Motif 747 (n=165)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NDB9 | PALM3 | S260 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| A8TX70 | COL6A5 | S2255 | ochoa | Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S168 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00180 | KCNK1 | S302 | ochoa | Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1) | Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086, PubMed:8605869, PubMed:8978667). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478). Permeable to monovalent cations with ion selectivity for K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+). {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:19959478, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667}. |
| O00472 | ELL2 | S502 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
| O15042 | U2SURP | Y117 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15056 | SYNJ2 | S1191 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O15061 | SYNM | S1132 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43314 | PPIP5K2 | S916 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43491 | EPB41L2 | S647 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43823 | AKAP8 | S328 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
| O60271 | SPAG9 | S311 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60662 | KLHL41 | S244 | ochoa | Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9}. |
| O75400 | PRPF40A | S787 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O75563 | SKAP2 | S223 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O94874 | UFL1 | S413 | ochoa | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) | E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:27351204, PubMed:30626644, PubMed:30783677, PubMed:32160526, PubMed:32807901, PubMed:35394863, PubMed:36121123, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37311461, PubMed:37595036, PubMed:37795761, PubMed:38377992, PubMed:38383785, PubMed:38383789). Catalyzes ufmylation of many protein, such as CD274/PD-L1, CDK5RAP3, CYB5R3, DDRGK1, EIF6, histone H4, MRE11, P4HB, PDCD1/PD-1, TRIP4, RPN1, RPS20/uS10, RPL10/uL16, RPL26/uL24, SYVN1/HRD1 and TP53/p53 (PubMed:20018847, PubMed:20531390, PubMed:25219498, PubMed:30783677, PubMed:30886146, PubMed:32160526, PubMed:35753586, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37595036, PubMed:37795761, PubMed:38383785, PubMed:38383789). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (PubMed:37036982, PubMed:37595036, PubMed:38383785, PubMed:38383789). Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (PubMed:23152784, PubMed:32160526, PubMed:36543799). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:32050156). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is, a collateral effect or is required for ufmylation (PubMed:20018847, PubMed:20531390). Acts as a negative regulator of T-cell activation by mediating ufmylation and stabilization of PDCD1/PD-1 (PubMed:38377992). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 and ufmylation of MRE11 (PubMed:30783677, PubMed:30886146). Mediates ufmylation of TP53/p53, promoting its stability (PubMed:32807901). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (PubMed:25219498). Required for hematopoietic stem cell function and hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CCJ3, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:20531390, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:27351204, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:30783677, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:32050156, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:32807901, ECO:0000269|PubMed:35394863, ECO:0000269|PubMed:35753586, ECO:0000269|PubMed:36121123, ECO:0000269|PubMed:36543799, ECO:0000269|PubMed:36893266, ECO:0000269|PubMed:37036982, ECO:0000269|PubMed:37311461, ECO:0000269|PubMed:37595036, ECO:0000269|PubMed:37795761, ECO:0000269|PubMed:38377992, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}. |
| O95218 | ZRANB2 | S65 | ochoa | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| O95810 | CAVIN2 | S403 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P02545 | LMNA | S458 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05455 | SSB | S225 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P06213 | INSR | S1314 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P09429 | HMGB1 | S39 | ochoa|psp | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P11171 | EPB41 | S684 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12882 | MYH1 | S1331 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P13010 | XRCC5 | S318 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13521 | SCG2 | S106 | ochoa | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
| P13639 | EEF2 | S325 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P13667 | PDIA4 | S470 | ochoa | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P14314 | PRKCSH | S168 | ochoa | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| P14618 | PKM | S100 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P14625 | HSP90B1 | S172 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P16070 | CD44 | S706 | ochoa|psp | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P18583 | SON | S1585 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P20810 | CAST | S499 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P20929 | NEB | S367 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P27824 | CANX | S564 | ochoa|psp | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| P28715 | ERCC5 | S697 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P35523 | CLCN1 | S886 | ochoa | Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle) | Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (PubMed:12456816, PubMed:16027167, PubMed:22521272, PubMed:22641783, PubMed:26007199, PubMed:26502825, PubMed:26510092, PubMed:7951242, PubMed:8112288, PubMed:8130334, PubMed:9122265, PubMed:9565403, PubMed:9736777). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (PubMed:10051520, PubMed:10962018, PubMed:29809153, PubMed:31022181). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:9122265, PubMed:9565403). {ECO:0000269|PubMed:10051520, ECO:0000269|PubMed:10962018, ECO:0000269|PubMed:12456816, ECO:0000269|PubMed:16027167, ECO:0000269|PubMed:22521272, ECO:0000269|PubMed:22641783, ECO:0000269|PubMed:26007199, ECO:0000269|PubMed:26502825, ECO:0000269|PubMed:26510092, ECO:0000269|PubMed:29809153, ECO:0000269|PubMed:31022181, ECO:0000269|PubMed:7951242, ECO:0000269|PubMed:8112288, ECO:0000269|PubMed:8130334, ECO:0000269|PubMed:9122265, ECO:0000269|PubMed:9565403, ECO:0000269|PubMed:9736777}. |
| P35573 | AGL | S383 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P40818 | USP8 | S641 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P46821 | MAP1B | S1187 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S1899 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48436 | SOX9 | S64 | psp | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P48634 | PRRC2A | S1110 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49321 | NASP | S191 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49768 | PSEN1 | S337 | ochoa | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P51531 | SMARCA2 | S670 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51532 | SMARCA4 | S699 | ochoa|psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51587 | BRCA2 | S253 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52701 | MSH6 | S219 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| Q01484 | ANK2 | S2243 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02952 | AKAP12 | S353 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S392 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S472 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | S1114 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q04726 | TLE3 | S245 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q04727 | TLE4 | S250 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
| Q08AE8 | SPIRE1 | S257 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
| Q09666 | AHNAK | S4425 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S96 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13043 | STK4 | S320 | ochoa|psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13308 | PTK7 | S337 | ochoa | Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}. |
| Q13428 | TCOF1 | S1199 | ochoa|psp | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13547 | HDAC1 | S85 | ochoa | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 (PubMed:12837748, PubMed:16285960, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase and delactylase by mediating decrotonylation ((2E)-butenoyl) and delactylation (lactoyl) of histones, respectively (PubMed:28497810, PubMed:35044827). {ECO:0000250|UniProtKB:O09106, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:35044827}. |
| Q13796 | SHROOM2 | S1337 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14192 | FHL2 | S255 | ochoa | Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}. |
| Q15047 | SETDB1 | S878 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15643 | TRIP11 | S467 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q16513 | PKN2 | S163 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q1KMD3 | HNRNPUL2 | S168 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q3T8J9 | GON4L | S1337 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q53EZ4 | CEP55 | S285 | ochoa | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) | Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}. |
| Q5SW79 | CEP170 | S488 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T2D3 | OTUD3 | S224 | ochoa | OTU domain-containing protein 3 (EC 3.4.19.12) | Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:23827681, PubMed:32011234, PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32011234, ECO:0000269|PubMed:35675826}. |
