1.476
R-HSA-1483101 Synthesis of PS 0.036583 1.437
R-HSA-68689 CDC6 association with the ORC:origin complex 0.036583 1.437
R-HSA-191859 snRNP Assembly 0.039324 1.405
R-HSA-194441 Metabolism of non-coding RNA 0.039324 1.405
R-HSA-5688426 Deubiquitination 0.039765 1.401
R-HSA-68886 M Phase 0.040111 1.397
R-HSA-388841 Regulation of T cell activation by CD28 family 0.040209 1.396
R-HSA-983189 Kinesins 0.040387 1.394
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.041062 1.387
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.041502 1.382
R-HSA-9707616 Heme signaling 0.042546 1.371
R-HSA-8953854 Metabolism of RNA 0.045548 1.342
R-HSA-9610379 HCMV Late Events 0.048658 1.313
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.050430 1.297
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.052772 1.278
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.055153 1.258
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.062341 1.205
R-HSA-75205 Dissolution of Fibrin Clot 0.063151 1.200
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.066316 1.178
R-HSA-3000484 Scavenging by Class F Receptors 0.071846 1.144
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.071846 1.144
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.154526 0.811
R-HSA-68962 Activation of the pre-replicative complex 0.154526 0.811
R-HSA-156842 Eukaryotic Translation Elongation 0.082244 1.085
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.150571 0.822
R-HSA-156711 Polo-like kinase mediated events 0.101654 0.993
R-HSA-113510 E2F mediated regulation of DNA replication 0.105834 0.975
R-HSA-3928663 EPHA-mediated growth cone collapse 0.142604 0.846
R-HSA-8876725 Protein methylation 0.084738 1.072
R-HSA-9613829 Chaperone Mediated Autophagy 0.101654 0.993
R-HSA-9836573 Mitochondrial RNA degradation 0.130516 0.884
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.089196 1.050
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.109995 0.959
R-HSA-166208 mTORC1-mediated signalling 0.122365 0.912
R-HSA-9937008 Mitochondrial mRNA modification 0.126450 0.898
R-HSA-70635 Urea cycle 0.138594 0.858
R-HSA-73894 DNA Repair 0.101584 0.993
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.154526 0.811
R-HSA-8856688 Golgi-to-ER retrograde transport 0.151598 0.819
R-HSA-9734767 Developmental Cell Lineages 0.145651 0.837
R-HSA-400685 Sema4D in semaphorin signaling 0.134564 0.871
R-HSA-9909396 Circadian clock 0.151598 0.819
R-HSA-1280218 Adaptive Immune System 0.122940 0.910
R-HSA-168268 Virus Assembly and Release 0.088996 1.051
R-HSA-2132295 MHC class II antigen presentation 0.134067 0.873
R-HSA-9824446 Viral Infection Pathways 0.085330 1.069
R-HSA-9730414 MITF-M-regulated melanocyte development 0.095287 1.021
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.106547 0.972
R-HSA-9700206 Signaling by ALK in cancer 0.106547 0.972
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.158464 0.800
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.158464 0.800
R-HSA-9675126 Diseases of mitotic cell cycle 0.162383 0.789
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.163329 0.787
R-HSA-381119 Unfolded Protein Response (UPR) 0.164620 0.784
