Motif 750 (n=186)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S685 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A8K0Z3 | WASHC1 | S219 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MT19 | RHPN2P1 | S495 | ochoa | Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) | None |
| A8MWX3 | WASH4P | S232 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| C4AMC7 | WASH3P | S217 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| O14545 | TRAFD1 | S272 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14737 | PDCD5 | S51 | ochoa | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | May function in the process of apoptosis. |
| O43149 | ZZEF1 | S1276 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
| O43663 | PRC1 | S472 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43683 | BUB1 | S318 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60271 | SPAG9 | S272 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75182 | SIN3B | S640 | ochoa | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| O75616 | ERAL1 | S173 | ochoa|psp | GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1) | Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. {ECO:0000269|PubMed:20430825, ECO:0000269|PubMed:20604745, ECO:0000269|PubMed:28449065}. |
| O75717 | WDHD1 | S333 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O75762 | TRPA1 | S43 | ochoa | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O94953 | KDM4B | S1041 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95239 | KIF4A | S1001 | ochoa|psp | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95436 | SLC34A2 | S55 | ochoa | Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) | Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}. |
| O95801 | TTC4 | S51 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| O95999 | BCL10 | S170 | psp | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| O96028 | NSD2 | S56 | ochoa|psp | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P00338 | LDHA | S274 | ochoa | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P04350 | TUBB4A | S338 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05141 | SLC25A5 | S42 | ochoa | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P51881, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:31883789}. |
| P06213 | INSR | S1064 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P06744 | GPI | S107 | ochoa | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
| P06748 | NPM1 | S139 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07237 | P4HB | S190 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07437 | TUBB | S338 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08670 | VIM | S438 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P11831 | SRF | S253 | psp | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P12235 | SLC25A4 | S42 | ochoa | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:21586654, PubMed:27693233). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:21586654, ECO:0000269|PubMed:27693233, ECO:0000269|PubMed:31883789}. |
| P12236 | SLC25A6 | S42 | ochoa | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}. |
| P13010 | XRCC5 | S712 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13796 | LCP1 | S406 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P14316 | IRF2 | S152 | ochoa | Interferon regulatory factor 2 (IRF-2) | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}. |
| P15822 | HIVEP1 | S670 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P18858 | LIG1 | S819 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P21359 | NF1 | S2587 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P27815 | PDE4A | S157 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P31321 | PRKAR1B | S73 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
| P33151 | CDH5 | S665 | psp | Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) | Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120). Associates with CTNND1/p120-catenin to control CADH5 endocytosis (By similarity). {ECO:0000250|UniProtKB:P55284, ECO:0000250|UniProtKB:Q8AYD0, ECO:0000269|PubMed:10861224, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}. |
| P34932 | HSPA4 | S756 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P39748 | FEN1 | S331 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P40337 | VHL | S68 | ochoa|psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
| P46087 | NOP2 | S40 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P49841 | GSK3B | S25 | ochoa | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:11430833, PubMed:12554650, PubMed:14690523, PubMed:16484495, PubMed:1846781, PubMed:20937854, PubMed:9072970). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282, PubMed:25827072, PubMed:29059170). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (PubMed:21343617). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
| P50402 | EMD | S110 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50402 | EMD | S120 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50552 | VASP | S46 | ochoa | Vasodilator-stimulated phosphoprotein (VASP) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| P51397 | DAP | S51 | ochoa|psp | Death-associated protein 1 (DAP-1) | Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). {ECO:0000250|UniProtKB:Q9I9N1, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:7828849}. |
| P52757 | CHN2 | S167 | psp | Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| P54252 | ATXN3 | S256 | psp | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P54296 | MYOM2 | S462 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P61026 | RAB10 | S181 | ochoa | Ras-related protein Rab-10 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}.; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. {ECO:0000269|PubMed:31540829}. |
| P68371 | TUBB4B | S338 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78352 | DLG4 | S422 | ochoa | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| Q00341 | HDLBP | S804 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q03001 | DST | S2553 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q05682 | CALD1 | S660 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q07021 | C1QBP | S213 | ochoa | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}. |
| Q07666 | KHDRBS1 | S390 | psp | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q08357 | SLC20A2 | S424 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08AD1 | CAMSAP2 | S715 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q08AD1 | CAMSAP2 | S844 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q08AE8 | SPIRE1 | S479 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
| Q12882 | DPYD | S436 | ochoa | Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) | Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). {ECO:0000269|PubMed:1512248}. |
| Q12888 | TP53BP1 | S202 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12959 | DLG1 | S575 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q13043 | STK4 | S82 | psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13415 | ORC1 | S345 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13485 | SMAD4 | S343 | psp | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) | In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:9389648}. |
| Q13509 | TUBB3 | S338 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | S338 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q13905 | RAPGEF1 | S375 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14008 | CKAP5 | S1471 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14155 | ARHGEF7 | S581 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14432 | PDE3A | S657 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14692 | BMS1 | S558 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q14966 | ZNF638 | S279 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14978 | NOLC1 | S643 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15054 | POLD3 | S409 | ochoa | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15652 | JMJD1C | S1058 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15653 | NFKBIB | S315 | psp | NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9) | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Q16513 | PKN2 | S19 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q17R98 | ZNF827 | S504 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q5FBB7 | SGO1 | S129 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5T1R4 | HIVEP3 | S1052 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5Y3 | CAMSAP1 | S722 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TGY3 | AHDC1 | S596 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VT52 | RPRD2 | S1092 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VWN6 | TASOR2 | S867 | ochoa | Protein TASOR 2 | None |
| Q6AI08 | HEATR6 | S499 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6STE5 | SMARCD3 | S247 | psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6P9Z1, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:8804307, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q6VEQ5 | WASH2P | S219 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6WKZ4 | RAB11FIP1 | S156 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZS17 | RIPOR1 | S330 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q7L7X3 | TAOK1 | S174 | ochoa | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7RTP6 | MICAL3 | S1346 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2Z1 | TICRR | S441 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z4H7 | HAUS6 | S530 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z7L9 | ZSCAN2 | S168 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q86SQ0 | PHLDB2 | S277 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86WP2 | GPBP1 | S50 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q8IUC4 | RHPN2 | S598 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8IWB9 | TEX2 | S464 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IZT6 | ASPM | S3428 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N163 | CCAR2 | S478 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N3E9 | PLCD3 | S573 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}. |
| Q8N3J5 | PPM1K | S248 | ochoa | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715). {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715, ECO:0000269|PubMed:19411760, ECO:0000269|PubMed:22291014, ECO:0000269|PubMed:22589535, ECO:0000269|PubMed:23086801, ECO:0000269|PubMed:29779826}. |
