Motif 742 (n=143)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0C4DFX4 None S330 ochoa Snf2 related CREBBP activator protein None
A0A0J9YVX5 None S175 ochoa Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) None
A0A1W2PPC1 PRR33 S311 ochoa Proline rich 33 None
A2RUB6 CCDC66 S797 ochoa Coiled-coil domain-containing protein 66 Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Required for the assembly of signaling-competent cilia with proper structure and length (PubMed:36606424). Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex (PubMed:36606424). Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation (PubMed:36606424). Plays two important roles during cell division (PubMed:35849559). First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment (PubMed:35849559). Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs (PubMed:35849559). Plays a role in retina morphogenesis and/or homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6NS45, ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559}.
A8MZF0 PRR33 S163 ochoa Proline-rich protein 33 None
O00159 MYO1C S864 ochoa Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}.
O00472 ELL2 S503 ochoa RNA polymerase II elongation factor ELL2 Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}.
O14924 RGS12 S850 ochoa Regulator of G-protein signaling 12 (RGS12) Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. {ECO:0000250|UniProtKB:O08774}.; FUNCTION: [Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. {ECO:0000269|PubMed:12024043}.
O15085 ARHGEF11 S1458 ochoa Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
O43187 IRAK2 S144 ochoa Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}.
O60291 MGRN1 S515 ochoa E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
O60336 MAPKBP1 S761 ochoa Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.
O60568 PLOD3 S702 ochoa Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)] Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812, PubMed:9582318, PubMed:9724729). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity). {ECO:0000250|UniProtKB:Q9R0E1, ECO:0000269|PubMed:10934207, ECO:0000269|PubMed:11896059, ECO:0000269|PubMed:11956192, ECO:0000269|PubMed:12475640, ECO:0000269|PubMed:18298658, ECO:0000269|PubMed:18834968, ECO:0000269|PubMed:25419660, ECO:0000269|PubMed:30089812, ECO:0000269|PubMed:9582318, ECO:0000269|PubMed:9724729, ECO:0000305}.
O60716 CTNND1 S47 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O60941 DTNB S535 ochoa Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}.
O75150 RNF40 S601 ochoa E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
O75376 NCOR1 S990 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75676 RPS6KA4 S682 ochoa Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.
O75970 MPDZ S354 ochoa Multiple PDZ domain protein (Multi-PDZ domain protein 1) Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}.
O94811 TPPP S160 ochoa|psp Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}.
O95235 KIF20A S109 ochoa Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95382 MAP3K6 S1149 ochoa Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}.
O95613 PCNT S2327 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
O96020 CCNE2 S383 ochoa G1/S-specific cyclin-E2 Essential for the control of the cell cycle at the late G1 and early S phase. {ECO:0000269|PubMed:9840927, ECO:0000269|PubMed:9840943, ECO:0000269|PubMed:9858585}.
P05107 ITGB2 S350 ochoa Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055}.
P07451 CA3 S219 ochoa Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}.
P11532 DMD S3613 ochoa Dystrophin Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}.
P13521 SCG2 S556 ochoa Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. {ECO:0000269|PubMed:19357184}.
P18847 ATF3 S59 ochoa Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. {ECO:0000269|PubMed:7515060}.; FUNCTION: [Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. {ECO:0000269|PubMed:7515060}.; FUNCTION: [Isoform 3]: Stress-induced isoform, counteracts the transcriptional repression of isoform 1. {ECO:0000269|PubMed:12034827}.
P23508 MCC S294 ochoa Colorectal mutant cancer protein (Protein MCC) Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}.
P24534 EEF1B2 S175 ochoa Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}.
P28290 ITPRID2 S650 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P35568 IRS1 S604 ochoa Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P35609 ACTN2 S596 ochoa Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
P39880 CUX1 S1321 ochoa Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
P40261 NNMT S108 ochoa Nicotinamide N-methyltransferase (EC 2.1.1.1) Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23455543, PubMed:8182091). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:23455543, PubMed:26571212, PubMed:31043742). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909). {ECO:0000250|UniProtKB:O55239, ECO:0000269|PubMed:21823666, ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:26571212, ECO:0000269|PubMed:30044909, ECO:0000269|PubMed:31043742, ECO:0000269|PubMed:8182091}.
P40818 USP8 S434 ochoa Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}.
P40855 PEX19 S35 ochoa Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}.
P46013 MKI67 S2828 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46013 MKI67 S3128 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46087 NOP2 S675 ochoa 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
P46939 UTRN S1408 ochoa Utrophin (Dystrophin-related protein 1) (DRP-1) May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.
P49736 MCM2 S381 ochoa DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}.
P51826 AFF3 S755 ochoa AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
P57076 CFAP298 S267 ochoa Cilia- and flagella-associated protein 298 (Protein kurly homolog) Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). {ECO:0000250|UniProtKB:Q6DRC3, ECO:0000269|PubMed:24094744}.
P61964 WDR5 S20 ochoa WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
Q01484 ANK2 S2172 ochoa Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
Q02952 AKAP12 S483 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03164 KMT2A S1115 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04637 EIF4G1 S1028 ochoa Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}.
Q08AE8 SPIRE1 S508 ochoa Protein spire homolog 1 (Spir-1) Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}.
Q12830 BPTF S1382 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q12888 TP53BP1 S484 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13015 MLLT11 S44 ochoa Protein AF1q Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}.
Q13133 NR1H3 S198 ochoa|psp Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (PubMed:37478846). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). {ECO:0000250|UniProtKB:Q9Z0Y9, ECO:0000269|PubMed:19481530, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:37478846}.
Q14978 NOLC1 S291 ochoa Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.
Q15059 BRD3 S682 ochoa Bromodomain-containing protein 3 (RING3-like protein) Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}.
Q15326 ZMYND11 S447 ochoa Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}.
Q17R98 ZNF827 S689 ochoa Zinc finger protein 827 As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}.
Q27J81 INF2 S351 ochoa Inverted formin-2 (HBEBP2-binding protein C) Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}.
Q2LD37 BLTP1 S1682 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q2M3G4 SHROOM1 S408 ochoa Protein Shroom1 (Apical protein 2) May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}.
Q3L8U1 CHD9 S2059 ochoa Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Q4G163 FBXO43 S121 ochoa F-box only protein 43 (Endogenous meiotic inhibitor 2) Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}.
Q5D1E8 ZC3H12A S99 ochoa Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:22561375, PubMed:26134560, PubMed:26320658). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q5D1E7, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:19185603, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:22561375, ECO:0000269|PubMed:24048733, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:26134560, ECO:0000269|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269|PubMed:24191027}.
Q5T0N5 FNBP1L S489 ochoa Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.
Q5T4S7 UBR4 S1763 ochoa E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}.
Q5TF39 MFSD4B S496 ochoa Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. {ECO:0000250|UniProtKB:Q80T22}.
Q5VZ89 DENND4C S968 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q68D51 DENND2C S507 ochoa DENN domain-containing protein 2C Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.
Q6GTX8 LAIR1 S246 ochoa Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305) Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:10764762, ECO:0000269|PubMed:11069054, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:12072189, ECO:0000269|PubMed:15939744, ECO:0000269|PubMed:15950745, ECO:0000269|PubMed:16380958, ECO:0000269|PubMed:9285412, ECO:0000269|PubMed:9692876}.
Q6H8Q1 ABLIM2 S364 ochoa Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.
Q6NUJ5 PWWP2B S250 ochoa PWWP domain-containing protein 2B Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}.
Q6P4R8 NFRKB S495 ochoa Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}.
Q6ZMU5 TRIM72 S305 ochoa Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53) Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:Q1XH17, ECO:0000269|PubMed:36944613}.
Q6ZRS2 SRCAP S349 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q6ZSS7 MFSD6 S644 ochoa Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) None
Q6ZV73 FGD6 S196 ochoa FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q7LDG7 RASGRP2 S391 ochoa RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}.
Q7RTP6 MICAL3 S1221 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q7Z406 MYH14 S221 ochoa Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.
Q7Z406 MYH14 S337 ochoa Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.
Q7Z6G8 ANKS1B S310 ochoa Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Q86WB0 ZC3HC1 S303 ochoa Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}.
Q8IVT2 MISP S156 ochoa Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Q8IW35 CEP97 S724 ochoa Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}.
