Motif 749 (n=206)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0B4J293 None S315 ochoa RNF31 protein None
A5A3E0 POTEF S939 ochoa POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) None
A5YM69 ARHGEF35 S57 ochoa Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) None
B2RPK0 HMGB1P1 S121 ochoa High mobility group protein B1-like 1 (High mobility group protein 1-like 1) (HMG-1L1) Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}.
B4DGG1 FAM234A S21 ochoa Protein FAM234A (Protein ITFG3) None
O00592 PODXL S519 ochoa Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}.
O14976 GAK S817 ochoa Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}.
O43432 EIF4G3 S1218 ochoa Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}.
O43707 ACTN4 S62 ochoa Alpha-actinin-4 (Non-muscle alpha-actinin 4) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}.
O43709 BUD23 S240 ochoa 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). {ECO:0000250, ECO:0000269|PubMed:24086612, ECO:0000269|PubMed:24488492, ECO:0000269|PubMed:25851604}.
O43829 ZBTB14 S222 ochoa Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}.
O60269 GPRIN2 S429 ochoa G protein-regulated inducer of neurite outgrowth 2 (GRIN2) May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}.
O60341 KDM1A S111 psp Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}.
O60934 NBN S611 ochoa Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}.
O75146 HIP1R S592 ochoa Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.
O75167 PHACTR2 S423 ochoa Phosphatase and actin regulator 2 None
O75170 PPP6R2 S427 ochoa Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}.
O75179 ANKRD17 S156 ochoa Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
O75362 ZNF217 S345 ochoa Zinc finger protein 217 Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.
O75976 CPD S1358 ochoa Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) None
O76021 RSL1D1 S427 ochoa Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.
O76094 SRP72 S81 ochoa Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}.
O94880 PHF14 S91 ochoa PHD finger protein 14 Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.
O94880 PHF14 S92 ochoa PHD finger protein 14 Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.
O94885 SASH1 S721 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94988 FAM13A S539 ochoa Protein FAM13A None
O95757 HSPA4L S517 ochoa Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}.
O95972 BMP15 S273 psp Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B) May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. {ECO:0000269|PubMed:18227435}.
O96017 CHEK2 S140 psp Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}.
P02545 LMNA S277 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P07437 TUBB S40 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P07814 EPRS1 S330 ochoa Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}.
P08151 GLI1 S243 psp Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
P09429 HMGB1 S121 ochoa High mobility group protein B1 (High mobility group protein 1) (HMG-1) Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}.
P09651 HNRNPA1 S22 ochoa Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}.
P12814 ACTN1 S43 ochoa Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}.
P13521 SCG2 S268 ochoa Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}.
P15382 KCNE1 S102 psp Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel) (MinK) Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:19219384, PubMed:20533308, PubMed:9230439). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization (PubMed:20533308). The outward current reaches its steady state only after 50 seconds (Probable). Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (PubMed:9230439). {ECO:0000269|PubMed:19219384, ECO:0000269|PubMed:20533308, ECO:0000269|PubMed:9230439, ECO:0000305}.
P16591 FER S408 ochoa Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}.
P16615 ATP2A2 S504 ochoa Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.
P17936 IGFBP3 S204 ochoa Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}.
P20700 LMNB1 S278 ochoa Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P20807 CAPN3 S636 psp Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:27657329}.
P22626 HNRNPA2B1 S29 ochoa Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}.
P25686 DNAJB2 S264 psp DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}.
P26583 HMGB2 S121 ochoa High mobility group protein B2 (High mobility group protein 2) (HMG-2) Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}.
P28698 MZF1 S177 ochoa Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. {ECO:0000269|PubMed:15541732, ECO:0000269|PubMed:17851584}.
P29350 PTPN6 S250 ochoa Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}.
P30622 CLIP1 S973 ochoa CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P34932 HSPA4 S546 ochoa Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) None
P35442 THBS2 S258 ochoa Thrombospondin-2 Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. {ECO:0000269|PubMed:20714802}.
P35555 FBN1 S2564 ochoa Fibrillin-1 [Cleaved into: Asprosin] [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:15062093, PubMed:1860873). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15062093, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:1860873, ECO:0000269|PubMed:24039232, ECO:0000303|PubMed:27026396}.; FUNCTION: [Asprosin]: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:27087445, ECO:0000269|PubMed:30853600, ECO:0000269|PubMed:31230984}.
P35609 ACTN2 S50 ochoa Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
P46100 ATRX S1236 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46100 ATRX S1418 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46821 MAP1B S977 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P49321 NASP S210 ochoa Nuclear autoantigenic sperm protein (NASP) Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.
P49643 PRIM2 S170 ochoa DNA primase large subunit (DNA primase 58 kDa subunit) (p58) Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:17893144, PubMed:25550159, PubMed:26975377, PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144, PubMed:25550159). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch. {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P33610, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:9705292}.
P51003 PAPOLA S681 ochoa Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}.
P51797 CLCN6 S683 ochoa H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6) Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. {ECO:0000269|PubMed:20466723}.
P51991 HNRNPA3 S43 ochoa Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}.
P52789 HK2 Y686 psp Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}.
P54296 MYOM2 S1388 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P55895 RAG2 S365 psp V(D)J recombination-activating protein 2 (RAG-2) Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity). {ECO:0000250}.
P56945 BCAR1 S694 ochoa Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
P57737 CORO7 S807 ochoa Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}.
P61981 YWHAG S149 ochoa 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}.
P78345 RPP38 S235 ochoa Ribonuclease P protein subunit p38 (RNaseP protein p38) Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}.
P78536 ADAM17 S791 ochoa|psp Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}.
P78559 MAP1A S771 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P82094 TMF1 S197 ochoa TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.
Q02410 APBA1 S263 ochoa Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}.
Q02952 AKAP12 S1712 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03164 KMT2A S3644 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q03252 LMNB2 S292 ochoa Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q08043 ACTN3 S57 ochoa Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Q08AD1 CAMSAP2 S715 ochoa Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.
Q0ZGT2 NEXN S218 ochoa Nexilin (F-actin-binding protein) (Nelin) Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.
Q12774 ARHGEF5 S57 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12873 CHD3 S604 ochoa Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}.
Q12888 TP53BP1 S507 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S765 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S1037 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12905 ILF2 S68 ochoa Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.
Q13061 TRDN S418 ochoa Triadin Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}.
Q13201 MMRN1 S522 ochoa Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}.
Q13416 ORC2 S143 ochoa Origin recognition complex subunit 2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Q13422 IKZF1 S261 ochoa DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}.
Q14493 SLBP S221 psp Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}.
Q15020 SART3 S769 ochoa Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}.
Q15311 RALBP1 S463 ochoa RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}.
Q15424 SAFB S384 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15475 SIX1 S204 ochoa Homeobox protein SIX1 (Sine oculis homeobox homolog 1) Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as a transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PubMed:15141091). Mediates nuclear translocation of EYA1 and EYA2 (PubMed:19497856). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PubMed:15141091, PubMed:19497856, PubMed:23435380, PubMed:27923061). Regulates the expression of numerous genes, including MYC, CCND1 and EZR (By similarity). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (PubMed:15123840). Promotes brown adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q62231, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141091, ECO:0000269|PubMed:19497856, ECO:0000269|PubMed:23435380, ECO:0000269|PubMed:27923061}.
Q15744 CEBPE S21 ochoa CCAAT/enhancer-binding protein epsilon (C/EBP epsilon) Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). {ECO:0000269|PubMed:10359588, ECO:0000269|PubMed:26019275}.
Q15785 TOMM34 S231 ochoa Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}.
Q16649 NFIL3 S210 ochoa Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}.
Q16891 IMMT S528 psp MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q29RF7 PDS5A S1233 ochoa Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.
Q2KHR3 QSER1 S607 ochoa Glutamine and serine-rich protein 1 Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}.
Q32MZ4 LRRFIP1 S638 ochoa Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.
Q32P51 HNRNPA1L2 S22 ochoa Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}.
Q4VC05 BCL7A S164 ochoa B-cell CLL/lymphoma 7 protein family member A None
Q562R1 ACTBL2 S240 ochoa Beta-actin-like protein 2 (Kappa-actin) Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}.
Q5F1R6 DNAJC21 S283 ochoa DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}.
Q5H9R7 PPP6R3 S665 ochoa Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}.
Q5JSL3 DOCK11 S306 ochoa Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}.
Q5SW79 CEP170 S269 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T8I3 EEIG2 S276 ochoa EEIG family member 2 (EEIG2) None
Q5TB80 CEP162 S24 ochoa Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}.
Q5VTR2 RNF20 S545 psp E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
Q5VYK3 ECPAS S1666 psp Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}.
Q66GS9 CEP135 S253 ochoa Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27477386}.
Q6IEG0 SNRNP48 S277 ochoa U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein) (U11/U12-48K) Likely involved in U12-type 5' splice site recognition. {ECO:0000269|PubMed:19217400}.
Q6P444 MTFR2 S343 ochoa Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}.
Q6PL18 ATAD2 S1276 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q6WCQ1 MPRIP S326 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6YHK3 CD109 S1129 ochoa CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269|PubMed:16754747}.
Q7Z2K8 GPRIN1 S116 ochoa G protein-regulated inducer of neurite outgrowth 1 (GRIN1) May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z5K2 WAPL S1069 ochoa Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.
Q7Z6Z7 HUWE1 S2362 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q7Z6Z7 HUWE1 S3263 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86VY9 TMEM200A S471 ochoa Transmembrane protein 200A None
Q8IWC1 MAP7D3 S441 ochoa MAP7 domain-containing protein 3 Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.