R-HSA-1855170 IPs transport between nucleus and cytosol 0.166285 0.779
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.166285 0.779
R-HSA-176187 Activation of ATR in response to replication stress 0.166285 0.779
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.170168 0.769
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.170168 0.769
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.170168 0.769
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 0.174034 0.759
R-HSA-180746 Nuclear import of Rev protein 0.174034 0.759
R-HSA-901042 Calnexin/calreticulin cycle 0.174034 0.759
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.174034 0.759
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.174034 0.759
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.177882 0.750
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.177882 0.750
R-HSA-9856651 MITF-M-dependent gene expression 0.184505 0.734
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.185525 0.732
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.187854 0.726
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.189320 0.723
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.193097 0.714
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.193097 0.714
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.196858 0.706
R-HSA-177243 Interactions of Rev with host cellular proteins 0.196858 0.706
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.196858 0.706
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.200601 0.698
R-HSA-1266738 Developmental Biology 0.200934 0.697
R-HSA-3000480 Scavenging by Class A Receptors 0.204326 0.690
R-HSA-379716 Cytosolic tRNA aminoacylation 0.208035 0.682
R-HSA-165159 MTOR signalling 0.208035 0.682
R-HSA-8854214 TBC/RABGAPs 0.211727 0.674
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.219059 0.659
R-HSA-168256 Immune System 0.219434 0.659
R-HSA-72306 tRNA processing 0.220043 0.657
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.222700 0.652
R-HSA-5620924 Intraflagellar transport 0.229931 0.638
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.233522 0.632
R-HSA-168255 Influenza Infection 0.235464 0.628
R-HSA-72187 mRNA 3'-end processing 0.244196 0.612
R-HSA-68949 Orc1 removal from chromatin 0.244196 0.612
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.250948 0.600
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.258200 0.588
R-HSA-2980766 Nuclear Envelope Breakdown 0.261660 0.582
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.271642 0.566
R-HSA-379724 tRNA Aminoacylation 0.271947 0.566
R-HSA-5663205 Infectious disease 0.272649 0.564
R-HSA-168325 Viral Messenger RNA Synthesis 0.275345 0.560
R-HSA-73856 RNA Polymerase II Transcription Termination 0.275345 0.560
R-HSA-6784531 tRNA processing in the nucleus 0.278727 0.555
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.278727 0.555
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.282093 0.550
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.282093 0.550
R-HSA-373755 Semaphorin interactions 0.282093 0.550
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.292099 0.534