Q8IWC1 MAP7D3 S234 ochoa MAP7 domain-containing protein 3 Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.
Q8N4C6 NIN S1970 ochoa Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}.
Q8N8S7 ENAH S486 ochoa Protein enabled homolog Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.
Q8NC44 RETREG2 S403 ochoa Reticulophagy regulator 2 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}.
Q8NDI1 EHBP1 T378 ochoa EH domain-binding protein 1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.
Q8NEM0 MCPH1 S438 ochoa Microcephalin Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}.
Q8TAP6 CEP76 S83 ochoa|psp Centrosomal protein of 76 kDa (Cep76) Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. {ECO:0000269|PubMed:19460342}.
Q8TD19 NEK9 S332 ochoa Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.
Q8TE77 SSH3 S87 ochoa Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}.
Q8WUU5 GATAD1 S235 ochoa GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein) Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). {ECO:0000269|PubMed:20850016}.
Q8WUY3 PRUNE2 S1789 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q8WWM7 ATXN2L S559 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WX93 PALLD S192 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q92558 WASF1 S104 ochoa Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}.
Q92576 PHF3 S1614 ochoa PHD finger protein 3 None
Q96GS4 BORCS6 S61 ochoa BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}.
Q96GU1 PAGE5 S31 ochoa P antigen family member 5 (PAGE-5) (Cancer/testis antigen 16.1) (CT16.1) (G antigen family E member 1) (Prostate-associated gene 5 protein) None
Q96JI7 SPG11 S1958 ochoa Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. {ECO:0000269|PubMed:24794856}.
Q96NR8 RDH12 S175 ochoa Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:15865448, PubMed:19686838). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:12226107, PubMed:15865448). {ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:19686838}.
Q96QB1 DLC1 S566 ochoa Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}.
Q96QT4 TRPM7 S1388 ochoa Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q99550 MPHOSPH9 S874 ochoa M-phase phosphoprotein 9 Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}.
Q9BR61 ACBD6 S106 ochoa Acyl-CoA-binding domain-containing protein 6 Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. Plays a role in protein N-myristoylation (PubMed:37951597). {ECO:0000269|PubMed:18268358, ECO:0000269|PubMed:37951597}.
Q9BTE3 MCMBP S223 ochoa Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}.
Q9BUB5 MKNK1 S437 ochoa MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}.
Q9BYW2 SETD2 S614 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9BYW2 SETD2 S1216 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9BZL4 PPP1R12C S325 ochoa Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}.
Q9H2G9 BLZF1 S284 ochoa Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}.
Q9H2G9 BLZF1 S353 ochoa Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}.
Q9H501 ESF1 S198 ochoa ESF1 homolog (ABT1-associated protein) May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9H5I1 SUV39H2 S382 ochoa Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126}.
Q9HC52 CBX8 S191 ochoa Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}.
Q9HCM4 EPB41L5 S550 ochoa Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.
Q9NP31 SH2D2A S217 ochoa SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Q9NPI6 DCP1A S142 ochoa mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}.
Q9NUQ3 TXLNG S97 ochoa Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. {ECO:0000269|PubMed:15911876, ECO:0000269|PubMed:18068885}.
Q9NVR0 KLHL11 S465 ochoa Kelch-like protein 11 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. {ECO:0000250}.
Q9P0L2 MARK1 S394 ochoa Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}.
Q9P1Y6 PHRF1 S568 ochoa PHD and RING finger domain-containing protein 1 None
Q9UBB6 NCDN S448 ochoa Neurochondrin Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). {ECO:0000269|PubMed:16945926, ECO:0000269|PubMed:33711248, ECO:0000305|PubMed:33711248}.
Q9UBU9 NXF1 S558 ochoa Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}.
Q9UER7 DAXX S403 ochoa Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}.
Q9UER7 DAXX S610 ochoa Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}.
Q9UGN5 PARP2 S34 ochoa Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:30104678, PubMed:32028527, PubMed:32939087, PubMed:34108479, PubMed:34486521, PubMed:34874266). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30104678, PubMed:30321391). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527, PubMed:34108479, PubMed:34486521, PubMed:34874266). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087, PubMed:34108479). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:34795260). Specifically mediates formation of branched poly-ADP-ribosylation (PubMed:30104678). Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (PubMed:30104678). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034, PubMed:29361132). {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29361132, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:34108479, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266}.
Q9ULH0 KIDINS220 S1718 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9UN79 SOX13 S453 ochoa Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}.
Q9UP83 COG5 S304 ochoa Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}.
Q9UPT6 MAPK8IP3 S365 ochoa|psp C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}.
Q9Y253 POLH S601 psp DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}.
Q9Y283 INVS S614 ochoa Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15852005, ECO:0000269|PubMed:18371931}.
Q9Y2I7 PIKFYVE S1549 ochoa 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}.
Q9Y6W5 WASF2 S103 ochoa Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}.
Q9Y6X4 FAM169A S527 ochoa Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) None
Q86TB9 PATL1 S564 Sugiyama Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}.
P35372 OPRM1 S358 SIGNOR Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.
P09497 CLTB S206 Sugiyama Clathrin light chain B (Lcb) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Download
reactome_id name p -log10_p
R-HSA-9673013 Diseases of Telomere Maintenance 0.019068 1.720
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.019068 1.720
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.019068 1.720
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.019068 1.720
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.019068 1.720
R-HSA-9918440 Defective visual phototransduction due to RDH12 loss of function 0.037775 1.423
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.046995 1.328
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.046995 1.328
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.056127 1.251
R-HSA-74713 IRS activation 0.065173 1.186
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.009422 2.026
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 0.074132 1.130
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.074132 1.130
