Motif 75 (n=122)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYL6 | RPL17-C18orf32 | S142 | ochoa | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) | None |
| A4D2B0 | MBLAC1 | S61 | ochoa | Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) | Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}. |
| A6NI28 | ARHGAP42 | S811 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| H7BY64 | ZNF511-PRAP1 | S142 | ochoa | ZNF511-PRAP1 readthrough | None |
| O00418 | EEF2K | S627 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O15014 | ZNF609 | T76 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15297 | PPM1D | S85 | ochoa|psp | Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) | Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). {ECO:0000250|UniProtKB:Q9QZ67, ECO:0000269|PubMed:15870257, ECO:0000269|PubMed:16311512, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23242139}. |
| O43159 | RRP8 | S223 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O60610 | DIAPH1 | S1254 | ochoa | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| O60828 | PQBP1 | Y245 | ochoa | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| O75064 | DENND4B | S736 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| O75369 | FLNB | S1988 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1592 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S1756 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O95153 | TSPOAP1 | S1091 | ochoa | Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) | Required for synaptic transmission regulation (PubMed:33539324). It probably controls the recruitement of voltage-gated calcium channels to the presynaptic membrane, and modulates neurotransmitter release. {ECO:0000269|PubMed:33539324}. |
| O95359 | TACC2 | S97 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95613 | PCNT | T3282 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95785 | WIZ | S1517 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P07197 | NEFM | S680 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P18621 | RPL17 | S142 | ochoa | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P18825 | ADRA2C | S338 | ochoa | Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. |
| P19419 | ELK1 | S200 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P21333 | FLNA | S2033 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P27635 | RPL10 | S54 | ochoa | Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) | Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}. |
| P35869 | AHR | S727 | psp | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P43681 | CHRNA4 | S467 | psp | Neuronal acetylcholine receptor subunit alpha-4 | Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system (PubMed:16835356, PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (PubMed:27698419, PubMed:29720657, PubMed:38454578). Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (By similarity). {ECO:0000250|UniProtKB:O70174, ECO:0000269|PubMed:16835356, ECO:0000269|PubMed:22361591, ECO:0000269|PubMed:27698419, ECO:0000269|PubMed:29720657, ECO:0000269|PubMed:38454578}. |
| P46013 | MKI67 | S1131 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1253 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1983 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2105 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2223 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2344 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2466 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49815 | TSC2 | S960 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50479 | PDLIM4 | S165 | ochoa | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}. |
| P78559 | MAP1A | S2307 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q03060 | CREM | S271 | psp | cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER) | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}. |
| Q13233 | MAP3K1 | S250 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13469 | NFATC2 | S110 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13563 | PKD2 | S74 | ochoa | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q14160 | SCRIB | S1547 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14676 | MDC1 | S1669 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14686 | NCOA6 | S1721 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14807 | KIF22 | S412 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q15004 | PCLAF | S29 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15059 | BRD3 | S263 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15652 | JMJD1C | S284 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15751 | HERC1 | S2747 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q2M1K9 | ZNF423 | S1160 | ochoa | Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Q3KQU3 | MAP7D1 | S811 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3MIN7 | RGL3 | S52 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q49A88 | CCDC14 | S754 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
| Q4ZG55 | GREB1 | S1160 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
| Q5T0F9 | CC2D1B | S528 | ochoa | Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}. |
| Q5T2W1 | PDZK1 | S364 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). {ECO:0000250}. |
| Q5T5P2 | KIAA1217 | S1091 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T5P2 | KIAA1217 | S1111 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5VWN6 | TASOR2 | S1539 | ochoa | Protein TASOR 2 | None |
| Q6N043 | ZNF280D | S530 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6P1M3 | LLGL2 | S680 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6P3S6 | FBXO42 | S391 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PJF5 | RHBDF2 | S177 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q7KZI7 | MARK2 | S422 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L590 | MCM10 | S548 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z5J4 | RAI1 | S106 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z5J4 | RAI1 | S637 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86U38 | NOP9 | S58 | ochoa | Nucleolar protein 9 | None |
| Q8IWQ3 | BRSK2 | S393 | ochoa | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}. |
