Motif 743 (n=122)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NMZ7 | COL6A6 | S816 | ochoa | Collagen alpha-6(VI) chain | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| O00161 | SNAP23 | S23 | ochoa|psp | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O00170 | AIP | S131 | psp | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O14770 | MEIS2 | S206 | ochoa | Homeobox protein Meis2 (Meis1-related protein 1) | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. {ECO:0000269|PubMed:10764806, ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:21746878}. |
| O43491 | EPB41L2 | S58 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60664 | PLIN3 | S137 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75363 | BCAS1 | S62 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75955 | FLOT1 | S382 | ochoa | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| O95071 | UBR5 | S694 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95071 | UBR5 | S1701 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95400 | CD2BP2 | S68 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| P04035 | HMGCR | S420 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P05165 | PCCA | S251 | ochoa | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:8434582). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:10101253, PubMed:6765947, PubMed:8434582). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P0DTA4, ECO:0000250|UniProtKB:Q5LUF3, ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:6765947, ECO:0000269|PubMed:8434582}. |
| P07451 | CA3 | S218 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P0DMV8 | HSPA1A | S418 | ochoa|psp | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S418 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P12882 | MYH1 | S1303 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1299 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13521 | SCG2 | S555 | ochoa | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
| P13533 | MYH6 | S1301 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P14618 | PKM | S425 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P17661 | DES | S298 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P28290 | ITPRID2 | S424 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P31942 | HNRNPH3 | S56 | ochoa | Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) | Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. |
| P34931 | HSPA1L | S420 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35579 | MYH9 | S1915 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P37275 | ZEB1 | S455 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P38398 | BRCA1 | S377 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42166 | TMPO | S166 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42858 | HTT | S462 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P42858 | HTT | S463 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P43243 | MATR3 | S195 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P43307 | SSR1 | S246 | ochoa | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. |
| P49902 | NT5C2 | S417 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P50454 | SERPINH1 | S149 | ochoa | Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| P50851 | LRBA | S1051 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51114 | FXR1 | S499 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P61764 | STXBP1 | S506 | ochoa | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P82094 | TMF1 | S142 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q03164 | KMT2A | S2690 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q08211 | DHX9 | S1032 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12893 | TMEM115 | S266 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
| Q12929 | EPS8 | S494 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13427 | PPIG | S716 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13554 | CAMK2B | S394 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13563 | PKD2 | S801 | ochoa|psp | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q14008 | CKAP5 | S2004 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14151 | SAFB2 | S282 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14247 | CTTN | S155 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14684 | RRP1B | S629 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q15398 | DLGAP5 | S796 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15424 | SAFB | S283 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15911 | ZFHX3 | S518 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16665 | HIF1A | S576 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q5SW79 | CEP170 | S724 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5TB80 | CEP162 | S144 | ochoa | Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}. |
| Q5TF39 | MFSD4B | S473 | ochoa | Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) | May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. {ECO:0000250|UniProtKB:Q80T22}. |
| Q5VT52 | RPRD2 | S816 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q69YH5 | CDCA2 | S198 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6NZI2 | CAVIN1 | S25 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6ZNJ1 | NBEAL2 | S293 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZSZ6 | TSHZ1 | S65 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q70CQ2 | USP34 | S3393 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q7L2Z9 | CENPQ | S138 | ochoa|psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q7L4I2 | RSRC2 | S383 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7Z3K6 | MIER3 | S122 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q8IWS0 | PHF6 | S192 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IY81 | FTSJ3 | S448 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8N108 | MIER1 | S130 | ochoa | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}. |
| Q8NC44 | RETREG2 | S402 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8NHV4 | NEDD1 | S404 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TB72 | PUM2 | S100 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8WY36 | BBX | S642 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q92538 | GBF1 | S325 | ochoa | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) | Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}. |
| Q92556 | ELMO1 | S341 | ochoa | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158}. |
| Q92558 | WASF1 | S103 | ochoa | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}. |
| Q92783 | STAM | S202 | ochoa | Signal transducing adapter molecule 1 (STAM-1) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}. |
| Q96FS4 | SIPA1 | S842 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96K49 | TMEM87B | S521 | ochoa | Transmembrane protein 87B | May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. |
| Q96RG2 | PASK | S533 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96S38 | RPS6KC1 | S872 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96TC7 | RMDN3 | S232 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
