Motif 753 (n=166)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S1058 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A1L170 | C1orf226 | S196 | ochoa | Uncharacterized protein C1orf226 | None |
| A6NMY6 | ANXA2P2 | S26 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| E9PCH4 | None | S1256 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| H0YIS7 | RNASEK-C17orf49 | S187 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| O00192 | ARVCF | S267 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00541 | PES1 | S282 | ochoa | Pescadillo homolog | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}. |
| O00567 | NOP56 | S314 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14578 | CIT | S795 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O15015 | ZNF646 | S936 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O43290 | SART1 | S378 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O43581 | SYT7 | S113 | ochoa | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) | Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. |
| O43815 | STRN | S227 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60220 | TIMM8A | S57 | ochoa | Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. |
| O60333 | KIF1B | S1487 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60716 | CTNND1 | S899 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75110 | ATP9A | S629 | ochoa | Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A) | Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:27733620, PubMed:30213940, PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Required for the maintenance of neurite morphology and synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O70228, ECO:0000269|PubMed:27733620, ECO:0000269|PubMed:30213940, ECO:0000269|PubMed:30947313, ECO:0000269|PubMed:36604604}. |
| O75376 | NCOR1 | S766 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O76070 | SNCG | S73 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| O95197 | RTN3 | S591 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95235 | KIF20A | S632 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95239 | KIF4A | S801 | ochoa|psp | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| P05783 | KRT18 | S319 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06753 | TPM3 | S88 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07355 | ANXA2 | S26 | ochoa|psp | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07384 | CAPN1 | S290 | ochoa | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| P07814 | EPRS1 | S434 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P07951 | TPM2 | S87 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P08195 | SLC3A2 | S129 | ochoa | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P08559 | PDHA1 | S295 | ochoa|psp | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}. |
| P11387 | TOP1 | S506 | psp | DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter. {ECO:0000250|UniProtKB:Q13472, ECO:0000269|PubMed:14594810, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:22904072, ECO:0000269|PubMed:2833744}. |
| P14625 | HSP90B1 | S64 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P17661 | DES | S424 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P17677 | GAP43 | S153 | ochoa | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}. |
| P19338 | NCL | S496 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P29803 | PDHA2 | S293 | ochoa | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II) | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:16436377}. |
| P31629 | HIVEP2 | S41 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35568 | IRS1 | S766 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35749 | MYH11 | S1312 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38398 | BRCA1 | S891 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38398 | BRCA1 | S1598 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P49023 | PXN | S272 | ochoa|psp | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49748 | ACADVL | S588 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P49916 | LIG3 | S476 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P50747 | HLCS | S138 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P50851 | LRBA | S1133 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P53004 | BLVRA | S149 | psp | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
| P82094 | TMF1 | S23 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01082 | SPTBN1 | S781 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01484 | ANK2 | S1736 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02410 | APBA1 | S285 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q07157 | TJP1 | S992 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07820 | MCL1 | S159 | ochoa|psp | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}. |
| Q08378 | GOLGA3 | S395 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12756 | KIF1A | S1370 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12815 | TROAP | S278 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12851 | MAP4K2 | S367 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q12888 | TP53BP1 | S834 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13428 | TCOF1 | S1201 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13464 | ROCK1 | S1100 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13523 | PRP4K | S606 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14151 | SAFB2 | S287 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14152 | EIF3A | S1364 | psp | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q14651 | PLS1 | S112 | ochoa | Plastin-1 (Intestine-specific plastin) (I-plastin) | Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. {ECO:0000250|UniProtKB:Q3V0K9}. |
| Q14790 | CASP8 | S347 | psp | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| Q14980 | NUMA1 | S1145 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15020 | SART3 | S650 | ochoa | Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) | U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}. |
| Q15424 | SAFB | S288 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15555 | MAPRE2 | S253 | ochoa | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250|UniProtKB:Q8R001, ECO:0000269|PubMed:22373814, ECO:0000269|PubMed:23844040, ECO:0000269|PubMed:26527684, ECO:0000269|PubMed:27030108}. |
| Q16204 | CCDC6 | S328 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16658 | FSCN1 | S39 | ochoa|psp | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| Q2M1P5 | KIF7 | S1281 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q53GL7 | PARP10 | S663 | ochoa | Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10) | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). {ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:23332125, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:25043379}. |
| Q5JSH3 | WDR44 | S197 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5QJE6 | DNTTIP2 | S170 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5TCX8 | MAP3K21 | S635 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5TZA2 | CROCC | S1660 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5UIP0 | RIF1 | S1826 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZ89 | DENND4C | S1556 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6NY19 | KANK3 | S293 | ochoa | KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
| Q6NYC1 | JMJD6 | S23 | ochoa | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
| Q6P0N0 | MIS18BP1 | S894 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6ZMU5 | TRIM72 | S189 | ochoa | Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) | Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:Q1XH17, ECO:0000269|PubMed:36944613}. |
| Q6ZMU5 | TRIM72 | S301 | ochoa | Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) | Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:Q1XH17, ECO:0000269|PubMed:36944613}. |
| Q6ZV73 | FGD6 | S1197 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q76L83 | ASXL2 | S565 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7L7X3 | TAOK1 | S392 | ochoa | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7LBC6 | KDM3B | S608 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7LG56 | RRM2B | S20 | ochoa | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}. |
| Q7Z2Y5 | NRK | S1034 | ochoa | Nik-related protein kinase (EC 2.7.11.1) | May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}. |
| Q7Z406 | MYH14 | S1329 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z4H7 | HAUS6 | S429 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z4H7 | HAUS6 | S569 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q86X53 | ERICH1 | S339 | ochoa | Glutamate-rich protein 1 | None |
