Motif 746 (n=210)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S686 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A0AVT1 | UBA6 | S951 | ochoa | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| A2RRD8 | ZNF320 | S452 | ochoa | Zinc finger protein 320 | May be involved in transcriptional regulation. |
| A2VDJ0 | TMEM131L | S1276 | ochoa | Transmembrane protein 131-like | [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000269|PubMed:23690469}. |
| A5PL33 | KRBA1 | S447 | ochoa | Protein KRBA1 | None |
| A8MT19 | RHPN2P1 | S496 | ochoa | Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1) | None |
| O00151 | PDLIM1 | S123 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00151 | PDLIM1 | S187 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00273 | DFFA | S233 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O00515 | LAD1 | S272 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14578 | CIT | S1305 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14641 | DVL2 | S228 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14654 | IRS4 | S1091 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15027 | SEC16A | S1801 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15061 | SYNM | S484 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O60237 | PPP1R12B | S523 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60506 | SYNCRIP | S55 | ochoa | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}. |
| O60664 | PLIN3 | S148 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60934 | NBN | S612 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75152 | ZC3H11A | S533 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75152 | ZC3H11A | S688 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75363 | BCAS1 | S535 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75469 | NR1I2 | S167 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O75717 | WDHD1 | S1041 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O95292 | VAPB | S142 | ochoa | Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| O95376 | ARIH2 | S353 | ochoa | E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:30587576, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:38418882}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:31253590, ECO:0000269|PubMed:36754086}. |
| O95772 | STARD3NL | S193 | ochoa | STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog) | Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}. |
| P04350 | TUBB4A | S339 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05023 | ATP1A1 | S653 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P07437 | TUBB | S339 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07451 | CA3 | S218 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P07942 | LAMB1 | S1666 | ochoa | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P0DMV8 | HSPA1A | S418 | ochoa|psp | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S418 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P10586 | PTPRF | S1311 | ochoa | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| P11171 | EPB41 | S712 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11387 | TOP1 | S394 | ochoa|psp | DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter. {ECO:0000250|UniProtKB:Q13472, ECO:0000269|PubMed:14594810, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:22904072, ECO:0000269|PubMed:2833744}. |
| P13637 | ATP1A3 | S643 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P15311 | EZR | S536 | ochoa | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P16144 | ITGB4 | S1000 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P19367 | HK1 | S124 | psp | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P22102 | GART | S621 | ochoa | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| P23025 | XPA | S173 | psp | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769). {ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:31253769}. |
| P23769 | GATA2 | S220 | ochoa | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
| P26038 | MSN | S527 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P27448 | MARK3 | S499 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P27694 | RPA1 | S432 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P31327 | CPS1 | S468 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P34931 | HSPA1L | S420 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35241 | RDX | S533 | ochoa | Radixin | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| P37840 | SNCA | S42 | ochoa | Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}. |
| P39880 | CUX1 | S409 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41743 | PRKCI | S459 | ochoa|psp | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P42336 | PIK3CA | S507 | ochoa | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396, PubMed:28676499). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:23936502, PubMed:28676499). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). {ECO:0000250|UniProtKB:P42337, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:21708979, ECO:0000269|PubMed:23936502, ECO:0000269|PubMed:26593112, ECO:0000269|PubMed:28676499}. |
| P42356 | PI4KA | S763 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
| P42892 | ECE1 | S51 | ochoa | Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) | Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:37835445, ECO:0000269|PubMed:9396733}. |
| P43005 | SLC1A1 | S477 | ochoa | Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:21123949, PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed:7914198, PubMed:8857541). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed:8857541). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:26690923, PubMed:8857541). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:33658209, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}. |
| P46013 | MKI67 | S2769 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46087 | NOP2 | S674 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46937 | YAP1 | S436 | psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P47736 | RAP1GAP | S525 | psp | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49327 | FASN | S1717 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P50991 | CCT4 | S236 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P53675 | CLTCL1 | S1222 | ochoa | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
| P54132 | BLM | S502 | psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54296 | MYOM2 | S1228 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55040 | GEM | S261 | psp | GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) | Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. |
| P55199 | ELL | S519 | ochoa | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| P60520 | GABARAPL2 | S87 | psp | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein) | Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295). {ECO:0000250|UniProtKB:P60519, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}. |
| P61247 | RPS3A | S238 | ochoa | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P61981 | YWHAG | S150 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P68371 | TUBB4B | S339 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q00610 | CLTC | S1222 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q05209 | PTPN12 | S556 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05655 | PRKCD | S331 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q06187 | BTK | S55 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q08AD1 | CAMSAP2 | S716 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q13136 | PPFIA1 | S839 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13418 | ILK | S343 | psp | Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) | Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:16517730, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:18283114, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:30367047, ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:9736715}. |
| Q13509 | TUBB3 | S339 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13523 | PRP4K | S839 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13526 | PIN1 | S65 | psp | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13526 | PIN1 | S115 | ochoa|psp | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13571 | LAPTM5 | S238 | ochoa | Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein) | May have a special functional role during embryogenesis and in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}. |
| Q13885 | TUBB2A | S339 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14207 | NPAT | S377 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14315 | FLNC | S379 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14692 | BMS1 | S49 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q14980 | NUMA1 | S1187 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15058 | KIF14 | S173 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15554 | TERF2 | S421 | ochoa | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}. |
| Q15554 | TERF2 | S422 | ochoa | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}. |
| Q15596 | NCOA2 | S699 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15796 | SMAD2 | S417 | psp | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q16143 | SNCB | S42 | ochoa | Beta-synuclein | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Q16658 | FSCN1 | S120 | ochoa | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| Q29RF7 | PDS5A | S1177 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2M2Z5 | KIZ | S507 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q32MZ4 | LRRFIP1 | S768 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q49MG5 | MAP9 | S289 | ochoa|psp | Microtubule-associated protein 9 (Aster-associated protein) | Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. {ECO:0000269|PubMed:16049101}. |
| Q4G0A6 | MINDY4 | S524 | ochoa | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4) | Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000250|UniProtKB:Q8NBR6}. |
| Q52LW3 | ARHGAP29 | S489 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5FBB7 | SGO1 | S38 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5JSZ5 | PRRC2B | S1291 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T011 | SZT2 | S2143 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T0W9 | FAM83B | S566 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T5P2 | KIAA1217 | S610 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TBA9 | FRY | S2350 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5UIP0 | RIF1 | S1494 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5XKL5 | BTBD8 | S879 | ochoa | BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) | Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. {ECO:0000250|UniProtKB:Q80TK0}. |
| Q6NUJ5 | PWWP2B | S43 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6NYC8 | PPP1R18 | S308 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P4R8 | NFRKB | S494 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6P6B1 | ERICH5 | S169 | ochoa | Glutamate-rich protein 5 | None |
| Q6TDP4 | KLHL17 | S374 | ochoa | Kelch-like protein 17 (Actinfilin) | Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}. |
| Q6ZN28 | MACC1 | S19 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q6ZVL6 | KIAA1549L | S1536 | ochoa | UPF0606 protein KIAA1549L | None |
| Q71DI3 | H3C15 | S88 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q76FK4 | NOL8 | S329 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q76N32 | CEP68 | S226 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7Z417 | NUFIP2 | S608 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q86SQ0 | PHLDB2 | S965 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UW6 | N4BP2 | S1216 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q86VF7 | NRAP | S729 | ochoa | Nebulin-related-anchoring protein (N-RAP) | May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}. |
| Q86XP1 | DGKH | S608 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q86YH2 | ZNF280B | S111 | ochoa | Zinc finger protein 280B (5'OY11.1) (Suppressor of hairy wing homolog 2) (Zinc finger protein 279) (Zinc finger protein 632) | May function as a transcription factor. |
| Q8IUC4 | RHPN2 | S599 | ochoa | Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
| Q8IX90 | SKA3 | S248 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8IXI1 | RHOT2 | S156 | psp | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8IXI2 | RHOT1 | S156 | psp | Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788). Can hydrolyze GTP, ATP and UTP (PubMed:30513825). {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27716788, ECO:0000269|PubMed:30513825}. |
| Q8IYD8 | FANCM | S1758 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8NAP3 | ZBTB38 | S244 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NCN4 | RNF169 | S472 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NHV4 | NEDD1 | S496 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TD19 | NEK9 | S331 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TDY2 | RB1CC1 | S229 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TF72 | SHROOM3 | S1726 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q92481 | TFAP2B | S242 | ochoa | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