| Q9BPZ7 | MAPKAP1 | S459 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BST9 | RTKN | S218 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9BVS4 | RIOK2 | S417 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9C0B5 | ZDHHC5 | S577 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S919 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZR1 | SENP6 | S335 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9GZY8 | MFF | S233 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H4L5 | OSBPL3 | S330 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H4L7 | SMARCAD1 | S57 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9HCH5 | SYTL2 | S516 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NY27 | PPP4R2 | S223 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NYA4 | MTMR4 | S598 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}. |
| Q9UDY2 | TJP2 | S902 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UER7 | DAXX | S402 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UGU0 | TCF20 | S524 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UK76 | JPT1 | S91 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9UKX2 | MYH2 | S1305 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UMS6 | SYNPO2 | S263 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMS6 | SYNPO2 | S329 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPV7 | PHF24 | S72 | ochoa | PHD finger protein 24 | None |
| Q9Y2W1 | THRAP3 | S559 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3B9 | RRP15 | S84 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y6W5 | WASF2 | S102 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| Q12888 | TP53BP1 | S197 | Sugiyama | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| O00115 | DNASE2 | S57 | Sugiyama | Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162). {ECO:0000269|PubMed:29259162, ECO:0000269|PubMed:31775019}. |
| O75676 | RPS6KA4 | S693 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| Q86TB9 | PATL1 | S564 | Sugiyama | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| P07384 | CAPN1 | S418 | EPSD|PSP | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| Q08289 | CACNB2 | S533 | ELM|EPSD | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}. |
| P33981 | TTK | S214 | SIGNOR | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| Q8N6T3 | ARFGAP1 | S277 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q9NYU2 | UGGT1 | S955 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| O43399 | TPD52L2 | S103 | Sugiyama | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| Q8TD08 | MAPK15 | S191 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q8TD08 | MAPK15 | S349 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q15382 | RHEB | S148 | Sugiyama | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| Q96GD4 | AURKB | S61 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
| Q9UNZ2 | NSFL1C | S212 | Sugiyama | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q00403 | GTF2B | S99 | Sugiyama | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| O00506 | STK25 | S149 | Sugiyama | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 2.220446e-16 | 15.654 |
| R-HSA-2262752 | Cellular responses to stress | 1.039550e-05 | 4.983 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.682847e-06 | 5.014 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 2.240411e-03 | 2.650 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 5.392311e-03 | 2.268 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 6.930841e-03 | 2.159 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.943358e-02 | 1.711 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.943358e-02 | 1.711 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.943358e-02 | 1.711 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.943358e-02 | 1.711 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.943358e-02 | 1.711 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.943358e-02 | 1.711 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.943358e-02 | 1.711 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.943358e-02 | 1.711 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.176127e-02 | 1.662 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.528682e-02 | 1.816 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.042782e-02 | 1.690 |
| R-HSA-9664407 | Parasite infection | 1.994163e-02 | 1.700 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.994163e-02 | 1.700 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.994163e-02 | 1.700 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.528682e-02 | 1.816 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.183878e-02 | 1.661 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.528682e-02 | 1.816 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.183878e-02 | 1.661 |
| R-HSA-9833482 | PKR-mediated signaling | 1.146512e-02 | 1.941 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.478130e-02 | 1.830 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.806132e-02 | 1.743 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.547694e-02 | 1.594 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.547694e-02 | 1.594 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.572010e-02 | 1.590 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.900917e-02 | 1.537 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.718197e-02 | 1.243 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 9.348603e-02 | 1.029 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.023429e-01 | 0.990 |
| R-HSA-9613354 | Lipophagy | 1.111137e-01 | 0.954 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.197994e-01 | 0.922 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 1.284007e-01 | 0.891 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.369185e-01 | 0.864 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.369185e-01 | 0.864 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.369185e-01 | 0.864 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.452061e-02 | 1.351 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.701704e-01 | 0.769 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.701704e-01 | 0.769 |
| R-HSA-390522 | Striated Muscle Contraction | 5.934465e-02 | 1.227 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.863159e-01 | 0.730 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.099505e-01 | 0.678 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.099505e-01 | 0.678 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.176762e-01 | 0.662 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.176762e-01 | 0.662 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.176762e-01 | 0.662 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.176762e-01 | 0.662 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.329029e-01 | 0.633 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.329029e-01 | 0.633 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.624785e-01 | 0.581 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.604610e-02 | 1.180 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.604610e-02 | 1.180 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.909208e-01 | 0.536 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.909208e-01 | 0.536 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.544043e-01 | 0.811 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.544043e-01 | 0.811 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.612511e-01 | 0.792 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.646953e-01 | 0.783 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.891381e-01 | 0.723 |
