Motif 742 (n=143)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0C4DFX4 | None | S330 | ochoa | Snf2 related CREBBP activator protein | None |
A0A0J9YVX5 | None | S175 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) | None |
A0A1W2PPC1 | PRR33 | S311 | ochoa | Proline rich 33 | None |
A2RUB6 | CCDC66 | S797 | ochoa | Coiled-coil domain-containing protein 66 | Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Required for the assembly of signaling-competent cilia with proper structure and length (PubMed:36606424). Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex (PubMed:36606424). Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation (PubMed:36606424). Plays two important roles during cell division (PubMed:35849559). First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment (PubMed:35849559). Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs (PubMed:35849559). Plays a role in retina morphogenesis and/or homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6NS45, ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559}. |
A8MZF0 | PRR33 | S163 | ochoa | Proline-rich protein 33 | None |
O00159 | MYO1C | S864 | ochoa | Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}. |
O00472 | ELL2 | S503 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
O14924 | RGS12 | S850 | ochoa | Regulator of G-protein signaling 12 (RGS12) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. {ECO:0000250|UniProtKB:O08774}.; FUNCTION: [Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. {ECO:0000269|PubMed:12024043}. |
O15085 | ARHGEF11 | S1458 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
O43187 | IRAK2 | S144 | ochoa | Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) | Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}. |
O60291 | MGRN1 | S515 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
O60336 | MAPKBP1 | S761 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
O60568 | PLOD3 | S702 | ochoa | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)] | Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812, PubMed:9582318, PubMed:9724729). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity). {ECO:0000250|UniProtKB:Q9R0E1, ECO:0000269|PubMed:10934207, ECO:0000269|PubMed:11896059, ECO:0000269|PubMed:11956192, ECO:0000269|PubMed:12475640, ECO:0000269|PubMed:18298658, ECO:0000269|PubMed:18834968, ECO:0000269|PubMed:25419660, ECO:0000269|PubMed:30089812, ECO:0000269|PubMed:9582318, ECO:0000269|PubMed:9724729, ECO:0000305}. |
O60716 | CTNND1 | S47 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
O60941 | DTNB | S535 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
O75150 | RNF40 | S601 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
O75376 | NCOR1 | S990 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
O75676 | RPS6KA4 | S682 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
O75970 | MPDZ | S354 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
O94811 | TPPP | S160 | ochoa|psp | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) | Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}. |
O95235 | KIF20A | S109 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
O95382 | MAP3K6 | S1149 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
O95613 | PCNT | S2327 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
O96020 | CCNE2 | S383 | ochoa | G1/S-specific cyclin-E2 | Essential for the control of the cell cycle at the late G1 and early S phase. {ECO:0000269|PubMed:9840927, ECO:0000269|PubMed:9840943, ECO:0000269|PubMed:9858585}. |
P05107 | ITGB2 | S350 | ochoa | Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}. |
P07451 | CA3 | S219 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
P11532 | DMD | S3613 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
P13521 | SCG2 | S556 | ochoa | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}. |
P18847 | ATF3 | S59 | ochoa | Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. {ECO:0000269|PubMed:7515060}.; FUNCTION: [Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. {ECO:0000269|PubMed:7515060}.; FUNCTION: [Isoform 3]: Stress-induced isoform, counteracts the transcriptional repression of isoform 1. {ECO:0000269|PubMed:12034827}. |
P23508 | MCC | S294 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
P24534 | EEF1B2 | S175 | ochoa | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
P28290 | ITPRID2 | S650 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
P35568 | IRS1 | S604 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
P35609 | ACTN2 | S596 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
P39880 | CUX1 | S1321 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
P40261 | NNMT | S108 | ochoa | Nicotinamide N-methyltransferase (EC 2.1.1.1) | Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23455543, PubMed:8182091). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:23455543, PubMed:26571212, PubMed:31043742). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909). {ECO:0000250|UniProtKB:O55239, ECO:0000269|PubMed:21823666, ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:26571212, ECO:0000269|PubMed:30044909, ECO:0000269|PubMed:31043742, ECO:0000269|PubMed:8182091}. |
P40818 | USP8 | S434 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
P40855 | PEX19 | S35 | ochoa | Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
P46013 | MKI67 | S2828 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46013 | MKI67 | S3128 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46087 | NOP2 | S675 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
P46939 | UTRN | S1408 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
P49736 | MCM2 | S381 | ochoa | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
P51826 | AFF3 | S755 | ochoa | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. |
P57076 | CFAP298 | S267 | ochoa | Cilia- and flagella-associated protein 298 (Protein kurly homolog) | Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). {ECO:0000250|UniProtKB:Q6DRC3, ECO:0000269|PubMed:24094744}. |
P61964 | WDR5 | S20 | ochoa | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
Q01484 | ANK2 | S2172 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
Q02952 | AKAP12 | S483 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
Q03164 | KMT2A | S1115 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q04637 | EIF4G1 | S1028 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
Q08AE8 | SPIRE1 | S508 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
Q12830 | BPTF | S1382 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
Q12888 | TP53BP1 | S484 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q13015 | MLLT11 | S44 | ochoa | Protein AF1q | Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}. |
Q13133 | NR1H3 | S198 | ochoa|psp | Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (PubMed:37478846). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). {ECO:0000250|UniProtKB:Q9Z0Y9, ECO:0000269|PubMed:19481530, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:37478846}. |
Q14978 | NOLC1 | S291 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
Q15059 | BRD3 | S682 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
Q15326 | ZMYND11 | S447 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
Q17R98 | ZNF827 | S689 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
Q27J81 | INF2 | S351 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
Q2LD37 | BLTP1 | S1682 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
Q2M3G4 | SHROOM1 | S408 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
Q3L8U1 | CHD9 | S2059 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
Q4G163 | FBXO43 | S121 | ochoa | F-box only protein 43 (Endogenous meiotic inhibitor 2) | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}. |
Q5D1E8 | ZC3H12A | S99 | ochoa | Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) | Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:22561375, PubMed:26134560, PubMed:26320658). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q5D1E7, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:19185603, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:22561375, ECO:0000269|PubMed:24048733, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:26134560, ECO:0000269|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269|PubMed:24191027}. |