Q8IYF3 TEX11 S190 ochoa Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. {ECO:0000250|UniProtKB:Q14AT2}.
Q8IYN2 TCEAL8 S43 ochoa Transcription elongation factor A protein-like 8 (TCEA-like protein 8) (Transcription elongation factor S-II protein-like 8) May be involved in transcriptional regulation.
Q8N163 CCAR2 S478 ochoa Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}.
Q8N3U4 STAG2 S1177 ochoa Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}.
Q8N565 MREG S39 ochoa Melanoregulin (Dilute suppressor protein homolog) Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). {ECO:0000250|UniProtKB:Q6NVG5, ECO:0000269|PubMed:19240024}.
Q8N573 OXR1 S355 ochoa Oxidation resistance protein 1 May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}.
Q8NDI1 EHBP1 S730 ochoa EH domain-binding protein 1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.
Q8NEG4 FAM83F S61 ochoa Protein FAM83F None
Q8NEY8 PPHLN1 S244 ochoa Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}.
Q8NEZ4 KMT2C S2811 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8TAQ2 SMARCC2 S754 ochoa SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q8TD26 CHD6 S1714 ochoa Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.
Q8TF01 PNISR S467 ochoa Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) None
Q8WWK9 CKAP2 S534 ochoa Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
Q92551 IP6K1 S174 ochoa Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Q92598 HSPH1 S509 ochoa Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}.
Q96EP0 RNF31 S840 ochoa E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}.
Q96PE2 ARHGEF17 S861 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96QK1 VPS35 S228 ochoa Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}.
Q96R06 SPAG5 S159 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96RS0 TGS1 S158 ochoa Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
Q96T23 RSF1 S314 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q99590 SCAF11 S1012 ochoa Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}.
Q99689 FEZ1 S58 ochoa|psp Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1) May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.
Q9BYX7 POTEKP S239 ochoa Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K) None
Q9BZ95 NSD3 S913 ochoa Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.
Q9BZI7 UPF3B S409 ochoa Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}.
Q9C0D2 CEP295 S1205 ochoa Centrosomal protein of 295 kDa Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}.
Q9H0A0 NAT10 S987 ochoa RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}.
Q9H0G5 NSRP1 S146 ochoa Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}.
Q9H0X4 FAM234A S21 ochoa Protein FAM234A (Protein ITFG3) None
Q9H2P0 ADNP S923 ochoa Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}.
Q9H4L7 SMARCAD1 S239 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Q9H7E2 TDRD3 Y190 ochoa Tudor domain-containing protein 3 Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}.
Q9HAU0 PLEKHA5 S1037 ochoa Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) None
Q9HBH0 RHOF S64 ochoa Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia) Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
Q9HBR0 SLC38A10 S997 ochoa Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q5I012}.
Q9NS91 RAD18 S471 ochoa E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}.
Q9NUA8 ZBTB40 S160 ochoa Zinc finger and BTB domain-containing protein 40 May be involved in transcriptional regulation.
Q9NVM9 INTS13 S626 ochoa Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling (PubMed:23097494, PubMed:23904267). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (PubMed:23097494, PubMed:23904267). {ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142}.
Q9NXV6 CDKN2AIP S133 ochoa CDKN2A-interacting protein (Collaborator of ARF) Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}.
Q9NZJ5 EIF2AK3 S567 ochoa Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:10026192, ECO:0000269|PubMed:10677345, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:12086964, ECO:0000269|PubMed:25925385, ECO:0000269|PubMed:27917829, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39116259}.
Q9NZN5 ARHGEF12 S1170 ochoa Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.
Q9P289 STK26 S325 ochoa Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}.
Q9P2K8 EIF2AK4 S207 ochoa eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}.
Q9UDY2 TJP2 S1012 ochoa Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.
Q9UEW8 STK39 S401 ochoa STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}.
Q9UJU6 DBNL Y224 ochoa Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}.
Q9UKA4 AKAP11 S1171 ochoa A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Q9UKL3 CASP8AP2 S1278 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9UKX7 NUP50 S204 ochoa Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.
Q9ULS5 TMCC3 S242 ochoa Transmembrane and coiled-coil domain protein 3 None
Q9UMY1 NOL7 S133 ochoa U3 small nucleolar RNA-associated protein NOL7 (U3 snoRNA-associated protein NOL7) (Nucleolar protein 7) (Nucleolar protein of 27 kDa) Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (PubMed:34516797, PubMed:37246770). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA (PubMed:37246770). Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability (PubMed:37246770). {ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:37246770}.
Q9UPQ0 LIMCH1 S611 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UPV0 CEP164 S380 ochoa Centrosomal protein of 164 kDa (Cep164) Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Q9UPV0 CEP164 S407 ochoa Centrosomal protein of 164 kDa (Cep164) Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Q9Y2F5 ICE1 S1255 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y3S1 WNK2 S1276 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y4D1 DAAM1 S1030 ochoa Disheveled-associated activator of morphogenesis 1 Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.
Q9Y520 PRRC2C S848 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y5B9 SUPT16H S982 ochoa FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
Q9Y6D5 ARFGEF2 S1513 ochoa Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}.
Q9Y6K9 IKBKG S43 psp NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}.
Q9Y6M5 SLC30A1 S473 ochoa Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}.
Q9Y6Q9 NCOA3 S778 ochoa Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
A0A2R8Y4L2 HNRNPA1L3 S22 Sugiyama Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) None
P31327 CPS1 S569 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Q02818 NUCB1 S193 Sugiyama Nucleobindin-1 (CALNUC) Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}.
Q08752 PPID S119 Sugiyama Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779, ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}.; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269|PubMed:19932913, ECO:0000269|PubMed:21711559}.
Q9UNN5 FAF1 S518 Sugiyama FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}.
O94768 STK17B S351 Sugiyama Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. {ECO:0000250, ECO:0000269|PubMed:9786912}.
P26641 EEF1G S286 Sugiyama Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) Probably plays a role in anchoring the complex to other cellular components.
Q9UI26 IPO11 S214 Sugiyama Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11) Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11032817}.
Q9UBS4 DNAJB11 S78 Sugiyama DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4) As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676, ECO:0000269|PubMed:29706351}.
P49336 CDK8 S244 Sugiyama Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35) Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. {ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:30905399}.
P23284 PPIB S139 Sugiyama Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}.
Q9C0C2 TNKS1BP1 S1229 Sugiyama 182 kDa tankyrase-1-binding protein None
Q14BN4 SLMAP S280 Sugiyama Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}.
Q99700 ATXN2 S451 Sugiyama Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q00341 HDLBP S216 Sugiyama Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Q08378 GOLGA3 S1036 Sugiyama Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) Golgi auto-antigen; probably involved in maintaining Golgi structure.
Q99961 SH3GL1 S120 Sugiyama Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.
Q9BRQ0 PYGO2 S349 Sugiyama Pygopus homolog 2 Involved in signal transduction through the Wnt pathway.