| Q8N3U4 | STAG2 | S1177 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
| Q8N573 | OXR1 | S323 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N573 | OXR1 | S363 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N6H7 | ARFGAP2 | S317 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NAN2 | MIGA1 | S293 | ochoa | Mitoguardin 1 (Protein FAM73A) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q8NCN4 | RNF169 | S471 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NEF9 | SRFBP1 | S349 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NEY8 | PPHLN1 | S201 | ochoa | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| Q8TF01 | PNISR | S467 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WVM7 | STAG1 | S1204 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WWI1 | LMO7 | S257 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXH0 | SYNE2 | S6377 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WYP5 | AHCTF1 | S1548 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92667 | AKAP1 | S274 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q96BN8 | OTULIN | S76 | ochoa | Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) | Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327, PubMed:26997266, PubMed:27523608, PubMed:27559085, PubMed:28919039, PubMed:30804083, PubMed:35170849, PubMed:35587511, PubMed:38630025, PubMed:38652464). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334). {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:23806334, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:24726323, ECO:0000269|PubMed:24726327, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27523608, ECO:0000269|PubMed:27559085, ECO:0000269|PubMed:28919039, ECO:0000269|PubMed:30804083, ECO:0000269|PubMed:35170849, ECO:0000269|PubMed:35587511, ECO:0000269|PubMed:38630025, ECO:0000269|PubMed:38652464}. |
| Q96EB6 | SIRT1 | S174 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96FS4 | SIPA1 | S839 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96JI7 | SPG11 | S1957 | ochoa | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) | May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}. |
| Q96L93 | KIF16B | S575 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96R06 | SPAG5 | S159 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RU3 | FNBP1 | S386 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q99590 | SCAF11 | S530 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99590 | SCAF11 | S1012 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99959 | PKP2 | S71 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BUF5 | TUBB6 | S338 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S338 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BX66 | SORBS1 | S481 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXF6 | RAB11FIP5 | S176 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXS6 | NUSAP1 | S305 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BYF1 | ACE2 | S680 | psp | Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2] | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10924499, PubMed:10969042, PubMed:11815627, PubMed:14504186, PubMed:19021774). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:14504186, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19021774, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:27217402}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467, ECO:0000269|PubMed:19901337, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32225175, ECO:0000269|PubMed:33000221, ECO:0000269|PubMed:33082294, ECO:0000269|PubMed:33432067}.; FUNCTION: [Isoform 2]: Non-functional as a carboxypeptidase. {ECO:0000269|PubMed:33077916}.; FUNCTION: [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33077916, ECO:0000269|PubMed:33432184}. |
| Q9C0C2 | TNKS1BP1 | S244 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H2K8 | TAOK3 | S170 | ochoa | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
| Q9H3C7 | GGNBP2 | S413 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
| Q9H6K1 | ILRUN | S237 | ochoa | Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) | Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}. |
| Q9HA38 | ZMAT3 | S158 | ochoa | Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein) | Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. {ECO:0000269|PubMed:11571644}. |
| Q9HAK2 | EBF2 | S161 | ochoa | Transcription factor COE2 (Early B-cell factor 2) (EBF-2) | Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). {ECO:0000250}. |
| Q9HC77 | CPAP | S663 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HC78 | ZBTB20 | S377 | ochoa | Zinc finger and BTB domain-containing protein 20 (Dendritic-derived BTB/POZ zinc finger protein) (Zinc finger protein 288) | May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q8K0L9, ECO:0000269|PubMed:11352661}. |
| Q9HCH5 | SYTL2 | S321 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCK8 | CHD8 | S296 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NQA3 | WASH6P | S201 | ochoa | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9NQW6 | ANLN | S678 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NU22 | MDN1 | S5128 | ochoa | Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein) | Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}. |
| Q9NVI1 | FANCI | S730 | ochoa|psp | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NW64 | RBM22 | S128 | ochoa | Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:22246180, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154}. |
| Q9NYA4 | MTMR4 | S594 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}. |
| Q9P2K8 | EIF2AK4 | S1515 | ochoa | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| Q9P2Y5 | UVRAG | S554 | ochoa | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UBC2 | EPS15L1 | S575 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBZ4 | APEX2 | S227 | ochoa | DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}. |
| Q9UEY8 | ADD3 | S652 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UH92 | MLX | S98 | ochoa | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9UHE8 | STEAP1 | S36 | ochoa | STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) | Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. {ECO:0000269|PubMed:32409586}. |
| Q9UJY5 | GGA1 | S185 | ochoa | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}. |
| Q9UKX7 | NUP50 | S204 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULH0 | KIDINS220 | S1740 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULI0 | ATAD2B | S83 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULW0 | TPX2 | S101 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UMN6 | KMT2B | S2318 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPN6 | SCAF8 | S780 | ochoa | SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
| Q9UQE7 | SMC3 | S1085 | ochoa | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| Q9Y250 | LZTS1 | S174 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2H0 | DLGAP4 | S709 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2W1 | THRAP3 | S619 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4B5 | MTCL1 | S1387 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4L1 | HYOU1 | S582 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9Y6M5 | SLC30A1 | S199 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| O94768 | STK17B | S351 | Sugiyama | Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) | Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. {ECO:0000250, ECO:0000269|PubMed:9786912}. |
| P00519 | ABL1 | S553 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| Q9BQ52 | ELAC2 | S229 | Sugiyama | Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}. |
| P19429 | TNNI3 | S77 | SIGNOR|iPTMNet|EPSD | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P62258 | YWHAE | S156 | Sugiyama | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P35606 | COPB2 | S195 | Sugiyama | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| P21980 | TGM2 | S365 | Sugiyama | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| Q13873 | BMPR2 | S522 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q01518 | CAP1 | S25 | Sugiyama | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-68877 | Mitotic Prometaphase | 9.226508e-12 | 11.035 |
| R-HSA-1640170 | Cell Cycle | 2.785705e-11 | 10.555 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.556888e-11 | 10.341 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.336209e-11 | 10.363 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.382901e-09 | 8.859 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.189097e-09 | 8.496 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.170334e-09 | 8.144 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.028754e-09 | 8.095 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 9.881822e-09 | 8.005 |
| R-HSA-68886 | M Phase | 2.003638e-08 | 7.698 |
| R-HSA-68882 | Mitotic Anaphase | 1.846004e-08 | 7.734 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.961277e-08 | 7.707 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.179598e-08 | 7.662 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.942787e-08 | 7.531 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.187821e-08 | 7.378 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.286826e-08 | 7.277 |
| R-HSA-69275 | G2/M Transition | 1.067681e-07 | 6.972 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.207436e-07 | 6.918 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.130229e-07 | 6.672 |
| R-HSA-9646399 | Aggrephagy | 2.467613e-07 | 6.608 |
| R-HSA-983189 | Kinesins | 3.521366e-07 | 6.453 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.025006e-07 | 6.395 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.193214e-07 | 6.143 |
| R-HSA-437239 | Recycling pathway of L1 | 7.943727e-07 | 6.100 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 9.957296e-07 | 6.002 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.151426e-06 | 5.939 |
| R-HSA-190861 | Gap junction assembly | 1.382581e-06 | 5.859 |
| R-HSA-373760 | L1CAM interactions | 1.400873e-06 | 5.854 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.471270e-06 | 5.832 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.780956e-06 | 5.749 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.155294e-06 | 5.666 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.687220e-06 | 5.571 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.869982e-06 | 5.542 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.258178e-06 | 5.487 |