| Q8IZD4 | DCP1B | S566 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8N103 | TAGAP | S354 | ochoa | T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) | May function as a GTPase-activating protein and may play important roles during T-cell activation. {ECO:0000269|PubMed:15177553}. |
| Q8N137 | CNTROB | S62 | ochoa | Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}. |
| Q8N350 | CBARP | S378 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N3V7 | SYNPO | S525 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N3V7 | SYNPO | S890 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N684 | CPSF7 | S325 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NB15 | ZNF511 | S199 | ochoa | Zinc finger protein 511 | May be involved in transcriptional regulation. {ECO:0000305}. |
| Q8ND56 | LSM14A | S216 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDX1 | PSD4 | S443 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NI27 | THOC2 | S1393 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TAP8 | PPP1R35 | S47 | ochoa | Protein phosphatase 1 regulatory subunit 35 | During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}. |
| Q8TBP0 | TBC1D16 | S155 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TD16 | BICD2 | S606 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TEK3 | DOT1L | S1104 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q96DM3 | RMC1 | S329 | ochoa | Regulator of MON1-CCZ1 complex (Colon cancer-associated protein Mic1) (Mic-1) (WD repeat-containing protein 98) | Component of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). {ECO:0000269|PubMed:29038162}. |
| Q96F63 | CCDC97 | S29 | ochoa | Coiled-coil domain-containing protein 97 | May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. {ECO:0000269|PubMed:26344197}. |
| Q96KM6 | ZNF512B | S665 | ochoa | Zinc finger protein 512B | Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}. |
| Q99569 | PKP4 | S510 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q9BQI3 | EIF2AK1 | S41 | ochoa | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}. |
| Q9BTV7 | CABLES2 | S105 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9BUT9 | MCRIP2 | S61 | ochoa | MAPK regulated corepressor interacting protein 2 (Protein FAM195A) | None |
| Q9BWG6 | SCNM1 | S144 | ochoa | Sodium channel modifier 1 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}. |
| Q9BYX2 | TBC1D2 | S267 | ochoa | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}. |
| Q9C0C9 | UBE2O | S322 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9GZN2 | TGIF2 | S153 | ochoa | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}. |
| Q9GZR1 | SENP6 | S362 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9H1B7 | IRF2BPL | S547 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H211 | CDT1 | S411 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H6Z4 | RANBP3 | S219 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H7C4 | SYNC | S26 | ochoa | Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1) | Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. {ECO:0000250|UniProtKB:Q9EPM5}. |
| Q9H7P9 | PLEKHG2 | S911 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9HBE1 | PATZ1 | S249 | ochoa | POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein) | Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552). {ECO:0000269|PubMed:10713105, ECO:0000269|PubMed:25755280, ECO:0000269|PubMed:31875552}.; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. {ECO:0000269|PubMed:31060775}. |
| Q9HCC9 | ZFYVE28 | S334 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9NR19 | ACSS2 | S30 | ochoa | Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (PubMed:28552616). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (PubMed:28552616). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (PubMed:28552616). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity). {ECO:0000250|UniProtKB:Q9QXG4, ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429, ECO:0000269|PubMed:28552616}. |
| Q9NSC2 | SALL1 | S586 | ochoa | Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1) | Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. {ECO:0000250|UniProtKB:Q9ER74}. |
| Q9NUA8 | ZBTB40 | S214 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NX00 | TMEM160 | S48 | ochoa | Transmembrane protein 160 | None |
| Q9NZT2 | OGFR | S645 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P227 | ARHGAP23 | S554 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2F8 | SIPA1L2 | S1650 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UH73 | EBF1 | S567 | ochoa | Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor) | Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). {ECO:0000250|UniProtKB:Q07802, ECO:0000269|PubMed:27807034}.; FUNCTION: (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314). {ECO:0000269|PubMed:26819314, ECO:0000269|PubMed:28968461}. |
| Q9UHX1 | PUF60 | S112 | ochoa | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9UL51 | HCN2 | S868 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q9UPN4 | CEP131 | S381 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UQ35 | SRRM2 | S1179 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1188 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1621 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB3 | CTNND2 | S532 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y2U5 | MAP3K2 | S164 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y570 | PPME1 | S42 | ochoa | Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}. |
| Q9Y6K5 | OAS3 | S396 | ochoa | 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}. |
| Q13526 | PIN1 | S126 | Sugiyama | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q8NE63 | HIPK4 | S411 | Sugiyama | Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) | Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.037477 | 1.426 |
| R-HSA-1296061 | HCN channels | 0.044804 | 1.349 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.044804 | 1.349 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.059291 | 1.227 |
| R-HSA-629587 | Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | 0.066453 | 1.177 |
| R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors | 0.080615 | 1.094 |
| R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | 0.094564 | 1.024 |