Download
reactome_id name p -log10_p
R-HSA-75153 Apoptotic execution phase 0.000011 4.978
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.000185 3.733
R-HSA-2470946 Cohesin Loading onto Chromatin 0.000364 3.439
R-HSA-373753 Nephrin family interactions 0.000401 3.397
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.000777 3.110
R-HSA-352238 Breakdown of the nuclear lamina 0.000792 3.101
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.001170 2.932
R-HSA-8957275 Post-translational protein phosphorylation 0.003876 2.412
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.004606 2.337
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.003898 2.409
R-HSA-114608 Platelet degranulation 0.003401 2.468
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.004406 2.356
R-HSA-1640170 Cell Cycle 0.002226 2.652
R-HSA-109581 Apoptosis 0.003337 2.477
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.005388 2.269
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.006063 2.217
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.007964 2.099
R-HSA-68877 Mitotic Prometaphase 0.008617 2.065
R-HSA-68886 M Phase 0.009120 2.040
R-HSA-73887 Death Receptor Signaling 0.009320 2.031
R-HSA-3371556 Cellular response to heat stress 0.010529 1.978
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.011524 1.938
R-HSA-193648 NRAGE signals death through JNK 0.011493 1.940
R-HSA-5357801 Programmed Cell Death 0.011990 1.921
R-HSA-2980766 Nuclear Envelope Breakdown 0.012103 1.917
R-HSA-140342 Apoptosis induced DNA fragmentation 0.013616 1.866
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.016199 1.791
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.016199 1.791
R-HSA-8854518 AURKA Activation by TPX2 0.018537 1.732
R-HSA-76002 Platelet activation, signaling and aggregation 0.019196 1.717
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.017735 1.751
R-HSA-193704 p75 NTR receptor-mediated signalling 0.017364 1.760
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.026593 1.575
R-HSA-9673013 Diseases of Telomere Maintenance 0.026593 1.575
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.026593 1.575
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.026593 1.575
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.026593 1.575
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.022483 1.648
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.024987 1.602
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.024772 1.606
R-HSA-380287 Centrosome maturation 0.026759 1.573
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.021119 1.675
R-HSA-69473 G2/M DNA damage checkpoint 0.025754 1.589
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.024987 1.602
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.022483 1.648
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.019718 1.705
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.024772 1.606
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.027598 1.559
R-HSA-3214841 PKMTs methylate histone lysines 0.027773 1.556
R-HSA-69278 Cell Cycle, Mitotic 0.028999 1.538
R-HSA-9020591 Interleukin-12 signaling 0.027787 1.556
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 0.039625 1.402
R-HSA-5602636 IKBKB deficiency causes SCID 0.039625 1.402
R-HSA-9842640 Signaling by LTK in cancer 0.114246 0.942
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.114246 0.942
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.137814 0.861
R-HSA-9700645 ALK mutants bind TKIs 0.149363 0.826
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.045354 1.343
R-HSA-68952 DNA replication initiation 0.160757 0.794
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.183093 0.737
R-HSA-69109 Leading Strand Synthesis 0.194038 0.712
R-HSA-69091 Polymerase switching 0.194038 0.712
R-HSA-3000484 Scavenging by Class F Receptors 0.194038 0.712
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.204837 0.689
R-HSA-69166 Removal of the Flap Intermediate 0.215493 0.667
R-HSA-390522 Striated Muscle Contraction 0.102082 0.991
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.102082 0.991
R-HSA-1221632 Meiotic synapsis 0.050309 1.298
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.256710 0.591
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.065190 1.186
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.132823 0.877
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.276503 0.558
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.043297 1.364
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.076915 1.114
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.286202 0.543
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.286202 0.543
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.286202 0.543
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.286202 0.543
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.295772 0.529
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.305213 0.515
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.305213 0.515
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.305213 0.515
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.122820 0.911
R-HSA-72187 mRNA 3'-end processing 0.194153 0.712
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.341737 0.466
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.297954 0.526
R-HSA-72172 mRNA Splicing 0.084383 1.074
R-HSA-69186 Lagging Strand Synthesis 0.295772 0.529
R-HSA-72163 mRNA Splicing - Major Pathway 0.162228 0.790
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.350565 0.455
R-HSA-5693607 Processing of DNA double-strand break ends 0.337334 0.472
R-HSA-69183 Processive synthesis on the lagging strand 0.226005 0.646
R-HSA-9932451 SWI/SNF chromatin remodelers 0.066219 1.179
R-HSA-9932444 ATP-dependent chromatin remodelers 0.066219 1.179
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.062953 1.201
R-HSA-5693606 DNA Double Strand Break Response 0.081846 1.087
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.183093 0.737
R-HSA-68962 Activation of the pre-replicative complex 0.085555 1.068
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.292529 0.534
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.292529 0.534
R-HSA-5576890 Phase 3 - rapid repolarisation 0.126109 0.899
R-HSA-933542 TRAF6 mediated NF-kB activation 0.062551 1.204
R-HSA-174430 Telomere C-strand synthesis initiation 0.226005 0.646
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.246612 0.608
R-HSA-73856 RNA Polymerase II Transcription Termination 0.067464 1.171
R-HSA-6803529 FGFR2 alternative splicing 0.314529 0.502
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.292529 0.534
R-HSA-9662834 CD163 mediating an anti-inflammatory response 0.172000 0.764
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.111006 0.955
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.090036 1.046
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.062551 1.204
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.073761 1.132
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.246612 0.608
R-HSA-6798695 Neutrophil degranulation 0.317448 0.498
R-HSA-9842860 Regulation of endogenous retroelements 0.067863 1.168
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.084777 1.072
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.050309 1.298
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.176258 0.754
R-HSA-5603029 IkBA variant leads to EDA-ID 0.102222 0.990
R-HSA-68689 CDC6 association with the ORC:origin complex 0.102222 0.990
R-HSA-113510 E2F mediated regulation of DNA replication 0.042162 1.375
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.194038 0.712
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.204837 0.689
R-HSA-1855191 Synthesis of IPs in the nucleus 0.215493 0.667
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.226005 0.646
R-HSA-1500620 Meiosis 0.038098 1.419
R-HSA-191859 snRNP Assembly 0.228495 0.641
R-HSA-194441 Metabolism of non-coding RNA 0.228495 0.641
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.243349 0.614
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.170077 0.769
R-HSA-9843745 Adipogenesis 0.138615 0.858
R-HSA-212165 Epigenetic regulation of gene expression 0.044351 1.353
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.266673 0.574
R-HSA-5260271 Diseases of Immune System 0.132823 0.877
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.132823 0.877
R-HSA-9620244 Long-term potentiation 0.341737 0.466
R-HSA-111447 Activation of BAD and translocation to mitochondria 0.226005 0.646
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.314529 0.502
R-HSA-3214815 HDACs deacetylate histones 0.208801 0.680