| Q5UIP0 | RIF1 | S1576 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1851 | psp | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S1024 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT06 | CEP350 | S2341 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT97 | SYDE2 | S317 | ochoa | Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q5VUB5 | FAM171A1 | S443 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VZE5 | NAA35 | S187 | ochoa | N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog) | Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Involved in regulation of apoptosis and proliferation of smooth muscle cells (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q68D51 | DENND2C | S305 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6FIF0 | ZFAND6 | S123 | ochoa | AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}. |
| Q7Z417 | NUFIP2 | S266 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z739 | YTHDF3 | S425 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
| Q86UE4 | MTDH | S478 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86X53 | ERICH1 | S238 | ochoa | Glutamate-rich protein 1 | None |
| Q86X53 | ERICH1 | S254 | ochoa | Glutamate-rich protein 1 | None |
| Q86XK3 | SFR1 | S107 | ochoa | Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) | Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}. |
| Q8IXT5 | RBM12B | S591 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8IXT5 | RBM12B | S839 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8N129 | CNPY4 | S53 | ochoa | Protein canopy homolog 4 | Plays a role in the regulation of the cell surface expression of TLR4. {ECO:0000269|PubMed:16338228}. |
| Q8N302 | AGGF1 | S171 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N3Z6 | ZCCHC7 | S142 | ochoa | Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) | None |
| Q8N5C6 | SRBD1 | S152 | ochoa | S1 RNA-binding domain-containing protein 1 | None |
| Q8N6H7 | ARFGAP2 | S400 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NE00 | TMEM104 | S94 | ochoa | Transmembrane protein 104 | None |
| Q8TC76 | FAM110B | S301 | ochoa | Protein FAM110B | May be involved in tumor progression. |
| Q8TD10 | MIPOL1 | S42 | ochoa | Mirror-image polydactyly gene 1 protein | None |
| Q8WVC0 | LEO1 | S220 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WVC0 | LEO1 | S271 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q8WWM7 | ATXN2L | S589 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q92766 | RREB1 | S231 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92769 | HDAC2 | S86 | ochoa | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
| Q92793 | CREBBP | S1030 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q969G3 | SMARCE1 | S316 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96DT7 | ZBTB10 | S80 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96G28 | CFAP36 | S201 | ochoa | Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) | May act as an effector for ARL3. |
| Q96JB2 | COG3 | S511 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96K76 | USP47 | S1025 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96N46 | TTC14 | S734 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96Q42 | ALS2 | S466 | ochoa | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96QT4 | TRPM7 | S1468 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q99767 | APBA2 | S238 | psp | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Q9BUG6 | ZSCAN5A | S237 | ochoa | Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) | May be involved in transcriptional regulation. |
| Q9BV36 | MLPH | S420 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BVI0 | PHF20 | S225 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BXW9 | FANCD2 | S1412 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BY89 | KIAA1671 | S402 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYJ9 | YTHDF1 | S398 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
| Q9C0C2 | TNKS1BP1 | S1004 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZU2 | PEG3 | S671 | ochoa | Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24) | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}. |
| Q9H3R0 | KDM4C | S481 | ochoa | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Q9H4I2 | ZHX3 | S708 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H9L4 | KANSL2 | S168 | ochoa | KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac) (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). {ECO:0000250|UniProtKB:Q8BQR4, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:33657400}. |
| Q9NW13 | RBM28 | S644 | ochoa | RNA-binding protein 28 (RNA-binding motif protein 28) | Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
| Q9NYV4 | CDK12 | S1191 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZB2 | FAM120A | S1040 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P275 | USP36 | S825 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UBW5 | BIN2 | S90 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UGP8 | SEC63 | S593 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UJU2 | LEF1 | S61 | psp | Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha) | Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:P27782, ECO:0000269|PubMed:11266540, ECO:0000269|PubMed:19653274, ECO:0000269|PubMed:2010090}.; FUNCTION: [Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. {ECO:0000269|PubMed:19653274}.; FUNCTION: [Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. {ECO:0000269|PubMed:11326276}.; FUNCTION: [Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. {ECO:0000269|PubMed:19653274}. |
| Q9UKN8 | GTF3C4 | S652 | ochoa | General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) | Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658). {ECO:0000269|PubMed:10523658}. |
| Q9UL42 | PNMA2 | S340 | ochoa | Paraneoplastic antigen Ma2 (40 kDa neuronal protein) (Onconeuronal antigen Ma2) (Paraneoplastic neuronal antigen MM2) | None |
| Q9ULH0 | KIDINS220 | S1741 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULW3 | ABT1 | S188 | ochoa | Activator of basal transcription 1 (hABT1) (Basal transcriptional activator) | Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). {ECO:0000250}. |
| Q9Y3B9 | RRP15 | S51 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y3E1 | HDGFL3 | S180 | ochoa | Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) | Enhances DNA synthesis and may play a role in cell proliferation. {ECO:0000269|PubMed:10581169}. |
| Q9Y3T9 | NOC2L | S673 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y4B5 | MTCL1 | S794 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4W2 | LAS1L | S510 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| Q9Y5A9 | YTHDF2 | S419 | ochoa | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:24284625, PubMed:26046440, PubMed:26318451, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:24284625, PubMed:26046440, PubMed:27558897, PubMed:30930054, PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (PubMed:30930054). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:27558897). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (PubMed:32169943). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (PubMed:30428350). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (PubMed:32267835). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:31642031, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (PubMed:31815440). {ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658, ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:30065315, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:31642031, ECO:0000269|PubMed:31815440, ECO:0000269|PubMed:32169943, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: (Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282). {ECO:0000269|PubMed:29447282}.; FUNCTION: (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) (PubMed:29659627). Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29659627). {ECO:0000269|PubMed:29659627}. |
| Q9Y5B6 | PAXBP1 | S158 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y6X4 | FAM169A | S619 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
| Q9Y6Y8 | SEC23IP | S926 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| R4GMW8 | BIVM-ERCC5 | S1151 | ochoa | DNA excision repair protein ERCC-5 | None |
| P20810 | CAST | S337 | Sugiyama | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P25208 | NFYB | S99 | Sugiyama | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| P33240 | CSTF2 | S44 | Sugiyama | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P46060 | RANGAP1 | S50 | Sugiyama | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P09497 | CLTB | S144 | Sugiyama | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
| O00116 | AGPS | S176 | Sugiyama | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
| Q9P032 | NDUFAF4 | S35 | Sugiyama | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. {ECO:0000269|PubMed:14871833, ECO:0000269|PubMed:17001319, ECO:0000269|PubMed:18179882, ECO:0000269|PubMed:28853723}. |
| P20248 | CCNA2 | S130 | Sugiyama | Cyclin-A2 (Cyclin-A) (Cyclin A) | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}. |
| P00505 | GOT2 | S118 | Sugiyama | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
| P17844 | DDX5 | S422 | Sugiyama | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P14868 | DARS1 | S37 | Sugiyama | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}. |
| Q99962 | SH3GL2 | S64 | Sugiyama | Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}. |
| Q08881 | ITK | S204 | Sugiyama | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q02880 | TOP2B | S1135 | SIGNOR | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q15208 | STK38 | S398 | Sugiyama | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}. |