Q5T0N5 | FNBP1L | S489 | ochoa | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}. |
Q5T4S7 | UBR4 | S1763 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
Q5TF39 | MFSD4B | S496 | ochoa | Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) | May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. {ECO:0000250|UniProtKB:Q80T22}. |
Q5VZ89 | DENND4C | S968 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
Q68D51 | DENND2C | S507 | ochoa | DENN domain-containing protein 2C | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
Q6GTX8 | LAIR1 | S246 | ochoa | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305) | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:10764762, ECO:0000269|PubMed:11069054, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:12072189, ECO:0000269|PubMed:15939744, ECO:0000269|PubMed:15950745, ECO:0000269|PubMed:16380958, ECO:0000269|PubMed:9285412, ECO:0000269|PubMed:9692876}. |
Q6H8Q1 | ABLIM2 | S364 | ochoa | Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
Q6NUJ5 | PWWP2B | S250 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
Q6P4R8 | NFRKB | S495 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
Q6ZMU5 | TRIM72 | S305 | ochoa | Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) | Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:Q1XH17, ECO:0000269|PubMed:36944613}. |
Q6ZRS2 | SRCAP | S349 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
Q6ZSS7 | MFSD6 | S644 | ochoa | Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) | None |
Q6ZV73 | FGD6 | S196 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
Q7LDG7 | RASGRP2 | S391 | ochoa | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
Q7RTP6 | MICAL3 | S1221 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
Q7Z406 | MYH14 | S221 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
Q7Z406 | MYH14 | S337 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
Q7Z6G8 | ANKS1B | S310 | ochoa | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. |
Q86WB0 | ZC3HC1 | S303 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
Q8IVT2 | MISP | S156 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
Q8IW35 | CEP97 | S724 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
Q8IWC1 | MAP7D3 | S234 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
Q8N4C6 | NIN | S1970 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
Q8N8S7 | ENAH | S486 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
Q8NC44 | RETREG2 | S403 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
Q8NDI1 | EHBP1 | T378 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
Q8NEM0 | MCPH1 | S438 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
Q8TAP6 | CEP76 | S83 | ochoa|psp | Centrosomal protein of 76 kDa (Cep76) | Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. {ECO:0000269|PubMed:19460342}. |
Q8TD19 | NEK9 | S332 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
Q8TE77 | SSH3 | S87 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
Q8WUU5 | GATAD1 | S235 | ochoa | GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein) | Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). {ECO:0000269|PubMed:20850016}. |
Q8WUY3 | PRUNE2 | S1789 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
Q8WWM7 | ATXN2L | S559 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
Q8WX93 | PALLD | S192 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
Q92558 | WASF1 | S104 | ochoa | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}. |
Q92576 | PHF3 | S1614 | ochoa | PHD finger protein 3 | None |
Q96GS4 | BORCS6 | S61 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
Q96GU1 | PAGE5 | S31 | ochoa | P antigen family member 5 (PAGE-5) (Cancer/testis antigen 16.1) (CT16.1) (G antigen family E member 1) (Prostate-associated gene 5 protein) | None |
Q96JI7 | SPG11 | S1958 | ochoa | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) | May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}. |
Q96NR8 | RDH12 | S175 | ochoa | Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:15865448, PubMed:19686838). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:12226107, PubMed:15865448). {ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:19686838}. |
Q96QB1 | DLC1 | S566 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
Q96QT4 | TRPM7 | S1388 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
Q99550 | MPHOSPH9 | S874 | ochoa | M-phase phosphoprotein 9 | Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}. |
Q9BR61 | ACBD6 | S106 | ochoa | Acyl-CoA-binding domain-containing protein 6 | Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. Plays a role in protein N-myristoylation (PubMed:37951597). {ECO:0000269|PubMed:18268358, ECO:0000269|PubMed:37951597}. |
Q9BTE3 | MCMBP | S223 | ochoa | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}. |
Q9BUB5 | MKNK1 | S437 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
Q9BYW2 | SETD2 | S614 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
Q9BYW2 | SETD2 | S1216 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
Q9BZL4 | PPP1R12C | S325 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
Q9H2G9 | BLZF1 | S284 | ochoa | Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) | Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}. |
Q9H2G9 | BLZF1 | S353 | ochoa | Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) | Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}. |
Q9H501 | ESF1 | S198 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
Q9H5I1 | SUV39H2 | S382 | ochoa | Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126}. |
Q9HC52 | CBX8 | S191 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
Q9HCM4 | EPB41L5 | S550 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
Q9NP31 | SH2D2A | S217 | ochoa | SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
Q9NPI6 | DCP1A | S142 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
Q9NUQ3 | TXLNG | S97 | ochoa | Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) | May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. {ECO:0000269|PubMed:15911876, ECO:0000269|PubMed:18068885}. |
Q9NVR0 | KLHL11 | S465 | ochoa | Kelch-like protein 11 | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. {ECO:0000250}. |
Q9P0L2 | MARK1 | S394 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
Q9P1Y6 | PHRF1 | S568 | ochoa | PHD and RING finger domain-containing protein 1 | None |
Q9UBB6 | NCDN | S448 | ochoa | Neurochondrin | Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). {ECO:0000269|PubMed:16945926, ECO:0000269|PubMed:33711248, ECO:0000305|PubMed:33711248}. |
Q9UBU9 | NXF1 | S558 | ochoa | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
Q9UER7 | DAXX | S403 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
Q9UER7 | DAXX | S610 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
Q9UGN5 | PARP2 | S34 | ochoa | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:30104678, PubMed:32028527, PubMed:32939087, PubMed:34108479, PubMed:34486521, PubMed:34874266). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30104678, PubMed:30321391). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527, PubMed:34108479, PubMed:34486521, PubMed:34874266). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087, PubMed:34108479). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:34795260). Specifically mediates formation of branched poly-ADP-ribosylation (PubMed:30104678). Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (PubMed:30104678). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034, PubMed:29361132). {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29361132, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:34108479, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266}. |
Q9ULH0 | KIDINS220 | S1718 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
Q9UN79 | SOX13 | S453 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
Q9UP83 | COG5 | S304 | ochoa | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}. |
Q9UPT6 | MAPK8IP3 | S365 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
Q9Y253 | POLH | S601 | psp | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}. |
Q9Y283 | INVS | S614 | ochoa | Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) | Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15852005, ECO:0000269|PubMed:18371931}. |
Q9Y2I7 | PIKFYVE | S1549 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
