Motif 754 (n=65)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A4UGR9 | XIRP2 | S2717 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
A6NKT7 | RGPD3 | S1608 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
A6NMY6 | ANXA2P2 | S127 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
H0YC42 | None | S171 | ochoa | Tumor protein D52 | None |
O00193 | SMAP | S82 | ochoa | Small acidic protein | None |
O00418 | EEF2K | S243 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
O14715 | RGPD8 | S1607 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
O15061 | SYNM | S699 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
O15234 | CASC3 | T143 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
O75717 | WDHD1 | S888 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
P07355 | ANXA2 | S127 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
P07814 | EPRS1 | S330 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
P0DJD0 | RGPD1 | S1592 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
P0DJD1 | RGPD2 | S1600 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
P10244 | MYBL2 | S282 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
P16435 | POR | S63 | ochoa | NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) | This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP-Rule:MF_03212}. |
P27816 | MAP4 | S71 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
P30414 | NKTR | S1077 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
P35749 | MYH11 | T1368 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
P46100 | ATRX | S651 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P46821 | MAP1B | S1421 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P48651 | PTDSS1 | S454 | ochoa | Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535). {ECO:0000269|PubMed:19014349, ECO:0000269|PubMed:24241535}. |
P49792 | RANBP2 | S2583 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P50851 | LRBA | S1231 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
Q12912 | IRAG2 | S182 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
Q12912 | IRAG2 | S447 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
Q13416 | ORC2 | S255 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
Q15311 | RALBP1 | S93 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
Q2M2Z5 | KIZ | S618 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
Q53EL6 | PDCD4 | S49 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
Q5SW79 | CEP170 | S1079 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5T200 | ZC3H13 | S1017 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
Q5VZK9 | CARMIL1 | S1068 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
Q76FK4 | NOL8 | S268 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
Q7Z3J3 | RGPD4 | S1608 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q7Z6E9 | RBBP6 | S1341 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
Q8NDI1 | EHBP1 | S730 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
Q96EB6 | SIRT1 | S590 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
Q96RS0 | TGS1 | S158 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
Q99666 | RGPD5 | S1607 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
Q9H0A0 | NAT10 | S984 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
Q9H1H9 | KIF13A | S1734 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
Q9H582 | ZNF644 | S828 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
Q9HAU0 | PLEKHA5 | S126 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
Q9HCE3 | ZNF532 | S1256 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
Q9HCE5 | METTL14 | S54 | ochoa | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27281194, PubMed:27373337, PubMed:29348140). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}. |
Q9UEE5 | STK17A | S348 | ochoa | Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) | Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. |
Q9UKX2 | MYH2 | S1239 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9ULU4 | ZMYND8 | S460 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
Q9UN81 | L1RE1 | S145 | ochoa | LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}. |
Q9Y3P9 | RABGAP1 | S37 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
Q9Y4W2 | LAS1L | S238 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
Q9Y520 | PRRC2C | S376 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
Q9BR76 | CORO1B | S391 | Sugiyama | Coronin-1B (Coronin-2) | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}. |
Q9ULV4 | CORO1C | S389 | Sugiyama | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
O75391 | SPAG7 | S57 | Sugiyama | Sperm-associated antigen 7 | None |
Q02790 | FKBP4 | T278 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
P68104 | EEF1A1 | S53 | SIGNOR | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
Q05639 | EEF1A2 | S53 | SIGNOR | Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}. |
Q07866 | KLC1 | S445 | Sugiyama | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
P33778 | H2BC3 | S33 | EPSD | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
P62807 | H2BC4 | S33 | ELM | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
P27797 | CALR | S53 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
P42704 | LRPPRC | S1027 | Sugiyama | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