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.083006 1.081
R-HSA-112412 SOS-mediated signalling 0.091795 1.037
R-HSA-9031528 NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... 0.091795 1.037
R-HSA-9031525 NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 0.091795 1.037
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 0.091795 1.037
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.017788 1.750
R-HSA-196025 Formation of annular gap junctions 0.100501 0.998
R-HSA-170984 ARMS-mediated activation 0.109124 0.962
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 0.109124 0.962
R-HSA-190873 Gap junction degradation 0.109124 0.962
R-HSA-390522 Striated Muscle Contraction 0.007046 2.152
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.134502 0.871
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.142801 0.845
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 0.151021 0.821
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.151021 0.821
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.159162 0.798
R-HSA-9603798 Class I peroxisomal membrane protein import 0.175213 0.756
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.031811 1.497
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.031811 1.497
R-HSA-110320 Translesion Synthesis by POLH 0.206408 0.685
R-HSA-8854518 AURKA Activation by TPX2 0.035284 1.452
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.044115 1.355
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.229031 0.640
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.229031 0.640
R-HSA-380287 Centrosome maturation 0.046821 1.330
R-HSA-383280 Nuclear Receptor transcription pathway 0.051031 1.292
R-HSA-429947 Deadenylation of mRNA 0.251014 0.600
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.067962 1.168
R-HSA-445095 Interaction between L1 and Ankyrins 0.272374 0.565
R-HSA-9615710 Late endosomal microautophagy 0.286277 0.543
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.313296 0.504
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.319890 0.495
R-HSA-5696400 Dual Incision in GG-NER 0.326421 0.486
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.358155 0.446
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.364321 0.439
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.364321 0.439
R-HSA-8957275 Post-translational protein phosphorylation 0.282388 0.549
R-HSA-1989781 PPARA activates gene expression 0.233146 0.632
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.335316 0.475
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.335316 0.475
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.238224 0.623
R-HSA-68962 Activation of the pre-replicative complex 0.047636 1.322
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.015887 1.799
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.265322 0.576
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.009562 2.019
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.008044 2.095
R-HSA-9646399 Aggrephagy 0.075898 1.120
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.085615 1.067
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.003996 2.398
R-HSA-9762292 Regulation of CDH11 function 0.117664 0.929
R-HSA-198203 PI3K/AKT activation 0.117664 0.929
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.126123 0.899
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.364321 0.439
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.183124 0.737
R-HSA-9609690 HCMV Early Events 0.154455 0.811
R-HSA-429914 Deadenylation-dependent mRNA decay 0.027476 1.561
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.073148 1.136
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.222113 0.653
R-HSA-202040 G-protein activation 0.221562 0.655
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.307183 0.513
R-HSA-5619507 Activation of HOX genes during differentiation 0.307183 0.513
R-HSA-9764302 Regulation of CDH19 Expression and Function 0.002801 2.553
R-HSA-9675126 Diseases of mitotic cell cycle 0.052426 1.280
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.057381 1.241
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.324799 0.488
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.078680 1.104
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.047636 1.322
R-HSA-212165 Epigenetic regulation of gene expression 0.236308 0.627
R-HSA-111446 Activation of BIM and translocation to mitochondria 0.046995 1.328
R-HSA-176974 Unwinding of DNA 0.006145 2.211
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.117664 0.929
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 0.134502 0.871
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.151021 0.821
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.198721 0.702
R-HSA-350054 Notch-HLH transcription pathway 0.236429 0.626
R-HSA-6807878 COPI-mediated anterograde transport 0.085275 1.069
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.319890 0.495
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.332890 0.478
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.339298 0.469
R-HSA-9613829 Chaperone Mediated Autophagy 0.198721 0.702
R-HSA-69002 DNA Replication Pre-Initiation 0.324799 0.488
R-HSA-5656169 Termination of translesion DNA synthesis 0.286277 0.543
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.331718 0.479
R-HSA-9909396 Circadian clock 0.171821 0.765
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.024590 1.609
R-HSA-74749 Signal attenuation 0.117664 0.929
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.190960 0.719
R-HSA-9620244 Long-term potentiation 0.258203 0.588
R-HSA-9609646 HCMV Infection 0.263011 0.580
R-HSA-9603381 Activated NTRK3 signals through PI3K 0.091795 1.037
R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.175213 0.756
R-HSA-6811438 Intra-Golgi traffic 0.081495 1.089
R-HSA-9707616 Heme signaling 0.146501 0.834
R-HSA-68877 Mitotic Prometaphase 0.149102 0.827
R-HSA-5696398 Nucleotide Excision Repair 0.310714 0.508
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.011952 1.923
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 0.142801 0.845
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.005694 2.245
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.166615 0.778
R-HSA-9675151 Disorders of Developmental Biology 0.017788 1.750
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.151021 0.821
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.054884 1.261
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.221562 0.655
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.059981 1.222
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.293129 0.533
R-HSA-69206 G1/S Transition 0.153305 0.814
R-HSA-169893 Prolonged ERK activation events 0.175213 0.756
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.275286 0.560
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.229031 0.640
R-HSA-68867 Assembly of the pre-replicative complex 0.261077 0.583
R-HSA-9842663 Signaling by LTK 0.142801 0.845
R-HSA-69052 Switching of origins to a post-replicative state 0.044115 1.355
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.195800 0.708
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.003522 2.453
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.286277 0.543