Q9Y6W5 | WASF2 | S103 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
Q9Y6X4 | FAM169A | S527 | ochoa | Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) | None |
Q86TB9 | PATL1 | S564 | Sugiyama | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
P35372 | OPRM1 | S358 | SIGNOR | Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) | Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}. |
P09497 | CLTB | S206 | Sugiyama | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.019068 | 1.720 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.019068 | 1.720 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.019068 | 1.720 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.019068 | 1.720 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.019068 | 1.720 |
R-HSA-9918440 | Defective visual phototransduction due to RDH12 loss of function | 0.037775 | 1.423 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.046995 | 1.328 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.046995 | 1.328 |
R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.056127 | 1.251 |
R-HSA-74713 | IRS activation | 0.065173 | 1.186 |
R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.009422 | 2.026 |
R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.074132 | 1.130 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.074132 | 1.130 |
R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.083006 | 1.081 |
R-HSA-112412 | SOS-mediated signalling | 0.091795 | 1.037 |
R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 0.091795 | 1.037 |
R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 0.091795 | 1.037 |
R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.091795 | 1.037 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.017788 | 1.750 |
R-HSA-196025 | Formation of annular gap junctions | 0.100501 | 0.998 |
R-HSA-170984 | ARMS-mediated activation | 0.109124 | 0.962 |
R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.109124 | 0.962 |
R-HSA-190873 | Gap junction degradation | 0.109124 | 0.962 |
R-HSA-390522 | Striated Muscle Contraction | 0.007046 | 2.152 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.134502 | 0.871 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.142801 | 0.845 |
R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.151021 | 0.821 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.151021 | 0.821 |
R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.159162 | 0.798 |
R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.175213 | 0.756 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.031811 | 1.497 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.031811 | 1.497 |
R-HSA-110320 | Translesion Synthesis by POLH | 0.206408 | 0.685 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.035284 | 1.452 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.044115 | 1.355 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.229031 | 0.640 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.229031 | 0.640 |
R-HSA-380287 | Centrosome maturation | 0.046821 | 1.330 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.051031 | 1.292 |
R-HSA-429947 | Deadenylation of mRNA | 0.251014 | 0.600 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.067962 | 1.168 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.272374 | 0.565 |
R-HSA-9615710 | Late endosomal microautophagy | 0.286277 | 0.543 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.313296 | 0.504 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.319890 | 0.495 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.326421 | 0.486 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.358155 | 0.446 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.364321 | 0.439 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.364321 | 0.439 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.282388 | 0.549 |
R-HSA-1989781 | PPARA activates gene expression | 0.233146 | 0.632 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.335316 | 0.475 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.335316 | 0.475 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.238224 | 0.623 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.047636 | 1.322 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.015887 | 1.799 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.265322 | 0.576 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.009562 | 2.019 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.008044 | 2.095 |
R-HSA-9646399 | Aggrephagy | 0.075898 | 1.120 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.085615 | 1.067 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.003996 | 2.398 |
R-HSA-9762292 | Regulation of CDH11 function | 0.117664 | 0.929 |
R-HSA-198203 | PI3K/AKT activation | 0.117664 | 0.929 |
R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.126123 | 0.899 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.364321 | 0.439 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.183124 | 0.737 |
R-HSA-9609690 | HCMV Early Events | 0.154455 | 0.811 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.027476 | 1.561 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.073148 | 1.136 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.222113 | 0.653 |
R-HSA-202040 | G-protein activation | 0.221562 | 0.655 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.307183 | 0.513 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.307183 | 0.513 |
R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.002801 | 2.553 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.052426 | 1.280 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.057381 | 1.241 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.324799 | 0.488 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.078680 | 1.104 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.047636 | 1.322 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.236308 | 0.627 |
R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.046995 | 1.328 |
R-HSA-176974 | Unwinding of DNA | 0.006145 | 2.211 |
R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.117664 | 0.929 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.134502 | 0.871 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.151021 | 0.821 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.198721 | 0.702 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.236429 | 0.626 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.085275 | 1.069 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.319890 | 0.495 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.332890 | 0.478 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.339298 | 0.469 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.198721 | 0.702 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.324799 | 0.488 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.286277 | 0.543 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.331718 | 0.479 |
R-HSA-9909396 | Circadian clock | 0.171821 | 0.765 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.024590 | 1.609 |
R-HSA-74749 | Signal attenuation | 0.117664 | 0.929 |
R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.190960 | 0.719 |
R-HSA-9620244 | Long-term potentiation | 0.258203 | 0.588 |
R-HSA-9609646 | HCMV Infection | 0.263011 | 0.580 |
R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.091795 | 1.037 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.175213 | 0.756 |
R-HSA-6811438 | Intra-Golgi traffic | 0.081495 | 1.089 |
R-HSA-9707616 | Heme signaling | 0.146501 | 0.834 |
R-HSA-68877 | Mitotic Prometaphase | 0.149102 | 0.827 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.310714 | 0.508 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.011952 | 1.923 |
R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.142801 | 0.845 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.005694 | 2.245 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.166615 | 0.778 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.017788 | 1.750 |
R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.151021 | 0.821 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.054884 | 1.261 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.221562 | 0.655 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.059981 | 1.222 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.293129 | 0.533 |