Q9HBH9 | MKNK2 | S338 | Sugiyama | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.000003 | 5.511 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.000002 | 5.649 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.000001 | 5.903 |
R-HSA-171306 | Packaging Of Telomere Ends | 0.000019 | 4.719 |
R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.000019 | 4.719 |
R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.000013 | 4.880 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.000016 | 4.803 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.000018 | 4.742 |
R-HSA-5334118 | DNA methylation | 0.000024 | 4.620 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.000044 | 4.354 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.000039 | 4.408 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.000033 | 4.482 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.000035 | 4.459 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.000044 | 4.354 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.000053 | 4.275 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.000061 | 4.213 |
R-HSA-110331 | Cleavage of the damaged purine | 0.000058 | 4.236 |
R-HSA-73927 | Depurination | 0.000063 | 4.199 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.000081 | 4.091 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.000075 | 4.126 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.000081 | 4.091 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.000095 | 4.023 |
R-HSA-73928 | Depyrimidination | 0.000095 | 4.023 |
R-HSA-9710421 | Defective pyroptosis | 0.000102 | 3.991 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.000127 | 3.896 |
R-HSA-774815 | Nucleosome assembly | 0.000118 | 3.927 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.000118 | 3.927 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.000127 | 3.895 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.000146 | 3.836 |
R-HSA-1221632 | Meiotic synapsis | 0.000202 | 3.695 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.000190 | 3.722 |
R-HSA-912446 | Meiotic recombination | 0.000178 | 3.750 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.000202 | 3.695 |
R-HSA-3214847 | HATs acetylate histones | 0.000173 | 3.763 |
R-HSA-157579 | Telomere Maintenance | 0.000159 | 3.800 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.000190 | 3.722 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.000215 | 3.668 |
R-HSA-3214815 | HDACs deacetylate histones | 0.000228 | 3.642 |
R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.000264 | 3.579 |
R-HSA-211000 | Gene Silencing by RNA | 0.000248 | 3.606 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.000267 | 3.573 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.000288 | 3.541 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.000304 | 3.517 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.000339 | 3.469 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.000339 | 3.469 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.000462 | 3.336 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.000439 | 3.357 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.000418 | 3.379 |
R-HSA-3371556 | Cellular response to heat stress | 0.000439 | 3.357 |
R-HSA-68875 | Mitotic Prophase | 0.000425 | 3.372 |
R-HSA-73886 | Chromosome Maintenance | 0.000439 | 3.357 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.000397 | 3.401 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.000509 | 3.294 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.000517 | 3.286 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.000517 | 3.286 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.000517 | 3.286 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.000533 | 3.273 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.000533 | 3.273 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.000613 | 3.213 |
R-HSA-69481 | G2/M Checkpoints | 0.000551 | 3.259 |
R-HSA-8852135 | Protein ubiquitination | 0.000641 | 3.193 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.000670 | 3.174 |
R-HSA-9020591 | Interleukin-12 signaling | 0.000670 | 3.174 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.000731 | 3.136 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.000770 | 3.114 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.000830 | 3.081 |
R-HSA-977225 | Amyloid fiber formation | 0.000830 | 3.081 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.000844 | 3.074 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.000865 | 3.063 |
R-HSA-1500620 | Meiosis | 0.000976 | 3.011 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.000938 | 3.028 |
R-HSA-447115 | Interleukin-12 family signaling | 0.001096 | 2.960 |
R-HSA-9645723 | Diseases of programmed cell death | 0.001138 | 2.944 |
R-HSA-73884 | Base Excision Repair | 0.001227 | 2.911 |
R-HSA-69306 | DNA Replication | 0.001258 | 2.900 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.001273 | 2.895 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.001291 | 2.889 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.001928 | 2.715 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.001983 | 2.703 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.001983 | 2.703 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.002082 | 2.681 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.002082 | 2.681 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.002179 | 2.662 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.002179 | 2.662 |