| R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors | 0.108302 | 0.965 |
| R-HSA-181431 | Acetylcholine binding and downstream events | 0.121834 | 0.914 |
| R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors | 0.121834 | 0.914 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.186499 | 0.729 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.186499 | 0.729 |
| R-HSA-72187 | mRNA 3'-end processing | 0.077539 | 1.110 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.041840 | 1.378 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.042876 | 1.368 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.047148 | 1.327 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.234811 | 0.629 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.102979 | 0.987 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.102979 | 0.987 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.110269 | 0.958 |
| R-HSA-192823 | Viral mRNA Translation | 0.057492 | 1.240 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.063665 | 1.196 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.127776 | 0.894 |
| R-HSA-380287 | Centrosome maturation | 0.132893 | 0.876 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.169868 | 0.770 |
| R-HSA-1989781 | PPARA activates gene expression | 0.146992 | 0.833 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.222980 | 0.652 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.150567 | 0.822 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.173955 | 0.760 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.031372 | 1.503 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.175287 | 0.756 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.289849 | 0.538 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.289849 | 0.538 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.289849 | 0.538 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.070132 | 1.154 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.059291 | 1.227 |
| R-HSA-156902 | Peptide chain elongation | 0.038810 | 1.411 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.070132 | 1.154 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.285767 | 0.544 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.116198 | 0.935 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.257889 | 0.589 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.005466 | 2.262 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.048248 | 1.317 |
| R-HSA-72172 | mRNA Splicing | 0.245137 | 0.611 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.003924 | 2.406 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.064935 | 1.188 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.222263 | 0.653 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.222263 | 0.653 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.148290 | 0.829 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.048248 | 1.317 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.031372 | 1.503 |
| R-HSA-9843745 | Adipogenesis | 0.005632 | 2.249 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.135163 | 0.869 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.161220 | 0.793 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.192700 | 0.715 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.204961 | 0.688 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.098196 | 1.008 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.048248 | 1.317 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.080012 | 1.097 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.161220 | 0.793 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.009468 | 2.024 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.043925 | 1.357 |
| R-HSA-9620244 | Long-term potentiation | 0.211022 | 0.676 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.236291 | 0.627 |
| R-HSA-9707616 | Heme signaling | 0.016887 | 1.772 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.192700 | 0.715 |
| R-HSA-5617833 | Cilium Assembly | 0.215027 | 0.668 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.001369 | 2.864 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.008571 | 2.067 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.087616 | 1.057 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.108302 | 0.965 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.148290 | 0.829 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.180251 | 0.744 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.204961 | 0.688 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.217037 | 0.663 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.064935 | 1.188 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.156455 | 0.806 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.204961 | 0.688 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.240646 | 0.619 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.055107 | 1.259 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.257889 | 0.589 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.186499 | 0.729 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.198853 | 0.701 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.217037 | 0.663 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.058703 | 1.231 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.046943 | 1.328 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.101459 | 0.994 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.234811 | 0.629 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.257889 | 0.589 |
| R-HSA-8854214 | TBC/RABGAPs | 0.007247 | 2.140 |
| R-HSA-8983711 | OAS antiviral response | 0.006839 | 2.165 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.115094 | 0.939 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.115094 | 0.939 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.115094 | 0.939 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.078267 | 1.106 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.258826 | 0.587 |
| R-HSA-9909396 | Circadian clock | 0.027381 | 1.563 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.028706 | 1.542 |
| R-HSA-165159 | MTOR signalling | 0.056519 | 1.248 |
| R-HSA-390696 | Adrenoceptors | 0.080615 | 1.094 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.148290 | 0.829 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.078267 | 1.106 |