| R-HSA-190828 | Gap junction trafficking | 6.472966e-06 | 5.189 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.917811e-06 | 5.160 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.376341e-06 | 5.077 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 9.277203e-06 | 5.033 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.063668e-05 | 4.973 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.165568e-05 | 4.933 |
| R-HSA-180897 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabiliza... | 2.212283e-05 | 4.655 |
| R-HSA-5617833 | Cilium Assembly | 2.277577e-05 | 4.643 |
| R-HSA-9833482 | PKR-mediated signaling | 2.371563e-05 | 4.625 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.566522e-05 | 4.448 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.262337e-05 | 4.370 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.656372e-05 | 4.332 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.656372e-05 | 4.332 |
| R-HSA-9663891 | Selective autophagy | 4.681314e-05 | 4.330 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.156835e-05 | 4.211 |
| R-HSA-162582 | Signal Transduction | 6.480693e-05 | 4.188 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.088875e-05 | 4.149 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.954003e-05 | 4.048 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 9.013148e-05 | 4.045 |
| R-HSA-5620924 | Intraflagellar transport | 1.043089e-04 | 3.982 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.050633e-04 | 3.979 |
| R-HSA-447038 | NrCAM interactions | 1.152113e-04 | 3.939 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.180346e-04 | 3.928 |
| R-HSA-380287 | Centrosome maturation | 1.219480e-04 | 3.914 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 2.402341e-04 | 3.619 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.273804e-04 | 3.643 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.228846e-04 | 3.652 |
| R-HSA-1632852 | Macroautophagy | 2.562222e-04 | 3.591 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 3.264104e-04 | 3.486 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.521734e-04 | 3.453 |
| R-HSA-9612973 | Autophagy | 5.116383e-04 | 3.291 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.713618e-04 | 3.327 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.703443e-04 | 3.244 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 6.969147e-04 | 3.157 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 6.969147e-04 | 3.157 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.069147e-04 | 3.151 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 8.621853e-04 | 3.064 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.050412e-03 | 2.979 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.144745e-03 | 2.941 |
| R-HSA-422475 | Axon guidance | 1.267525e-03 | 2.897 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.556670e-03 | 2.808 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.556670e-03 | 2.808 |
| R-HSA-69242 | S Phase | 1.618497e-03 | 2.791 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.729206e-03 | 2.762 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.937242e-03 | 2.713 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 2.007912e-03 | 2.697 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.055182e-03 | 2.687 |
| R-HSA-391251 | Protein folding | 2.334617e-03 | 2.632 |
| R-HSA-9675108 | Nervous system development | 2.448600e-03 | 2.611 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.488333e-03 | 2.457 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.510086e-03 | 2.455 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.510086e-03 | 2.455 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.525478e-03 | 2.453 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.842177e-03 | 2.415 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 5.467792e-03 | 2.262 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 5.467792e-03 | 2.262 |
| R-HSA-69186 | Lagging Strand Synthesis | 4.928789e-03 | 2.307 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 5.010650e-03 | 2.300 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 5.467792e-03 | 2.262 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 4.928789e-03 | 2.307 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 6.040849e-03 | 2.219 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 6.287963e-03 | 2.201 |
| R-HSA-199991 | Membrane Trafficking | 6.797017e-03 | 2.168 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.445799e-03 | 2.128 |
| R-HSA-9609690 | HCMV Early Events | 7.529540e-03 | 2.123 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 7.697323e-03 | 2.114 |
| R-HSA-1221632 | Meiotic synapsis | 8.609256e-03 | 2.065 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 8.683862e-03 | 2.061 |
| R-HSA-9620244 | Long-term potentiation | 7.969560e-03 | 2.099 |
| R-HSA-3371556 | Cellular response to heat stress | 8.861337e-03 | 2.053 |
| R-HSA-1266738 | Developmental Biology | 8.022010e-03 | 2.096 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 9.235144e-03 | 2.035 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 9.434551e-03 | 2.025 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 9.434551e-03 | 2.025 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.541377e-03 | 2.020 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 1.022199e-02 | 1.990 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.179525e-02 | 1.928 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.180587e-02 | 1.928 |
| R-HSA-112316 | Neuronal System | 1.213757e-02 | 1.916 |
| R-HSA-5689877 | Josephin domain DUBs | 1.268218e-02 | 1.897 |
| R-HSA-69190 | DNA strand elongation | 1.374524e-02 | 1.862 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.409539e-02 | 1.851 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.660177e-02 | 1.780 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.712740e-02 | 1.766 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.472068e-02 | 1.832 |
| R-HSA-9733709 | Cardiogenesis | 1.472068e-02 | 1.832 |
| R-HSA-162906 | HIV Infection | 1.617971e-02 | 1.791 |
| R-HSA-913531 | Interferon Signaling | 1.731652e-02 | 1.762 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.330847e-02 | 1.632 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.331006e-02 | 1.632 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.353407e-02 | 1.628 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.523325e-02 | 1.598 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.523325e-02 | 1.598 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 2.562546e-02 | 1.591 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.575464e-02 | 1.589 |
| R-HSA-9609646 | HCMV Infection | 2.577011e-02 | 1.589 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.659485e-02 | 1.575 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.367189e-02 | 1.473 |
| R-HSA-169893 | Prolonged ERK activation events | 2.829843e-02 | 1.548 |
| R-HSA-1500620 | Meiosis | 3.392805e-02 | 1.469 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.392805e-02 | 1.469 |
| R-HSA-2028269 | Signaling by Hippo | 3.367189e-02 | 1.473 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.367189e-02 | 1.473 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.367189e-02 | 1.473 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.508745e-02 | 1.455 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.091118e-02 | 1.510 |
| R-HSA-5693538 | Homology Directed Repair | 2.985500e-02 | 1.525 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.943391e-02 | 1.531 |
| R-HSA-2262752 | Cellular responses to stress | 2.999363e-02 | 1.523 |
| R-HSA-109582 | Hemostasis | 3.423804e-02 | 1.465 |
| R-HSA-3928664 | Ephrin signaling | 3.649587e-02 | 1.438 |
| R-HSA-5358508 | Mismatch Repair | 3.649587e-02 | 1.438 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.720236e-02 | 1.429 |
| R-HSA-5687583 | Defective SLC34A2 causes PALM | 3.819204e-02 | 1.418 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 3.819204e-02 | 1.418 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 3.819204e-02 | 1.418 |
| R-HSA-5619045 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | 3.819204e-02 | 1.418 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 3.819204e-02 | 1.418 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 3.819204e-02 | 1.418 |
| R-HSA-9824446 | Viral Infection Pathways | 4.385660e-02 | 1.358 |
| R-HSA-9843745 | Adipogenesis | 4.394083e-02 | 1.357 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.409669e-02 | 1.356 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.864285e-02 | 1.313 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.052404e-02 | 1.297 |
| R-HSA-168277 | Influenza Virus Induced Apoptosis | 5.059731e-02 | 1.296 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 5.059731e-02 | 1.296 |
| R-HSA-177929 | Signaling by EGFR | 5.158025e-02 | 1.288 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 5.187922e-02 | 1.285 |
| R-HSA-8939211 | ESR-mediated signaling | 5.189766e-02 | 1.285 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.354126e-02 | 1.271 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 5.519036e-02 | 1.258 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.553773e-02 | 1.255 |
| R-HSA-180786 | Extension of Telomeres | 5.756937e-02 | 1.240 |
| R-HSA-73894 | DNA Repair | 6.145616e-02 | 1.211 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 7.493216e-02 | 1.125 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 7.649404e-02 | 1.116 |
| R-HSA-201451 | Signaling by BMP | 6.913454e-02 | 1.160 |
| R-HSA-427589 | Type II Na+/Pi cotransporters | 6.284334e-02 | 1.202 |
| R-HSA-69239 | Synthesis of DNA | 7.064213e-02 | 1.151 |
| R-HSA-525793 | Myogenesis | 6.554825e-02 | 1.183 |
| R-HSA-205025 | NADE modulates death signalling | 7.493216e-02 | 1.125 |
| R-HSA-180024 | DARPP-32 events | 7.649404e-02 | 1.116 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.404069e-02 | 1.194 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.299733e-02 | 1.081 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.299733e-02 | 1.081 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 6.913454e-02 | 1.160 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.504360e-02 | 1.187 |
| R-HSA-182971 | EGFR downregulation | 8.408829e-02 | 1.075 |
| R-HSA-399719 | Trafficking of AMPA receptors | 8.408829e-02 | 1.075 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 8.456757e-02 | 1.073 |