R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.002301 | 2.638 |
R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.002938 | 2.532 |
R-HSA-8953897 | Cellular responses to stimuli | 0.002702 | 2.568 |
R-HSA-2262752 | Cellular responses to stress | 0.003002 | 2.523 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.002848 | 2.546 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.002930 | 2.533 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.002590 | 2.587 |
R-HSA-9609690 | HCMV Early Events | 0.003377 | 2.471 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.003377 | 2.471 |
R-HSA-5693538 | Homology Directed Repair | 0.003456 | 2.461 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.003941 | 2.404 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.004030 | 2.395 |
R-HSA-1474165 | Reproduction | 0.004927 | 2.307 |
R-HSA-418990 | Adherens junctions interactions | 0.005171 | 2.286 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.005994 | 2.222 |
R-HSA-1640170 | Cell Cycle | 0.006738 | 2.171 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.006762 | 2.170 |
R-HSA-8939211 | ESR-mediated signaling | 0.007094 | 2.149 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.008501 | 2.071 |
R-HSA-4839726 | Chromatin organization | 0.008540 | 2.069 |
R-HSA-9609646 | HCMV Infection | 0.008669 | 2.062 |
R-HSA-421270 | Cell-cell junction organization | 0.008799 | 2.056 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.009272 | 2.033 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.009272 | 2.033 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.009272 | 2.033 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.009272 | 2.033 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.009272 | 2.033 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.012348 | 1.908 |
R-HSA-5689880 | Ub-specific processing proteases | 0.012565 | 1.901 |
R-HSA-446728 | Cell junction organization | 0.012853 | 1.891 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.019727 | 1.705 |
R-HSA-3371511 | HSF1 activation | 0.017392 | 1.760 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.016036 | 1.795 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.019378 | 1.713 |
R-HSA-2559583 | Cellular Senescence | 0.014154 | 1.849 |
R-HSA-1538133 | G0 and Early G1 | 0.013787 | 1.861 |
R-HSA-195721 | Signaling by WNT | 0.016566 | 1.781 |
R-HSA-1500931 | Cell-Cell communication | 0.020469 | 1.689 |
R-HSA-3371568 | Attenuation phase | 0.020533 | 1.688 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.022137 | 1.655 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.024763 | 1.606 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.028119 | 1.551 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.031224 | 1.506 |
R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.032084 | 1.494 |
R-HSA-445355 | Smooth Muscle Contraction | 0.033179 | 1.479 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.033366 | 1.477 |
R-HSA-157118 | Signaling by NOTCH | 0.033444 | 1.476 |
R-HSA-1483101 | Synthesis of PS | 0.036583 | 1.437 |
R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.036583 | 1.437 |
R-HSA-191859 | snRNP Assembly | 0.039324 | 1.405 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.039324 | 1.405 |
R-HSA-5688426 | Deubiquitination | 0.039765 | 1.401 |
R-HSA-68886 | M Phase | 0.040111 | 1.397 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.040209 | 1.396 |
R-HSA-983189 | Kinesins | 0.040387 | 1.394 |
R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.041062 | 1.387 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.041502 | 1.382 |
R-HSA-9707616 | Heme signaling | 0.042546 | 1.371 |
R-HSA-8953854 | Metabolism of RNA | 0.045548 | 1.342 |
R-HSA-9610379 | HCMV Late Events | 0.048658 | 1.313 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.050430 | 1.297 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.052772 | 1.278 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.055153 | 1.258 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.062341 | 1.205 |
R-HSA-75205 | Dissolution of Fibrin Clot | 0.063151 | 1.200 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.066316 | 1.178 |
R-HSA-3000484 | Scavenging by Class F Receptors | 0.071846 | 1.144 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.071846 | 1.144 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.154526 | 0.811 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.154526 | 0.811 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.082244 | 1.085 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.150571 | 0.822 |
R-HSA-156711 | Polo-like kinase mediated events | 0.101654 | 0.993 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.105834 | 0.975 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.142604 | 0.846 |
R-HSA-8876725 | Protein methylation | 0.084738 | 1.072 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.101654 | 0.993 |
R-HSA-9836573 | Mitochondrial RNA degradation | 0.130516 | 0.884 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.089196 | 1.050 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.109995 | 0.959 |