| R-HSA-69206 | G1/S Transition | 0.092692 | 1.033 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.246438 | 0.608 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.121834 | 0.914 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.198853 | 0.701 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.034613 | 1.461 |
| R-HSA-69275 | G2/M Transition | 0.207138 | 0.684 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.211074 | 0.676 |
| R-HSA-198753 | ERK/MAPK targets | 0.180251 | 0.744 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.146992 | 0.833 |
| R-HSA-9711097 | Cellular response to starvation | 0.152365 | 0.817 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.176331 | 0.754 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.120193 | 0.920 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.011494 | 1.940 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.121834 | 0.914 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.173955 | 0.760 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.192700 | 0.715 |
| R-HSA-71384 | Ethanol oxidation | 0.192700 | 0.715 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.132893 | 0.876 |
| R-HSA-8953854 | Metabolism of RNA | 0.208141 | 0.682 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.185818 | 0.731 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.018526 | 1.732 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.087616 | 1.057 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.115094 | 0.939 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.112943 | 0.947 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.135163 | 0.869 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.141684 | 0.849 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.131272 | 0.882 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.086536 | 1.063 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.031303 | 1.504 |
| R-HSA-8939211 | ESR-mediated signaling | 0.134785 | 0.870 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.163240 | 0.787 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.079662 | 1.099 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.258826 | 0.587 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.241080 | 0.618 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.191701 | 0.717 |
| R-HSA-1640170 | Cell Cycle | 0.194797 | 0.710 |
| R-HSA-913531 | Interferon Signaling | 0.197341 | 0.705 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.170237 | 0.769 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.021070 | 1.676 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.043251 | 1.364 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.257889 | 0.589 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.257889 | 0.589 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.043564 | 1.361 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.274743 | 0.561 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.211074 | 0.676 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.234811 | 0.629 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.163293 | 0.787 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.046908 | 1.329 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.198853 | 0.701 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.217037 | 0.663 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.269167 | 0.570 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.199984 | 0.699 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.153798 | 0.813 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.197218 | 0.705 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.285767 | 0.544 |
| R-HSA-168255 | Influenza Infection | 0.193503 | 0.713 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.233480 | 0.632 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.241080 | 0.618 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.257889 | 0.589 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.202755 | 0.693 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.202755 | 0.693 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.202755 | 0.693 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.236291 | 0.627 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.270112 | 0.568 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.270112 | 0.568 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.278574 | 0.555 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.278574 | 0.555 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.247549 | 0.606 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.256006 | 0.592 |
| R-HSA-9830369 | Kidney development | 0.112729 | 0.948 |
| R-HSA-69481 | G2/M Checkpoints | 0.295479 | 0.529 |
| R-HSA-9646399 | Aggrephagy | 0.301993 | 0.520 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.301993 | 0.520 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.301993 | 0.520 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.301993 | 0.520 |
| R-HSA-72312 | rRNA processing | 0.302828 | 0.519 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.307320 | 0.512 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.307320 | 0.512 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.312330 | 0.505 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.312607 | 0.505 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.314267 | 0.503 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.328228 | 0.484 |
| R-HSA-5683826 | Surfactant metabolism | 0.328228 | 0.484 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.333356 | 0.477 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.333356 | 0.477 |
| R-HSA-1632852 | Macroautophagy | 0.340216 | 0.468 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.348509 | 0.458 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.348509 | 0.458 |
| R-HSA-73893 | DNA Damage Bypass | 0.353484 | 0.452 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.353484 | 0.452 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.362279 | 0.441 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.367754 | 0.434 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.368183 | 0.434 |