| R-HSA-380287 | Centrosome maturation | 1.962126e-01 | 0.707 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.464425e-01 | 0.608 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.898707e-01 | 0.538 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.696936e-01 | 0.569 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.454376e-02 | 1.128 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.369185e-01 | 0.864 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.863159e-01 | 0.730 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.392160e-01 | 0.621 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.802726e-02 | 1.236 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.863159e-01 | 0.730 |
| R-HSA-9620244 | Long-term potentiation | 2.624785e-01 | 0.581 |
| R-HSA-8849473 | PTK6 Expression | 9.348603e-02 | 1.029 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.863159e-01 | 0.730 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.182728e-01 | 0.497 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.278080e-01 | 0.893 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.551106e-02 | 1.122 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.182728e-01 | 0.497 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 9.677043e-02 | 1.014 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.908597e-02 | 1.050 |
| R-HSA-5693538 | Homology Directed Repair | 1.411055e-01 | 0.850 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.993636e-02 | 1.399 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.453536e-01 | 0.838 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.021491e-01 | 0.694 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.329029e-01 | 0.633 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.768386e-01 | 0.558 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.507308e-02 | 1.125 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.021491e-01 | 0.694 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.485696e-02 | 1.348 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.364783e-01 | 0.626 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 1.716222e-01 | 0.765 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.404055e-01 | 0.619 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.408938e-01 | 0.851 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.115347e-01 | 0.506 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.954442e-02 | 1.403 |
| R-HSA-5617833 | Cilium Assembly | 5.613333e-02 | 1.251 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.408938e-01 | 0.851 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.821004e-01 | 0.740 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 7.551106e-02 | 1.122 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 8.454239e-02 | 1.073 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.284007e-01 | 0.891 |
| R-HSA-71032 | Propionyl-CoA catabolism | 1.284007e-01 | 0.891 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.369185e-01 | 0.864 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.253267e-01 | 0.647 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.551926e-01 | 0.593 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.283984e-01 | 0.641 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.786137e-01 | 0.748 |
| R-HSA-68877 | Mitotic Prometaphase | 1.564648e-01 | 0.806 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.053077e-01 | 0.978 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.479227e-01 | 0.830 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 6.461465e-02 | 1.190 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.681525e-01 | 0.774 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.942711e-01 | 0.712 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.954442e-02 | 1.403 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.978593e-01 | 0.526 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.182728e-01 | 0.497 |
| R-HSA-1474290 | Collagen formation | 2.717799e-01 | 0.566 |
| R-HSA-182971 | EGFR downregulation | 5.173992e-02 | 1.286 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 9.348603e-02 | 1.029 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 1.537067e-01 | 0.813 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.688243e-02 | 1.329 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.022094e-01 | 0.991 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.404055e-01 | 0.619 |
| R-HSA-429947 | Deadenylation of mRNA | 2.551926e-01 | 0.593 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.696936e-01 | 0.569 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.768386e-01 | 0.558 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.047304e-01 | 0.516 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.926710e-01 | 0.715 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.652375e-01 | 0.576 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.197994e-01 | 0.922 |
| R-HSA-196780 | Biotin transport and metabolism | 1.701704e-01 | 0.769 |
| R-HSA-9659379 | Sensory processing of sound | 5.495793e-02 | 1.260 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.044837e-02 | 1.094 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.575983e-02 | 1.182 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.646953e-01 | 0.783 |
| R-HSA-199991 | Membrane Trafficking | 3.285283e-02 | 1.483 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.442469e-01 | 0.841 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.254710e-02 | 1.371 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.426841e-01 | 0.615 |
| R-HSA-164944 | Nef and signal transduction | 8.454239e-02 | 1.073 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.619788e-01 | 0.791 |
| R-HSA-419037 | NCAM1 interactions | 7.003541e-02 | 1.155 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.978593e-01 | 0.526 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.170944e-01 | 0.931 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.320008e-01 | 0.635 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.160695e-01 | 0.935 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.345344e-02 | 1.272 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.111137e-01 | 0.954 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.021491e-01 | 0.694 |
| R-HSA-9755088 | Ribavirin ADME | 2.329029e-01 | 0.633 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.696936e-01 | 0.569 |
| R-HSA-112316 | Neuronal System | 2.062951e-01 | 0.686 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.785967e-01 | 0.748 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.179463e-01 | 0.928 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.624785e-01 | 0.581 |
| R-HSA-397014 | Muscle contraction | 1.947937e-01 | 0.710 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.733491e-01 | 0.761 |
| R-HSA-392517 | Rap1 signalling | 2.099505e-01 | 0.678 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.176762e-01 | 0.662 |
| R-HSA-2161541 | Abacavir metabolism | 2.253267e-01 | 0.647 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.329029e-01 | 0.633 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.551926e-01 | 0.593 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.551926e-01 | 0.593 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.891381e-01 | 0.723 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 2.021491e-01 | 0.694 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.309412e-01 | 0.883 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.768386e-01 | 0.558 |