R-HSA-166208 | mTORC1-mediated signalling | 0.122365 | 0.912 |
R-HSA-9937008 | Mitochondrial mRNA modification | 0.126450 | 0.898 |
R-HSA-70635 | Urea cycle | 0.138594 | 0.858 |
R-HSA-73894 | DNA Repair | 0.101584 | 0.993 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.154526 | 0.811 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.151598 | 0.819 |
R-HSA-9734767 | Developmental Cell Lineages | 0.145651 | 0.837 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.134564 | 0.871 |
R-HSA-9909396 | Circadian clock | 0.151598 | 0.819 |
R-HSA-1280218 | Adaptive Immune System | 0.122940 | 0.910 |
R-HSA-168268 | Virus Assembly and Release | 0.088996 | 1.051 |
R-HSA-2132295 | MHC class II antigen presentation | 0.134067 | 0.873 |
R-HSA-9824446 | Viral Infection Pathways | 0.085330 | 1.069 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.095287 | 1.021 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.106547 | 0.972 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.106547 | 0.972 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.158464 | 0.800 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.158464 | 0.800 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.162383 | 0.789 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.163329 | 0.787 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.164620 | 0.784 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.166285 | 0.779 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.166285 | 0.779 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.166285 | 0.779 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.170168 | 0.769 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.170168 | 0.769 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.170168 | 0.769 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.174034 | 0.759 |
R-HSA-180746 | Nuclear import of Rev protein | 0.174034 | 0.759 |
R-HSA-901042 | Calnexin/calreticulin cycle | 0.174034 | 0.759 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.174034 | 0.759 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.174034 | 0.759 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.177882 | 0.750 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.177882 | 0.750 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.184505 | 0.734 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.185525 | 0.732 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.187854 | 0.726 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.189320 | 0.723 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.193097 | 0.714 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.193097 | 0.714 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.196858 | 0.706 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.196858 | 0.706 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.196858 | 0.706 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.200601 | 0.698 |
R-HSA-1266738 | Developmental Biology | 0.200934 | 0.697 |
R-HSA-3000480 | Scavenging by Class A Receptors | 0.204326 | 0.690 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.208035 | 0.682 |
R-HSA-165159 | MTOR signalling | 0.208035 | 0.682 |
R-HSA-8854214 | TBC/RABGAPs | 0.211727 | 0.674 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.219059 | 0.659 |
R-HSA-168256 | Immune System | 0.219434 | 0.659 |
R-HSA-72306 | tRNA processing | 0.220043 | 0.657 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.222700 | 0.652 |
R-HSA-5620924 | Intraflagellar transport | 0.229931 | 0.638 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.233522 | 0.632 |
R-HSA-168255 | Influenza Infection | 0.235464 | 0.628 |
R-HSA-72187 | mRNA 3'-end processing | 0.244196 | 0.612 |
R-HSA-68949 | Orc1 removal from chromatin | 0.244196 | 0.612 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.250948 | 0.600 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.258200 | 0.588 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.261660 | 0.582 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.271642 | 0.566 |
R-HSA-379724 | tRNA Aminoacylation | 0.271947 | 0.566 |
R-HSA-5663205 | Infectious disease | 0.272649 | 0.564 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.275345 | 0.560 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.275345 | 0.560 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.278727 | 0.555 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.278727 | 0.555 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.282093 | 0.550 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.282093 | 0.550 |
R-HSA-373755 | Semaphorin interactions | 0.282093 | 0.550 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.292099 | 0.534 |
R-HSA-397014 | Muscle contraction | 0.294050 | 0.532 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.298693 | 0.525 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.298693 | 0.525 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.311700 | 0.506 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.314914 | 0.502 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.314914 | 0.502 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.321298 | 0.493 |
R-HSA-72312 | rRNA processing | 0.328337 | 0.484 |