R-HSA-5357905 Regulation of TNFR1 signaling 0.165324 0.782
R-HSA-5632684 Hedgehog 'on' state 0.288042 0.541
R-HSA-69481 G2/M Checkpoints 0.044429 1.352
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.194153 0.712
R-HSA-2467813 Separation of Sister Chromatids 0.231675 0.635
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.273147 0.564
R-HSA-75893 TNF signaling 0.056461 1.248
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.036048 1.443
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 0.058956 1.229
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.183093 0.737
R-HSA-418359 Reduction of cytosolic Ca++ levels 0.183093 0.737
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.226005 0.646
R-HSA-5576893 Phase 2 - plateau phase 0.246612 0.608
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.036858 1.433
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.276503 0.558
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.295772 0.529
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.295772 0.529
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.332789 0.478
R-HSA-69242 S Phase 0.075536 1.122
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.174852 0.757
R-HSA-157579 Telomere Maintenance 0.179584 0.746
R-HSA-5358351 Signaling by Hedgehog 0.347442 0.459
R-HSA-73886 Chromosome Maintenance 0.111006 0.955
R-HSA-9830674 Formation of the ureteric bud 0.058956 1.229
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.286202 0.543
R-HSA-6784531 tRNA processing in the nucleus 0.243349 0.614
R-HSA-4839726 Chromatin organization 0.073673 1.133
R-HSA-9758274 Regulation of NF-kappa B signaling 0.236378 0.626
R-HSA-1483249 Inositol phosphate metabolism 0.234804 0.629
R-HSA-69620 Cell Cycle Checkpoints 0.174979 0.757
R-HSA-9927353 Co-inhibition by BTLA 0.090036 1.046
R-HSA-70635 Urea cycle 0.069956 1.155
R-HSA-937039 IRAK1 recruits IKK complex 0.194038 0.712
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.194038 0.712
R-HSA-877312 Regulation of IFNG signaling 0.194038 0.712
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.215493 0.667
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.226005 0.646
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.305213 0.515
R-HSA-3238698 WNT ligand biogenesis and trafficking 0.314529 0.502
R-HSA-429947 Deadenylation of mRNA 0.332789 0.478
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.248310 0.605
R-HSA-8953854 Metabolism of RNA 0.182006 0.740
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.223557 0.651
R-HSA-180786 Extension of Telomeres 0.228495 0.641
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.094750 1.023
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.102222 0.990
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.102222 0.990
R-HSA-5362798 Release of Hh-Np from the secreting cell 0.102222 0.990
R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.102222 0.990
R-HSA-8964011 HDL clearance 0.114246 0.942
R-HSA-193692 Regulated proteolysis of p75NTR 0.149363 0.826
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.172000 0.764
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.172000 0.764
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.215493 0.667
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 0.226005 0.646
R-HSA-416482 G alpha (12/13) signalling events 0.029914 1.524
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.305213 0.515
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.314529 0.502
R-HSA-177929 Signaling by EGFR 0.213709 0.670
R-HSA-8943724 Regulation of PTEN gene transcription 0.233440 0.632
R-HSA-9018519 Estrogen-dependent gene expression 0.153359 0.814
R-HSA-8852135 Protein ubiquitination 0.307845 0.512
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.069774 1.156
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.266673 0.574
R-HSA-1474165 Reproduction 0.136215 0.866
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.141956 0.848
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.160596 0.794
R-HSA-397014 Muscle contraction 0.205285 0.688
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.102222 0.990
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.194038 0.712
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 0.194038 0.712
R-HSA-6807004 Negative regulation of MET activity 0.286202 0.543
R-HSA-912526 Interleukin receptor SHC signaling 0.323721 0.490
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.341737 0.466
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.263210 0.580
R-HSA-8939211 ESR-mediated signaling 0.266820 0.574
R-HSA-5617833 Cilium Assembly 0.153674 0.813
R-HSA-6794361 Neurexins and neuroligins 0.194153 0.712
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.305213 0.515
R-HSA-400685 Sema4D in semaphorin signaling 0.341737 0.466
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.137865 0.861
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.233440 0.632
R-HSA-3247509 Chromatin modifying enzymes 0.130751 0.884
R-HSA-5576891 Cardiac conduction 0.318138 0.497
R-HSA-68875 Mitotic Prophase 0.108827 0.963
R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family 0.090036 1.046
R-HSA-210990 PECAM1 interactions 0.172000 0.764
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.226005 0.646
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.233440 0.632
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.233440 0.632
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.233440 0.632
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.233440 0.632
R-HSA-69275 G2/M Transition 0.299396 0.524
R-HSA-453274 Mitotic G2-G2/M phases 0.305416 0.515
R-HSA-70171 Glycolysis 0.189663 0.722
R-HSA-446652 Interleukin-1 family signaling 0.198034 0.703
R-HSA-1433559 Regulation of KIT signaling 0.215493 0.667
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.276503 0.558
R-HSA-5687128 MAPK6/MAPK4 signaling 0.131773 0.880
R-HSA-68882 Mitotic Anaphase 0.042190 1.375
R-HSA-1169408 ISG15 antiviral mechanism 0.307845 0.512
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.042986 1.367
R-HSA-3214842 HDMs demethylate histones 0.341737 0.466
R-HSA-5578775 Ion homeostasis 0.213709 0.670
R-HSA-1852241 Organelle biogenesis and maintenance 0.177560 0.751
R-HSA-389948 Co-inhibition by PD-1 0.341755 0.466
R-HSA-432142 Platelet sensitization by LDL 0.266673 0.574
R-HSA-6802957 Oncogenic MAPK signaling 0.131773 0.880
R-HSA-982772 Growth hormone receptor signaling 0.058956 1.229
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.137814 0.861
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.149363 0.826
R-HSA-391160 Signal regulatory protein family interactions 0.215493 0.667
R-HSA-446353 Cell-extracellular matrix interactions 0.226005 0.646
R-HSA-2028269 Signaling by Hippo 0.256710 0.591
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.283080 0.548
R-HSA-983712 Ion channel transport 0.308431 0.511
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.233440 0.632
R-HSA-2672351 Stimuli-sensing channels 0.220693 0.656
R-HSA-8863678 Neurodegenerative Diseases 0.062551 1.204
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.062551 1.204
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.073761 1.132
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.119397 0.923
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.266673 0.574
R-HSA-9645723 Diseases of programmed cell death 0.144051 0.841
R-HSA-9830369 Kidney development 0.268179 0.572
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.069956 1.155
R-HSA-435354 Zinc transporters 0.215493 0.667
R-HSA-1980143 Signaling by NOTCH1 0.312781 0.505
R-HSA-70326 Glucose metabolism 0.259854 0.585
R-HSA-5633007 Regulation of TP53 Activity 0.220299 0.657
R-HSA-9008059 Interleukin-37 signaling 0.085555 1.068
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.119397 0.923
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.314529 0.502
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.283080 0.548
R-HSA-9700206 Signaling by ALK in cancer 0.078595 1.105
R-HSA-2262752 Cellular responses to stress 0.327382 0.485
R-HSA-3000170 Syndecan interactions 0.323721 0.490
R-HSA-186797 Signaling by PDGF 0.243349 0.614
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.078595 1.105
R-HSA-162582 Signal Transduction 0.273310 0.563
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.174852 0.757
R-HSA-9692914 SARS-CoV-1-host interactions 0.213705 0.670
R-HSA-3700989 Transcriptional Regulation by TP53 0.333418 0.477
R-HSA-1474228 Degradation of the extracellular matrix 0.321802 0.492
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.203534 0.691
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.111438 0.953