| R-HSA-69306 | DNA Replication | 0.375933 | 0.425 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.378649 | 0.422 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.382551 | 0.417 |
| R-HSA-418597 | G alpha (z) signalling events | 0.382551 | 0.417 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.382551 | 0.417 |
| R-HSA-9612973 | Autophagy | 0.384068 | 0.416 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.387268 | 0.412 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.389467 | 0.410 |
| R-HSA-877300 | Interferon gamma signaling | 0.392159 | 0.407 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.394845 | 0.404 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.396594 | 0.402 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.401205 | 0.397 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.401205 | 0.397 |
| R-HSA-199991 | Membrane Trafficking | 0.403728 | 0.394 |
| R-HSA-983189 | Kinesins | 0.405780 | 0.392 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.405780 | 0.392 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.405780 | 0.392 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.405780 | 0.392 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.405780 | 0.392 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.405780 | 0.392 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.405780 | 0.392 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.405780 | 0.392 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.405780 | 0.392 |
| R-HSA-211976 | Endogenous sterols | 0.410321 | 0.387 |
| R-HSA-450294 | MAP kinase activation | 0.410321 | 0.387 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.419300 | 0.377 |
| R-HSA-211981 | Xenobiotics | 0.423738 | 0.373 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.426649 | 0.370 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.436852 | 0.360 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.436852 | 0.360 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.449670 | 0.347 |
| R-HSA-448424 | Interleukin-17 signaling | 0.449670 | 0.347 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.453878 | 0.343 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.458054 | 0.339 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.462199 | 0.335 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.462199 | 0.335 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.462199 | 0.335 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.466312 | 0.331 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.466312 | 0.331 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.474444 | 0.324 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.477655 | 0.321 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.478464 | 0.320 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.482454 | 0.317 |
| R-HSA-4086400 | PCP/CE pathway | 0.482454 | 0.317 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.482454 | 0.317 |
| R-HSA-68877 | Mitotic Prometaphase | 0.482605 | 0.316 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.486413 | 0.313 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.488234 | 0.311 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.488234 | 0.311 |
| R-HSA-9609690 | HCMV Early Events | 0.489977 | 0.310 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.490342 | 0.310 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.490342 | 0.310 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.494242 | 0.306 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.498112 | 0.303 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.499705 | 0.301 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.513300 | 0.290 |
| R-HSA-112316 | Neuronal System | 0.515508 | 0.288 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.517025 | 0.286 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.520722 | 0.283 |
| R-HSA-9663891 | Selective autophagy | 0.524391 | 0.280 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.530496 | 0.275 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.531645 | 0.274 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.532811 | 0.273 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.535231 | 0.271 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.545826 | 0.263 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.559581 | 0.252 |
| R-HSA-1296071 | Potassium Channels | 0.559581 | 0.252 |
| R-HSA-422356 | Regulation of insulin secretion | 0.566303 | 0.247 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.569625 | 0.244 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.576195 | 0.239 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.579442 | 0.237 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.579632 | 0.237 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.592187 | 0.228 |
| R-HSA-68886 | M Phase | 0.597092 | 0.224 |
| R-HSA-69239 | Synthesis of DNA | 0.598415 | 0.223 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.607581 | 0.216 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.607581 | 0.216 |
| R-HSA-4839726 | Chromatin organization | 0.610939 | 0.214 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.611427 | 0.214 |
| R-HSA-9609646 | HCMV Infection | 0.612962 | 0.213 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.613575 | 0.212 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.619479 | 0.208 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.625294 | 0.204 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.628864 | 0.201 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.636659 | 0.196 |
| R-HSA-5693538 | Homology Directed Repair | 0.636659 | 0.196 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.639447 | 0.194 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.648029 | 0.188 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.650387 | 0.187 |
| R-HSA-162582 | Signal Transduction | 0.652273 | 0.186 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.653070 | 0.185 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.659151 | 0.181 |
| R-HSA-114608 | Platelet degranulation | 0.663600 | 0.178 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.666182 | 0.176 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.666410 | 0.176 |
| R-HSA-446728 | Cell junction organization | 0.666410 | 0.176 |