| Q9NQP4 | PFDN4 | S103 | Sugiyama | Prefoldin subunit 4 (Protein C-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| O15042 | U2SURP | S302 | Sugiyama | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| Q99627 | COPS8 | S157 | Sugiyama | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q9NR50 | EIF2B3 | S265 | Sugiyama | Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 4.664945e-07 | 6.331 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.036968e-06 | 5.984 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.242287e-05 | 4.906 |
| R-HSA-4641265 | Repression of WNT target genes | 3.663690e-05 | 4.436 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.115502e-04 | 3.953 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.625930e-04 | 3.789 |
| R-HSA-4839726 | Chromatin organization | 2.646005e-04 | 3.577 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.659492e-04 | 3.437 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.158605e-04 | 3.381 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.079102e-04 | 3.294 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.626087e-04 | 3.250 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 6.940733e-04 | 3.159 |
| R-HSA-1299308 | Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | 9.758355e-04 | 3.011 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.111877e-03 | 2.954 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.170143e-03 | 2.932 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.170143e-03 | 2.932 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 9.938856e-04 | 3.003 |
| R-HSA-195721 | Signaling by WNT | 1.041792e-03 | 2.982 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.387029e-03 | 2.858 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.409532e-03 | 2.851 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.578995e-03 | 2.802 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.889183e-03 | 2.724 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 2.163470e-03 | 2.665 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.132382e-03 | 2.671 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.960177e-03 | 2.529 |
| R-HSA-350054 | Notch-HLH transcription pathway | 4.058062e-03 | 2.392 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 5.373954e-03 | 2.270 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 5.373954e-03 | 2.270 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.615056e-03 | 2.118 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.615056e-03 | 2.118 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.615056e-03 | 2.118 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.615056e-03 | 2.118 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.615056e-03 | 2.118 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.615056e-03 | 2.118 |
| R-HSA-1538133 | G0 and Early G1 | 9.349991e-03 | 2.029 |
| R-HSA-9683686 | Maturation of spike protein | 9.647086e-03 | 2.016 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 9.647086e-03 | 2.016 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.002597e-02 | 1.999 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.265714e-02 | 1.898 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.210002e-02 | 1.917 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.237273e-02 | 1.908 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.210002e-02 | 1.917 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.429615e-02 | 1.845 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.602160e-02 | 1.795 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.670021e-02 | 1.777 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.737789e-02 | 1.760 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.223085e-02 | 1.653 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 2.223085e-02 | 1.653 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.223085e-02 | 1.653 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.972341e-02 | 1.705 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.932724e-02 | 1.714 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 2.169564e-02 | 1.664 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.139264e-02 | 1.670 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.972341e-02 | 1.705 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.220486e-02 | 1.654 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.220486e-02 | 1.654 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.231362e-02 | 1.651 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 2.374608e-02 | 1.624 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.374608e-02 | 1.624 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.587213e-02 | 1.587 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.807367e-02 | 1.552 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.807367e-02 | 1.552 |
| R-HSA-73894 | DNA Repair | 2.889036e-02 | 1.539 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 3.316127e-02 | 1.479 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.316127e-02 | 1.479 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.269079e-02 | 1.486 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.081543e-02 | 1.511 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.239280e-02 | 1.490 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.545162e-02 | 1.450 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.562180e-02 | 1.448 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.646131e-02 | 1.438 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.758260e-02 | 1.425 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.758260e-02 | 1.425 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 6.522874e-02 | 1.186 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 7.568106e-02 | 1.121 |
| R-HSA-74713 | IRS activation | 7.568106e-02 | 1.121 |
| R-HSA-68911 | G2 Phase | 7.568106e-02 | 1.121 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 7.568106e-02 | 1.121 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.063458e-01 | 0.973 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.063458e-01 | 0.973 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.063458e-01 | 0.973 |
| R-HSA-196025 | Formation of annular gap junctions | 1.163408e-01 | 0.934 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.262247e-01 | 0.899 |
| R-HSA-170984 | ARMS-mediated activation | 1.262247e-01 | 0.899 |
| R-HSA-190873 | Gap junction degradation | 1.262247e-01 | 0.899 |
| R-HSA-164843 | 2-LTR circle formation | 1.359986e-01 | 0.866 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.012700e-02 | 1.397 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.552214e-01 | 0.809 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.365935e-01 | 0.626 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.451392e-01 | 0.611 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.451392e-01 | 0.611 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.451392e-01 | 0.611 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.451392e-01 | 0.611 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.535897e-01 | 0.596 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.619462e-01 | 0.582 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.619462e-01 | 0.582 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.783810e-01 | 0.555 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.944518e-01 | 0.531 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.101667e-01 | 0.508 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.255334e-01 | 0.487 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.984577e-01 | 0.702 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.147993e-01 | 0.668 |
| R-HSA-1989781 | PPARA activates gene expression | 1.320075e-01 | 0.879 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 2.560859e-01 | 0.592 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.740189e-01 | 0.759 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.359701e-01 | 0.867 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 5.092085e-02 | 1.293 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.103749e-01 | 0.677 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.702096e-01 | 0.568 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.101667e-01 | 0.508 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.646727e-01 | 0.783 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.044651e-02 | 1.219 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.903459e-01 | 0.720 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.192124e-01 | 0.659 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.832610e-01 | 0.737 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.093376e-01 | 0.961 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.092955e-01 | 0.961 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.377810e-02 | 1.132 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.107010e-01 | 0.676 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.330886e-01 | 0.477 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.023532e-01 | 0.519 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.984461e-02 | 1.156 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.560859e-01 | 0.592 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.590213e-02 | 1.338 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.552214e-01 | 0.809 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.044651e-02 | 1.219 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 8.498387e-02 | 1.071 |
| R-HSA-74158 | RNA Polymerase III Transcription | 8.498387e-02 | 1.071 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 5.465887e-02 | 1.262 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 8.601715e-02 | 1.065 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 9.623830e-02 | 1.017 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.359986e-01 | 0.866 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.552214e-01 | 0.809 |