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.246612 0.608
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.288042 0.541
R-HSA-1433557 Signaling by SCF-KIT 0.151218 0.820
R-HSA-381119 Unfolded Protein Response (UPR) 0.061427 1.212
R-HSA-9833482 PKR-mediated signaling 0.332442 0.478
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.350565 0.455
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.307845 0.512
R-HSA-381038 XBP1(S) activates chaperone genes 0.040650 1.391
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.116982 0.932
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.213709 0.670
R-HSA-1266695 Interleukin-7 signaling 0.341737 0.466
R-HSA-1500931 Cell-Cell communication 0.170514 0.768
R-HSA-381070 IRE1alpha activates chaperones 0.048875 1.311
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.179584 0.746
R-HSA-447115 Interleukin-12 family signaling 0.041962 1.377
R-HSA-6794362 Protein-protein interactions at synapses 0.356788 0.448
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.359276 0.445
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.359276 0.445
R-HSA-8949613 Cristae formation 0.359276 0.445
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.365706 0.437
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.366439 0.436
R-HSA-167287 HIV elongation arrest and recovery 0.367870 0.434
R-HSA-167290 Pausing and recovery of HIV elongation 0.367870 0.434
R-HSA-171319 Telomere Extension By Telomerase 0.367870 0.434
R-HSA-5620971 Pyroptosis 0.367870 0.434
R-HSA-8856828 Clathrin-mediated endocytosis 0.369350 0.433
R-HSA-9679506 SARS-CoV Infections 0.373651 0.428
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.376349 0.424
R-HSA-418360 Platelet calcium homeostasis 0.376349 0.424
R-HSA-1236974 ER-Phagosome pathway 0.380811 0.419
R-HSA-9730414 MITF-M-regulated melanocyte development 0.384292 0.415
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.384715 0.415
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.384715 0.415
R-HSA-114452 Activation of BH3-only proteins 0.384715 0.415
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.384715 0.415
R-HSA-8986944 Transcriptional Regulation by MECP2 0.390315 0.409
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.392970 0.406
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.392970 0.406
R-HSA-2129379 Molecules associated with elastic fibres 0.392970 0.406
R-HSA-182971 EGFR downregulation 0.392970 0.406
R-HSA-186763 Downstream signal transduction 0.392970 0.406
R-HSA-9679191 Potential therapeutics for SARS 0.394741 0.404
R-HSA-69190 DNA strand elongation 0.401114 0.397
R-HSA-9675126 Diseases of mitotic cell cycle 0.401114 0.397
R-HSA-109582 Hemostasis 0.402094 0.396
R-HSA-8953897 Cellular responses to stimuli 0.404423 0.393
R-HSA-5693532 DNA Double-Strand Break Repair 0.405545 0.392
R-HSA-1855170 IPs transport between nucleus and cytosol 0.409149 0.388
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.409149 0.388
R-HSA-5083635 Defective B3GALTL causes PpS 0.409149 0.388
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.409149 0.388
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.409149 0.388
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.409149 0.388
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.409149 0.388
R-HSA-1839124 FGFR1 mutant receptor activation 0.409149 0.388
R-HSA-176187 Activation of ATR in response to replication stress 0.409149 0.388
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.409149 0.388
R-HSA-354192 Integrin signaling 0.409149 0.388
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.409149 0.388
R-HSA-1989781 PPARA activates gene expression 0.412717 0.384
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.413785 0.383
R-HSA-5693537 Resolution of D-Loop Structures 0.417077 0.380
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.417077 0.380
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.417077 0.380
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.417077 0.380
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.419862 0.377
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.424899 0.372
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.424899 0.372
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.424899 0.372
R-HSA-168638 NOD1/2 Signaling Pathway 0.424899 0.372
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 0.424899 0.372
R-HSA-5686938 Regulation of TLR by endogenous ligand 0.424899 0.372
R-HSA-180746 Nuclear import of Rev protein 0.424899 0.372
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.424899 0.372
R-HSA-9705683 SARS-CoV-2-host interactions 0.429501 0.367
R-HSA-9006936 Signaling by TGFB family members 0.430525 0.366
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.432236 0.364
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.432236 0.364
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.432236 0.364
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.432617 0.364
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.432617 0.364
R-HSA-381042 PERK regulates gene expression 0.432617 0.364
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.432617 0.364
R-HSA-3371511 HSF1 activation 0.440232 0.356
R-HSA-114604 GPVI-mediated activation cascade 0.440232 0.356
R-HSA-6804757 Regulation of TP53 Degradation 0.440232 0.356
R-HSA-5610787 Hedgehog 'off' state 0.441345 0.355
R-HSA-9020702 Interleukin-1 signaling 0.445870 0.351
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 0.447745 0.349
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.447745 0.349
R-HSA-5689896 Ovarian tumor domain proteases 0.447745 0.349
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.450374 0.346
R-HSA-1566948 Elastic fibre formation 0.455157 0.342
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.455157 0.342
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.455157 0.342
R-HSA-913531 Interferon Signaling 0.462463 0.335
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.462470 0.335
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.462470 0.335
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.462470 0.335
R-HSA-69541 Stabilization of p53 0.462470 0.335
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.462470 0.335
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.462470 0.335
R-HSA-8964043 Plasma lipoprotein clearance 0.462470 0.335
R-HSA-201556 Signaling by ALK 0.462470 0.335
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.463762 0.334
R-HSA-5619507 Activation of HOX genes during differentiation 0.463762 0.334
R-HSA-9833110 RSV-host interactions 0.463762 0.334
R-HSA-157118 Signaling by NOTCH 0.465048 0.333
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.468183 0.330
R-HSA-72306 tRNA processing 0.468984 0.329
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.469686 0.328
R-HSA-3371568 Attenuation phase 0.469686 0.328
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.469686 0.328
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.469686 0.328
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.469686 0.328
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.469686 0.328
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.469686 0.328
R-HSA-167169 HIV Transcription Elongation 0.469686 0.328
R-HSA-177243 Interactions of Rev with host cellular proteins 0.469686 0.328
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.469686 0.328
R-HSA-1251985 Nuclear signaling by ERBB4 0.469686 0.328
R-HSA-451927 Interleukin-2 family signaling 0.469686 0.328
R-HSA-418346 Platelet homeostasis 0.472581 0.326
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.475855 0.323
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.476805 0.322
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.476805 0.322
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.476805 0.322
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.476805 0.322
R-HSA-69239 Synthesis of DNA 0.476958 0.322
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.481313 0.318
R-HSA-1236975 Antigen processing-Cross presentation 0.481313 0.318
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.483830 0.315
R-HSA-5655302 Signaling by FGFR1 in disease 0.483830 0.315
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.483830 0.315
R-HSA-69002 DNA Replication Pre-Initiation 0.485645 0.314
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.485645 0.314
R-HSA-9678108 SARS-CoV-1 Infection 0.486085 0.313
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.489955 0.310
R-HSA-166166 MyD88-independent TLR4 cascade 0.489955 0.310
R-HSA-379716 Cytosolic tRNA aminoacylation 0.490760 0.309