| R-HSA-72766 | Translation | 0.671258 | 0.173 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.673545 | 0.172 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.681269 | 0.167 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.685736 | 0.164 |
| R-HSA-2262752 | Cellular responses to stress | 0.686810 | 0.163 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.690950 | 0.161 |
| R-HSA-163685 | Integration of energy metabolism | 0.690950 | 0.161 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.697555 | 0.156 |
| R-HSA-69242 | S Phase | 0.720441 | 0.142 |
| R-HSA-166520 | Signaling by NTRKs | 0.720441 | 0.142 |
| R-HSA-1500931 | Cell-Cell communication | 0.729325 | 0.137 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.731026 | 0.136 |
| R-HSA-73887 | Death Receptor Signaling | 0.733094 | 0.135 |
| R-HSA-8957322 | Metabolism of steroids | 0.741227 | 0.130 |
| R-HSA-109582 | Hemostasis | 0.741377 | 0.130 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.745179 | 0.128 |
| R-HSA-1266738 | Developmental Biology | 0.751388 | 0.124 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.758593 | 0.120 |
| R-HSA-74160 | Gene expression (Transcription) | 0.765474 | 0.116 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.771306 | 0.113 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.771306 | 0.113 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.771306 | 0.113 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.771306 | 0.113 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.771427 | 0.113 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.772999 | 0.112 |
| R-HSA-73894 | DNA Repair | 0.789424 | 0.103 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.794767 | 0.100 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.808583 | 0.092 |
| R-HSA-422475 | Axon guidance | 0.810672 | 0.091 |
| R-HSA-428157 | Sphingolipid metabolism | 0.815852 | 0.088 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.817036 | 0.088 |
| R-HSA-6805567 | Keratinization | 0.824214 | 0.084 |
| R-HSA-68882 | Mitotic Anaphase | 0.837322 | 0.077 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.838579 | 0.076 |
| R-HSA-418990 | Adherens junctions interactions | 0.839825 | 0.076 |
| R-HSA-9675108 | Nervous system development | 0.843221 | 0.074 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.849194 | 0.071 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.849460 | 0.071 |
| R-HSA-212436 | Generic Transcription Pathway | 0.859207 | 0.066 |
| R-HSA-157118 | Signaling by NOTCH | 0.864958 | 0.063 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.866687 | 0.062 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.870171 | 0.060 |
| R-HSA-421270 | Cell-cell junction organization | 0.876016 | 0.057 |
| R-HSA-6798695 | Neutrophil degranulation | 0.882998 | 0.054 |
| R-HSA-168249 | Innate Immune System | 0.898558 | 0.046 |
| R-HSA-9658195 | Leishmania infection | 0.901814 | 0.045 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.901814 | 0.045 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.911956 | 0.040 |
| R-HSA-195721 | Signaling by WNT | 0.913990 | 0.039 |
| R-HSA-1280218 | Adaptive Immune System | 0.916018 | 0.038 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.918605 | 0.037 |
| R-HSA-211859 | Biological oxidations | 0.922637 | 0.035 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.938985 | 0.027 |
| R-HSA-9824446 | Viral Infection Pathways | 0.943243 | 0.025 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.959703 | 0.018 |
| R-HSA-418594 | G alpha (i) signalling events | 0.963609 | 0.016 |
| R-HSA-168256 | Immune System | 0.974167 | 0.011 |
| R-HSA-388396 | GPCR downstream signalling | 0.985413 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 0.991348 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 0.991813 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.991870 | 0.004 |
| R-HSA-5663205 | Infectious disease | 0.992478 | 0.003 |
| R-HSA-449147 | Signaling by Interleukins | 0.993501 | 0.003 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.998292 | 0.001 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999059 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999955 | 0.000 |
| R-HSA-1643685 | Disease | 0.999979 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999980 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999998 | 0.000 |
| R-HSA-597592 | Post-translational protein modification | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.850 | 0.800 | 1 | 0.848 |
HIPK2 |
0.833 | 0.729 | 1 | 0.894 |
DYRK4 |
0.821 | 0.724 | 1 | 0.903 |
P38D |
0.820 | 0.754 | 1 | 0.919 |
CDK18 |
0.820 | 0.719 | 1 | 0.888 |
DYRK2 |
0.819 | 0.715 | 1 | 0.834 |
P38G |
0.818 | 0.732 | 1 | 0.908 |
CDK19 |
0.818 | 0.712 | 1 | 0.879 |
CDK17 |
0.814 | 0.716 | 1 | 0.903 |
CDK3 |
0.814 | 0.597 | 1 | 0.903 |
HIPK4 |
0.814 | 0.581 | 1 | 0.655 |
CLK3 |
0.813 | 0.495 | 1 | 0.624 |
CDK8 |
0.812 | 0.698 | 1 | 0.856 |
CDK1 |
0.812 | 0.663 | 1 | 0.876 |
JNK2 |
0.810 | 0.721 | 1 | 0.883 |
HIPK1 |
0.809 | 0.654 | 1 | 0.818 |
CDK13 |
0.808 | 0.689 | 1 | 0.877 |
CDK7 |
0.806 | 0.676 | 1 | 0.863 |
DYRK1B |
0.806 | 0.671 | 1 | 0.868 |
CDK12 |
0.806 | 0.688 | 1 | 0.889 |
P38B |
0.806 | 0.707 | 1 | 0.857 |
ERK1 |
0.806 | 0.693 | 1 | 0.865 |
CDK16 |
0.804 | 0.676 | 1 | 0.896 |
CDK5 |
0.802 | 0.630 | 1 | 0.841 |
JNK3 |
0.802 | 0.698 | 1 | 0.873 |
CDK9 |
0.801 | 0.683 | 1 | 0.871 |
CLK2 |
0.800 | 0.416 | -3 | 0.734 |
SRPK1 |
0.798 | 0.339 | -3 | 0.747 |
P38A |
0.797 | 0.682 | 1 | 0.808 |
CDK10 |
0.797 | 0.632 | 1 | 0.872 |
HIPK3 |
0.795 | 0.639 | 1 | 0.782 |
CDK14 |
0.794 | 0.666 | 1 | 0.858 |
CLK1 |
0.789 | 0.411 | -3 | 0.708 |
DYRK1A |
0.789 | 0.545 | 1 | 0.794 |
NLK |
0.789 | 0.599 | 1 | 0.647 |
JNK1 |
0.788 | 0.630 | 1 | 0.885 |
ERK2 |
0.788 | 0.666 | 1 | 0.835 |
CLK4 |
0.787 | 0.387 | -3 | 0.737 |
DYRK3 |
0.787 | 0.509 | 1 | 0.791 |
SRPK2 |
0.786 | 0.274 | -3 | 0.664 |
CDK6 |
0.780 | 0.620 | 1 | 0.871 |
CDK4 |
0.780 | 0.644 | 1 | 0.894 |
CDK2 |
0.779 | 0.481 | 1 | 0.776 |
ERK5 |
0.778 | 0.346 | 1 | 0.555 |
PRP4 |
0.778 | 0.500 | -3 | 0.805 |
SRPK3 |
0.776 | 0.238 | -3 | 0.725 |
COT |
0.770 | -0.058 | 2 | 0.781 |
MTOR |
0.769 | 0.186 | 1 | 0.444 |
MOS |
0.765 | 0.056 | 1 | 0.369 |
ICK |
0.764 | 0.291 | -3 | 0.817 |
MAK |
0.764 | 0.409 | -2 | 0.705 |
CDKL5 |
0.762 | 0.137 | -3 | 0.771 |
CDKL1 |
0.761 | 0.121 | -3 | 0.785 |