R-HSA-397014 Muscle contraction 0.294050 0.532
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.298693 0.525
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.298693 0.525
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.311700 0.506
R-HSA-69052 Switching of origins to a post-replicative state 0.314914 0.502
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.314914 0.502
R-HSA-1169408 ISG15 antiviral mechanism 0.321298 0.493
R-HSA-72312 rRNA processing 0.328337 0.484
R-HSA-9659379 Sensory processing of sound 0.333891 0.476
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.333891 0.476
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.340101 0.468
R-HSA-9707564 Cytoprotection by HMOX1 0.346254 0.461
R-HSA-72766 Translation 0.349609 0.456
R-HSA-449147 Signaling by Interleukins 0.354739 0.450
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.355377 0.449
R-HSA-141424 Amplification of signal from the kinetochores 0.355377 0.449
R-HSA-390466 Chaperonin-mediated protein folding 0.361389 0.442
R-HSA-156902 Peptide chain elongation 0.364374 0.438
R-HSA-1236974 ER-Phagosome pathway 0.367346 0.435
R-HSA-391251 Protein folding 0.379095 0.421
R-HSA-2682334 EPH-Ephrin signaling 0.379095 0.421
R-HSA-6798695 Neutrophil degranulation 0.385228 0.414
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.393480 0.405
R-HSA-9614085 FOXO-mediated transcription 0.401952 0.396
R-HSA-69618 Mitotic Spindle Checkpoint 0.404750 0.393
R-HSA-70171 Glycolysis 0.404750 0.393
R-HSA-1483255 PI Metabolism 0.410308 0.387
R-HSA-9860931 Response of endothelial cells to shear stress 0.415814 0.381
R-HSA-9833110 RSV-host interactions 0.418548 0.378
R-HSA-9692914 SARS-CoV-1-host interactions 0.423979 0.373
R-HSA-69239 Synthesis of DNA 0.426675 0.370
R-HSA-1236975 Antigen processing-Cross presentation 0.429359 0.367
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.429359 0.367
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.432031 0.364
R-HSA-1483257 Phospholipid metabolism 0.432669 0.364
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.439971 0.357
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.439971 0.357
R-HSA-1483249 Inositol phosphate metabolism 0.439971 0.357
R-HSA-9855142 Cellular responses to mechanical stimuli 0.445204 0.351
R-HSA-70326 Glucose metabolism 0.458076 0.339
R-HSA-9007101 Rab regulation of trafficking 0.458076 0.339
R-HSA-1592230 Mitochondrial biogenesis 0.458076 0.339
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.468161 0.330
R-HSA-1852241 Organelle biogenesis and maintenance 0.471764 0.326
R-HSA-162909 Host Interactions of HIV factors 0.475604 0.323
R-HSA-69206 G1/S Transition 0.480508 0.318
R-HSA-9843745 Adipogenesis 0.497319 0.303
R-HSA-9679506 SARS-CoV Infections 0.505196 0.297
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.513593 0.289
R-HSA-109582 Hemostasis 0.520064 0.284
R-HSA-9664407 Parasite infection 0.520407 0.284
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.520407 0.284
R-HSA-9664417 Leishmania phagocytosis 0.520407 0.284
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.522658 0.282
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.527128 0.278