| R-HSA-75896 | Plasmalogen biosynthesis | 1.552214e-01 | 0.809 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 5.961691e-02 | 1.225 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.279516e-01 | 0.642 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 9.868501e-02 | 1.006 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.057533e-01 | 0.976 |
| R-HSA-77387 | Insulin receptor recycling | 3.178931e-01 | 0.498 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.205185e-01 | 0.919 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.271363e-01 | 0.644 |
| R-HSA-9843745 | Adipogenesis | 2.298213e-01 | 0.639 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.646727e-01 | 0.783 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.163408e-01 | 0.934 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.864341e-02 | 1.232 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.698841e-01 | 0.770 |
| R-HSA-5358508 | Mismatch Repair | 2.279516e-01 | 0.642 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 6.878049e-02 | 1.163 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.014379e-01 | 0.696 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.864614e-01 | 0.543 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.584352e-01 | 0.800 |
| R-HSA-6798695 | Neutrophil degranulation | 1.721466e-01 | 0.764 |
| R-HSA-5693538 | Homology Directed Repair | 1.865391e-01 | 0.729 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.822813e-01 | 0.739 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.646727e-01 | 0.783 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 8.498387e-02 | 1.071 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.497297e-02 | 1.347 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 9.868501e-02 | 1.006 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 9.868501e-02 | 1.006 |
| R-HSA-525793 | Myogenesis | 3.023532e-01 | 0.519 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.395227e-01 | 0.621 |
| R-HSA-9033241 | Peroxisomal protein import | 1.742702e-01 | 0.759 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 5.465887e-02 | 1.262 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 1.163408e-01 | 0.934 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.924003e-01 | 0.716 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.780831e-02 | 1.109 |
| R-HSA-169893 | Prolonged ERK activation events | 2.014379e-01 | 0.696 |
| R-HSA-1500620 | Meiosis | 2.809600e-01 | 0.551 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.166573e-01 | 0.933 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.768158e-01 | 0.558 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 9.623830e-02 | 1.017 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.646727e-01 | 0.783 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.169322e-02 | 1.287 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.103749e-01 | 0.677 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.406067e-01 | 0.852 |
| R-HSA-9675135 | Diseases of DNA repair | 1.239820e-01 | 0.907 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.271363e-01 | 0.644 |
| R-HSA-199991 | Membrane Trafficking | 7.604549e-02 | 1.119 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.262247e-01 | 0.899 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.359986e-01 | 0.866 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.740189e-01 | 0.759 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.924003e-01 | 0.716 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.014379e-01 | 0.696 |
| R-HSA-9694548 | Maturation of spike protein | 1.022020e-01 | 0.991 |
| R-HSA-429947 | Deadenylation of mRNA | 2.864614e-01 | 0.543 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.864614e-01 | 0.543 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.353894e-01 | 0.628 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.643776e-01 | 0.578 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 7.837141e-02 | 1.106 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.663192e-01 | 0.779 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.428422e-01 | 0.845 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.022020e-01 | 0.991 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.277143e-01 | 0.894 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 1.352569e-01 | 0.869 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.064709e-02 | 1.217 |
| R-HSA-162592 | Integration of provirus | 1.552214e-01 | 0.809 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 7.512935e-02 | 1.124 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.330886e-01 | 0.477 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.334576e-01 | 0.632 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.568106e-02 | 1.121 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.063458e-01 | 0.973 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.262247e-01 | 0.899 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.262247e-01 | 0.899 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.646727e-01 | 0.783 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.646727e-01 | 0.783 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.646727e-01 | 0.783 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.740189e-01 | 0.759 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.740189e-01 | 0.759 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.832610e-01 | 0.737 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.924003e-01 | 0.716 |
| R-HSA-2028269 | Signaling by Hippo | 2.192124e-01 | 0.659 |
| R-HSA-8848584 | Wax and plasmalogen biosynthesis | 2.451392e-01 | 0.611 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.023532e-01 | 0.519 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.782686e-01 | 0.749 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.178931e-01 | 0.498 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.382582e-01 | 0.623 |
| R-HSA-3928664 | Ephrin signaling | 2.279516e-01 | 0.642 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.365935e-01 | 0.626 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.864614e-01 | 0.543 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.808034e-01 | 0.552 |
| R-HSA-157118 | Signaling by NOTCH | 7.468304e-02 | 1.127 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.359986e-01 | 0.866 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.103749e-01 | 0.677 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 2.192124e-01 | 0.659 |
| R-HSA-2160916 | Hyaluronan degradation | 2.944518e-01 | 0.531 |
| R-HSA-74160 | Gene expression (Transcription) | 1.741801e-01 | 0.759 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 5.092085e-02 | 1.293 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.535897e-01 | 0.596 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.619462e-01 | 0.582 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.892426e-01 | 0.539 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.304232e-01 | 0.481 |
| R-HSA-9020956 | Interleukin-27 signaling | 1.359986e-01 | 0.866 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.277143e-01 | 0.894 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 7.512935e-02 | 1.124 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 8.601715e-02 | 1.065 |
| R-HSA-74749 | Signal attenuation | 1.359986e-01 | 0.866 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.832610e-01 | 0.737 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.832610e-01 | 0.737 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.023532e-01 | 0.519 |
| R-HSA-3295583 | TRP channels | 3.023532e-01 | 0.519 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.178931e-01 | 0.498 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.540406e-02 | 1.343 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.540406e-02 | 1.343 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.330886e-01 | 0.477 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 9.523421e-02 | 1.021 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.584352e-01 | 0.800 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.535897e-01 | 0.596 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.702096e-01 | 0.568 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.783810e-01 | 0.555 |
| R-HSA-3214847 | HATs acetylate histones | 1.279211e-01 | 0.893 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.993437e-02 | 1.155 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 5.376502e-02 | 1.270 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.740189e-01 | 0.759 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.780831e-02 | 1.109 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.944518e-01 | 0.531 |
| R-HSA-8953854 | Metabolism of RNA | 1.682752e-01 | 0.774 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.535897e-01 | 0.596 |
| R-HSA-3214842 | HDMs demethylate histones | 2.944518e-01 | 0.531 |
| R-HSA-1266738 | Developmental Biology | 2.877125e-01 | 0.541 |
| R-HSA-8876725 | Protein methylation | 1.924003e-01 | 0.716 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.535897e-01 | 0.596 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.863073e-01 | 0.730 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.330886e-01 | 0.477 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.809600e-01 | 0.551 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.883952e-01 | 0.540 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.353894e-01 | 0.628 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.851024e-01 | 0.545 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.171706e-02 | 1.286 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.352569e-01 | 0.869 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.352569e-01 | 0.869 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 8.829366e-02 | 1.054 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.098937e-01 | 0.509 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 8.835159e-02 | 1.054 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.451392e-01 | 0.611 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.619462e-01 | 0.582 |