| Q8IW50 | FAM219A | S28 | ochoa | Protein FAM219A | None |
| Q8IWP9 | CCDC28A | S241 | ochoa | Coiled-coil domain-containing protein 28A (CCRL1AP) | None |
| Q8IWU2 | LMTK2 | S1246 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IXM2 | BACC1 | S146 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IZU2 | WDR17 | S1198 | ochoa | WD repeat-containing protein 17 | None |
| Q8N302 | AGGF1 | S135 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N3P4 | VPS8 | S32 | ochoa | Vacuolar protein sorting-associated protein 8 homolog | Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). {ECO:0000269|PubMed:25266290, ECO:0000305|PubMed:25266290}. |
| Q8N4S9 | MARVELD2 | S161 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8N573 | OXR1 | S381 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8NCD3 | HJURP | S116 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NCF5 | NFATC2IP | S142 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NDV7 | TNRC6A | S1209 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NEM2 | SHCBP1 | S267 | ochoa | SHC SH2 domain-binding protein 1 | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000250|UniProtKB:Q9Z179}. |
| Q8NEV8 | EXPH5 | S320 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEY1 | NAV1 | S490 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S3974 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NHL6 | LILRB1 | S619 | ochoa | Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j) | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:28636952, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}. |
| Q8TEU7 | RAPGEF6 | S1206 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TEW0 | PARD3 | S973 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF76 | HASPIN | S211 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WVM7 | STAG1 | S1204 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WX93 | PALLD | S941 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q92622 | RUBCN | S946 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q93074 | MED12 | S557 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96BY7 | ATG2B | S1751 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96GE4 | CEP95 | S192 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96JK2 | DCAF5 | S464 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96RL1 | UIMC1 | S430 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q99767 | APBA2 | S236 | psp | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Q9BQ39 | DDX50 | S117 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BQI3 | EIF2AK1 | S277 | ochoa | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}. |
| Q9BQS8 | FYCO1 | S580 | ochoa | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| Q9BUH8 | BEGAIN | S321 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BUQ8 | DDX23 | S143 | ochoa | Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) | Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). {ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:28076779}. |
| Q9BVJ6 | UTP14A | S52 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BZC7 | ABCA2 | S1327 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9H611 | PIF1 | S199 | ochoa | ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}. |
| Q9H799 | CPLANE1 | S156 | ochoa | Ciliogenesis and planar polarity effector 1 (Protein JBTS17) | Involved in ciliogenesis (PubMed:25877302, PubMed:35582950). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000269|PubMed:35582950, ECO:0000305|PubMed:25877302}. |
| Q9HB90 | RRAGC | S21 | ochoa|psp | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
| Q9NQG5 | RPRD1B | S145 | psp | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q9NQG7 | HPS4 | S355 | ochoa | BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog) | Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). {ECO:0000269|PubMed:23084991}. |
| Q9NWH9 | SLTM | S217 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NX63 | CHCHD3 | S50 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9NZ43 | USE1 | S146 | ochoa | Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31) | SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| Q9NZN4 | EHD2 | S373 | ochoa | EH domain-containing protein 2 (PAST homolog 2) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:25588833}. |
| Q9P244 | LRFN1 | S646 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9UDY2 | TJP2 | S948 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHC7 | MKRN1 | S133 | ochoa | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}. |
| Q9UHR4 | BAIAP2L1 | S394 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UIG0 | BAZ1B | S57 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UK61 | TASOR | S673 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKX7 | NUP50 | S223 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULF5 | SLC39A10 | S591 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9UNS1 | TIMELESS | S962 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9Y2H5 | PLEKHA6 | S591 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2J4 | AMOTL2 | S361 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2X3 | NOP58 | S304 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y4L1 | HYOU1 | S583 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9Y6A5 | TACC3 | S497 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6M5 | SLC30A1 | S199 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6Y0 | IVNS1ABP | S28 | ochoa | Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) | Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein (PubMed:23825951, PubMed:9696811). The BTB and Kelch domains are required for splicing activity (PubMed:30538201). Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF (PubMed:30538201). {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}. |
| P18754 | RCC1 | S85 | Sugiyama | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
| Q96SB3 | PPP1R9B | S94 | ELM|iPTMNet|EPSD | Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) | Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration. {ECO:0000250, ECO:0000269|PubMed:19151759}. |
| Q9BQ04 | RBM4B | S338 | Sugiyama | RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30) | Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). {ECO:0000250}. |
| Q9BWF3 | RBM4 | S343 | Sugiyama | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9H0C5 | BTBD1 | S273 | Sugiyama | BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8) | Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250|UniProtKB:P58544, ECO:0000269|PubMed:14528312}. |
| P33981 | TTK | S108 | SIGNOR|PSP | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35580 | MYH10 | S1312 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| Q15569 | TESK1 | S50 | Sugiyama | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q32MK0 | MYLK3 | S429 | Sugiyama | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q5S007 | LRRK2 | S1913 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q6XUX3 | DSTYK | S404 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-445355 | Smooth Muscle Contraction | 0.000078 | 4.110 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.000206 | 3.686 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.000462 | 3.335 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.000583 | 3.234 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.000726 | 3.139 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000982 | 3.008 |
| R-HSA-390522 | Striated Muscle Contraction | 0.001185 | 2.926 |
| R-HSA-2028269 | Signaling by Hippo | 0.002100 | 2.678 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.003553 | 2.449 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.003831 | 2.417 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003831 | 2.417 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.003960 | 2.402 |
| R-HSA-75153 | Apoptotic execution phase | 0.003484 | 2.458 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.005041 | 2.297 |
| R-HSA-397014 | Muscle contraction | 0.005218 | 2.283 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.007746 | 2.111 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.007377 | 2.132 |
| R-HSA-983189 | Kinesins | 0.007761 | 2.110 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.007084 | 2.150 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.007084 | 2.150 |