R-HSA-69206 | G1/S Transition | 0.153305 | 0.814 |
R-HSA-169893 | Prolonged ERK activation events | 0.175213 | 0.756 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.275286 | 0.560 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.229031 | 0.640 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.261077 | 0.583 |
R-HSA-9842663 | Signaling by LTK | 0.142801 | 0.845 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.044115 | 1.355 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.195800 | 0.708 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.003522 | 2.453 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.286277 | 0.543 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.313296 | 0.504 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.313296 | 0.504 |
R-HSA-5617833 | Cilium Assembly | 0.143823 | 0.842 |
R-HSA-69306 | DNA Replication | 0.228088 | 0.642 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.265322 | 0.576 |
R-HSA-9664407 | Parasite infection | 0.193365 | 0.714 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.193365 | 0.714 |
R-HSA-9664417 | Leishmania phagocytosis | 0.193365 | 0.714 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.134502 | 0.871 |
R-HSA-8866427 | VLDLR internalisation and degradation | 0.142801 | 0.845 |
R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.151021 | 0.821 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.167226 | 0.777 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.229031 | 0.640 |
R-HSA-68949 | Orc1 removal from chromatin | 0.114303 | 0.942 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.272374 | 0.565 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.210565 | 0.677 |
R-HSA-68875 | Mitotic Prophase | 0.139867 | 0.854 |
R-HSA-9663891 | Selective autophagy | 0.239786 | 0.620 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.036430 | 1.439 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.001277 | 2.894 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.054884 | 1.261 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.035284 | 1.452 |
R-HSA-68886 | M Phase | 0.095823 | 1.019 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.293129 | 0.533 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.161705 | 0.791 |
R-HSA-199991 | Membrane Trafficking | 0.112909 | 0.947 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005196 | 2.284 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.142801 | 0.845 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.142801 | 0.845 |
R-HSA-9005895 | Pervasive developmental disorders | 0.142801 | 0.845 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.229031 | 0.640 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.313296 | 0.504 |
R-HSA-187687 | Signalling to ERKs | 0.332890 | 0.478 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.111665 | 0.952 |
R-HSA-69239 | Synthesis of DNA | 0.108238 | 0.966 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.265322 | 0.576 |
R-HSA-5653656 | Vesicle-mediated transport | 0.277434 | 0.557 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.364321 | 0.439 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.058421 | 1.233 |
R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.167226 | 0.777 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.167226 | 0.777 |
R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.190960 | 0.719 |
R-HSA-69481 | G2/M Checkpoints | 0.157872 | 0.802 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.284647 | 0.546 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.084237 | 1.074 |
R-HSA-69242 | S Phase | 0.215541 | 0.666 |
R-HSA-1640170 | Cell Cycle | 0.049955 | 1.301 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.258203 | 0.588 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.180277 | 0.744 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.213049 | 0.672 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.046821 | 1.330 |
R-HSA-1538133 | G0 and Early G1 | 0.306638 | 0.513 |
R-HSA-73894 | DNA Repair | 0.303828 | 0.517 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.043017 | 1.366 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.067749 | 1.169 |
R-HSA-392517 | Rap1 signalling | 0.206408 | 0.685 |
R-HSA-3295583 | TRP channels | 0.265322 | 0.576 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.131821 | 0.880 |
R-HSA-69275 | G2/M Transition | 0.316029 | 0.500 |
R-HSA-69190 | DNA strand elongation | 0.052426 | 1.280 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.321273 | 0.493 |
R-HSA-166208 | mTORC1-mediated signalling | 0.236429 | 0.626 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.339298 | 0.469 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.303649 | 0.518 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.036847 | 1.434 |
R-HSA-397014 | Muscle contraction | 0.186085 | 0.730 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.306638 | 0.513 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.319890 | 0.495 |
R-HSA-5693538 | Homology Directed Repair | 0.039532 | 1.403 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.099979 | 1.000 |
R-HSA-2586552 | Signaling by Leptin | 0.117664 | 0.929 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.229031 | 0.640 |
R-HSA-194138 | Signaling by VEGF | 0.047225 | 1.326 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.243757 | 0.613 |
R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.332890 | 0.478 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.357953 | 0.446 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.229171 | 0.640 |
R-HSA-373760 | L1CAM interactions | 0.356201 | 0.448 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.167226 | 0.777 |
R-HSA-381042 | PERK regulates gene expression | 0.062491 | 1.204 |
R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.243757 | 0.613 |
R-HSA-4839726 | Chromatin organization | 0.119385 | 0.923 |
R-HSA-418885 | DCC mediated attractive signaling | 0.167226 | 0.777 |
R-HSA-6807004 | Negative regulation of MET activity | 0.214021 | 0.670 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.126954 | 0.896 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.038579 | 1.414 |
R-HSA-373753 | Nephrin family interactions | 0.214021 | 0.670 |
R-HSA-2453864 | Retinoid cycle disease events | 0.258203 | 0.588 |
R-HSA-9733709 | Cardiogenesis | 0.313296 | 0.504 |
R-HSA-373755 | Semaphorin interactions | 0.149818 | 0.824 |
R-HSA-2474795 | Diseases associated with visual transduction | 0.258203 | 0.588 |
R-HSA-9675143 | Diseases of the neuronal system | 0.258203 | 0.588 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.279359 | 0.554 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.286277 | 0.543 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.313296 | 0.504 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.326421 | 0.486 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.345785 | 0.461 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.279440 | 0.554 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.308168 | 0.511 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.313296 | 0.504 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.339298 | 0.469 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.352723 | 0.453 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.159428 | 0.797 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.342301 | 0.466 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.317765 | 0.498 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.190632 | 0.720 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.211562 | 0.675 |
R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.175213 | 0.756 |
R-HSA-202433 | Generation of second messenger molecules | 0.364321 | 0.439 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.358155 | 0.446 |
R-HSA-9007101 | Rab regulation of trafficking | 0.359660 | 0.444 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.317765 | 0.498 |
R-HSA-189200 | Cellular hexose transport | 0.236429 | 0.626 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.326421 | 0.486 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.326421 | 0.486 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.359660 | 0.444 |
R-HSA-1474244 | Extracellular matrix organization | 0.250559 | 0.601 |
R-HSA-114452 | Activation of BH3-only proteins | 0.293129 | 0.533 |
R-HSA-422475 | Axon guidance | 0.180733 | 0.743 |