| R-HSA-112311 | Neurotransmitter clearance | 2.978593e-01 | 0.526 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.440342e-02 | 1.191 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.215827e-02 | 1.375 |
| R-HSA-177929 | Signaling by EGFR | 1.309412e-01 | 0.883 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.392160e-01 | 0.621 |
| R-HSA-8848021 | Signaling by PTK6 | 1.544043e-01 | 0.811 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.544043e-01 | 0.811 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.284007e-01 | 0.891 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.782826e-01 | 0.749 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 2.768386e-01 | 0.558 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.768386e-01 | 0.558 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.182728e-01 | 0.497 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.395601e-01 | 0.855 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.753168e-01 | 0.756 |
| R-HSA-9658195 | Leishmania infection | 1.753168e-01 | 0.756 |
| R-HSA-1640170 | Cell Cycle | 2.883753e-01 | 0.540 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.023429e-01 | 0.990 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.023429e-01 | 0.990 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 6.730668e-02 | 1.172 |
| R-HSA-2028269 | Signaling by Hippo | 1.942711e-01 | 0.712 |
| R-HSA-2161522 | Abacavir ADME | 2.696936e-01 | 0.569 |
| R-HSA-68882 | Mitotic Anaphase | 2.027904e-01 | 0.693 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.928923e-02 | 1.307 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.099505e-01 | 0.678 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.048050e-01 | 0.689 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.510028e-01 | 0.821 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 7.559917e-02 | 1.121 |
| R-HSA-422356 | Regulation of insulin secretion | 2.898707e-01 | 0.538 |
| R-HSA-5688426 | Deubiquitination | 1.351563e-01 | 0.869 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.934258e-02 | 1.533 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.624785e-01 | 0.581 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.917358e-01 | 0.535 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.934465e-02 | 1.227 |
| R-HSA-1989781 | PPARA activates gene expression | 2.416678e-01 | 0.617 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.404055e-01 | 0.619 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.404055e-01 | 0.619 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.115077e-01 | 0.507 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.468765e-01 | 0.608 |
| R-HSA-70268 | Pyruvate metabolism | 2.428280e-01 | 0.615 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.918643e-02 | 1.004 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 7.559917e-02 | 1.121 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.696936e-01 | 0.569 |
| R-HSA-189200 | Cellular hexose transport | 2.404055e-01 | 0.619 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.478352e-01 | 0.606 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.276616e-01 | 0.894 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.908718e-02 | 1.408 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.478352e-01 | 0.606 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.220488e-02 | 1.375 |
| R-HSA-201556 | Signaling by ALK | 7.559917e-02 | 1.121 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.544043e-01 | 0.811 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.182728e-01 | 0.497 |
| R-HSA-194138 | Signaling by VEGF | 5.002194e-02 | 1.301 |
| R-HSA-191273 | Cholesterol biosynthesis | 2.068847e-01 | 0.684 |
| R-HSA-70171 | Glycolysis | 2.970946e-01 | 0.527 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.070974e-01 | 0.970 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.030142e-02 | 1.044 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.629903e-02 | 1.117 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.104561e-01 | 0.677 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.069237e-02 | 1.093 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.862555e-01 | 0.543 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.612511e-01 | 0.792 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.115347e-01 | 0.506 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.546286e-01 | 0.811 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.862085e-02 | 1.164 |
| R-HSA-6806834 | Signaling by MET | 2.140339e-01 | 0.670 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.723757e-01 | 0.764 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.997624e-01 | 0.699 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.428280e-01 | 0.615 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.249454e-01 | 0.488 |
| R-HSA-69275 | G2/M Transition | 3.264325e-01 | 0.486 |
| R-HSA-6798695 | Neutrophil degranulation | 3.290024e-01 | 0.483 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.315531e-01 | 0.479 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.315531e-01 | 0.479 |
| R-HSA-5673000 | RAF activation | 3.315531e-01 | 0.479 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.315531e-01 | 0.479 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.317781e-01 | 0.479 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.380965e-01 | 0.471 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.380965e-01 | 0.471 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.445762e-01 | 0.463 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.445762e-01 | 0.463 |
| R-HSA-111933 | Calmodulin induced events | 3.445762e-01 | 0.463 |
| R-HSA-111997 | CaM pathway | 3.445762e-01 | 0.463 |
| R-HSA-163560 | Triglyceride catabolism | 3.445762e-01 | 0.463 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.507804e-01 | 0.455 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.509929e-01 | 0.455 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.509929e-01 | 0.455 |
| R-HSA-8948216 | Collagen chain trimerization | 3.509929e-01 | 0.455 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.509929e-01 | 0.455 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.543164e-01 | 0.451 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.573472e-01 | 0.447 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.573472e-01 | 0.447 |
| R-HSA-68886 | M Phase | 3.620855e-01 | 0.441 |
| R-HSA-913531 | Interferon Signaling | 3.640261e-01 | 0.439 |
| R-HSA-70326 | Glucose metabolism | 3.683915e-01 | 0.434 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.698709e-01 | 0.432 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.698709e-01 | 0.432 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.698709e-01 | 0.432 |
| R-HSA-5260271 | Diseases of Immune System | 3.698709e-01 | 0.432 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.760415e-01 | 0.425 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.760415e-01 | 0.425 |
| R-HSA-9694548 | Maturation of spike protein | 3.760415e-01 | 0.425 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.760415e-01 | 0.425 |
| R-HSA-5357801 | Programmed Cell Death | 3.797291e-01 | 0.421 |