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.313296 0.504
R-HSA-1839124 FGFR1 mutant receptor activation 0.313296 0.504
R-HSA-5617833 Cilium Assembly 0.143823 0.842
R-HSA-69306 DNA Replication 0.228088 0.642
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.265322 0.576
R-HSA-9664407 Parasite infection 0.193365 0.714
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.193365 0.714
R-HSA-9664417 Leishmania phagocytosis 0.193365 0.714
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.134502 0.871
R-HSA-8866427 VLDLR internalisation and degradation 0.142801 0.845
R-HSA-1475029 Reversible hydration of carbon dioxide 0.151021 0.821
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.167226 0.777
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.229031 0.640
R-HSA-68949 Orc1 removal from chromatin 0.114303 0.942
R-HSA-3928663 EPHA-mediated growth cone collapse 0.272374 0.565
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.210565 0.677
R-HSA-68875 Mitotic Prophase 0.139867 0.854
R-HSA-9663891 Selective autophagy 0.239786 0.620
R-HSA-400685 Sema4D in semaphorin signaling 0.036430 1.439
R-HSA-3214841 PKMTs methylate histone lysines 0.001277 2.894
R-HSA-176187 Activation of ATR in response to replication stress 0.054884 1.261
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.035284 1.452
R-HSA-68886 M Phase 0.095823 1.019
R-HSA-8863795 Downregulation of ERBB2 signaling 0.293129 0.533
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.161705 0.791
R-HSA-199991 Membrane Trafficking 0.112909 0.947
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.005196 2.284
R-HSA-9697154 Disorders of Nervous System Development 0.142801 0.845
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.142801 0.845
R-HSA-9005895 Pervasive developmental disorders 0.142801 0.845
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.229031 0.640
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.313296 0.504
R-HSA-187687 Signalling to ERKs 0.332890 0.478
R-HSA-1852241 Organelle biogenesis and maintenance 0.111665 0.952
R-HSA-69239 Synthesis of DNA 0.108238 0.966
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.265322 0.576
R-HSA-5653656 Vesicle-mediated transport 0.277434 0.557
R-HSA-1251985 Nuclear signaling by ERBB4 0.364321 0.439
R-HSA-69278 Cell Cycle, Mitotic 0.058421 1.233
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.167226 0.777
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.167226 0.777
R-HSA-4641263 Regulation of FZD by ubiquitination 0.190960 0.719
R-HSA-69481 G2/M Checkpoints 0.157872 0.802
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.284647 0.546
R-HSA-5693532 DNA Double-Strand Break Repair 0.084237 1.074
R-HSA-69242 S Phase 0.215541 0.666
R-HSA-1640170 Cell Cycle 0.049955 1.301
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.258203 0.588
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.180277 0.744
R-HSA-199977 ER to Golgi Anterograde Transport 0.213049 0.672
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.046821 1.330
R-HSA-1538133 G0 and Early G1 0.306638 0.513
R-HSA-73894 DNA Repair 0.303828 0.517
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.043017 1.366
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.067749 1.169
R-HSA-392517 Rap1 signalling 0.206408 0.685
R-HSA-3295583 TRP channels 0.265322 0.576
R-HSA-69620 Cell Cycle Checkpoints 0.131821 0.880
R-HSA-69275 G2/M Transition 0.316029 0.500
R-HSA-69190 DNA strand elongation 0.052426 1.280
R-HSA-453274 Mitotic G2-G2/M phases 0.321273 0.493
R-HSA-166208 mTORC1-mediated signalling 0.236429 0.626
R-HSA-432720 Lysosome Vesicle Biogenesis 0.339298 0.469
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.303649 0.518
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.036847 1.434
R-HSA-397014 Muscle contraction 0.186085 0.730
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.306638 0.513
R-HSA-114508 Effects of PIP2 hydrolysis 0.319890 0.495
R-HSA-5693538 Homology Directed Repair 0.039532 1.403
R-HSA-3247509 Chromatin modifying enzymes 0.099979 1.000
R-HSA-2586552 Signaling by Leptin 0.117664 0.929
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.229031 0.640
R-HSA-194138 Signaling by VEGF 0.047225 1.326
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 0.243757 0.613
R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 0.332890 0.478
R-HSA-948021 Transport to the Golgi and subsequent modification 0.357953 0.446
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.229171 0.640
R-HSA-373760 L1CAM interactions 0.356201 0.448
R-HSA-1295596 Spry regulation of FGF signaling 0.167226 0.777
R-HSA-381042 PERK regulates gene expression 0.062491 1.204
R-HSA-1369062 ABC transporters in lipid homeostasis 0.243757 0.613
R-HSA-4839726 Chromatin organization 0.119385 0.923
R-HSA-418885 DCC mediated attractive signaling 0.167226 0.777
R-HSA-6807004 Negative regulation of MET activity 0.214021 0.670
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.126954 0.896
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.038579 1.414
R-HSA-373753 Nephrin family interactions 0.214021 0.670
R-HSA-2453864 Retinoid cycle disease events 0.258203 0.588
R-HSA-9733709 Cardiogenesis 0.313296 0.504
R-HSA-373755 Semaphorin interactions 0.149818 0.824
R-HSA-2474795 Diseases associated with visual transduction 0.258203 0.588
R-HSA-9675143 Diseases of the neuronal system 0.258203 0.588
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.279359 0.554
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.286277 0.543
R-HSA-9022692 Regulation of MECP2 expression and activity 0.313296 0.504
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.326421 0.486
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.345785 0.461
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.279440 0.554
R-HSA-201681 TCF dependent signaling in response to WNT 0.308168 0.511
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.313296 0.504
R-HSA-6804757 Regulation of TP53 Degradation 0.339298 0.469
R-HSA-389948 Co-inhibition by PD-1 0.352723 0.453
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.159428 0.797
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.342301 0.466
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.317765 0.498
R-HSA-1169408 ISG15 antiviral mechanism 0.190632 0.720
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.211562 0.675
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.175213 0.756
R-HSA-202433 Generation of second messenger molecules 0.364321 0.439
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.358155 0.446
R-HSA-9007101 Rab regulation of trafficking 0.359660 0.444
R-HSA-9700206 Signaling by ALK in cancer 0.317765 0.498
R-HSA-189200 Cellular hexose transport 0.236429 0.626
R-HSA-168638 NOD1/2 Signaling Pathway 0.326421 0.486
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.326421 0.486
R-HSA-1592230 Mitochondrial biogenesis 0.359660 0.444
R-HSA-1474244 Extracellular matrix organization 0.250559 0.601
R-HSA-114452 Activation of BH3-only proteins 0.293129 0.533
R-HSA-422475 Axon guidance 0.180733 0.743
R-HSA-9675108 Nervous system development 0.129155 0.889
R-HSA-201556 Signaling by ALK 0.358155 0.446
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.090118 1.045