R-HSA-9675108 | Nervous system development | 0.129155 | 0.889 |
R-HSA-201556 | Signaling by ALK | 0.358155 | 0.446 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.090118 | 1.045 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.218591 | 0.660 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.147334 | 0.832 |
R-HSA-354192 | Integrin signaling | 0.313296 | 0.504 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.345644 | 0.461 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.278838 | 0.555 |
R-HSA-1280218 | Adaptive Immune System | 0.228715 | 0.641 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.072971 | 1.137 |
R-HSA-1266695 | Interleukin-7 signaling | 0.258203 | 0.588 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.319890 | 0.495 |
R-HSA-982772 | Growth hormone receptor signaling | 0.243757 | 0.613 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.257525 | 0.589 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.358155 | 0.446 |
R-HSA-195721 | Signaling by WNT | 0.366543 | 0.436 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.370428 | 0.431 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.370428 | 0.431 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.370428 | 0.431 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.376477 | 0.424 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.376477 | 0.424 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.380267 | 0.420 |
R-HSA-2132295 | MHC class II antigen presentation | 0.380267 | 0.420 |
R-HSA-165159 | MTOR signalling | 0.382469 | 0.417 |
R-HSA-5654743 | Signaling by FGFR4 | 0.388403 | 0.411 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.390467 | 0.408 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.390467 | 0.408 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.390467 | 0.408 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.394280 | 0.404 |
R-HSA-190828 | Gap junction trafficking | 0.394280 | 0.404 |
R-HSA-156581 | Methylation | 0.394280 | 0.404 |
R-HSA-69236 | G1 Phase | 0.394280 | 0.404 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.394280 | 0.404 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.394280 | 0.404 |
R-HSA-373752 | Netrin-1 signaling | 0.394280 | 0.404 |
R-HSA-114608 | Platelet degranulation | 0.397226 | 0.401 |
R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 0.400101 | 0.398 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.400101 | 0.398 |
R-HSA-5654741 | Signaling by FGFR3 | 0.400101 | 0.398 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.400593 | 0.397 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.405867 | 0.392 |
R-HSA-8951664 | Neddylation | 0.409828 | 0.387 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.411578 | 0.386 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.411578 | 0.386 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.411578 | 0.386 |
R-HSA-437239 | Recycling pathway of L1 | 0.411578 | 0.386 |
R-HSA-9843745 | Adipogenesis | 0.413972 | 0.383 |
R-HSA-5620924 | Intraflagellar transport | 0.417234 | 0.380 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.417234 | 0.380 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.417234 | 0.380 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.417294 | 0.380 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.420607 | 0.376 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.422620 | 0.374 |
R-HSA-73893 | DNA Damage Bypass | 0.422836 | 0.374 |
R-HSA-9766229 | Degradation of CDH1 | 0.422836 | 0.374 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.422836 | 0.374 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.422836 | 0.374 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.422836 | 0.374 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.422836 | 0.374 |
R-HSA-109704 | PI3K Cascade | 0.428385 | 0.368 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.439323 | 0.357 |
R-HSA-6794361 | Neurexins and neuroligins | 0.439323 | 0.357 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.439323 | 0.357 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.443521 | 0.353 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.444714 | 0.352 |
R-HSA-445355 | Smooth Muscle Contraction | 0.444714 | 0.352 |
R-HSA-1632852 | Macroautophagy | 0.449977 | 0.347 |
R-HSA-72649 | Translation initiation complex formation | 0.450054 | 0.347 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.450054 | 0.347 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.455342 | 0.342 |
R-HSA-3214815 | HDACs deacetylate histones | 0.455342 | 0.342 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.459581 | 0.338 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.460581 | 0.337 |
R-HSA-193648 | NRAGE signals death through JNK | 0.460581 | 0.337 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.460581 | 0.337 |
R-HSA-5654736 | Signaling by FGFR1 | 0.460581 | 0.337 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.460581 | 0.337 |
R-HSA-112399 | IRS-mediated signalling | 0.465768 | 0.332 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.465768 | 0.332 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.465768 | 0.332 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.465768 | 0.332 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.470907 | 0.327 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.470907 | 0.327 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.475372 | 0.323 |
R-HSA-166520 | Signaling by NTRKs | 0.475372 | 0.323 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.475996 | 0.322 |
R-HSA-983189 | Kinesins | 0.481037 | 0.318 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.481037 | 0.318 |
R-HSA-1227986 | Signaling by ERBB2 | 0.481037 | 0.318 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.481037 | 0.318 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.481037 | 0.318 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.481037 | 0.318 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.481037 | 0.318 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.481037 | 0.318 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.481610 | 0.317 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.486029 | 0.313 |
R-HSA-450294 | MAP kinase activation | 0.486029 | 0.313 |
R-HSA-6798695 | Neutrophil degranulation | 0.488651 | 0.311 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.490974 | 0.309 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.490974 | 0.309 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.493951 | 0.306 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.495872 | 0.305 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.495872 | 0.305 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.495872 | 0.305 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.497103 | 0.304 |
R-HSA-9612973 | Autophagy | 0.500052 | 0.301 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.500722 | 0.300 |
R-HSA-2428924 | IGF1R signaling cascade | 0.500722 | 0.300 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.500722 | 0.300 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.504772 | 0.297 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.505526 | 0.296 |
R-HSA-9711097 | Cellular response to starvation | 0.506106 | 0.296 |
R-HSA-9006936 | Signaling by TGFB family members | 0.512112 | 0.291 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.514998 | 0.288 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.514998 | 0.288 |
R-HSA-196807 | Nicotinate metabolism | 0.514998 | 0.288 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.519665 | 0.284 |
R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.519665 | 0.284 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.519665 | 0.284 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.528868 | 0.277 |
R-HSA-448424 | Interleukin-17 signaling | 0.528868 | 0.277 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.533403 | 0.273 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.537894 | 0.269 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.537894 | 0.269 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.539453 | 0.268 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.542343 | 0.266 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.542343 | 0.266 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.542343 | 0.266 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.546750 | 0.262 |