| R-HSA-167161 | HIV Transcription Initiation | 3.821521e-01 | 0.418 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.821521e-01 | 0.418 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.821521e-01 | 0.418 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.821521e-01 | 0.418 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.821521e-01 | 0.418 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.821521e-01 | 0.418 |
| R-HSA-73886 | Chromosome Maintenance | 3.823470e-01 | 0.418 |
| R-HSA-165159 | MTOR signalling | 3.882032e-01 | 0.411 |
| R-HSA-111996 | Ca-dependent events | 3.882032e-01 | 0.411 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.941954e-01 | 0.404 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.941954e-01 | 0.404 |
| R-HSA-774815 | Nucleosome assembly | 4.060054e-01 | 0.391 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.060054e-01 | 0.391 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.060054e-01 | 0.391 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.060054e-01 | 0.391 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.060054e-01 | 0.391 |
| R-HSA-69481 | G2/M Checkpoints | 4.064472e-01 | 0.391 |
| R-HSA-9675135 | Diseases of DNA repair | 4.118243e-01 | 0.385 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.118243e-01 | 0.385 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.118243e-01 | 0.385 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.118243e-01 | 0.385 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.118243e-01 | 0.385 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.118243e-01 | 0.385 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.118243e-01 | 0.385 |
| R-HSA-75153 | Apoptotic execution phase | 4.118243e-01 | 0.385 |
| R-HSA-437239 | Recycling pathway of L1 | 4.175866e-01 | 0.379 |
| R-HSA-8951664 | Neddylation | 4.217502e-01 | 0.375 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.232927e-01 | 0.373 |
| R-HSA-5576891 | Cardiac conduction | 4.233854e-01 | 0.373 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.267435e-01 | 0.370 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.289433e-01 | 0.368 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.289433e-01 | 0.368 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.349371e-01 | 0.362 |
| R-HSA-8957322 | Metabolism of steroids | 4.371144e-01 | 0.359 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.394879e-01 | 0.357 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.400801e-01 | 0.356 |
| R-HSA-912446 | Meiotic recombination | 4.400801e-01 | 0.356 |
| R-HSA-163685 | Integration of energy metabolism | 4.433799e-01 | 0.353 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.455672e-01 | 0.351 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.510009e-01 | 0.346 |
| R-HSA-1221632 | Meiotic synapsis | 4.510009e-01 | 0.346 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.510009e-01 | 0.346 |
| R-HSA-168249 | Innate Immune System | 4.551160e-01 | 0.342 |
| R-HSA-1632852 | Macroautophagy | 4.597487e-01 | 0.337 |
| R-HSA-5578775 | Ion homeostasis | 4.669866e-01 | 0.331 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.669866e-01 | 0.331 |
| R-HSA-157118 | Signaling by NOTCH | 4.703583e-01 | 0.328 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.722117e-01 | 0.326 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.722117e-01 | 0.326 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.773859e-01 | 0.321 |
| R-HSA-8979227 | Triglyceride metabolism | 4.825097e-01 | 0.316 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.825097e-01 | 0.316 |
| R-HSA-597592 | Post-translational protein modification | 4.845336e-01 | 0.315 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.875835e-01 | 0.312 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.875835e-01 | 0.312 |
| R-HSA-112043 | PLC beta mediated events | 4.926080e-01 | 0.307 |
| R-HSA-1442490 | Collagen degradation | 4.926080e-01 | 0.307 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.975834e-01 | 0.303 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.975834e-01 | 0.303 |
| R-HSA-186797 | Signaling by PDGF | 4.975834e-01 | 0.303 |
| R-HSA-373755 | Semaphorin interactions | 5.025104e-01 | 0.299 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.040574e-01 | 0.298 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.073894e-01 | 0.295 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.098459e-01 | 0.293 |
| R-HSA-9612973 | Autophagy | 5.101953e-01 | 0.292 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.122208e-01 | 0.291 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.124135e-01 | 0.290 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.173184e-01 | 0.286 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.217429e-01 | 0.283 |
| R-HSA-112040 | G-protein mediated events | 5.217429e-01 | 0.283 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.223223e-01 | 0.282 |
| R-HSA-162582 | Signal Transduction | 5.253050e-01 | 0.280 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.264344e-01 | 0.279 |
| R-HSA-167172 | Transcription of the HIV genome | 5.264344e-01 | 0.279 |
| R-HSA-5218859 | Regulated Necrosis | 5.264344e-01 | 0.279 |
| R-HSA-109581 | Apoptosis | 5.283106e-01 | 0.277 |
| R-HSA-3000178 | ECM proteoglycans | 5.402363e-01 | 0.267 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.402363e-01 | 0.267 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.402363e-01 | 0.267 |
| R-HSA-9675108 | Nervous system development | 5.436755e-01 | 0.265 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.447476e-01 | 0.264 |
| R-HSA-74259 | Purine catabolism | 5.447476e-01 | 0.264 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.536385e-01 | 0.257 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.546278e-01 | 0.256 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.603346e-01 | 0.252 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.623568e-01 | 0.250 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.631685e-01 | 0.249 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.631685e-01 | 0.249 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.666524e-01 | 0.247 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.709060e-01 | 0.243 |
| R-HSA-216083 | Integrin cell surface interactions | 5.709060e-01 | 0.243 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.792892e-01 | 0.237 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.792892e-01 | 0.237 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.907905e-01 | 0.229 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.955703e-01 | 0.225 |
| R-HSA-1500620 | Meiosis | 5.995418e-01 | 0.222 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.041105e-01 | 0.219 |
| R-HSA-449147 | Signaling by Interleukins | 6.111825e-01 | 0.214 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.112253e-01 | 0.214 |
| R-HSA-9663891 | Selective autophagy | 6.150440e-01 | 0.211 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.150440e-01 | 0.211 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.188254e-01 | 0.208 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.196621e-01 | 0.208 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.225700e-01 | 0.206 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.247412e-01 | 0.204 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.335856e-01 | 0.198 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.335856e-01 | 0.198 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.347430e-01 | 0.197 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.442818e-01 | 0.191 |