| R-HSA-373755 | Semaphorin interactions | 0.008988 | 2.046 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.009070 | 2.042 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.010811 | 1.966 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.012790 | 1.893 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.012790 | 1.893 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.011843 | 1.927 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.011843 | 1.927 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.016188 | 1.791 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.016188 | 1.791 |
| R-HSA-5693538 | Homology Directed Repair | 0.017720 | 1.752 |
| R-HSA-435354 | Zinc transporters | 0.018016 | 1.744 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.019010 | 1.721 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.019927 | 1.701 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.022352 | 1.651 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.022352 | 1.651 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.023443 | 1.630 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.023763 | 1.624 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.028359 | 1.547 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.027257 | 1.565 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.028359 | 1.547 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.028456 | 1.546 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.029349 | 1.532 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.054952 | 1.260 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.054952 | 1.260 |
| R-HSA-74713 | IRS activation | 0.076083 | 1.119 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.086471 | 1.063 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.086471 | 1.063 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.106901 | 0.971 |
| R-HSA-112412 | SOS-mediated signalling | 0.106901 | 0.971 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.106901 | 0.971 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.116944 | 0.932 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.116944 | 0.932 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.116944 | 0.932 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.126876 | 0.897 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.126876 | 0.897 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.136696 | 0.864 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.146407 | 0.834 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.165503 | 0.781 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.054290 | 1.265 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.193353 | 0.714 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.193353 | 0.714 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.202430 | 0.694 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.079113 | 1.102 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.237731 | 0.624 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.110335 | 0.957 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.246311 | 0.609 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.246311 | 0.609 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.246311 | 0.609 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.246311 | 0.609 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.246311 | 0.609 |
| R-HSA-774815 | Nucleosome assembly | 0.121360 | 0.916 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.121360 | 0.916 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.279681 | 0.553 |
| R-HSA-1221632 | Meiotic synapsis | 0.151937 | 0.818 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.295810 | 0.529 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.326999 | 0.485 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.334580 | 0.476 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.342075 | 0.466 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.342075 | 0.466 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.356814 | 0.448 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.356814 | 0.448 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.364061 | 0.439 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.378310 | 0.422 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.405864 | 0.392 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.299728 | 0.523 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.371226 | 0.430 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.211609 | 0.674 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.211609 | 0.674 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.211609 | 0.674 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.136696 | 0.864 |
| R-HSA-198203 | PI3K/AKT activation | 0.136696 | 0.864 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.146407 | 0.834 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.146407 | 0.834 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.371226 | 0.430 |
| R-HSA-191650 | Regulation of gap junction activity | 0.065577 | 1.183 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.086471 | 1.063 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.063094 | 1.200 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.064641 | 1.189 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.405864 | 0.392 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.340997 | 0.467 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.065577 | 1.183 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.076083 | 1.119 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.076083 | 1.119 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.096743 | 1.014 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.106901 | 0.971 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.126876 | 0.897 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.184174 | 0.735 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.356814 | 0.448 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.055761 | 1.254 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.364061 | 0.439 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.303740 | 0.517 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.377487 | 0.423 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.377487 | 0.423 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.228959 | 0.640 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.356814 | 0.448 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.303740 | 0.517 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.342075 | 0.466 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.126876 | 0.897 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.303740 | 0.517 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.308082 | 0.511 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.044208 | 1.355 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.065577 | 1.183 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.263184 | 0.580 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.271479 | 0.566 |
| R-HSA-9839394 | TGFBR3 expression | 0.295810 | 0.529 |
| R-HSA-8949613 | Cristae formation | 0.311580 | 0.506 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.326999 | 0.485 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.216546 | 0.664 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.155463 | 0.808 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.364061 | 0.439 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.371226 | 0.430 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.392242 | 0.406 |
| R-HSA-1500620 | Meiosis | 0.283088 | 0.548 |
| R-HSA-6807070 | PTEN Regulation | 0.259222 | 0.586 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.328681 | 0.483 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.340997 | 0.467 |
| R-HSA-68877 | Mitotic Prometaphase | 0.219615 | 0.658 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.378310 | 0.422 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.087148 | 1.060 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.334580 | 0.476 |
| R-HSA-74749 | Signal attenuation | 0.136696 | 0.864 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.060195 | 1.220 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.079113 | 1.102 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.106901 | 0.971 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.271479 | 0.566 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.364061 | 0.439 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.399092 | 0.399 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.072618 | 1.139 |
| R-HSA-196780 | Biotin transport and metabolism | 0.193353 | 0.714 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.346816 | 0.460 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.212422 | 0.673 |
| R-HSA-3214842 | HDMs demethylate histones | 0.048608 | 1.313 |