R-HSA-1236394 | Signaling by ERBB4 | 0.546750 | 0.262 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.546750 | 0.262 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.546760 | 0.262 |
R-HSA-8852135 | Protein ubiquitination | 0.551114 | 0.259 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.555370 | 0.255 |
R-HSA-9658195 | Leishmania infection | 0.555370 | 0.255 |
R-HSA-5689603 | UCH proteinases | 0.555436 | 0.255 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.555436 | 0.255 |
R-HSA-162582 | Signal Transduction | 0.560820 | 0.251 |
R-HSA-4086400 | PCP/CE pathway | 0.563957 | 0.249 |
R-HSA-216083 | Integrin cell surface interactions | 0.563957 | 0.249 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.563957 | 0.249 |
R-HSA-9659379 | Sensory processing of sound | 0.568156 | 0.246 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.568156 | 0.246 |
R-HSA-2559583 | Cellular Senescence | 0.572240 | 0.242 |
R-HSA-5654738 | Signaling by FGFR2 | 0.572316 | 0.242 |
R-HSA-6806834 | Signaling by MET | 0.572316 | 0.242 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.576435 | 0.239 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.580515 | 0.236 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.588559 | 0.230 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.592523 | 0.227 |
R-HSA-449147 | Signaling by Interleukins | 0.592546 | 0.227 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.596449 | 0.224 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.596449 | 0.224 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.600337 | 0.222 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.601541 | 0.221 |
R-HSA-438064 | Post NMDA receptor activation events | 0.604188 | 0.219 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.604188 | 0.219 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.614354 | 0.212 |
R-HSA-73884 | Base Excision Repair | 0.615522 | 0.211 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.622898 | 0.206 |
R-HSA-74752 | Signaling by Insulin receptor | 0.626534 | 0.203 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.626534 | 0.203 |
R-HSA-391251 | Protein folding | 0.626534 | 0.203 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.626534 | 0.203 |
R-HSA-1500931 | Cell-Cell communication | 0.629866 | 0.201 |
R-HSA-376176 | Signaling by ROBO receptors | 0.631765 | 0.199 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.633700 | 0.198 |
R-HSA-1474290 | Collagen formation | 0.633700 | 0.198 |
R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.637232 | 0.196 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.644194 | 0.191 |
R-HSA-157579 | Telomere Maintenance | 0.647625 | 0.189 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.651023 | 0.186 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.651023 | 0.186 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.651023 | 0.186 |
R-HSA-190236 | Signaling by FGFR | 0.651023 | 0.186 |
R-HSA-3214847 | HATs acetylate histones | 0.654389 | 0.184 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.654389 | 0.184 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.657723 | 0.182 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.657723 | 0.182 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.657885 | 0.182 |
R-HSA-597592 | Post-translational protein modification | 0.659197 | 0.181 |
R-HSA-9020702 | Interleukin-1 signaling | 0.661024 | 0.180 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.664294 | 0.178 |
R-HSA-1483255 | PI Metabolism | 0.664294 | 0.178 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.664294 | 0.178 |
R-HSA-418990 | Adherens junctions interactions | 0.669263 | 0.174 |
R-HSA-111885 | Opioid Signalling | 0.670740 | 0.173 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.670740 | 0.173 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.677063 | 0.169 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.680179 | 0.167 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.686322 | 0.163 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.686322 | 0.163 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.686322 | 0.163 |
R-HSA-2672351 | Stimuli-sensing channels | 0.686322 | 0.163 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.689350 | 0.162 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.692348 | 0.160 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.692348 | 0.160 |
R-HSA-202403 | TCR signaling | 0.692348 | 0.160 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.693225 | 0.159 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.701172 | 0.154 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.709744 | 0.149 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.715322 | 0.145 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.715322 | 0.145 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.720794 | 0.142 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.723491 | 0.141 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.723491 | 0.141 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.728807 | 0.137 |
R-HSA-73886 | Chromosome Maintenance | 0.728807 | 0.137 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.731427 | 0.136 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.731427 | 0.136 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.734022 | 0.134 |
R-HSA-421270 | Cell-cell junction organization | 0.736874 | 0.133 |
R-HSA-5688426 | Deubiquitination | 0.744221 | 0.128 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.753902 | 0.123 |
R-HSA-212436 | Generic Transcription Pathway | 0.756934 | 0.121 |
R-HSA-168256 | Immune System | 0.760061 | 0.119 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.761423 | 0.118 |
R-HSA-9711123 | Cellular response to chemical stress | 0.766904 | 0.115 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.772305 | 0.112 |
R-HSA-6807070 | PTEN Regulation | 0.778848 | 0.109 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.779356 | 0.108 |
R-HSA-446728 | Cell junction organization | 0.783151 | 0.106 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.787282 | 0.104 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.791378 | 0.102 |
R-HSA-2187338 | Visual phototransduction | 0.797377 | 0.098 |
R-HSA-1266738 | Developmental Biology | 0.798368 | 0.098 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.799876 | 0.097 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.802123 | 0.096 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.806995 | 0.093 |
R-HSA-446652 | Interleukin-1 family signaling | 0.806995 | 0.093 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.808511 | 0.092 |
R-HSA-9609507 | Protein localization | 0.808864 | 0.092 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.809918 | 0.092 |
R-HSA-73887 | Death Receptor Signaling | 0.810714 | 0.091 |
R-HSA-9610379 | HCMV Late Events | 0.816160 | 0.088 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.821450 | 0.085 |
R-HSA-109581 | Apoptosis | 0.824892 | 0.084 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.828268 | 0.082 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.828268 | 0.082 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.833923 | 0.079 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.844204 | 0.074 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.844204 | 0.074 |
R-HSA-5689880 | Ub-specific processing proteases | 0.844204 | 0.074 |
R-HSA-168249 | Innate Immune System | 0.845275 | 0.073 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.847210 | 0.072 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.847210 | 0.072 |
R-HSA-375276 | Peptide ligand-binding receptors | 0.862743 | 0.064 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.865394 | 0.063 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.865458 | 0.063 |
R-HSA-983712 | Ion channel transport | 0.866700 | 0.062 |
R-HSA-5683057 | MAPK family signaling cascades | 0.870509 | 0.060 |
R-HSA-74160 | Gene expression (Transcription) | 0.874455 | 0.058 |
R-HSA-2262752 | Cellular responses to stress | 0.878208 | 0.056 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.883718 | 0.054 |
R-HSA-5357801 | Programmed Cell Death | 0.887074 | 0.052 |
R-HSA-109582 | Hemostasis | 0.891180 | 0.050 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.894534 | 0.048 |
R-HSA-68882 | Mitotic Anaphase | 0.898575 | 0.046 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.899561 | 0.046 |