| R-HSA-72172 | mRNA Splicing | 6.469527e-01 | 0.189 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.512396e-01 | 0.186 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.512396e-01 | 0.186 |
| R-HSA-157579 | Telomere Maintenance | 6.546676e-01 | 0.184 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.546676e-01 | 0.184 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.580621e-01 | 0.182 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.614235e-01 | 0.180 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.713119e-01 | 0.173 |
| R-HSA-1483255 | PI Metabolism | 6.713119e-01 | 0.173 |
| R-HSA-1474244 | Extracellular matrix organization | 6.716755e-01 | 0.173 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.745438e-01 | 0.171 |
| R-HSA-111885 | Opioid Signalling | 6.777442e-01 | 0.169 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.777442e-01 | 0.169 |
| R-HSA-418990 | Adherens junctions interactions | 6.794315e-01 | 0.168 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.840514e-01 | 0.165 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.871588e-01 | 0.163 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.902359e-01 | 0.161 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.902359e-01 | 0.161 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.902359e-01 | 0.161 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.918322e-01 | 0.160 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.932829e-01 | 0.159 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.932829e-01 | 0.159 |
| R-HSA-5419276 | Mitochondrial translation termination | 6.963001e-01 | 0.157 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.963001e-01 | 0.157 |
| R-HSA-162906 | HIV Infection | 6.990061e-01 | 0.156 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.992878e-01 | 0.155 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.992878e-01 | 0.155 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.992878e-01 | 0.155 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.053089e-01 | 0.152 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.080768e-01 | 0.150 |
| R-HSA-72312 | rRNA processing | 7.094499e-01 | 0.149 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.166106e-01 | 0.145 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.166106e-01 | 0.145 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.183596e-01 | 0.144 |
| R-HSA-373760 | L1CAM interactions | 7.221615e-01 | 0.141 |
| R-HSA-73894 | DNA Repair | 7.228019e-01 | 0.141 |
| R-HSA-168256 | Immune System | 7.242625e-01 | 0.140 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.276044e-01 | 0.138 |
| R-HSA-68875 | Mitotic Prophase | 7.329414e-01 | 0.135 |
| R-HSA-8953854 | Metabolism of RNA | 7.400820e-01 | 0.131 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.407526e-01 | 0.130 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.433055e-01 | 0.129 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.433055e-01 | 0.129 |
| R-HSA-421270 | Cell-cell junction organization | 7.464215e-01 | 0.127 |
| R-HSA-8956319 | Nucleotide catabolism | 7.581070e-01 | 0.120 |
| R-HSA-1474165 | Reproduction | 7.628498e-01 | 0.118 |
| R-HSA-9843745 | Adipogenesis | 7.651865e-01 | 0.116 |
| R-HSA-9909396 | Circadian clock | 7.675003e-01 | 0.115 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.742939e-01 | 0.111 |
| R-HSA-212436 | Generic Transcription Pathway | 7.801185e-01 | 0.108 |
| R-HSA-5368287 | Mitochondrial translation | 7.830745e-01 | 0.106 |
| R-HSA-6807070 | PTEN Regulation | 7.852131e-01 | 0.105 |
| R-HSA-446728 | Cell junction organization | 7.920122e-01 | 0.101 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.935540e-01 | 0.100 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.935599e-01 | 0.100 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.054796e-01 | 0.094 |
| R-HSA-422475 | Axon guidance | 8.093205e-01 | 0.092 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.111804e-01 | 0.091 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.168909e-01 | 0.088 |
| R-HSA-195721 | Signaling by WNT | 8.209965e-01 | 0.086 |
| R-HSA-162587 | HIV Life Cycle | 8.220886e-01 | 0.085 |
| R-HSA-9711097 | Cellular response to starvation | 8.238448e-01 | 0.084 |
| R-HSA-877300 | Interferon gamma signaling | 8.255837e-01 | 0.083 |
| R-HSA-74160 | Gene expression (Transcription) | 8.346346e-01 | 0.079 |
| R-HSA-1500931 | Cell-Cell communication | 8.439493e-01 | 0.074 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.497108e-01 | 0.071 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.497108e-01 | 0.071 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.521352e-01 | 0.069 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.526663e-01 | 0.069 |
| R-HSA-168255 | Influenza Infection | 8.584053e-01 | 0.066 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.714286e-01 | 0.060 |
| R-HSA-983712 | Ion channel transport | 8.717992e-01 | 0.060 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.743229e-01 | 0.058 |
| R-HSA-9609690 | HCMV Early Events | 8.804182e-01 | 0.055 |
| R-HSA-1266738 | Developmental Biology | 8.814988e-01 | 0.055 |
| R-HSA-392499 | Metabolism of proteins | 8.850231e-01 | 0.053 |
| R-HSA-428157 | Sphingolipid metabolism | 8.862196e-01 | 0.052 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.927295e-01 | 0.049 |
| R-HSA-6805567 | Keratinization | 8.928133e-01 | 0.049 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.990271e-01 | 0.046 |
| R-HSA-9748784 | Drug ADME | 9.048829e-01 | 0.043 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.121688e-01 | 0.040 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.135597e-01 | 0.039 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.183092e-01 | 0.037 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.188999e-01 | 0.037 |
| R-HSA-5663205 | Infectious disease | 9.198879e-01 | 0.036 |
| R-HSA-15869 | Metabolism of nucleotides | 9.205010e-01 | 0.036 |
| R-HSA-4839726 | Chromatin organization | 9.301691e-01 | 0.031 |
| R-HSA-9609646 | HCMV Infection | 9.308624e-01 | 0.031 |
| R-HSA-72766 | Translation | 9.370737e-01 | 0.028 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.422357e-01 | 0.026 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.477294e-01 | 0.023 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.492482e-01 | 0.023 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.531743e-01 | 0.021 |
| R-HSA-1483257 | Phospholipid metabolism | 9.559028e-01 | 0.020 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.563419e-01 | 0.019 |
| R-HSA-556833 | Metabolism of lipids | 9.653245e-01 | 0.015 |
| R-HSA-9824446 | Viral Infection Pathways | 9.722559e-01 | 0.012 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.738161e-01 | 0.012 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.743367e-01 | 0.011 |
| R-HSA-9679506 | SARS-CoV Infections | 9.782747e-01 | 0.010 |
| R-HSA-1643685 | Disease | 9.802912e-01 | 0.009 |
| R-HSA-1280218 | Adaptive Immune System | 9.814536e-01 | 0.008 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.819490e-01 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 9.858251e-01 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 9.858251e-01 | 0.006 |
| R-HSA-5668914 | Diseases of metabolism | 9.884146e-01 | 0.005 |