| R-HSA-9729555 | Sensory perception of sour taste | 0.065577 | 1.183 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.126876 | 0.897 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.156008 | 0.807 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.060195 | 1.220 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.254795 | 0.594 |
| R-HSA-420029 | Tight junction interactions | 0.295810 | 0.529 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.285132 | 0.545 |
| R-HSA-72312 | rRNA processing | 0.158450 | 0.800 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.217851 | 0.662 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.099596 | 1.002 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.263184 | 0.580 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.136696 | 0.864 |
| R-HSA-9842663 | Signaling by LTK | 0.165503 | 0.781 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.092613 | 1.033 |
| R-HSA-8951664 | Neddylation | 0.290704 | 0.537 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.165503 | 0.781 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.072618 | 1.139 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.334580 | 0.476 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.378310 | 0.422 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.044208 | 1.355 |
| R-HSA-389542 | NADPH regeneration | 0.096743 | 1.014 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.165503 | 0.781 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.174891 | 0.757 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.047395 | 1.324 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.066872 | 1.175 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.271479 | 0.566 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.171739 | 0.765 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.389211 | 0.410 |
| R-HSA-68886 | M Phase | 0.173627 | 0.760 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.106901 | 0.971 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.385316 | 0.414 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.054952 | 1.260 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.086471 | 1.063 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.126876 | 0.897 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.165503 | 0.781 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.165503 | 0.781 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.165503 | 0.781 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.254795 | 0.594 |
| R-HSA-200425 | Carnitine shuttle | 0.279681 | 0.553 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.378310 | 0.422 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.249745 | 0.603 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.356814 | 0.448 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.303312 | 0.518 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.202430 | 0.694 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.220279 | 0.657 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.125094 | 0.903 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.279681 | 0.553 |
| R-HSA-73894 | DNA Repair | 0.141162 | 0.850 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.074730 | 1.127 |
| R-HSA-446728 | Cell junction organization | 0.248800 | 0.604 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.399092 | 0.399 |
| R-HSA-75158 | TRAIL signaling | 0.086471 | 1.063 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.126876 | 0.897 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.051421 | 1.289 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.211405 | 0.675 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.039261 | 1.406 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.405864 | 0.392 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.299728 | 0.523 |
| R-HSA-70268 | Pyruvate metabolism | 0.295573 | 0.529 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.378310 | 0.422 |
| R-HSA-1500931 | Cell-Cell communication | 0.182197 | 0.739 |
| R-HSA-9659379 | Sensory processing of sound | 0.258078 | 0.588 |
| R-HSA-8848021 | Signaling by PTK6 | 0.191934 | 0.717 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.191934 | 0.717 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.279681 | 0.553 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.266763 | 0.574 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.058394 | 1.234 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.076083 | 1.119 |
| R-HSA-1268020 | Mitochondrial protein import | 0.187869 | 0.726 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.212422 | 0.673 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.287791 | 0.541 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.287791 | 0.541 |
| R-HSA-73886 | Chromosome Maintenance | 0.197149 | 0.705 |
| R-HSA-70171 | Glycolysis | 0.357307 | 0.447 |
| R-HSA-373760 | L1CAM interactions | 0.061092 | 1.214 |
| R-HSA-1640170 | Cell Cycle | 0.071329 | 1.147 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.229054 | 0.640 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.163764 | 0.786 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.311580 | 0.506 |
| R-HSA-69481 | G2/M Checkpoints | 0.217458 | 0.663 |
| R-HSA-211000 | Gene Silencing by RNA | 0.389471 | 0.410 |
| R-HSA-109581 | Apoptosis | 0.148137 | 0.829 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.323607 | 0.490 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.180142 | 0.744 |
| R-HSA-5357801 | Programmed Cell Death | 0.250955 | 0.600 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.165503 | 0.781 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.174891 | 0.757 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.349486 | 0.457 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.384824 | 0.415 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.124441 | 0.905 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.221497 | 0.655 |
| R-HSA-2586552 | Signaling by Leptin | 0.136696 | 0.864 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.263184 | 0.580 |
| R-HSA-194138 | Signaling by VEGF | 0.211609 | 0.674 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.144010 | 0.842 |
| R-HSA-9629569 | Protein hydroxylation | 0.246311 | 0.609 |
| R-HSA-210991 | Basigin interactions | 0.254795 | 0.594 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.303740 | 0.517 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.319333 | 0.496 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.287252 | 0.542 |
| R-HSA-4839726 | Chromatin organization | 0.361868 | 0.441 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.147032 | 0.833 |
| R-HSA-180292 | GAB1 signalosome | 0.229054 | 0.640 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.274755 | 0.561 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.312168 | 0.506 |
| R-HSA-199991 | Membrane Trafficking | 0.138505 | 0.859 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.263184 | 0.580 |
| R-HSA-373753 | Nephrin family interactions | 0.246311 | 0.609 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.237731 | 0.624 |
| R-HSA-425410 | Metal ion SLC transporters | 0.132642 | 0.877 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.271479 | 0.566 |
| R-HSA-422475 | Axon guidance | 0.310660 | 0.508 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.237731 | 0.624 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.271479 | 0.566 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.378310 | 0.422 |
| R-HSA-9675108 | Nervous system development | 0.373233 | 0.428 |
| R-HSA-2262752 | Cellular responses to stress | 0.393636 | 0.405 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.043089 | 1.366 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.096086 | 1.017 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.072618 | 1.139 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.303740 | 0.517 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.371226 | 0.430 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.050227 | 1.299 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.261795 | 0.582 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.146407 | 0.834 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.179775 | 0.745 |
| R-HSA-201556 | Signaling by ALK | 0.405864 | 0.392 |
| R-HSA-189483 | Heme degradation | 0.364061 | 0.439 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.092643 | 1.033 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.295810 | 0.529 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.279681 | 0.553 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.311604 | 0.506 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.200100 | 0.699 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.245581 | 0.610 |