R-HSA-913531 | Interferon Signaling | 0.902815 | 0.044 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.909798 | 0.041 |
R-HSA-392499 | Metabolism of proteins | 0.910718 | 0.041 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.911545 | 0.040 |
R-HSA-72312 | rRNA processing | 0.913258 | 0.039 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.917398 | 0.037 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.918998 | 0.037 |
R-HSA-8953854 | Metabolism of RNA | 0.919036 | 0.037 |
R-HSA-418594 | G alpha (i) signalling events | 0.919591 | 0.036 |
R-HSA-157118 | Signaling by NOTCH | 0.919786 | 0.036 |
R-HSA-72766 | Translation | 0.932555 | 0.030 |
R-HSA-416476 | G alpha (q) signalling events | 0.936584 | 0.028 |
R-HSA-8953897 | Cellular responses to stimuli | 0.937163 | 0.028 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.945256 | 0.024 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.949619 | 0.022 |
R-HSA-388396 | GPCR downstream signalling | 0.950581 | 0.022 |
R-HSA-112316 | Neuronal System | 0.950839 | 0.022 |
R-HSA-1483257 | Phospholipid metabolism | 0.953210 | 0.021 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.964465 | 0.016 |
R-HSA-8957322 | Metabolism of steroids | 0.964812 | 0.016 |
R-HSA-372790 | Signaling by GPCR | 0.972017 | 0.012 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.972488 | 0.012 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.976269 | 0.010 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.981820 | 0.008 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.982525 | 0.008 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.983035 | 0.007 |
R-HSA-8978868 | Fatty acid metabolism | 0.984632 | 0.007 |
R-HSA-5663205 | Infectious disease | 0.987159 | 0.006 |
R-HSA-9824446 | Viral Infection Pathways | 0.987798 | 0.005 |
R-HSA-382551 | Transport of small molecules | 0.988558 | 0.005 |
R-HSA-211859 | Biological oxidations | 0.995140 | 0.002 |
R-HSA-9679506 | SARS-CoV Infections | 0.996468 | 0.002 |
R-HSA-500792 | GPCR ligand binding | 0.997485 | 0.001 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998119 | 0.001 |
R-HSA-1643685 | Disease | 0.998256 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 0.999176 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999953 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.851 | 0.414 | 1 | 0.810 |
KIS |
0.849 | 0.559 | 1 | 0.913 |
HIPK2 |
0.845 | 0.569 | 1 | 0.907 |
CDK7 |
0.844 | 0.573 | 1 | 0.929 |
CDK18 |
0.844 | 0.590 | 1 | 0.918 |
CDK19 |
0.841 | 0.565 | 1 | 0.926 |
CDK8 |
0.841 | 0.561 | 1 | 0.927 |
DYRK2 |
0.840 | 0.548 | 1 | 0.894 |
CDK17 |
0.840 | 0.599 | 1 | 0.912 |
CDK1 |
0.839 | 0.582 | 1 | 0.925 |
JNK2 |
0.836 | 0.608 | 1 | 0.921 |
SRPK1 |
0.836 | 0.289 | -3 | 0.778 |
NLK |
0.835 | 0.517 | 1 | 0.818 |
P38G |
0.834 | 0.604 | 1 | 0.909 |
CDK3 |
0.834 | 0.537 | 1 | 0.916 |
CDK5 |
0.834 | 0.554 | 1 | 0.920 |
HIPK4 |
0.834 | 0.362 | 1 | 0.802 |
CDK13 |
0.833 | 0.561 | 1 | 0.925 |
HIPK1 |
0.833 | 0.516 | 1 | 0.889 |
CDK16 |
0.832 | 0.576 | 1 | 0.915 |
DYRK4 |
0.831 | 0.557 | 1 | 0.922 |
CDK12 |
0.830 | 0.563 | 1 | 0.923 |
CDK10 |
0.830 | 0.552 | 1 | 0.917 |
JNK3 |
0.830 | 0.591 | 1 | 0.924 |
P38B |
0.829 | 0.582 | 1 | 0.887 |
ERK1 |
0.829 | 0.570 | 1 | 0.891 |
CDK14 |
0.829 | 0.568 | 1 | 0.912 |
CLK2 |
0.827 | 0.350 | -3 | 0.770 |
P38D |
0.826 | 0.586 | 1 | 0.923 |
COT |
0.825 | 0.043 | 2 | 0.841 |
SRPK2 |
0.825 | 0.232 | -3 | 0.702 |
DYRK1B |
0.824 | 0.524 | 1 | 0.907 |
CDK9 |
0.824 | 0.539 | 1 | 0.919 |
P38A |
0.823 | 0.548 | 1 | 0.878 |
DYRK1A |
0.823 | 0.450 | 1 | 0.895 |
ICK |
0.822 | 0.294 | -3 | 0.853 |
CLK4 |
0.821 | 0.303 | -3 | 0.788 |
CLK1 |
0.821 | 0.319 | -3 | 0.769 |
ERK5 |
0.821 | 0.256 | 1 | 0.706 |
MOS |
0.821 | 0.168 | 1 | 0.615 |
ERK2 |
0.820 | 0.551 | 1 | 0.895 |
HIPK3 |
0.819 | 0.486 | 1 | 0.856 |
CDKL1 |
0.819 | 0.149 | -3 | 0.816 |
NDR2 |
0.818 | 0.021 | -3 | 0.862 |
PIM3 |
0.817 | 0.023 | -3 | 0.851 |
CDKL5 |
0.816 | 0.150 | -3 | 0.814 |
MTOR |
0.815 | 0.076 | 1 | 0.637 |
DYRK3 |
0.815 | 0.411 | 1 | 0.864 |
CDK2 |
0.814 | 0.422 | 1 | 0.884 |
PRKD1 |
0.812 | 0.035 | -3 | 0.849 |
GRK1 |
0.812 | 0.135 | -2 | 0.763 |
PRPK |
0.812 | -0.071 | -1 | 0.649 |
CDC7 |
0.812 | -0.080 | 1 | 0.577 |
PRKD2 |
0.812 | 0.055 | -3 | 0.804 |
CDK4 |
0.812 | 0.551 | 1 | 0.927 |
SRPK3 |
0.811 | 0.203 | -3 | 0.741 |
MAK |
0.811 | 0.405 | -2 | 0.779 |
CAMK1B |
0.810 | 0.017 | -3 | 0.856 |
JNK1 |
0.809 | 0.528 | 1 | 0.922 |
RSK2 |
0.809 | 0.038 | -3 | 0.796 |
PRP4 |
0.808 | 0.357 | -3 | 0.790 |
CDK6 |
0.808 | 0.527 | 1 | 0.910 |
PIM1 |
0.808 | 0.053 | -3 | 0.803 |
PKN3 |
0.808 | 0.007 | -3 | 0.841 |
NDR1 |
0.807 | -0.007 | -3 | 0.846 |
AURC |
0.807 | 0.056 | -2 | 0.702 |
ATR |
0.806 | -0.029 | 1 | 0.597 |
SKMLCK |
0.806 | 0.001 | -2 | 0.855 |
CAMLCK |
0.805 | 0.031 | -2 | 0.841 |
P90RSK |
0.803 | 0.015 | -3 | 0.800 |
WNK1 |
0.803 | -0.060 | -2 | 0.857 |
BMPR2 |
0.802 | -0.162 | -2 | 0.836 |
PKACG |
0.802 | 0.019 | -2 | 0.771 |
MST4 |
0.802 | -0.020 | 2 | 0.800 |
RAF1 |
0.802 | -0.177 | 1 | 0.536 |
IKKB |
0.801 | -0.135 | -2 | 0.689 |
P70S6KB |
0.801 | 0.025 | -3 | 0.806 |
NIK |
0.801 | -0.054 | -3 | 0.864 |
PKACB |
0.800 | 0.068 | -2 | 0.720 |
PKN2 |
0.800 | -0.020 | -3 | 0.842 |
CAMK2G |
0.800 | -0.066 | 2 | 0.774 |
PKCD |
0.800 | -0.015 | 2 | 0.733 |
RSK3 |
0.800 | 0.001 | -3 | 0.786 |
DAPK2 |
0.800 | -0.004 | -3 | 0.864 |
NUAK2 |
0.799 | -0.014 | -3 | 0.857 |
PRKX |
0.799 | 0.089 | -3 | 0.732 |
TBK1 |
0.799 | -0.175 | 1 | 0.456 |
LATS2 |
0.799 | -0.041 | -5 | 0.730 |
MAPKAPK2 |
0.799 | 0.016 | -3 | 0.759 |
PDHK4 |
0.799 | -0.248 | 1 | 0.595 |
RIPK3 |
0.798 | -0.089 | 3 | 0.757 |
MAPKAPK3 |
0.798 | -0.020 | -3 | 0.798 |
CHAK2 |
0.798 | -0.058 | -1 | 0.616 |
NEK6 |
0.798 | -0.097 | -2 | 0.804 |
DSTYK |
0.797 | -0.143 | 2 | 0.845 |
MOK |
0.797 | 0.358 | 1 | 0.799 |
ULK2 |
0.797 | -0.212 | 2 | 0.756 |
TGFBR2 |
0.797 | -0.093 | -2 | 0.746 |
RSK4 |
0.796 | 0.045 | -3 | 0.780 |
AMPKA1 |
0.796 | -0.056 | -3 | 0.864 |
LATS1 |
0.796 | 0.049 | -3 | 0.867 |
PRKD3 |
0.796 | 0.030 | -3 | 0.769 |
GCN2 |
0.796 | -0.213 | 2 | 0.758 |
PKG2 |
0.795 | 0.046 | -2 | 0.725 |
IKKE |
0.795 | -0.171 | 1 | 0.449 |
IKKA |
0.793 | -0.075 | -2 | 0.674 |
PAK1 |
0.793 | -0.018 | -2 | 0.804 |
NEK7 |
0.793 | -0.186 | -3 | 0.826 |
AURB |
0.793 | 0.024 | -2 | 0.694 |
MNK2 |
0.793 | -0.016 | -2 | 0.795 |
AMPKA2 |
0.792 | -0.041 | -3 | 0.838 |
MLK1 |
0.792 | -0.135 | 2 | 0.765 |
GRK5 |
0.792 | -0.167 | -3 | 0.825 |
AKT2 |
0.791 | 0.058 | -3 | 0.724 |
TSSK1 |
0.791 | -0.049 | -3 | 0.880 |
PAK6 |
0.790 | 0.021 | -2 | 0.711 |
PAK3 |
0.790 | -0.049 | -2 | 0.792 |
TSSK2 |
0.790 | -0.067 | -5 | 0.825 |
MSK2 |
0.790 | -0.012 | -3 | 0.767 |
PDHK1 |
0.790 | -0.263 | 1 | 0.567 |
DLK |
0.790 | -0.127 | 1 | 0.553 |
BMPR1B |
0.789 | -0.013 | 1 | 0.522 |
PKCB |
0.789 | -0.028 | 2 | 0.680 |
HUNK |
0.789 | -0.165 | 2 | 0.791 |
WNK3 |
0.789 | -0.214 | 1 | 0.528 |
GRK7 |
0.789 | 0.015 | 1 | 0.533 |
CAMK4 |
0.789 | -0.074 | -3 | 0.825 |
MNK1 |
0.788 | -0.009 | -2 | 0.803 |
CAMK2D |
0.788 | -0.101 | -3 | 0.842 |
ULK1 |
0.788 | -0.194 | -3 | 0.791 |
MARK4 |
0.788 | -0.119 | 4 | 0.788 |
MSK1 |
0.788 | 0.017 | -3 | 0.770 |
GRK6 |
0.787 | -0.105 | 1 | 0.553 |
PKCG |
0.787 | -0.036 | 2 | 0.675 |
MYLK4 |
0.787 | 0.009 | -2 | 0.786 |
MLK2 |
0.787 | -0.131 | 2 | 0.778 |
RIPK1 |
0.787 | -0.173 | 1 | 0.517 |
CAMK2B |
0.786 | -0.030 | 2 | 0.748 |
TGFBR1 |
0.786 | -0.032 | -2 | 0.740 |
GSK3A |
0.786 | 0.171 | 4 | 0.513 |
MASTL |
0.786 | -0.200 | -2 | 0.762 |
PIM2 |
0.786 | 0.036 | -3 | 0.771 |
CAMK2A |
0.786 | -0.012 | 2 | 0.751 |
PKCA |
0.786 | -0.033 | 2 | 0.672 |
IRE1 |
0.785 | -0.119 | 1 | 0.516 |
SGK3 |
0.785 | 0.010 | -3 | 0.794 |
ATM |
0.785 | -0.070 | 1 | 0.549 |
MELK |
0.785 | -0.066 | -3 | 0.818 |
NUAK1 |
0.785 | -0.049 | -3 | 0.802 |
VRK2 |
0.785 | -0.025 | 1 | 0.635 |
FAM20C |
0.784 | 0.006 | 2 | 0.618 |
ALK4 |
0.784 | -0.068 | -2 | 0.768 |
MLK3 |
0.784 | -0.068 | 2 | 0.681 |
PKR |
0.784 | -0.089 | 1 | 0.560 |
AURA |
0.784 | 0.011 | -2 | 0.665 |
NIM1 |
0.783 | -0.124 | 3 | 0.809 |
BCKDK |
0.783 | -0.199 | -1 | 0.563 |
GRK4 |
0.782 | -0.155 | -2 | 0.788 |
ACVR2B |
0.782 | -0.015 | -2 | 0.744 |
NEK9 |
0.782 | -0.238 | 2 | 0.801 |
PHKG1 |
0.782 | -0.069 | -3 | 0.833 |
PKCZ |
0.782 | -0.068 | 2 | 0.733 |
PKACA |
0.781 | 0.044 | -2 | 0.678 |
ANKRD3 |
0.781 | -0.171 | 1 | 0.552 |
PAK2 |
0.781 | -0.058 | -2 | 0.780 |
PKCH |
0.781 | -0.062 | 2 | 0.670 |
MPSK1 |
0.781 | 0.032 | 1 | 0.554 |
ERK7 |