R-HSA-162599 Late Phase of HIV Life Cycle 0.527128 0.278
R-HSA-69242 S Phase 0.540291 0.267
R-HSA-5653656 Vesicle-mediated transport 0.543533 0.265
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.544597 0.264
R-HSA-9679191 Potential therapeutics for SARS 0.544597 0.264
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.548864 0.261
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.553092 0.257
R-HSA-73857 RNA Polymerase II Transcription 0.553144 0.257
R-HSA-1989781 PPARA activates gene expression 0.555191 0.256
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.555191 0.256
R-HSA-9612973 Autophagy 0.557280 0.254
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.559360 0.252
R-HSA-162587 HIV Life Cycle 0.559360 0.252
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.564221 0.249
R-HSA-2467813 Separation of Sister Chromatids 0.573650 0.241
R-HSA-2408522 Selenoamino acid metabolism 0.573650 0.241
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.579634 0.237
R-HSA-5619102 SLC transporter disorders 0.579634 0.237
R-HSA-1280215 Cytokine Signaling in Immune system 0.583554 0.234
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.587483 0.231
R-HSA-74160 Gene expression (Transcription) 0.589936 0.229
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.595187 0.225
R-HSA-9678108 SARS-CoV-1 Infection 0.597091 0.224
R-HSA-199991 Membrane Trafficking 0.607365 0.217
R-HSA-212436 Generic Transcription Pathway 0.607395 0.217
R-HSA-69275 G2/M Transition 0.617459 0.209
R-HSA-453274 Mitotic G2-G2/M phases 0.621052 0.207
R-HSA-5617833 Cilium Assembly 0.624611 0.204
R-HSA-68877 Mitotic Prometaphase 0.629888 0.201
R-HSA-72163 mRNA Splicing - Major Pathway 0.631631 0.200
R-HSA-376176 Signaling by ROBO receptors 0.646956 0.189
R-HSA-1483206 Glycerophospholipid biosynthesis 0.646956 0.189
R-HSA-72172 mRNA Splicing 0.650275 0.187
R-HSA-68882 Mitotic Anaphase 0.669553 0.174
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.671111 0.173
R-HSA-597592 Post-translational protein modification 0.677624 0.169
R-HSA-162906 HIV Infection 0.686301 0.163
R-HSA-9705683 SARS-CoV-2-host interactions 0.687781 0.163
R-HSA-1643685 Disease 0.697790 0.156
R-HSA-392499 Metabolism of proteins 0.712476 0.147
R-HSA-5619115 Disorders of transmembrane transporters 0.714634 0.146
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.717166 0.144
R-HSA-9711123 Cellular response to chemical stress 0.741667 0.130
R-HSA-422475 Axon guidance 0.745029 0.128
R-HSA-211945 Phase I - Functionalization of compounds 0.753636 0.123
R-HSA-9658195 Leishmania infection 0.757118 0.121
R-HSA-9824443 Parasitic Infection Pathways 0.757118 0.121
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.758268 0.120
R-HSA-9675108 Nervous system development 0.776178 0.110
R-HSA-162582 Signal Transduction 0.783655 0.106
R-HSA-8957322 Metabolism of steroids 0.802012 0.096
R-HSA-71291 Metabolism of amino acids and derivatives 0.803293 0.095
R-HSA-9694516 SARS-CoV-2 Infection 0.824237 0.084
R-HSA-913531 Interferon Signaling 0.851273 0.070
R-HSA-446203 Asparagine N-linked glycosylation 0.876584 0.057
R-HSA-168249 Innate Immune System 0.883520 0.054