| R-HSA-449147 | Signaling by Interleukins | 0.308971 | 0.510 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.295573 | 0.529 |
| R-HSA-69275 | G2/M Transition | 0.408989 | 0.388 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.412561 | 0.385 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.412561 | 0.385 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.412561 | 0.385 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.412561 | 0.385 |
| R-HSA-71240 | Tryptophan catabolism | 0.412561 | 0.385 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.415003 | 0.382 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.419182 | 0.378 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.419182 | 0.378 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.419182 | 0.378 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.419182 | 0.378 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.419182 | 0.378 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.425729 | 0.371 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.425729 | 0.371 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.425729 | 0.371 |
| R-HSA-165159 | MTOR signalling | 0.432203 | 0.364 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.432203 | 0.364 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.432924 | 0.364 |
| R-HSA-70326 | Glucose metabolism | 0.436319 | 0.360 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.436319 | 0.360 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.436319 | 0.360 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.437904 | 0.359 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.438604 | 0.358 |
| R-HSA-9609690 | HCMV Early Events | 0.438855 | 0.358 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.440138 | 0.356 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.444934 | 0.352 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.447261 | 0.349 |
| R-HSA-68875 | Mitotic Prophase | 0.447732 | 0.349 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.451192 | 0.346 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.451192 | 0.346 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.451507 | 0.345 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.457380 | 0.340 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.457380 | 0.340 |
| R-HSA-9675135 | Diseases of DNA repair | 0.457380 | 0.340 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.457380 | 0.340 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.457380 | 0.340 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.457380 | 0.340 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.459015 | 0.338 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.459015 | 0.338 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.462746 | 0.335 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.462746 | 0.335 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.463499 | 0.334 |
| R-HSA-437239 | Recycling pathway of L1 | 0.463499 | 0.334 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.463499 | 0.334 |
| R-HSA-72172 | mRNA Splicing | 0.465241 | 0.332 |
| R-HSA-9766229 | Degradation of CDH1 | 0.475532 | 0.323 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.475532 | 0.323 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.475532 | 0.323 |
| R-HSA-112316 | Neuronal System | 0.477055 | 0.321 |
| R-HSA-109704 | PI3K Cascade | 0.481447 | 0.317 |
| R-HSA-912446 | Meiotic recombination | 0.487296 | 0.312 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.488438 | 0.311 |
| R-HSA-1474165 | Reproduction | 0.492046 | 0.308 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.493079 | 0.307 |
| R-HSA-9843745 | Adipogenesis | 0.495638 | 0.305 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.498798 | 0.302 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.498798 | 0.302 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.498798 | 0.302 |
| R-HSA-9909396 | Circadian clock | 0.499214 | 0.302 |
| R-HSA-68882 | Mitotic Anaphase | 0.499556 | 0.301 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.502366 | 0.299 |
| R-HSA-8953854 | Metabolism of RNA | 0.503143 | 0.298 |
| R-HSA-72649 | Translation initiation complex formation | 0.504452 | 0.297 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.510043 | 0.292 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.510043 | 0.292 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.515571 | 0.288 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.515571 | 0.288 |
| R-HSA-75893 | TNF signaling | 0.515571 | 0.288 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.515571 | 0.288 |
| R-HSA-177929 | Signaling by EGFR | 0.515571 | 0.288 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.515571 | 0.288 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.516849 | 0.287 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.520327 | 0.284 |
| R-HSA-112399 | IRS-mediated signalling | 0.521037 | 0.283 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.521037 | 0.283 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.521037 | 0.283 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.526442 | 0.279 |
| R-HSA-191859 | snRNP Assembly | 0.531786 | 0.274 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.531786 | 0.274 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.531786 | 0.274 |
| R-HSA-180786 | Extension of Telomeres | 0.531786 | 0.274 |
| R-HSA-379724 | tRNA Aminoacylation | 0.537070 | 0.270 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.537070 | 0.270 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.537070 | 0.270 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.537070 | 0.270 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.537070 | 0.270 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.537070 | 0.270 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.537070 | 0.270 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.540842 | 0.267 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.542295 | 0.266 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.542295 | 0.266 |
| R-HSA-9707616 | Heme signaling | 0.547461 | 0.262 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.547461 | 0.262 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.547461 | 0.262 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.547461 | 0.262 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.552569 | 0.258 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.552569 | 0.258 |
| R-HSA-1266738 | Developmental Biology | 0.555684 | 0.255 |
| R-HSA-8939211 | ESR-mediated signaling | 0.556800 | 0.254 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.557472 | 0.254 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.557620 | 0.254 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.557620 | 0.254 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.557620 | 0.254 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.557620 | 0.254 |
| R-HSA-109582 | Hemostasis | 0.560910 | 0.251 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.562614 | 0.250 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.562614 | 0.250 |
| R-HSA-157118 | Signaling by NOTCH | 0.564657 | 0.248 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.567243 | 0.246 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.567552 | 0.246 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.567552 | 0.246 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.567552 | 0.246 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.572435 | 0.242 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.572435 | 0.242 |
| R-HSA-196807 | Nicotinate metabolism | 0.572435 | 0.242 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.573672 | 0.241 |
| R-HSA-9609507 | Protein localization | 0.576860 | 0.239 |
| R-HSA-5218859 | Regulated Necrosis | 0.577262 | 0.239 |
| R-HSA-1989781 | PPARA activates gene expression | 0.583184 | 0.234 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.586756 | 0.232 |
| R-HSA-9610379 | HCMV Late Events | 0.589439 | 0.230 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.589439 | 0.230 |
| R-HSA-162587 | HIV Life Cycle | 0.589439 | 0.230 |
| R-HSA-9609646 | HCMV Infection | 0.590230 | 0.229 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.591423 | 0.228 |
| R-HSA-8978934 | Metabolism of cofactors | 0.591423 | 0.228 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.591423 | 0.228 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.591423 | 0.228 |
| R-HSA-189445 | Metabolism of porphyrins | 0.591423 | 0.228 |