0.781 | 0.152 | 2 | 0.483 |
IRE2 |
0.780 | -0.110 | 2 | 0.714 |
ACVR2A |
0.780 | -0.048 | -2 | 0.732 |
DNAPK |
0.779 | -0.051 | 1 | 0.505 |
PLK1 |
0.779 | -0.111 | -2 | 0.765 |
QSK |
0.778 | -0.077 | 4 | 0.765 |
AKT1 |
0.777 | 0.031 | -3 | 0.744 |
QIK |
0.777 | -0.129 | -3 | 0.840 |
SIK |
0.777 | -0.068 | -3 | 0.777 |
PASK |
0.777 | 0.023 | -3 | 0.873 |
GSK3B |
0.776 | 0.063 | 4 | 0.506 |
CHAK1 |
0.776 | -0.158 | 2 | 0.752 |
CHK1 |
0.776 | -0.071 | -3 | 0.830 |
ALK2 |
0.776 | -0.064 | -2 | 0.750 |
MEK1 |
0.776 | -0.173 | 2 | 0.795 |
SMG1 |
0.776 | -0.104 | 1 | 0.564 |
TTBK2 |
0.776 | -0.214 | 2 | 0.669 |
CAMK1G |
0.775 | -0.027 | -3 | 0.770 |
MLK4 |
0.774 | -0.120 | 2 | 0.669 |
DCAMKL1 |
0.774 | -0.050 | -3 | 0.809 |
CK1E |
0.774 | 0.006 | -3 | 0.545 |
GRK2 |
0.774 | -0.064 | -2 | 0.679 |
YSK4 |
0.773 | -0.183 | 1 | 0.486 |
SMMLCK |
0.773 | -0.006 | -3 | 0.821 |
NEK2 |
0.773 | -0.190 | 2 | 0.769 |
MST3 |
0.772 | -0.042 | 2 | 0.786 |
PINK1 |
0.772 | -0.001 | 1 | 0.696 |
BUB1 |
0.772 | 0.085 | -5 | 0.797 |
BRSK1 |
0.772 | -0.085 | -3 | 0.805 |
TLK2 |
0.772 | -0.156 | 1 | 0.533 |
MAPKAPK5 |
0.771 | -0.080 | -3 | 0.729 |
DRAK1 |
0.771 | -0.111 | 1 | 0.496 |
PKCT |
0.771 | -0.059 | 2 | 0.681 |
WNK4 |
0.770 | -0.138 | -2 | 0.833 |
P70S6K |
0.770 | -0.021 | -3 | 0.728 |
SSTK |
0.770 | -0.053 | 4 | 0.756 |
PAK5 |
0.770 | -0.018 | -2 | 0.651 |
BMPR1A |
0.769 | -0.045 | 1 | 0.512 |
AKT3 |
0.769 | 0.046 | -3 | 0.674 |
IRAK4 |
0.769 | -0.146 | 1 | 0.502 |
DAPK3 |
0.769 | 0.014 | -3 | 0.814 |
BRSK2 |
0.769 | -0.128 | -3 | 0.822 |
PAK4 |
0.768 | -0.004 | -2 | 0.661 |
PLK4 |
0.768 | -0.143 | 2 | 0.601 |
GAK |
0.768 | 0.002 | 1 | 0.569 |
CK1D |
0.768 | 0.019 | -3 | 0.497 |
TAO3 |
0.767 | -0.073 | 1 | 0.537 |
SGK1 |
0.767 | 0.054 | -3 | 0.653 |
PKCE |
0.767 | -0.002 | 2 | 0.664 |
MARK3 |
0.767 | -0.104 | 4 | 0.708 |
MEK5 |
0.767 | -0.195 | 2 | 0.785 |
BRAF |
0.767 | -0.167 | -4 | 0.805 |
SNRK |
0.767 | -0.155 | 2 | 0.651 |
CAMK1D |
0.766 | -0.017 | -3 | 0.716 |
DCAMKL2 |
0.765 | -0.067 | -3 | 0.821 |
PERK |
0.765 | -0.196 | -2 | 0.770 |
CK1A2 |
0.764 | 0.012 | -3 | 0.498 |
MARK2 |
0.764 | -0.121 | 4 | 0.667 |
MEKK3 |
0.764 | -0.157 | 1 | 0.519 |
ZAK |
0.764 | -0.186 | 1 | 0.502 |
PHKG2 |
0.764 | -0.079 | -3 | 0.804 |
MRCKA |
0.764 | 0.020 | -3 | 0.771 |
MEKK1 |
0.764 | -0.200 | 1 | 0.533 |
NEK5 |
0.764 | -0.198 | 1 | 0.528 |
PKCI |
0.763 | -0.058 | 2 | 0.690 |
HRI |
0.763 | -0.214 | -2 | 0.793 |
MRCKB |
0.763 | 0.024 | -3 | 0.761 |
PLK3 |
0.763 | -0.166 | 2 | 0.737 |
ROCK2 |
0.763 | 0.021 | -3 | 0.812 |
LKB1 |
0.763 | -0.093 | -3 | 0.830 |
DAPK1 |
0.763 | 0.014 | -3 | 0.801 |
SBK |
0.762 | 0.092 | -3 | 0.611 |
MEKK2 |
0.762 | -0.168 | 2 | 0.763 |
MARK1 |
0.759 | -0.135 | 4 | 0.737 |
GRK3 |
0.759 | -0.063 | -2 | 0.638 |
CK2A2 |
0.759 | -0.014 | 1 | 0.488 |
DMPK1 |
0.759 | 0.062 | -3 | 0.779 |
TAO2 |
0.759 | -0.106 | 2 | 0.804 |
TLK1 |
0.758 | -0.192 | -2 | 0.784 |
NEK11 |
0.758 | -0.157 | 1 | 0.522 |
PKN1 |
0.757 | -0.038 | -3 | 0.748 |
PDK1 |
0.757 | -0.106 | 1 | 0.532 |
GCK |
0.756 | -0.088 | 1 | 0.518 |
CHK2 |
0.756 | -0.008 | -3 | 0.672 |
HASPIN |
0.755 | -0.005 | -1 | 0.506 |
CAMK1A |
0.755 | -0.008 | -3 | 0.687 |
NEK8 |
0.755 | -0.201 | 2 | 0.777 |
CAMKK1 |
0.754 | -0.218 | -2 | 0.697 |
TNIK |
0.754 | -0.080 | 3 | 0.908 |
MAP3K15 |
0.753 | -0.133 | 1 | 0.495 |
MEKK6 |
0.753 | -0.145 | 1 | 0.508 |
PKG1 |
0.753 | -0.000 | -2 | 0.654 |
IRAK1 |
0.752 | -0.241 | -1 | 0.556 |
HGK |
0.752 | -0.120 | 3 | 0.908 |
CAMKK2 |
0.752 | -0.185 | -2 | 0.691 |
CRIK |
0.751 | 0.032 | -3 | 0.749 |
LRRK2 |
0.751 | -0.115 | 2 | 0.805 |
HPK1 |
0.751 | -0.092 | 1 | 0.501 |
CK2A1 |
0.751 | -0.011 | 1 | 0.472 |
LOK |
0.751 | -0.111 | -2 | 0.732 |
CK1G1 |
0.751 | -0.095 | -3 | 0.524 |
EEF2K |
0.751 | -0.104 | 3 | 0.871 |
TAK1 |
0.751 | -0.143 | 1 | 0.531 |
VRK1 |
0.751 | -0.154 | 2 | 0.817 |
MINK |
0.750 | -0.141 | 1 | 0.491 |
PDHK3_TYR |
0.748 | 0.203 | 4 | 0.903 |
NEK4 |
0.748 | -0.223 | 1 | 0.495 |
PBK |
0.748 | -0.067 | 1 | 0.503 |
KHS2 |
0.748 | -0.052 | 1 | 0.511 |
KHS1 |
0.748 | -0.084 | 1 | 0.493 |
MST2 |
0.748 | -0.158 | 1 | 0.513 |
ROCK1 |
0.748 | 0.006 | -3 | 0.771 |
TTBK1 |
0.747 | -0.209 | 2 | 0.593 |
SLK |
0.746 | -0.107 | -2 | 0.670 |
NEK1 |
0.745 | -0.208 | 1 | 0.498 |
STK33 |
0.741 | -0.166 | 2 | 0.571 |
YSK1 |
0.741 | -0.152 | 2 | 0.766 |
MST1 |
0.740 | -0.179 | 1 | 0.495 |
RIPK2 |
0.740 | -0.220 | 1 | 0.467 |
BMPR2_TYR |
0.740 | 0.240 | -1 | 0.747 |
PDHK4_TYR |
0.740 | 0.143 | 2 | 0.843 |
PLK2 |
0.739 | -0.101 | -3 | 0.714 |
TESK1_TYR |
0.739 | 0.068 | 3 | 0.920 |
BIKE |
0.738 | -0.043 | 1 | 0.488 |
OSR1 |
0.738 | -0.082 | 2 | 0.747 |
LIMK2_TYR |
0.737 | 0.080 | -3 | 0.876 |
PKMYT1_TYR |
0.736 | 0.078 | 3 | 0.881 |
TTK |
0.735 | -0.097 | -2 | 0.783 |
MAP2K6_TYR |
0.735 | 0.073 | -1 | 0.676 |
ALPHAK3 |
0.735 | -0.059 | -1 | 0.617 |
MAP2K4_TYR |
0.733 | -0.009 | -1 | 0.657 |
MEK2 |
0.733 | -0.284 | 2 | 0.775 |
PDHK1_TYR |
0.732 | 0.055 | -1 | 0.705 |
EPHA6 |
0.731 | 0.097 | -1 | 0.730 |
NEK3 |
0.731 | -0.211 | 1 | 0.489 |
MAP2K7_TYR |
0.730 | -0.084 | 2 | 0.827 |
MYO3B |
0.729 | -0.120 | 2 | 0.775 |
ASK1 |
0.729 | -0.164 | 1 | 0.492 |
PINK1_TYR |
0.729 | -0.051 | 1 | 0.587 |
TXK |
0.729 | 0.055 | 1 | 0.542 |
AAK1 |
0.728 | -0.014 | 1 | 0.430 |
MYO3A |
0.725 | -0.129 | 1 | 0.511 |
EPHB4 |
0.725 | -0.012 | -1 | 0.662 |
YANK3 |
0.725 | -0.071 | 2 | 0.363 |
TAO1 |
0.725 | -0.140 | 1 | 0.471 |
RET |
0.725 | -0.100 | 1 | 0.532 |
LCK |
0.723 | 0.093 | -1 | 0.738 |
CK1A |
0.723 | -0.039 | -3 | 0.406 |
LIMK1_TYR |
0.722 | -0.083 | 2 | 0.822 |
MST1R |
0.721 | -0.073 | 3 | 0.854 |
JAK3 |
0.720 | 0.003 | 1 | 0.522 |
JAK2 |
0.719 | -0.090 | 1 | 0.529 |
ABL2 |
0.719 | -0.061 | -1 | 0.620 |
TYRO3 |
0.718 | -0.151 | 3 | 0.849 |
TYK2 |
0.718 | -0.170 | 1 | 0.518 |
BLK |
0.718 | 0.066 | -1 | 0.740 |
YES1 |
0.718 | -0.064 | -1 | 0.666 |
HCK |
0.718 | 0.016 | -1 | 0.714 |
ITK |
0.717 | -0.025 | -1 | 0.661 |
CSF1R |
0.717 | -0.089 | 3 | 0.822 |
ROS1 |
0.717 | -0.135 | 3 | 0.810 |
BMX |
0.716 | -0.019 | -1 | 0.621 |
FYN |
0.714 | 0.103 | -1 | 0.766 |
EPHA4 |
0.714 | -0.013 | 2 | 0.736 |
FGFR2 |
0.714 | -0.044 | 3 | 0.825 |
ABL1 |
0.714 | -0.090 | -1 | 0.609 |
INSRR |
0.714 | -0.061 | 3 | 0.786 |
TNK2 |
0.713 | -0.112 | 3 | 0.793 |
EPHB1 |
0.713 | -0.065 | 1 | 0.528 |
FER |
0.713 | -0.143 | 1 | 0.562 |
DDR1 |
0.713 | -0.155 | 4 | 0.793 |
FGR |
0.712 | -0.128 | 1 | 0.532 |
EPHB3 |
0.712 | -0.062 | -1 | 0.655 |
STLK3 |
0.712 | -0.204 | 1 | 0.481 |
KDR |
0.712 | -0.039 | 3 | 0.784 |
SRMS |
0.711 | -0.107 | 1 | 0.537 |
EPHB2 |
0.711 | -0.048 | -1 | 0.657 |
MET |
0.711 | -0.012 | 3 | 0.833 |
NEK10_TYR |
0.711 | -0.123 | 1 | 0.450 |
TEK |
0.710 | -0.032 | 3 | 0.775 |
KIT |
0.709 | -0.090 | 3 | 0.827 |
TNK1 |
0.709 | -0.119 | 3 | 0.821 |
PTK2 |
0.709 | 0.156 | -1 | 0.787 |
FGFR1 |
0.709 | -0.081 | 3 | 0.803 |
JAK1 |
0.708 | -0.105 | 1 | 0.474 |
TEC |
0.707 | -0.107 | -1 | 0.585 |
TNNI3K_TYR |
0.707 | -0.106 | 1 | 0.555 |
FLT3 |
0.707 | -0.145 | 3 | 0.841 |
WEE1_TYR |
0.707 | -0.084 | -1 | 0.566 |
MERTK |
0.706 | -0.138 | 3 | 0.807 |
FLT1 |
0.705 | -0.021 | -1 | 0.693 |
EPHA7 |
0.705 | -0.036 | 2 | 0.738 |
AXL |
0.705 | -0.177 | 3 | 0.810 |
SYK |
0.705 | 0.116 | -1 | 0.745 |
PDGFRB |
0.704 | -0.202 | 3 | 0.848 |
FRK |
0.704 | -0.038 | -1 | 0.706 |
DDR2 |
0.704 | -0.034 | 3 | 0.768 |
FGFR3 |
0.702 | -0.052 | 3 | 0.799 |
BTK |
0.702 | -0.181 | -1 | 0.600 |
EPHA1 |
0.701 | -0.089 | 3 | 0.811 |
EPHA8 |
0.701 | 0.012 | -1 | 0.712 |
EPHA3 |
0.700 | -0.078 | 2 | 0.712 |
LYN |
0.700 | -0.036 | 3 | 0.739 |
ERBB2 |
0.700 | -0.094 | 1 | 0.499 |
ALK |
0.698 | -0.162 | 3 | 0.764 |
EPHA5 |
0.697 | -0.061 | 2 | 0.723 |
PDGFRA |
0.697 | -0.229 | 3 | 0.845 |
SRC |
0.697 | -0.032 | -1 | 0.709 |
PTK2B |
0.697 | -0.099 | -1 | 0.593 |
EGFR |
0.696 | -0.064 | 1 | 0.442 |
LTK |
0.695 | -0.179 | 3 | 0.775 |
MATK |
0.695 | -0.117 | -1 | 0.558 |
PTK6 |
0.695 | -0.231 | -1 | 0.550 |
CK1G3 |
0.694 | -0.074 | -3 | 0.362 |
FLT4 |
0.694 | -0.138 | 3 | 0.764 |
INSR |
0.693 | -0.147 | 3 | 0.763 |
ERBB4 |
0.692 | 0.018 | 1 | 0.460 |
NTRK1 |
0.691 | -0.223 | -1 | 0.606 |
EPHA2 |
0.691 | -0.002 | -1 | 0.678 |
ZAP70 |
0.691 | 0.051 | -1 | 0.669 |
NTRK3 |
0.690 | -0.163 | -1 | 0.574 |
NTRK2 |
0.689 | -0.228 | 3 | 0.789 |
YANK2 |
0.688 | -0.098 | 2 | 0.375 |
CK1G2 |
0.688 | -0.008 | -3 | 0.448 |
CSK |
0.688 | -0.145 | 2 | 0.744 |
FGFR4 |
0.687 | -0.109 | -1 | 0.595 |
MUSK |
0.686 | -0.114 | 1 | 0.413 |
IGF1R |
0.680 | -0.107 | 3 | 0.703 |
FES |
0.672 | -0.122 | -1 | 0.583 |