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.894643 0.048
R-HSA-211859 Biological oxidations 0.924034 0.034
R-HSA-556833 Metabolism of lipids 0.976030 0.011
R-HSA-9709957 Sensory Perception 0.997759 0.001
R-HSA-1430728 Metabolism 0.999531 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.801 0.137 2 0.840
MOSMOS 0.790 0.144 1 0.762
KISKIS 0.787 0.091 1 0.652
DSTYKDSTYK 0.786 0.063 2 0.835
IKKBIKKB 0.780 0.013 -2 0.599
CLK3CLK3 0.780 0.061 1 0.698
GRK6GRK6 0.779 0.203 1 0.669
CAMK2GCAMK2G 0.779 0.042 2 0.777
GCN2GCN2 0.778 -0.075 2 0.769
PRPKPRPK 0.778 -0.106 -1 0.738
TBK1TBK1 0.778 -0.024 1 0.689
CAMK1BCAMK1B 0.778 0.021 -3 0.698
MTORMTOR 0.778 -0.038 1 0.727
RAF1RAF1 0.778 -0.047 1 0.733
GRK7GRK7 0.778 0.247 1 0.601
PIM3PIM3 0.777 0.029 -3 0.687
GRK1GRK1 0.777 0.129 -2 0.637
CDC7CDC7 0.777 -0.017 1 0.695
PKN3PKN3 0.776 0.032 -3 0.653
BMPR2BMPR2 0.775 -0.050 -2 0.744
TGFBR2TGFBR2 0.774 0.017 -2 0.745
IKKAIKKA 0.774 0.091 -2 0.578
NLKNLK 0.774 -0.013 1 0.754
IKKEIKKE 0.774 -0.038 1 0.683
ULK2ULK2 0.774 -0.098 2 0.785
GRK4GRK4 0.774 0.074 -2 0.677
NEK6NEK6 0.773 -0.017 -2 0.731
GRK5GRK5 0.773 0.049 -3 0.747
PDHK4PDHK4 0.773 -0.183 1 0.760
FAM20CFAM20C 0.772 0.098 2 0.566
TGFBR1TGFBR1 0.772 0.148 -2 0.731
PDHK1PDHK1 0.772 -0.119 1 0.768
NEK7NEK7 0.771 -0.066 -3 0.651
RSK2RSK2 0.771 0.040 -3 0.622
ATRATR 0.771 -0.027 1 0.720
MST4MST4 0.771 0.017 2 0.816
PIM1PIM1 0.771 0.057 -3 0.639
PLK1PLK1 0.771 0.086 -2 0.719
MLK1MLK1 0.770 -0.022 2 0.809
ALK4ALK4 0.770 0.121 -2 0.753
CK2A2CK2A2 0.770 0.381 1 0.628
PKCDPKCD 0.770 0.040 2 0.807
BMPR1BBMPR1B 0.769 0.131 1 0.588
CDKL1CDKL1 0.769 -0.028 -3 0.652
NDR2NDR2 0.769 -0.007 -3 0.684
BCKDKBCKDK 0.768 -0.023 -1 0.775
ERK5ERK5 0.768 -0.026 1 0.702
NIKNIK 0.768 -0.067 -3 0.707
CAMLCKCAMLCK 0.767 -0.039 -2 0.703
ANKRD3ANKRD3 0.766 -0.067 1 0.759
PKACGPKACG 0.766 0.053 -2 0.698
RIPK3RIPK3 0.766 -0.111 3 0.595
ACVR2AACVR2A 0.766 0.121 -2 0.733
SRPK1SRPK1 0.766 0.004 -3 0.613
PLK3PLK3 0.765 0.107 2 0.738
P90RSKP90RSK 0.765 -0.005 -3 0.624
ACVR2BACVR2B 0.764 0.114 -2 0.741
PKN2PKN2 0.764 -0.014 -3 0.656
WNK1WNK1 0.764 -0.075 -2 0.685
NDR1NDR1 0.763 -0.038 -3 0.671
HUNKHUNK 0.763 -0.103 2 0.790
ULK1ULK1 0.763 -0.114 -3 0.642
ALK2ALK2 0.763 0.125 -2 0.744
ATMATM 0.762 0.002 1 0.650
IRE2IRE2 0.762 -0.022 2 0.789
SKMLCKSKMLCK 0.762 -0.060 -2 0.680
RSK3RSK3 0.761 -0.013 -3 0.611
CDKL5CDKL5 0.761 -0.043 -3 0.640
LATS1LATS1 0.761 0.043 -3 0.701
P70S6KBP70S6KB 0.761 -0.003 -3 0.631
DAPK2DAPK2 0.760 -0.078 -3 0.690
ICKICK 0.760 -0.039 -3 0.676
CK2A1CK2A1 0.760 0.347 1 0.606
SRPK2SRPK2 0.760 0.006 -3 0.546
DLKDLK 0.759 -0.091 1 0.708
MLK4MLK4 0.759 0.013 2 0.729
TLK2TLK2 0.759 0.031 1 0.694
NEK9NEK9 0.759 -0.136 2 0.818
BMPR1ABMPR1A 0.758 0.131 1 0.578
PKRPKR 0.758 -0.032 1 0.735
MASTLMASTL 0.758 -0.202 -2 0.641
AMPKA1AMPKA1 0.758 -0.051 -3 0.670
TTBK2TTBK2 0.758 -0.054 2 0.710
IRE1IRE1 0.758 -0.086 1 0.691
PRKXPRKX 0.758 0.094 -3 0.543
WNK3WNK3 0.757 -0.173 1 0.737
MLK3MLK3 0.757 -0.030 2 0.759
CAMK2BCAMK2B 0.757 0.025 2 0.720
SRPK3SRPK3 0.757 -0.007 -3 0.593
YSK4YSK4 0.757 -0.049 1 0.692
NIM1NIM1 0.757 -0.080 3 0.619
NUAK2NUAK2 0.756 -0.093 -3 0.666
MARK4MARK4 0.756 -0.100 4 0.726
RSK4RSK4 0.756 0.034 -3 0.606