| R-HSA-421270 | Cell-cell junction organization | 0.592734 | 0.227 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.596037 | 0.225 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.600600 | 0.221 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.600600 | 0.221 |
| R-HSA-4086398 | Ca2+ pathway | 0.600600 | 0.221 |
| R-HSA-5688426 | Deubiquitination | 0.602652 | 0.220 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.605111 | 0.218 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.605111 | 0.218 |
| R-HSA-380287 | Centrosome maturation | 0.609572 | 0.215 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.609572 | 0.215 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.609572 | 0.215 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.609572 | 0.215 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.610784 | 0.214 |
| R-HSA-5689603 | UCH proteinases | 0.613983 | 0.212 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.613983 | 0.212 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.618344 | 0.209 |
| R-HSA-5619102 | SLC transporter disorders | 0.619672 | 0.208 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.622656 | 0.206 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.622656 | 0.206 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.622656 | 0.206 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.631135 | 0.200 |
| R-HSA-72306 | tRNA processing | 0.631279 | 0.200 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.633781 | 0.198 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.635303 | 0.197 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.636979 | 0.196 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.639425 | 0.194 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.639803 | 0.194 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.639803 | 0.194 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.647529 | 0.189 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.647529 | 0.189 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.651513 | 0.186 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.651513 | 0.186 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.655453 | 0.183 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.655453 | 0.183 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.659348 | 0.181 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.659348 | 0.181 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.659348 | 0.181 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.663199 | 0.178 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.665381 | 0.177 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.674494 | 0.171 |
| R-HSA-73884 | Base Excision Repair | 0.674494 | 0.171 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.674494 | 0.171 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.678175 | 0.169 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.685413 | 0.164 |
| R-HSA-391251 | Protein folding | 0.685413 | 0.164 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.685413 | 0.164 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.687730 | 0.163 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.692489 | 0.160 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.695968 | 0.157 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.695968 | 0.157 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.697667 | 0.156 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.699407 | 0.155 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.700084 | 0.155 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.702808 | 0.153 |
| R-HSA-157579 | Telomere Maintenance | 0.706170 | 0.151 |
| R-HSA-162582 | Signal Transduction | 0.707594 | 0.150 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.709494 | 0.149 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.709494 | 0.149 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.709494 | 0.149 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.709494 | 0.149 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.709675 | 0.149 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.714374 | 0.146 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.716032 | 0.145 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.716032 | 0.145 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.716032 | 0.145 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.719245 | 0.143 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.719245 | 0.143 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.722423 | 0.141 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.722423 | 0.141 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.722423 | 0.141 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.722423 | 0.141 |
| R-HSA-1483255 | PI Metabolism | 0.722423 | 0.141 |
| R-HSA-6805567 | Keratinization | 0.725845 | 0.139 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.728670 | 0.137 |
| R-HSA-9833110 | RSV-host interactions | 0.731742 | 0.136 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.734778 | 0.134 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.734778 | 0.134 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.741048 | 0.130 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.743685 | 0.129 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.743685 | 0.129 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.743685 | 0.129 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.746587 | 0.127 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.746587 | 0.127 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.749457 | 0.125 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.749457 | 0.125 |
| R-HSA-418990 | Adherens junctions interactions | 0.751801 | 0.124 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.755099 | 0.122 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.757873 | 0.120 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.757873 | 0.120 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.760615 | 0.119 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.763327 | 0.117 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.766008 | 0.116 |
| R-HSA-162906 | HIV Infection | 0.769863 | 0.114 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.771279 | 0.113 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.771279 | 0.113 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.771798 | 0.112 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.775625 | 0.110 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.776712 | 0.110 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.778966 | 0.108 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.778966 | 0.108 |
| R-HSA-3371556 | Cellular response to heat stress | 0.783948 | 0.106 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.786136 | 0.105 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.786396 | 0.104 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.786396 | 0.104 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.789204 | 0.103 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.798297 | 0.098 |
| R-HSA-597592 | Post-translational protein modification | 0.798711 | 0.098 |
| R-HSA-114608 | Platelet degranulation | 0.800519 | 0.097 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.802781 | 0.095 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.805962 | 0.094 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.811072 | 0.091 |
| R-HSA-9717189 | Sensory perception of taste | 0.811576 | 0.091 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.813713 | 0.090 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.815826 | 0.088 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.820509 | 0.086 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.824042 | 0.084 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.828012 | 0.082 |
| R-HSA-1632852 | Macroautophagy | 0.833802 | 0.079 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.837239 | 0.077 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.837553 | 0.077 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.846948 | 0.072 |
| R-HSA-69242 | S Phase | 0.848309 | 0.071 |
| R-HSA-166520 | Signaling by NTRKs | 0.848309 | 0.071 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.848309 | 0.071 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.851735 | 0.070 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.853418 | 0.069 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.855083 | 0.068 |
| R-HSA-69306 | DNA Replication | 0.856729 | 0.067 |
| R-HSA-73887 | Death Receptor Signaling | 0.858357 | 0.066 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.858357 | 0.066 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.859966 | 0.066 |