| R-HSA-9683701 | Translation of Structural Proteins | 1.057533e-01 | 0.976 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.975143e-01 | 0.526 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.101667e-01 | 0.508 |
| R-HSA-8939211 | ESR-mediated signaling | 3.276474e-01 | 0.485 |
| R-HSA-8984722 | Interleukin-35 Signalling | 1.646727e-01 | 0.783 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.535897e-01 | 0.596 |
| R-HSA-597592 | Post-translational protein modification | 8.964542e-02 | 1.047 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 7.193191e-02 | 1.143 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 7.193191e-02 | 1.143 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.702096e-01 | 0.568 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.615019e-02 | 1.251 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.085538e-01 | 0.964 |
| R-HSA-6807070 | PTEN Regulation | 2.566291e-01 | 0.591 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 8.498387e-02 | 1.071 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.477994e-01 | 0.606 |
| R-HSA-70268 | Pyruvate metabolism | 2.933800e-01 | 0.533 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.571153e-01 | 0.590 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.903459e-01 | 0.720 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.279211e-01 | 0.893 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.189051e-01 | 0.660 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 7.568106e-02 | 1.121 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2.014379e-01 | 0.696 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.057533e-01 | 0.976 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.623684e-01 | 0.789 |
| R-HSA-6806834 | Signaling by MET | 2.602314e-01 | 0.585 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 9.520343e-02 | 1.021 |
| R-HSA-418990 | Adherens junctions interactions | 5.339568e-02 | 1.272 |
| R-HSA-421270 | Cell-cell junction organization | 8.690808e-02 | 1.061 |
| R-HSA-216083 | Integrin cell surface interactions | 2.519417e-01 | 0.599 |
| R-HSA-1500931 | Cell-Cell communication | 8.655893e-02 | 1.063 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.851425e-01 | 0.545 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.365935e-01 | 0.626 |
| R-HSA-75153 | Apoptotic execution phase | 1.239820e-01 | 0.907 |
| R-HSA-1296071 | Potassium Channels | 3.385900e-01 | 0.470 |
| R-HSA-446728 | Cell junction organization | 1.212510e-01 | 0.916 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.740189e-01 | 0.759 |
| R-HSA-168268 | Virus Assembly and Release | 2.014379e-01 | 0.696 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.663192e-01 | 0.779 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.192124e-01 | 0.659 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.181229e-01 | 0.497 |
| R-HSA-5620971 | Pyroptosis | 3.178931e-01 | 0.498 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.832610e-01 | 0.737 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.944518e-01 | 0.531 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.691299e-02 | 1.061 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.365935e-01 | 0.626 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.235236e-01 | 0.490 |
| R-HSA-73887 | Death Receptor Signaling | 3.051781e-01 | 0.515 |
| R-HSA-201556 | Signaling by ALK | 9.520343e-02 | 1.021 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.892426e-01 | 0.539 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.140109e-01 | 0.503 |
| R-HSA-182971 | EGFR downregulation | 3.405597e-01 | 0.468 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.405597e-01 | 0.468 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.405597e-01 | 0.468 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 3.405597e-01 | 0.468 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.426623e-01 | 0.465 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.426623e-01 | 0.465 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.479475e-01 | 0.458 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.479475e-01 | 0.458 |
| R-HSA-70171 | Glycolysis | 3.548307e-01 | 0.450 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.552530e-01 | 0.449 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.552530e-01 | 0.449 |
| R-HSA-9930044 | Nuclear RNA decay | 3.552530e-01 | 0.449 |
| R-HSA-9733709 | Cardiogenesis | 3.552530e-01 | 0.449 |
| R-HSA-390522 | Striated Muscle Contraction | 3.624770e-01 | 0.441 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.624770e-01 | 0.441 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.624770e-01 | 0.441 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.624770e-01 | 0.441 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 3.624770e-01 | 0.441 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.632410e-01 | 0.440 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.662858e-01 | 0.436 |
| R-HSA-9675108 | Nervous system development | 3.675638e-01 | 0.435 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.696206e-01 | 0.432 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.696206e-01 | 0.432 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.696206e-01 | 0.432 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.696206e-01 | 0.432 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.696206e-01 | 0.432 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.696206e-01 | 0.432 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.696206e-01 | 0.432 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.696206e-01 | 0.432 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.696206e-01 | 0.432 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.696206e-01 | 0.432 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.723682e-01 | 0.429 |
| R-HSA-5688426 | Deubiquitination | 3.733262e-01 | 0.428 |
| R-HSA-9833110 | RSV-host interactions | 3.749308e-01 | 0.426 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.766846e-01 | 0.424 |
| R-HSA-187687 | Signalling to ERKs | 3.766846e-01 | 0.424 |
| R-HSA-381042 | PERK regulates gene expression | 3.766846e-01 | 0.424 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.789211e-01 | 0.421 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.803595e-01 | 0.420 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.809341e-01 | 0.419 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.836699e-01 | 0.416 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.836699e-01 | 0.416 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.905773e-01 | 0.408 |
| R-HSA-419037 | NCAM1 interactions | 3.905773e-01 | 0.408 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.905773e-01 | 0.408 |
| R-HSA-8948216 | Collagen chain trimerization | 3.905773e-01 | 0.408 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.908275e-01 | 0.408 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.908275e-01 | 0.408 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.935928e-01 | 0.405 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.974077e-01 | 0.401 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.974077e-01 | 0.401 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.041620e-01 | 0.393 |
| R-HSA-69541 | Stabilization of p53 | 4.041620e-01 | 0.393 |
| R-HSA-212436 | Generic Transcription Pathway | 4.062467e-01 | 0.391 |
| R-HSA-5260271 | Diseases of Immune System | 4.108410e-01 | 0.386 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.108410e-01 | 0.386 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.108410e-01 | 0.386 |
| R-HSA-3371568 | Attenuation phase | 4.108410e-01 | 0.386 |
| R-HSA-202433 | Generation of second messenger molecules | 4.108410e-01 | 0.386 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.108410e-01 | 0.386 |
| R-HSA-8982491 | Glycogen metabolism | 4.108410e-01 | 0.386 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.108410e-01 | 0.386 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.174455e-01 | 0.379 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.174455e-01 | 0.379 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.174455e-01 | 0.379 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 4.239764e-01 | 0.373 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.294472e-01 | 0.367 |
| R-HSA-373760 | L1CAM interactions | 4.297451e-01 | 0.367 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.304345e-01 | 0.366 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.335661e-01 | 0.363 |
| R-HSA-70326 | Glucose metabolism | 4.335661e-01 | 0.363 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.337944e-01 | 0.363 |
| R-HSA-1640170 | Cell Cycle | 4.351292e-01 | 0.361 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.431354e-01 | 0.353 |
| R-HSA-190828 | Gap junction trafficking | 4.431354e-01 | 0.353 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.431354e-01 | 0.353 |
| R-HSA-68875 | Mitotic Prophase | 4.449467e-01 | 0.352 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.471131e-01 | 0.350 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.493798e-01 | 0.347 |
| R-HSA-9824272 | Somitogenesis | 4.493798e-01 | 0.347 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 4.493798e-01 | 0.347 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.555546e-01 | 0.341 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.555546e-01 | 0.341 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.555546e-01 | 0.341 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.562001e-01 | 0.341 |
| R-HSA-437239 | Recycling pathway of L1 | 4.616605e-01 | 0.336 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.616605e-01 | 0.336 |
| R-HSA-72172 | mRNA Splicing | 4.616689e-01 | 0.336 |
| R-HSA-69206 | G1/S Transition | 4.673223e-01 | 0.330 |