| Q92508 | PIEZO1 | S393 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92551 | IP6K1 | S175 | ochoa | Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
| Q96DU3 | SLAMF6 | S287 | ochoa | SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:16920955, PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q9ET39, ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}. |
| Q96QS3 | ARX | S314 | ochoa | Homeobox protein ARX (Aristaless-related homeobox) | Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14722918, ECO:0000269|PubMed:22194193, ECO:0000269|PubMed:31691806}. |
| Q9BUF5 | TUBB6 | S339 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S339 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BXS4 | TMEM59 | S295 | ochoa | Transmembrane protein 59 (Liver membrane-bound protein) | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:23376921, PubMed:27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}. |
| Q9BZE2 | PUS3 | S45 | ochoa | tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3) | Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. {ECO:0000269|PubMed:27055666}. |
| Q9C0G0 | ZNF407 | S994 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9GZR2 | REXO4 | S383 | ochoa | RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) | None |
| Q9H0A0 | NAT10 | S674 | ochoa | RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) | RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}. |
| Q9H2G2 | SLK | S655 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H3C7 | GGNBP2 | S414 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
| Q9H6X4 | TMEM134 | S53 | ochoa | Transmembrane protein 134 | None |
| Q9H8V3 | ECT2 | S716 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H8X2 | IPPK | S109 | ochoa | Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}. |
| Q9HCK1 | ZDBF2 | S535 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NQT8 | KIF13B | S661 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NR30 | DDX21 | S567 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NR45 | NANS | S134 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
| Q9NUE0 | ZDHHC18 | S171 | ochoa | Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}. |
| Q9NWH9 | SLTM | S789 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NZJ0 | DTL | S410 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9UER7 | DAXX | S671 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UHD8 | SEPTIN9 | S238 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UK76 | JPT1 | S70 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9UKJ3 | GPATCH8 | S1109 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKX2 | MYH2 | S20 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULQ1 | TPCN1 | S796 | ochoa | Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) | Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946). {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:23394946, ECO:0000269|PubMed:24776928, ECO:0000305|PubMed:32679067}.; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. {ECO:0000269|PubMed:25722412}. |
| Q9UNZ2 | NSFL1C | S62 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPN4 | CEP131 | S208 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPU5 | USP24 | S1305 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UQC2 | GAB2 | S218 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9UQM7 | CAMK2A | S257 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y485 | DMXL1 | S466 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y666 | SLC12A7 | S62 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9Y6N9 | USH1C | S287 | ochoa | Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) | Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018}. |
| Q9Y6Q9 | NCOA3 | S694 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P27348 | YWHAQ | S145 | Sugiyama | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P62258 | YWHAE | S148 | Sugiyama | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S145 | Sugiyama | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| Q04917 | YWHAH | S150 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| O00444 | PLK4 | S640 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| P20618 | PSMB1 | S157 | Sugiyama | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P36871 | PGM1 | S483 | Sugiyama | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P60174 | TPI1 | S198 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P61313 | RPL15 | S118 | Sugiyama | Large ribosomal subunit protein eL15 (60S ribosomal protein L15) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P08236 | GUSB | S46 | Sugiyama | Beta-glucuronidase (EC 3.2.1.31) (Beta-G1) | Plays an important role in the degradation of dermatan and keratan sulfates. |
| P23381 | WARS1 | S213 | Sugiyama | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}. |
| P33316 | DUT | S164 | Sugiyama | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}. |
| P61163 | ACTR1A | S331 | Sugiyama | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}. |
| Q04446 | GBE1 | S75 | Sugiyama | 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme) | Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer (PubMed:26199317, PubMed:8463281, PubMed:8613547). {ECO:0000269|PubMed:26199317, ECO:0000269|PubMed:8463281, ECO:0000269|PubMed:8613547}. |
| Q9H6F5 | CCDC86 | S136 | Sugiyama | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| P13861 | PRKAR2A | S307 | Sugiyama | cAMP-dependent protein kinase type II-alpha regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| O60566 | BUB1B | S225 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| P43034 | PAFAH1B1 | S157 | Sugiyama | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
| O00232 | PSMD12 | S21 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| P31946 | YWHAB | S147 | Sugiyama | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| Q9NSE4 | IARS2 | S98 | Sugiyama | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile)). {ECO:0000250|UniProtKB:P00956}. |
| P11047 | LAMC1 | S348 | Sugiyama | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P57081 | WDR4 | S128 | Sugiyama | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) | Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985, PubMed:37369656). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding (PubMed:36599982, PubMed:36599985, PubMed:37369656). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352206, PubMed:34352207, PubMed:36599982, PubMed:36599985, PubMed:37369656). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084, PubMed:37379838). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069). {ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084, ECO:0000269|PubMed:34352206, ECO:0000269|PubMed:34352207, ECO:0000269|PubMed:36599982, ECO:0000269|PubMed:36599985, ECO:0000269|PubMed:37369656, ECO:0000269|PubMed:37379838}. |
| P42684 | ABL2 | S146 | Sugiyama | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| Q13144 | EIF2B5 | S51 | iPTMNet | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q92609 | TBC1D5 | S677 | Sugiyama | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q13043 | STK4 | S65 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13188 | STK3 | S62 | Sugiyama | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| P80303 | NUCB2 | S96 | Sugiyama | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| P11498 | PC | S122 | Sugiyama | Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. {ECO:0000269|PubMed:9585002}. |
| P00813 | ADA | S291 | Sugiyama | Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697). {ECO:0000250|UniProtKB:P03958, ECO:0000250|UniProtKB:P56658, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:15016824, ECO:0000269|PubMed:16670267, ECO:0000269|PubMed:20959412, ECO:0000269|PubMed:21919946, ECO:0000269|PubMed:23193172, ECO:0000269|PubMed:26038697, ECO:0000269|PubMed:26166670, ECO:0000269|PubMed:8452534, ECO:0000269|PubMed:9361033}. |
| Q8NEZ2 | VPS37A | S326 | Sugiyama | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}. |
| Q15047 | SETDB1 | S86 | Sugiyama | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| O43815 | STRN | S301 | Sugiyama | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.696243e-14 | 13.328 |
| R-HSA-3371556 | Cellular response to heat stress | 1.001421e-13 | 12.999 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.502132e-12 | 11.187 |
| R-HSA-68877 | Mitotic Prometaphase | 2.870090e-10 | 9.542 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.792957e-10 | 9.056 |
| R-HSA-69275 | G2/M Transition | 1.080492e-09 | 8.966 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.263854e-09 | 8.898 |
| R-HSA-437239 | Recycling pathway of L1 | 1.891351e-09 | 8.723 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.589201e-09 | 8.587 |
| R-HSA-9833482 | PKR-mediated signaling | 2.321009e-08 | 7.634 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.971310e-08 | 7.304 |
| R-HSA-2262752 | Cellular responses to stress | 5.674630e-08 | 7.246 |
| R-HSA-1640170 | Cell Cycle | 6.146804e-08 | 7.211 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 8.019998e-08 | 7.096 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.080255e-07 | 6.966 |
| R-HSA-68886 | M Phase | 1.457883e-07 | 6.836 |
| R-HSA-190828 | Gap junction trafficking | 1.907272e-07 | 6.720 |
| R-HSA-373760 | L1CAM interactions | 2.095192e-07 | 6.679 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.598192e-07 | 6.585 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.598192e-07 | 6.585 |
| R-HSA-5617833 | Cilium Assembly | 2.970873e-07 | 6.527 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.264734e-07 | 6.486 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.772402e-07 | 6.423 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 3.800342e-07 | 6.420 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.071826e-07 | 6.390 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.052831e-07 | 6.296 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 6.321507e-07 | 6.199 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 7.215683e-07 | 6.142 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 7.215683e-07 | 6.142 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 7.215683e-07 | 6.142 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 8.465731e-07 | 6.072 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 9.239311e-07 | 6.034 |
| R-HSA-380287 | Centrosome maturation | 1.051347e-06 | 5.978 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.413386e-06 | 5.850 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.439549e-06 | 5.842 |
| R-HSA-2028269 | Signaling by Hippo | 1.672022e-06 | 5.777 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.168971e-06 | 5.664 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.500194e-06 | 5.602 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.461851e-06 | 5.461 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.519471e-06 | 5.454 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.469447e-06 | 5.350 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.470072e-06 | 5.350 |
| R-HSA-190861 | Gap junction assembly | 4.863845e-06 | 5.313 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.927139e-06 | 5.307 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.658323e-06 | 5.116 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.803063e-06 | 5.108 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.119856e-06 | 5.090 |
| R-HSA-9646399 | Aggrephagy | 1.168439e-05 | 4.932 |
| R-HSA-9675108 | Nervous system development | 1.224329e-05 | 4.912 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.230540e-05 | 4.910 |
| R-HSA-422475 | Axon guidance | 1.283420e-05 | 4.892 |
| R-HSA-983189 | Kinesins | 1.506573e-05 | 4.822 |
| R-HSA-69481 | G2/M Checkpoints | 1.949988e-05 | 4.710 |
| R-HSA-199991 | Membrane Trafficking | 2.442532e-05 | 4.612 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.618462e-05 | 4.582 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.673730e-05 | 4.573 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.158087e-05 | 4.501 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.424906e-05 | 4.465 |
| R-HSA-109581 | Apoptosis | 3.514942e-05 | 4.454 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.314612e-05 | 4.365 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.410972e-05 | 4.267 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.568650e-05 | 4.121 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.899244e-05 | 4.102 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 8.013883e-05 | 4.096 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.029698e-05 | 4.044 |
| R-HSA-9612973 | Autophagy | 1.178074e-04 | 3.929 |
| R-HSA-68882 | Mitotic Anaphase | 1.132134e-04 | 3.946 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.179790e-04 | 3.928 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.411288e-04 | 3.850 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.567678e-04 | 3.805 |
| R-HSA-9663891 | Selective autophagy | 1.752315e-04 | 3.756 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.037548e-04 | 3.691 |
| R-HSA-1632852 | Macroautophagy | 2.369794e-04 | 3.625 |