| R-HSA-9612973 | Autophagy | 0.861556 | 0.065 |
| R-HSA-9711097 | Cellular response to starvation | 0.864684 | 0.063 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.865858 | 0.063 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.867742 | 0.062 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.873653 | 0.059 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.874023 | 0.058 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.884697 | 0.053 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.889854 | 0.051 |
| R-HSA-9679506 | SARS-CoV Infections | 0.893172 | 0.049 |
| R-HSA-168255 | Influenza Infection | 0.894781 | 0.048 |
| R-HSA-2559583 | Cellular Senescence | 0.895979 | 0.048 |
| R-HSA-983712 | Ion channel transport | 0.906162 | 0.043 |
| R-HSA-5617833 | Cilium Assembly | 0.907230 | 0.042 |
| R-HSA-9824446 | Viral Infection Pathways | 0.907408 | 0.042 |
| R-HSA-6798695 | Neutrophil degranulation | 0.908739 | 0.042 |
| R-HSA-1280218 | Adaptive Immune System | 0.920281 | 0.036 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.928724 | 0.032 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.941354 | 0.026 |
| R-HSA-15869 | Metabolism of nucleotides | 0.945884 | 0.024 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.946502 | 0.024 |
| R-HSA-74160 | Gene expression (Transcription) | 0.947986 | 0.023 |
| R-HSA-212436 | Generic Transcription Pathway | 0.948317 | 0.023 |
| R-HSA-392499 | Metabolism of proteins | 0.955325 | 0.020 |
| R-HSA-8978868 | Fatty acid metabolism | 0.955673 | 0.020 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.957485 | 0.019 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.961644 | 0.017 |
| R-HSA-72766 | Translation | 0.964160 | 0.016 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.965041 | 0.015 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.972193 | 0.012 |
| R-HSA-1483257 | Phospholipid metabolism | 0.972553 | 0.012 |
| R-HSA-382551 | Transport of small molecules | 0.972788 | 0.012 |
| R-HSA-195721 | Signaling by WNT | 0.973486 | 0.012 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.980130 | 0.009 |
| R-HSA-1474244 | Extracellular matrix organization | 0.981884 | 0.008 |
| R-HSA-1643685 | Disease | 0.985118 | 0.007 |
| R-HSA-913531 | Interferon Signaling | 0.990190 | 0.004 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.990955 | 0.004 |
| R-HSA-168256 | Immune System | 0.993507 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.994114 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.994630 | 0.002 |
| R-HSA-5663205 | Infectious disease | 0.994840 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.999518 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999894 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999900 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999950 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999963 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.850 | 0.118 | 2 | 0.858 |
TBK1 |
0.841 | 0.319 | 1 | 0.629 |
IKKE |
0.841 | 0.353 | 1 | 0.650 |
RAF1 |
0.840 | 0.315 | 1 | 0.622 |
DSTYK |
0.838 | 0.160 | 2 | 0.877 |
IKKB |
0.837 | 0.138 | -2 | 0.782 |
CLK3 |
0.837 | 0.091 | 1 | 0.460 |
MTOR |
0.833 | 0.095 | 1 | 0.519 |
MST4 |
0.831 | 0.172 | 2 | 0.833 |
MOS |
0.830 | 0.014 | 1 | 0.512 |
CDC7 |
0.828 | -0.072 | 1 | 0.499 |
PRPK |
0.826 | -0.036 | -1 | 0.860 |
IKKA |
0.826 | 0.087 | -2 | 0.770 |
ULK2 |
0.825 | -0.002 | 2 | 0.759 |
NEK6 |
0.825 | 0.043 | -2 | 0.858 |
PIM3 |
0.825 | -0.019 | -3 | 0.772 |
GRK1 |
0.824 | 0.087 | -2 | 0.847 |
PRKD1 |
0.824 | 0.053 | -3 | 0.765 |
NEK7 |
0.824 | 0.044 | -3 | 0.818 |
KIS |
0.823 | 0.009 | 1 | 0.387 |
PDHK1 |
0.823 | 0.169 | 1 | 0.623 |
GCN2 |
0.822 | -0.120 | 2 | 0.768 |
PDHK4 |
0.822 | 0.027 | 1 | 0.581 |
BMPR2 |
0.822 | -0.004 | -2 | 0.888 |
CAMK2G |
0.821 | -0.016 | 2 | 0.822 |
NLK |
0.821 | -0.004 | 1 | 0.498 |
PKN2 |
0.821 | 0.071 | -3 | 0.797 |
WNK1 |
0.821 | 0.065 | -2 | 0.867 |
ATR |
0.820 | -0.037 | 1 | 0.501 |
NDR2 |
0.820 | -0.030 | -3 | 0.776 |
PKN3 |
0.820 | 0.006 | -3 | 0.760 |
CAMK1B |
0.820 | -0.027 | -3 | 0.809 |
SRPK1 |
0.820 | 0.052 | -3 | 0.685 |
CHAK2 |
0.819 | 0.031 | -1 | 0.841 |
MARK4 |
0.819 | 0.035 | 4 | 0.860 |
BCKDK |
0.818 | 0.116 | -1 | 0.805 |
HUNK |
0.818 | -0.011 | 2 | 0.775 |
BMPR1B |
0.818 | 0.050 | 1 | 0.462 |
PKCD |
0.818 | 0.080 | 2 | 0.779 |
TGFBR2 |
0.818 | 0.023 | -2 | 0.821 |
SKMLCK |
0.818 | 0.010 | -2 | 0.872 |
PRKD2 |
0.818 | 0.042 | -3 | 0.720 |
MLK1 |
0.818 | -0.007 | 2 | 0.795 |
FAM20C |
0.817 | 0.070 | 2 | 0.664 |
NIK |
0.817 | 0.028 | -3 | 0.832 |
NUAK2 |
0.817 | 0.001 | -3 | 0.791 |
AMPKA1 |
0.815 | 0.009 | -3 | 0.805 |
ERK5 |
0.815 | -0.061 | 1 | 0.472 |
ULK1 |
0.815 | -0.043 | -3 | 0.783 |
CDKL1 |
0.814 | -0.023 | -3 | 0.736 |
DNAPK |
0.814 | 0.137 | 1 | 0.546 |
PIM1 |
0.814 | 0.004 | -3 | 0.730 |
NDR1 |
0.813 | -0.029 | -3 | 0.780 |
RIPK3 |
0.813 | -0.051 | 3 | 0.702 |
WNK3 |
0.812 | -0.000 | 1 | 0.558 |
YSK4 |
0.812 | 0.180 | 1 | 0.587 |
SRPK2 |
0.812 | 0.047 | -3 | 0.612 |
TSSK2 |
0.812 | 0.020 | -5 | 0.841 |
CAMK2D |
0.812 | 0.019 | -3 | 0.794 |
RSK2 |
0.811 | -0.003 | -3 | 0.713 |
ATM |
0.811 | -0.031 | 1 | 0.463 |
TSSK1 |
0.811 | 0.037 | -3 | 0.818 |
CAMLCK |
0.811 | -0.017 | -2 | 0.863 |
GRK6 |
0.811 | -0.039 | 1 | 0.518 |
PKACG |
0.811 | 0.028 | -2 | 0.766 |
NEK9 |
0.811 | 0.009 | 2 | 0.805 |
GRK5 |
0.810 | -0.123 | -3 | 0.812 |
LATS2 |
0.810 | -0.011 | -5 | 0.762 |
DAPK2 |
0.810 | -0.039 | -3 | 0.813 |
HIPK4 |
0.810 | -0.035 | 1 | 0.442 |
AMPKA2 |
0.809 | 0.001 | -3 | 0.773 |
ANKRD3 |
0.809 | 0.013 | 1 | 0.557 |
TGFBR1 |
0.809 | 0.012 | -2 | 0.836 |
RSK3 |
0.808 | -0.012 | -3 | 0.702 |
GRK4 |
0.808 | -0.042 | -2 | 0.869 |
AURC |
0.808 | 0.051 | -2 | 0.678 |
CDK1 |
0.808 | -0.007 | 1 | 0.332 |
LATS1 |
0.808 | 0.074 | -3 | 0.789 |
GRK7 |
0.808 | 0.040 | 1 | 0.454 |
SRPK3 |
0.808 | 0.060 | -3 | 0.656 |
MLK3 |
0.808 | -0.001 | 2 | 0.739 |
CDK8 |
0.807 | -0.062 | 1 | 0.369 |
PKCB |
0.807 | 0.036 | 2 | 0.730 |
NEK2 |
0.807 | 0.111 | 2 | 0.788 |
NIM1 |
0.807 | -0.023 | 3 | 0.744 |
CDKL5 |
0.807 | -0.038 | -3 | 0.727 |
MAPKAPK3 |
0.807 | -0.029 | -3 | 0.734 |
PKCG |
0.807 | 0.054 | 2 | 0.737 |
DLK |
0.807 | -0.070 | 1 | 0.529 |
QSK |
0.807 | 0.037 | 4 | 0.838 |
ALK4 |
0.806 | 0.000 | -2 | 0.856 |
IRE1 |
0.806 | -0.038 | 1 | 0.468 |
CDK5 |
0.806 | -0.001 | 1 | 0.372 |
PLK1 |
0.806 | 0.002 | -2 | 0.822 |
TTBK2 |
0.806 | -0.023 | 2 | 0.690 |
CAMK2B |
0.805 | 0.005 | 2 | 0.793 |
P70S6KB |
0.805 | -0.017 | -3 | 0.745 |
CLK2 |
0.805 | 0.066 | -3 | 0.693 |
PKCA |
0.805 | 0.070 | 2 | 0.721 |
MASTL |
0.804 | -0.148 | -2 | 0.821 |
P90RSK |
0.804 | -0.033 | -3 | 0.707 |
ICK |
0.804 | -0.036 | -3 | 0.772 |
MAPKAPK2 |
0.804 | -0.032 | -3 | 0.684 |
JNK2 |
0.804 | -0.008 | 1 | 0.355 |
MNK2 |
0.804 | 0.031 | -2 | 0.801 |
PAK1 |
0.804 | -0.000 | -2 | 0.801 |
MLK2 |
0.804 | -0.081 | 2 | 0.794 |
SIK |
0.803 | 0.012 | -3 | 0.716 |
CDK19 |
0.803 | -0.057 | 1 | 0.345 |
PAK3 |
0.803 | -0.004 | -2 | 0.802 |
IRE2 |
0.803 | -0.015 | 2 | 0.736 |
PRKD3 |
0.803 | 0.009 | -3 | 0.694 |
ACVR2B |
0.802 | -0.016 | -2 | 0.831 |
PKACB |
0.802 | 0.041 | -2 | 0.700 |
CAMK2A |
0.802 | 0.001 | 2 | 0.810 |
QIK |
0.802 | -0.019 | -3 | 0.791 |
PAK6 |
0.802 | 0.076 | -2 | 0.717 |
JNK3 |
0.802 | -0.026 | 1 | 0.364 |
CHAK1 |
0.801 | 0.008 | 2 | 0.764 |
PKR |
0.801 | 0.006 | 1 | 0.524 |
PKCH |
0.801 | 0.030 | 2 | 0.711 |
CLK1 |
0.801 | 0.034 | -3 | 0.696 |
CLK4 |
0.800 | 0.013 | -3 | 0.714 |
PHKG1 |
0.800 | -0.012 | -3 | 0.779 |
RIPK1 |
0.800 | -0.129 | 1 | 0.493 |
TLK2 |
0.800 | 0.016 | 1 | 0.535 |
MSK2 |
0.800 | -0.030 | -3 | 0.683 |
ALK2 |
0.800 | 0.003 | -2 | 0.842 |
SGK3 |
0.800 | 0.043 | -3 | 0.716 |
CDK3 |
0.800 | 0.008 | 1 | 0.294 |
MST3 |
0.800 | 0.151 | 2 | 0.823 |
MARK3 |
0.800 | 0.023 | 4 | 0.793 |
PKCZ |
0.800 | -0.009 | 2 | 0.760 |
ACVR2A |
0.800 | -0.031 | -2 | 0.813 |
MLK4 |
0.799 | -0.038 | 2 | 0.701 |
AURA |
0.799 | 0.061 | -2 | 0.656 |
CAMK4 |
0.799 | -0.079 | -3 | 0.777 |
NUAK1 |
0.799 | -0.044 | -3 | 0.741 |
DYRK2 |
0.799 | -0.054 | 1 | 0.377 |
MEK1 |
0.799 | -0.051 | 2 | 0.816 |
BRAF |
0.799 | 0.053 | -4 | 0.833 |
AURB |
0.799 | 0.045 | -2 | 0.678 |
PLK4 |
0.799 | 0.022 | 2 | 0.607 |
CDK18 |
0.798 | -0.041 | 1 | 0.316 |
TAO3 |
0.798 | 0.140 | 1 | 0.547 |
MELK |
0.798 | -0.051 | -3 | 0.761 |
CDK13 |
0.797 | -0.046 | 1 | 0.356 |
PLK3 |
0.797 | -0.033 | 2 | 0.772 |
MNK1 |
0.797 | 0.013 | -2 | 0.814 |
MSK1 |
0.797 | 0.011 | -3 | 0.694 |
MARK2 |
0.797 | 0.009 | 4 | 0.766 |
GCK |
0.797 | 0.332 | 1 | 0.626 |
MEKK3 |
0.797 | 0.045 | 1 | 0.543 |
BRSK1 |
0.797 | -0.029 | -3 | 0.741 |
PKG2 |
0.797 | 0.036 | -2 | 0.696 |
BMPR1A |
0.797 | 0.003 | 1 | 0.449 |
CDK7 |
0.796 | -0.078 | 1 | 0.373 |
SMG1 |
0.796 | -0.067 | 1 | 0.480 |
RSK4 |
0.796 | -0.001 | -3 | 0.672 |