| R-HSA-74713 | IRS activation | 8.686577e-02 | 1.061 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 8.686577e-02 | 1.061 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 8.686577e-02 | 1.061 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 9.190056e-02 | 1.037 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 9.190056e-02 | 1.037 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.202783e-02 | 1.036 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 9.202783e-02 | 1.036 |
| R-HSA-390522 | Striated Muscle Contraction | 9.588342e-02 | 1.018 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 9.633981e-02 | 1.016 |
| R-HSA-9020591 | Interleukin-12 signaling | 9.714797e-02 | 1.013 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 9.864616e-02 | 1.006 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 9.864616e-02 | 1.006 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 9.864616e-02 | 1.006 |
| R-HSA-180746 | Nuclear import of Rev protein | 9.991483e-02 | 1.000 |
| R-HSA-73886 | Chromosome Maintenance | 1.003268e-01 | 0.999 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.023815e-01 | 0.990 |
| R-HSA-187687 | Signalling to ERKs | 1.039929e-01 | 0.983 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 1.102753e-01 | 0.958 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.102753e-01 | 0.958 |
| R-HSA-170984 | ARMS-mediated activation | 1.442743e-01 | 0.841 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.442743e-01 | 0.841 |
| R-HSA-164843 | 2-LTR circle formation | 1.553175e-01 | 0.809 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.662188e-01 | 0.779 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.662188e-01 | 0.779 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.662188e-01 | 0.779 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.662188e-01 | 0.779 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.769801e-01 | 0.752 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.876032e-01 | 0.727 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.876032e-01 | 0.727 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.876032e-01 | 0.727 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.876032e-01 | 0.727 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.876032e-01 | 0.727 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.876032e-01 | 0.727 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.980898e-01 | 0.703 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.084417e-01 | 0.681 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.186606e-01 | 0.660 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.186606e-01 | 0.660 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.186606e-01 | 0.660 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.387061e-01 | 0.622 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.250192e-01 | 0.903 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.250192e-01 | 0.903 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.772745e-01 | 0.557 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.866088e-01 | 0.543 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.741847e-01 | 0.759 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.021433e-01 | 0.694 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.772745e-01 | 0.557 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.772745e-01 | 0.557 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.788017e-01 | 0.748 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.387061e-01 | 0.622 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.592256e-01 | 0.586 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 2.287481e-01 | 0.641 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.165115e-01 | 0.500 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.632975e-01 | 0.787 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.678187e-01 | 0.572 |
| R-HSA-9694614 | Attachment and Entry | 2.958231e-01 | 0.529 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.330875e-01 | 0.876 |
| R-HSA-4839744 | Signaling by APC mutants | 1.662188e-01 | 0.779 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.769801e-01 | 0.752 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.769801e-01 | 0.752 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.980898e-01 | 0.703 |
| R-HSA-9678110 | Attachment and Entry | 2.287481e-01 | 0.641 |
| R-HSA-163615 | PKA activation | 2.582397e-01 | 0.588 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.582397e-01 | 0.588 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.227614e-01 | 0.491 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.582397e-01 | 0.588 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.687976e-01 | 0.571 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.664308e-01 | 0.779 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.250192e-01 | 0.903 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.553175e-01 | 0.809 |
| R-HSA-8963888 | Chylomicron assembly | 1.662188e-01 | 0.779 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.186606e-01 | 0.660 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.019542e-01 | 0.695 |
| R-HSA-69306 | DNA Replication | 1.836463e-01 | 0.736 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.293394e-01 | 0.888 |
| R-HSA-8964041 | LDL remodeling | 1.217551e-01 | 0.915 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.442743e-01 | 0.841 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.662188e-01 | 0.779 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.980898e-01 | 0.703 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.186606e-01 | 0.660 |
| R-HSA-1181150 | Signaling by NODAL | 2.772745e-01 | 0.557 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.772745e-01 | 0.557 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.068546e-01 | 0.684 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.442743e-01 | 0.841 |
| R-HSA-1502540 | Signaling by Activin | 2.186606e-01 | 0.660 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.207350e-01 | 0.918 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.077250e-01 | 0.968 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.102753e-01 | 0.958 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.485361e-01 | 0.605 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.866088e-01 | 0.543 |
| R-HSA-1268020 | Mitochondrial protein import | 2.305653e-01 | 0.637 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.305653e-01 | 0.637 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.958231e-01 | 0.529 |
| R-HSA-157579 | Telomere Maintenance | 1.664308e-01 | 0.779 |
| R-HSA-69091 | Polymerase switching | 1.876032e-01 | 0.727 |
| R-HSA-69109 | Leading Strand Synthesis | 1.876032e-01 | 0.727 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.876032e-01 | 0.727 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 1.876032e-01 | 0.727 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.186606e-01 | 0.660 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.678187e-01 | 0.572 |
| R-HSA-429947 | Deadenylation of mRNA | 3.227614e-01 | 0.491 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.227614e-01 | 0.491 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.880907e-01 | 0.726 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.353311e-01 | 0.628 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.052872e-01 | 0.688 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.783677e-01 | 0.555 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.927061e-01 | 0.534 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.442743e-01 | 0.841 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.876032e-01 | 0.727 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.980898e-01 | 0.703 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.607078e-01 | 0.794 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.514261e-01 | 0.820 |
| R-HSA-162592 | Integration of provirus | 1.769801e-01 | 0.752 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 2.866088e-01 | 0.543 |
| R-HSA-69481 | G2/M Checkpoints | 1.148678e-01 | 0.940 |
| R-HSA-8964011 | HDL clearance | 1.102753e-01 | 0.958 |
| R-HSA-8866423 | VLDL assembly | 1.102753e-01 | 0.958 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.662188e-01 | 0.779 |
| R-HSA-5682910 | LGI-ADAM interactions | 1.662188e-01 | 0.779 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.980898e-01 | 0.703 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.084417e-01 | 0.681 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.186606e-01 | 0.660 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.186606e-01 | 0.660 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.485361e-01 | 0.605 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.258061e-01 | 0.646 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.582397e-01 | 0.588 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.227614e-01 | 0.491 |
| R-HSA-170968 | Frs2-mediated activation | 1.980898e-01 | 0.703 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.727500e-01 | 0.763 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.336941e-01 | 0.874 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.842388e-01 | 0.546 |
| R-HSA-74749 | Signal attenuation | 1.553175e-01 | 0.809 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 1.876032e-01 | 0.727 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.678187e-01 | 0.572 |
| R-HSA-392517 | Rap1 signalling | 2.678187e-01 | 0.572 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.678187e-01 | 0.572 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.958231e-01 | 0.529 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 2.958231e-01 | 0.529 |
| R-HSA-1474165 | Reproduction | 1.235707e-01 | 0.908 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.293394e-01 | 0.888 |
| R-HSA-73884 | Base Excision Repair | 1.389227e-01 | 0.857 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.081157e-01 | 0.966 |
| R-HSA-8852135 | Protein ubiquitination | 2.927061e-01 | 0.534 |
| R-HSA-9707616 | Heme signaling | 2.305653e-01 | 0.637 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.831502e-01 | 0.548 |
| R-HSA-6806834 | Signaling by MET | 3.165115e-01 | 0.500 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.212528e-01 | 0.493 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.425151e-01 | 0.615 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.876032e-01 | 0.727 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.186606e-01 | 0.660 |