R-HSA-9707564 Cytoprotection by HMOX1 0.218591 0.660
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.147334 0.832
R-HSA-354192 Integrin signaling 0.313296 0.504
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.345644 0.461
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.278838 0.555
R-HSA-1280218 Adaptive Immune System 0.228715 0.641
R-HSA-8986944 Transcriptional Regulation by MECP2 0.072971 1.137
R-HSA-1266695 Interleukin-7 signaling 0.258203 0.588
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.319890 0.495
R-HSA-982772 Growth hormone receptor signaling 0.243757 0.613
R-HSA-2682334 EPH-Ephrin signaling 0.257525 0.589
R-HSA-8964043 Plasma lipoprotein clearance 0.358155 0.446
R-HSA-195721 Signaling by WNT 0.366543 0.436
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.370428 0.431
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.370428 0.431
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.370428 0.431
R-HSA-5655302 Signaling by FGFR1 in disease 0.376477 0.424
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.376477 0.424
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.380267 0.420
R-HSA-2132295 MHC class II antigen presentation 0.380267 0.420
R-HSA-165159 MTOR signalling 0.382469 0.417
R-HSA-5654743 Signaling by FGFR4 0.388403 0.411
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.390467 0.408
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.390467 0.408
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.390467 0.408
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.394280 0.404
R-HSA-190828 Gap junction trafficking 0.394280 0.404
R-HSA-156581 Methylation 0.394280 0.404
R-HSA-69236 G1 Phase 0.394280 0.404
R-HSA-69231 Cyclin D associated events in G1 0.394280 0.404
R-HSA-3214858 RMTs methylate histone arginines 0.394280 0.404
R-HSA-373752 Netrin-1 signaling 0.394280 0.404
R-HSA-114608 Platelet degranulation 0.397226 0.401
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 0.400101 0.398
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.400101 0.398
R-HSA-5654741 Signaling by FGFR3 0.400101 0.398
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.400593 0.397
R-HSA-2299718 Condensation of Prophase Chromosomes 0.405867 0.392
R-HSA-8951664 Neddylation 0.409828 0.387
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.411578 0.386
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.411578 0.386
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.411578 0.386
R-HSA-437239 Recycling pathway of L1 0.411578 0.386
R-HSA-9843745 Adipogenesis 0.413972 0.383
R-HSA-5620924 Intraflagellar transport 0.417234 0.380
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.417234 0.380
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.417234 0.380
R-HSA-8856688 Golgi-to-ER retrograde transport 0.417294 0.380
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.420607 0.376
R-HSA-8878171 Transcriptional regulation by RUNX1 0.422620 0.374
R-HSA-73893 DNA Damage Bypass 0.422836 0.374
R-HSA-9766229 Degradation of CDH1 0.422836 0.374
R-HSA-157858 Gap junction trafficking and regulation 0.422836 0.374
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.422836 0.374
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.422836 0.374
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.422836 0.374
R-HSA-109704 PI3K Cascade 0.428385 0.368
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.439323 0.357
R-HSA-6794361 Neurexins and neuroligins 0.439323 0.357
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.439323 0.357
R-HSA-381119 Unfolded Protein Response (UPR) 0.443521 0.353
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.444714 0.352
R-HSA-445355 Smooth Muscle Contraction 0.444714 0.352
R-HSA-1632852 Macroautophagy 0.449977 0.347
R-HSA-72649 Translation initiation complex formation 0.450054 0.347
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.450054 0.347
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.455342 0.342
R-HSA-3214815 HDACs deacetylate histones 0.455342 0.342
R-HSA-8856828 Clathrin-mediated endocytosis 0.459581 0.338
R-HSA-72702 Ribosomal scanning and start codon recognition 0.460581 0.337
R-HSA-193648 NRAGE signals death through JNK 0.460581 0.337
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.460581 0.337
R-HSA-5654736 Signaling by FGFR1 0.460581 0.337
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.460581 0.337
R-HSA-112399 IRS-mediated signalling 0.465768 0.332
R-HSA-9764561 Regulation of CDH1 Function 0.465768 0.332
R-HSA-2980766 Nuclear Envelope Breakdown 0.465768 0.332
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.465768 0.332
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.470907 0.327
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.470907 0.327
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.475372 0.323
R-HSA-166520 Signaling by NTRKs 0.475372 0.323
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.475996 0.322
R-HSA-983189 Kinesins 0.481037 0.318
R-HSA-8943724 Regulation of PTEN gene transcription 0.481037 0.318
R-HSA-1227986 Signaling by ERBB2 0.481037 0.318
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.481037 0.318
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.481037 0.318
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.481037 0.318
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.481037 0.318
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.481037 0.318
R-HSA-9856651 MITF-M-dependent gene expression 0.481610 0.317
R-HSA-2428928 IRS-related events triggered by IGF1R 0.486029 0.313
R-HSA-450294 MAP kinase activation 0.486029 0.313
R-HSA-6798695 Neutrophil degranulation 0.488651 0.311
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.490974 0.309
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.490974 0.309
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.493951 0.306
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.495872 0.305
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.495872 0.305
R-HSA-69615 G1/S DNA Damage Checkpoints 0.495872 0.305
R-HSA-388841 Regulation of T cell activation by CD28 family 0.497103 0.304
R-HSA-9612973 Autophagy 0.500052 0.301
R-HSA-74751 Insulin receptor signalling cascade 0.500722 0.300
R-HSA-2428924 IGF1R signaling cascade 0.500722 0.300
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.500722 0.300
R-HSA-9006931 Signaling by Nuclear Receptors 0.504772 0.297
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.505526 0.296
R-HSA-9711097 Cellular response to starvation 0.506106 0.296
R-HSA-9006936 Signaling by TGFB family members 0.512112 0.291
R-HSA-5693606 DNA Double Strand Break Response 0.514998 0.288
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.514998 0.288
R-HSA-196807 Nicotinate metabolism 0.514998 0.288
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.519665 0.284
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.519665 0.284
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.519665 0.284
R-HSA-69202 Cyclin E associated events during G1/S transition 0.528868 0.277
R-HSA-448424 Interleukin-17 signaling 0.528868 0.277
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.533403 0.273
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.537894 0.269