CDC7 |
0.761 | -0.057 | 1 | 0.321 |
GCN2 |
0.758 | -0.036 | 2 | 0.688 |
PRPK |
0.756 | -0.047 | -1 | 0.770 |
CHAK2 |
0.756 | 0.003 | -1 | 0.800 |
MOK |
0.755 | 0.387 | 1 | 0.720 |
PRKD1 |
0.755 | 0.095 | -3 | 0.797 |
PIM3 |
0.754 | -0.026 | -3 | 0.827 |
PRKD2 |
0.753 | 0.095 | -3 | 0.741 |
TBK1 |
0.753 | -0.098 | 1 | 0.238 |
ATR |
0.753 | -0.019 | 1 | 0.338 |
IKKE |
0.753 | -0.094 | 1 | 0.237 |
DSTYK |
0.753 | -0.092 | 2 | 0.804 |
NDR2 |
0.752 | -0.004 | -3 | 0.823 |
IKKB |
0.752 | -0.107 | -2 | 0.732 |
BMPR1B |
0.752 | 0.030 | 1 | 0.279 |
ERK7 |
0.751 | 0.222 | 2 | 0.494 |
BMPR2 |
0.751 | -0.037 | -2 | 0.876 |
TGFBR2 |
0.750 | -0.024 | -2 | 0.849 |
NUAK2 |
0.750 | 0.001 | -3 | 0.811 |
SKMLCK |
0.750 | -0.021 | -2 | 0.854 |
NEK6 |
0.750 | -0.029 | -2 | 0.877 |
RAF1 |
0.750 | -0.139 | 1 | 0.288 |
CAMK1B |
0.750 | -0.029 | -3 | 0.821 |
GRK1 |
0.748 | -0.012 | -2 | 0.767 |
AURC |
0.747 | 0.053 | -2 | 0.630 |
RSK2 |
0.747 | 0.003 | -3 | 0.742 |
MST4 |
0.747 | -0.048 | 2 | 0.771 |
NDR1 |
0.746 | -0.041 | -3 | 0.804 |
ULK2 |
0.746 | -0.158 | 2 | 0.677 |
CAMLCK |
0.746 | -0.002 | -2 | 0.828 |
WNK1 |
0.746 | -0.071 | -2 | 0.859 |
PDHK4 |
0.746 | -0.169 | 1 | 0.353 |
P90RSK |
0.745 | 0.002 | -3 | 0.752 |
RSK3 |
0.745 | -0.002 | -3 | 0.744 |
NIK |
0.745 | -0.050 | -3 | 0.843 |
PIM1 |
0.744 | 0.015 | -3 | 0.765 |
PKN3 |
0.744 | -0.057 | -3 | 0.804 |
NEK7 |
0.744 | -0.140 | -3 | 0.830 |
PKCD |
0.743 | -0.035 | 2 | 0.696 |
HUNK |
0.742 | -0.137 | 2 | 0.737 |
RIPK3 |
0.742 | -0.161 | 3 | 0.428 |
MAPKAPK3 |
0.742 | 0.008 | -3 | 0.745 |
PKN2 |
0.742 | -0.074 | -3 | 0.808 |
TGFBR1 |
0.741 | 0.014 | -2 | 0.841 |
GRK7 |
0.741 | 0.005 | 1 | 0.300 |
PDHK1 |
0.741 | -0.149 | 1 | 0.330 |
MLK1 |
0.741 | -0.150 | 2 | 0.729 |
IKKA |
0.741 | -0.058 | -2 | 0.723 |
CAMK2G |
0.741 | -0.122 | 2 | 0.693 |
GRK5 |
0.740 | -0.122 | -3 | 0.843 |
DAPK2 |
0.740 | -0.030 | -3 | 0.830 |
P70S6KB |
0.740 | -0.002 | -3 | 0.759 |
MAPKAPK2 |
0.739 | 0.005 | -3 | 0.710 |
ALK4 |
0.738 | -0.005 | -2 | 0.858 |
MARK4 |
0.738 | -0.096 | 4 | 0.801 |
PKACG |
0.738 | -0.024 | -2 | 0.704 |
ACVR2B |
0.737 | -0.006 | -2 | 0.845 |
MLK3 |
0.737 | -0.069 | 2 | 0.669 |
MLK2 |
0.737 | -0.091 | 2 | 0.731 |
IRE1 |
0.737 | -0.104 | 1 | 0.298 |
ULK1 |
0.737 | -0.142 | -3 | 0.789 |
NEK9 |
0.737 | -0.129 | 2 | 0.728 |
PRKD3 |
0.736 | 0.030 | -3 | 0.716 |
PKACB |
0.736 | 0.035 | -2 | 0.645 |
PINK1 |
0.735 | 0.149 | 1 | 0.493 |
AMPKA1 |
0.735 | -0.095 | -3 | 0.817 |
LATS2 |
0.734 | -0.047 | -5 | 0.772 |
PKR |
0.734 | -0.049 | 1 | 0.323 |
PKCA |
0.734 | -0.029 | 2 | 0.655 |
PKCB |
0.734 | -0.041 | 2 | 0.656 |
GRK6 |
0.734 | -0.134 | 1 | 0.292 |
ACVR2A |
0.734 | -0.023 | -2 | 0.836 |
LATS1 |
0.734 | 0.006 | -3 | 0.831 |
PHKG1 |
0.734 | -0.047 | -3 | 0.793 |
PAK1 |
0.734 | -0.035 | -2 | 0.747 |
ATM |
0.734 | -0.071 | 1 | 0.300 |
SMG1 |
0.733 | -0.037 | 1 | 0.316 |
BMPR1A |
0.733 | -0.003 | 1 | 0.271 |
MNK2 |
0.733 | -0.026 | -2 | 0.765 |
FAM20C |
0.733 | -0.028 | 2 | 0.571 |
DNAPK |
0.732 | -0.032 | 1 | 0.288 |
ALK2 |
0.732 | -0.015 | -2 | 0.847 |
DLK |
0.732 | -0.167 | 1 | 0.296 |
NIM1 |
0.732 | -0.106 | 3 | 0.461 |
PKCG |
0.732 | -0.055 | 2 | 0.667 |
ANKRD3 |
0.732 | -0.160 | 1 | 0.306 |
GRK4 |
0.732 | -0.125 | -2 | 0.822 |
BCKDK |
0.732 | -0.150 | -1 | 0.698 |
RSK4 |
0.732 | -0.005 | -3 | 0.725 |
GSK3A |
0.731 | 0.139 | 4 | 0.376 |
RIPK1 |
0.731 | -0.196 | 1 | 0.286 |
TTBK2 |
0.731 | -0.176 | 2 | 0.597 |
PKCZ |
0.731 | -0.050 | 2 | 0.691 |
PAK3 |
0.731 | -0.054 | -2 | 0.748 |
TLK2 |
0.731 | -0.033 | 1 | 0.275 |
AMPKA2 |
0.731 | -0.072 | -3 | 0.785 |
MASTL |
0.731 | -0.192 | -2 | 0.799 |
VRK2 |
0.731 | -0.008 | 1 | 0.402 |
AKT2 |
0.730 | 0.026 | -3 | 0.666 |
CAMK2D |
0.730 | -0.097 | -3 | 0.799 |
PAK6 |
0.730 | -0.001 | -2 | 0.674 |
YSK4 |
0.729 | -0.095 | 1 | 0.256 |
BUB1 |
0.729 | 0.190 | -5 | 0.760 |
WNK3 |
0.729 | -0.236 | 1 | 0.286 |
MNK1 |
0.729 | -0.029 | -2 | 0.772 |
AURB |
0.728 | -0.005 | -2 | 0.624 |
IRE2 |
0.728 | -0.125 | 2 | 0.657 |
NEK2 |
0.728 | -0.085 | 2 | 0.714 |
PRKX |
0.728 | 0.030 | -3 | 0.663 |
CHAK1 |
0.728 | -0.130 | 2 | 0.707 |
TSSK1 |
0.728 | -0.088 | -3 | 0.832 |
MSK2 |
0.728 | -0.039 | -3 | 0.732 |
PERK |
0.727 | -0.043 | -2 | 0.875 |
MEK1 |
0.727 | -0.109 | 2 | 0.745 |
TSSK2 |
0.727 | -0.125 | -5 | 0.796 |
QSK |
0.727 | -0.067 | 4 | 0.786 |
SGK3 |
0.726 | -0.012 | -3 | 0.739 |
MYLK4 |
0.726 | -0.038 | -2 | 0.756 |
PKG2 |
0.726 | -0.015 | -2 | 0.636 |
PIM2 |
0.726 | 0.022 | -3 | 0.711 |
MPSK1 |
0.726 | 0.024 | 1 | 0.348 |
MLK4 |
0.726 | -0.128 | 2 | 0.639 |
CK1E |
0.725 | -0.001 | -3 | 0.598 |
PKCH |
0.725 | -0.079 | 2 | 0.642 |
MST3 |
0.725 | -0.035 | 2 | 0.773 |
CAMK2B |
0.724 | -0.080 | 2 | 0.675 |
CAMK2A |
0.724 | -0.054 | 2 | 0.691 |
PLK1 |
0.724 | -0.138 | -2 | 0.819 |
NUAK1 |
0.724 | -0.073 | -3 | 0.749 |
MSK1 |
0.723 | -0.021 | -3 | 0.733 |
PAK2 |
0.722 | -0.071 | -2 | 0.735 |
MELK |
0.722 | -0.101 | -3 | 0.758 |
QIK |
0.722 | -0.136 | -3 | 0.791 |
NEK5 |
0.721 | -0.080 | 1 | 0.285 |
DRAK1 |
0.721 | -0.125 | 1 | 0.237 |
CK1D |
0.721 | 0.029 | -3 | 0.552 |
MARK3 |
0.721 | -0.075 | 4 | 0.738 |
CAMK4 |
0.721 | -0.126 | -3 | 0.774 |
TLK1 |
0.721 | -0.072 | -2 | 0.857 |
PLK4 |
0.721 | -0.131 | 2 | 0.542 |
PASK |
0.720 | -0.019 | -3 | 0.851 |
SIK |
0.720 | -0.075 | -3 | 0.727 |
AURA |
0.720 | -0.019 | -2 | 0.597 |
DCAMKL1 |
0.720 | -0.051 | -3 | 0.758 |
TAO3 |
0.720 | -0.028 | 1 | 0.303 |
BRSK1 |
0.720 | -0.088 | -3 | 0.763 |
MAPKAPK5 |
0.719 | -0.051 | -3 | 0.695 |
GRK2 |
0.719 | -0.083 | -2 | 0.697 |
LKB1 |
0.718 | 0.042 | -3 | 0.817 |
MEKK1 |
0.718 | -0.137 | 1 | 0.295 |
BRSK2 |
0.718 | -0.111 | -3 | 0.769 |
PKCT |
0.717 | -0.067 | 2 | 0.644 |
PLK3 |
0.717 | -0.130 | 2 | 0.667 |
MEKK2 |
0.717 | -0.127 | 2 | 0.702 |
MEK5 |
0.717 | -0.160 | 2 | 0.725 |
AKT1 |
0.717 | -0.004 | -3 | 0.683 |
HRI |
0.716 | -0.131 | -2 | 0.877 |
PKCI |
0.716 | -0.040 | 2 | 0.665 |
WNK4 |
0.716 | -0.124 | -2 | 0.855 |
ZAK |
0.715 | -0.155 | 1 | 0.271 |
IRAK4 |
0.715 | -0.152 | 1 | 0.280 |
CK1A2 |
0.715 | 0.001 | -3 | 0.551 |
MEKK3 |
0.715 | -0.179 | 1 | 0.281 |
PKACA |
0.715 | 0.008 | -2 | 0.595 |
GAK |
0.715 | -0.026 | 1 | 0.341 |
CAMK1G |
0.715 | -0.077 | -3 | 0.725 |
CK1G1 |
0.715 | -0.039 | -3 | 0.603 |
MARK2 |
0.715 | -0.100 | 4 | 0.716 |
PKCE |
0.714 | -0.020 | 2 | 0.661 |
CK2A2 |
0.713 | -0.072 | 1 | 0.252 |
DCAMKL2 |
0.713 | -0.067 | -3 | 0.765 |
SNRK |
0.713 | -0.175 | 2 | 0.584 |