| R-HSA-5357801 | Programmed Cell Death | 2.762115e-04 | 3.559 |
| R-HSA-5620924 | Intraflagellar transport | 2.920661e-04 | 3.535 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.969068e-04 | 3.527 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.361935e-04 | 3.473 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.361935e-04 | 3.473 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.793657e-04 | 3.319 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 5.227792e-04 | 3.282 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.484415e-04 | 3.261 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.867049e-04 | 3.232 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.988363e-04 | 3.156 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 9.078102e-04 | 3.042 |
| R-HSA-391251 | Protein folding | 1.282652e-03 | 2.892 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.354894e-03 | 2.868 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.504355e-03 | 2.823 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.709905e-03 | 2.767 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.820343e-03 | 2.740 |
| R-HSA-913531 | Interferon Signaling | 2.056076e-03 | 2.687 |
| R-HSA-9609690 | HCMV Early Events | 2.389445e-03 | 2.622 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.884957e-03 | 2.540 |
| R-HSA-162582 | Signal Transduction | 3.209810e-03 | 2.494 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.556374e-03 | 2.449 |
| R-HSA-5660489 | MTF1 activates gene expression | 4.159149e-03 | 2.381 |
| R-HSA-9609646 | HCMV Infection | 4.019820e-03 | 2.396 |
| R-HSA-392517 | Rap1 signalling | 6.693861e-03 | 2.174 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 7.852102e-03 | 2.105 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.928920e-03 | 2.101 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.911579e-03 | 2.050 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.073535e-03 | 2.042 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 1.115473e-02 | 1.953 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.192649e-02 | 1.923 |
| R-HSA-196025 | Formation of annular gap junctions | 1.327900e-02 | 1.877 |
| R-HSA-3000157 | Laminin interactions | 1.331886e-02 | 1.876 |
| R-HSA-9824446 | Viral Infection Pathways | 1.425365e-02 | 1.846 |
| R-HSA-912446 | Meiotic recombination | 1.463365e-02 | 1.835 |
| R-HSA-190873 | Gap junction degradation | 1.564211e-02 | 1.806 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.564211e-02 | 1.806 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 1.570568e-02 | 1.804 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.581099e-02 | 1.801 |
| R-HSA-1500620 | Meiosis | 1.648348e-02 | 1.783 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.653036e-02 | 1.782 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.085990e-02 | 1.681 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.831758e-02 | 1.737 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.085990e-02 | 1.681 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.908303e-02 | 1.719 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.095265e-02 | 1.679 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.422172e-02 | 1.616 |
| R-HSA-1266738 | Developmental Biology | 2.462612e-02 | 1.609 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.583974e-02 | 1.588 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.093604e-02 | 1.510 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.093604e-02 | 1.510 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.093604e-02 | 1.510 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 3.093604e-02 | 1.510 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.093604e-02 | 1.510 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.093604e-02 | 1.510 |
| R-HSA-5673000 | RAF activation | 2.751445e-02 | 1.560 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.983203e-02 | 1.525 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.103339e-02 | 1.508 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.751445e-02 | 1.560 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.751445e-02 | 1.560 |
| R-HSA-111933 | Calmodulin induced events | 3.103339e-02 | 1.508 |
| R-HSA-111997 | CaM pathway | 3.103339e-02 | 1.508 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.924572e-02 | 1.534 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 2.983203e-02 | 1.525 |
| R-HSA-8853659 | RET signaling | 3.103339e-02 | 1.508 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.093197e-02 | 1.510 |
| R-HSA-4641258 | Degradation of DVL | 3.287725e-02 | 1.483 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.288916e-02 | 1.483 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 3.310686e-02 | 1.480 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.477705e-02 | 1.459 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.504446e-02 | 1.455 |
| R-HSA-212436 | Generic Transcription Pathway | 3.580676e-02 | 1.446 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.651523e-02 | 1.438 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.292954e-02 | 1.367 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.292954e-02 | 1.367 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 4.005222e-02 | 1.397 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.080911e-02 | 1.389 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 4.005222e-02 | 1.397 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.874331e-02 | 1.412 |
| R-HSA-9607240 | FLT3 Signaling | 4.080911e-02 | 1.389 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.151050e-02 | 1.382 |
| R-HSA-74160 | Gene expression (Transcription) | 4.267450e-02 | 1.370 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.484230e-02 | 1.348 |
| R-HSA-5660526 | Response to metal ions | 4.371303e-02 | 1.359 |
| R-HSA-111996 | Ca-dependent events | 4.510417e-02 | 1.346 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.510417e-02 | 1.346 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.545855e-02 | 1.342 |
| R-HSA-2206292 | MPS VII - Sly syndrome (Hyaluronan metabolism) | 4.604470e-02 | 1.337 |
| R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | 4.604470e-02 | 1.337 |
| R-HSA-9953080 | MPS VII - Sly syndrome (CS/DS degradation) | 4.604470e-02 | 1.337 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 4.604470e-02 | 1.337 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 4.604470e-02 | 1.337 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 4.604470e-02 | 1.337 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 4.604470e-02 | 1.337 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 4.604470e-02 | 1.337 |
| R-HSA-112316 | Neuronal System | 4.703994e-02 | 1.328 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 4.749296e-02 | 1.323 |
| R-HSA-4086400 | PCP/CE pathway | 4.790302e-02 | 1.320 |
| R-HSA-9659379 | Sensory processing of sound | 4.958163e-02 | 1.305 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.961430e-02 | 1.304 |
| R-HSA-9734735 | Defective ADA disrupts (deoxy)adenosine deamination | 6.091872e-02 | 1.215 |
| R-HSA-3878781 | Glycogen storage disease type IV (GBE1) | 6.091872e-02 | 1.215 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 5.539205e-02 | 1.257 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 5.950239e-02 | 1.225 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.950239e-02 | 1.225 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.950239e-02 | 1.225 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 5.950239e-02 | 1.225 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.433570e-02 | 1.265 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.433570e-02 | 1.265 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.433570e-02 | 1.265 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.433570e-02 | 1.265 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.194884e-02 | 1.284 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 6.091872e-02 | 1.215 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.194884e-02 | 1.284 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.345649e-02 | 1.272 |
| R-HSA-3322077 | Glycogen synthesis | 5.950239e-02 | 1.225 |
| R-HSA-75153 | Apoptotic execution phase | 5.433570e-02 | 1.265 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.032427e-02 | 1.220 |
| R-HSA-9675135 | Diseases of DNA repair | 5.433570e-02 | 1.265 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.415835e-02 | 1.193 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 6.802346e-02 | 1.167 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.972400e-02 | 1.157 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 7.556172e-02 | 1.122 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 7.556172e-02 | 1.122 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 8.997728e-02 | 1.046 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 8.997728e-02 | 1.046 |
| R-HSA-5619067 | Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic ami... | 1.041689e-01 | 0.982 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 1.041689e-01 | 0.982 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.181401e-01 | 0.928 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.318943e-01 | 0.880 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.318943e-01 | 0.880 |
| R-HSA-9645135 | STAT5 Activation | 1.318943e-01 | 0.880 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.454347e-01 | 0.837 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.454347e-01 | 0.837 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.454347e-01 | 0.837 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.454347e-01 | 0.837 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.454347e-01 | 0.837 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.587648e-01 | 0.799 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.587648e-01 | 0.799 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.587648e-01 | 0.799 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.587648e-01 | 0.799 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.587648e-01 | 0.799 |
| R-HSA-9613354 | Lipophagy | 1.718878e-01 | 0.765 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.718878e-01 | 0.765 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.848068e-01 | 0.733 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.848068e-01 | 0.733 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.848068e-01 | 0.733 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.100457e-01 | 0.678 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 2.100457e-01 | 0.678 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 8.615497e-02 | 1.065 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.345062e-01 | 0.630 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.055396e-01 | 0.977 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.464520e-01 | 0.608 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.582122e-01 | 0.588 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 2.582122e-01 | 0.588 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.582122e-01 | 0.588 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.697895e-01 | 0.569 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.697895e-01 | 0.569 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 7.246093e-02 | 1.140 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 7.246093e-02 | 1.140 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.364940e-01 | 0.865 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.691336e-01 | 0.772 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.088069e-01 | 0.963 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.256705e-01 | 0.901 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.431269e-01 | 0.614 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.849864e-01 | 0.733 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.849864e-01 | 0.733 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.778585e-01 | 0.556 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.251488e-01 | 0.648 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.656902e-01 | 0.781 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.280998e-01 | 0.642 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.100457e-01 | 0.678 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.541870e-01 | 0.595 |
| R-HSA-157579 | Telomere Maintenance | 9.205973e-02 | 1.036 |
| R-HSA-73893 | DNA Damage Bypass | 2.258206e-01 | 0.646 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.333819e-01 | 0.632 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 8.149556e-02 | 1.089 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.625836e-01 | 0.581 |
| R-HSA-180786 | Extension of Telomeres | 8.985577e-02 | 1.046 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.746974e-01 | 0.758 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.746974e-01 | 0.758 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.582122e-01 | 0.588 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.029076e-01 | 0.693 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.810797e-01 | 0.742 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.100457e-01 | 0.678 |