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.490760 0.309
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.490760 0.309
R-HSA-9710421 Defective pyroptosis 0.497598 0.303
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.497598 0.303
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.502749 0.299
R-HSA-3214858 RMTs methylate histone arginines 0.504344 0.297
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.504344 0.297
R-HSA-449147 Signaling by Interleukins 0.506897 0.295
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.506968 0.295
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.511000 0.292
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.511000 0.292
R-HSA-774815 Nucleosome assembly 0.511000 0.292
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.511000 0.292
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.511000 0.292
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.511000 0.292
R-HSA-388841 Regulation of T cell activation by CD28 family 0.511162 0.291
R-HSA-1474244 Extracellular matrix organization 0.512406 0.290
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.515336 0.288
R-HSA-72165 mRNA Splicing - Minor Pathway 0.517567 0.286
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.517567 0.286
R-HSA-9675135 Diseases of DNA repair 0.517567 0.286
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.524046 0.281
R-HSA-1592230 Mitochondrial biogenesis 0.527711 0.278
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.529256 0.276
R-HSA-425410 Metal ion SLC transporters 0.530439 0.275
R-HSA-5693538 Homology Directed Repair 0.531788 0.274
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.535842 0.271
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.535842 0.271
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.536746 0.270
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.536746 0.270
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.536746 0.270
R-HSA-73893 DNA Damage Bypass 0.536746 0.270
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.547858 0.261
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.547858 0.261
R-HSA-3371571 HSF1-dependent transactivation 0.549109 0.260
R-HSA-1169091 Activation of NF-kappaB in B cells 0.549109 0.260
R-HSA-912446 Meiotic recombination 0.549109 0.260
R-HSA-5358346 Hedgehog ligand biogenesis 0.549109 0.260
R-HSA-112382 Formation of RNA Pol II elongation complex 0.555166 0.256
R-HSA-68949 Orc1 removal from chromatin 0.555166 0.256
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.555166 0.256
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.561143 0.251
R-HSA-69206 G1/S Transition 0.563539 0.249
R-HSA-9012852 Signaling by NOTCH3 0.572857 0.242
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.578597 0.238
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.584260 0.233
R-HSA-9006931 Signaling by Nuclear Receptors 0.589697 0.229
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.589848 0.229
R-HSA-9909396 Circadian clock 0.593725 0.226
R-HSA-429914 Deadenylation-dependent mRNA decay 0.595361 0.225
R-HSA-379724 tRNA Aminoacylation 0.600799 0.221
R-HSA-168325 Viral Messenger RNA Synthesis 0.606166 0.217
R-HSA-450294 MAP kinase activation 0.606166 0.217
R-HSA-1442490 Collagen degradation 0.606166 0.217
R-HSA-9707616 Heme signaling 0.611460 0.214
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.611460 0.214
R-HSA-5173105 O-linked glycosylation 0.615329 0.211
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.615329 0.211
R-HSA-69615 G1/S DNA Damage Checkpoints 0.616683 0.210
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.616683 0.210
R-HSA-373755 Semaphorin interactions 0.616683 0.210
R-HSA-8848021 Signaling by PTK6 0.616683 0.210
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.616683 0.210
R-HSA-1280215 Cytokine Signaling in Immune system 0.619220 0.208
R-HSA-5690714 CD22 mediated BCR regulation 0.621837 0.206
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.621837 0.206
R-HSA-936837 Ion transport by P-type ATPases 0.621837 0.206
R-HSA-6807070 PTEN Regulation 0.622333 0.206
R-HSA-195721 Signaling by WNT 0.622512 0.206
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.631938 0.199
R-HSA-162599 Late Phase of HIV Life Cycle 0.636046 0.197
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.636887 0.196
R-HSA-167172 Transcription of the HIV genome 0.641770 0.193
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.641770 0.193
R-HSA-5218859 Regulated Necrosis 0.641770 0.193
R-HSA-8878171 Transcriptional regulation by RUNX1 0.645605 0.190
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.649368 0.188
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.651342 0.186
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.651342 0.186
R-HSA-448424 Interleukin-17 signaling 0.651342 0.186
R-HSA-204005 COPII-mediated vesicle transport 0.651342 0.186
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.655883 0.183
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.656031 0.183
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.656031 0.183
R-HSA-5578749 Transcriptional regulation by small RNAs 0.660658 0.180
R-HSA-72312 rRNA processing 0.661594 0.179
R-HSA-9856651 MITF-M-dependent gene expression 0.662301 0.179
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.665223 0.177
R-HSA-69052 Switching of origins to a post-replicative state 0.665223 0.177
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.665475 0.177
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.669727 0.174
R-HSA-1226099 Signaling by FGFR in disease 0.669727 0.174
R-HSA-1236394 Signaling by ERBB4 0.669727 0.174
R-HSA-69306 DNA Replication 0.671749 0.173
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.674170 0.171
R-HSA-74160 Gene expression (Transcription) 0.676337 0.170
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.678554 0.168
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.682879 0.166
R-HSA-162587 HIV Life Cycle 0.684014 0.165
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.687021 0.163
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.687146 0.163
R-HSA-4086400 PCP/CE pathway 0.687146 0.163
R-HSA-73864 RNA Polymerase I Transcription 0.687146 0.163
R-HSA-216083 Integrin cell surface interactions 0.687146 0.163
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.691357 0.160
R-HSA-5654738 Signaling by FGFR2 0.695510 0.158
R-HSA-6806834 Signaling by MET 0.695510 0.158
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.699608 0.155
R-HSA-9707564 Cytoprotection by HMOX1 0.707641 0.150
R-HSA-73857 RNA Polymerase II Transcription 0.710485 0.148
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.711576 0.148
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.719290 0.143
R-HSA-141424 Amplification of signal from the kinetochores 0.719290 0.143
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.719290 0.143
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.724016 0.140
R-HSA-438064 Post NMDA receptor activation events 0.726798 0.139
R-HSA-390466 Chaperonin-mediated protein folding 0.726798 0.139
R-HSA-5683057 MAPK family signaling cascades 0.730469 0.136
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.732012 0.135
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.732012 0.135
R-HSA-9694516 SARS-CoV-2 Infection 0.734342 0.134
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.737234 0.132
R-HSA-202424 Downstream TCR signaling 0.737687 0.132
R-HSA-112310 Neurotransmitter release cycle 0.737687 0.132
R-HSA-9711123 Cellular response to chemical stress 0.746573 0.127
R-HSA-156842 Eukaryotic Translation Elongation 0.748144 0.126
R-HSA-391251 Protein folding 0.748144 0.126
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.748144 0.126
R-HSA-2559583 Cellular Senescence 0.749912 0.125
R-HSA-68867 Assembly of the pre-replicative complex 0.751537 0.124
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.751537 0.124
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.753814 0.123
R-HSA-1474290 Collagen formation 0.754884 0.122
R-HSA-73894 DNA Repair 0.754901 0.122
R-HSA-201681 TCF dependent signaling in response to WNT 0.757264 0.121
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.764658 0.117
R-HSA-446728 Cell junction organization 0.766931 0.115
R-HSA-190236 Signaling by FGFR 0.770958 0.113
R-HSA-9614085 FOXO-mediated transcription 0.774045 0.111
R-HSA-168898 Toll-like Receptor Cascades 0.775968 0.110
R-HSA-69618 Mitotic Spindle Checkpoint 0.777090 0.110
R-HSA-1483255 PI Metabolism 0.783059 0.106
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.787010 0.104
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.788868 0.103