R-HSA-9659379 | Sensory processing of sound | 0.333891 | 0.476 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.333891 | 0.476 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.340101 | 0.468 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.346254 | 0.461 |
R-HSA-72766 | Translation | 0.349609 | 0.456 |
R-HSA-449147 | Signaling by Interleukins | 0.354739 | 0.450 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.355377 | 0.449 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.355377 | 0.449 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.361389 | 0.442 |
R-HSA-156902 | Peptide chain elongation | 0.364374 | 0.438 |
R-HSA-1236974 | ER-Phagosome pathway | 0.367346 | 0.435 |
R-HSA-391251 | Protein folding | 0.379095 | 0.421 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.379095 | 0.421 |
R-HSA-6798695 | Neutrophil degranulation | 0.385228 | 0.414 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.393480 | 0.405 |
R-HSA-9614085 | FOXO-mediated transcription | 0.401952 | 0.396 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.404750 | 0.393 |
R-HSA-70171 | Glycolysis | 0.404750 | 0.393 |
R-HSA-1483255 | PI Metabolism | 0.410308 | 0.387 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.415814 | 0.381 |
R-HSA-9833110 | RSV-host interactions | 0.418548 | 0.378 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.423979 | 0.373 |
R-HSA-69239 | Synthesis of DNA | 0.426675 | 0.370 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.429359 | 0.367 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.429359 | 0.367 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.432031 | 0.364 |
R-HSA-1483257 | Phospholipid metabolism | 0.432669 | 0.364 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.439971 | 0.357 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.439971 | 0.357 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.439971 | 0.357 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.445204 | 0.351 |
R-HSA-70326 | Glucose metabolism | 0.458076 | 0.339 |
R-HSA-9007101 | Rab regulation of trafficking | 0.458076 | 0.339 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.458076 | 0.339 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.468161 | 0.330 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.471764 | 0.326 |
R-HSA-162909 | Host Interactions of HIV factors | 0.475604 | 0.323 |
R-HSA-69206 | G1/S Transition | 0.480508 | 0.318 |
R-HSA-9843745 | Adipogenesis | 0.497319 | 0.303 |
R-HSA-9679506 | SARS-CoV Infections | 0.505196 | 0.297 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.513593 | 0.289 |
R-HSA-109582 | Hemostasis | 0.520064 | 0.284 |
R-HSA-9664407 | Parasite infection | 0.520407 | 0.284 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.520407 | 0.284 |
R-HSA-9664417 | Leishmania phagocytosis | 0.520407 | 0.284 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.522658 | 0.282 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.527128 | 0.278 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.527128 | 0.278 |
R-HSA-69242 | S Phase | 0.540291 | 0.267 |
R-HSA-5653656 | Vesicle-mediated transport | 0.543533 | 0.265 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.544597 | 0.264 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.544597 | 0.264 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.548864 | 0.261 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.553092 | 0.257 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.553144 | 0.257 |
R-HSA-1989781 | PPARA activates gene expression | 0.555191 | 0.256 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.555191 | 0.256 |
R-HSA-9612973 | Autophagy | 0.557280 | 0.254 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.559360 | 0.252 |
R-HSA-162587 | HIV Life Cycle | 0.559360 | 0.252 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.564221 | 0.249 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.573650 | 0.241 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.573650 | 0.241 |
R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.579634 | 0.237 |
R-HSA-5619102 | SLC transporter disorders | 0.579634 | 0.237 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.583554 | 0.234 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.587483 | 0.231 |
R-HSA-74160 | Gene expression (Transcription) | 0.589936 | 0.229 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.595187 | 0.225 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.597091 | 0.224 |
R-HSA-199991 | Membrane Trafficking | 0.607365 | 0.217 |
R-HSA-212436 | Generic Transcription Pathway | 0.607395 | 0.217 |
R-HSA-69275 | G2/M Transition | 0.617459 | 0.209 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.621052 | 0.207 |
R-HSA-5617833 | Cilium Assembly | 0.624611 | 0.204 |
R-HSA-68877 | Mitotic Prometaphase | 0.629888 | 0.201 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.631631 | 0.200 |
R-HSA-376176 | Signaling by ROBO receptors | 0.646956 | 0.189 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.646956 | 0.189 |
R-HSA-72172 | mRNA Splicing | 0.650275 | 0.187 |
R-HSA-68882 | Mitotic Anaphase | 0.669553 | 0.174 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.671111 | 0.173 |
R-HSA-597592 | Post-translational protein modification | 0.677624 | 0.169 |
R-HSA-162906 | HIV Infection | 0.686301 | 0.163 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.687781 | 0.163 |