| R-HSA-73886 | Chromosome Maintenance | 1.646422e-01 | 0.783 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.718878e-01 | 0.765 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.464520e-01 | 0.608 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.582122e-01 | 0.588 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.364940e-01 | 0.865 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.291507e-01 | 0.889 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.434033e-01 | 0.843 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.691336e-01 | 0.772 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.312017e-01 | 0.882 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.142287e-01 | 0.942 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.259588e-01 | 0.900 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.697895e-01 | 0.569 |
| R-HSA-9664420 | Killing mechanisms | 2.697895e-01 | 0.569 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.526397e-01 | 0.816 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.802902e-01 | 0.744 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.101209e-01 | 0.958 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.771960e-01 | 0.752 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 7.807660e-02 | 1.107 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.041689e-01 | 0.982 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.848068e-01 | 0.733 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.154417e-01 | 0.938 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.318943e-01 | 0.880 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.223718e-01 | 0.653 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 2.464520e-01 | 0.608 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 8.095397e-02 | 1.092 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 1.041689e-01 | 0.982 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.587648e-01 | 0.799 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.587648e-01 | 0.799 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.848068e-01 | 0.733 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 7.691801e-02 | 1.114 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.100457e-01 | 0.678 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.223718e-01 | 0.653 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.345062e-01 | 0.630 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.105555e-01 | 0.956 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.156327e-01 | 0.937 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.472157e-01 | 0.832 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.086131e-01 | 0.681 |
| R-HSA-73894 | DNA Repair | 7.944323e-02 | 1.100 |
| R-HSA-2424491 | DAP12 signaling | 1.105555e-01 | 0.956 |
| R-HSA-170968 | Frs2-mediated activation | 2.345062e-01 | 0.630 |
| R-HSA-72312 | rRNA processing | 2.072578e-01 | 0.683 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.718878e-01 | 0.765 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.582122e-01 | 0.588 |
| R-HSA-169893 | Prolonged ERK activation events | 2.697895e-01 | 0.569 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.454347e-01 | 0.837 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.454347e-01 | 0.837 |
| R-HSA-198203 | PI3K/AKT activation | 1.848068e-01 | 0.733 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.464520e-01 | 0.608 |
| R-HSA-1502540 | Signaling by Activin | 2.582122e-01 | 0.588 |
| R-HSA-9907900 | Proteasome assembly | 1.972206e-01 | 0.705 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 9.539061e-02 | 1.020 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 8.149556e-02 | 1.089 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 9.089257e-02 | 1.041 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.023269e-01 | 0.990 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.691336e-01 | 0.772 |
| R-HSA-5260271 | Diseases of Immune System | 1.691336e-01 | 0.772 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.291507e-01 | 0.889 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.291507e-01 | 0.889 |
| R-HSA-205025 | NADE modulates death signalling | 8.997728e-02 | 1.046 |
| R-HSA-9729555 | Sensory perception of sour taste | 8.997728e-02 | 1.046 |
| R-HSA-9734207 | Nucleotide salvage defects | 1.587648e-01 | 0.799 |
| R-HSA-170984 | ARMS-mediated activation | 1.718878e-01 | 0.765 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 2.100457e-01 | 0.678 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 2.345062e-01 | 0.630 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.207681e-01 | 0.918 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.582122e-01 | 0.588 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.582122e-01 | 0.588 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.418330e-01 | 0.848 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.418330e-01 | 0.848 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 9.600779e-02 | 1.018 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.802902e-01 | 0.744 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.802902e-01 | 0.744 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.143350e-01 | 0.669 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.489097e-01 | 0.604 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.137901e-01 | 0.670 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.200714e-01 | 0.657 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 2.582122e-01 | 0.588 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 2.582122e-01 | 0.588 |
| R-HSA-195721 | Signaling by WNT | 2.357880e-01 | 0.627 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 1.156327e-01 | 0.937 |
| R-HSA-5689603 | UCH proteinases | 1.470454e-01 | 0.833 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.226005e-01 | 0.652 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.318943e-01 | 0.880 |
| R-HSA-389542 | NADPH regeneration | 1.318943e-01 | 0.880 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.454347e-01 | 0.837 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.454347e-01 | 0.837 |
| R-HSA-446205 | Synthesis of GDP-mannose | 2.223718e-01 | 0.653 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 2.345062e-01 | 0.630 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.582122e-01 | 0.588 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.582122e-01 | 0.588 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.472157e-01 | 0.832 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.472157e-01 | 0.832 |
| R-HSA-4641257 | Degradation of AXIN | 1.526397e-01 | 0.816 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.526397e-01 | 0.816 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.636012e-01 | 0.786 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.431269e-01 | 0.614 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.546968e-01 | 0.594 |
| R-HSA-2172127 | DAP12 interactions | 1.972206e-01 | 0.705 |
| R-HSA-9758941 | Gastrulation | 1.249328e-01 | 0.903 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.055471e-01 | 0.977 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.802902e-01 | 0.744 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.928170e-01 | 0.715 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.838760e-01 | 0.735 |
| R-HSA-196780 | Biotin transport and metabolism | 2.582122e-01 | 0.588 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 9.089257e-02 | 1.041 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.312017e-01 | 0.882 |
| R-HSA-112399 | IRS-mediated signalling | 2.720690e-01 | 0.565 |
| R-HSA-112043 | PLC beta mediated events | 9.600779e-02 | 1.018 |
| R-HSA-1227986 | Signaling by ERBB2 | 9.291052e-02 | 1.032 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.364940e-01 | 0.865 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 9.914681e-02 | 1.004 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.627021e-01 | 0.581 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.088069e-01 | 0.963 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.718878e-01 | 0.765 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 1.975251e-01 | 0.704 |
| R-HSA-8874081 | MET activates PTK2 signaling | 9.089257e-02 | 1.041 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 2.345062e-01 | 0.630 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.464520e-01 | 0.608 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.312017e-01 | 0.882 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.697895e-01 | 0.569 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.364940e-01 | 0.865 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.364940e-01 | 0.865 |
| R-HSA-169911 | Regulation of Apoptosis | 1.418330e-01 | 0.848 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.802902e-01 | 0.744 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.802902e-01 | 0.744 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.315807e-01 | 0.635 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.431269e-01 | 0.614 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.849864e-01 | 0.733 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.710150e-01 | 0.567 |
| R-HSA-2559583 | Cellular Senescence | 2.054784e-01 | 0.687 |
| R-HSA-69242 | S Phase | 2.653129e-01 | 0.576 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.619060e-01 | 0.791 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.247705e-01 | 0.904 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.434033e-01 | 0.843 |
| R-HSA-1474165 | Reproduction | 8.212885e-02 | 1.086 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.008273e-01 | 0.697 |
| R-HSA-5578775 | Ion homeostasis | 8.095397e-02 | 1.092 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.055471e-01 | 0.977 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.091126e-01 | 0.962 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.684269e-01 | 0.571 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.625836e-01 | 0.581 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.418330e-01 | 0.848 |
| R-HSA-112040 | G-protein mediated events | 1.154417e-01 | 0.938 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.718878e-01 | 0.765 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.746974e-01 | 0.758 |
| R-HSA-109704 | PI3K Cascade | 2.315807e-01 | 0.635 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.848068e-01 | 0.733 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.716008e-01 | 0.566 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.810797e-01 | 0.742 |
| R-HSA-1280218 | Adaptive Immune System | 7.823815e-02 | 1.107 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.397920e-01 | 0.855 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.791227e-01 | 0.554 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.385018e-01 | 0.859 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.587648e-01 | 0.799 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.718878e-01 | 0.765 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 9.089257e-02 | 1.041 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.636012e-01 | 0.786 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.636012e-01 | 0.786 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.915540e-01 | 0.718 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.972206e-01 | 0.705 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.194488e-01 | 0.923 |
| R-HSA-8953854 | Metabolism of RNA | 2.733391e-01 | 0.563 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.194488e-01 | 0.923 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.603919e-01 | 0.795 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.464520e-01 | 0.608 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.394089e-01 | 0.856 |
| R-HSA-8982491 | Glycogen metabolism | 1.691336e-01 | 0.772 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.210540e-01 | 0.656 |
| R-HSA-70171 | Glycolysis | 2.541870e-01 | 0.595 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.915540e-01 | 0.718 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.223718e-01 | 0.653 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.345062e-01 | 0.630 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.029076e-01 | 0.693 |
| R-HSA-70326 | Glucose metabolism | 1.528099e-01 | 0.816 |
| R-HSA-202424 | Downstream TCR signaling | 2.048373e-01 | 0.689 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.865290e-01 | 0.729 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.023269e-01 | 0.990 |
| R-HSA-111885 | Opioid Signalling | 2.710150e-01 | 0.567 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.223718e-01 | 0.653 |
| R-HSA-70263 | Gluconeogenesis | 2.200714e-01 | 0.657 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.105555e-01 | 0.956 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.198029e-01 | 0.922 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.223718e-01 | 0.653 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.697895e-01 | 0.569 |
| R-HSA-5635838 | Activation of SMO | 2.697895e-01 | 0.569 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.691336e-01 | 0.772 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.746974e-01 | 0.758 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.029076e-01 | 0.693 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.143350e-01 | 0.669 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.375189e-01 | 0.624 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.008706e-01 | 0.697 |