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.788868 0.103
R-HSA-9860931 Response of endothelial cells to shear stress 0.788868 0.103
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.791714 0.101
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.795497 0.099
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.800026 0.097
R-HSA-211000 Gene Silencing by RNA 0.800026 0.097
R-HSA-199991 Membrane Trafficking 0.800388 0.097
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.805383 0.094
R-HSA-202403 TCR signaling 0.808008 0.093
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.813152 0.090
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.813152 0.090
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.815672 0.088
R-HSA-9855142 Cellular responses to mechanical stimuli 0.818159 0.087
R-HSA-597592 Post-translational protein modification 0.820011 0.086
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.821059 0.086
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.823032 0.085
R-HSA-909733 Interferon alpha/beta signaling 0.825420 0.083
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.825420 0.083
R-HSA-418990 Adherens junctions interactions 0.831865 0.080
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.839088 0.076
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.843402 0.074
R-HSA-162909 Host Interactions of HIV factors 0.845516 0.073
R-HSA-162906 HIV Infection 0.846978 0.072
R-HSA-194138 Signaling by VEGF 0.849660 0.071
R-HSA-9824446 Viral Infection Pathways 0.854013 0.069
R-HSA-3858494 Beta-catenin independent WNT signaling 0.874022 0.058
R-HSA-5653656 Vesicle-mediated transport 0.874149 0.058
R-HSA-421270 Cell-cell junction organization 0.881445 0.055
R-HSA-2871837 FCERI mediated NF-kB activation 0.888544 0.051
R-HSA-199977 ER to Golgi Anterograde Transport 0.893005 0.049
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.897287 0.047
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.900047 0.046
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.904049 0.044
R-HSA-9610379 HCMV Late Events 0.906628 0.043
R-HSA-9711097 Cellular response to starvation 0.907892 0.042
R-HSA-212436 Generic Transcription Pathway 0.908077 0.042
R-HSA-877300 Interferon gamma signaling 0.909138 0.041
R-HSA-2408522 Selenoamino acid metabolism 0.915123 0.039
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.915400 0.038
R-HSA-5619102 SLC transporter disorders 0.918524 0.037
R-HSA-5621481 C-type lectin receptors (CLRs) 0.923893 0.034
R-HSA-9664433 Leishmania parasite growth and survival 0.925941 0.033
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.925941 0.033
R-HSA-5689880 Ub-specific processing proteases 0.925941 0.033
R-HSA-1257604 PIP3 activates AKT signaling 0.926734 0.033
R-HSA-168255 Influenza Infection 0.931761 0.031
R-HSA-3781865 Diseases of glycosylation 0.936261 0.029
R-HSA-72766 Translation 0.943257 0.025
R-HSA-9609690 HCMV Early Events 0.945894 0.024
R-HSA-112315 Transmission across Chemical Synapses 0.946478 0.024
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.948771 0.023
R-HSA-948021 Transport to the Golgi and subsequent modification 0.950151 0.022
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.950828 0.022
R-HSA-376176 Signaling by ROBO receptors 0.950828 0.022
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.956358 0.019
R-HSA-9006925 Intracellular signaling by second messengers 0.956878 0.019
R-HSA-112316 Neuronal System 0.961796 0.017
R-HSA-1643685 Disease 0.965485 0.015
R-HSA-202733 Cell surface interactions at the vascular wall 0.969536 0.013
R-HSA-5619115 Disorders of transmembrane transporters 0.973436 0.012
R-HSA-9609646 HCMV Infection 0.974506 0.011
R-HSA-5688426 Deubiquitination 0.976195 0.010
R-HSA-1280218 Adaptive Immune System 0.977822 0.010
R-HSA-392499 Metabolism of proteins 0.978129 0.010
R-HSA-9824443 Parasitic Infection Pathways 0.983337 0.007
R-HSA-9658195 Leishmania infection 0.983337 0.007
R-HSA-5673001 RAF/MAP kinase cascade 0.985071 0.007
R-HSA-1266738 Developmental Biology 0.985529 0.006
R-HSA-1483257 Phospholipid metabolism 0.986253 0.006
R-HSA-5684996 MAPK1/MAPK3 signaling 0.986441 0.006
R-HSA-5663205 Infectious disease 0.987265 0.006
R-HSA-168249 Innate Immune System 0.988938 0.005
R-HSA-8957322 Metabolism of steroids 0.990775 0.004
R-HSA-71291 Metabolism of amino acids and derivatives 0.992364 0.003
R-HSA-382551 Transport of small molecules 0.993584 0.003
R-HSA-388396 GPCR downstream signalling 0.994741 0.002
R-HSA-168256 Immune System 0.996161 0.002
R-HSA-422475 Axon guidance 0.996220 0.002
R-HSA-9824439 Bacterial Infection Pathways 0.996341 0.002
R-HSA-425407 SLC-mediated transmembrane transport 0.996678 0.001
R-HSA-9675108 Nervous system development 0.997611 0.001
R-HSA-446203 Asparagine N-linked glycosylation 0.997650 0.001
R-HSA-5668914 Diseases of metabolism 0.997807 0.001
R-HSA-372790 Signaling by GPCR 0.997849 0.001
R-HSA-556833 Metabolism of lipids 0.999999 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
FAM20CFAM20C 0.875 0.576 2 0.874
COTCOT 0.874 0.151 2 0.742
CLK3CLK3 0.868 0.231 1 0.898
DSTYKDSTYK 0.862 0.160 2 0.776
NLKNLK 0.856 0.090 1 0.892
PRPKPRPK 0.856 -0.018 -1 0.838
CAMK2GCAMK2G 0.853 0.058 2 0.695
MTORMTOR 0.853 -0.036 1 0.846
GCN2GCN2 0.853 -0.095 2 0.647
IKKBIKKB 0.852 -0.013 -2 0.737
PKN3PKN3 0.852 0.054 -3 0.847
ULK2ULK2 0.851 -0.087 2 0.651
MOSMOS 0.851 0.011 1 0.886
NEK6NEK6 0.851 0.018 -2 0.869
CDC7CDC7 0.850 -0.049 1 0.852
PIM3PIM3 0.850 0.006 -3 0.853
RAF1RAF1 0.850 -0.060 1 0.864
TBK1TBK1 0.849 -0.026 1 0.775
PDHK4PDHK4 0.849 -0.078 1 0.886
BMPR2BMPR2 0.849 0.009 -2 0.882
ATRATR 0.849 0.041 1 0.881
CDKL1CDKL1 0.849 0.032 -3 0.822
CAMK1BCAMK1B 0.849 -0.016 -3 0.882
MLK1MLK1 0.848 -0.001 2 0.713
NEK7NEK7 0.848 -0.029 -3 0.879
PKCDPKCD 0.847 0.062 2 0.687
MARK4MARK4 0.847 0.054 4 0.866
ERK5ERK5 0.847 0.034 1 0.856
MST4MST4 0.845 0.011 2 0.720
IKKEIKKE 0.845 -0.047 1 0.771
TGFBR2TGFBR2 0.845 -0.001 -2 0.817
NIKNIK 0.844 -0.038 -3 0.905
WNK1WNK1 0.844 -0.003 -2 0.892
CHAK2CHAK2 0.844 -0.007 -1 0.851
NDR2NDR2 0.844 -0.050 -3 0.861
IKKAIKKA 0.843 0.064 -2 0.723
ULK1ULK1 0.843 -0.112 -3 0.862
PDHK1PDHK1 0.843 -0.153 1 0.871
SRPK1SRPK1 0.842 0.076 -3 0.762
CDKL5CDKL5 0.842 0.018 -3 0.813
SKMLCKSKMLCK 0.842 0.048 -2 0.871
MLK3MLK3 0.840 0.035 2 0.667
PIM1PIM1 0.840 0.038 -3 0.789
GRK1GRK1 0.840 0.069 -2 0.752
PKN2PKN2 0.840 -0.027 -3 0.852
WNK3WNK3 0.840 -0.118 1 0.854
CDK8CDK8 0.840 0.081 1 0.743
CAMLCKCAMLCK 0.839 -0.006 -2 0.858
RIPK3RIPK3 0.839 -0.081 3 0.747
ATMATM 0.839 0.097 1 0.827
NUAK2NUAK2 0.839 -0.042 -3 0.849
CAMK2BCAMK2B 0.839 0.124 2 0.714
BMPR1BBMPR1B 0.839 0.157 1 0.780
HUNKHUNK 0.839 -0.116 2 0.627
PRKD1PRKD1 0.838 -0.032 -3 0.843
RSK2RSK2 0.838 0.006 -3 0.783
CAMK2DCAMK2D 0.838 0.022 -3 0.863
ICKICK 0.838 0.021 -3 0.857
KISKIS 0.838 0.059 1 0.776
DAPK2DAPK2 0.837 -0.027 -3 0.890
NDR1NDR1 0.837 -0.072 -3 0.852
GRK6GRK6 0.837 -0.003 1 0.854
TSSK2TSSK2 0.836 -0.017 -5 0.697
LATS1LATS1 0.836 0.118 -3 0.883
TGFBR1TGFBR1 0.836 0.134 -2 0.837
HIPK4HIPK4 0.836 0.010 1 0.851
PRKD2PRKD2 0.836 -0.011 -3 0.777
MAPKAPK3MAPKAPK3 0.836 -0.033 -3 0.794
BCKDKBCKDK 0.836 -0.105 -1 0.769
NEK9NEK9 0.836 -0.109 2 0.687
AMPKA1AMPKA1 0.836 -0.047 -3 0.868
MLK4MLK4 0.835 0.019 2 0.653
CDK5CDK5 0.835 0.113 1 0.771
ANKRD3ANKRD3 0.835 -0.077 1 0.883
P90RSKP90RSK 0.835 -0.025 -3 0.789
SRPK2SRPK2 0.835 0.062 -3 0.684
PKCBPKCB 0.835 0.017 2 0.659
LATS2LATS2 0.835 -0.037 -5 0.678
GRK5GRK5 0.835 -0.148 -3 0.891
MLK2MLK2 0.834 -0.098 2 0.691
TSSK1TSSK1 0.834 -0.006 -3 0.884
CDK1CDK1 0.834 0.124 1 0.711
ALK4ALK4 0.834 0.061 -2 0.861
MAPKAPK2MAPKAPK2 0.834 0.023 -3 0.743
P70S6KBP70S6KB 0.834 -0.034 -3 0.812
ALK2ALK2 0.833 0.165 -2 0.839
PKRPKR 0.833 0.018 1 0.863
IRE2IRE2 0.832 -0.040 2 0.651
RSK3RSK3 0.832 -0.029 -3 0.782
CDK19CDK19 0.832 0.068 1 0.702
DLKDLK 0.832 -0.125 1 0.851
PKCGPKCG 0.832 -0.012 2 0.651
PKCAPKCA 0.832 0.011 2 0.648
IRE1IRE1 0.832 -0.091 1 0.812
CLK4CLK4 0.831 0.077 -3 0.774
CLK1CLK1 0.831 0.088 -3 0.749
PLK1PLK1 0.831 -0.026 -2 0.795
NIM1NIM1 0.831 -0.096 3 0.801
PKACGPKACG 0.831 -0.021 -2 0.754
QSKQSK 0.830 0.013 4 0.853
MARK2MARK2 0.830 0.056 4 0.785
CLK2CLK2 0.830 0.137 -3 0.753
PKCHPKCH 0.830 -0.012 2 0.641
AURCAURC 0.829 0.024 -2 0.683
AMPKA2AMPKA2 0.829 -0.044 -3 0.832
CDK2CDK2 0.829 0.088 1 0.790
JNK3JNK3 0.829 0.100 1 0.743
MARK3MARK3 0.829 0.042 4 0.822
DYRK2DYRK2 0.828 0.069 1 0.769
SRPK3SRPK3 0.828 0.033 -3 0.737
SMG1SMG1 0.828 0.060 1 0.834
QIKQIK 0.828 -0.078 -3 0.855
MASTLMASTL 0.828 -0.263 -2 0.812
ACVR2AACVR2A 0.828 0.060 -2 0.803
CAMK2ACAMK2A 0.828 0.015 2 0.684
CHAK1CHAK1 0.828 -0.077 2 0.607
TTBK2TTBK2 0.827 -0.183 2 0.565
ACVR2BACVR2B 0.827 0.072 -2 0.809
PLK3PLK3 0.827 0.014 2 0.646