R-HSA-1643685 | Disease | 0.697790 | 0.156 |
R-HSA-392499 | Metabolism of proteins | 0.712476 | 0.147 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.714634 | 0.146 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.717166 | 0.144 |
R-HSA-9711123 | Cellular response to chemical stress | 0.741667 | 0.130 |
R-HSA-422475 | Axon guidance | 0.745029 | 0.128 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.753636 | 0.123 |
R-HSA-9658195 | Leishmania infection | 0.757118 | 0.121 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.757118 | 0.121 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.758268 | 0.120 |
R-HSA-9675108 | Nervous system development | 0.776178 | 0.110 |
R-HSA-162582 | Signal Transduction | 0.783655 | 0.106 |
R-HSA-8957322 | Metabolism of steroids | 0.802012 | 0.096 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.803293 | 0.095 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.824237 | 0.084 |
R-HSA-913531 | Interferon Signaling | 0.851273 | 0.070 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.876584 | 0.057 |
R-HSA-168249 | Innate Immune System | 0.883520 | 0.054 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.894643 | 0.048 |
R-HSA-211859 | Biological oxidations | 0.924034 | 0.034 |
R-HSA-556833 | Metabolism of lipids | 0.976030 | 0.011 |
R-HSA-9709957 | Sensory Perception | 0.997759 | 0.001 |
R-HSA-1430728 | Metabolism | 0.999531 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.801 | 0.137 | 2 | 0.840 |
MOS |
0.790 | 0.144 | 1 | 0.762 |
KIS |
0.787 | 0.091 | 1 | 0.652 |
DSTYK |
0.786 | 0.063 | 2 | 0.835 |
IKKB |
0.780 | 0.013 | -2 | 0.599 |
CLK3 |
0.780 | 0.061 | 1 | 0.698 |
GRK6 |
0.779 | 0.203 | 1 | 0.669 |
CAMK2G |
0.779 | 0.042 | 2 | 0.777 |
GCN2 |
0.778 | -0.075 | 2 | 0.769 |
PRPK |
0.778 | -0.106 | -1 | 0.738 |
TBK1 |
0.778 | -0.024 | 1 | 0.689 |
CAMK1B |
0.778 | 0.021 | -3 | 0.698 |
MTOR |
0.778 | -0.038 | 1 | 0.727 |
RAF1 |
0.778 | -0.047 | 1 | 0.733 |
GRK7 |
0.778 | 0.247 | 1 | 0.601 |
PIM3 |
0.777 | 0.029 | -3 | 0.687 |
GRK1 |
0.777 | 0.129 | -2 | 0.637 |
CDC7 |
0.777 | -0.017 | 1 | 0.695 |
PKN3 |
0.776 | 0.032 | -3 | 0.653 |
BMPR2 |
0.775 | -0.050 | -2 | 0.744 |
TGFBR2 |
0.774 | 0.017 | -2 | 0.745 |
IKKA |
0.774 | 0.091 | -2 | 0.578 |
NLK |
0.774 | -0.013 | 1 | 0.754 |
IKKE |
0.774 | -0.038 | 1 | 0.683 |
ULK2 |
0.774 | -0.098 | 2 | 0.785 |
GRK4 |
0.774 | 0.074 | -2 | 0.677 |
NEK6 |
0.773 | -0.017 | -2 | 0.731 |
GRK5 |
0.773 | 0.049 | -3 | 0.747 |
PDHK4 |
0.773 | -0.183 | 1 | 0.760 |
FAM20C |
0.772 | 0.098 | 2 | 0.566 |
TGFBR1 |
0.772 | 0.148 | -2 | 0.731 |
PDHK1 |
0.772 | -0.119 | 1 | 0.768 |
NEK7 |
0.771 | -0.066 | -3 | 0.651 |
RSK2 |
0.771 | 0.040 | -3 | 0.622 |
ATR |
0.771 | -0.027 | 1 | 0.720 |
MST4 |
0.771 | 0.017 | 2 | 0.816 |
PIM1 |
0.771 | 0.057 | -3 | 0.639 |
PLK1 |
0.771 | 0.086 | -2 | 0.719 |
MLK1 |
0.770 | -0.022 | 2 | 0.809 |
ALK4 |
0.770 | 0.121 | -2 | 0.753 |
CK2A2 |
0.770 | 0.381 | 1 | 0.628 |
PKCD |
0.770 | 0.040 | 2 | 0.807 |
BMPR1B |
0.769 | 0.131 | 1 | 0.588 |
CDKL1 |
0.769 | -0.028 | -3 | 0.652 |
NDR2 |
0.769 | -0.007 | -3 | 0.684 |
BCKDK |
0.768 | -0.023 | -1 | 0.775 |
ERK5 |
0.768 | -0.026 | 1 | 0.702 |
NIK |
0.768 | -0.067 | -3 | 0.707 |
CAMLCK |
0.767 | -0.039 | -2 | 0.703 |
ANKRD3 |
0.766 | -0.067 | 1 | 0.759 |
PKACG |
0.766 | 0.053 | -2 | 0.698 |
RIPK3 |
0.766 | -0.111 | 3 | 0.595 |
ACVR2A |
0.766 | 0.121 | -2 | 0.733 |
SRPK1 |
0.766 | 0.004 | -3 | 0.613 |
PLK3 |
0.765 | 0.107 | 2 | 0.738 |
P90RSK |
0.765 | -0.005 | -3 | 0.624 |
ACVR2B |
0.764 | 0.114 | -2 | 0.741 |
PKN2 |
0.764 | -0.014 | -3 | 0.656 |
WNK1 |
0.764 | -0.075 | -2 | 0.685 |
NDR1 |
0.763 | -0.038 | -3 | 0.671 |
HUNK |
0.763 | -0.103 | 2 | 0.790 |
ULK1 |
0.763 | -0.114 | -3 | 0.642 |
ALK2 |
0.763 | 0.125 | -2 | 0.744 |
ATM |
0.762 | 0.002 | 1 | 0.650 |
IRE2 |
0.762 | -0.022 | 2 | 0.789 |
SKMLCK |
0.762 | -0.060 | -2 | 0.680 |
RSK3 |
0.761 | -0.013 | -3 | 0.611 |
CDKL5 |
0.761 | -0.043 | -3 | 0.640 |
LATS1 |
0.761 | 0.043 | -3 | 0.701 |
P70S6KB |
0.761 | -0.003 | -3 | 0.631 |
DAPK2 |
0.760 | -0.078 | -3 | 0.690 |
ICK |
0.760 | -0.039 | -3 | 0.676 |
CK2A1 |
0.760 | 0.347 | 1 | 0.606 |
SRPK2 |
0.760 | 0.006 | -3 | 0.546 |
DLK |
0.759 | -0.091 | 1 | 0.708 |
MLK4 |
0.759 | 0.013 | 2 | 0.729 |
TLK2 |
0.759 | 0.031 | 1 | 0.694 |
NEK9 |
0.759 | -0.136 | 2 | 0.818 |
BMPR1A |
0.758 | 0.131 | 1 | 0.578 |
PKR |
0.758 | -0.032 | 1 | 0.735 |
MASTL |
0.758 | -0.202 | -2 | 0.641 |
AMPKA1 |
0.758 | -0.051 | -3 | 0.670 |
TTBK2 |
0.758 | -0.054 | 2 | 0.710 |
IRE1 |
0.758 | -0.086 | 1 | 0.691 |
PRKX |
0.758 | 0.094 | -3 | 0.543 |
WNK3 |
0.757 | -0.173 | 1 | 0.737 |
MLK3 |
0.757 | -0.030 | 2 | 0.759 |
CAMK2B |
0.757 | 0.025 | 2 | 0.720 |
SRPK3 |
0.757 | -0.007 | -3 | 0.593 |
YSK4 |
0.757 | -0.049 | 1 | 0.692 |
NIM1 |
0.757 | -0.080 | 3 | 0.619 |
NUAK2 |
0.756 | -0.093 | -3 | 0.666 |
MARK4 |
0.756 | -0.100 | 4 | 0.726 |
RSK4 |
0.756 | 0.034 | -3 | 0.606 |
CDK5 |
0.756 | 0.027 | 1 | 0.640 |
CHAK2 |
0.756 | -0.130 | -1 | 0.684 |
JNK3 |
0.755 | 0.055 | 1 | 0.612 |
CAMK4 |
0.755 | -0.042 | -3 | 0.642 |
PLK4 |
0.755 | -0.009 | 2 | 0.649 |
PRKD1 |
0.755 | -0.059 | -3 | 0.636 |
PKACB |
0.755 | 0.042 | -2 | 0.631 |
CAMK2D |
0.755 | -0.086 | -3 | 0.639 |
PKCA |
0.755 | 0.006 | 2 | 0.762 |
CK1E |
0.755 | 0.100 | -3 | 0.605 |
PRKD2 |
0.754 | -0.019 | -3 | 0.592 |
PKG2 |
0.754 | 0.056 | -2 | 0.666 |