| R-HSA-166187 | Mitochondrial Uncoupling | 2.287481e-01 | 0.641 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.958231e-01 | 0.529 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.164885e-01 | 0.934 |
| R-HSA-597592 | Post-translational protein modification | 2.647999e-01 | 0.577 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.582397e-01 | 0.588 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.632705e-01 | 0.580 |
| R-HSA-9020933 | Interleukin-23 signaling | 1.330875e-01 | 0.876 |
| R-HSA-435354 | Zinc transporters | 2.084417e-01 | 0.681 |
| R-HSA-1280218 | Adaptive Immune System | 3.117792e-01 | 0.506 |
| R-HSA-373755 | Semaphorin interactions | 2.353311e-01 | 0.628 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.081157e-01 | 0.966 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.582397e-01 | 0.588 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.101121e-01 | 0.508 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.021433e-01 | 0.694 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.986658e-01 | 0.702 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.687976e-01 | 0.571 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.138979e-01 | 0.503 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.678187e-01 | 0.572 |
| R-HSA-162587 | HIV Life Cycle | 1.940403e-01 | 0.712 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.980898e-01 | 0.703 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.317612e-01 | 0.635 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.485361e-01 | 0.605 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.227614e-01 | 0.491 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.227614e-01 | 0.491 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.831501e-01 | 0.737 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.084417e-01 | 0.681 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.678187e-01 | 0.572 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.301284e-01 | 0.886 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.582397e-01 | 0.588 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.049190e-01 | 0.516 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.448785e-01 | 0.611 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.808350e-01 | 0.743 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 3.307109e-01 | 0.481 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.315109e-01 | 0.480 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.315109e-01 | 0.480 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.315109e-01 | 0.480 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.315109e-01 | 0.480 |
| R-HSA-9839394 | TGFBR3 expression | 3.315109e-01 | 0.480 |
| R-HSA-3214842 | HDMs demethylate histones | 3.315109e-01 | 0.480 |
| R-HSA-9679506 | SARS-CoV Infections | 3.333856e-01 | 0.477 |
| R-HSA-5357801 | Programmed Cell Death | 3.347804e-01 | 0.475 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.354265e-01 | 0.474 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.401324e-01 | 0.468 |
| R-HSA-3295583 | TRP channels | 3.401479e-01 | 0.468 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.401479e-01 | 0.468 |
| R-HSA-70635 | Urea cycle | 3.401479e-01 | 0.468 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.401479e-01 | 0.468 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.420941e-01 | 0.466 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.448281e-01 | 0.462 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.466749e-01 | 0.460 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.486738e-01 | 0.458 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.486738e-01 | 0.458 |
| R-HSA-264876 | Insulin processing | 3.486738e-01 | 0.458 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.495130e-01 | 0.457 |
| R-HSA-397014 | Muscle contraction | 3.552727e-01 | 0.449 |
| R-HSA-77387 | Insulin receptor recycling | 3.570901e-01 | 0.447 |
| R-HSA-5620971 | Pyroptosis | 3.570901e-01 | 0.447 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.570901e-01 | 0.447 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.582468e-01 | 0.446 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.588486e-01 | 0.445 |
| R-HSA-166520 | Signaling by NTRKs | 3.652774e-01 | 0.437 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.653982e-01 | 0.437 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.653982e-01 | 0.437 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.653982e-01 | 0.437 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.732273e-01 | 0.428 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.735994e-01 | 0.428 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.735994e-01 | 0.428 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.735994e-01 | 0.428 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.735994e-01 | 0.428 |
| R-HSA-5663205 | Infectious disease | 3.767108e-01 | 0.424 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.773697e-01 | 0.423 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.816951e-01 | 0.418 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.816951e-01 | 0.418 |
| R-HSA-186763 | Downstream signal transduction | 3.816951e-01 | 0.418 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.819661e-01 | 0.418 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.819661e-01 | 0.418 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.819661e-01 | 0.418 |
| R-HSA-9609507 | Protein localization | 3.827955e-01 | 0.417 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.862872e-01 | 0.413 |
| R-HSA-73887 | Death Receptor Signaling | 3.862872e-01 | 0.413 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.896867e-01 | 0.409 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.896867e-01 | 0.409 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.896867e-01 | 0.409 |
| R-HSA-9837999 | Mitochondrial protein degradation | 3.911154e-01 | 0.408 |
| R-HSA-1474290 | Collagen formation | 3.911154e-01 | 0.408 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.911453e-01 | 0.408 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.962095e-01 | 0.402 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.967339e-01 | 0.402 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.975755e-01 | 0.401 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.975755e-01 | 0.401 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.975755e-01 | 0.401 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.975755e-01 | 0.401 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.975755e-01 | 0.401 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.975755e-01 | 0.401 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.975755e-01 | 0.401 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.053628e-01 | 0.392 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.053628e-01 | 0.392 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 4.053628e-01 | 0.392 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 4.053628e-01 | 0.392 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.130499e-01 | 0.384 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.130499e-01 | 0.384 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.130499e-01 | 0.384 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.130499e-01 | 0.384 |
| R-HSA-109581 | Apoptosis | 4.140378e-01 | 0.383 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.181883e-01 | 0.379 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.194411e-01 | 0.377 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.206381e-01 | 0.376 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.206381e-01 | 0.376 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.206381e-01 | 0.376 |
| R-HSA-70171 | Glycolysis | 4.226421e-01 | 0.374 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 4.270785e-01 | 0.369 |
| R-HSA-3371511 | HSF1 activation | 4.281287e-01 | 0.368 |
| R-HSA-111933 | Calmodulin induced events | 4.281287e-01 | 0.368 |
| R-HSA-111997 | CaM pathway | 4.281287e-01 | 0.368 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.281287e-01 | 0.368 |
| R-HSA-5619102 | SLC transporter disorders | 4.311845e-01 | 0.365 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.314971e-01 | 0.365 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.355228e-01 | 0.361 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.355228e-01 | 0.361 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.355228e-01 | 0.361 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.355228e-01 | 0.361 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.355228e-01 | 0.361 |
| R-HSA-111885 | Opioid Signalling | 4.402798e-01 | 0.356 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 4.428219e-01 | 0.354 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.428219e-01 | 0.354 |
| R-HSA-8875878 | MET promotes cell motility | 4.428219e-01 | 0.354 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 4.428219e-01 | 0.354 |
| R-HSA-418555 | G alpha (s) signalling events | 4.481497e-01 | 0.349 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.489882e-01 | 0.348 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.500269e-01 | 0.347 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.500269e-01 | 0.347 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.500269e-01 | 0.347 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.500269e-01 | 0.347 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.500269e-01 | 0.347 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.571393e-01 | 0.340 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 4.571393e-01 | 0.340 |
| R-HSA-202433 | Generation of second messenger molecules | 4.571393e-01 | 0.340 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.576203e-01 | 0.339 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.576203e-01 | 0.339 |
| R-HSA-211000 | Gene Silencing by RNA | 4.576203e-01 | 0.339 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 4.591802e-01 | 0.338 |
| R-HSA-4839726 | Chromatin organization | 4.623899e-01 | 0.335 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.641601e-01 | 0.333 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.641601e-01 | 0.333 |
| R-HSA-202403 | TCR signaling | 4.704214e-01 | 0.328 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.710905e-01 | 0.327 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.710905e-01 | 0.327 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.710905e-01 | 0.327 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.779318e-01 | 0.321 |