| R-HSA-5688426 | Deubiquitination | 2.657867e-01 | 0.575 |
| R-HSA-9842663 | Signaling by LTK | 2.223718e-01 | 0.653 |
| R-HSA-177929 | Signaling by EGFR | 8.095397e-02 | 1.092 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.143350e-01 | 0.669 |
| R-HSA-9766229 | Degradation of CDH1 | 2.258206e-01 | 0.646 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.373500e-01 | 0.625 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.581486e-01 | 0.801 |
| R-HSA-1643685 | Disease | 7.933752e-02 | 1.101 |
| R-HSA-9931953 | Biofilm formation | 1.581024e-01 | 0.801 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.029076e-01 | 0.693 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.029076e-01 | 0.693 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.169748e-01 | 0.664 |
| R-HSA-446728 | Cell junction organization | 1.912695e-01 | 0.718 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.416686e-01 | 0.617 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.691336e-01 | 0.772 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.697895e-01 | 0.569 |
| R-HSA-8875878 | MET promotes cell motility | 1.581024e-01 | 0.801 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.373500e-01 | 0.625 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.722024e-01 | 0.565 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.291507e-01 | 0.889 |
| R-HSA-1500931 | Cell-Cell communication | 1.619818e-01 | 0.791 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.582122e-01 | 0.588 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.489097e-01 | 0.604 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.105555e-01 | 0.956 |
| R-HSA-69541 | Stabilization of p53 | 1.636012e-01 | 0.786 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.373500e-01 | 0.625 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.720690e-01 | 0.565 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.507540e-01 | 0.822 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.500033e-01 | 0.602 |
| R-HSA-6806834 | Signaling by MET | 1.619060e-01 | 0.791 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.169748e-01 | 0.664 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.207681e-01 | 0.918 |
| R-HSA-9824272 | Somitogenesis | 2.029076e-01 | 0.693 |
| R-HSA-5663205 | Infectious disease | 1.279187e-01 | 0.893 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 9.570484e-02 | 1.019 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.275438e-02 | 1.033 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.258206e-01 | 0.646 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.258206e-01 | 0.646 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.756589e-01 | 0.560 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.422914e-02 | 1.075 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.854777e-02 | 1.006 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.364940e-01 | 0.865 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.431269e-01 | 0.614 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.791227e-01 | 0.554 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.629612e-01 | 0.788 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.811869e-01 | 0.551 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.811869e-01 | 0.551 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.811869e-01 | 0.551 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.811869e-01 | 0.551 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.811869e-01 | 0.551 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.811869e-01 | 0.551 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.811869e-01 | 0.551 |
| R-HSA-70370 | Galactose catabolism | 2.811869e-01 | 0.551 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.825936e-01 | 0.549 |
| R-HSA-69306 | DNA Replication | 2.825936e-01 | 0.549 |
| R-HSA-109582 | Hemostasis | 2.859510e-01 | 0.544 |
| R-HSA-69239 | Synthesis of DNA | 2.879619e-01 | 0.541 |
| R-HSA-351202 | Metabolism of polyamines | 2.894276e-01 | 0.538 |
| R-HSA-379724 | tRNA Aminoacylation | 2.894276e-01 | 0.538 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.922125e-01 | 0.534 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.924070e-01 | 0.534 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.924070e-01 | 0.534 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.924070e-01 | 0.534 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.924070e-01 | 0.534 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.924070e-01 | 0.534 |
| R-HSA-3229121 | Glycogen storage diseases | 2.924070e-01 | 0.534 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.952046e-01 | 0.530 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.952046e-01 | 0.530 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.955843e-01 | 0.529 |
| R-HSA-9679506 | SARS-CoV Infections | 2.978306e-01 | 0.526 |
| R-HSA-202403 | TCR signaling | 3.007262e-01 | 0.522 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.009748e-01 | 0.521 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.009748e-01 | 0.521 |
| R-HSA-186797 | Signaling by PDGF | 3.009748e-01 | 0.521 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.034527e-01 | 0.518 |
| R-HSA-163615 | PKA activation | 3.034527e-01 | 0.518 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.034527e-01 | 0.518 |
| R-HSA-164378 | PKA activation in glucagon signalling | 3.034527e-01 | 0.518 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.034527e-01 | 0.518 |
| R-HSA-3928664 | Ephrin signaling | 3.034527e-01 | 0.518 |
| R-HSA-180292 | GAB1 signalosome | 3.034527e-01 | 0.518 |
| R-HSA-5358508 | Mismatch Repair | 3.034527e-01 | 0.518 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.034527e-01 | 0.518 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.034527e-01 | 0.518 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 3.034527e-01 | 0.518 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.034527e-01 | 0.518 |
| R-HSA-210993 | Tie2 Signaling | 3.034527e-01 | 0.518 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.067372e-01 | 0.513 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.092527e-01 | 0.510 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.124905e-01 | 0.505 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.143266e-01 | 0.503 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.143266e-01 | 0.503 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.143266e-01 | 0.503 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 3.143266e-01 | 0.503 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.143266e-01 | 0.503 |
| R-HSA-9834899 | Specification of the neural plate border | 3.143266e-01 | 0.503 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.143266e-01 | 0.503 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.177874e-01 | 0.498 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.182337e-01 | 0.497 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.182337e-01 | 0.497 |
| R-HSA-449147 | Signaling by Interleukins | 3.183077e-01 | 0.497 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.239656e-01 | 0.490 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 3.239656e-01 | 0.490 |
| R-HSA-9823730 | Formation of definitive endoderm | 3.250314e-01 | 0.488 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.250314e-01 | 0.488 |
| R-HSA-1181150 | Signaling by NODAL | 3.250314e-01 | 0.488 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 3.250314e-01 | 0.488 |
| R-HSA-196108 | Pregnenolone biosynthesis | 3.250314e-01 | 0.488 |
| R-HSA-373753 | Nephrin family interactions | 3.250314e-01 | 0.488 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.305955e-01 | 0.481 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.348642e-01 | 0.475 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.348642e-01 | 0.475 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.355698e-01 | 0.474 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.355698e-01 | 0.474 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.355698e-01 | 0.474 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.355698e-01 | 0.474 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.355698e-01 | 0.474 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 3.355698e-01 | 0.474 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.355698e-01 | 0.474 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.355698e-01 | 0.474 |
| R-HSA-6798695 | Neutrophil degranulation | 3.383775e-01 | 0.471 |
| R-HSA-5693538 | Homology Directed Repair | 3.433979e-01 | 0.464 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.433979e-01 | 0.464 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.458801e-01 | 0.461 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.459443e-01 | 0.461 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.459443e-01 | 0.461 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.459443e-01 | 0.461 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.459443e-01 | 0.461 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.459443e-01 | 0.461 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.459443e-01 | 0.461 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.459443e-01 | 0.461 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.459443e-01 | 0.461 |
| R-HSA-9755088 | Ribavirin ADME | 3.459443e-01 | 0.461 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.467606e-01 | 0.460 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.467606e-01 | 0.460 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.467606e-01 | 0.460 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.467606e-01 | 0.460 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.467606e-01 | 0.460 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.476618e-01 | 0.459 |
| R-HSA-68875 | Mitotic Prophase | 3.519230e-01 | 0.454 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 3.524214e-01 | 0.453 |
| R-HSA-3000178 | ECM proteoglycans | 3.524214e-01 | 0.453 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.561574e-01 | 0.448 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.561574e-01 | 0.448 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.561574e-01 | 0.448 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.561574e-01 | 0.448 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.561574e-01 | 0.448 |
| R-HSA-8964038 | LDL clearance | 3.561574e-01 | 0.448 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.561574e-01 | 0.448 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.580651e-01 | 0.446 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.580651e-01 | 0.446 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.583282e-01 | 0.446 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.600435e-01 | 0.444 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.608219e-01 | 0.443 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.636911e-01 | 0.439 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.636911e-01 | 0.439 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 3.636911e-01 | 0.439 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.646862e-01 | 0.438 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.646862e-01 | 0.438 |
| R-HSA-200425 | Carnitine shuttle | 3.662116e-01 | 0.436 |
| R-HSA-3000170 | Syndecan interactions | 3.662116e-01 | 0.436 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.692984e-01 | 0.433 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.750105e-01 | 0.426 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.761095e-01 | 0.425 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.761095e-01 | 0.425 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.761095e-01 | 0.425 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.774090e-01 | 0.423 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.774090e-01 | 0.423 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.774090e-01 | 0.423 |
| R-HSA-194138 | Signaling by VEGF | 3.774090e-01 | 0.423 |
| R-HSA-69206 | G1/S Transition | 3.774090e-01 | 0.423 |
| R-HSA-168255 | Influenza Infection | 3.777373e-01 | 0.423 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.777939e-01 | 0.423 |
| R-HSA-8939211 | ESR-mediated signaling | 3.786067e-01 | 0.422 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.804540e-01 | 0.420 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.804540e-01 | 0.420 |
| R-HSA-3214842 | HDMs demethylate histones | 3.858533e-01 | 0.414 |
| R-HSA-9620244 | Long-term potentiation | 3.858533e-01 | 0.414 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.858533e-01 | 0.414 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 3.858533e-01 | 0.414 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.858533e-01 | 0.414 |
| R-HSA-420029 | Tight junction interactions | 3.858533e-01 | 0.414 |
| R-HSA-2160916 | Hyaluronan degradation | 3.858533e-01 | 0.414 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.858533e-01 | 0.414 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.858533e-01 | 0.414 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 3.860007e-01 | 0.413 |
| R-HSA-157118 | Signaling by NOTCH | 3.878864e-01 | 0.411 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.900793e-01 | 0.409 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.915259e-01 | 0.407 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.915259e-01 | 0.407 |