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.537894 0.269
R-HSA-76002 Platelet activation, signaling and aggregation 0.539453 0.268
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.542343 0.266
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.542343 0.266
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.542343 0.266
R-HSA-69473 G2/M DNA damage checkpoint 0.546750 0.262
R-HSA-1236394 Signaling by ERBB4 0.546750 0.262
R-HSA-1226099 Signaling by FGFR in disease 0.546750 0.262
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.546760 0.262
R-HSA-8852135 Protein ubiquitination 0.551114 0.259
R-HSA-9824443 Parasitic Infection Pathways 0.555370 0.255
R-HSA-9658195 Leishmania infection 0.555370 0.255
R-HSA-5689603 UCH proteinases 0.555436 0.255
R-HSA-1980143 Signaling by NOTCH1 0.555436 0.255
R-HSA-162582 Signal Transduction 0.560820 0.251
R-HSA-4086400 PCP/CE pathway 0.563957 0.249
R-HSA-216083 Integrin cell surface interactions 0.563957 0.249
R-HSA-416482 G alpha (12/13) signalling events 0.563957 0.249
R-HSA-9659379 Sensory processing of sound 0.568156 0.246
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.568156 0.246
R-HSA-2559583 Cellular Senescence 0.572240 0.242
R-HSA-5654738 Signaling by FGFR2 0.572316 0.242
R-HSA-6806834 Signaling by MET 0.572316 0.242
R-HSA-5693607 Processing of DNA double-strand break ends 0.576435 0.239
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.580515 0.236
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.588559 0.230
R-HSA-6794362 Protein-protein interactions at synapses 0.592523 0.227
R-HSA-449147 Signaling by Interleukins 0.592546 0.227
R-HSA-141424 Amplification of signal from the kinetochores 0.596449 0.224
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.596449 0.224
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.600337 0.222
R-HSA-168898 Toll-like Receptor Cascades 0.601541 0.221
R-HSA-438064 Post NMDA receptor activation events 0.604188 0.219
R-HSA-390466 Chaperonin-mediated protein folding 0.604188 0.219
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.614354 0.212
R-HSA-73884 Base Excision Repair 0.615522 0.211
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.622898 0.206
R-HSA-74752 Signaling by Insulin receptor 0.626534 0.203
R-HSA-156842 Eukaryotic Translation Elongation 0.626534 0.203
R-HSA-391251 Protein folding 0.626534 0.203
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.626534 0.203
R-HSA-1500931 Cell-Cell communication 0.629866 0.201
R-HSA-376176 Signaling by ROBO receptors 0.631765 0.199
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.633700 0.198
R-HSA-1474290 Collagen formation 0.633700 0.198
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.637232 0.196
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.644194 0.191
R-HSA-157579 Telomere Maintenance 0.647625 0.189
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.651023 0.186
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.651023 0.186
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.651023 0.186
R-HSA-190236 Signaling by FGFR 0.651023 0.186
R-HSA-3214847 HATs acetylate histones 0.654389 0.184
R-HSA-193704 p75 NTR receptor-mediated signalling 0.654389 0.184
R-HSA-69618 Mitotic Spindle Checkpoint 0.657723 0.182
R-HSA-382556 ABC-family proteins mediated transport 0.657723 0.182
R-HSA-9730414 MITF-M-regulated melanocyte development 0.657885 0.182
R-HSA-597592 Post-translational protein modification 0.659197 0.181
R-HSA-9020702 Interleukin-1 signaling 0.661024 0.180
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.664294 0.178
R-HSA-1483255 PI Metabolism 0.664294 0.178
R-HSA-2559580 Oxidative Stress Induced Senescence 0.664294 0.178
R-HSA-418990 Adherens junctions interactions 0.669263 0.174
R-HSA-111885 Opioid Signalling 0.670740 0.173
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.670740 0.173
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.677063 0.169
R-HSA-9692914 SARS-CoV-1-host interactions 0.680179 0.167
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.686322 0.163
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.686322 0.163
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.686322 0.163
R-HSA-2672351 Stimuli-sensing channels 0.686322 0.163
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.689350 0.162
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.692348 0.160
R-HSA-166166 MyD88-independent TLR4 cascade 0.692348 0.160
R-HSA-202403 TCR signaling 0.692348 0.160
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.693225 0.159
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.701172 0.154
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.709744 0.149
R-HSA-72737 Cap-dependent Translation Initiation 0.715322 0.145
R-HSA-72613 Eukaryotic Translation Initiation 0.715322 0.145
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.720794 0.142
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.723491 0.141
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.723491 0.141
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.728807 0.137
R-HSA-73886 Chromosome Maintenance 0.728807 0.137
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.731427 0.136
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.731427 0.136
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.734022 0.134
R-HSA-421270 Cell-cell junction organization 0.736874 0.133
R-HSA-5688426 Deubiquitination 0.744221 0.128
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.753902 0.123
R-HSA-212436 Generic Transcription Pathway 0.756934 0.121
R-HSA-168256 Immune System 0.760061 0.119
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.761423 0.118
R-HSA-9711123 Cellular response to chemical stress 0.766904 0.115
R-HSA-3858494 Beta-catenin independent WNT signaling 0.772305 0.112
R-HSA-6807070 PTEN Regulation 0.778848 0.109
R-HSA-73857 RNA Polymerase II Transcription 0.779356 0.108
R-HSA-446728 Cell junction organization 0.783151 0.106
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.787282 0.104
R-HSA-2871837 FCERI mediated NF-kB activation 0.791378 0.102
R-HSA-2187338 Visual phototransduction 0.797377 0.098
R-HSA-1266738 Developmental Biology 0.798368 0.098
R-HSA-5673001 RAF/MAP kinase cascade 0.799876 0.097
R-HSA-446203 Asparagine N-linked glycosylation 0.802123 0.096
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.806995 0.093
R-HSA-446652 Interleukin-1 family signaling 0.806995 0.093
R-HSA-1257604 PIP3 activates AKT signaling 0.808511 0.092
R-HSA-9609507 Protein localization 0.808864 0.092
R-HSA-5684996 MAPK1/MAPK3 signaling 0.809918 0.092
R-HSA-73887 Death Receptor Signaling 0.810714 0.091
R-HSA-9610379 HCMV Late Events 0.816160 0.088
R-HSA-5633007 Regulation of TP53 Activity 0.821450 0.085
R-HSA-109581 Apoptosis 0.824892 0.084
R-HSA-2467813 Separation of Sister Chromatids 0.828268 0.082
R-HSA-2408522 Selenoamino acid metabolism 0.828268 0.082
R-HSA-1280215 Cytokine Signaling in Immune system 0.833923 0.079
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.844204 0.074
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.844204 0.074
R-HSA-5689880 Ub-specific processing proteases 0.844204 0.074
R-HSA-168249 Innate Immune System 0.845275 0.073
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.847210 0.072