| R-HSA-211859 | Biological oxidations | 9.956164e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.974191e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.996644e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.997289e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.998578e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999846e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.833 | 0.185 | 2 | 0.837 |
CDC7 |
0.830 | 0.204 | 1 | 0.620 |
BMPR1B |
0.824 | 0.380 | 1 | 0.698 |
GCN2 |
0.818 | -0.046 | 2 | 0.799 |
DSTYK |
0.817 | 0.076 | 2 | 0.829 |
IKKB |
0.816 | -0.014 | -2 | 0.716 |
GRK6 |
0.816 | 0.219 | 1 | 0.623 |
CLK3 |
0.814 | 0.080 | 1 | 0.500 |
MTOR |
0.814 | -0.051 | 1 | 0.471 |
PRPK |
0.812 | -0.049 | -1 | 0.859 |
RAF1 |
0.812 | -0.015 | 1 | 0.547 |
NEK6 |
0.811 | 0.016 | -2 | 0.828 |
NLK |
0.810 | -0.005 | 1 | 0.488 |
GRK5 |
0.810 | 0.106 | -3 | 0.902 |
TBK1 |
0.810 | -0.092 | 1 | 0.449 |
MOS |
0.810 | 0.046 | 1 | 0.571 |
ULK2 |
0.810 | -0.081 | 2 | 0.789 |
BMPR1A |
0.810 | 0.314 | 1 | 0.673 |
NEK7 |
0.809 | -0.020 | -3 | 0.884 |
ATR |
0.809 | -0.024 | 1 | 0.517 |
ACVR2A |
0.809 | 0.283 | -2 | 0.758 |
BMPR2 |
0.808 | 0.009 | -2 | 0.844 |
TGFBR2 |
0.808 | 0.056 | -2 | 0.770 |
TGFBR1 |
0.808 | 0.230 | -2 | 0.784 |
GRK1 |
0.808 | 0.129 | -2 | 0.731 |
CAMK2G |
0.808 | -0.003 | 2 | 0.749 |
ALK4 |
0.807 | 0.217 | -2 | 0.809 |
IKKE |
0.807 | -0.097 | 1 | 0.443 |
PIM3 |
0.807 | 0.018 | -3 | 0.834 |
ERK5 |
0.807 | -0.017 | 1 | 0.444 |
RSK2 |
0.807 | 0.068 | -3 | 0.765 |
IKKA |
0.807 | 0.054 | -2 | 0.707 |
PDHK4 |
0.807 | -0.145 | 1 | 0.528 |
CAMK1B |
0.806 | -0.003 | -3 | 0.880 |
PLK1 |
0.805 | 0.172 | -2 | 0.767 |
ACVR2B |
0.805 | 0.271 | -2 | 0.763 |
MLK1 |
0.805 | -0.025 | 2 | 0.807 |
NDR2 |
0.804 | 0.012 | -3 | 0.837 |
ULK1 |
0.804 | -0.060 | -3 | 0.863 |
WNK1 |
0.804 | -0.035 | -2 | 0.843 |
RIPK3 |
0.803 | -0.042 | 3 | 0.633 |
SKMLCK |
0.803 | 0.072 | -2 | 0.813 |
MAPKAPK2 |
0.802 | 0.047 | -3 | 0.722 |
PRKD1 |
0.802 | 0.000 | -3 | 0.828 |
PDHK1 |
0.802 | -0.165 | 1 | 0.493 |
HUNK |
0.801 | -0.023 | 2 | 0.810 |
GRK4 |
0.801 | 0.036 | -2 | 0.755 |
GRK7 |
0.801 | 0.131 | 1 | 0.553 |
GRK2 |
0.801 | 0.241 | -2 | 0.652 |
KIS |
0.801 | -0.023 | 1 | 0.361 |
CDKL1 |
0.800 | -0.020 | -3 | 0.807 |
DRAK1 |
0.800 | 0.285 | 1 | 0.710 |
MST4 |
0.800 | -0.016 | 2 | 0.825 |
DAPK2 |
0.799 | 0.068 | -3 | 0.885 |
CDK1 |
0.799 | 0.019 | 1 | 0.382 |
CDK8 |
0.799 | -0.033 | 1 | 0.358 |
PKN3 |
0.799 | -0.036 | -3 | 0.839 |
CHAK2 |
0.799 | -0.042 | -1 | 0.838 |
NIK |
0.799 | -0.051 | -3 | 0.903 |
DLK |
0.799 | 0.067 | 1 | 0.564 |
NEK9 |
0.798 | -0.075 | 2 | 0.834 |
ALK2 |
0.798 | 0.173 | -2 | 0.792 |
P90RSK |
0.798 | 0.018 | -3 | 0.767 |
BCKDK |
0.798 | -0.098 | -1 | 0.830 |
MAPKAPK3 |
0.798 | -0.012 | -3 | 0.779 |
PKN2 |
0.798 | -0.013 | -3 | 0.858 |
PRKD2 |
0.797 | -0.000 | -3 | 0.766 |
CAMLCK |
0.797 | -0.008 | -2 | 0.808 |
LATS2 |
0.796 | -0.007 | -5 | 0.703 |
MLK3 |
0.796 | 0.010 | 2 | 0.730 |
NDR1 |
0.796 | -0.035 | -3 | 0.837 |
CAMK2B |
0.796 | 0.064 | 2 | 0.706 |
NUAK2 |
0.796 | -0.024 | -3 | 0.851 |
PKCD |
0.795 | -0.013 | 2 | 0.773 |
CAMK2D |
0.795 | -0.031 | -3 | 0.862 |
ANKRD3 |
0.795 | -0.047 | 1 | 0.540 |
WNK3 |
0.795 | -0.164 | 1 | 0.493 |
ATM |
0.795 | -0.033 | 1 | 0.490 |
HIPK4 |
0.795 | -0.038 | 1 | 0.437 |
JNK2 |
0.794 | 0.004 | 1 | 0.342 |
TSSK2 |
0.794 | -0.002 | -5 | 0.785 |
CDK19 |
0.793 | -0.036 | 1 | 0.333 |
CK2A2 |
0.793 | 0.191 | 1 | 0.621 |
RSK3 |
0.793 | -0.015 | -3 | 0.761 |
PIM1 |
0.793 | 0.001 | -3 | 0.784 |
CDK2 |
0.792 | 0.011 | 1 | 0.446 |
SRPK1 |
0.792 | -0.016 | -3 | 0.747 |
MLK4 |
0.792 | 0.030 | 2 | 0.728 |
PKR |
0.792 | -0.007 | 1 | 0.516 |
CDKL5 |
0.792 | -0.042 | -3 | 0.796 |
IRE1 |
0.791 | -0.091 | 1 | 0.481 |
P70S6KB |
0.791 | -0.013 | -3 | 0.799 |
JNK3 |
0.791 | -0.012 | 1 | 0.356 |
ICK |
0.791 | -0.033 | -3 | 0.846 |
AURC |
0.790 | 0.035 | -2 | 0.623 |
CDK13 |
0.790 | -0.043 | 1 | 0.351 |
TTBK2 |
0.790 | -0.131 | 2 | 0.700 |
MEK1 |
0.790 | 0.038 | 2 | 0.827 |
TSSK1 |
0.790 | -0.020 | -3 | 0.875 |
MARK4 |
0.790 | -0.073 | 4 | 0.815 |
DYRK2 |
0.790 | -0.034 | 1 | 0.375 |
P38G |
0.789 | -0.012 | 1 | 0.299 |
RSK4 |
0.789 | 0.064 | -3 | 0.725 |
CDK18 |
0.789 | -0.024 | 1 | 0.328 |
PLK3 |
0.789 | 0.001 | 2 | 0.717 |
CAMK4 |
0.789 | -0.061 | -3 | 0.839 |
RIPK1 |
0.789 | -0.136 | 1 | 0.526 |
MLK2 |
0.789 | -0.117 | 2 | 0.810 |
TLK2 |
0.789 | -0.007 | 1 | 0.486 |
P38A |
0.789 | -0.019 | 1 | 0.373 |
GRK3 |
0.788 | 0.191 | -2 | 0.606 |
MASTL |
0.788 | -0.174 | -2 | 0.777 |
AMPKA1 |
0.788 | -0.074 | -3 | 0.864 |
SMG1 |
0.788 | -0.051 | 1 | 0.472 |
P38B |
0.788 | -0.012 | 1 | 0.327 |
CAMK2A |
0.788 | 0.041 | 2 | 0.717 |
PKACG |
0.788 | -0.037 | -2 | 0.683 |
FAM20C |
0.787 | -0.021 | 2 | 0.502 |
ERK1 |
0.787 | -0.026 | 1 | 0.319 |
CDK5 |
0.787 | -0.022 | 1 | 0.387 |
P38D |
0.787 | -0.003 | 1 | 0.281 |
YSK4 |
0.786 | -0.069 | 1 | 0.491 |
AURA |
0.786 | 0.046 | -2 | 0.595 |
CDK3 |
0.786 | 0.003 | 1 | 0.319 |
NEK2 |
0.786 | -0.091 | 2 | 0.803 |
NIM1 |
0.786 | -0.098 | 3 | 0.642 |
PAK1 |
0.785 | -0.035 | -2 | 0.734 |
CDK17 |
0.785 | -0.033 | 1 | 0.308 |
CK2A1 |
0.785 | 0.189 | 1 | 0.629 |
PAK6 |
0.785 | 0.001 | -2 | 0.687 |
CLK4 |
0.784 | 0.001 | -3 | 0.769 |
MSK2 |
0.784 | -0.025 | -3 | 0.746 |
SRPK2 |
0.784 | -0.019 | -3 | 0.666 |
IRE2 |
0.784 | -0.095 | 2 | 0.765 |
ERK2 |
0.783 | -0.042 | 1 | 0.363 |
DNAPK |
0.783 | -0.057 | 1 | 0.419 |
PKCG |
0.783 | -0.033 | 2 | 0.721 |
MNK2 |
0.783 | -0.042 | -2 | 0.755 |
CLK1 |
0.783 | 0.001 | -3 | 0.749 |
PKCA |
0.782 | -0.034 | 2 | 0.722 |
PKCB |
0.782 | -0.032 | 2 | 0.729 |
SRPK3 |
0.782 | -0.025 | -3 | 0.724 |
PAK3 |
0.782 | -0.082 | -2 | 0.735 |
AURB |
0.782 | 0.007 | -2 | 0.619 |
CDK12 |
0.782 | -0.049 | 1 | 0.333 |
MSK1 |
0.782 | 0.022 | -3 | 0.748 |
VRK2 |
0.782 | -0.142 | 1 | 0.516 |
CDK7 |
0.781 | -0.074 | 1 | 0.372 |
LATS1 |
0.781 | 0.004 | -3 | 0.841 |
MELK |
0.781 | -0.072 | -3 | 0.810 |
PRKD3 |
0.781 | -0.042 | -3 | 0.749 |
CLK2 |
0.781 | 0.054 | -3 | 0.740 |
BRAF |
0.781 | 0.007 | -4 | 0.795 |
PKCH |
0.781 | -0.047 | 2 | 0.728 |
PERK |
0.781 | -0.086 | -2 | 0.802 |
MYLK4 |
0.781 | 0.016 | -2 | 0.719 |
PASK |
0.780 | 0.148 | -3 | 0.861 |
CHAK1 |
0.779 | -0.127 | 2 | 0.748 |
HIPK2 |
0.779 | -0.024 | 1 | 0.317 |
NUAK1 |
0.779 | -0.071 | -3 | 0.792 |
AMPKA2 |
0.779 | -0.086 | -3 | 0.824 |
MEKK3 |
0.779 | -0.039 | 1 | 0.526 |
PKACB |
0.778 | 0.014 | -2 | 0.629 |
PINK1 |
0.778 | -0.089 | 1 | 0.474 |
PRP4 |
0.778 | -0.001 | -3 | 0.793 |
PAK2 |
0.778 | -0.064 | -2 | 0.724 |
ZAK |
0.778 | -0.060 | 1 | 0.495 |
QIK |
0.777 | -0.109 | -3 | 0.861 |
PHKG1 |
0.777 | -0.108 | -3 | 0.836 |
CK1E |
0.777 | 0.043 | -3 | 0.629 |
HRI |
0.776 | -0.144 | -2 | 0.805 |
CDK16 |
0.776 | -0.020 | 1 | 0.311 |
SGK3 |
0.776 | -0.026 | -3 | 0.768 |
PKCZ |
0.776 | -0.087 | 2 | 0.770 |
CHK1 |
0.776 | -0.044 | -3 | 0.821 |
PLK4 |
0.776 | -0.103 | 2 | 0.660 |
CAMKK1 |
0.776 | 0.001 | -2 | 0.771 |
CDK9 |
0.775 | -0.081 | 1 | 0.355 |
PKG2 |
0.775 | -0.023 | -2 | 0.626 |
MST3 |
0.775 | 0.015 | 2 | 0.811 |
CDK14 |
0.775 | -0.034 | 1 | 0.366 |
BRSK1 |
0.775 | -0.029 | -3 | 0.797 |
QSK |
0.775 | -0.060 | 4 | 0.789 |
WNK4 |
0.775 | -0.093 | -2 | 0.848 |
JNK1 |
0.774 | -0.011 | 1 | 0.347 |
MNK1 |
0.774 | -0.050 | -2 | 0.753 |
NEK5 |
0.774 | -0.076 | 1 | 0.507 |
HIPK1 |
0.774 | -0.039 | 1 | 0.385 |
MAPKAPK5 |
0.774 | -0.094 | -3 | 0.728 |
TAO3 |
0.774 | 0.004 | 1 | 0.504 |
PRKX |
0.774 | 0.036 | -3 | 0.667 |
MEKK2 |
0.773 | -0.071 | 2 | 0.808 |
TLK1 |
0.773 | -0.100 | -2 | 0.773 |
MARK2 |
0.773 | -0.037 | 4 | 0.712 |
MARK3 |