| R-HSA-111996 | Ca-dependent events | 4.779318e-01 | 0.321 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.779318e-01 | 0.321 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.788550e-01 | 0.320 |
| R-HSA-212436 | Generic Transcription Pathway | 4.796632e-01 | 0.319 |
| R-HSA-73621 | Pyrimidine catabolism | 4.846849e-01 | 0.315 |
| R-HSA-8854214 | TBC/RABGAPs | 4.846849e-01 | 0.315 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.913511e-01 | 0.309 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.913511e-01 | 0.309 |
| R-HSA-69236 | G1 Phase | 4.913511e-01 | 0.309 |
| R-HSA-5683826 | Surfactant metabolism | 4.913511e-01 | 0.309 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.954747e-01 | 0.305 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.979315e-01 | 0.303 |
| R-HSA-774815 | Nucleosome assembly | 4.979315e-01 | 0.303 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.979315e-01 | 0.303 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.979315e-01 | 0.303 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.979315e-01 | 0.303 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.979315e-01 | 0.303 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.979315e-01 | 0.303 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.979315e-01 | 0.303 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.979315e-01 | 0.303 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.995771e-01 | 0.301 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.995771e-01 | 0.301 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.044272e-01 | 0.297 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.044272e-01 | 0.297 |
| R-HSA-75153 | Apoptotic execution phase | 5.044272e-01 | 0.297 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.044272e-01 | 0.297 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 5.044272e-01 | 0.297 |
| R-HSA-70326 | Glucose metabolism | 5.077178e-01 | 0.294 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.077178e-01 | 0.294 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.108392e-01 | 0.292 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.151163e-01 | 0.288 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.171686e-01 | 0.286 |
| R-HSA-9634597 | GPER1 signaling | 5.171686e-01 | 0.286 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.171686e-01 | 0.286 |
| R-HSA-70263 | Gluconeogenesis | 5.171686e-01 | 0.286 |
| R-HSA-425410 | Metal ion SLC transporters | 5.171686e-01 | 0.286 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 5.171686e-01 | 0.286 |
| R-HSA-68875 | Mitotic Prophase | 5.197669e-01 | 0.284 |
| R-HSA-73893 | DNA Damage Bypass | 5.234166e-01 | 0.281 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.356721e-01 | 0.271 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.356721e-01 | 0.271 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 5.356721e-01 | 0.271 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.416817e-01 | 0.266 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.416817e-01 | 0.266 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.416817e-01 | 0.266 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.416817e-01 | 0.266 |
| R-HSA-446728 | Cell junction organization | 5.419056e-01 | 0.266 |
| R-HSA-69206 | G1/S Transition | 5.432711e-01 | 0.265 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.432711e-01 | 0.265 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.432711e-01 | 0.265 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.432711e-01 | 0.265 |
| R-HSA-194138 | Signaling by VEGF | 5.432711e-01 | 0.265 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.476139e-01 | 0.262 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.476139e-01 | 0.262 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.511278e-01 | 0.259 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.561544e-01 | 0.255 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.592500e-01 | 0.252 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.649558e-01 | 0.248 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.649558e-01 | 0.248 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.649558e-01 | 0.248 |
| R-HSA-5578775 | Ion homeostasis | 5.649558e-01 | 0.248 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.649558e-01 | 0.248 |
| R-HSA-75893 | TNF signaling | 5.649558e-01 | 0.248 |
| R-HSA-1483166 | Synthesis of PA | 5.705882e-01 | 0.244 |
| R-HSA-392499 | Metabolism of proteins | 5.709901e-01 | 0.243 |
| R-HSA-9909396 | Circadian clock | 5.733528e-01 | 0.242 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.761480e-01 | 0.239 |
| R-HSA-191859 | snRNP Assembly | 5.816361e-01 | 0.235 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.816361e-01 | 0.235 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.816361e-01 | 0.235 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.816361e-01 | 0.235 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.870535e-01 | 0.231 |
| R-HSA-8873719 | RAB geranylgeranylation | 5.870535e-01 | 0.231 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.870535e-01 | 0.231 |
| R-HSA-6798695 | Neutrophil degranulation | 5.893105e-01 | 0.230 |
| R-HSA-163685 | Integration of energy metabolism | 5.914140e-01 | 0.228 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.924011e-01 | 0.227 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.924011e-01 | 0.227 |
| R-HSA-112043 | PLC beta mediated events | 5.924011e-01 | 0.227 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.976797e-01 | 0.224 |
| R-HSA-186797 | Signaling by PDGF | 5.976797e-01 | 0.224 |
| R-HSA-74160 | Gene expression (Transcription) | 6.004144e-01 | 0.222 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.019760e-01 | 0.220 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 6.028903e-01 | 0.220 |
| R-HSA-8848021 | Signaling by PTK6 | 6.028903e-01 | 0.220 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.028903e-01 | 0.220 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.028903e-01 | 0.220 |
| R-HSA-74751 | Insulin receptor signalling cascade | 6.080338e-01 | 0.216 |
| R-HSA-1234174 | Cellular response to hypoxia | 6.131109e-01 | 0.212 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.191214e-01 | 0.208 |
| R-HSA-112040 | G-protein mediated events | 6.230697e-01 | 0.205 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.230697e-01 | 0.205 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.259623e-01 | 0.203 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.279530e-01 | 0.202 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.279530e-01 | 0.202 |
| R-HSA-5218859 | Regulated Necrosis | 6.279530e-01 | 0.202 |
| R-HSA-1500931 | Cell-Cell communication | 6.362331e-01 | 0.196 |
| R-HSA-72312 | rRNA processing | 6.366905e-01 | 0.196 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.375315e-01 | 0.195 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.375315e-01 | 0.195 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.421668e-01 | 0.192 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.422283e-01 | 0.192 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.422283e-01 | 0.192 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.422283e-01 | 0.192 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.422283e-01 | 0.192 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.468646e-01 | 0.189 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.468646e-01 | 0.189 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.514410e-01 | 0.186 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.514410e-01 | 0.186 |
| R-HSA-382551 | Transport of small molecules | 6.539012e-01 | 0.184 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.559584e-01 | 0.183 |
| R-HSA-1989781 | PPARA activates gene expression | 6.579489e-01 | 0.182 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.604176e-01 | 0.180 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.671494e-01 | 0.176 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.691640e-01 | 0.174 |
| R-HSA-877300 | Interferon gamma signaling | 6.701717e-01 | 0.174 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.734528e-01 | 0.172 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.750011e-01 | 0.171 |
| R-HSA-9659379 | Sensory processing of sound | 6.776862e-01 | 0.169 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.776862e-01 | 0.169 |
| R-HSA-977225 | Amyloid fiber formation | 6.859900e-01 | 0.164 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.859900e-01 | 0.164 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.900616e-01 | 0.161 |
| R-HSA-5688426 | Deubiquitination | 6.941892e-01 | 0.159 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.980156e-01 | 0.156 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.980480e-01 | 0.156 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.019641e-01 | 0.154 |
| R-HSA-72306 | tRNA processing | 7.047342e-01 | 0.152 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.058296e-01 | 0.151 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.096452e-01 | 0.149 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.096452e-01 | 0.149 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.125162e-01 | 0.147 |
| R-HSA-70268 | Pyruvate metabolism | 7.134115e-01 | 0.147 |
| R-HSA-202424 | Downstream TCR signaling | 7.244213e-01 | 0.140 |
| R-HSA-168255 | Influenza Infection | 7.286434e-01 | 0.137 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.350100e-01 | 0.134 |
| R-HSA-449147 | Signaling by Interleukins | 7.366726e-01 | 0.133 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.384488e-01 | 0.132 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.387349e-01 | 0.132 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.451938e-01 | 0.128 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.508994e-01 | 0.124 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.517656e-01 | 0.124 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.517656e-01 | 0.124 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.549880e-01 | 0.122 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.581687e-01 | 0.120 |
| R-HSA-5368286 | Mitochondrial translation initiation | 7.581687e-01 | 0.120 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.581687e-01 | 0.120 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.581687e-01 | 0.120 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.581687e-01 | 0.120 |
| R-HSA-422356 | Regulation of insulin secretion | 7.581687e-01 | 0.120 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.602790e-01 | 0.119 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.674665e-01 | 0.115 |