PAK1 |
0.754 | -0.038 | -2 | 0.625 |
PKCG |
0.754 | -0.001 | 2 | 0.769 |
AURC |
0.754 | -0.000 | -2 | 0.594 |
HIPK4 |
0.754 | -0.071 | 1 | 0.713 |
RIPK1 |
0.754 | -0.181 | 1 | 0.709 |
TSSK2 |
0.753 | -0.038 | -5 | 0.680 |
JNK2 |
0.753 | 0.049 | 1 | 0.585 |
MEK1 |
0.753 | -0.078 | 2 | 0.777 |
CDK8 |
0.753 | -0.018 | 1 | 0.634 |
CDK1 |
0.753 | 0.023 | 1 | 0.568 |
SGK3 |
0.753 | 0.042 | -3 | 0.589 |
BRAF |
0.753 | -0.008 | -4 | 0.820 |
PKCB |
0.752 | -0.000 | 2 | 0.752 |
MLK2 |
0.752 | -0.156 | 2 | 0.783 |
AURA |
0.752 | -0.006 | -2 | 0.524 |
HRI |
0.752 | -0.082 | -2 | 0.743 |
AKT2 |
0.752 | 0.017 | -3 | 0.543 |
LATS2 |
0.752 | -0.065 | -5 | 0.653 |
MEKK3 |
0.751 | -0.042 | 1 | 0.699 |
VRK2 |
0.751 | -0.184 | 1 | 0.770 |
PLK2 |
0.751 | 0.114 | -3 | 0.741 |
TSSK1 |
0.751 | -0.032 | -3 | 0.684 |
PKCH |
0.751 | -0.018 | 2 | 0.756 |
GRK2 |
0.751 | -0.015 | -2 | 0.586 |
PERK |
0.750 | -0.063 | -2 | 0.741 |
DNAPK |
0.750 | -0.021 | 1 | 0.664 |
AURB |
0.750 | -0.014 | -2 | 0.583 |
MSK2 |
0.750 | -0.046 | -3 | 0.589 |
AMPKA2 |
0.750 | -0.067 | -3 | 0.642 |
ZAK |
0.750 | -0.054 | 1 | 0.705 |
MAPKAPK3 |
0.750 | -0.071 | -3 | 0.589 |
CAMK2A |
0.750 | -0.002 | 2 | 0.732 |
MEKK2 |
0.750 | -0.020 | 2 | 0.776 |
CK1D |
0.750 | 0.103 | -3 | 0.563 |
MEKK1 |
0.749 | -0.074 | 1 | 0.738 |
CLK4 |
0.749 | -0.019 | -3 | 0.622 |
MAPKAPK2 |
0.749 | -0.014 | -3 | 0.578 |
CK1G1 |
0.749 | 0.075 | -3 | 0.620 |
CK1A2 |
0.748 | 0.108 | -3 | 0.562 |
PAK3 |
0.748 | -0.092 | -2 | 0.628 |
TLK1 |
0.748 | -0.017 | -2 | 0.712 |
PIM2 |
0.748 | -0.001 | -3 | 0.590 |
PHKG1 |
0.747 | -0.077 | -3 | 0.644 |
P38G |
0.747 | 0.037 | 1 | 0.512 |
PAK2 |
0.747 | -0.071 | -2 | 0.614 |
P38A |
0.747 | -0.004 | 1 | 0.651 |
NEK2 |
0.747 | -0.089 | 2 | 0.794 |
PKACA |
0.746 | 0.041 | -2 | 0.609 |
MELK |
0.746 | -0.089 | -3 | 0.617 |
PRKD3 |
0.746 | -0.036 | -3 | 0.574 |
GRK3 |
0.746 | 0.028 | -2 | 0.556 |
CDK19 |
0.745 | -0.025 | 1 | 0.603 |
CDK18 |
0.745 | 0.007 | 1 | 0.570 |
MSK1 |
0.745 | -0.022 | -3 | 0.588 |
NUAK1 |
0.745 | -0.096 | -3 | 0.620 |
MYLK4 |
0.745 | -0.050 | -2 | 0.645 |
CDK7 |
0.745 | -0.038 | 1 | 0.635 |
DYRK2 |
0.744 | -0.028 | 1 | 0.645 |
GSK3A |
0.744 | 0.038 | 4 | 0.449 |
CDK13 |
0.744 | -0.024 | 1 | 0.610 |
SIK |
0.744 | -0.071 | -3 | 0.591 |
QIK |
0.744 | -0.134 | -3 | 0.636 |
CLK1 |
0.744 | -0.022 | -3 | 0.591 |
AKT1 |
0.744 | 0.008 | -3 | 0.546 |
PKCZ |
0.744 | -0.087 | 2 | 0.784 |
MNK1 |
0.744 | -0.053 | -2 | 0.687 |
CDK2 |
0.743 | -0.029 | 1 | 0.630 |
PINK1 |
0.743 | -0.120 | 1 | 0.756 |
CHK1 |
0.743 | -0.076 | -3 | 0.652 |
P38B |
0.743 | 0.007 | 1 | 0.584 |
CDK3 |
0.743 | 0.024 | 1 | 0.532 |
ERK2 |
0.743 | -0.010 | 1 | 0.613 |
ERK1 |
0.743 | -0.000 | 1 | 0.590 |
MNK2 |
0.742 | -0.083 | -2 | 0.658 |
TAO3 |
0.742 | -0.036 | 1 | 0.703 |
QSK |
0.741 | -0.089 | 4 | 0.694 |
PAK6 |
0.741 | -0.052 | -2 | 0.572 |
GSK3B |
0.741 | -0.004 | 4 | 0.439 |
CDK17 |
0.741 | 0.003 | 1 | 0.517 |
MST3 |
0.741 | -0.027 | 2 | 0.807 |
DCAMKL1 |
0.741 | -0.051 | -3 | 0.612 |
CAMK1G |
0.740 | -0.058 | -3 | 0.588 |
MEK5 |
0.740 | -0.193 | 2 | 0.785 |
PRP4 |
0.740 | -0.039 | -3 | 0.608 |
DCAMKL2 |
0.740 | -0.038 | -3 | 0.632 |
DRAK1 |
0.740 | -0.090 | 1 | 0.603 |
P38D |
0.740 | 0.038 | 1 | 0.561 |
GAK |
0.740 | 0.051 | 1 | 0.758 |
WNK4 |
0.740 | -0.124 | -2 | 0.678 |
NEK8 |
0.739 | -0.079 | 2 | 0.822 |
CLK2 |
0.739 | 0.011 | -3 | 0.612 |
CHAK1 |
0.739 | -0.170 | 2 | 0.756 |
PKCT |
0.738 | -0.038 | 2 | 0.758 |
SMMLCK |
0.738 | -0.054 | -3 | 0.645 |
SMG1 |
0.738 | -0.118 | 1 | 0.691 |
CDK14 |
0.738 | 0.005 | 1 | 0.609 |
SGK1 |
0.738 | 0.047 | -3 | 0.484 |
HIPK1 |
0.737 | -0.023 | 1 | 0.666 |
CDK12 |
0.737 | -0.025 | 1 | 0.587 |
MARK2 |
0.737 | -0.089 | 4 | 0.615 |
IRAK4 |
0.737 | -0.124 | 1 | 0.701 |
MST2 |
0.736 | -0.012 | 1 | 0.699 |
CDK16 |
0.736 | 0.023 | 1 | 0.533 |
MPSK1 |
0.736 | -0.055 | 1 | 0.742 |
NEK5 |
0.736 | -0.148 | 1 | 0.734 |
TTBK1 |
0.736 | -0.074 | 2 | 0.653 |
SNRK |
0.736 | -0.171 | 2 | 0.703 |
HIPK2 |
0.736 | -0.010 | 1 | 0.581 |
PHKG2 |
0.735 | -0.070 | -3 | 0.616 |
DYRK1A |
0.735 | -0.036 | 1 | 0.682 |
JNK1 |
0.734 | 0.030 | 1 | 0.564 |
TAO2 |
0.734 | -0.078 | 2 | 0.844 |
PKCE |
0.733 | -0.002 | 2 | 0.761 |
MARK3 |
0.733 | -0.097 | 4 | 0.656 |
AKT3 |
0.733 | 0.016 | -3 | 0.492 |
BRSK2 |
0.733 | -0.143 | -3 | 0.619 |
BRSK1 |
0.733 | -0.109 | -3 | 0.610 |
CDK10 |
0.733 | 0.018 | 1 | 0.597 |
PASK |
0.733 | -0.056 | -3 | 0.696 |
CAMK1D |
0.733 | -0.024 | -3 | 0.524 |
P70S6K |
0.733 | -0.047 | -3 | 0.543 |
CDK9 |
0.733 | -0.049 | 1 | 0.617 |
EEF2K |
0.732 | -0.022 | 3 | 0.659 |
TAK1 |
0.731 | -0.035 | 1 | 0.730 |
CAMKK1 |
0.731 | -0.131 | -2 | 0.633 |
IRAK1 |
0.731 | -0.173 | -1 | 0.635 |
ERK7 |
0.730 | 0.015 | 2 | 0.577 |
PDK1 |
0.730 | -0.082 | 1 | 0.724 |
PKCI |
0.730 | -0.070 | 2 | 0.763 |
MRCKB |
0.729 | 0.012 | -3 | 0.573 |
MARK1 |
0.729 | -0.122 | 4 | 0.676 |
SSTK |
0.729 | -0.045 | 4 | 0.694 |
NEK11 |
0.728 | -0.156 | 1 | 0.712 |
MINK |
0.728 | -0.071 | 1 | 0.713 |
TTK |
0.728 | 0.056 | -2 | 0.720 |
GCK |
0.728 | -0.071 | 1 | 0.698 |
HGK |
0.727 | -0.084 | 3 | 0.650 |
HIPK3 |
0.727 | -0.066 | 1 | 0.671 |
DYRK1B |
0.727 | -0.021 | 1 | 0.595 |
PKN1 |
0.727 | -0.034 | -3 | 0.546 |
MAPKAPK5 |
0.727 | -0.157 | -3 | 0.529 |
TNIK |
0.727 | -0.051 | 3 | 0.645 |
DYRK3 |
0.727 | -0.038 | 1 | 0.671 |
DYRK4 |
0.727 | -0.019 | 1 | 0.588 |
DAPK3 |
0.727 | -0.043 | -3 | 0.635 |
MRCKA |