0.773 | -0.028 | 4 | 0.743 |
MEKK1 |
0.773 | -0.127 | 1 | 0.485 |
MEK5 |
0.773 | -0.140 | 2 | 0.817 |
DYRK4 |
0.772 | -0.038 | 1 | 0.332 |
AKT2 |
0.772 | -0.017 | -3 | 0.685 |
CAMK1G |
0.772 | -0.056 | -3 | 0.770 |
DCAMKL1 |
0.772 | -0.043 | -3 | 0.784 |
DYRK1A |
0.772 | -0.049 | 1 | 0.399 |
PIM2 |
0.772 | -0.024 | -3 | 0.746 |
NEK8 |
0.771 | -0.056 | 2 | 0.807 |
GAK |
0.771 | 0.030 | 1 | 0.535 |
IRAK4 |
0.771 | -0.129 | 1 | 0.478 |
SIK |
0.771 | -0.082 | -3 | 0.768 |
SMMLCK |
0.770 | -0.006 | -3 | 0.834 |
BRSK2 |
0.770 | -0.111 | -3 | 0.832 |
MARK1 |
0.769 | -0.043 | 4 | 0.771 |
PHKG2 |
0.769 | -0.090 | -3 | 0.813 |
HIPK3 |
0.768 | -0.070 | 1 | 0.363 |
MPSK1 |
0.768 | -0.060 | 1 | 0.449 |
SNRK |
0.768 | -0.172 | 2 | 0.698 |
PLK2 |
0.768 | 0.033 | -3 | 0.815 |
DCAMKL2 |
0.768 | -0.055 | -3 | 0.813 |
TTBK1 |
0.768 | -0.137 | 2 | 0.612 |
CK1D |
0.767 | 0.034 | -3 | 0.586 |
CAMKK2 |
0.767 | -0.039 | -2 | 0.767 |
DYRK1B |
0.766 | -0.052 | 1 | 0.363 |
P70S6K |
0.766 | -0.045 | -3 | 0.709 |
CDK10 |
0.766 | -0.039 | 1 | 0.361 |
CK1G1 |
0.766 | -0.029 | -3 | 0.614 |
GCK |
0.766 | 0.050 | 1 | 0.550 |
CK1A2 |
0.765 | 0.038 | -3 | 0.583 |
PKCT |
0.765 | -0.081 | 2 | 0.736 |
TAK1 |
0.765 | 0.005 | 1 | 0.529 |
AKT1 |
0.765 | -0.023 | -3 | 0.704 |
DAPK3 |
0.764 | 0.039 | -3 | 0.805 |
CDK6 |
0.764 | -0.040 | 1 | 0.336 |
DYRK3 |
0.764 | -0.049 | 1 | 0.381 |
PKACA |
0.764 | -0.007 | -2 | 0.582 |
DAPK1 |
0.764 | 0.079 | -3 | 0.791 |
PKCI |
0.763 | -0.062 | 2 | 0.742 |
EEF2K |
0.763 | -0.029 | 3 | 0.749 |
TAO2 |
0.763 | -0.084 | 2 | 0.819 |
MST2 |
0.762 | -0.024 | 1 | 0.524 |
PAK5 |
0.762 | -0.047 | -2 | 0.618 |
LKB1 |
0.762 | -0.077 | -3 | 0.879 |
ERK7 |
0.762 | -0.030 | 2 | 0.529 |
NEK11 |
0.762 | -0.113 | 1 | 0.521 |
PDK1 |
0.761 | -0.094 | 1 | 0.491 |
MINK |
0.761 | -0.046 | 1 | 0.497 |
GSK3B |
0.761 | -0.030 | 4 | 0.368 |
IRAK1 |
0.761 | -0.180 | -1 | 0.786 |
GSK3A |
0.760 | -0.016 | 4 | 0.379 |
SSTK |
0.760 | -0.088 | 4 | 0.783 |
CAMK1D |
0.760 | -0.037 | -3 | 0.688 |
TNIK |
0.760 | -0.033 | 3 | 0.772 |
NEK4 |
0.760 | -0.130 | 1 | 0.479 |
CDK4 |
0.760 | -0.050 | 1 | 0.322 |
VRK1 |
0.759 | -0.037 | 2 | 0.836 |
HPK1 |
0.759 | 0.004 | 1 | 0.536 |
HGK |
0.758 | -0.075 | 3 | 0.764 |
PKCE |
0.758 | -0.032 | 2 | 0.711 |
PAK4 |
0.757 | -0.043 | -2 | 0.625 |
NEK1 |
0.756 | -0.107 | 1 | 0.488 |
MEKK6 |
0.755 | -0.124 | 1 | 0.473 |
MAP3K15 |
0.755 | -0.122 | 1 | 0.466 |
BUB1 |
0.755 | 0.012 | -5 | 0.743 |
CHK2 |
0.754 | -0.027 | -3 | 0.634 |
STK33 |
0.753 | -0.113 | 2 | 0.601 |
MST1 |
0.753 | -0.073 | 1 | 0.502 |
LRRK2 |
0.753 | -0.131 | 2 | 0.822 |
KHS2 |
0.753 | 0.002 | 1 | 0.511 |
MEK2 |
0.752 | -0.119 | 2 | 0.818 |
PKN1 |
0.752 | -0.073 | -3 | 0.732 |
LOK |
0.752 | -0.101 | -2 | 0.729 |
SLK |
0.751 | -0.070 | -2 | 0.669 |
OSR1 |
0.750 | 0.020 | 2 | 0.803 |
RIPK2 |
0.750 | -0.179 | 1 | 0.461 |
KHS1 |
0.750 | -0.055 | 1 | 0.480 |
YSK1 |
0.749 | -0.096 | 2 | 0.802 |
MRCKA |
0.749 | -0.036 | -3 | 0.759 |
MAK |
0.749 | -0.016 | -2 | 0.719 |
AKT3 |
0.749 | -0.025 | -3 | 0.615 |
SGK1 |
0.748 | -0.019 | -3 | 0.598 |
PBK |
0.746 | -0.074 | 1 | 0.445 |
CAMK1A |
0.746 | -0.050 | -3 | 0.653 |
ROCK2 |
0.746 | -0.036 | -3 | 0.791 |
MRCKB |
0.745 | -0.048 | -3 | 0.743 |
PDHK3_TYR |
0.744 | 0.137 | 4 | 0.887 |
MOK |
0.744 | -0.046 | 1 | 0.383 |
TTK |
0.744 | -0.022 | -2 | 0.776 |
NEK3 |
0.742 | -0.154 | 1 | 0.425 |
HASPIN |
0.740 | -0.023 | -1 | 0.728 |
MYO3B |
0.740 | -0.061 | 2 | 0.802 |
CK1A |
0.739 | 0.065 | -3 | 0.493 |
BIKE |
0.739 | -0.041 | 1 | 0.438 |
DMPK1 |
0.737 | -0.021 | -3 | 0.764 |
PDHK4_TYR |
0.737 | 0.084 | 2 | 0.820 |
PDHK1_TYR |
0.736 | 0.086 | -1 | 0.881 |
MYO3A |
0.736 | -0.076 | 1 | 0.484 |
BMPR2_TYR |
0.736 | 0.124 | -1 | 0.826 |
MAP2K6_TYR |
0.735 | 0.085 | -1 | 0.860 |
YANK3 |
0.735 | -0.040 | 2 | 0.363 |
TXK |
0.735 | 0.272 | 1 | 0.648 |
PKG1 |
0.735 | -0.072 | -2 | 0.549 |
ASK1 |
0.735 | -0.130 | 1 | 0.458 |
MAP2K4_TYR |
0.734 | -0.013 | -1 | 0.869 |
TAO1 |
0.733 | -0.108 | 1 | 0.428 |
TESK1_TYR |
0.732 | -0.090 | 3 | 0.777 |
PINK1_TYR |
0.732 | -0.077 | 1 | 0.527 |
ROCK1 |
0.732 | -0.055 | -3 | 0.757 |
SBK |
0.732 | -0.059 | -3 | 0.557 |
ALPHAK3 |
0.731 | -0.070 | -1 | 0.761 |
MAP2K7_TYR |
0.731 | -0.171 | 2 | 0.821 |
STLK3 |
0.729 | -0.093 | 1 | 0.465 |
PKMYT1_TYR |
0.729 | -0.119 | 3 | 0.743 |
CRIK |
0.729 | -0.048 | -3 | 0.698 |
EPHA6 |
0.726 | 0.001 | -1 | 0.848 |
EPHB4 |
0.724 | 0.018 | -1 | 0.851 |
LIMK2_TYR |
0.724 | -0.121 | -3 | 0.913 |
ABL2 |
0.724 | 0.000 | -1 | 0.857 |
FER |
0.723 | 0.026 | 1 | 0.570 |
AAK1 |
0.723 | -0.024 | 1 | 0.359 |
SRMS |
0.723 | 0.105 | 1 | 0.599 |
FGR |
0.723 | 0.005 | 1 | 0.555 |
YES1 |
0.722 | 0.012 | -1 | 0.872 |
TYRO3 |
0.721 | -0.067 | 3 | 0.656 |
CSF1R |
0.721 | -0.074 | 3 | 0.655 |
RET |
0.721 | -0.176 | 1 | 0.468 |
EPHA4 |
0.721 | 0.030 | 2 | 0.702 |
ABL1 |
0.721 | -0.016 | -1 | 0.857 |
TEC |
0.720 | 0.089 | -1 | 0.805 |
EPHB1 |
0.720 | 0.059 | 1 | 0.574 |
MST1R |
0.719 | -0.167 | 3 | 0.687 |
TYK2 |
0.719 | -0.231 | 1 | 0.457 |
ITK |
0.718 | 0.082 | -1 | 0.817 |
ROS1 |
0.717 | -0.119 | 3 | 0.614 |
MERTK |
0.717 | 0.063 | 3 | 0.637 |
LIMK1_TYR |
0.717 | -0.213 | 2 | 0.825 |
CK1G3 |
0.717 | -0.006 | -3 | 0.445 |
INSRR |
0.717 | 0.003 | 3 | 0.599 |
HCK |
0.716 | -0.035 | -1 | 0.835 |
EPHB2 |
0.716 | 0.031 | -1 | 0.838 |
DDR1 |
0.716 | -0.156 | 4 | 0.817 |
PTK2B |
0.715 | 0.162 | -1 | 0.846 |
JAK2 |
0.715 | -0.209 | 1 | 0.449 |
KIT |
0.714 | -0.073 | 3 | 0.666 |
EPHB3 |
0.714 | -0.012 | -1 | 0.843 |
BMX |
0.714 | 0.067 | -1 | 0.746 |
WEE1_TYR |
0.714 | -0.035 | -1 | 0.780 |
BLK |
0.713 | -0.003 | -1 | 0.843 |
LCK |
0.713 | -0.026 | -1 | 0.830 |
PDGFRB |
0.713 | -0.117 | 3 | 0.667 |
FYN |
0.711 | 0.040 | -1 | 0.797 |
TNK2 |
0.711 | -0.103 | 3 | 0.637 |
JAK3 |
0.711 | -0.147 | 1 | 0.474 |
AXL |
0.711 | -0.050 | 3 | 0.643 |
NEK10_TYR |
0.711 | -0.151 | 1 | 0.390 |
FLT3 |
0.711 | -0.138 | 3 | 0.653 |
BTK |
0.711 | -0.060 | -1 | 0.809 |
EPHA7 |
0.710 | 0.008 | 2 | 0.714 |
NTRK1 |
0.709 | -0.049 | -1 | 0.841 |
FRK |
0.708 | -0.035 | -1 | 0.865 |
JAK1 |
0.708 | -0.134 | 1 | 0.430 |
PTK6 |
0.708 | -0.101 | -1 | 0.770 |
FGFR2 |
0.707 | -0.153 | 3 | 0.677 |
MET |
0.707 | -0.065 | 3 | 0.655 |
KDR |
0.706 | -0.134 | 3 | 0.623 |
EPHA3 |
0.706 | -0.045 | 2 | 0.689 |
TNK1 |
0.705 | -0.158 | 3 | 0.634 |
PTK2 |
0.705 | 0.128 | -1 | 0.701 |
ERBB2 |
0.705 | -0.103 | 1 | 0.489 |
ALK |
0.705 | -0.076 | 3 | 0.559 |
PDGFRA |
0.705 | -0.203 | 3 | 0.664 |
LTK |
0.704 | -0.095 | 3 | 0.597 |
FLT1 |
0.704 | -0.093 | -1 | 0.808 |
NTRK2 |
0.704 | -0.089 | 3 | 0.620 |
TNNI3K_TYR |
0.704 | -0.158 | 1 | 0.439 |
YANK2 |
0.704 | -0.054 | 2 | 0.379 |
SYK |
0.703 | 0.081 | -1 | 0.721 |
EPHA5 |
0.703 | 0.006 | 2 | 0.690 |
SRC |
0.703 | -0.001 | -1 | 0.821 |
EGFR |
0.702 | -0.048 | 1 | 0.439 |
NTRK3 |
0.702 | -0.040 | -1 | 0.794 |
MATK |
0.701 | -0.042 | -1 | 0.794 |
LYN |
0.701 | -0.061 | 3 | 0.585 |
EPHA1 |
0.701 | -0.089 | 3 | 0.632 |
FGFR1 |
0.700 | -0.197 | 3 | 0.626 |
TEK |
0.700 | -0.175 | 3 | 0.584 |
EPHA8 |
0.700 | -0.007 | -1 | 0.807 |
CSK |
0.699 | -0.066 | 2 | 0.729 |
FLT4 |
0.699 | -0.156 | 3 | 0.626 |
FGFR3 |
0.698 | -0.130 | 3 | 0.648 |
INSR |
0.698 | -0.088 | 3 | 0.582 |
FGFR4 |
0.695 | -0.072 | -1 | 0.789 |
MUSK |
0.694 | -0.087 | 1 | 0.424 |
CK1G2 |
0.693 | -0.014 | -3 | 0.538 |
EPHA2 |
0.691 | -0.009 | -1 | 0.760 |
ERBB4 |
0.690 | -0.021 | 1 | 0.499 |
DDR2 |
0.690 | -0.120 | 3 | 0.602 |
IGF1R |
0.689 | -0.041 | 3 | 0.519 |
FES |
0.687 | 0.053 | -1 | 0.737 |
ZAP70 |
0.671 | -0.036 | -1 | 0.649 |