| R-HSA-1483255 | PI Metabolism | 7.704860e-01 | 0.113 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.734665e-01 | 0.112 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.764084e-01 | 0.110 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.764084e-01 | 0.110 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.821787e-01 | 0.107 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.905575e-01 | 0.102 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.905575e-01 | 0.102 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.932785e-01 | 0.101 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.932785e-01 | 0.101 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.932785e-01 | 0.101 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.959643e-01 | 0.099 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.959643e-01 | 0.099 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.038152e-01 | 0.095 |
| R-HSA-168256 | Immune System | 8.059453e-01 | 0.094 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.088813e-01 | 0.092 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.113654e-01 | 0.091 |
| R-HSA-418990 | Adherens junctions interactions | 8.159371e-01 | 0.088 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.186263e-01 | 0.087 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.209843e-01 | 0.086 |
| R-HSA-8951664 | Neddylation | 8.213536e-01 | 0.085 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.233117e-01 | 0.084 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.233117e-01 | 0.084 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.278767e-01 | 0.082 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.301149e-01 | 0.081 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.301149e-01 | 0.081 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.323242e-01 | 0.080 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.345049e-01 | 0.079 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.408791e-01 | 0.075 |
| R-HSA-114608 | Platelet degranulation | 8.429490e-01 | 0.074 |
| R-HSA-8956319 | Nucleotide catabolism | 8.470089e-01 | 0.072 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.489994e-01 | 0.071 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.506063e-01 | 0.070 |
| R-HSA-5576891 | Cardiac conduction | 8.529036e-01 | 0.069 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.567073e-01 | 0.067 |
| R-HSA-5368287 | Mitochondrial translation | 8.675409e-01 | 0.062 |
| R-HSA-421270 | Cell-cell junction organization | 8.681479e-01 | 0.061 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.709678e-01 | 0.060 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.709678e-01 | 0.060 |
| R-HSA-9664407 | Parasite infection | 8.709678e-01 | 0.060 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.726480e-01 | 0.059 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.759434e-01 | 0.058 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.759434e-01 | 0.058 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.791539e-01 | 0.056 |
| R-HSA-1643685 | Disease | 8.838162e-01 | 0.054 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.853289e-01 | 0.053 |
| R-HSA-9758941 | Gastrulation | 8.868229e-01 | 0.052 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.882976e-01 | 0.051 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.897532e-01 | 0.051 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.911898e-01 | 0.050 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.953890e-01 | 0.048 |
| R-HSA-9610379 | HCMV Late Events | 8.980984e-01 | 0.047 |
| R-HSA-9711097 | Cellular response to starvation | 8.994268e-01 | 0.046 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.014277e-01 | 0.045 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.020322e-01 | 0.045 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.034786e-01 | 0.044 |
| R-HSA-9658195 | Leishmania infection | 9.034786e-01 | 0.044 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.044891e-01 | 0.044 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.152060e-01 | 0.038 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.163123e-01 | 0.038 |
| R-HSA-1483257 | Phospholipid metabolism | 9.167598e-01 | 0.038 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.167598e-01 | 0.038 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.174043e-01 | 0.037 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.184822e-01 | 0.037 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.184822e-01 | 0.037 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.184822e-01 | 0.037 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.184822e-01 | 0.037 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.184822e-01 | 0.037 |
| R-HSA-195721 | Signaling by WNT | 9.193742e-01 | 0.037 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.195460e-01 | 0.036 |
| R-HSA-983712 | Ion channel transport | 9.339411e-01 | 0.030 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.356557e-01 | 0.029 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.381450e-01 | 0.028 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.397510e-01 | 0.027 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.428397e-01 | 0.026 |
| R-HSA-1474244 | Extracellular matrix organization | 9.434754e-01 | 0.025 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.450522e-01 | 0.025 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.450522e-01 | 0.025 |
| R-HSA-72172 | mRNA Splicing | 9.464797e-01 | 0.024 |
| R-HSA-6805567 | Keratinization | 9.478703e-01 | 0.023 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.493134e-01 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 9.648912e-01 | 0.016 |
| R-HSA-8953854 | Metabolism of RNA | 9.682709e-01 | 0.014 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.684906e-01 | 0.014 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.730358e-01 | 0.012 |
| R-HSA-418594 | G alpha (i) signalling events | 9.759362e-01 | 0.011 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.787431e-01 | 0.009 |
| R-HSA-5668914 | Diseases of metabolism | 9.808183e-01 | 0.008 |
| R-HSA-168249 | Innate Immune System | 9.837758e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.860773e-01 | 0.006 |
| R-HSA-8957322 | Metabolism of steroids | 9.890360e-01 | 0.005 |
| R-HSA-388396 | GPCR downstream signalling | 9.928804e-01 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 9.969617e-01 | 0.001 |
| R-HSA-72766 | Translation | 9.973247e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.979646e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.999874e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.884 | 0.221 | 2 | 0.900 |
MOS |
0.870 | 0.184 | 1 | 0.861 |
CDC7 |
0.868 | 0.056 | 1 | 0.827 |
GCN2 |
0.868 | 0.000 | 2 | 0.862 |
CLK3 |
0.868 | 0.171 | 1 | 0.842 |
PIM3 |
0.868 | 0.103 | -3 | 0.801 |
DSTYK |
0.867 | 0.134 | 2 | 0.918 |
PRPK |
0.865 | -0.070 | -1 | 0.861 |
NLK |
0.864 | 0.101 | 1 | 0.829 |
NEK6 |
0.864 | 0.098 | -2 | 0.857 |
ULK2 |
0.864 | -0.029 | 2 | 0.843 |
NDR2 |
0.863 | 0.059 | -3 | 0.798 |
CAMK1B |
0.862 | 0.041 | -3 | 0.840 |
RAF1 |
0.862 | -0.012 | 1 | 0.835 |
CDKL1 |
0.861 | 0.076 | -3 | 0.783 |
MST4 |
0.861 | 0.148 | 2 | 0.921 |
PKN3 |
0.861 | 0.103 | -3 | 0.804 |
PRKD1 |
0.861 | 0.094 | -3 | 0.800 |
ERK5 |
0.861 | 0.094 | 1 | 0.813 |
KIS |
0.861 | 0.143 | 1 | 0.691 |
MLK1 |
0.860 | 0.125 | 2 | 0.891 |
CDKL5 |
0.860 | 0.099 | -3 | 0.777 |
PKN2 |
0.860 | 0.134 | -3 | 0.813 |
IKKB |
0.860 | -0.069 | -2 | 0.757 |
TGFBR2 |
0.860 | 0.067 | -2 | 0.822 |
TBK1 |
0.859 | -0.053 | 1 | 0.739 |
MTOR |
0.859 | -0.066 | 1 | 0.778 |
PKCD |
0.859 | 0.151 | 2 | 0.878 |
WNK1 |
0.859 | 0.098 | -2 | 0.848 |
NUAK2 |
0.859 | 0.086 | -3 | 0.801 |
NEK7 |
0.859 | 0.019 | -3 | 0.833 |
PDHK4 |
0.858 | -0.200 | 1 | 0.847 |
BMPR2 |
0.858 | -0.058 | -2 | 0.882 |
PRKD2 |
0.858 | 0.096 | -3 | 0.738 |
RSK2 |
0.858 | 0.080 | -3 | 0.742 |
MLK3 |
0.858 | 0.179 | 2 | 0.853 |
NIK |
0.858 | 0.087 | -3 | 0.861 |
CAMK2G |
0.857 | -0.036 | 2 | 0.826 |
PIM1 |
0.857 | 0.114 | -3 | 0.750 |
SRPK1 |
0.857 | 0.097 | -3 | 0.723 |
RIPK3 |
0.857 | 0.033 | 3 | 0.763 |
NDR1 |
0.857 | 0.020 | -3 | 0.805 |
PDHK1 |
0.856 | -0.116 | 1 | 0.824 |
SKMLCK |
0.855 | 0.055 | -2 | 0.835 |
ATR |
0.855 | -0.040 | 1 | 0.805 |
BCKDK |
0.855 | 0.036 | -1 | 0.885 |
CHAK2 |
0.855 | 0.023 | -1 | 0.869 |
IKKE |
0.855 | -0.076 | 1 | 0.734 |
GRK5 |
0.854 | -0.015 | -3 | 0.841 |
IRE1 |
0.854 | 0.092 | 1 | 0.824 |
HUNK |
0.853 | -0.021 | 2 | 0.827 |
MLK2 |
0.853 | 0.075 | 2 | 0.880 |
HIPK4 |
0.853 | 0.062 | 1 | 0.805 |
GRK1 |
0.853 | 0.147 | -2 | 0.862 |
NEK9 |
0.852 | 0.047 | 2 | 0.909 |
PKR |
0.852 | 0.227 | 1 | 0.861 |
PKCB |
0.852 | 0.172 | 2 | 0.848 |
CAMLCK |
0.852 | 0.000 | -2 | 0.824 |
RSK3 |
0.851 | 0.035 | -3 | 0.742 |
ULK1 |
0.851 | -0.113 | -3 | 0.832 |
P70S6KB |
0.851 | 0.048 | -3 | 0.774 |
AURC |
0.851 | 0.064 | -2 | 0.639 |
ANKRD3 |
0.850 | 0.072 | 1 | 0.845 |
PKCA |
0.850 | 0.174 | 2 | 0.845 |
P90RSK |
0.850 | 0.021 | -3 | 0.750 |
PKCG |
0.850 | 0.133 | 2 | 0.854 |
ICK |
0.849 | 0.035 | -3 | 0.812 |
MARK4 |
0.849 | -0.033 | 4 | 0.812 |
PKACG |
0.849 | 0.030 | -2 | 0.741 |
DAPK2 |
0.849 | -0.016 | -3 | 0.845 |
SRPK2 |
0.849 | 0.075 | -3 | 0.653 |
AMPKA1 |
0.849 | -0.006 | -3 | 0.822 |
TTBK2 |
0.848 | -0.001 | 2 | 0.814 |
WNK3 |
0.848 | -0.128 | 1 | 0.816 |
MAPKAPK3 |
0.848 | -0.009 | -3 | 0.757 |
IRE2 |
0.848 | 0.082 | 2 | 0.820 |
LATS2 |
0.848 | -0.012 | -5 | 0.778 |
BMPR1B |
0.848 | 0.165 | 1 | 0.782 |
IKKA |
0.848 | -0.024 | -2 | 0.748 |
CAMK2D |
0.847 | -0.033 | -3 | 0.823 |
MLK4 |
0.847 | 0.130 | 2 | 0.829 |
PKCZ |
0.846 | 0.129 | 2 | 0.884 |
PAK1 |
0.846 | 0.013 | -2 | 0.743 |
GRK6 |
0.846 | -0.004 | 1 | 0.813 |
RIPK1 |
0.846 | -0.051 | 1 | 0.826 |
TSSK2 |
0.846 | 0.010 | -5 | 0.882 |
MAPKAPK2 |
0.845 | 0.027 | -3 | 0.708 |
TSSK1 |
0.845 | 0.029 | -3 | 0.837 |
SRPK3 |
0.844 | 0.065 | -3 | 0.699 |
PRKD3 |
0.844 | 0.049 | -3 | 0.712 |
PLK1 |
0.844 | 0.023 | -2 | 0.804 |
NEK2 |
0.844 | 0.090 | 2 | 0.902 |
PKCH |
0.844 | 0.116 | 2 | 0.827 |
ALK4 |
0.844 | 0.050 | -2 | 0.843 |
DLK |
0.844 | -0.076 | 1 | 0.805 |
CDK8 |
0.843 | 0.018 | 1 | 0.654 |
FAM20C |
0.843 | 0.016 | 2 | 0.556 |
YSK4 |
0.843 | 0.064 | 1 | 0.765 |
MELK |
0.843 | 0.001 | -3 | 0.780 |
PAK3 |
0.843 | -0.035 | -2 | 0.742 |
MASTL |
0.843 | -0.235 | -2 | 0.817 |
PHKG1 |
0.842 | 0.049 | -3 | 0.794 |
LATS1 |
0.842 | 0.061 | -3 | 0.816 |
GRK4 |
0.842 | -0.031 | -2 | 0.872 |
NUAK1 |
0.842 | 0.000 | -3 | 0.762 |
GRK7 |
0.842 | 0.145 | 1 | 0.745 |
TGFBR1 |
0.842 | 0.069 | -2 | 0.825 |