R-HSA-9678108 SARS-CoV-1 Infection 0.847210 0.072
R-HSA-375276 Peptide ligand-binding receptors 0.862743 0.064
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.865394 0.063
R-HSA-9006925 Intracellular signaling by second messengers 0.865458 0.063
R-HSA-983712 Ion channel transport 0.866700 0.062
R-HSA-5683057 MAPK family signaling cascades 0.870509 0.060
R-HSA-74160 Gene expression (Transcription) 0.874455 0.058
R-HSA-2262752 Cellular responses to stress 0.878208 0.056
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.883718 0.054
R-HSA-5357801 Programmed Cell Death 0.887074 0.052
R-HSA-109582 Hemostasis 0.891180 0.050
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.894534 0.048
R-HSA-68882 Mitotic Anaphase 0.898575 0.046
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.899561 0.046
R-HSA-913531 Interferon Signaling 0.902815 0.044
R-HSA-9705683 SARS-CoV-2-host interactions 0.909798 0.041
R-HSA-392499 Metabolism of proteins 0.910718 0.041
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.911545 0.040
R-HSA-72312 rRNA processing 0.913258 0.039
R-HSA-202733 Cell surface interactions at the vascular wall 0.917398 0.037
R-HSA-156580 Phase II - Conjugation of compounds 0.918998 0.037
R-HSA-8953854 Metabolism of RNA 0.919036 0.037
R-HSA-418594 G alpha (i) signalling events 0.919591 0.036
R-HSA-157118 Signaling by NOTCH 0.919786 0.036
R-HSA-72766 Translation 0.932555 0.030
R-HSA-416476 G alpha (q) signalling events 0.936584 0.028
R-HSA-8953897 Cellular responses to stimuli 0.937163 0.028
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.945256 0.024
R-HSA-3700989 Transcriptional Regulation by TP53 0.949619 0.022
R-HSA-388396 GPCR downstream signalling 0.950581 0.022
R-HSA-112316 Neuronal System 0.950839 0.022
R-HSA-1483257 Phospholipid metabolism 0.953210 0.021
R-HSA-112315 Transmission across Chemical Synapses 0.964465 0.016
R-HSA-8957322 Metabolism of steroids 0.964812 0.016
R-HSA-372790 Signaling by GPCR 0.972017 0.012
R-HSA-9694516 SARS-CoV-2 Infection 0.972488 0.012
R-HSA-196854 Metabolism of vitamins and cofactors 0.976269 0.010
R-HSA-9824439 Bacterial Infection Pathways 0.981820 0.008
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.982525 0.008
R-HSA-425407 SLC-mediated transmembrane transport 0.983035 0.007
R-HSA-8978868 Fatty acid metabolism 0.984632 0.007
R-HSA-5663205 Infectious disease 0.987159 0.006
R-HSA-9824446 Viral Infection Pathways 0.987798 0.005
R-HSA-382551 Transport of small molecules 0.988558 0.005
R-HSA-211859 Biological oxidations 0.995140 0.002
R-HSA-9679506 SARS-CoV Infections 0.996468 0.002
R-HSA-500792 GPCR ligand binding 0.997485 0.001
R-HSA-71291 Metabolism of amino acids and derivatives 0.998119 0.001
R-HSA-1643685 Disease 0.998256 0.001
R-HSA-556833 Metabolism of lipids 0.999176 0.000
R-HSA-9709957 Sensory Perception 0.999953 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.851 0.414 1 0.810
KISKIS 0.849 0.559 1 0.913
HIPK2HIPK2 0.845 0.569 1 0.907
CDK7CDK7 0.844 0.573 1 0.929
CDK18CDK18 0.844 0.590 1 0.918
CDK19CDK19 0.841 0.565 1 0.926
CDK8CDK8 0.841 0.561 1 0.927
DYRK2DYRK2 0.840 0.548 1 0.894
CDK17CDK17 0.840 0.599 1 0.912
CDK1CDK1 0.839 0.582 1 0.925
JNK2JNK2 0.836 0.608 1 0.921
SRPK1SRPK1 0.836 0.289 -3 0.778
NLKNLK 0.835 0.517 1 0.818
P38GP38G 0.834 0.604 1 0.909
CDK3CDK3 0.834 0.537 1 0.916
CDK5CDK5 0.834 0.554 1 0.920
HIPK4HIPK4 0.834 0.362 1 0.802
CDK13CDK13 0.833 0.561 1 0.925
HIPK1HIPK1 0.833 0.516 1 0.889
CDK16CDK16 0.832 0.576 1 0.915
DYRK4DYRK4 0.831 0.557 1 0.922
CDK12CDK12 0.830 0.563 1 0.923
CDK10CDK10 0.830 0.552 1 0.917
JNK3JNK3 0.830 0.591 1 0.924
P38BP38B 0.829 0.582 1 0.887
ERK1ERK1 0.829 0.570 1 0.891
CDK14CDK14 0.829 0.568 1 0.912
CLK2CLK2 0.827 0.350 -3 0.770
P38DP38D 0.826 0.586 1 0.923
COTCOT 0.825 0.043 2 0.841
SRPK2SRPK2 0.825 0.232 -3 0.702
DYRK1BDYRK1B 0.824 0.524 1 0.907
CDK9CDK9 0.824 0.539 1 0.919
P38AP38A 0.823 0.548 1 0.878
DYRK1ADYRK1A 0.823 0.450 1 0.895
ICKICK 0.822 0.294 -3 0.853
CLK4CLK4 0.821 0.303 -3 0.788
CLK1CLK1 0.821 0.319 -3 0.769
ERK5ERK5 0.821 0.256 1 0.706
MOSMOS 0.821 0.168 1 0.615
ERK2ERK2 0.820 0.551 1 0.895
HIPK3HIPK3 0.819 0.486 1 0.856
CDKL1CDKL1 0.819 0.149 -3 0.816
NDR2NDR2 0.818 0.021 -3 0.862
PIM3PIM3 0.817 0.023 -3 0.851
CDKL5CDKL5 0.816 0.150 -3 0.814
MTORMTOR 0.815 0.076 1 0.637
DYRK3DYRK3 0.815 0.411 1 0.864
CDK2CDK2 0.814 0.422 1 0.884
PRKD1PRKD1 0.812 0.035 -3 0.849
GRK1GRK1 0.812 0.135 -2 0.763
PRPKPRPK 0.812 -0.071 -1 0.649
CDC7CDC7 0.812 -0.080 1 0.577
PRKD2PRKD2 0.812 0.055 -3 0.804
CDK4CDK4 0.812 0.551 1 0.927
SRPK3SRPK3 0.811 0.203 -3 0.741
MAKMAK 0.811 0.405 -2 0.779
CAMK1BCAMK1B 0.810 0.017 -3 0.856
JNK1JNK1 0.809 0.528 1 0.922
RSK2RSK2 0.809 0.038 -3 0.796
PRP4PRP4 0.808 0.357 -3 0.790
CDK6CDK6 0.808 0.527 1 0.910
PIM1PIM1 0.808 0.053 -3 0.803
PKN3PKN3 0.808 0.007 -3 0.841
NDR1NDR1 0.807 -0.007 -3 0.846
AURCAURC 0.807 0.056 -2 0.702
ATRATR 0.806 -0.029 1 0.597
SKMLCKSKMLCK 0.806 0.001 -2 0.855
CAMLCKCAMLCK 0.805 0.031 -2 0.841
P90RSKP90RSK 0.803 0.015 -3 0.800
WNK1WNK1 0.803 -0.060 -2 0.857
BMPR2BMPR2 0.802 -0.162 -2 0.836
PKACGPKACG 0.802 0.019 -2 0.771
MST4MST4 0.802 -0.020 2 0.800
RAF1RAF1 0.802 -0.177 1 0.536
IKKBIKKB 0.801 -0.135 -2 0.689
P70S6KBP70S6KB 0.801 0.025 -3 0.806
NIKNIK 0.801 -0.054 -3 0.864
PKACBPKACB 0.800 0.068 -2 0.720
PKN2PKN2 0.800 -0.020 -3 0.842
CAMK2GCAMK2G 0.800 -0.066 2 0.774
PKCDPKCD 0.800 -0.015 2 0.733
RSK3RSK3 0.800 0.001 -3 0.786
DAPK2DAPK2 0.800 -0.004 -3 0.864
NUAK2NUAK2 0.799 -0.014 -3 0.857
PRKXPRKX 0.799 0.089 -3 0.732
TBK1TBK1 0.799 -0.175 1 0.456
LATS2LATS2 0.799 -0.041 -5 0.730
MAPKAPK2MAPKAPK2 0.799 0.016 -3 0.759
PDHK4PDHK4 0.799 -0.248 1 0.595
RIPK3RIPK3 0.798 -0.089 3 0.757
MAPKAPK3MAPKAPK3 0.798 -0.020 -3 0.798
CHAK2CHAK2 0.798 -0.058 -1 0.616
NEK6NEK6 0.798 -0.097 -2 0.804
DSTYKDSTYK 0.797 -0.143 2 0.845
MOKMOK 0.797 0.358 1 0.799
ULK2ULK2 0.797 -0.212 2 0.756
TGFBR2TGFBR2 0.797 -0.093 -2 0.746
RSK4RSK4 0.796 0.045 -3 0.780
AMPKA1AMPKA1 0.796 -0.056 -3 0.864
LATS1LATS1 0.796 0.049 -3 0.867
PRKD3PRKD3 0.796 0.030 -3 0.769
GCN2GCN2 0.796 -0.213 2 0.758
PKG2PKG2 0.795 0.046 -2 0.725
IKKEIKKE 0.795 -0.171 1 0.449
IKKAIKKA 0.793 -0.075 -2 0.674
PAK1PAK1 0.793 -0.018 -2 0.804
NEK7NEK7 0.793 -0.186 -3 0.826
AURBAURB 0.793 0.024 -2 0.694
MNK2MNK2 0.793 -0.016 -2 0.795
AMPKA2AMPKA2 0.792 -0.041 -3 0.838
MLK1MLK1 0.792 -0.135 2 0.765
GRK5GRK5 0.792 -0.167 -3 0.825
AKT2AKT2 0.791 0.058 -3 0.724
TSSK1TSSK1 0.791 -0.049 -3 0.880
PAK6PAK6 0.790 0.021 -2 0.711
PAK3PAK3 0.790 -0.049 -2 0.792
TSSK2TSSK2 0.790 -0.067 -5 0.825
MSK2MSK2 0.790 -0.012 -3 0.767
PDHK1PDHK1 0.790 -0.263 1 0.567
DLKDLK 0.790 -0.127 1 0.553
BMPR1BBMPR1B 0.789 -0.013 1 0.522
PKCBPKCB 0.789 -0.028 2 0.680
HUNKHUNK 0.789 -0.165 2 0.791
WNK3WNK3 0.789 -0.214 1 0.528
GRK7GRK7 0.789 0.015 1 0.533
CAMK4CAMK4 0.789 -0.074 -3 0.825
MNK1MNK1 0.788 -0.009 -2 0.803
CAMK2DCAMK2D 0.788 -0.101 -3 0.842
ULK1ULK1 0.788 -0.194 -3 0.791
MARK4MARK4 0.788 -0.119 4 0.788
MSK1MSK1 0.788 0.017 -3 0.770
GRK6GRK6 0.787 -0.105 1 0.553
PKCGPKCG 0.787 -0.036 2 0.675
MYLK4MYLK4 0.787 0.009 -2 0.786
MLK2MLK2 0.787 -0.131 2 0.778
RIPK1RIPK1 0.787 -0.173 1 0.517
CAMK2BCAMK2B 0.786 -0.030 2 0.748
TGFBR1TGFBR1 0.786 -0.032 -2 0.740
GSK3AGSK3A 0.786 0.171 4 0.513
MASTLMASTL 0.786 -0.200 -2 0.762
PIM2PIM2 0.786 0.036 -3 0.771