PKCZPKCZ 0.827 -0.027 2 0.662
NEK2NEK2 0.827 -0.084 2 0.668
CAMK4CAMK4 0.827 -0.098 -3 0.833
MSK2MSK2 0.827 -0.020 -3 0.759
YSK4YSK4 0.827 -0.078 1 0.797
NUAK1NUAK1 0.827 -0.058 -3 0.805
MELKMELK 0.827 -0.065 -3 0.819
DNAPKDNAPK 0.826 0.091 1 0.790
SIKSIK 0.826 -0.012 -3 0.779
CDK13CDK13 0.826 0.058 1 0.731
BRSK1BRSK1 0.826 -0.022 -3 0.807
JNK2JNK2 0.826 0.101 1 0.702
PAK1PAK1 0.826 -0.044 -2 0.785
RSK4RSK4 0.826 0.018 -3 0.748
PHKG1PHKG1 0.826 -0.066 -3 0.839
RIPK1RIPK1 0.825 -0.168 1 0.839
GRK4GRK4 0.825 -0.108 -2 0.803
CDK7CDK7 0.825 0.032 1 0.754
GRK7GRK7 0.825 0.058 1 0.805
BMPR1ABMPR1A 0.825 0.151 1 0.761
P38AP38A 0.825 0.076 1 0.783
MNK2MNK2 0.825 -0.028 -2 0.815
AURBAURB 0.825 0.017 -2 0.680
CDK3CDK3 0.824 0.137 1 0.654
CDK18CDK18 0.824 0.071 1 0.686
MEK1MEK1 0.824 -0.128 2 0.685
PRKD3PRKD3 0.824 -0.038 -3 0.754
PAK3PAK3 0.824 -0.081 -2 0.784
MARK1MARK1 0.824 0.018 4 0.839
ERK2ERK2 0.824 0.060 1 0.756
ERK1ERK1 0.824 0.076 1 0.709
VRK2VRK2 0.822 -0.180 1 0.895
MSK1MSK1 0.822 0.018 -3 0.767
P38GP38G 0.822 0.091 1 0.630
MYLK4MYLK4 0.822 -0.002 -2 0.779
ERK7ERK7 0.822 0.061 2 0.513
MNK1MNK1 0.822 -0.026 -2 0.815
TLK2TLK2 0.821 -0.029 1 0.839
PKACBPKACB 0.821 0.029 -2 0.695
BRSK2BRSK2 0.821 -0.071 -3 0.833
PINK1PINK1 0.821 -0.051 1 0.864
AURAAURA 0.820 0.033 -2 0.652
CHK1CHK1 0.820 -0.062 -3 0.852
P38BP38B 0.820 0.085 1 0.721
SGK3SGK3 0.820 -0.010 -3 0.775
CDK17CDK17 0.820 0.067 1 0.637
DRAK1DRAK1 0.819 -0.063 1 0.792
PERKPERK 0.819 -0.114 -2 0.839
CDK12CDK12 0.818 0.051 1 0.708
HIPK1HIPK1 0.818 0.059 1 0.780
PRKXPRKX 0.818 0.053 -3 0.676
NEK5NEK5 0.818 -0.050 1 0.859
PKG2PKG2 0.818 -0.012 -2 0.694
PAK2PAK2 0.818 -0.079 -2 0.772
AKT2AKT2 0.817 0.005 -3 0.691
PLK4PLK4 0.817 -0.101 2 0.492
SNRKSNRK 0.817 -0.173 2 0.555
HRIHRI 0.817 -0.134 -2 0.850
CAMK1GCAMK1G 0.817 -0.051 -3 0.771
BRAFBRAF 0.817 -0.053 -4 0.867
PKCTPKCT 0.817 -0.022 2 0.643
CDK16CDK16 0.817 0.089 1 0.656
CDK9CDK9 0.817 0.025 1 0.737
MEKK2MEKK2 0.816 -0.069 2 0.676
WNK4WNK4 0.816 -0.077 -2 0.894
PIM2PIM2 0.816 -0.014 -3 0.757
SSTKSSTK 0.816 -0.015 4 0.839
PRP4PRP4 0.816 0.032 -3 0.787
DCAMKL1DCAMKL1 0.816 -0.044 -3 0.791
MEKK1MEKK1 0.815 -0.113 1 0.835
ZAKZAK 0.815 -0.114 1 0.803
MEKK3MEKK3 0.815 -0.135 1 0.820
DYRK1ADYRK1A 0.815 0.031 1 0.820
PAK6PAK6 0.815 -0.037 -2 0.720
HIPK2HIPK2 0.815 0.072 1 0.686
PHKG2PHKG2 0.815 -0.057 -3 0.804
CDK14CDK14 0.814 0.055 1 0.726
NEK8NEK8 0.814 -0.051 2 0.686
MEK5MEK5 0.814 -0.213 2 0.683
IRAK4IRAK4 0.813 -0.113 1 0.822
TAO3TAO3 0.813 -0.013 1 0.828
MST3MST3 0.813 -0.044 2 0.695
P38DP38D 0.813 0.096 1 0.651
MAPKAPK5MAPKAPK5 0.812 -0.100 -3 0.739
DYRK4DYRK4 0.812 0.079 1 0.700
AKT1AKT1 0.812 0.018 -3 0.709
GRK2GRK2 0.811 -0.066 -2 0.705
TLK1TLK1 0.811 -0.090 -2 0.825
HIPK3HIPK3 0.811 0.021 1 0.789
DCAMKL2DCAMKL2 0.811 -0.062 -3 0.817
SMMLCKSMMLCK 0.810 -0.040 -3 0.834
CDK10CDK10 0.809 0.063 1 0.711
PKCIPKCI 0.809 -0.039 2 0.649
DYRK1BDYRK1B 0.809 0.052 1 0.730
DYRK3DYRK3 0.808 0.045 1 0.779
PKCEPKCE 0.808 0.006 2 0.639
TAO2TAO2 0.807 -0.058 2 0.713
EEF2KEEF2K 0.807 -0.010 3 0.874
CAMK1DCAMK1D 0.807 -0.012 -3 0.691
CAMKK1CAMKK1 0.807 -0.103 -2 0.753
PASKPASK 0.807 -0.036 -3 0.869
MST2MST2 0.806 -0.020 1 0.827
GAKGAK 0.806 -0.017 1 0.838
PKACAPKACA 0.806 0.012 -2 0.650
CDK6CDK6 0.805 0.073 1 0.707
TNIKTNIK 0.804 0.024 3 0.886
TAK1TAK1 0.804 -0.015 1 0.859
P70S6KP70S6K 0.803 -0.075 -3 0.723
GCKGCK 0.803 -0.017 1 0.824
NEK11NEK11 0.803 -0.167 1 0.832
TTBK1TTBK1 0.803 -0.177 2 0.499
DAPK3DAPK3 0.802 0.007 -3 0.809
PLK2PLK2 0.802 0.028 -3 0.826
CK1ECK1E 0.802 -0.075 -3 0.536
PDK1PDK1 0.801 -0.071 1 0.859
HGKHGK 0.801 -0.038 3 0.880
CK2A2CK2A2 0.801 0.067 1 0.697
MINKMINK 0.801 -0.020 1 0.816
JNK1JNK1 0.801 0.060 1 0.694
GSK3AGSK3A 0.801 -0.013 4 0.390
CAMKK2CAMKK2 0.800 -0.133 -2 0.758
IRAK1IRAK1 0.800 -0.200 -1 0.743
CDK4CDK4 0.800 0.058 1 0.696
PKN1PKN1 0.799 -0.037 -3 0.734
MPSK1MPSK1 0.799 -0.090 1 0.788
NEK4NEK4 0.799 -0.134 1 0.817
GSK3BGSK3B 0.799 -0.059 4 0.380
LRRK2LRRK2 0.797 -0.130 2 0.694
MEKK6MEKK6 0.797 -0.151 1 0.821
MST1MST1 0.797 -0.061 1 0.816
LKB1LKB1 0.796 -0.156 -3 0.866
MAP3K15MAP3K15 0.796 -0.132 1 0.799
VRK1VRK1 0.796 -0.095 2 0.674
LOKLOK 0.795 -0.087 -2 0.770
NEK1NEK1 0.795 -0.110 1 0.830
GRK3GRK3 0.795 -0.069 -2 0.662
HPK1HPK1 0.795 -0.051 1 0.809
KHS2KHS2 0.795 0.021 1 0.823
AKT3AKT3 0.795 0.002 -3 0.624
DAPK1DAPK1 0.794 -0.014 -3 0.788
KHS1KHS1 0.794 -0.012 1 0.811
CAMK1ACAMK1A 0.794 -0.026 -3 0.655
SLKSLK 0.794 -0.069 -2 0.706
MAKMAK 0.793 0.060 -2 0.732
SGK1SGK1 0.793 0.002 -3 0.610
PAK5PAK5 0.793 -0.074 -2 0.656
MRCKBMRCKB 0.793 -0.009 -3 0.747
PDHK3_TYRPDHK3_TYR 0.792 0.090 4 0.876
CK1DCK1D 0.792 -0.065 -3 0.485
ROCK2ROCK2 0.792 -0.004 -3 0.799
MOKMOK 0.791 0.035 1 0.785
MRCKAMRCKA 0.791 -0.024 -3 0.766
CHK2CHK2 0.791 -0.046 -3 0.632
YSK1YSK1 0.791 -0.093 2 0.676
CK1G1CK1G1 0.790 -0.112 -3 0.545
CK2A1CK2A1 0.790 0.042 1 0.675
STK33STK33 0.789 -0.166 2 0.498
OSR1OSR1 0.788 -0.018 2 0.661
PAK4PAK4 0.788 -0.071 -2 0.665
PDHK4_TYRPDHK4_TYR 0.787 0.071 2 0.725
MEK2MEK2 0.786 -0.217 2 0.649
RIPK2RIPK2 0.786 -0.216 1 0.767
BUB1BUB1 0.786 -0.032 -5 0.661
TTKTTK 0.786 -0.022 -2 0.817
CK1A2CK1A2 0.786 -0.089 -3 0.480
TESK1_TYRTESK1_TYR 0.785 -0.062 3 0.899
ALPHAK3ALPHAK3 0.784 0.061 -1 0.764
NEK3NEK3 0.783 -0.151 1 0.797
PDHK1_TYRPDHK1_TYR 0.783 0.031 -1 0.877
SBKSBK 0.783 -0.016 -3 0.565
BMPR2_TYRBMPR2_TYR 0.782 0.031 -1 0.848
MAP2K6_TYRMAP2K6_TYR 0.782 0.002 -1 0.852
MAP2K7_TYRMAP2K7_TYR 0.781 -0.143 2 0.704
DMPK1DMPK1 0.781 -0.003 -3 0.758
ROCK1ROCK1 0.781 -0.012 -3 0.761
MYO3BMYO3B 0.781 -0.043 2 0.690
PINK1_TYRPINK1_TYR 0.781 -0.093 1 0.870
MAP2K4_TYRMAP2K4_TYR 0.780 -0.103 -1 0.852
PKG1PKG1 0.780 -0.039 -2 0.623
PBKPBK 0.779 -0.106 1 0.762
EPHA6EPHA6 0.779 0.027 -1 0.864
MYO3AMYO3A 0.778 -0.050 1 0.806
HASPINHASPIN 0.778 -0.039 -1 0.685
LIMK2_TYRLIMK2_TYR 0.777 -0.067 -3 0.919
PKMYT1_TYRPKMYT1_TYR 0.777 -0.156 3 0.854
RETRET 0.776 -0.052 1 0.846
TAO1TAO1 0.776 -0.084 1 0.761
ASK1ASK1 0.775 -0.140 1 0.785
EPHB4EPHB4 0.775 0.014 -1 0.854
TYK2TYK2 0.773 -0.111 1 0.843
TYRO3TYRO3 0.773 -0.044 3 0.802
BIKEBIKE 0.773 -0.035 1 0.698
TXKTXK 0.773 0.106 1 0.819
ROS1ROS1 0.772 -0.076 3 0.774
CRIKCRIK 0.772 -0.033 -3 0.710
LIMK1_TYRLIMK1_TYR 0.772 -0.169 2 0.706
YES1YES1 0.771 0.028 -1 0.847
ABL2ABL2 0.770 0.029 -1 0.805
YANK3YANK3 0.770 -0.095 2 0.334
CSF1RCSF1R 0.770 -0.040 3 0.781
MST1RMST1R 0.770 -0.120 3 0.801
INSRRINSRR 0.769 0.016 3 0.750
JAK2JAK2 0.769 -0.109 1 0.843
JAK3JAK3 0.768 -0.064 1 0.827
LCKLCK 0.768 0.058 -1 0.838
BLKBLK 0.768 0.086 -1 0.849
HCKHCK 0.767 0.019 -1 0.839
FERFER 0.767 -0.027 1 0.878
DDR1DDR1 0.767 -0.103 4 0.796
EPHA4EPHA4 0.766 0.004 2 0.647
ITKITK 0.765 0.005 -1 0.808
FGRFGR 0.765 -0.072 1 0.853
SRMSSRMS 0.764 0.017 1 0.850
STLK3STLK3 0.764 -0.159 1 0.770
EPHB1EPHB1 0.764 -0.023 1 0.849
FGFR2FGFR2 0.764 -0.055 3 0.790
FLT3FLT3 0.764 -0.060 3 0.789
EPHB3EPHB3 0.763 -0.016 -1 0.844
ABL1ABL1 0.763 -0.036 -1 0.795
PDGFRBPDGFRB 0.763 -0.101 3 0.804
TECTEC 0.763 0.017 -1 0.771
NEK10_TYRNEK10_TYR 0.762 -0.076 1 0.736
EPHB2EPHB2 0.762 0.012 -1 0.837
KITKIT 0.761 -0.071 3 0.783
TEKTEK 0.761 -0.072 3 0.731
KDRKDR 0.760 -0.094 3 0.747
TNNI3K_TYRTNNI3K_TYR 0.760 -0.097 1 0.829
TNK2TNK2 0.759 -0.084 3 0.741
BTKBTK 0.759 -0.040 -1 0.787
MERTKMERTK 0.759 -0.010 3 0.761
BMXBMX 0.759 0.002 -1 0.753
JAK1JAK1 0.758 -0.092 1 0.784
FYNFYN 0.758 0.065 -1 0.815
FGFR1FGFR1 0.758 -0.107 3 0.761
AXLAXL 0.758 -0.074 3 0.766
TNK1TNK1 0.757 -0.128 3 0.775
WEE1_TYRWEE1_TYR 0.757 -0.078 -1 0.751
EPHA7EPHA7 0.757 -0.012 2 0.650
FRKFRK 0.755 -0.028 -1 0.864
LTKLTK 0.754 -0.077 3 0.729
FGFR3FGFR3 0.754 -0.065 3 0.763
PDGFRAPDGFRA 0.754 -0.191 3 0.800
ALKALK 0.754 -0.110 3 0.710
AAK1AAK1 0.753 -0.016 1 0.592
METMET 0.753 -0.105 3 0.769
LYNLYN 0.753 -0.001 3 0.699
FLT1FLT1 0.753 -0.096 -1 0.816
EPHA5EPHA5 0.752 0.022 2 0.649
ERBB2ERBB2 0.751 -0.102 1 0.800
EPHA3EPHA3 0.751 -0.086 2 0.619
EPHA1EPHA1 0.751 -0.070 3 0.744
NTRK1NTRK1 0.751 -0.122 -1 0.798
PTK6PTK6 0.751 -0.158 -1 0.721
INSRINSR 0.750 -0.085 3 0.723
DDR2DDR2 0.749 -0.035 3 0.730
FLT4FLT4 0.748 -0.150 3 0.743
EPHA8EPHA8 0.748 -0.019 -1 0.827
NTRK2NTRK2 0.748 -0.148 3 0.745
EGFREGFR 0.747 -0.010 1 0.709
MATKMATK 0.746 -0.090 -1 0.730
CK1ACK1A 0.745 -0.118 -3 0.390
SRCSRC 0.744 -0.036 -1 0.811
NTRK3NTRK3 0.744 -0.101 -1 0.756
PTK2BPTK2B 0.743 -0.070 -1 0.783
PTK2PTK2 0.743 0.003 -1 0.774
FGFR4FGFR4 0.743 -0.034 -1 0.764
CSKCSK 0.741 -0.105 2 0.643
SYKSYK 0.740 0.013 -1 0.775
EPHA2EPHA2 0.738 -0.028 -1 0.793
YANK2YANK2 0.738 -0.112 2 0.367
CK1G3CK1G3 0.736 -0.084 -3 0.342
IGF1RIGF1R 0.736 -0.084 3 0.659
MUSKMUSK 0.735 -0.126 1 0.703
ERBB4ERBB4 0.729 -0.031 1 0.709
FESFES 0.717 -0.132 -1 0.716
ZAP70ZAP70 0.716 -0.049 -1 0.690
CK1G2CK1G2 0.716 -0.086 -3 0.448