AMPKA2 |
0.842 | -0.016 | -3 | 0.788 |
RSK4 |
0.841 | 0.073 | -3 | 0.698 |
CDK5 |
0.841 | 0.085 | 1 | 0.694 |
NIM1 |
0.840 | -0.102 | 3 | 0.791 |
CAMK2A |
0.840 | 0.035 | 2 | 0.801 |
MNK2 |
0.840 | -0.002 | -2 | 0.751 |
CAMK2B |
0.840 | 0.016 | 2 | 0.782 |
CAMK4 |
0.840 | -0.071 | -3 | 0.788 |
QIK |
0.839 | -0.047 | -3 | 0.806 |
CHAK1 |
0.839 | -0.016 | 2 | 0.836 |
CDK19 |
0.839 | 0.027 | 1 | 0.617 |
AURB |
0.839 | 0.020 | -2 | 0.633 |
PIM2 |
0.839 | 0.091 | -3 | 0.722 |
CDK1 |
0.839 | 0.075 | 1 | 0.636 |
PKACB |
0.839 | 0.051 | -2 | 0.657 |
PERK |
0.838 | 0.059 | -2 | 0.863 |
SGK3 |
0.838 | 0.068 | -3 | 0.737 |
ATM |
0.838 | -0.041 | 1 | 0.736 |
CAMK1G |
0.838 | 0.039 | -3 | 0.735 |
QSK |
0.837 | -0.006 | 4 | 0.791 |
DYRK2 |
0.837 | 0.027 | 1 | 0.703 |
MSK2 |
0.836 | -0.042 | -3 | 0.720 |
PKG2 |
0.836 | 0.034 | -2 | 0.666 |
CDK18 |
0.836 | 0.065 | 1 | 0.609 |
AKT2 |
0.836 | 0.053 | -3 | 0.655 |
MNK1 |
0.836 | 0.005 | -2 | 0.766 |
PRKX |
0.836 | 0.083 | -3 | 0.627 |
CDK13 |
0.835 | 0.023 | 1 | 0.650 |
JNK3 |
0.835 | 0.056 | 1 | 0.653 |
HRI |
0.835 | -0.008 | -2 | 0.857 |
SIK |
0.835 | -0.011 | -3 | 0.733 |
MYLK4 |
0.835 | -0.001 | -2 | 0.751 |
ALK2 |
0.835 | 0.061 | -2 | 0.845 |
ACVR2A |
0.835 | 0.047 | -2 | 0.812 |
TLK2 |
0.835 | -0.019 | 1 | 0.795 |
JNK2 |
0.835 | 0.069 | 1 | 0.618 |
PINK1 |
0.835 | -0.036 | 1 | 0.847 |
VRK2 |
0.834 | -0.147 | 1 | 0.856 |
PAK2 |
0.834 | -0.056 | -2 | 0.732 |
CDK7 |
0.834 | -0.002 | 1 | 0.673 |
MST3 |
0.834 | 0.175 | 2 | 0.917 |
PLK3 |
0.834 | -0.026 | 2 | 0.790 |
CLK4 |
0.834 | 0.022 | -3 | 0.736 |
ACVR2B |
0.834 | 0.042 | -2 | 0.824 |
MEK1 |
0.834 | -0.154 | 2 | 0.852 |
CLK1 |
0.833 | 0.045 | -3 | 0.712 |
ERK1 |
0.833 | 0.058 | 1 | 0.629 |
CHK1 |
0.833 | -0.026 | -3 | 0.811 |
P38A |
0.833 | 0.038 | 1 | 0.712 |
BRSK1 |
0.832 | -0.046 | -3 | 0.762 |
IRAK4 |
0.832 | 0.029 | 1 | 0.823 |
HIPK1 |
0.832 | 0.080 | 1 | 0.722 |
HIPK2 |
0.832 | 0.084 | 1 | 0.622 |
ERK7 |
0.832 | 0.261 | 2 | 0.748 |
MSK1 |
0.832 | -0.004 | -3 | 0.730 |
PKCT |
0.832 | 0.074 | 2 | 0.834 |
MEKK2 |
0.832 | 0.055 | 2 | 0.864 |
PAK6 |
0.832 | -0.023 | -2 | 0.660 |
NEK5 |
0.832 | 0.065 | 1 | 0.839 |
CDK2 |
0.831 | 0.024 | 1 | 0.708 |
BRSK2 |
0.831 | -0.079 | -3 | 0.792 |
ERK2 |
0.830 | 0.029 | 1 | 0.685 |
PKCI |
0.830 | 0.110 | 2 | 0.869 |
DRAK1 |
0.830 | -0.006 | 1 | 0.770 |
CLK2 |
0.830 | 0.087 | -3 | 0.714 |
MARK3 |
0.830 | -0.027 | 4 | 0.750 |
MEKK3 |
0.830 | -0.014 | 1 | 0.796 |
WNK4 |
0.830 | -0.014 | -2 | 0.837 |
BMPR1A |
0.830 | 0.101 | 1 | 0.750 |
MEKK1 |
0.829 | -0.008 | 1 | 0.793 |
CDK9 |
0.829 | 0.018 | 1 | 0.657 |
TLK1 |
0.829 | -0.011 | -2 | 0.855 |
GRK2 |
0.829 | 0.004 | -2 | 0.758 |
SMG1 |
0.829 | -0.102 | 1 | 0.757 |
P38B |
0.829 | 0.044 | 1 | 0.637 |
DCAMKL1 |
0.829 | -0.027 | -3 | 0.746 |
P38G |
0.829 | 0.053 | 1 | 0.544 |
ZAK |
0.828 | -0.021 | 1 | 0.742 |
BRAF |
0.828 | -0.042 | -4 | 0.792 |
CDK17 |
0.828 | 0.041 | 1 | 0.552 |
PLK4 |
0.828 | -0.095 | 2 | 0.662 |
MEK5 |
0.828 | -0.112 | 2 | 0.863 |
MARK2 |
0.827 | -0.057 | 4 | 0.707 |
CDK10 |
0.827 | 0.106 | 1 | 0.644 |
P70S6K |
0.827 | 0.019 | -3 | 0.694 |
SNRK |
0.827 | -0.163 | 2 | 0.719 |
CDK12 |
0.827 | 0.018 | 1 | 0.624 |
HIPK3 |
0.827 | 0.038 | 1 | 0.725 |
PRP4 |
0.827 | 0.049 | -3 | 0.788 |
TAO3 |
0.827 | 0.064 | 1 | 0.791 |
AURA |
0.827 | -0.023 | -2 | 0.600 |
NEK8 |
0.826 | 0.059 | 2 | 0.892 |
MAPKAPK5 |
0.826 | -0.114 | -3 | 0.718 |
PKCE |
0.826 | 0.119 | 2 | 0.841 |
MPSK1 |
0.826 | 0.082 | 1 | 0.806 |
SMMLCK |
0.825 | -0.002 | -3 | 0.795 |
AKT1 |
0.825 | 0.042 | -3 | 0.671 |
DYRK1A |
0.825 | 0.011 | 1 | 0.743 |
DNAPK |
0.825 | -0.052 | 1 | 0.685 |
CDK16 |
0.825 | 0.077 | 1 | 0.572 |
MARK1 |
0.824 | -0.066 | 4 | 0.771 |
CDK14 |
0.824 | 0.051 | 1 | 0.655 |
CDK3 |
0.824 | 0.067 | 1 | 0.571 |
CK1E |
0.824 | 0.013 | -3 | 0.483 |
PASK |
0.824 | 0.045 | -3 | 0.806 |
PHKG2 |
0.823 | -0.018 | -3 | 0.764 |
SSTK |
0.823 | -0.016 | 4 | 0.782 |
GSK3A |
0.823 | 0.097 | 4 | 0.491 |
PKACA |
0.823 | 0.021 | -2 | 0.611 |
DCAMKL2 |
0.823 | -0.034 | -3 | 0.773 |
GSK3B |
0.822 | 0.060 | 4 | 0.485 |
GAK |
0.822 | 0.100 | 1 | 0.845 |
CAMKK1 |
0.821 | -0.060 | -2 | 0.761 |
MST2 |
0.821 | 0.096 | 1 | 0.809 |
GCK |
0.821 | 0.148 | 1 | 0.820 |
TTBK1 |
0.820 | -0.078 | 2 | 0.731 |
TAO2 |
0.820 | 0.021 | 2 | 0.908 |
NEK11 |
0.820 | -0.032 | 1 | 0.791 |
MINK |
0.819 | 0.114 | 1 | 0.806 |
CAMK1D |
0.819 | -0.002 | -3 | 0.653 |
TNIK |
0.819 | 0.118 | 3 | 0.836 |
HGK |
0.819 | 0.080 | 3 | 0.846 |
NEK4 |
0.818 | 0.020 | 1 | 0.810 |
PKN1 |
0.818 | 0.054 | -3 | 0.704 |
DYRK1B |
0.818 | 0.011 | 1 | 0.675 |
LOK |
0.818 | 0.083 | -2 | 0.774 |
EEF2K |
0.817 | 0.086 | 3 | 0.823 |
P38D |
0.817 | 0.039 | 1 | 0.561 |
CAMKK2 |
0.817 | -0.058 | -2 | 0.756 |
AKT3 |
0.817 | 0.062 | -3 | 0.593 |
CK1D |
0.816 | 0.016 | -3 | 0.434 |
DYRK4 |
0.816 | 0.016 | 1 | 0.624 |
SLK |
0.816 | 0.076 | -2 | 0.735 |
LKB1 |
0.816 | -0.055 | -3 | 0.829 |
DYRK3 |
0.815 | 0.005 | 1 | 0.725 |
HPK1 |
0.815 | 0.104 | 1 | 0.811 |
LRRK2 |
0.815 | 0.041 | 2 | 0.913 |
DAPK3 |
0.814 | 0.001 | -3 | 0.762 |
CDK6 |
0.814 | 0.067 | 1 | 0.633 |
GRK3 |
0.814 | -0.002 | -2 | 0.729 |
MST1 |
0.813 | 0.066 | 1 | 0.799 |
PDK1 |
0.813 | -0.071 | 1 | 0.803 |
TAK1 |
0.813 | 0.046 | 1 | 0.811 |
CHK2 |
0.813 | 0.021 | -3 | 0.607 |
CK2A2 |
0.813 | 0.077 | 1 | 0.713 |
SGK1 |
0.813 | 0.050 | -3 | 0.583 |
MEKK6 |
0.812 | -0.028 | 1 | 0.782 |
BUB1 |
0.812 | 0.119 | -5 | 0.814 |
KHS1 |
0.812 | 0.117 | 1 | 0.801 |
CAMK1A |
0.812 | 0.024 | -3 | 0.624 |
CK1G1 |
0.812 | -0.056 | -3 | 0.485 |
KHS2 |
0.811 | 0.151 | 1 | 0.815 |
PAK5 |
0.811 | -0.073 | -2 | 0.608 |
ROCK2 |
0.811 | 0.063 | -3 | 0.757 |
STK33 |
0.811 | -0.054 | 2 | 0.715 |
MRCKB |
0.810 | 0.030 | -3 | 0.710 |
NEK1 |
0.810 | 0.003 | 1 | 0.813 |
IRAK1 |
0.810 | -0.245 | -1 | 0.770 |
CK1A2 |
0.809 | -0.021 | -3 | 0.431 |
YSK1 |
0.809 | 0.082 | 2 | 0.904 |
JNK1 |
0.809 | 0.012 | 1 | 0.604 |
MAK |
0.809 | 0.074 | -2 | 0.690 |
PAK4 |
0.809 | -0.060 | -2 | 0.610 |
MAP3K15 |
0.808 | -0.060 | 1 | 0.736 |
CDK4 |
0.807 | 0.035 | 1 | 0.611 |
MRCKA |
0.807 | 0.007 | -3 | 0.729 |
PLK2 |
0.807 | 0.006 | -3 | 0.795 |
DAPK1 |
0.806 | -0.015 | -3 | 0.743 |
MOK |
0.806 | 0.062 | 1 | 0.753 |
VRK1 |
0.805 | -0.109 | 2 | 0.861 |
TTK |
0.804 | 0.105 | -2 | 0.834 |
PBK |
0.804 | 0.021 | 1 | 0.778 |
CK2A1 |
0.802 | 0.062 | 1 | 0.695 |
DMPK1 |
0.801 | 0.047 | -3 | 0.720 |
MYO3B |
0.801 | 0.123 | 2 | 0.906 |
NEK3 |
0.801 | -0.061 | 1 | 0.756 |
OSR1 |
0.800 | 0.043 | 2 | 0.873 |
ROCK1 |
0.800 | 0.048 | -3 | 0.729 |
HASPIN |
0.799 | 0.061 | -1 | 0.707 |
SBK |
0.798 | -0.003 | -3 | 0.544 |
PDHK3_TYR |
0.797 | 0.124 | 4 | 0.875 |
MEK2 |
0.796 | -0.245 | 2 | 0.832 |
RIPK2 |
0.796 | -0.231 | 1 | 0.715 |
MYO3A |
0.795 | 0.060 | 1 | 0.816 |
PKG1 |
0.794 | -0.040 | -2 | 0.585 |
CRIK |
0.794 | 0.041 | -3 | 0.673 |
BIKE |
0.792 | 0.046 | 1 | 0.727 |
TESK1_TYR |
0.791 | 0.019 | 3 | 0.875 |
PDHK4_TYR |
0.789 | 0.039 | 2 | 0.876 |
LIMK2_TYR |
0.788 | 0.049 | -3 | 0.881 |
TAO1 |
0.788 | -0.024 | 1 | 0.725 |
MAP2K4_TYR |
0.787 | -0.068 | -1 | 0.875 |
BMPR2_TYR |
0.787 | 0.029 | -1 | 0.859 |
MAP2K6_TYR |
0.787 | -0.021 | -1 | 0.879 |
PKMYT1_TYR |
0.786 | -0.039 | 3 | 0.854 |
MAP2K7_TYR |
0.785 | -0.192 | 2 | 0.871 |
PDHK1_TYR |
0.783 | -0.058 | -1 | 0.886 |
EPHA6 |
0.783 | 0.064 | -1 | 0.879 |
PINK1_TYR |
0.782 | -0.128 | 1 | 0.830 |
YANK3 |
0.782 | -0.038 | 2 | 0.506 |
ASK1 |
0.781 | -0.166 | 1 | 0.716 |
EPHB4 |
0.780 | 0.051 | -1 | 0.876 |
ALPHAK3 |
0.780 | -0.092 | -1 | 0.770 |
CK1A |
0.779 | -0.008 | -3 | 0.341 |
LIMK1_TYR |
0.779 | -0.097 | 2 | 0.885 |
RET |
0.779 | -0.082 | 1 | 0.784 |
TXK |
0.777 | 0.121 | 1 | 0.808 |
ABL2 |
0.777 | 0.017 | -1 | 0.830 |
TYRO3 |
0.776 | -0.078 | 3 | 0.798 |
AAK1 |
0.776 | 0.075 | 1 | 0.631 |
ROS1 |
0.776 | -0.055 | 3 | 0.773 |
MST1R |
0.775 | -0.096 | 3 | 0.800 |
TYK2 |
0.775 | -0.148 | 1 | 0.782 |
FGR |
0.774 | -0.010 | 1 | 0.836 |
YES1 |
0.774 | 0.000 | -1 | 0.852 |
STLK3 |
0.773 | -0.167 | 1 | 0.724 |
ABL1 |
0.773 | -0.004 | -1 | 0.823 |
INSRR |
0.773 | -0.010 | 3 | 0.750 |
TNK2 |
0.773 | -0.002 | 3 | 0.742 |
CSF1R |
0.773 | -0.070 | 3 | 0.795 |
TNNI3K_TYR |
0.772 | 0.058 | 1 | 0.789 |
DDR1 |
0.771 | -0.135 | 4 | 0.787 |
JAK2 |
0.770 | -0.178 | 1 | 0.769 |
LCK |
0.770 | 0.030 | -1 | 0.816 |
ITK |
0.769 | -0.006 | -1 | 0.800 |
PDGFRB |
0.769 | -0.074 | 3 | 0.806 |
BLK |
0.768 | 0.052 | -1 | 0.830 |
HCK |
0.767 | -0.053 | -1 | 0.820 |
JAK3 |
0.767 | -0.132 | 1 | 0.754 |
EPHB1 |
0.767 | -0.029 | 1 | 0.800 |
EPHA4 |
0.767 | -0.025 | 2 | 0.783 |
KDR |
0.767 | -0.044 | 3 | 0.758 |
FER |
0.766 | -0.141 | 1 | 0.828 |
TEC |
0.766 | 0.012 | -1 | 0.764 |
TNK1 |
0.766 | -0.077 | 3 | 0.782 |
EPHB3 |
0.766 | -0.024 | -1 | 0.869 |
EPHB2 |
0.765 | -0.004 | -1 | 0.854 |
SRMS |
0.765 | -0.070 | 1 | 0.812 |
NEK10_TYR |
0.764 | -0.106 | 1 | 0.685 |
FLT3 |
0.764 | -0.110 | 3 | 0.799 |
JAK1 |
0.764 | -0.050 | 1 | 0.722 |
WEE1_TYR |
0.763 | -0.021 | -1 | 0.763 |
FGFR2 |
0.763 | -0.153 | 3 | 0.790 |
KIT |
0.762 | -0.125 | 3 | 0.800 |
ALK |
0.761 | -0.080 | 3 | 0.732 |
LTK |
0.761 | -0.074 | 3 | 0.753 |
PDGFRA |
0.761 | -0.153 | 3 | 0.805 |
MERTK |
0.761 | -0.082 | 3 | 0.769 |
AXL |
0.760 | -0.127 | 3 | 0.766 |
MET |
0.760 | -0.074 | 3 | 0.774 |
FYN |
0.759 | 0.027 | -1 | 0.791 |
BMX |
0.759 | -0.049 | -1 | 0.729 |
FGFR1 |
0.759 | -0.164 | 3 | 0.763 |
CK1G3 |
0.759 | -0.032 | -3 | 0.290 |
EPHA7 |
0.759 | -0.025 | 2 | 0.799 |
TEK |
0.758 | -0.188 | 3 | 0.742 |
BTK |
0.758 | -0.163 | -1 | 0.774 |
DDR2 |
0.757 | -0.013 | 3 | 0.736 |
FLT1 |
0.757 | -0.086 | -1 | 0.828 |
EPHA3 |
0.756 | -0.070 | 2 | 0.769 |
NTRK1 |
0.755 | -0.153 | -1 | 0.858 |
NTRK2 |
0.755 | -0.133 | 3 | 0.761 |
INSR |
0.755 | -0.105 | 3 | 0.719 |
PTK2B |
0.754 | -0.005 | -1 | 0.805 |
PTK6 |
0.754 | -0.197 | -1 | 0.735 |
FRK |
0.753 | -0.095 | -1 | 0.834 |
FLT4 |
0.753 | -0.136 | 3 | 0.759 |
LYN |
0.752 | -0.071 | 3 | 0.736 |
EPHA1 |
0.752 | -0.130 | 3 | 0.746 |
ERBB2 |
0.752 | -0.153 | 1 | 0.721 |
FGFR3 |
0.751 | -0.167 | 3 | 0.759 |
EPHA5 |
0.750 | -0.036 | 2 | 0.760 |
NTRK3 |
0.750 | -0.110 | -1 | 0.812 |
MATK |
0.749 | -0.114 | -1 | 0.764 |
YANK2 |
0.749 | -0.064 | 2 | 0.519 |
SRC |
0.749 | -0.037 | -1 | 0.801 |
PTK2 |
0.748 | 0.039 | -1 | 0.774 |
EPHA8 |
0.747 | -0.060 | -1 | 0.831 |
EGFR |
0.743 | -0.105 | 1 | 0.616 |
SYK |
0.742 | 0.012 | -1 | 0.759 |
MUSK |
0.740 | -0.115 | 1 | 0.628 |
FGFR4 |
0.738 | -0.132 | -1 | 0.781 |
CSK |
0.738 | -0.178 | 2 | 0.803 |
IGF1R |
0.737 | -0.138 | 3 | 0.672 |
EPHA2 |
0.735 | -0.094 | -1 | 0.788 |
CK1G2 |
0.735 | -0.042 | -3 | 0.392 |
ERBB4 |
0.732 | -0.067 | 1 | 0.643 |
ZAP70 |
0.721 | -0.041 | -1 | 0.693 |
FES |
0.718 | -0.174 | -1 | 0.714 |