CDK5CDK5 0.756 0.027 1 0.640
CHAK2CHAK2 0.756 -0.130 -1 0.684
JNK3JNK3 0.755 0.055 1 0.612
CAMK4CAMK4 0.755 -0.042 -3 0.642
PLK4PLK4 0.755 -0.009 2 0.649
PRKD1PRKD1 0.755 -0.059 -3 0.636
PKACBPKACB 0.755 0.042 -2 0.631
CAMK2DCAMK2D 0.755 -0.086 -3 0.639
PKCAPKCA 0.755 0.006 2 0.762
CK1ECK1E 0.755 0.100 -3 0.605
PRKD2PRKD2 0.754 -0.019 -3 0.592
PKG2PKG2 0.754 0.056 -2 0.666
PAK1PAK1 0.754 -0.038 -2 0.625
PKCGPKCG 0.754 -0.001 2 0.769
AURCAURC 0.754 -0.000 -2 0.594
HIPK4HIPK4 0.754 -0.071 1 0.713
RIPK1RIPK1 0.754 -0.181 1 0.709
TSSK2TSSK2 0.753 -0.038 -5 0.680
JNK2JNK2 0.753 0.049 1 0.585
MEK1MEK1 0.753 -0.078 2 0.777
CDK8CDK8 0.753 -0.018 1 0.634
CDK1CDK1 0.753 0.023 1 0.568
SGK3SGK3 0.753 0.042 -3 0.589
BRAFBRAF 0.753 -0.008 -4 0.820
PKCBPKCB 0.752 -0.000 2 0.752
MLK2MLK2 0.752 -0.156 2 0.783
AURAAURA 0.752 -0.006 -2 0.524
HRIHRI 0.752 -0.082 -2 0.743
AKT2AKT2 0.752 0.017 -3 0.543
LATS2LATS2 0.752 -0.065 -5 0.653
MEKK3MEKK3 0.751 -0.042 1 0.699
VRK2VRK2 0.751 -0.184 1 0.770
PLK2PLK2 0.751 0.114 -3 0.741
TSSK1TSSK1 0.751 -0.032 -3 0.684
PKCHPKCH 0.751 -0.018 2 0.756
GRK2GRK2 0.751 -0.015 -2 0.586
PERKPERK 0.750 -0.063 -2 0.741
DNAPKDNAPK 0.750 -0.021 1 0.664
AURBAURB 0.750 -0.014 -2 0.583
MSK2MSK2 0.750 -0.046 -3 0.589
AMPKA2AMPKA2 0.750 -0.067 -3 0.642
ZAKZAK 0.750 -0.054 1 0.705
MAPKAPK3MAPKAPK3 0.750 -0.071 -3 0.589
CAMK2ACAMK2A 0.750 -0.002 2 0.732
MEKK2MEKK2 0.750 -0.020 2 0.776
CK1DCK1D 0.750 0.103 -3 0.563
MEKK1MEKK1 0.749 -0.074 1 0.738
CLK4CLK4 0.749 -0.019 -3 0.622
MAPKAPK2MAPKAPK2 0.749 -0.014 -3 0.578
CK1G1CK1G1 0.749 0.075 -3 0.620
CK1A2CK1A2 0.748 0.108 -3 0.562
PAK3PAK3 0.748 -0.092 -2 0.628
TLK1TLK1 0.748 -0.017 -2 0.712
PIM2PIM2 0.748 -0.001 -3 0.590
PHKG1PHKG1 0.747 -0.077 -3 0.644
P38GP38G 0.747 0.037 1 0.512
PAK2PAK2 0.747 -0.071 -2 0.614
P38AP38A 0.747 -0.004 1 0.651
NEK2NEK2 0.747 -0.089 2 0.794
PKACAPKACA 0.746 0.041 -2 0.609
MELKMELK 0.746 -0.089 -3 0.617
PRKD3PRKD3 0.746 -0.036 -3 0.574
GRK3GRK3 0.746 0.028 -2 0.556
CDK19CDK19 0.745 -0.025 1 0.603
CDK18CDK18 0.745 0.007 1 0.570
MSK1MSK1 0.745 -0.022 -3 0.588
NUAK1NUAK1 0.745 -0.096 -3 0.620
MYLK4MYLK4 0.745 -0.050 -2 0.645
CDK7CDK7 0.745 -0.038 1 0.635
DYRK2DYRK2 0.744 -0.028 1 0.645
GSK3AGSK3A 0.744 0.038 4 0.449
CDK13CDK13 0.744 -0.024 1 0.610
SIKSIK 0.744 -0.071 -3 0.591
QIKQIK 0.744 -0.134 -3 0.636
CLK1CLK1 0.744 -0.022 -3 0.591
AKT1AKT1 0.744 0.008 -3 0.546
PKCZPKCZ 0.744 -0.087 2 0.784
MNK1MNK1 0.744 -0.053 -2 0.687
CDK2CDK2 0.743 -0.029 1 0.630
PINK1PINK1 0.743 -0.120 1 0.756
CHK1CHK1 0.743 -0.076 -3 0.652
P38BP38B 0.743 0.007 1 0.584
CDK3CDK3 0.743 0.024 1 0.532
ERK2ERK2 0.743 -0.010 1 0.613
ERK1ERK1 0.743 -0.000 1 0.590
MNK2MNK2 0.742 -0.083 -2 0.658
TAO3TAO3 0.742 -0.036 1 0.703
QSKQSK 0.741 -0.089 4 0.694
PAK6PAK6 0.741 -0.052 -2 0.572
GSK3BGSK3B 0.741 -0.004 4 0.439
CDK17CDK17 0.741 0.003 1 0.517
MST3MST3 0.741 -0.027 2 0.807
DCAMKL1DCAMKL1 0.741 -0.051 -3 0.612
CAMK1GCAMK1G 0.740 -0.058 -3 0.588
MEK5MEK5 0.740 -0.193 2 0.785
PRP4PRP4 0.740 -0.039 -3 0.608
DCAMKL2DCAMKL2 0.740 -0.038 -3 0.632
DRAK1DRAK1 0.740 -0.090 1 0.603
P38DP38D 0.740 0.038 1 0.561
GAKGAK 0.740 0.051 1 0.758
WNK4WNK4 0.740 -0.124 -2 0.678