0.726 | -0.005 | -3 | 0.590 |
ROCK2 |
0.726 | 0.013 | -3 | 0.621 |
MST1 |
0.725 | -0.061 | 1 | 0.697 |
MAP3K15 |
0.725 | -0.117 | 1 | 0.702 |
CDK6 |
0.725 | -0.004 | 1 | 0.605 |
RIPK2 |
0.724 | -0.160 | 1 | 0.679 |
CAMKK2 |
0.723 | -0.157 | -2 | 0.618 |
PAK5 |
0.723 | -0.082 | -2 | 0.507 |
CAMK1A |
0.723 | -0.028 | -3 | 0.510 |
NEK4 |
0.722 | -0.173 | 1 | 0.716 |
LKB1 |
0.722 | -0.158 | -3 | 0.613 |
DMPK1 |
0.722 | 0.020 | -3 | 0.602 |
DAPK1 |
0.721 | -0.047 | -3 | 0.622 |
SBK |
0.721 | -0.003 | -3 | 0.442 |
CHK2 |
0.721 | -0.056 | -3 | 0.490 |
PKG1 |
0.721 | 0.027 | -2 | 0.626 |
LOK |
0.721 | -0.078 | -2 | 0.652 |
YSK1 |
0.720 | -0.079 | 2 | 0.794 |
PAK4 |
0.720 | -0.078 | -2 | 0.495 |
HPK1 |
0.720 | -0.088 | 1 | 0.685 |
LRRK2 |
0.720 | -0.178 | 2 | 0.834 |
CDK4 |
0.719 | -0.017 | 1 | 0.581 |
KHS2 |
0.719 | -0.032 | 1 | 0.709 |
VRK1 |
0.719 | -0.173 | 2 | 0.835 |
MEKK6 |
0.718 | -0.184 | 1 | 0.705 |
MAK |
0.718 | -0.022 | -2 | 0.514 |
OSR1 |
0.717 | -0.033 | 2 | 0.751 |
KHS1 |
0.717 | -0.070 | 1 | 0.704 |
NEK1 |
0.717 | -0.178 | 1 | 0.714 |
SLK |
0.716 | -0.086 | -2 | 0.594 |
PBK |
0.716 | -0.014 | 1 | 0.723 |
MEK2 |
0.715 | -0.190 | 2 | 0.758 |
BUB1 |
0.714 | -0.019 | -5 | 0.623 |
ALPHAK3 |
0.713 | 0.009 | -1 | 0.659 |
STK33 |
0.713 | -0.154 | 2 | 0.642 |
YANK3 |
0.713 | -0.003 | 2 | 0.425 |
ROCK1 |
0.712 | -0.011 | -3 | 0.586 |
CK1A |
0.711 | 0.058 | -3 | 0.505 |
MOK |
0.710 | -0.051 | 1 | 0.658 |
CRIK |
0.709 | -0.014 | -3 | 0.554 |
NEK3 |
0.708 | -0.184 | 1 | 0.711 |
MYO3A |
0.705 | -0.083 | 1 | 0.698 |
BIKE |
0.704 | 0.006 | 1 | 0.687 |
HASPIN |
0.704 | -0.072 | -1 | 0.545 |
CK1G3 |
0.703 | 0.072 | -3 | 0.469 |
PDHK3_TYR |
0.703 | 0.108 | 4 | 0.789 |
MYO3B |
0.702 | -0.104 | 2 | 0.804 |
ASK1 |
0.702 | -0.152 | 1 | 0.693 |
TAO1 |
0.700 | -0.117 | 1 | 0.670 |
BMPR2_TYR |
0.699 | 0.055 | -1 | 0.789 |
PDHK4_TYR |
0.698 | 0.098 | 2 | 0.812 |
MAP2K6_TYR |
0.696 | 0.055 | -1 | 0.776 |
TESK1_TYR |
0.695 | -0.060 | 3 | 0.694 |
STLK3 |
0.694 | -0.121 | 1 | 0.668 |
PDHK1_TYR |
0.694 | 0.042 | -1 | 0.787 |
MAP2K4_TYR |
0.694 | -0.028 | -1 | 0.762 |
PINK1_TYR |
0.693 | -0.062 | 1 | 0.728 |
MAP2K7_TYR |
0.693 | -0.070 | 2 | 0.822 |
PKMYT1_TYR |
0.693 | -0.112 | 3 | 0.680 |
RET |
0.689 | -0.054 | 1 | 0.713 |
YES1 |
0.689 | 0.023 | -1 | 0.733 |
CK1G2 |
0.689 | 0.044 | -3 | 0.545 |
EPHA6 |
0.689 | -0.007 | -1 | 0.793 |
TYK2 |
0.688 | -0.109 | 1 | 0.714 |
FGR |
0.687 | -0.027 | 1 | 0.720 |
CSF1R |
0.687 | -0.063 | 3 | 0.621 |
AAK1 |
0.687 | 0.025 | 1 | 0.609 |
EPHB4 |
0.686 | -0.033 | -1 | 0.769 |
JAK2 |
0.685 | -0.109 | 1 | 0.718 |
MST1R |
0.684 | -0.126 | 3 | 0.619 |
LCK |
0.684 | 0.025 | -1 | 0.745 |
ROS1 |
0.684 | -0.102 | 3 | 0.597 |
BLK |
0.684 | 0.046 | -1 | 0.752 |
INSRR |
0.684 | -0.039 | 3 | 0.594 |
LIMK2_TYR |
0.683 | -0.117 | -3 | 0.699 |
JAK3 |
0.683 | -0.068 | 1 | 0.696 |
HCK |
0.683 | -0.030 | -1 | 0.734 |
TXK |
0.682 | 0.032 | 1 | 0.681 |
FYN |
0.682 | 0.068 | -1 | 0.733 |
PDGFRB |
0.682 | -0.073 | 3 | 0.623 |
TYRO3 |
0.682 | -0.124 | 3 | 0.618 |
DDR1 |
0.682 | -0.103 | 4 | 0.724 |
FLT3 |
0.681 | -0.055 | 3 | 0.617 |
YANK2 |
0.681 | -0.023 | 2 | 0.444 |
LIMK1_TYR |
0.681 | -0.164 | 2 | 0.837 |
FER |
0.681 | -0.067 | 1 | 0.707 |
KDR |
0.681 | -0.054 | 3 | 0.590 |
KIT |
0.680 | -0.075 | 3 | 0.631 |
ABL2 |
0.680 | -0.064 | -1 | 0.708 |
FGFR2 |
0.680 | -0.078 | 3 | 0.627 |
EPHB2 |
0.678 | -0.025 | -1 | 0.759 |
EPHA4 |
0.677 | -0.043 | 2 | 0.740 |
FLT1 |
0.677 | -0.019 | -1 | 0.774 |
EPHB1 |
0.677 | -0.060 | 1 | 0.668 |
TNNI3K_TYR |
0.677 | -0.047 | 1 | 0.745 |
FGFR1 |
0.677 | -0.094 | 3 | 0.606 |
LYN |
0.676 | -0.006 | 3 | 0.598 |
EPHB3 |
0.676 | -0.057 | -1 | 0.772 |
ABL1 |
0.674 | -0.085 | -1 | 0.698 |
JAK1 |
0.674 | -0.095 | 1 | 0.687 |
ITK |
0.674 | -0.079 | -1 | 0.697 |
FLT4 |
0.674 | -0.073 | 3 | 0.610 |
SRMS |
0.673 | -0.088 | 1 | 0.668 |
MET |
0.672 | -0.078 | 3 | 0.596 |
ERBB2 |
0.672 | -0.078 | 1 | 0.650 |
SRC |
0.672 | 0.006 | -1 | 0.725 |
NTRK1 |
0.670 | -0.111 | -1 | 0.744 |
TNK2 |
0.670 | -0.138 | 3 | 0.580 |
FGFR3 |
0.670 | -0.078 | 3 | 0.605 |
PDGFRA |
0.670 | -0.170 | 3 | 0.623 |
NTRK2 |
0.670 | -0.103 | 3 | 0.593 |
AXL |
0.669 | -0.113 | 3 | 0.602 |
DDR2 |
0.669 | -0.041 | 3 | 0.586 |
EGFR |
0.669 | -0.011 | 1 | 0.558 |
TNK1 |
0.668 | -0.128 | 3 | 0.610 |
LTK |
0.668 | -0.110 | 3 | 0.594 |
ALK |
0.668 | -0.122 | 3 | 0.573 |
WEE1_TYR |
0.668 | -0.092 | -1 | 0.625 |
INSR |
0.668 | -0.095 | 3 | 0.572 |
NEK10_TYR |
0.668 | -0.120 | 1 | 0.633 |
EPHA3 |
0.668 | -0.075 | 2 | 0.732 |
TEK |
0.667 | -0.157 | 3 | 0.590 |
FRK |
0.667 | -0.077 | -1 | 0.740 |
EPHA7 |
0.667 | -0.073 | 2 | 0.758 |
BTK |
0.667 | -0.154 | -1 | 0.644 |
PTK6 |
0.666 | -0.129 | -1 | 0.635 |
MERTK |
0.666 | -0.109 | 3 | 0.604 |
TEC |
0.666 | -0.089 | -1 | 0.615 |
BMX |
0.665 | -0.087 | -1 | 0.605 |
PTK2 |
0.664 | 0.030 | -1 | 0.747 |
EPHA8 |
0.664 | -0.045 | -1 | 0.770 |
NTRK3 |
0.664 | -0.106 | -1 | 0.712 |
EPHA5 |
0.663 | -0.050 | 2 | 0.728 |
SYK |
0.663 | 0.027 | -1 | 0.733 |
FGFR4 |
0.663 | -0.047 | -1 | 0.689 |
PTK2B |
0.660 | -0.082 | -1 | 0.671 |
MATK |
0.659 | -0.102 | -1 | 0.643 |
IGF1R |
0.658 | -0.079 | 3 | 0.542 |
EPHA1 |
0.657 | -0.160 | 3 | 0.576 |
CSK |
0.657 | -0.109 | 2 | 0.763 |
ERBB4 |
0.654 | -0.027 | 1 | 0.534 |
MUSK |
0.653 | -0.107 | 1 | 0.543 |
EPHA2 |
0.650 | -0.081 | -1 | 0.726 |
ZAP70 |
0.635 | -0.045 | -1 | 0.643 |
FES |
0.630 | -0.147 | -1 | 0.596 |