PDK1 |
0.712 | -0.059 | 1 | 0.316 |
GSK3B |
0.712 | 0.009 | 4 | 0.365 |
CHK1 |
0.712 | -0.073 | -3 | 0.776 |
GCK |
0.712 | -0.025 | 1 | 0.272 |
SMMLCK |
0.711 | -0.053 | -3 | 0.781 |
NEK11 |
0.711 | -0.107 | 1 | 0.291 |
BRAF |
0.711 | -0.146 | -4 | 0.774 |
PAK5 |
0.710 | -0.033 | -2 | 0.609 |
SSTK |
0.710 | -0.093 | 4 | 0.773 |
HASPIN |
0.710 | 0.048 | -1 | 0.713 |
NEK8 |
0.710 | -0.138 | 2 | 0.723 |
MAP3K15 |
0.709 | -0.062 | 1 | 0.275 |
PHKG2 |
0.709 | -0.102 | -3 | 0.747 |
TAO2 |
0.709 | -0.071 | 2 | 0.751 |
MARK1 |
0.709 | -0.125 | 4 | 0.759 |
TNIK |
0.708 | -0.027 | 3 | 0.562 |
PAK4 |
0.708 | -0.033 | -2 | 0.613 |
HPK1 |
0.708 | -0.037 | 1 | 0.271 |
P70S6K |
0.708 | -0.033 | -3 | 0.671 |
NEK4 |
0.707 | -0.100 | 1 | 0.262 |
LOK |
0.707 | -0.012 | -2 | 0.740 |
ROCK2 |
0.706 | 0.015 | -3 | 0.756 |
GRK3 |
0.706 | -0.085 | -2 | 0.659 |
SLK |
0.706 | -0.005 | -2 | 0.685 |
DAPK3 |
0.706 | -0.038 | -3 | 0.775 |
AKT3 |
0.706 | 0.006 | -3 | 0.617 |
SGK1 |
0.706 | 0.025 | -3 | 0.596 |
CAMKK2 |
0.706 | -0.062 | -2 | 0.745 |
CAMKK1 |
0.706 | -0.127 | -2 | 0.746 |
HGK |
0.706 | -0.070 | 3 | 0.552 |
PBK |
0.706 | 0.012 | 1 | 0.310 |
SBK |
0.705 | 0.102 | -3 | 0.549 |
KHS2 |
0.705 | -0.018 | 1 | 0.277 |
KHS1 |
0.705 | -0.026 | 1 | 0.270 |
TTBK1 |
0.705 | -0.170 | 2 | 0.526 |
CK2A1 |
0.704 | -0.077 | 1 | 0.239 |
MEKK6 |
0.704 | -0.081 | 1 | 0.282 |
LRRK2 |
0.703 | -0.047 | 2 | 0.744 |
MRCKB |
0.703 | -0.005 | -3 | 0.702 |
MINK |
0.703 | -0.103 | 1 | 0.255 |
MST2 |
0.703 | -0.106 | 1 | 0.269 |
NEK1 |
0.703 | -0.087 | 1 | 0.267 |
CHK2 |
0.701 | -0.018 | -3 | 0.608 |
VRK1 |
0.701 | -0.152 | 2 | 0.760 |
PKN1 |
0.700 | -0.062 | -3 | 0.684 |
EEF2K |
0.700 | -0.132 | 3 | 0.479 |
CAMK1D |
0.699 | -0.058 | -3 | 0.649 |
DAPK1 |
0.699 | -0.047 | -3 | 0.761 |
STK33 |
0.699 | -0.120 | 2 | 0.540 |
IRAK1 |
0.697 | -0.238 | -1 | 0.686 |
TAK1 |
0.697 | -0.147 | 1 | 0.262 |
MST1 |
0.697 | -0.102 | 1 | 0.257 |
DMPK1 |
0.697 | 0.015 | -3 | 0.727 |
MRCKA |
0.695 | -0.024 | -3 | 0.714 |
PLK2 |
0.694 | -0.090 | -3 | 0.769 |
CRIK |
0.693 | 0.028 | -3 | 0.684 |
OSR1 |
0.693 | -0.034 | 2 | 0.704 |
PDHK3_TYR |
0.693 | 0.146 | 4 | 0.856 |
YSK1 |
0.693 | -0.114 | 2 | 0.710 |
NEK3 |
0.692 | -0.073 | 1 | 0.281 |
CAMK1A |
0.690 | -0.045 | -3 | 0.634 |
ROCK1 |
0.690 | -0.007 | -3 | 0.715 |
BIKE |
0.690 | -0.021 | 1 | 0.313 |
MEK2 |
0.688 | -0.174 | 2 | 0.703 |
TTK |
0.688 | -0.079 | -2 | 0.855 |
PKMYT1_TYR |
0.687 | 0.145 | 3 | 0.563 |
MYO3B |
0.687 | -0.044 | 2 | 0.732 |
LIMK2_TYR |
0.687 | 0.157 | -3 | 0.846 |
TESK1_TYR |
0.686 | 0.085 | 3 | 0.574 |
AAK1 |
0.686 | 0.018 | 1 | 0.298 |
PDHK4_TYR |
0.686 | 0.092 | 2 | 0.788 |
ASK1 |
0.686 | -0.085 | 1 | 0.277 |
RIPK2 |
0.684 | -0.238 | 1 | 0.245 |
MAP2K6_TYR |
0.683 | 0.068 | -1 | 0.780 |
MAP2K4_TYR |
0.683 | 0.081 | -1 | 0.773 |
PKG1 |
0.682 | -0.050 | -2 | 0.550 |
TAO1 |
0.682 | -0.072 | 1 | 0.263 |
YANK3 |
0.682 | -0.067 | 2 | 0.350 |
CK1A |
0.681 | -0.021 | -3 | 0.474 |
MYO3A |
0.680 | -0.100 | 1 | 0.291 |
PDHK1_TYR |
0.680 | -0.003 | -1 | 0.795 |
BMPR2_TYR |
0.680 | 0.035 | -1 | 0.787 |
MAP2K7_TYR |
0.679 | -0.057 | 2 | 0.760 |
ALPHAK3 |
0.678 | -0.086 | -1 | 0.673 |
ABL2 |
0.677 | 0.079 | -1 | 0.695 |
RET |
0.675 | -0.052 | 1 | 0.305 |
EPHA6 |
0.674 | -0.039 | -1 | 0.777 |
PINK1_TYR |
0.674 | -0.113 | 1 | 0.347 |
EPHB4 |
0.673 | -0.019 | -1 | 0.746 |
ABL1 |
0.673 | 0.070 | -1 | 0.686 |
MST1R |
0.673 | -0.038 | 3 | 0.552 |
CSF1R |
0.672 | -0.040 | 3 | 0.532 |
LIMK1_TYR |
0.672 | -0.015 | 2 | 0.749 |
JAK2 |
0.671 | -0.051 | 1 | 0.310 |
TXK |
0.670 | -0.031 | 1 | 0.270 |
LCK |
0.670 | -0.038 | -1 | 0.763 |
TYRO3 |
0.667 | -0.118 | 3 | 0.522 |
TNK2 |
0.667 | -0.062 | 3 | 0.492 |
BLK |
0.666 | -0.051 | -1 | 0.765 |
YES1 |
0.666 | -0.099 | -1 | 0.762 |
KIT |
0.664 | -0.063 | 3 | 0.531 |
ITK |
0.664 | -0.078 | -1 | 0.715 |
FGR |
0.664 | -0.114 | 1 | 0.273 |
ROS1 |
0.664 | -0.161 | 3 | 0.481 |
JAK3 |
0.664 | -0.109 | 1 | 0.296 |
TNK1 |
0.664 | -0.042 | 3 | 0.522 |
HCK |
0.663 | -0.098 | -1 | 0.752 |
NEK10_TYR |
0.663 | -0.055 | 1 | 0.252 |
TYK2 |
0.663 | -0.202 | 1 | 0.294 |
EPHA4 |
0.663 | -0.031 | 2 | 0.697 |
KDR |
0.663 | -0.078 | 3 | 0.471 |
STLK3 |
0.663 | -0.173 | 1 | 0.248 |
FGFR2 |
0.662 | -0.069 | 3 | 0.487 |
MET |
0.662 | -0.037 | 3 | 0.543 |
TEK |
0.661 | -0.047 | 3 | 0.458 |
FYN |
0.660 | -0.051 | -1 | 0.752 |
EPHB2 |
0.660 | -0.068 | -1 | 0.728 |
JAK1 |
0.659 | -0.091 | 1 | 0.269 |
TNNI3K_TYR |
0.659 | -0.059 | 1 | 0.334 |
EPHB3 |
0.659 | -0.081 | -1 | 0.730 |
CK1G3 |
0.658 | -0.036 | -3 | 0.438 |
FGFR1 |
0.658 | -0.077 | 3 | 0.479 |
EPHB1 |
0.658 | -0.120 | 1 | 0.275 |
INSRR |
0.658 | -0.153 | 3 | 0.448 |
MERTK |
0.658 | -0.087 | 3 | 0.519 |
FER |
0.658 | -0.153 | 1 | 0.296 |
SRMS |
0.658 | -0.115 | 1 | 0.272 |
FLT3 |
0.658 | -0.135 | 3 | 0.521 |
DDR1 |
0.657 | -0.163 | 4 | 0.753 |
BMX |
0.656 | -0.092 | -1 | 0.644 |
PTK2B |
0.655 | 0.005 | -1 | 0.688 |
FGFR3 |
0.653 | -0.079 | 3 | 0.461 |
PDGFRB |
0.653 | -0.183 | 3 | 0.515 |
FLT1 |
0.653 | -0.086 | -1 | 0.723 |
WEE1_TYR |
0.651 | -0.099 | -1 | 0.670 |
AXL |
0.651 | -0.146 | 3 | 0.505 |
FRK |
0.650 | -0.110 | -1 | 0.755 |
EPHA7 |
0.650 | -0.102 | 2 | 0.685 |
LYN |
0.650 | -0.109 | 3 | 0.464 |
CK1G2 |
0.650 | -0.034 | -3 | 0.527 |
EPHA1 |
0.649 | -0.098 | 3 | 0.529 |
TEC |
0.649 | -0.126 | -1 | 0.650 |
PTK2 |
0.649 | -0.006 | -1 | 0.719 |
ERBB2 |
0.649 | -0.141 | 1 | 0.267 |
ZAP70 |
0.648 | 0.046 | -1 | 0.620 |
SYK |
0.647 | -0.006 | -1 | 0.691 |
SRC |
0.647 | -0.106 | -1 | 0.732 |
EPHA3 |
0.647 | -0.096 | 2 | 0.660 |
PDGFRA |
0.647 | -0.193 | 3 | 0.518 |
YANK2 |
0.647 | -0.087 | 2 | 0.363 |
ALK |
0.646 | -0.178 | 3 | 0.447 |
DDR2 |
0.646 | -0.082 | 3 | 0.430 |
EPHA8 |
0.645 | -0.081 | -1 | 0.721 |
BTK |
0.644 | -0.205 | -1 | 0.678 |
EPHA5 |
0.644 | -0.082 | 2 | 0.678 |
EGFR |
0.644 | -0.094 | 1 | 0.228 |
LTK |
0.644 | -0.173 | 3 | 0.474 |
FLT4 |
0.643 | -0.164 | 3 | 0.460 |
MATK |
0.643 | -0.085 | -1 | 0.625 |
FGFR4 |
0.643 | -0.084 | -1 | 0.655 |
INSR |
0.642 | -0.178 | 3 | 0.453 |
NTRK1 |
0.641 | -0.199 | -1 | 0.696 |
ERBB4 |
0.640 | -0.070 | 1 | 0.237 |
PTK6 |
0.640 | -0.190 | -1 | 0.624 |
NTRK3 |
0.639 | -0.144 | -1 | 0.650 |
EPHA2 |
0.638 | -0.070 | -1 | 0.681 |
NTRK2 |
0.637 | -0.207 | 3 | 0.473 |
CSK |
0.636 | -0.132 | 2 | 0.680 |
MUSK |
0.634 | -0.111 | 1 | 0.215 |
IGF1R |
0.629 | -0.162 | 3 | 0.410 |
FES |
0.617 | -0.154 | -1 | 0.612 |