| R-HSA-5619084 | ABC transporter disorders | 3.915259e-01 | 0.407 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.954456e-01 | 0.403 |
| R-HSA-70635 | Urea cycle | 3.954456e-01 | 0.403 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.954456e-01 | 0.403 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.954456e-01 | 0.403 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.954456e-01 | 0.403 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.965263e-01 | 0.402 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.984916e-01 | 0.400 |
| R-HSA-597592 | Post-translational protein modification | 4.001797e-01 | 0.398 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.025087e-01 | 0.395 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.048887e-01 | 0.393 |
| R-HSA-171306 | Packaging Of Telomere Ends | 4.048887e-01 | 0.393 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.048887e-01 | 0.393 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.048887e-01 | 0.393 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.048887e-01 | 0.393 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.048887e-01 | 0.393 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 4.048887e-01 | 0.393 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.048887e-01 | 0.393 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.048887e-01 | 0.393 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 4.048887e-01 | 0.393 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.048887e-01 | 0.393 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.048887e-01 | 0.393 |
| R-HSA-5576891 | Cardiac conduction | 4.068724e-01 | 0.391 |
| R-HSA-977225 | Amyloid fiber formation | 4.079650e-01 | 0.389 |
| R-HSA-9909396 | Circadian clock | 4.110501e-01 | 0.386 |
| R-HSA-983712 | Ion channel transport | 4.129586e-01 | 0.384 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.141848e-01 | 0.383 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.141848e-01 | 0.383 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.141848e-01 | 0.383 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.141848e-01 | 0.383 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.141848e-01 | 0.383 |
| R-HSA-77387 | Insulin receptor recycling | 4.141848e-01 | 0.383 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.188047e-01 | 0.378 |
| R-HSA-5334118 | DNA methylation | 4.233363e-01 | 0.373 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.233363e-01 | 0.373 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.233363e-01 | 0.373 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.233363e-01 | 0.373 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.233363e-01 | 0.373 |
| R-HSA-180024 | DARPP-32 events | 4.233363e-01 | 0.373 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.233363e-01 | 0.373 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.233363e-01 | 0.373 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.317963e-01 | 0.365 |
| R-HSA-163685 | Integration of energy metabolism | 4.317963e-01 | 0.365 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.323454e-01 | 0.364 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.323454e-01 | 0.364 |
| R-HSA-2206281 | Mucopolysaccharidoses | 4.323454e-01 | 0.364 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.323454e-01 | 0.364 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.323454e-01 | 0.364 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.401766e-01 | 0.356 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.412142e-01 | 0.355 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.412142e-01 | 0.355 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.412142e-01 | 0.355 |
| R-HSA-186763 | Downstream signal transduction | 4.412142e-01 | 0.355 |
| R-HSA-182971 | EGFR downregulation | 4.412142e-01 | 0.355 |
| R-HSA-6807070 | PTEN Regulation | 4.441181e-01 | 0.353 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.454526e-01 | 0.351 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.499451e-01 | 0.347 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.499451e-01 | 0.347 |
| R-HSA-69190 | DNA strand elongation | 4.499451e-01 | 0.347 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.499451e-01 | 0.347 |
| R-HSA-156902 | Peptide chain elongation | 4.507009e-01 | 0.346 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.507009e-01 | 0.346 |
| R-HSA-168256 | Immune System | 4.520364e-01 | 0.345 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.585400e-01 | 0.339 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.585400e-01 | 0.339 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.585400e-01 | 0.339 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.585400e-01 | 0.339 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.585400e-01 | 0.339 |
| R-HSA-159418 | Recycling of bile acids and salts | 4.585400e-01 | 0.339 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.585400e-01 | 0.339 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.585400e-01 | 0.339 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.585400e-01 | 0.339 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 4.585400e-01 | 0.339 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.585400e-01 | 0.339 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.611128e-01 | 0.336 |
| R-HSA-73884 | Base Excision Repair | 4.611128e-01 | 0.336 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.644168e-01 | 0.333 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.662755e-01 | 0.331 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 4.662755e-01 | 0.331 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.670012e-01 | 0.331 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.670012e-01 | 0.331 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 4.670012e-01 | 0.331 |
| R-HSA-2024101 | CS/DS degradation | 4.670012e-01 | 0.331 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.670012e-01 | 0.331 |
| R-HSA-189483 | Heme degradation | 4.670012e-01 | 0.331 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.714090e-01 | 0.327 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.735061e-01 | 0.325 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 4.753307e-01 | 0.323 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.753307e-01 | 0.323 |
| R-HSA-2142845 | Hyaluronan metabolism | 4.753307e-01 | 0.323 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.753307e-01 | 0.323 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.753307e-01 | 0.323 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.764408e-01 | 0.322 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.765129e-01 | 0.322 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.835305e-01 | 0.316 |
| R-HSA-187687 | Signalling to ERKs | 4.835305e-01 | 0.316 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 4.835305e-01 | 0.316 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.835305e-01 | 0.316 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 4.835305e-01 | 0.316 |
| R-HSA-166520 | Signaling by NTRKs | 4.843877e-01 | 0.315 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.916027e-01 | 0.308 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.916027e-01 | 0.308 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.916027e-01 | 0.308 |
| R-HSA-163560 | Triglyceride catabolism | 4.916027e-01 | 0.308 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.916027e-01 | 0.308 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.916438e-01 | 0.308 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.966262e-01 | 0.304 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.966262e-01 | 0.304 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.995492e-01 | 0.301 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.995492e-01 | 0.301 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.995492e-01 | 0.301 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.995492e-01 | 0.301 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.015775e-01 | 0.300 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.015775e-01 | 0.300 |
| R-HSA-73927 | Depurination | 5.073719e-01 | 0.295 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.073719e-01 | 0.295 |
| R-HSA-74217 | Purine salvage | 5.073719e-01 | 0.295 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.073719e-01 | 0.295 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.078752e-01 | 0.294 |
| R-HSA-73887 | Death Receptor Signaling | 5.078752e-01 | 0.294 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.113859e-01 | 0.291 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.150729e-01 | 0.288 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 5.150729e-01 | 0.288 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.150729e-01 | 0.288 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.150729e-01 | 0.288 |
| R-HSA-201556 | Signaling by ALK | 5.150729e-01 | 0.288 |
| R-HSA-3214847 | HATs acetylate histones | 5.162425e-01 | 0.287 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.210672e-01 | 0.283 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.226539e-01 | 0.282 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.226539e-01 | 0.282 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.226539e-01 | 0.282 |
| R-HSA-167169 | HIV Transcription Elongation | 5.226539e-01 | 0.282 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.226539e-01 | 0.282 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 5.226539e-01 | 0.282 |
| R-HSA-9711097 | Cellular response to starvation | 5.232220e-01 | 0.281 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.232220e-01 | 0.281 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.258598e-01 | 0.279 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.258598e-01 | 0.279 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.258598e-01 | 0.279 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.301169e-01 | 0.276 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.301169e-01 | 0.276 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.301169e-01 | 0.276 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 5.301169e-01 | 0.276 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.301169e-01 | 0.276 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.301169e-01 | 0.276 |
| R-HSA-1483255 | PI Metabolism | 5.306200e-01 | 0.275 |
| R-HSA-192823 | Viral mRNA Translation | 5.353477e-01 | 0.271 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.374637e-01 | 0.270 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 5.374637e-01 | 0.270 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.400429e-01 | 0.268 |
| R-HSA-162906 | HIV Infection | 5.442524e-01 | 0.264 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.446960e-01 | 0.264 |
| R-HSA-165159 | MTOR signalling | 5.446960e-01 | 0.264 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.446960e-01 | 0.264 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.446960e-01 | 0.264 |
| R-HSA-73928 | Depyrimidination | 5.446960e-01 | 0.264 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.446960e-01 | 0.264 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.447052e-01 | 0.264 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.447052e-01 | 0.264 |
| R-HSA-9710421 | Defective pyroptosis | 5.518157e-01 | 0.258 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.518157e-01 | 0.258 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.518157e-01 | 0.258 |
| R-HSA-8854214 | TBC/RABGAPs | 5.518157e-01 | 0.258 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.584944e-01 | 0.253 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.588245e-01 | 0.253 |
| R-HSA-373752 | Netrin-1 signaling | 5.588245e-01 | 0.253 |
| R-HSA-72766 | Translation | 5.629231e-01 | 0.250 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.630246e-01 | 0.249 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.630246e-01 | 0.249 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.630246e-01 | 0.249 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.657241e-01 | 0.247 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.657241e-01 | 0.247 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.657241e-01 | 0.247 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.725163e-01 | 0.242 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.725163e-01 | 0.242 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.725163e-01 | 0.242 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.725163e-01 | 0.242 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.747933e-01 | 0.240 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.808119e-01 | 0.236 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.808119e-01 | 0.236 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.818733e-01 | 0.235 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.818733e-01 | 0.235 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 5.851752e-01 | 0.233 |
| R-HSA-9634597 | GPER1 signaling | 5.857847e-01 | 0.232 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.857847e-01 | 0.232 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.938011e-01 | 0.226 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 5.986429e-01 | 0.223 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.022929e-01 | 0.220 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.055113e-01 | 0.218 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.106506e-01 | 0.214 |