CK1G1 |
0.796 | 0.087 | -3 | 0.535 |
HIPK2 |
0.796 | -0.027 | 1 | 0.317 |
P38G |
0.796 | -0.041 | 1 | 0.284 |
PRKX |
0.796 | 0.036 | -3 | 0.631 |
AKT2 |
0.796 | 0.026 | -3 | 0.637 |
CK1E |
0.796 | 0.021 | -3 | 0.543 |
HPK1 |
0.795 | 0.361 | 1 | 0.648 |
MYLK4 |
0.795 | -0.012 | -2 | 0.802 |
ERK1 |
0.795 | -0.043 | 1 | 0.354 |
MINK |
0.795 | 0.351 | 1 | 0.635 |
TNIK |
0.795 | 0.293 | 3 | 0.864 |
P38B |
0.795 | -0.038 | 1 | 0.355 |
TLK1 |
0.794 | 0.039 | -2 | 0.866 |
KHS1 |
0.794 | 0.401 | 1 | 0.661 |
CDK2 |
0.794 | -0.035 | 1 | 0.385 |
BRSK2 |
0.794 | -0.040 | -3 | 0.774 |
ZAK |
0.794 | 0.013 | 1 | 0.530 |
VRK2 |
0.794 | -0.150 | 1 | 0.522 |
KHS2 |
0.794 | 0.380 | 1 | 0.666 |
CDK17 |
0.793 | -0.055 | 1 | 0.282 |
MEKK1 |
0.793 | 0.013 | 1 | 0.546 |
P38A |
0.793 | -0.052 | 1 | 0.395 |
MEKK2 |
0.793 | 0.044 | 2 | 0.774 |
PAK2 |
0.793 | -0.029 | -2 | 0.787 |
NEK5 |
0.793 | 0.023 | 1 | 0.527 |
GRK2 |
0.792 | -0.063 | -2 | 0.767 |
MARK1 |
0.792 | -0.005 | 4 | 0.818 |
MST2 |
0.792 | 0.212 | 1 | 0.607 |
HGK |
0.791 | 0.255 | 3 | 0.862 |
HIPK1 |
0.791 | -0.030 | 1 | 0.388 |
PKCT |
0.791 | 0.030 | 2 | 0.717 |
CDK12 |
0.791 | -0.048 | 1 | 0.342 |
SSTK |
0.791 | 0.011 | 4 | 0.846 |
DCAMKL1 |
0.790 | -0.027 | -3 | 0.741 |
SNRK |
0.790 | -0.094 | 2 | 0.667 |
PHKG2 |
0.790 | 0.039 | -3 | 0.758 |
HRI |
0.790 | -0.047 | -2 | 0.856 |
CHK1 |
0.790 | -0.046 | -3 | 0.777 |
PIM2 |
0.789 | -0.014 | -3 | 0.694 |
PINK1 |
0.789 | -0.090 | 1 | 0.471 |
WNK4 |
0.789 | -0.008 | -2 | 0.846 |
MEK5 |
0.789 | -0.058 | 2 | 0.798 |
NEK11 |
0.789 | 0.102 | 1 | 0.565 |
AKT1 |
0.788 | 0.037 | -3 | 0.661 |
CK1D |
0.788 | 0.037 | -3 | 0.501 |
MPSK1 |
0.788 | 0.006 | 1 | 0.462 |
PKACA |
0.787 | 0.036 | -2 | 0.649 |
DRAK1 |
0.787 | -0.124 | 1 | 0.439 |
CDK9 |
0.787 | -0.072 | 1 | 0.364 |
TAK1 |
0.787 | 0.206 | 1 | 0.600 |
ERK2 |
0.787 | -0.074 | 1 | 0.368 |
PERK |
0.786 | -0.081 | -2 | 0.845 |
TAO2 |
0.786 | 0.092 | 2 | 0.836 |
DYRK4 |
0.786 | -0.043 | 1 | 0.330 |
NEK4 |
0.786 | 0.182 | 1 | 0.587 |
CAMK1G |
0.786 | -0.071 | -3 | 0.712 |
CDK16 |
0.786 | -0.036 | 1 | 0.293 |
P38D |
0.785 | -0.039 | 1 | 0.303 |
IRAK4 |
0.785 | -0.060 | 1 | 0.490 |
CK2A2 |
0.785 | -0.011 | 1 | 0.415 |
PRP4 |
0.784 | -0.051 | -3 | 0.691 |
MST1 |
0.784 | 0.229 | 1 | 0.611 |
HIPK3 |
0.784 | -0.039 | 1 | 0.405 |
CK1A2 |
0.784 | 0.024 | -3 | 0.499 |
GAK |
0.784 | -0.003 | 1 | 0.502 |
CDK10 |
0.784 | -0.014 | 1 | 0.338 |
PKCI |
0.783 | 0.021 | 2 | 0.728 |
NEK8 |
0.783 | -0.021 | 2 | 0.799 |
MAPKAPK5 |
0.783 | -0.103 | -3 | 0.674 |
DYRK1A |
0.783 | -0.057 | 1 | 0.409 |
CDK14 |
0.783 | -0.052 | 1 | 0.356 |
DCAMKL2 |
0.782 | -0.042 | -3 | 0.766 |
SMMLCK |
0.782 | -0.031 | -3 | 0.762 |
EEF2K |
0.782 | 0.079 | 3 | 0.866 |
PKCE |
0.782 | 0.046 | 2 | 0.722 |
CAMKK1 |
0.782 | -0.033 | -2 | 0.756 |
MAP3K15 |
0.781 | 0.072 | 1 | 0.528 |
PAK5 |
0.780 | 0.023 | -2 | 0.664 |
MEKK6 |
0.780 | 0.056 | 1 | 0.538 |
PASK |
0.780 | -0.068 | -3 | 0.785 |
DYRK1B |
0.780 | -0.063 | 1 | 0.336 |
TTBK1 |
0.779 | -0.049 | 2 | 0.618 |
GRK3 |
0.779 | -0.058 | -2 | 0.736 |
LOK |
0.778 | 0.116 | -2 | 0.784 |
LKB1 |
0.778 | -0.022 | -3 | 0.795 |
PDK1 |
0.778 | -0.018 | 1 | 0.519 |
SLK |
0.778 | 0.102 | -2 | 0.737 |
JNK1 |
0.777 | -0.051 | 1 | 0.331 |
CAMKK2 |
0.777 | -0.050 | -2 | 0.748 |
PKN1 |
0.777 | -0.003 | -3 | 0.683 |
PAK4 |
0.777 | 0.021 | -2 | 0.668 |
CDK6 |
0.777 | -0.016 | 1 | 0.342 |
DYRK3 |
0.777 | -0.051 | 1 | 0.389 |
DAPK3 |
0.776 | -0.023 | -3 | 0.748 |
P70S6K |
0.776 | -0.035 | -3 | 0.658 |
NEK1 |
0.775 | 0.069 | 1 | 0.529 |
CAMK1D |
0.775 | -0.046 | -3 | 0.641 |
IRAK1 |
0.774 | -0.116 | -1 | 0.734 |
CK2A1 |
0.774 | -0.024 | 1 | 0.403 |
MRCKB |
0.773 | 0.053 | -3 | 0.690 |
YSK1 |
0.773 | 0.080 | 2 | 0.781 |
PLK2 |
0.772 | -0.025 | -3 | 0.726 |
AKT3 |
0.772 | 0.017 | -3 | 0.575 |
GSK3B |
0.772 | -0.027 | 4 | 0.427 |
ERK7 |
0.772 | -0.034 | 2 | 0.525 |
CDK4 |
0.771 | -0.036 | 1 | 0.336 |
SGK1 |
0.771 | 0.017 | -3 | 0.559 |
GSK3A |
0.771 | -0.029 | 4 | 0.438 |
ROCK2 |
0.771 | 0.051 | -3 | 0.739 |
CHK2 |
0.771 | 0.001 | -3 | 0.593 |
MRCKA |
0.770 | 0.040 | -3 | 0.710 |
LRRK2 |
0.770 | -0.023 | 2 | 0.827 |
DAPK1 |
0.769 | -0.037 | -3 | 0.726 |
MAK |
0.767 | -0.016 | -2 | 0.699 |
MYO3A |
0.766 | 0.181 | 1 | 0.574 |
RIPK2 |
0.766 | -0.089 | 1 | 0.525 |
STK33 |
0.765 | -0.080 | 2 | 0.606 |
OSR1 |
0.765 | 0.029 | 2 | 0.758 |
BUB1 |
0.764 | 0.000 | -5 | 0.808 |
PBK |
0.764 | -0.047 | 1 | 0.464 |
CAMK1A |
0.764 | -0.035 | -3 | 0.609 |
VRK1 |
0.763 | -0.150 | 2 | 0.818 |
MEK2 |
0.763 | -0.063 | 2 | 0.780 |
MYO3B |
0.761 | 0.094 | 2 | 0.810 |
ROCK1 |
0.761 | 0.047 | -3 | 0.708 |
TTK |
0.761 | 0.010 | -2 | 0.836 |
DMPK1 |
0.760 | 0.023 | -3 | 0.717 |
TAO1 |
0.759 | 0.084 | 1 | 0.537 |
HASPIN |
0.759 | -0.002 | -1 | 0.697 |
PKG1 |
0.759 | 0.005 | -2 | 0.622 |
NEK3 |
0.759 | -0.028 | 1 | 0.515 |
PDHK3_TYR |
0.758 | 0.038 | 4 | 0.910 |
ASK1 |
0.758 | 0.019 | 1 | 0.520 |
MOK |
0.757 | -0.060 | 1 | 0.382 |
SBK |
0.755 | -0.033 | -3 | 0.527 |
BIKE |
0.753 | -0.040 | 1 | 0.425 |
CK1A |
0.752 | 0.000 | -3 | 0.416 |
MAP2K4_TYR |
0.751 | -0.039 | -1 | 0.884 |
MAP2K6_TYR |
0.751 | -0.026 | -1 | 0.888 |
BMPR2_TYR |
0.750 | 0.026 | -1 | 0.887 |
PDHK4_TYR |
0.750 | -0.031 | 2 | 0.871 |
CRIK |
0.749 | -0.002 | -3 | 0.652 |
TESK1_TYR |
0.749 | -0.073 | 3 | 0.837 |
YANK3 |
0.748 | -0.045 | 2 | 0.411 |
ALPHAK3 |
0.748 | -0.067 | -1 | 0.788 |
PDHK1_TYR |
0.747 | -0.042 | -1 | 0.889 |
MAP2K7_TYR |
0.747 | -0.095 | 2 | 0.846 |
TYK2 |
0.747 | 0.104 | 1 | 0.549 |
PKMYT1_TYR |
0.745 | -0.107 | 3 | 0.795 |
PINK1_TYR |
0.745 | -0.125 | 1 | 0.499 |
EPHA6 |
0.744 | 0.006 | -1 | 0.862 |
STLK3 |
0.743 | -0.028 | 1 | 0.532 |
LIMK2_TYR |
0.743 | -0.043 | -3 | 0.847 |
RET |
0.743 | 0.014 | 1 | 0.532 |
ROS1 |
0.742 | 0.043 | 3 | 0.729 |
JAK2 |
0.742 | 0.061 | 1 | 0.545 |
CSF1R |
0.741 | 0.012 | 3 | 0.737 |
JAK1 |
0.741 | 0.147 | 1 | 0.547 |
AAK1 |
0.741 | -0.014 | 1 | 0.358 |
MST1R |
0.739 | -0.019 | 3 | 0.746 |
NEK10_TYR |
0.738 | 0.086 | 1 | 0.508 |
JAK3 |
0.738 | -0.030 | 1 | 0.488 |
ABL2 |
0.738 | -0.029 | -1 | 0.798 |
CK1G3 |
0.738 | 0.051 | -3 | 0.370 |
INSRR |
0.738 | -0.003 | 3 | 0.694 |
EPHB4 |
0.737 | -0.063 | -1 | 0.829 |
TXK |
0.737 | -0.050 | 1 | 0.490 |
TYRO3 |
0.737 | -0.086 | 3 | 0.752 |
LIMK1_TYR |
0.736 | -0.145 | 2 | 0.837 |
LCK |
0.735 | -0.005 | -1 | 0.811 |
FGR |
0.734 | -0.095 | 1 | 0.516 |
BLK |
0.734 | -0.014 | -1 | 0.814 |
DDR1 |
0.734 | -0.114 | 4 | 0.859 |
HCK |
0.734 | -0.047 | -1 | 0.806 |
YES1 |
0.734 | -0.093 | -1 | 0.812 |
FLT3 |
0.733 | -0.017 | 3 | 0.757 |
ABL1 |
0.733 | -0.055 | -1 | 0.786 |
KIT |
0.732 | -0.039 | 3 | 0.733 |
TNNI3K_TYR |
0.731 | 0.003 | 1 | 0.515 |
FER |
0.731 | -0.132 | 1 | 0.526 |
KDR |
0.729 | -0.043 | 3 | 0.703 |
PDGFRB |
0.729 | -0.096 | 3 | 0.758 |
ITK |
0.729 | -0.092 | -1 | 0.776 |
EPHA4 |
0.729 | -0.068 | 2 | 0.777 |
TNK2 |
0.728 | -0.087 | 3 | 0.699 |
SRMS |
0.728 | -0.109 | 1 | 0.520 |
EPHB1 |
0.727 | -0.098 | 1 | 0.522 |
FGFR2 |
0.727 | -0.105 | 3 | 0.722 |
EPHB2 |
0.726 | -0.078 | -1 | 0.805 |
TNK1 |
0.725 | -0.063 | 3 | 0.729 |
FYN |
0.724 | -0.037 | -1 | 0.786 |
BMX |
0.724 | -0.067 | -1 | 0.700 |
EPHB3 |
0.724 | -0.109 | -1 | 0.808 |
MET |
0.724 | -0.085 | 3 | 0.713 |
FLT1 |
0.723 | -0.061 | -1 | 0.851 |
FRK |
0.723 | -0.032 | -1 | 0.814 |
ERBB2 |
0.723 | -0.062 | 1 | 0.500 |
BTK |
0.722 | -0.101 | -1 | 0.732 |
MERTK |
0.722 | -0.112 | 3 | 0.698 |
FGFR1 |
0.722 | -0.118 | 3 | 0.696 |
TEC |
0.722 | -0.077 | -1 | 0.698 |
PDGFRA |
0.722 | -0.091 | 3 | 0.758 |
ALK |
0.722 | -0.063 | 3 | 0.665 |
WEE1_TYR |
0.722 | -0.056 | -1 | 0.736 |
TEK |
0.721 | -0.119 | 3 | 0.679 |
INSR |
0.720 | -0.081 | 3 | 0.669 |
FGFR3 |
0.719 | -0.086 | 3 | 0.695 |
AXL |
0.719 | -0.133 | 3 | 0.698 |
EGFR |
0.718 | -0.059 | 1 | 0.418 |
EPHA7 |
0.718 | -0.084 | 2 | 0.773 |
NTRK1 |
0.718 | -0.128 | -1 | 0.815 |
YANK2 |
0.718 | -0.053 | 2 | 0.427 |
LTK |
0.718 | -0.099 | 3 | 0.675 |
CK1G2 |
0.717 | 0.016 | -3 | 0.458 |
LYN |
0.717 | -0.083 | 3 | 0.663 |
SYK |
0.716 | -0.001 | -1 | 0.797 |
FLT4 |
0.715 | -0.112 | 3 | 0.689 |
NTRK2 |
0.715 | -0.136 | 3 | 0.691 |
DDR2 |
0.715 | -0.079 | 3 | 0.675 |
PTK2 |
0.714 | -0.016 | -1 | 0.815 |
EPHA3 |
0.714 | -0.106 | 2 | 0.748 |
EPHA1 |
0.714 | -0.094 | 3 | 0.692 |
PTK6 |
0.713 | -0.159 | -1 | 0.703 |
NTRK3 |
0.712 | -0.126 | -1 | 0.768 |
EPHA5 |
0.712 | -0.084 | 2 | 0.761 |
SRC |
0.712 | -0.100 | -1 | 0.775 |
MATK |
0.711 | -0.101 | -1 | 0.730 |
FGFR4 |
0.711 | -0.051 | -1 | 0.771 |
EPHA8 |
0.710 | -0.094 | -1 | 0.794 |
CSK |
0.708 | -0.107 | 2 | 0.772 |
PTK2B |
0.707 | -0.143 | -1 | 0.734 |
ERBB4 |
0.707 | -0.049 | 1 | 0.430 |
IGF1R |
0.705 | -0.086 | 3 | 0.600 |
MUSK |
0.704 | -0.110 | 1 | 0.408 |
EPHA2 |
0.702 | -0.085 | -1 | 0.777 |
ZAP70 |
0.698 | -0.025 | -1 | 0.720 |
FES |
0.682 | -0.154 | -1 | 0.673 |