| R-HSA-5620924 | Intraflagellar transport | 4.676984e-01 | 0.330 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.676984e-01 | 0.330 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.732563e-01 | 0.325 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.736688e-01 | 0.325 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 4.736688e-01 | 0.325 |
| R-HSA-69481 | G2/M Checkpoints | 4.746623e-01 | 0.324 |
| R-HSA-392499 | Metabolism of proteins | 4.749140e-01 | 0.323 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.769606e-01 | 0.322 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.783095e-01 | 0.320 |
| R-HSA-397014 | Muscle contraction | 4.846098e-01 | 0.315 |
| R-HSA-912446 | Meiotic recombination | 4.854107e-01 | 0.314 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.854107e-01 | 0.314 |
| R-HSA-1474165 | Reproduction | 4.891584e-01 | 0.311 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.911836e-01 | 0.309 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.911836e-01 | 0.309 |
| R-HSA-72187 | mRNA 3'-end processing | 4.911836e-01 | 0.309 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.911836e-01 | 0.309 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.911836e-01 | 0.309 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.911836e-01 | 0.309 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.911836e-01 | 0.309 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.911836e-01 | 0.309 |
| R-HSA-5576891 | Cardiac conduction | 4.927434e-01 | 0.307 |
| R-HSA-68882 | Mitotic Anaphase | 4.959064e-01 | 0.305 |
| R-HSA-9909396 | Circadian clock | 4.963127e-01 | 0.304 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.968921e-01 | 0.304 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.968921e-01 | 0.304 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.968921e-01 | 0.304 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.968921e-01 | 0.304 |
| R-HSA-1221632 | Meiotic synapsis | 4.968921e-01 | 0.304 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.968921e-01 | 0.304 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.987115e-01 | 0.302 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.025369e-01 | 0.299 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.081187e-01 | 0.294 |
| R-HSA-8951664 | Neddylation | 5.098532e-01 | 0.293 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.136382e-01 | 0.289 |
| R-HSA-177929 | Signaling by EGFR | 5.136382e-01 | 0.289 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.139188e-01 | 0.289 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.173914e-01 | 0.286 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.244931e-01 | 0.280 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.244931e-01 | 0.280 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.298298e-01 | 0.276 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.298298e-01 | 0.276 |
| R-HSA-180786 | Extension of Telomeres | 5.298298e-01 | 0.276 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.298298e-01 | 0.276 |
| R-HSA-186712 | Regulation of beta-cell development | 5.298298e-01 | 0.276 |
| R-HSA-379724 | tRNA Aminoacylation | 5.351070e-01 | 0.272 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.351070e-01 | 0.272 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.403253e-01 | 0.267 |
| R-HSA-1442490 | Collagen degradation | 5.403253e-01 | 0.267 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.454853e-01 | 0.263 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.454853e-01 | 0.263 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.454853e-01 | 0.263 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.454853e-01 | 0.263 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.454853e-01 | 0.263 |
| R-HSA-9707616 | Heme signaling | 5.454853e-01 | 0.263 |
| R-HSA-186797 | Signaling by PDGF | 5.454853e-01 | 0.263 |
| R-HSA-6799198 | Complex I biogenesis | 5.505877e-01 | 0.259 |
| R-HSA-373755 | Semaphorin interactions | 5.505877e-01 | 0.259 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.556332e-01 | 0.255 |
| R-HSA-166520 | Signaling by NTRKs | 5.577673e-01 | 0.254 |
| R-HSA-1474244 | Extracellular matrix organization | 5.578331e-01 | 0.253 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.606223e-01 | 0.251 |
| R-HSA-9758941 | Gastrulation | 5.610225e-01 | 0.251 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.642606e-01 | 0.249 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.704340e-01 | 0.244 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.704340e-01 | 0.244 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.706857e-01 | 0.244 |
| R-HSA-9609507 | Protein localization | 5.738726e-01 | 0.241 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.752578e-01 | 0.240 |
| R-HSA-5218859 | Regulated Necrosis | 5.752578e-01 | 0.240 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 5.800294e-01 | 0.237 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.822142e-01 | 0.235 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.847445e-01 | 0.233 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.847445e-01 | 0.233 |
| R-HSA-162587 | HIV Life Cycle | 5.864488e-01 | 0.232 |
| R-HSA-3000178 | ECM proteoglycans | 5.894085e-01 | 0.230 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.894085e-01 | 0.230 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.894085e-01 | 0.230 |
| R-HSA-877300 | Interferon gamma signaling | 5.926339e-01 | 0.227 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.940204e-01 | 0.226 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.973261e-01 | 0.224 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.985808e-01 | 0.223 |
| R-HSA-4086398 | Ca2+ pathway | 5.985808e-01 | 0.223 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.985808e-01 | 0.223 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.013917e-01 | 0.221 |
| R-HSA-109581 | Apoptosis | 6.017826e-01 | 0.221 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.030902e-01 | 0.220 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.030902e-01 | 0.220 |
| R-HSA-8852135 | Protein ubiquitination | 6.075493e-01 | 0.216 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.075493e-01 | 0.216 |
| R-HSA-422475 | Axon guidance | 6.142322e-01 | 0.212 |
| R-HSA-4086400 | PCP/CE pathway | 6.206298e-01 | 0.207 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.265620e-01 | 0.203 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.283012e-01 | 0.202 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.291083e-01 | 0.201 |
| R-HSA-9679506 | SARS-CoV Infections | 6.311504e-01 | 0.200 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.332766e-01 | 0.198 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.373983e-01 | 0.196 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.414739e-01 | 0.193 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.424348e-01 | 0.192 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.455040e-01 | 0.190 |
| R-HSA-112316 | Neuronal System | 6.455290e-01 | 0.190 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.492604e-01 | 0.188 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.494891e-01 | 0.187 |
| R-HSA-611105 | Respiratory electron transport | 6.507112e-01 | 0.187 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.534296e-01 | 0.185 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.534296e-01 | 0.185 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.573260e-01 | 0.182 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.573260e-01 | 0.182 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.573260e-01 | 0.182 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.611788e-01 | 0.180 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.611788e-01 | 0.180 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.617546e-01 | 0.179 |
| R-HSA-156902 | Peptide chain elongation | 6.649886e-01 | 0.177 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.687558e-01 | 0.175 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.761642e-01 | 0.170 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.772067e-01 | 0.169 |
| R-HSA-983712 | Ion channel transport | 6.797649e-01 | 0.168 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.834078e-01 | 0.165 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.834078e-01 | 0.165 |
| R-HSA-391251 | Protein folding | 6.834078e-01 | 0.165 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.848318e-01 | 0.164 |
| R-HSA-1474290 | Collagen formation | 6.904903e-01 | 0.161 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.008197e-01 | 0.154 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.008197e-01 | 0.154 |
| R-HSA-157579 | Telomere Maintenance | 7.041860e-01 | 0.152 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.075147e-01 | 0.150 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.075147e-01 | 0.150 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.075147e-01 | 0.150 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.140607e-01 | 0.146 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.172789e-01 | 0.144 |
| R-HSA-1483255 | PI Metabolism | 7.204610e-01 | 0.142 |
| R-HSA-5357801 | Programmed Cell Death | 7.207755e-01 | 0.142 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.267188e-01 | 0.139 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.297953e-01 | 0.137 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.297953e-01 | 0.137 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.328373e-01 | 0.135 |
| R-HSA-69239 | Synthesis of DNA | 7.388195e-01 | 0.131 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.388195e-01 | 0.131 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.388195e-01 | 0.131 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.417605e-01 | 0.130 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.417605e-01 | 0.130 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.446685e-01 | 0.128 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.446685e-01 | 0.128 |