NEK8NEK8 0.739 -0.079 2 0.822
CLK2CLK2 0.739 0.011 -3 0.612
CHAK1CHAK1 0.739 -0.170 2 0.756
PKCTPKCT 0.738 -0.038 2 0.758
SMMLCKSMMLCK 0.738 -0.054 -3 0.645
SMG1SMG1 0.738 -0.118 1 0.691
CDK14CDK14 0.738 0.005 1 0.609
SGK1SGK1 0.738 0.047 -3 0.484
HIPK1HIPK1 0.737 -0.023 1 0.666
CDK12CDK12 0.737 -0.025 1 0.587
MARK2MARK2 0.737 -0.089 4 0.615
IRAK4IRAK4 0.737 -0.124 1 0.701
MST2MST2 0.736 -0.012 1 0.699
CDK16CDK16 0.736 0.023 1 0.533
MPSK1MPSK1 0.736 -0.055 1 0.742
NEK5NEK5 0.736 -0.148 1 0.734
TTBK1TTBK1 0.736 -0.074 2 0.653
SNRKSNRK 0.736 -0.171 2 0.703
HIPK2HIPK2 0.736 -0.010 1 0.581
PHKG2PHKG2 0.735 -0.070 -3 0.616
DYRK1ADYRK1A 0.735 -0.036 1 0.682
JNK1JNK1 0.734 0.030 1 0.564
TAO2TAO2 0.734 -0.078 2 0.844
PKCEPKCE 0.733 -0.002 2 0.761
MARK3MARK3 0.733 -0.097 4 0.656
AKT3AKT3 0.733 0.016 -3 0.492
BRSK2BRSK2 0.733 -0.143 -3 0.619
BRSK1BRSK1 0.733 -0.109 -3 0.610
CDK10CDK10 0.733 0.018 1 0.597
PASKPASK 0.733 -0.056 -3 0.696
CAMK1DCAMK1D 0.733 -0.024 -3 0.524
P70S6KP70S6K 0.733 -0.047 -3 0.543
CDK9CDK9 0.733 -0.049 1 0.617
EEF2KEEF2K 0.732 -0.022 3 0.659
TAK1TAK1 0.731 -0.035 1 0.730
CAMKK1CAMKK1 0.731 -0.131 -2 0.633
IRAK1IRAK1 0.731 -0.173 -1 0.635
ERK7ERK7 0.730 0.015 2 0.577
PDK1PDK1 0.730 -0.082 1 0.724
PKCIPKCI 0.730 -0.070 2 0.763
MRCKBMRCKB 0.729 0.012 -3 0.573
MARK1MARK1 0.729 -0.122 4 0.676
SSTKSSTK 0.729 -0.045 4 0.694
NEK11NEK11 0.728 -0.156 1 0.712
MINKMINK 0.728 -0.071 1 0.713
TTKTTK 0.728 0.056 -2 0.720
GCKGCK 0.728 -0.071 1 0.698
HGKHGK 0.727 -0.084 3 0.650
HIPK3HIPK3 0.727 -0.066 1 0.671
DYRK1BDYRK1B 0.727 -0.021 1 0.595
PKN1PKN1 0.727 -0.034 -3 0.546
MAPKAPK5MAPKAPK5 0.727 -0.157 -3 0.529
TNIKTNIK 0.727 -0.051 3 0.645
DYRK3DYRK3 0.727 -0.038 1 0.671
DYRK4DYRK4 0.727 -0.019 1 0.588
DAPK3DAPK3 0.727 -0.043 -3 0.635
MRCKAMRCKA 0.726 -0.005 -3 0.590
ROCK2ROCK2 0.726 0.013 -3 0.621
MST1MST1 0.725 -0.061 1 0.697
MAP3K15MAP3K15 0.725 -0.117 1 0.702
CDK6CDK6 0.725 -0.004 1 0.605
RIPK2RIPK2 0.724 -0.160 1 0.679
CAMKK2CAMKK2 0.723 -0.157 -2 0.618
PAK5PAK5 0.723 -0.082 -2 0.507
CAMK1ACAMK1A 0.723 -0.028 -3 0.510
NEK4NEK4 0.722 -0.173 1 0.716
LKB1LKB1 0.722 -0.158 -3 0.613
DMPK1DMPK1 0.722 0.020 -3 0.602
DAPK1DAPK1 0.721 -0.047 -3 0.622
SBKSBK 0.721 -0.003 -3 0.442
CHK2CHK2 0.721 -0.056 -3 0.490
PKG1PKG1 0.721 0.027 -2 0.626
LOKLOK 0.721 -0.078 -2 0.652
YSK1YSK1 0.720 -0.079 2 0.794
PAK4PAK4 0.720 -0.078 -2 0.495
HPK1HPK1 0.720 -0.088 1 0.685
LRRK2LRRK2 0.720 -0.178 2 0.834
CDK4CDK4 0.719 -0.017 1 0.581
KHS2KHS2 0.719 -0.032 1 0.709
VRK1VRK1 0.719 -0.173 2 0.835
MEKK6MEKK6 0.718 -0.184 1 0.705
MAKMAK 0.718 -0.022 -2 0.514
OSR1OSR1 0.717 -0.033 2 0.751
KHS1KHS1 0.717 -0.070 1 0.704
NEK1NEK1 0.717 -0.178 1 0.714
SLKSLK 0.716 -0.086 -2 0.594
PBKPBK 0.716 -0.014 1 0.723
MEK2MEK2 0.715 -0.190 2 0.758
BUB1BUB1 0.714 -0.019 -5 0.623
ALPHAK3ALPHAK3 0.713 0.009 -1 0.659
STK33STK33 0.713 -0.154 2 0.642
YANK3YANK3 0.713 -0.003 2 0.425
ROCK1ROCK1 0.712 -0.011 -3 0.586
CK1ACK1A 0.711 0.058 -3 0.505
MOKMOK 0.710 -0.051 1 0.658
CRIKCRIK 0.709 -0.014 -3 0.554
NEK3NEK3 0.708 -0.184 1 0.711
MYO3AMYO3A 0.705 -0.083 1 0.698
BIKEBIKE 0.704 0.006 1 0.687
HASPINHASPIN 0.704 -0.072 -1 0.545
CK1G3CK1G3 0.703 0.072 -3 0.469
PDHK3_TYRPDHK3_TYR 0.703 0.108 4 0.789