| R-HSA-72187 | mRNA 3'-end processing | 6.111035e-01 | 0.214 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.111035e-01 | 0.214 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.111035e-01 | 0.214 |
| R-HSA-421270 | Cell-cell junction organization | 6.171511e-01 | 0.210 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.171885e-01 | 0.210 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.171885e-01 | 0.210 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.171885e-01 | 0.210 |
| R-HSA-1221632 | Meiotic synapsis | 6.171885e-01 | 0.210 |
| R-HSA-8956320 | Nucleotide biosynthesis | 6.171885e-01 | 0.210 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.219664e-01 | 0.206 |
| R-HSA-72649 | Translation initiation complex formation | 6.231787e-01 | 0.205 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.231787e-01 | 0.205 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.231787e-01 | 0.205 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.269642e-01 | 0.203 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.290755e-01 | 0.201 |
| R-HSA-418597 | G alpha (z) signalling events | 6.290755e-01 | 0.201 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 6.290755e-01 | 0.201 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.348804e-01 | 0.197 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.348804e-01 | 0.197 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.348804e-01 | 0.197 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.348804e-01 | 0.197 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.348804e-01 | 0.197 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.388493e-01 | 0.195 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.405948e-01 | 0.193 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.462202e-01 | 0.190 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.462202e-01 | 0.190 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.517578e-01 | 0.186 |
| R-HSA-4085001 | Sialic acid metabolism | 6.517578e-01 | 0.186 |
| R-HSA-8979227 | Triglyceride metabolism | 6.517578e-01 | 0.186 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.517578e-01 | 0.186 |
| R-HSA-416476 | G alpha (q) signalling events | 6.534800e-01 | 0.185 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.572091e-01 | 0.182 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.572091e-01 | 0.182 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.572091e-01 | 0.182 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.572091e-01 | 0.182 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.577886e-01 | 0.182 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.625753e-01 | 0.179 |
| R-HSA-211976 | Endogenous sterols | 6.625753e-01 | 0.179 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.625753e-01 | 0.179 |
| R-HSA-8956321 | Nucleotide salvage | 6.625753e-01 | 0.179 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.678579e-01 | 0.175 |
| R-HSA-9707616 | Heme signaling | 6.678579e-01 | 0.175 |
| R-HSA-9843745 | Adipogenesis | 6.727233e-01 | 0.172 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 6.727233e-01 | 0.172 |
| R-HSA-373755 | Semaphorin interactions | 6.730581e-01 | 0.172 |
| R-HSA-392499 | Metabolism of proteins | 6.751752e-01 | 0.171 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.763242e-01 | 0.170 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.798212e-01 | 0.168 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.930605e-01 | 0.159 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.930605e-01 | 0.159 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.930605e-01 | 0.159 |
| R-HSA-196071 | Metabolism of steroid hormones | 6.930605e-01 | 0.159 |
| R-HSA-9658195 | Leishmania infection | 6.974155e-01 | 0.157 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.974155e-01 | 0.157 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.978676e-01 | 0.156 |
| R-HSA-167172 | Transcription of the HIV genome | 6.978676e-01 | 0.156 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.998720e-01 | 0.155 |
| R-HSA-397014 | Muscle contraction | 7.072176e-01 | 0.150 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.072580e-01 | 0.150 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.072580e-01 | 0.150 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.073000e-01 | 0.150 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.073000e-01 | 0.150 |
| R-HSA-9664407 | Parasite infection | 7.073000e-01 | 0.150 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.105852e-01 | 0.148 |
| R-HSA-8978934 | Metabolism of cofactors | 7.118436e-01 | 0.148 |
| R-HSA-189445 | Metabolism of porphyrins | 7.118436e-01 | 0.148 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.163577e-01 | 0.145 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 7.163577e-01 | 0.145 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.170634e-01 | 0.144 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.208013e-01 | 0.142 |
| R-HSA-4086398 | Ca2+ pathway | 7.208013e-01 | 0.142 |
| R-HSA-418990 | Adherens junctions interactions | 7.233089e-01 | 0.141 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.234197e-01 | 0.141 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.251756e-01 | 0.140 |
| R-HSA-8852135 | Protein ubiquitination | 7.294816e-01 | 0.137 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.294816e-01 | 0.137 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.294816e-01 | 0.137 |
| R-HSA-8951664 | Neddylation | 7.310935e-01 | 0.136 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.357721e-01 | 0.133 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.420005e-01 | 0.130 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 7.420005e-01 | 0.130 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.500242e-01 | 0.125 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.539423e-01 | 0.123 |
| R-HSA-1989781 | PPARA activates gene expression | 7.562616e-01 | 0.121 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.562616e-01 | 0.121 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.577993e-01 | 0.120 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.577993e-01 | 0.120 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.615960e-01 | 0.118 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.618592e-01 | 0.118 |
| R-HSA-162587 | HIV Life Cycle | 7.618592e-01 | 0.118 |
| R-HSA-9610379 | HCMV Late Events | 7.618592e-01 | 0.118 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 7.618592e-01 | 0.118 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.622872e-01 | 0.118 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.628552e-01 | 0.118 |
| R-HSA-877300 | Interferon gamma signaling | 7.673455e-01 | 0.115 |
| R-HSA-15869 | Metabolism of nucleotides | 7.674628e-01 | 0.115 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.726342e-01 | 0.112 |
| R-HSA-70268 | Pyruvate metabolism | 7.797086e-01 | 0.108 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.805841e-01 | 0.108 |
| R-HSA-5619102 | SLC transporter disorders | 7.882076e-01 | 0.103 |
| R-HSA-8957322 | Metabolism of steroids | 7.903312e-01 | 0.102 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.932065e-01 | 0.101 |
| R-HSA-4839726 | Chromatin organization | 7.956649e-01 | 0.099 |
| R-HSA-72306 | tRNA processing | 7.980103e-01 | 0.098 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.996432e-01 | 0.097 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.027863e-01 | 0.095 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.058803e-01 | 0.094 |
| R-HSA-1474290 | Collagen formation | 8.058803e-01 | 0.094 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.089260e-01 | 0.092 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.177803e-01 | 0.087 |
| R-HSA-190236 | Signaling by FGFR | 8.206400e-01 | 0.086 |
| R-HSA-422356 | Regulation of insulin secretion | 8.206400e-01 | 0.086 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.234550e-01 | 0.084 |
| R-HSA-5668914 | Diseases of metabolism | 8.343389e-01 | 0.079 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 8.419651e-01 | 0.075 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.431596e-01 | 0.074 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.450634e-01 | 0.073 |
| R-HSA-211000 | Gene Silencing by RNA | 8.468893e-01 | 0.072 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.492938e-01 | 0.071 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.492938e-01 | 0.071 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.516607e-01 | 0.070 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.539905e-01 | 0.069 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.539905e-01 | 0.069 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.539905e-01 | 0.069 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.607636e-01 | 0.065 |
| R-HSA-9640148 | Infection with Enterobacteria | 8.646637e-01 | 0.063 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.672237e-01 | 0.062 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.693100e-01 | 0.061 |
| R-HSA-1592230 | Mitochondrial biogenesis | 8.733851e-01 | 0.059 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.773337e-01 | 0.057 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.773337e-01 | 0.057 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.830278e-01 | 0.054 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.830278e-01 | 0.054 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.919388e-01 | 0.050 |
| R-HSA-9717189 | Sensory perception of taste | 9.017437e-01 | 0.045 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.047506e-01 | 0.043 |
| R-HSA-168249 | Innate Immune System | 9.068674e-01 | 0.042 |
| R-HSA-1474244 | Extracellular matrix organization | 9.148789e-01 | 0.039 |
| R-HSA-382551 | Transport of small molecules | 9.201734e-01 | 0.036 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.399269e-01 | 0.027 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.415933e-01 | 0.026 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.462508e-01 | 0.024 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.495270e-01 | 0.022 |
| R-HSA-418555 | G alpha (s) signalling events | 9.503575e-01 | 0.022 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.519113e-01 | 0.021 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.519113e-01 | 0.021 |
| R-HSA-1483257 | Phospholipid metabolism | 9.591736e-01 | 0.018 |
| R-HSA-3781865 | Diseases of glycosylation | 9.596305e-01 | 0.018 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.608451e-01 | 0.017 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.608950e-01 | 0.017 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.650182e-01 | 0.015 |
| R-HSA-418594 | G alpha (i) signalling events | 9.652623e-01 | 0.015 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.655708e-01 | 0.015 |
| R-HSA-372790 | Signaling by GPCR | 9.681562e-01 | 0.014 |
| R-HSA-388396 | GPCR downstream signalling | 9.683990e-01 | 0.014 |
| R-HSA-428157 | Sphingolipid metabolism | 9.692027e-01 | 0.014 |
| R-HSA-72172 | mRNA Splicing | 9.711040e-01 | 0.013 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.736803e-01 | 0.012 |
| R-HSA-9748784 | Drug ADME | 9.768836e-01 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.780534e-01 | 0.010 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.806040e-01 | 0.009 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.829292e-01 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.889969e-01 | 0.005 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.911368e-01 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 9.913271e-01 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.986474e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.996815e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.998325e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999429e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999879e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999989e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.875 | 0.116 | 2 | 0.872 |
PRPK |
0.862 | -0.073 | -1 | 0.852 |
MOS |
0.862 | 0.104 | 1 | 0.915 |
CLK3 |
0.860 | 0.104 | 1 | 0.871 |
CDC7 |
0.860 | -0.009 | 1 | 0.894 |
GCN2 |
0.859 | -0.121 | 2 | 0.819 |
PIM3 |
0.857 | -0.007 | -3 | 0.784 |
CAMK1B |
0.857 | -0.003 | -3 | 0.806 |
ULK2 |
0.857 | -0.098 | 2 | 0.837 |
DSTYK |
0.856 | -0.025 | 2 | 0.869 |
ERK5 |
0.855 | 0.067 | 1 | 0.841 |
NLK |
0.855 | 0.017 | 1 | 0.847 |
BMPR2 |
0.855 | -0.092 | -2 | 0.887 |
IKKB |
0.855 | -0.113 | -2 | 0.771 |
TBK1 |
0.854 | -0.103 | 1 | 0.744 |
PKN3 |
0.854 | 0.028 | -3 | 0.767 |
PRKD1 |
0.854 | 0.058 | -3 | 0.756 |
KIS |
0.853 | 0.072 | 1 | 0.711 |
NEK6 |
0.853 | -0.024 | -2 | 0.863 |
RAF1 |
0.852 | -0.156 | 1 | 0.852 |
CAMK2G |
0.852 | -0.067 | 2 | 0.795 |
CHAK2 |
0.852 | 0.046 | -1 | 0.824 |
ATR |
0.852 | -0.007 | 1 | 0.869 |
NUAK2 |
0.852 | 0.024 | -3 | 0.789 |
NDR2 |
0.851 | -0.057 | -3 | 0.796 |
CDKL1 |
0.850 | -0.023 | -3 | 0.732 |
PDHK4 |
0.850 | -0.317 | 1 | 0.870 |
TGFBR2 |
0.850 | -0.031 | -2 | 0.804 |
TSSK2 |
0.850 | 0.077 | -5 | 0.827 |
MTOR |
0.849 | -0.197 | 1 | 0.816 |
GRK1 |
0.849 | 0.075 | -2 | 0.789 |
NIK |
0.848 | -0.055 | -3 | 0.832 |
NEK7 |
0.848 | -0.118 | -3 | 0.774 |