| R-HSA-202403 | TCR signaling | 7.475440e-01 | 0.126 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.475440e-01 | 0.126 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.475440e-01 | 0.126 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.531987e-01 | 0.123 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.559786e-01 | 0.121 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.559786e-01 | 0.121 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.587274e-01 | 0.120 |
| R-HSA-162582 | Signal Transduction | 7.598175e-01 | 0.119 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.641329e-01 | 0.117 |
| R-HSA-1280218 | Adaptive Immune System | 7.659938e-01 | 0.116 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.667903e-01 | 0.115 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.667903e-01 | 0.115 |
| R-HSA-162906 | HIV Infection | 7.672270e-01 | 0.115 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.694180e-01 | 0.114 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.694180e-01 | 0.114 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.720162e-01 | 0.112 |
| R-HSA-72312 | rRNA processing | 7.768052e-01 | 0.110 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.771255e-01 | 0.110 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.771255e-01 | 0.110 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.771255e-01 | 0.110 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.821210e-01 | 0.107 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.821210e-01 | 0.107 |
| R-HSA-73886 | Chromosome Maintenance | 7.821210e-01 | 0.107 |
| R-HSA-3371556 | Cellular response to heat stress | 7.821210e-01 | 0.107 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.845769e-01 | 0.105 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.845769e-01 | 0.105 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.850149e-01 | 0.105 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.870052e-01 | 0.104 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.894062e-01 | 0.103 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.941279e-01 | 0.100 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.941279e-01 | 0.100 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.941279e-01 | 0.100 |
| R-HSA-194138 | Signaling by VEGF | 7.941279e-01 | 0.100 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.054766e-01 | 0.094 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.119849e-01 | 0.090 |
| R-HSA-68886 | M Phase | 8.332740e-01 | 0.079 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.359226e-01 | 0.078 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.359226e-01 | 0.078 |
| R-HSA-168249 | Innate Immune System | 8.379874e-01 | 0.077 |
| R-HSA-69242 | S Phase | 8.467290e-01 | 0.072 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.467290e-01 | 0.072 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.501714e-01 | 0.070 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.518637e-01 | 0.070 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.535369e-01 | 0.069 |
| R-HSA-69306 | DNA Replication | 8.551914e-01 | 0.068 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.722084e-01 | 0.059 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.722084e-01 | 0.059 |
| R-HSA-72306 | tRNA processing | 8.819860e-01 | 0.055 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.833207e-01 | 0.054 |
| R-HSA-72766 | Translation | 8.836501e-01 | 0.054 |
| R-HSA-168255 | Influenza Infection | 8.934716e-01 | 0.049 |
| R-HSA-2559583 | Cellular Senescence | 8.946771e-01 | 0.048 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.969461e-01 | 0.047 |
| R-HSA-8957322 | Metabolism of steroids | 9.006310e-01 | 0.045 |
| R-HSA-69275 | G2/M Transition | 9.016302e-01 | 0.045 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.038450e-01 | 0.044 |
| R-HSA-9824446 | Viral Infection Pathways | 9.041848e-01 | 0.044 |
| R-HSA-5617833 | Cilium Assembly | 9.060101e-01 | 0.043 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.081267e-01 | 0.042 |
| R-HSA-68877 | Mitotic Prometaphase | 9.091672e-01 | 0.041 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.091672e-01 | 0.041 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.189486e-01 | 0.037 |
| R-HSA-449147 | Signaling by Interleukins | 9.347105e-01 | 0.029 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.397494e-01 | 0.027 |
| R-HSA-913531 | Interferon Signaling | 9.430683e-01 | 0.025 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.456340e-01 | 0.024 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.467147e-01 | 0.024 |
| R-HSA-2262752 | Cellular responses to stress | 9.507649e-01 | 0.022 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.547936e-01 | 0.020 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.618587e-01 | 0.017 |
| R-HSA-1483257 | Phospholipid metabolism | 9.720051e-01 | 0.012 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.845920e-01 | 0.007 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.858155e-01 | 0.006 |
| R-HSA-168256 | Immune System | 9.871912e-01 | 0.006 |
| R-HSA-5663205 | Infectious disease | 9.877995e-01 | 0.005 |
| R-HSA-1643685 | Disease | 9.908432e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.944348e-01 | 0.002 |
| R-HSA-109582 | Hemostasis | 9.948232e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.995521e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.998841e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.855 | 0.453 | 2 | 0.820 |
CDC7 |
0.852 | 0.406 | 1 | 0.854 |
CLK3 |
0.847 | 0.226 | 1 | 0.696 |
COT |
0.847 | 0.107 | 2 | 0.793 |
MOS |
0.844 | 0.342 | 1 | 0.822 |
GRK1 |
0.835 | 0.229 | -2 | 0.784 |
BMPR1B |
0.835 | 0.312 | 1 | 0.776 |
PIM3 |
0.834 | 0.110 | -3 | 0.840 |
DSTYK |
0.832 | 0.058 | 2 | 0.810 |
PRPK |
0.831 | -0.019 | -1 | 0.865 |
CAMK2G |
0.830 | 0.060 | 2 | 0.786 |
NDR2 |
0.830 | 0.053 | -3 | 0.845 |
IKKB |
0.829 | -0.024 | -2 | 0.760 |
IKKA |
0.828 | 0.095 | -2 | 0.760 |
MARK4 |
0.828 | 0.147 | 4 | 0.885 |
RAF1 |
0.828 | -0.029 | 1 | 0.692 |
CAMK1B |
0.826 | 0.033 | -3 | 0.856 |
GRK6 |
0.826 | 0.155 | 1 | 0.728 |
CAMK2B |
0.825 | 0.178 | 2 | 0.801 |
BMPR2 |
0.825 | 0.005 | -2 | 0.891 |
TBK1 |
0.824 | -0.089 | 1 | 0.566 |
NUAK2 |
0.824 | 0.054 | -3 | 0.850 |
ATR |
0.824 | -0.001 | 1 | 0.688 |
ATM |
0.824 | 0.080 | 1 | 0.673 |
SKMLCK |
0.824 | 0.066 | -2 | 0.835 |
GCN2 |
0.823 | -0.158 | 2 | 0.682 |
PDHK4 |
0.823 | -0.149 | 1 | 0.687 |
BMPR1A |
0.822 | 0.323 | 1 | 0.796 |
IKKE |
0.822 | -0.094 | 1 | 0.563 |
NEK6 |
0.822 | -0.016 | -2 | 0.897 |
CDKL1 |
0.822 | 0.028 | -3 | 0.801 |
SRPK1 |
0.822 | 0.072 | -3 | 0.759 |
PRKD1 |
0.822 | 0.037 | -3 | 0.828 |
ALK2 |
0.821 | 0.290 | -2 | 0.839 |
HIPK4 |
0.821 | 0.039 | 1 | 0.628 |
MTOR |
0.821 | -0.138 | 1 | 0.617 |
KIS |
0.821 | 0.018 | 1 | 0.539 |
PIM1 |
0.821 | 0.095 | -3 | 0.790 |
PKN3 |
0.821 | 0.002 | -3 | 0.829 |
HUNK |
0.820 | -0.023 | 2 | 0.705 |
AMPKA1 |
0.820 | 0.081 | -3 | 0.854 |
GRK5 |
0.820 | 0.029 | -3 | 0.830 |
TGFBR1 |
0.819 | 0.132 | -2 | 0.828 |
ERK5 |
0.819 | -0.049 | 1 | 0.617 |
NLK |
0.819 | -0.074 | 1 | 0.644 |
TGFBR2 |
0.818 | -0.036 | -2 | 0.837 |
LATS1 |
0.818 | 0.188 | -3 | 0.866 |
GRK4 |
0.818 | 0.027 | -2 | 0.838 |
RSK2 |
0.818 | 0.043 | -3 | 0.785 |
CAMK2D |
0.818 | 0.040 | -3 | 0.829 |
ULK2 |
0.818 | -0.161 | 2 | 0.668 |
NEK7 |
0.818 | -0.104 | -3 | 0.814 |
ACVR2B |
0.817 | 0.207 | -2 | 0.841 |
TSSK2 |
0.817 | 0.092 | -5 | 0.755 |
GRK7 |
0.817 | 0.138 | 1 | 0.649 |
MAPKAPK2 |
0.817 | 0.083 | -3 | 0.742 |
LATS2 |
0.816 | 0.035 | -5 | 0.691 |
CAMK2A |
0.816 | 0.110 | 2 | 0.781 |
TSSK1 |
0.815 | 0.081 | -3 | 0.878 |
PDHK1 |
0.815 | -0.185 | 1 | 0.671 |
NIK |
0.815 | -0.063 | -3 | 0.867 |
AMPKA2 |
0.815 | 0.072 | -3 | 0.826 |
ACVR2A |
0.814 | 0.147 | -2 | 0.826 |
CAMLCK |
0.814 | -0.024 | -2 | 0.823 |
SRPK2 |
0.814 | 0.068 | -3 | 0.684 |
QSK |
0.814 | 0.111 | 4 | 0.873 |
RIPK3 |
0.814 | -0.113 | 3 | 0.716 |
WNK1 |
0.814 | -0.071 | -2 | 0.850 |
DAPK2 |
0.813 | 0.001 | -3 | 0.860 |
PRKD2 |
0.813 | 0.027 | -3 | 0.786 |
NUAK1 |
0.813 | 0.049 | -3 | 0.797 |
P90RSK |
0.813 | 0.007 | -3 | 0.786 |
MLK1 |
0.813 | -0.118 | 2 | 0.699 |
NDR1 |
0.812 | -0.045 | -3 | 0.837 |
CDKL5 |
0.812 | 0.000 | -3 | 0.794 |
BCKDK |
0.812 | -0.086 | -1 | 0.805 |
PKCD |
0.812 | -0.003 | 2 | 0.684 |
MARK2 |
0.812 | 0.150 | 4 | 0.817 |
CHAK2 |
0.812 | -0.042 | -1 | 0.867 |
MARK3 |
0.812 | 0.147 | 4 | 0.852 |
CDK8 |
0.810 | -0.020 | 1 | 0.510 |
ALK4 |
0.810 | 0.040 | -2 | 0.848 |
MAPKAPK3 |
0.810 | -0.008 | -3 | 0.781 |
CK2A2 |
0.810 | 0.207 | 1 | 0.710 |
RSK3 |
0.810 | -0.006 | -3 | 0.777 |
ULK1 |
0.809 | -0.151 | -3 | 0.794 |
PLK3 |
0.809 | 0.046 | 2 | 0.720 |
SIK |
0.809 | 0.082 | -3 | 0.764 |
DYRK2 |
0.809 | 0.015 | 1 | 0.548 |
MST4 |
0.809 | -0.078 | 2 | 0.741 |
ICK |
0.809 | -0.008 | -3 | 0.837 |
CLK2 |
0.808 | 0.123 | -3 | 0.766 |
DNAPK |
0.808 | 0.044 | 1 | 0.585 |
SRPK3 |
0.808 | 0.041 | -3 | 0.724 |
PLK1 |
0.808 | -0.009 | -2 | 0.869 |
NIM1 |
0.807 | -0.051 | 3 | 0.778 |
P70S6KB |
0.807 | -0.011 | -3 | 0.799 |
ANKRD3 |
0.806 | -0.139 | 1 | 0.668 |
PKN2 |
0.805 | -0.088 | -3 | 0.832 |
NEK9 |
0.805 | -0.184 | 2 | 0.711 |
DLK |
0.805 | -0.146 | 1 | 0.657 |
RSK4 |
0.805 | 0.057 | -3 | 0.759 |
BRSK1 |
0.805 | 0.051 | -3 | 0.795 |
WNK3 |
0.805 | -0.229 | 1 | 0.636 |
CHK1 |
0.805 | 0.054 | -3 | 0.835 |
MARK1 |
0.804 | 0.117 | 4 | 0.855 |
CDK1 |
0.804 | 0.009 | 1 | 0.487 |
MLK3 |
0.804 | -0.054 | 2 | 0.633 |
CDK19 |
0.804 | -0.025 | 1 | 0.476 |
PKR |
0.803 | -0.044 | 1 | 0.666 |
TTBK2 |
0.803 | -0.143 | 2 | 0.597 |
MSK2 |
0.803 | -0.013 | -3 | 0.742 |
JNK3 |
0.803 | 0.012 | 1 | 0.510 |
JNK2 |
0.802 | 0.017 | 1 | 0.473 |
MASTL |
0.802 | -0.279 | -2 | 0.814 |
CDK5 |
0.802 | 0.002 | 1 | 0.538 |
PKACG |
0.801 | -0.045 | -2 | 0.695 |
CLK4 |
0.801 | 0.024 | -3 | 0.778 |
IRE2 |
0.801 | -0.087 | 2 | 0.628 |
QIK |
0.800 | -0.042 | -3 | 0.823 |
IRE1 |
0.800 | -0.144 | 1 | 0.613 |
MELK |
0.799 | -0.038 | -3 | 0.807 |
CAMK4 |
0.799 | -0.097 | -3 | 0.818 |
CLK1 |
0.799 | 0.030 | -3 | 0.758 |
TLK2 |
0.799 | -0.054 | 1 | 0.633 |