MYO3BMYO3B 0.702 -0.104 2 0.804
ASK1ASK1 0.702 -0.152 1 0.693
TAO1TAO1 0.700 -0.117 1 0.670
BMPR2_TYRBMPR2_TYR 0.699 0.055 -1 0.789
PDHK4_TYRPDHK4_TYR 0.698 0.098 2 0.812
MAP2K6_TYRMAP2K6_TYR 0.696 0.055 -1 0.776
TESK1_TYRTESK1_TYR 0.695 -0.060 3 0.694
STLK3STLK3 0.694 -0.121 1 0.668
PDHK1_TYRPDHK1_TYR 0.694 0.042 -1 0.787
MAP2K4_TYRMAP2K4_TYR 0.694 -0.028 -1 0.762
PINK1_TYRPINK1_TYR 0.693 -0.062 1 0.728
MAP2K7_TYRMAP2K7_TYR 0.693 -0.070 2 0.822
PKMYT1_TYRPKMYT1_TYR 0.693 -0.112 3 0.680
RETRET 0.689 -0.054 1 0.713
YES1YES1 0.689 0.023 -1 0.733
CK1G2CK1G2 0.689 0.044 -3 0.545
EPHA6EPHA6 0.689 -0.007 -1 0.793
TYK2TYK2 0.688 -0.109 1 0.714
FGRFGR 0.687 -0.027 1 0.720
CSF1RCSF1R 0.687 -0.063 3 0.621
AAK1AAK1 0.687 0.025 1 0.609
EPHB4EPHB4 0.686 -0.033 -1 0.769
JAK2JAK2 0.685 -0.109 1 0.718
MST1RMST1R 0.684 -0.126 3 0.619
LCKLCK 0.684 0.025 -1 0.745
ROS1ROS1 0.684 -0.102 3 0.597
BLKBLK 0.684 0.046 -1 0.752
INSRRINSRR 0.684 -0.039 3 0.594
LIMK2_TYRLIMK2_TYR 0.683 -0.117 -3 0.699
JAK3JAK3 0.683 -0.068 1 0.696
HCKHCK 0.683 -0.030 -1 0.734
TXKTXK 0.682 0.032 1 0.681
FYNFYN 0.682 0.068 -1 0.733
PDGFRBPDGFRB 0.682 -0.073 3 0.623
TYRO3TYRO3 0.682 -0.124 3 0.618
DDR1DDR1 0.682 -0.103 4 0.724
FLT3FLT3 0.681 -0.055 3 0.617
YANK2YANK2 0.681 -0.023 2 0.444
LIMK1_TYRLIMK1_TYR 0.681 -0.164 2 0.837
FERFER 0.681 -0.067 1 0.707
KDRKDR 0.681 -0.054 3 0.590
KITKIT 0.680 -0.075 3 0.631
ABL2ABL2 0.680 -0.064 -1 0.708
FGFR2FGFR2 0.680 -0.078 3 0.627
EPHB2EPHB2 0.678 -0.025 -1 0.759
EPHA4EPHA4 0.677 -0.043 2 0.740
FLT1FLT1 0.677 -0.019 -1 0.774
EPHB1EPHB1 0.677 -0.060 1 0.668
TNNI3K_TYRTNNI3K_TYR 0.677 -0.047 1 0.745
FGFR1FGFR1 0.677 -0.094 3 0.606
LYNLYN 0.676 -0.006 3 0.598
EPHB3EPHB3 0.676 -0.057 -1 0.772
ABL1ABL1 0.674 -0.085 -1 0.698
JAK1JAK1 0.674 -0.095 1 0.687
ITKITK 0.674 -0.079 -1 0.697
FLT4FLT4 0.674 -0.073 3 0.610
SRMSSRMS 0.673 -0.088 1 0.668
METMET 0.672 -0.078 3 0.596
ERBB2ERBB2 0.672 -0.078 1 0.650
SRCSRC 0.672 0.006 -1 0.725
NTRK1NTRK1 0.670 -0.111 -1 0.744
TNK2TNK2 0.670 -0.138 3 0.580
FGFR3FGFR3 0.670 -0.078 3 0.605
PDGFRAPDGFRA 0.670 -0.170 3 0.623
NTRK2NTRK2 0.670 -0.103 3 0.593
AXLAXL 0.669 -0.113 3 0.602
DDR2DDR2 0.669 -0.041 3 0.586
EGFREGFR 0.669 -0.011 1 0.558
TNK1TNK1 0.668 -0.128 3 0.610
LTKLTK 0.668 -0.110 3 0.594
ALKALK 0.668 -0.122 3 0.573
WEE1_TYRWEE1_TYR 0.668 -0.092 -1 0.625
INSRINSR 0.668 -0.095 3 0.572
NEK10_TYRNEK10_TYR 0.668 -0.120 1 0.633
EPHA3EPHA3 0.668 -0.075 2 0.732
TEKTEK 0.667 -0.157 3 0.590
FRKFRK 0.667 -0.077 -1 0.740
EPHA7EPHA7 0.667 -0.073 2 0.758
BTKBTK 0.667 -0.154 -1 0.644
PTK6PTK6 0.666 -0.129 -1 0.635
MERTKMERTK 0.666 -0.109 3 0.604
TECTEC 0.666 -0.089 -1 0.615
BMXBMX 0.665 -0.087 -1 0.605
PTK2PTK2 0.664 0.030 -1 0.747
EPHA8EPHA8 0.664 -0.045 -1 0.770
NTRK3NTRK3 0.664 -0.106 -1 0.712
EPHA5EPHA5 0.663 -0.050 2 0.728
SYKSYK 0.663 0.027 -1 0.733
FGFR4FGFR4 0.663 -0.047 -1 0.689
PTK2BPTK2B 0.660 -0.082 -1 0.671
MATKMATK 0.659 -0.102 -1 0.643
IGF1RIGF1R 0.658 -0.079 3 0.542
EPHA1EPHA1 0.657 -0.160 3 0.576
CSKCSK 0.657 -0.109 2 0.763
ERBB4ERBB4 0.654 -0.027 1 0.534
MUSKMUSK 0.653 -0.107 1 0.543
EPHA2EPHA2 0.650 -0.081 -1 0.726
ZAP70ZAP70 0.635 -0.045 -1 0.643
FESFES 0.630 -0.147 -1 0.596