GRK5 |
0.848 | -0.125 | -3 | 0.830 |
IKKE |
0.848 | -0.144 | 1 | 0.731 |
WNK1 |
0.848 | -0.038 | -2 | 0.858 |
AMPKA1 |
0.848 | 0.008 | -3 | 0.804 |
RIPK3 |
0.847 | -0.085 | 3 | 0.685 |
PRKD2 |
0.847 | 0.032 | -3 | 0.716 |
MLK1 |
0.847 | -0.077 | 2 | 0.839 |
TSSK1 |
0.847 | 0.063 | -3 | 0.828 |
CDKL5 |
0.846 | 0.004 | -3 | 0.722 |
IKKA |
0.846 | -0.040 | -2 | 0.761 |
MST4 |
0.846 | -0.007 | 2 | 0.852 |
PIM1 |
0.845 | 0.015 | -3 | 0.727 |
PKN2 |
0.845 | 0.002 | -3 | 0.786 |
GRK6 |
0.845 | -0.033 | 1 | 0.891 |
FAM20C |
0.845 | 0.072 | 2 | 0.591 |
PDHK1 |
0.845 | -0.274 | 1 | 0.844 |
CAMLCK |
0.845 | -0.052 | -2 | 0.846 |
ULK1 |
0.845 | -0.157 | -3 | 0.767 |
HUNK |
0.845 | -0.124 | 2 | 0.822 |
SRPK1 |
0.845 | 0.031 | -3 | 0.686 |
DAPK2 |
0.844 | -0.043 | -3 | 0.806 |
NDR1 |
0.844 | -0.076 | -3 | 0.783 |
RSK2 |
0.844 | -0.022 | -3 | 0.710 |
MAPKAPK3 |
0.843 | -0.028 | -3 | 0.709 |
SKMLCK |
0.843 | -0.048 | -2 | 0.843 |
TGFBR1 |
0.843 | 0.077 | -2 | 0.812 |
PKCD |
0.843 | -0.000 | 2 | 0.816 |
AMPKA2 |
0.842 | 0.006 | -3 | 0.771 |
NUAK1 |
0.842 | 0.029 | -3 | 0.733 |
ALK4 |
0.842 | 0.031 | -2 | 0.838 |
MAPKAPK2 |
0.841 | 0.007 | -3 | 0.669 |
P70S6KB |
0.841 | -0.029 | -3 | 0.734 |
MARK4 |
0.841 | -0.085 | 4 | 0.819 |
WNK3 |
0.841 | -0.206 | 1 | 0.831 |
PLK1 |
0.841 | 0.017 | -2 | 0.853 |
IRE1 |
0.841 | -0.048 | 1 | 0.792 |
CAMK4 |
0.840 | -0.036 | -3 | 0.763 |
P90RSK |
0.840 | -0.057 | -3 | 0.706 |
GRK4 |
0.840 | -0.114 | -2 | 0.825 |
ICK |
0.840 | -0.037 | -3 | 0.771 |
LATS2 |
0.840 | -0.060 | -5 | 0.691 |
NEK9 |
0.839 | -0.133 | 2 | 0.866 |
BMPR1B |
0.839 | 0.091 | 1 | 0.829 |
ANKRD3 |
0.839 | -0.100 | 1 | 0.872 |
MLK2 |
0.839 | -0.086 | 2 | 0.845 |
MELK |
0.839 | -0.002 | -3 | 0.746 |
HIPK4 |
0.839 | -0.037 | 1 | 0.791 |
CAMK2D |
0.838 | -0.083 | -3 | 0.772 |
RSK3 |
0.838 | -0.057 | -3 | 0.698 |
BCKDK |
0.838 | -0.180 | -1 | 0.821 |
CDK8 |
0.838 | 0.002 | 1 | 0.671 |
IRE2 |
0.838 | -0.021 | 2 | 0.814 |
SRPK2 |
0.838 | 0.018 | -3 | 0.599 |
PKACG |
0.838 | -0.042 | -2 | 0.752 |
RIPK1 |
0.838 | -0.154 | 1 | 0.830 |
NIM1 |
0.837 | -0.101 | 3 | 0.743 |
DLK |
0.837 | -0.170 | 1 | 0.847 |
MASTL |
0.837 | -0.271 | -2 | 0.824 |
CAMK2B |
0.837 | 0.000 | 2 | 0.744 |
ACVR2B |
0.836 | 0.067 | -2 | 0.813 |
ATM |
0.836 | -0.006 | 1 | 0.825 |
ACVR2A |
0.836 | 0.035 | -2 | 0.796 |
PKR |
0.836 | -0.002 | 1 | 0.847 |
MNK2 |
0.835 | -0.008 | -2 | 0.796 |
TTBK2 |
0.835 | -0.170 | 2 | 0.731 |
PRKD3 |
0.835 | 0.000 | -3 | 0.675 |
CHK1 |
0.835 | 0.032 | -3 | 0.776 |
AURC |
0.835 | 0.013 | -2 | 0.654 |
CDK5 |
0.835 | 0.054 | 1 | 0.713 |
SRPK3 |
0.834 | 0.010 | -3 | 0.649 |
VRK2 |
0.833 | -0.105 | 1 | 0.886 |
CDK19 |
0.833 | 0.008 | 1 | 0.630 |
ALK2 |
0.833 | 0.061 | -2 | 0.816 |
GRK7 |
0.833 | 0.026 | 1 | 0.856 |
CDK13 |
0.832 | 0.020 | 1 | 0.665 |
MLK3 |
0.832 | -0.068 | 2 | 0.765 |
PAK3 |
0.832 | -0.078 | -2 | 0.779 |
PAK1 |
0.831 | -0.061 | -2 | 0.776 |
MLK4 |
0.831 | -0.058 | 2 | 0.758 |
PHKG1 |
0.831 | -0.049 | -3 | 0.767 |
LATS1 |
0.831 | -0.018 | -3 | 0.810 |
CDK7 |
0.830 | -0.015 | 1 | 0.688 |
MNK1 |
0.829 | -0.014 | -2 | 0.810 |
CHAK1 |
0.829 | -0.108 | 2 | 0.821 |
MEK1 |
0.829 | -0.184 | 2 | 0.844 |
AURB |
0.829 | -0.008 | -2 | 0.657 |
TLK2 |
0.829 | -0.066 | 1 | 0.805 |
PKCG |
0.828 | -0.055 | 2 | 0.761 |
P38A |
0.828 | 0.031 | 1 | 0.728 |
PKG2 |
0.828 | -0.002 | -2 | 0.684 |
PKCB |
0.828 | -0.041 | 2 | 0.764 |
PLK4 |
0.828 | -0.048 | 2 | 0.693 |
MSK2 |
0.827 | -0.097 | -3 | 0.659 |
PAK6 |
0.827 | -0.004 | -2 | 0.699 |
BMPR1A |
0.827 | 0.094 | 1 | 0.816 |
PLK3 |
0.827 | -0.073 | 2 | 0.759 |
JNK3 |
0.827 | 0.030 | 1 | 0.681 |
DYRK2 |
0.827 | -0.020 | 1 | 0.714 |
SGK3 |
0.826 | -0.012 | -3 | 0.703 |
PKACB |
0.826 | -0.001 | -2 | 0.682 |
PKCA |
0.826 | -0.044 | 2 | 0.761 |
PKCH |
0.826 | -0.061 | 2 | 0.766 |
CAMK2A |
0.826 | -0.062 | 2 | 0.750 |
QIK |
0.826 | -0.148 | -3 | 0.767 |
NEK2 |
0.826 | -0.135 | 2 | 0.844 |
CDK18 |
0.826 | 0.026 | 1 | 0.625 |
SIK |
0.826 | -0.075 | -3 | 0.696 |
PIM2 |
0.826 | -0.011 | -3 | 0.681 |
MYLK4 |
0.826 | -0.059 | -2 | 0.767 |
PERK |
0.826 | -0.113 | -2 | 0.835 |
PKCZ |
0.826 | -0.076 | 2 | 0.814 |
PRP4 |
0.826 | 0.062 | -3 | 0.768 |
RSK4 |
0.825 | -0.040 | -3 | 0.682 |
YSK4 |
0.825 | -0.164 | 1 | 0.769 |
CDK2 |
0.825 | -0.032 | 1 | 0.755 |
CLK1 |
0.825 | -0.007 | -3 | 0.686 |
HRI |
0.825 | -0.133 | -2 | 0.844 |
JNK2 |
0.825 | 0.044 | 1 | 0.634 |
CLK4 |
0.825 | -0.028 | -3 | 0.706 |
CDK1 |
0.824 | 0.007 | 1 | 0.654 |
QSK |
0.824 | -0.086 | 4 | 0.787 |
SNRK |
0.824 | -0.150 | 2 | 0.763 |
P38B |
0.824 | 0.039 | 1 | 0.669 |
CDK12 |
0.824 | 0.013 | 1 | 0.638 |
ERK1 |
0.824 | 0.017 | 1 | 0.648 |
PAK2 |
0.824 | -0.107 | -2 | 0.762 |
SSTK |
0.823 | 0.010 | 4 | 0.770 |
BRAF |
0.823 | -0.082 | -4 | 0.836 |
AKT2 |
0.823 | -0.018 | -3 | 0.623 |
PHKG2 |
0.822 | -0.014 | -3 | 0.750 |
IRAK4 |
0.822 | -0.065 | 1 | 0.806 |
ERK2 |
0.822 | -0.012 | 1 | 0.695 |
P38G |
0.822 | 0.029 | 1 | 0.565 |
CLK2 |
0.822 | 0.044 | -3 | 0.697 |
DNAPK |
0.821 | -0.022 | 1 | 0.742 |
MSK1 |
0.821 | -0.063 | -3 | 0.673 |
SMG1 |
0.821 | -0.095 | 1 | 0.815 |
CDK9 |
0.821 | -0.025 | 1 | 0.673 |
GRK2 |
0.821 | -0.094 | -2 | 0.716 |
DCAMKL1 |
0.821 | -0.046 | -3 | 0.737 |
CAMK1G |
0.820 | -0.068 | -3 | 0.688 |
AURA |
0.820 | -0.033 | -2 | 0.627 |
HIPK1 |
0.820 | 0.003 | 1 | 0.724 |
BRSK2 |
0.820 | -0.132 | -3 | 0.754 |
CDK17 |
0.820 | 0.007 | 1 | 0.577 |
MARK2 |
0.820 | -0.097 | 4 | 0.710 |
TLK1 |
0.820 | -0.095 | -2 | 0.833 |
BRSK1 |
0.819 | -0.127 | -3 | 0.728 |
PRKX |
0.819 | 0.005 | -3 | 0.637 |
WNK4 |
0.819 | -0.141 | -2 | 0.843 |
MAPKAPK5 |
0.818 | -0.148 | -3 | 0.618 |
CK1E |
0.818 | -0.040 | -3 | 0.533 |
DRAK1 |
0.818 | -0.139 | 1 | 0.808 |
MEKK1 |
0.818 | -0.175 | 1 | 0.813 |
HIPK2 |
0.818 | 0.009 | 1 | 0.618 |
HIPK3 |
0.818 | -0.011 | 1 | 0.732 |
NEK5 |
0.817 | -0.114 | 1 | 0.848 |
MEKK2 |
0.817 | -0.137 | 2 | 0.839 |
ZAK |
0.817 | -0.162 | 1 | 0.776 |
MEKK3 |
0.817 | -0.188 | 1 | 0.807 |
MARK3 |
0.817 | -0.101 | 4 | 0.745 |
DYRK1A |
0.816 | -0.035 | 1 | 0.758 |
DCAMKL2 |
0.816 | -0.046 | -3 | 0.758 |
MEK5 |
0.816 | -0.291 | 2 | 0.853 |
P70S6K |
0.815 | -0.067 | -3 | 0.627 |
AKT1 |
0.815 | -0.011 | -3 | 0.645 |
CDK3 |
0.815 | 0.017 | 1 | 0.596 |
PKCT |
0.814 | -0.065 | 2 | 0.777 |
PINK1 |
0.814 | -0.201 | 1 | 0.816 |
CDK16 |
0.814 | 0.035 | 1 | 0.600 |
MPSK1 |
0.814 | -0.014 | 1 | 0.769 |
EEF2K |
0.814 | 0.031 | 3 | 0.815 |
SMMLCK |
0.813 | -0.087 | -3 | 0.750 |
PKACA |
0.813 | -0.017 | -2 | 0.628 |
CAMK1D |
0.813 | -0.030 | -3 | 0.615 |
TAO3 |
0.813 | -0.092 | 1 | 0.804 |
P38D |
0.813 | 0.047 | 1 | 0.577 |
CDK14 |
0.813 | 0.001 | 1 | 0.667 |
MST3 |
0.813 | -0.076 | 2 | 0.836 |
GAK |
0.812 | 0.003 | 1 | 0.854 |
MARK1 |
0.812 | -0.139 | 4 | 0.769 |
IRAK1 |
0.811 | -0.196 | -1 | 0.754 |
ERK7 |
0.811 | 0.023 | 2 | 0.564 |
NEK8 |
0.810 | -0.158 | 2 | 0.859 |
TTBK1 |
0.810 | -0.179 | 2 | 0.659 |
DAPK3 |
0.810 | -0.012 | -3 | 0.742 |
TAO2 |
0.810 | -0.079 | 2 | 0.867 |
CAMKK1 |
0.810 | -0.153 | -2 | 0.780 |
CK1D |
0.810 | -0.039 | -3 | 0.487 |
PDK1 |
0.809 | -0.065 | 1 | 0.845 |
PASK |
0.809 | -0.101 | -3 | 0.795 |
CK1G1 |
0.808 | -0.095 | -3 | 0.540 |
PKCI |
0.808 | -0.066 | 2 | 0.783 |
GRK3 |
0.808 | -0.085 | -2 | 0.670 |
PKN1 |
0.808 | -0.017 | -3 | 0.648 |
GSK3B |
0.807 | -0.069 | 4 | 0.429 |
CDK10 |
0.807 | 0.022 | 1 | 0.651 |
VRK1 |
0.806 | -0.050 | 2 | 0.871 |
CK1A2 |
0.806 | -0.046 | -3 | 0.482 |
CAMK1A |
0.805 | -0.008 | -3 | 0.592 |
GSK3A |
0.805 | -0.044 | 4 | 0.443 |
DYRK1B |
0.805 | -0.043 | 1 | 0.674 |
DYRK3 |
0.804 | -0.043 | 1 | 0.723 |
CDK6 |
0.804 | 0.023 | 1 | 0.643 |
MST2 |
0.804 | -0.107 | 1 | 0.812 |
MAP3K15 |
0.803 | -0.105 | 1 | 0.769 |
MEKK6 |
0.803 | -0.103 | 1 | 0.792 |
CK2A2 |
0.803 | -0.013 | 1 | 0.737 |
DYRK4 |
0.803 | -0.033 | 1 | 0.638 |
CHK2 |
0.803 | -0.038 | -3 | 0.568 |
LKB1 |
0.803 | -0.145 | -3 | 0.775 |
CDK4 |
0.802 | 0.018 | 1 | 0.626 |
PAK5 |
0.802 | -0.077 | -2 | 0.634 |
TNIK |
0.802 | -0.038 | 3 | 0.828 |
NEK4 |
0.802 | -0.162 | 1 | 0.787 |
PKCE |
0.802 | -0.046 | 2 | 0.750 |
NEK11 |
0.802 | -0.237 | 1 | 0.799 |
JNK1 |
0.802 | -0.005 | 1 | 0.638 |
PLK2 |
0.802 | -0.040 | -3 | 0.749 |
BUB1 |
0.802 | 0.079 | -5 | 0.790 |
HGK |
0.802 | -0.075 | 3 | 0.836 |
DAPK1 |
0.801 | -0.048 | -3 | 0.718 |
CAMKK2 |
0.801 | -0.196 | -2 | 0.771 |
MINK |
0.801 | -0.086 | 1 | 0.777 |
NEK1 |
0.800 | -0.098 | 1 | 0.816 |
AKT3 |
0.799 | -0.028 | -3 | 0.557 |
GCK |
0.799 | -0.126 | 1 | 0.790 |
LRRK2 |
0.799 | -0.181 | 2 | 0.873 |
PAK4 |
0.798 | -0.074 | -2 | 0.639 |
MRCKB |
0.797 | -0.037 | -3 | 0.677 |
TAK1 |
0.797 | -0.164 | 1 | 0.827 |
MST1 |
0.797 | -0.120 | 1 | 0.790 |
SGK1 |
0.797 | -0.041 | -3 | 0.539 |
MAK |
0.796 | 0.017 | -2 | 0.708 |
ROCK2 |
0.795 | -0.034 | -3 | 0.733 |
LOK |
0.795 | -0.126 | -2 | 0.785 |
MRCKA |
0.794 | -0.064 | -3 | 0.693 |
KHS1 |
0.794 | -0.058 | 1 | 0.768 |
PDHK3_TYR |
0.794 | 0.103 | 4 | 0.905 |
MOK |
0.793 | -0.006 | 1 | 0.747 |
RIPK2 |
0.793 | -0.248 | 1 | 0.743 |
SBK |
0.793 | -0.044 | -3 | 0.502 |
HPK1 |
0.792 | -0.124 | 1 | 0.770 |
DMPK1 |
0.792 | 0.011 | -3 | 0.712 |
YSK1 |
0.792 | -0.110 | 2 | 0.840 |
TTK |
0.792 | -0.026 | -2 | 0.838 |
CK2A1 |
0.791 | -0.040 | 1 | 0.711 |
KHS2 |
0.791 | -0.033 | 1 | 0.776 |
MEK2 |
0.791 | -0.271 | 2 | 0.839 |
PBK |
0.790 | -0.052 | 1 | 0.779 |
OSR1 |
0.790 | -0.051 | 2 | 0.822 |
PKG1 |
0.789 | -0.055 | -2 | 0.609 |
STK33 |
0.788 | -0.209 | 2 | 0.643 |
SLK |
0.787 | -0.155 | -2 | 0.727 |
ALPHAK3 |
0.786 | -0.011 | -1 | 0.780 |
NEK3 |
0.786 | -0.164 | 1 | 0.765 |
BIKE |
0.785 | 0.014 | 1 | 0.724 |
TESK1_TYR |
0.784 | -0.088 | 3 | 0.828 |
ROCK1 |
0.783 | -0.041 | -3 | 0.692 |
PDHK4_TYR |
0.783 | -0.029 | 2 | 0.872 |
EPHA6 |
0.783 | 0.129 | -1 | 0.873 |
CRIK |
0.783 | -0.038 | -3 | 0.643 |
MAP2K6_TYR |
0.782 | -0.071 | -1 | 0.873 |
HASPIN |
0.782 | -0.045 | -1 | 0.680 |
MAP2K4_TYR |
0.782 | -0.140 | -1 | 0.861 |
BMPR2_TYR |
0.781 | 0.018 | -1 | 0.877 |
PKMYT1_TYR |
0.781 | -0.116 | 3 | 0.801 |
PINK1_TYR |
0.781 | -0.101 | 1 | 0.872 |
MAP2K7_TYR |
0.781 | -0.224 | 2 | 0.877 |
EPHB4 |
0.781 | 0.074 | -1 | 0.844 |
ROS1 |
0.780 | -0.009 | 3 | 0.768 |
LIMK2_TYR |
0.780 | -0.023 | -3 | 0.847 |
MYO3B |
0.779 | -0.082 | 2 | 0.848 |
TYK2 |
0.779 | -0.054 | 1 | 0.831 |
TYRO3 |
0.779 | -0.041 | 3 | 0.786 |
PDHK1_TYR |
0.778 | -0.098 | -1 | 0.886 |
ASK1 |
0.778 | -0.174 | 1 | 0.757 |
ABL2 |
0.778 | 0.032 | -1 | 0.811 |
FER |
0.778 | 0.025 | 1 | 0.934 |
RET |
0.777 | -0.085 | 1 | 0.835 |
MYO3A |
0.776 | -0.107 | 1 | 0.765 |
JAK2 |
0.776 | -0.055 | 1 | 0.823 |
TXK |
0.775 | 0.087 | 1 | 0.869 |
YES1 |
0.775 | 0.014 | -1 | 0.822 |
MST1R |
0.775 | -0.086 | 3 | 0.780 |
CSF1R |
0.775 | -0.043 | 3 | 0.767 |
YANK3 |
0.775 | -0.098 | 2 | 0.394 |
TAO1 |
0.775 | -0.130 | 1 | 0.722 |
INSRR |
0.774 | -0.001 | 3 | 0.728 |
LCK |
0.774 | 0.112 | -1 | 0.828 |
ABL1 |
0.773 | 0.007 | -1 | 0.802 |
LIMK1_TYR |
0.773 | -0.176 | 2 | 0.889 |
FGR |
0.773 | -0.030 | 1 | 0.894 |
HCK |
0.773 | 0.047 | -1 | 0.819 |
EPHB2 |
0.773 | 0.086 | -1 | 0.829 |
EPHB1 |
0.772 | 0.036 | 1 | 0.895 |
EPHB3 |
0.772 | 0.052 | -1 | 0.834 |
FLT3 |
0.771 | -0.019 | 3 | 0.792 |
BLK |
0.771 | 0.105 | -1 | 0.830 |
JAK3 |
0.770 | -0.042 | 1 | 0.818 |
ITK |
0.770 | 0.001 | -1 | 0.793 |
AAK1 |
0.770 | 0.054 | 1 | 0.616 |
TNK2 |
0.769 | -0.024 | 3 | 0.738 |
PDGFRB |
0.769 | -0.081 | 3 | 0.790 |
DDR1 |
0.769 | -0.139 | 4 | 0.821 |
SRMS |
0.769 | -0.015 | 1 | 0.908 |
EPHA4 |
0.769 | 0.012 | 2 | 0.744 |
CK1A |
0.768 | -0.091 | -3 | 0.406 |
STLK3 |
0.766 | -0.206 | 1 | 0.746 |
MERTK |
0.766 | -0.038 | 3 | 0.735 |
FGFR1 |
0.766 | -0.074 | 3 | 0.742 |
KIT |
0.766 | -0.083 | 3 | 0.765 |
TNNI3K_TYR |
0.766 | -0.026 | 1 | 0.814 |
BMX |
0.765 | 0.013 | -1 | 0.726 |
FGFR2 |
0.765 | -0.101 | 3 | 0.744 |
ALK |
0.765 | -0.051 | 3 | 0.739 |
KDR |
0.765 | -0.073 | 3 | 0.726 |
TEK |
0.765 | -0.080 | 3 | 0.726 |
FRK |
0.764 | 0.042 | -1 | 0.827 |
TNK1 |
0.764 | -0.079 | 3 | 0.766 |
AXL |
0.764 | -0.093 | 3 | 0.733 |
FYN |
0.764 | 0.092 | -1 | 0.814 |
MET |
0.764 | -0.041 | 3 | 0.759 |
JAK1 |
0.764 | -0.050 | 1 | 0.758 |
TEC |
0.763 | -0.036 | -1 | 0.725 |
LTK |
0.763 | -0.057 | 3 | 0.739 |
BTK |
0.763 | -0.085 | -1 | 0.751 |
PDGFRA |
0.761 | -0.143 | 3 | 0.787 |
NTRK1 |
0.759 | -0.114 | -1 | 0.832 |
EPHA7 |
0.759 | -0.016 | 2 | 0.766 |
WEE1_TYR |
0.758 | -0.079 | -1 | 0.759 |
EPHA1 |
0.757 | -0.052 | 3 | 0.752 |
INSR |
0.757 | -0.098 | 3 | 0.707 |
LYN |
0.757 | -0.022 | 3 | 0.698 |
ERBB2 |
0.757 | -0.091 | 1 | 0.826 |
EPHA3 |
0.756 | -0.070 | 2 | 0.738 |
NEK10_TYR |
0.756 | -0.150 | 1 | 0.685 |
EPHA5 |
0.756 | 0.013 | 2 | 0.740 |
NTRK3 |
0.755 | -0.080 | -1 | 0.794 |
PTK2B |
0.755 | -0.033 | -1 | 0.771 |
PTK6 |
0.755 | -0.173 | -1 | 0.731 |
NTRK2 |
0.755 | -0.159 | 3 | 0.707 |
EPHA8 |
0.754 | 0.018 | -1 | 0.829 |
SRC |
0.754 | -0.005 | -1 | 0.802 |
FGFR3 |
0.753 | -0.125 | 3 | 0.715 |
MUSK |
0.752 | 0.005 | 1 | 0.751 |
FLT4 |
0.752 | -0.148 | 3 | 0.702 |
DDR2 |
0.752 | -0.048 | 3 | 0.717 |
MATK |
0.752 | -0.092 | -1 | 0.760 |
FLT1 |
0.751 | -0.114 | -1 | 0.844 |
SYK |
0.750 | 0.090 | -1 | 0.806 |
EGFR |
0.750 | -0.016 | 1 | 0.756 |
CK1G3 |
0.749 | -0.103 | -3 | 0.364 |
PTK2 |
0.746 | 0.051 | -1 | 0.812 |
CSK |
0.746 | -0.131 | 2 | 0.776 |
IGF1R |
0.744 | -0.085 | 3 | 0.647 |
EPHA2 |
0.743 | -0.011 | -1 | 0.793 |
FGFR4 |
0.742 | -0.097 | -1 | 0.780 |
YANK2 |
0.740 | -0.128 | 2 | 0.411 |
ERBB4 |
0.740 | 0.010 | 1 | 0.774 |
CK1G2 |
0.734 | -0.074 | -3 | 0.457 |
FES |
0.733 | -0.076 | -1 | 0.712 |
ZAP70 |
0.730 | 0.029 | -1 | 0.739 |