AURC |
0.799 | -0.010 | -2 | 0.602 |
MLK2 |
0.799 | -0.188 | 2 | 0.687 |
BRAF |
0.799 | 0.043 | -4 | 0.843 |
RIPK1 |
0.798 | -0.220 | 1 | 0.631 |
MEK1 |
0.798 | -0.142 | 2 | 0.716 |
MSK1 |
0.798 | 0.014 | -3 | 0.750 |
MLK4 |
0.798 | -0.084 | 2 | 0.610 |
CDK7 |
0.798 | -0.054 | 1 | 0.528 |
P38B |
0.797 | 0.004 | 1 | 0.478 |
PRKX |
0.797 | 0.071 | -3 | 0.705 |
CDK18 |
0.797 | -0.012 | 1 | 0.457 |
DYRK4 |
0.797 | 0.027 | 1 | 0.489 |
YSK4 |
0.797 | -0.143 | 1 | 0.600 |
HIPK2 |
0.797 | 0.023 | 1 | 0.475 |
CDK13 |
0.797 | -0.046 | 1 | 0.502 |
MYLK4 |
0.796 | -0.020 | -2 | 0.734 |
P38A |
0.796 | -0.026 | 1 | 0.529 |
PRKD3 |
0.796 | -0.025 | -3 | 0.754 |
BRSK2 |
0.796 | -0.033 | -3 | 0.812 |
PKACB |
0.795 | 0.021 | -2 | 0.625 |
CK2A1 |
0.795 | 0.152 | 1 | 0.678 |
PRP4 |
0.795 | 0.032 | -3 | 0.757 |
PASK |
0.795 | 0.067 | -3 | 0.852 |
PAK1 |
0.795 | -0.072 | -2 | 0.735 |
GRK2 |
0.795 | -0.046 | -2 | 0.714 |
PKCB |
0.795 | -0.056 | 2 | 0.624 |
P38G |
0.794 | -0.009 | 1 | 0.408 |
HIPK1 |
0.794 | 0.007 | 1 | 0.554 |
CDK17 |
0.794 | -0.021 | 1 | 0.415 |
P38D |
0.793 | 0.018 | 1 | 0.444 |
VRK2 |
0.793 | -0.276 | 1 | 0.695 |
SSTK |
0.793 | 0.069 | 4 | 0.846 |
ERK1 |
0.793 | -0.030 | 1 | 0.467 |
SMG1 |
0.793 | -0.093 | 1 | 0.645 |
CDK3 |
0.793 | 0.016 | 1 | 0.436 |
PLK2 |
0.793 | 0.082 | -3 | 0.780 |
PKCA |
0.792 | -0.075 | 2 | 0.620 |
CAMK1G |
0.791 | -0.028 | -3 | 0.763 |
MNK2 |
0.791 | -0.072 | -2 | 0.754 |
PKCG |
0.791 | -0.099 | 2 | 0.628 |
PAK3 |
0.791 | -0.129 | -2 | 0.737 |
PHKG1 |
0.790 | -0.125 | -3 | 0.824 |
MNK1 |
0.790 | -0.039 | -2 | 0.764 |
DYRK1A |
0.790 | -0.008 | 1 | 0.573 |
PIM2 |
0.790 | 0.005 | -3 | 0.754 |
PERK |
0.790 | -0.131 | -2 | 0.869 |
PKCZ |
0.789 | -0.099 | 2 | 0.653 |
AURA |
0.789 | -0.027 | -2 | 0.574 |
NEK2 |
0.789 | -0.179 | 2 | 0.671 |
AURB |
0.788 | -0.044 | -2 | 0.600 |
PLK4 |
0.788 | -0.125 | 2 | 0.511 |
ERK2 |
0.788 | -0.061 | 1 | 0.500 |
PKCH |
0.788 | -0.103 | 2 | 0.607 |
AKT2 |
0.788 | -0.006 | -3 | 0.705 |
DCAMKL1 |
0.788 | -0.030 | -3 | 0.803 |
CDK2 |
0.788 | -0.060 | 1 | 0.544 |
MEKK1 |
0.788 | -0.172 | 1 | 0.623 |
DYRK1B |
0.787 | -0.006 | 1 | 0.496 |
CDK12 |
0.787 | -0.055 | 1 | 0.476 |
TLK1 |
0.787 | -0.106 | -2 | 0.862 |
MAPKAPK5 |
0.787 | -0.093 | -3 | 0.716 |
DRAK1 |
0.787 | -0.128 | 1 | 0.611 |
CHAK1 |
0.787 | -0.181 | 2 | 0.618 |
HRI |
0.787 | -0.192 | -2 | 0.873 |
CDK16 |
0.787 | -0.001 | 1 | 0.432 |
CK1E |
0.786 | -0.032 | -3 | 0.536 |
SGK3 |
0.786 | -0.043 | -3 | 0.770 |
PKG2 |
0.786 | -0.050 | -2 | 0.620 |
PAK6 |
0.785 | -0.059 | -2 | 0.659 |
CAMK1D |
0.785 | 0.036 | -3 | 0.693 |
NEK5 |
0.785 | -0.139 | 1 | 0.639 |
PAK2 |
0.785 | -0.125 | -2 | 0.721 |
CDK9 |
0.785 | -0.074 | 1 | 0.505 |
TAO3 |
0.784 | -0.069 | 1 | 0.609 |
GRK3 |
0.784 | -0.030 | -2 | 0.670 |
GSK3A |
0.784 | 0.012 | 4 | 0.432 |
MEKK3 |
0.784 | -0.204 | 1 | 0.609 |
SNRK |
0.783 | -0.188 | 2 | 0.554 |
MEKK2 |
0.783 | -0.161 | 2 | 0.673 |
DCAMKL2 |
0.783 | -0.054 | -3 | 0.820 |
GAK |
0.782 | -0.014 | 1 | 0.658 |
WNK4 |
0.782 | -0.166 | -2 | 0.845 |
CDK14 |
0.782 | -0.041 | 1 | 0.486 |
PINK1 |
0.782 | -0.182 | 1 | 0.641 |
HIPK3 |
0.782 | -0.047 | 1 | 0.538 |
ZAK |
0.782 | -0.203 | 1 | 0.603 |
SMMLCK |
0.782 | -0.063 | -3 | 0.810 |
CK1D |
0.781 | -0.016 | -3 | 0.480 |
JNK1 |
0.781 | -0.009 | 1 | 0.470 |
DYRK3 |
0.781 | -0.019 | 1 | 0.558 |
DAPK3 |
0.781 | 0.040 | -3 | 0.805 |
MEK5 |
0.780 | -0.317 | 2 | 0.694 |
PKACA |
0.780 | 0.000 | -2 | 0.564 |
MPSK1 |
0.779 | -0.075 | 1 | 0.594 |
IRAK4 |
0.779 | -0.169 | 1 | 0.619 |
AKT1 |
0.779 | -0.016 | -3 | 0.723 |
GSK3B |
0.779 | -0.035 | 4 | 0.423 |
NEK8 |
0.777 | -0.158 | 2 | 0.691 |
CAMKK1 |
0.777 | -0.132 | -2 | 0.778 |
IRAK1 |
0.777 | -0.192 | -1 | 0.738 |
TTBK1 |
0.776 | -0.164 | 2 | 0.537 |
PHKG2 |
0.776 | -0.107 | -3 | 0.804 |
MST3 |
0.776 | -0.151 | 2 | 0.704 |
ERK7 |
0.776 | -0.035 | 2 | 0.459 |
TAO2 |
0.775 | -0.127 | 2 | 0.739 |
PKCT |
0.775 | -0.107 | 2 | 0.613 |
EEF2K |
0.775 | -0.023 | 3 | 0.777 |
P70S6K |
0.774 | -0.056 | -3 | 0.711 |
CK1G1 |
0.774 | -0.087 | -3 | 0.527 |
ALPHAK3 |
0.774 | 0.230 | -1 | 0.796 |
CDK10 |
0.773 | -0.037 | 1 | 0.477 |
LKB1 |
0.773 | -0.123 | -3 | 0.811 |
MST2 |
0.773 | -0.103 | 1 | 0.627 |
CAMKK2 |
0.773 | -0.119 | -2 | 0.761 |
CK1A2 |
0.773 | -0.050 | -3 | 0.482 |
PDK1 |
0.773 | -0.121 | 1 | 0.631 |
TAK1 |
0.772 | -0.095 | 1 | 0.666 |
GCK |
0.772 | -0.102 | 1 | 0.605 |
DAPK1 |
0.771 | -0.001 | -3 | 0.784 |
MAK |
0.770 | 0.030 | -2 | 0.721 |
CAMK1A |
0.769 | 0.003 | -3 | 0.665 |
PDHK3_TYR |
0.769 | 0.214 | 4 | 0.870 |
NEK11 |
0.769 | -0.267 | 1 | 0.605 |
TNIK |
0.768 | -0.085 | 3 | 0.808 |
PKCI |
0.768 | -0.120 | 2 | 0.621 |
NEK4 |
0.767 | -0.210 | 1 | 0.597 |
MINK |
0.767 | -0.142 | 1 | 0.598 |
PKCE |
0.766 | -0.066 | 2 | 0.611 |
CDK4 |
0.766 | -0.048 | 1 | 0.466 |
HGK |
0.766 | -0.140 | 3 | 0.804 |
SBK |
0.766 | 0.033 | -3 | 0.593 |
LRRK2 |
0.765 | -0.190 | 2 | 0.724 |
NEK1 |
0.765 | -0.164 | 1 | 0.610 |
CDK6 |
0.765 | -0.054 | 1 | 0.471 |
AKT3 |
0.765 | -0.009 | -3 | 0.645 |
MAP3K15 |
0.764 | -0.200 | 1 | 0.584 |
SGK1 |
0.764 | -0.004 | -3 | 0.627 |
ROCK2 |
0.763 | -0.009 | -3 | 0.793 |
TTK |
0.763 | 0.010 | -2 | 0.871 |
MOK |
0.763 | -0.008 | 1 | 0.560 |
VRK1 |
0.763 | -0.205 | 2 | 0.719 |
PKN1 |
0.763 | -0.081 | -3 | 0.733 |
MST1 |
0.762 | -0.146 | 1 | 0.598 |
CHK2 |
0.762 | -0.043 | -3 | 0.654 |
EPHA6 |
0.761 | 0.172 | -1 | 0.857 |
PDHK4_TYR |
0.761 | 0.112 | 2 | 0.782 |
PAK5 |
0.761 | -0.112 | -2 | 0.579 |
KHS1 |
0.760 | -0.096 | 1 | 0.592 |
HPK1 |
0.760 | -0.151 | 1 | 0.590 |
PAK4 |
0.760 | -0.095 | -2 | 0.586 |
MRCKB |
0.760 | -0.035 | -3 | 0.741 |
BUB1 |
0.760 | -0.026 | -5 | 0.711 |
KHS2 |
0.759 | -0.069 | 1 | 0.597 |
MRCKA |
0.759 | -0.044 | -3 | 0.758 |
MEKK6 |
0.758 | -0.253 | 1 | 0.601 |
SLK |
0.758 | -0.116 | -2 | 0.689 |
MAP2K6_TYR |
0.758 | 0.065 | -1 | 0.877 |
LOK |
0.757 | -0.166 | -2 | 0.745 |
TESK1_TYR |
0.757 | -0.042 | 3 | 0.840 |
MAP2K4_TYR |
0.757 | 0.006 | -1 | 0.871 |
DMPK1 |
0.757 | 0.003 | -3 | 0.771 |
STK33 |
0.756 | -0.185 | 2 | 0.529 |
EPHA4 |
0.756 | 0.204 | 2 | 0.733 |
EPHB4 |
0.756 | 0.124 | -1 | 0.841 |
PDHK1_TYR |
0.756 | 0.050 | -1 | 0.886 |
RIPK2 |
0.756 | -0.277 | 1 | 0.569 |
PBK |
0.754 | -0.105 | 1 | 0.583 |
MEK2 |
0.754 | -0.263 | 2 | 0.668 |
YSK1 |
0.753 | -0.190 | 2 | 0.678 |
BMPR2_TYR |
0.753 | -0.017 | -1 | 0.860 |
TXK |
0.752 | 0.137 | 1 | 0.724 |
FER |
0.752 | 0.123 | 1 | 0.765 |
PKMYT1_TYR |
0.751 | -0.126 | 3 | 0.812 |
MAP2K7_TYR |
0.751 | -0.177 | 2 | 0.755 |
OSR1 |
0.750 | -0.124 | 2 | 0.660 |
EPHB2 |
0.750 | 0.172 | -1 | 0.820 |
BIKE |
0.749 | -0.051 | 1 | 0.549 |
YANK3 |
0.749 | -0.066 | 2 | 0.373 |
CRIK |
0.749 | -0.009 | -3 | 0.721 |
PINK1_TYR |
0.749 | -0.161 | 1 | 0.674 |
EPHB3 |
0.748 | 0.129 | -1 | 0.830 |
SRMS |
0.748 | 0.142 | 1 | 0.751 |
EPHB1 |
0.746 | 0.087 | 1 | 0.733 |
ASK1 |
0.746 | -0.179 | 1 | 0.585 |
BLK |
0.746 | 0.127 | -1 | 0.817 |
ROCK1 |
0.746 | -0.044 | -3 | 0.756 |
NEK3 |
0.745 | -0.250 | 1 | 0.570 |
LIMK2_TYR |
0.745 | -0.112 | -3 | 0.870 |
ABL2 |
0.745 | -0.006 | -1 | 0.808 |
LCK |
0.744 | 0.063 | -1 | 0.818 |
RET |
0.744 | -0.150 | 1 | 0.621 |
TYRO3 |
0.744 | -0.077 | 3 | 0.763 |
INSRR |
0.743 | -0.003 | 3 | 0.725 |
CSF1R |
0.743 | -0.086 | 3 | 0.756 |
HCK |
0.743 | 0.016 | -1 | 0.812 |
HASPIN |
0.743 | -0.109 | -1 | 0.650 |
TYK2 |
0.742 | -0.192 | 1 | 0.626 |
YES1 |
0.742 | -0.001 | -1 | 0.829 |
PKG1 |
0.742 | -0.088 | -2 | 0.521 |
MST1R |
0.742 | -0.164 | 3 | 0.782 |
EPHA7 |
0.742 | 0.116 | 2 | 0.726 |
ROS1 |
0.741 | -0.120 | 3 | 0.731 |
MYO3B |
0.741 | -0.160 | 2 | 0.683 |
JAK2 |
0.741 | -0.164 | 1 | 0.620 |
EPHA5 |
0.740 | 0.168 | 2 | 0.726 |
TAO1 |
0.740 | -0.167 | 1 | 0.545 |
FGR |
0.740 | -0.085 | 1 | 0.657 |
DDR1 |
0.740 | -0.124 | 4 | 0.787 |
MYO3A |
0.740 | -0.165 | 1 | 0.594 |
LIMK1_TYR |
0.740 | -0.208 | 2 | 0.740 |
CK1A |
0.740 | -0.062 | -3 | 0.393 |
ITK |
0.739 | -0.014 | -1 | 0.791 |
TEC |
0.737 | 0.030 | -1 | 0.730 |
JAK3 |
0.737 | -0.128 | 1 | 0.619 |
ABL1 |
0.737 | -0.057 | -1 | 0.800 |
TNK2 |
0.737 | -0.057 | 3 | 0.734 |
FGFR2 |
0.737 | -0.082 | 3 | 0.762 |
FYN |
0.736 | 0.062 | -1 | 0.794 |
KIT |
0.736 | -0.096 | 3 | 0.761 |
BMX |
0.735 | 0.003 | -1 | 0.712 |
EPHA3 |
0.735 | 0.001 | 2 | 0.699 |
FLT3 |
0.734 | -0.128 | 3 | 0.755 |
MERTK |
0.734 | -0.026 | 3 | 0.737 |
AAK1 |
0.734 | -0.024 | 1 | 0.455 |
LYN |
0.733 | 0.024 | 3 | 0.681 |
FGFR1 |
0.733 | -0.113 | 3 | 0.735 |
TEK |
0.733 | -0.058 | 3 | 0.705 |
PDGFRB |
0.733 | -0.171 | 3 | 0.769 |
MET |
0.732 | -0.085 | 3 | 0.760 |
FRK |
0.731 | -0.001 | -1 | 0.821 |
AXL |
0.731 | -0.084 | 3 | 0.747 |
EPHA8 |
0.731 | 0.052 | -1 | 0.812 |
BTK |
0.731 | -0.092 | -1 | 0.750 |
SYK |
0.730 | 0.122 | -1 | 0.780 |
KDR |
0.729 | -0.149 | 3 | 0.719 |
PTK2 |
0.729 | 0.042 | -1 | 0.774 |
JAK1 |
0.729 | -0.151 | 1 | 0.569 |
ALK |
0.728 | -0.086 | 3 | 0.690 |
PTK2B |
0.728 | -0.002 | -1 | 0.767 |
LTK |
0.728 | -0.079 | 3 | 0.702 |
NTRK1 |
0.727 | -0.123 | -1 | 0.823 |
EPHA1 |
0.727 | -0.033 | 3 | 0.731 |
FGFR3 |
0.727 | -0.091 | 3 | 0.744 |
TNNI3K_TYR |
0.727 | -0.130 | 1 | 0.626 |
STLK3 |
0.727 | -0.252 | 1 | 0.567 |
EGFR |
0.727 | -0.025 | 1 | 0.528 |
NEK10_TYR |
0.726 | -0.170 | 1 | 0.521 |
ERBB2 |
0.726 | -0.127 | 1 | 0.603 |
FLT1 |
0.726 | -0.115 | -1 | 0.843 |
PTK6 |
0.725 | -0.114 | -1 | 0.749 |
TNK1 |
0.725 | -0.169 | 3 | 0.746 |
INSR |
0.725 | -0.112 | 3 | 0.711 |
EPHA2 |
0.724 | 0.061 | -1 | 0.774 |
PDGFRA |
0.723 | -0.246 | 3 | 0.760 |
WEE1_TYR |
0.723 | -0.143 | -1 | 0.758 |
CK1G3 |
0.723 | -0.049 | -3 | 0.345 |
SRC |
0.722 | -0.035 | -1 | 0.795 |
FGFR4 |
0.721 | -0.045 | -1 | 0.786 |
NTRK2 |
0.721 | -0.181 | 3 | 0.728 |
NTRK3 |
0.721 | -0.109 | -1 | 0.787 |
DDR2 |
0.721 | -0.065 | 3 | 0.710 |
FLT4 |
0.720 | -0.185 | 3 | 0.702 |
CSK |
0.719 | -0.097 | 2 | 0.716 |
MATK |
0.719 | -0.094 | -1 | 0.748 |
ERBB4 |
0.717 | -0.017 | 1 | 0.573 |
YANK2 |
0.715 | -0.090 | 2 | 0.398 |
IGF1R |
0.712 | -0.092 | 3 | 0.657 |
CK1G2 |
0.704 | -0.058 | -3 | 0.440 |
MUSK |
0.704 | -0.174 | 1 | 0.501 |
FES |
0.700 | -0.074 | -1 | 0.703 |
ZAP70 |
0.696 | -0.046 | -1 | 0.705 |