CAMK2ACAMK2A 0.786 -0.012 2 0.751
PKCAPKCA 0.786 -0.033 2 0.672
IRE1IRE1 0.785 -0.119 1 0.516
SGK3SGK3 0.785 0.010 -3 0.794
ATMATM 0.785 -0.070 1 0.549
MELKMELK 0.785 -0.066 -3 0.818
NUAK1NUAK1 0.785 -0.049 -3 0.802
VRK2VRK2 0.785 -0.025 1 0.635
FAM20CFAM20C 0.784 0.006 2 0.618
ALK4ALK4 0.784 -0.068 -2 0.768
MLK3MLK3 0.784 -0.068 2 0.681
PKRPKR 0.784 -0.089 1 0.560
AURAAURA 0.784 0.011 -2 0.665
NIM1NIM1 0.783 -0.124 3 0.809
BCKDKBCKDK 0.783 -0.199 -1 0.563
GRK4GRK4 0.782 -0.155 -2 0.788
ACVR2BACVR2B 0.782 -0.015 -2 0.744
NEK9NEK9 0.782 -0.238 2 0.801
PHKG1PHKG1 0.782 -0.069 -3 0.833
PKCZPKCZ 0.782 -0.068 2 0.733
PKACAPKACA 0.781 0.044 -2 0.678
ANKRD3ANKRD3 0.781 -0.171 1 0.552
PAK2PAK2 0.781 -0.058 -2 0.780
PKCHPKCH 0.781 -0.062 2 0.670
MPSK1MPSK1 0.781 0.032 1 0.554
ERK7ERK7 0.781 0.152 2 0.483
IRE2IRE2 0.780 -0.110 2 0.714
ACVR2AACVR2A 0.780 -0.048 -2 0.732
DNAPKDNAPK 0.779 -0.051 1 0.505
PLK1PLK1 0.779 -0.111 -2 0.765
QSKQSK 0.778 -0.077 4 0.765
AKT1AKT1 0.777 0.031 -3 0.744
QIKQIK 0.777 -0.129 -3 0.840
SIKSIK 0.777 -0.068 -3 0.777
PASKPASK 0.777 0.023 -3 0.873
GSK3BGSK3B 0.776 0.063 4 0.506
CHAK1CHAK1 0.776 -0.158 2 0.752
CHK1CHK1 0.776 -0.071 -3 0.830
ALK2ALK2 0.776 -0.064 -2 0.750
MEK1MEK1 0.776 -0.173 2 0.795
SMG1SMG1 0.776 -0.104 1 0.564
TTBK2TTBK2 0.776 -0.214 2 0.669
CAMK1GCAMK1G 0.775 -0.027 -3 0.770
MLK4MLK4 0.774 -0.120 2 0.669
DCAMKL1DCAMKL1 0.774 -0.050 -3 0.809
CK1ECK1E 0.774 0.006 -3 0.545
GRK2GRK2 0.774 -0.064 -2 0.679
YSK4YSK4 0.773 -0.183 1 0.486
SMMLCKSMMLCK 0.773 -0.006 -3 0.821
NEK2NEK2 0.773 -0.190 2 0.769
MST3MST3 0.772 -0.042 2 0.786
PINK1PINK1 0.772 -0.001 1 0.696
BUB1BUB1 0.772 0.085 -5 0.797
BRSK1BRSK1 0.772 -0.085 -3 0.805
TLK2TLK2 0.772 -0.156 1 0.533
MAPKAPK5MAPKAPK5 0.771 -0.080 -3 0.729
DRAK1DRAK1 0.771 -0.111 1 0.496
PKCTPKCT 0.771 -0.059 2 0.681
WNK4WNK4 0.770 -0.138 -2 0.833
P70S6KP70S6K 0.770 -0.021 -3 0.728
SSTKSSTK 0.770 -0.053 4 0.756
PAK5PAK5 0.770 -0.018 -2 0.651
BMPR1ABMPR1A 0.769 -0.045 1 0.512
AKT3AKT3 0.769 0.046 -3 0.674
IRAK4IRAK4 0.769 -0.146 1 0.502
DAPK3DAPK3 0.769 0.014 -3 0.814
BRSK2BRSK2 0.769 -0.128 -3 0.822
PAK4PAK4 0.768 -0.004 -2 0.661
PLK4PLK4 0.768 -0.143 2 0.601
GAKGAK 0.768 0.002 1 0.569
CK1DCK1D 0.768 0.019 -3 0.497
TAO3TAO3 0.767 -0.073 1 0.537
SGK1SGK1 0.767 0.054 -3 0.653
PKCEPKCE 0.767 -0.002 2 0.664
MARK3MARK3 0.767 -0.104 4 0.708
MEK5MEK5 0.767 -0.195 2 0.785
BRAFBRAF 0.767 -0.167 -4 0.805
SNRKSNRK 0.767 -0.155 2 0.651
CAMK1DCAMK1D 0.766 -0.017 -3 0.716
DCAMKL2DCAMKL2 0.765 -0.067 -3 0.821
PERKPERK 0.765 -0.196 -2 0.770
CK1A2CK1A2 0.764 0.012 -3 0.498
MARK2MARK2 0.764 -0.121 4 0.667
MEKK3MEKK3 0.764 -0.157 1 0.519
ZAKZAK 0.764 -0.186 1 0.502
PHKG2PHKG2 0.764 -0.079 -3 0.804
MRCKAMRCKA 0.764 0.020 -3 0.771
MEKK1MEKK1 0.764 -0.200 1 0.533
NEK5NEK5 0.764 -0.198 1 0.528
PKCIPKCI 0.763 -0.058 2 0.690
HRIHRI 0.763 -0.214 -2 0.793
MRCKBMRCKB 0.763 0.024 -3 0.761
PLK3PLK3 0.763 -0.166 2 0.737
ROCK2ROCK2 0.763 0.021 -3 0.812
LKB1LKB1 0.763 -0.093 -3 0.830
DAPK1DAPK1 0.763 0.014 -3 0.801
SBKSBK 0.762 0.092 -3 0.611
MEKK2MEKK2 0.762 -0.168 2 0.763
MARK1MARK1 0.759 -0.135 4 0.737
GRK3GRK3 0.759 -0.063 -2 0.638
CK2A2CK2A2 0.759 -0.014 1 0.488
DMPK1DMPK1 0.759 0.062 -3 0.779
TAO2TAO2 0.759 -0.106 2 0.804
TLK1TLK1 0.758 -0.192 -2 0.784
NEK11NEK11 0.758 -0.157 1 0.522
PKN1PKN1 0.757 -0.038 -3 0.748
PDK1PDK1 0.757 -0.106 1 0.532
GCKGCK 0.756 -0.088 1 0.518
CHK2CHK2 0.756 -0.008 -3 0.672
HASPINHASPIN 0.755 -0.005 -1 0.506
CAMK1ACAMK1A 0.755 -0.008 -3 0.687
NEK8NEK8 0.755 -0.201 2 0.777
CAMKK1CAMKK1 0.754 -0.218 -2 0.697
TNIKTNIK 0.754 -0.080 3 0.908
MAP3K15MAP3K15 0.753 -0.133 1 0.495
MEKK6MEKK6 0.753 -0.145 1 0.508
PKG1PKG1 0.753 -0.000 -2 0.654
IRAK1IRAK1 0.752 -0.241 -1 0.556
HGKHGK 0.752 -0.120 3 0.908
CAMKK2CAMKK2 0.752 -0.185 -2 0.691
CRIKCRIK 0.751 0.032 -3 0.749
LRRK2LRRK2 0.751 -0.115 2 0.805
HPK1HPK1 0.751 -0.092 1 0.501
CK2A1CK2A1 0.751 -0.011 1 0.472
LOKLOK 0.751 -0.111 -2 0.732
CK1G1CK1G1 0.751 -0.095 -3 0.524
EEF2KEEF2K 0.751 -0.104 3 0.871
TAK1TAK1 0.751 -0.143 1 0.531
VRK1VRK1 0.751 -0.154 2 0.817
MINKMINK 0.750 -0.141 1 0.491
PDHK3_TYRPDHK3_TYR 0.748 0.203 4 0.903
NEK4NEK4 0.748 -0.223 1 0.495
PBKPBK 0.748 -0.067 1 0.503
KHS2KHS2 0.748 -0.052 1 0.511
KHS1KHS1 0.748 -0.084 1 0.493
MST2MST2 0.748 -0.158 1 0.513
ROCK1ROCK1 0.748 0.006 -3 0.771
TTBK1TTBK1 0.747 -0.209 2 0.593
SLKSLK 0.746 -0.107 -2 0.670
NEK1NEK1 0.745 -0.208 1 0.498
STK33STK33 0.741 -0.166 2 0.571
YSK1YSK1 0.741 -0.152 2 0.766
MST1MST1 0.740 -0.179 1 0.495
RIPK2RIPK2 0.740 -0.220 1 0.467
BMPR2_TYRBMPR2_TYR 0.740 0.240 -1 0.747
PDHK4_TYRPDHK4_TYR 0.740 0.143 2 0.843
PLK2PLK2 0.739 -0.101 -3 0.714
TESK1_TYRTESK1_TYR 0.739 0.068 3 0.920
BIKEBIKE 0.738 -0.043 1 0.488
OSR1OSR1 0.738 -0.082 2 0.747
LIMK2_TYRLIMK2_TYR 0.737 0.080 -3 0.876
PKMYT1_TYRPKMYT1_TYR 0.736 0.078 3 0.881
TTKTTK 0.735 -0.097 -2 0.783
MAP2K6_TYRMAP2K6_TYR 0.735 0.073 -1 0.676
ALPHAK3ALPHAK3 0.735 -0.059 -1 0.617
MAP2K4_TYRMAP2K4_TYR 0.733 -0.009 -1 0.657
MEK2MEK2 0.733 -0.284 2 0.775
PDHK1_TYRPDHK1_TYR 0.732 0.055 -1 0.705
EPHA6EPHA6 0.731 0.097 -1 0.730
NEK3NEK3 0.731 -0.211 1 0.489
MAP2K7_TYRMAP2K7_TYR 0.730 -0.084 2 0.827
MYO3BMYO3B 0.729 -0.120 2 0.775
ASK1ASK1 0.729 -0.164 1 0.492
PINK1_TYRPINK1_TYR 0.729 -0.051 1 0.587
TXKTXK 0.729 0.055 1 0.542
AAK1AAK1 0.728 -0.014 1 0.430
MYO3AMYO3A 0.725 -0.129 1 0.511
EPHB4EPHB4 0.725 -0.012 -1 0.662
YANK3YANK3 0.725 -0.071 2 0.363
TAO1TAO1 0.725 -0.140 1 0.471
RETRET 0.725 -0.100 1 0.532
LCKLCK 0.723 0.093 -1 0.738
CK1ACK1A 0.723 -0.039 -3 0.406
LIMK1_TYRLIMK1_TYR 0.722 -0.083 2 0.822
MST1RMST1R 0.721 -0.073 3 0.854
JAK3JAK3 0.720 0.003 1 0.522
JAK2JAK2 0.719 -0.090 1 0.529
ABL2ABL2 0.719 -0.061 -1 0.620
TYRO3TYRO3 0.718 -0.151 3 0.849
TYK2TYK2 0.718 -0.170 1 0.518
BLKBLK 0.718 0.066 -1 0.740
YES1YES1 0.718 -0.064 -1 0.666
HCKHCK 0.718 0.016 -1 0.714
ITKITK 0.717 -0.025 -1 0.661
CSF1RCSF1R 0.717 -0.089 3 0.822
ROS1ROS1 0.717 -0.135 3 0.810
BMXBMX 0.716 -0.019 -1 0.621
FYNFYN 0.714 0.103 -1 0.766
EPHA4EPHA4 0.714 -0.013 2 0.736
FGFR2FGFR2 0.714 -0.044 3 0.825
ABL1ABL1 0.714 -0.090 -1 0.609
INSRRINSRR 0.714 -0.061 3 0.786
TNK2TNK2 0.713 -0.112 3 0.793
EPHB1EPHB1 0.713 -0.065 1 0.528
FERFER 0.713 -0.143 1 0.562
DDR1DDR1 0.713 -0.155 4 0.793
FGRFGR 0.712 -0.128 1 0.532
EPHB3EPHB3 0.712 -0.062 -1 0.655
STLK3STLK3 0.712 -0.204 1 0.481
KDRKDR 0.712 -0.039 3 0.784
SRMSSRMS 0.711 -0.107 1 0.537
EPHB2EPHB2 0.711 -0.048 -1 0.657
METMET 0.711 -0.012 3 0.833
NEK10_TYRNEK10_TYR 0.711 -0.123 1 0.450
TEKTEK 0.710 -0.032 3 0.775
KITKIT 0.709 -0.090 3 0.827
TNK1TNK1 0.709 -0.119 3 0.821
PTK2PTK2 0.709 0.156 -1 0.787
FGFR1FGFR1 0.709 -0.081 3 0.803
JAK1JAK1 0.708 -0.105 1 0.474
TECTEC 0.707 -0.107 -1 0.585
TNNI3K_TYRTNNI3K_TYR 0.707 -0.106 1 0.555
FLT3FLT3 0.707 -0.145 3 0.841
WEE1_TYRWEE1_TYR 0.707 -0.084 -1 0.566
MERTKMERTK 0.706 -0.138 3 0.807
FLT1FLT1 0.705 -0.021 -1 0.693
EPHA7EPHA7 0.705 -0.036 2 0.738
AXLAXL 0.705 -0.177 3 0.810
SYKSYK 0.705 0.116 -1 0.745
PDGFRBPDGFRB 0.704 -0.202 3 0.848
FRKFRK 0.704 -0.038 -1 0.706
DDR2DDR2 0.704 -0.034 3 0.768
FGFR3FGFR3 0.702 -0.052 3 0.799
BTKBTK 0.702 -0.181 -1 0.600
EPHA1EPHA1 0.701 -0.089 3 0.811
EPHA8EPHA8 0.701 0.012 -1 0.712
EPHA3EPHA3 0.700 -0.078 2 0.712
LYNLYN 0.700 -0.036 3 0.739
ERBB2ERBB2 0.700 -0.094 1 0.499
ALKALK 0.698 -0.162 3 0.764
EPHA5EPHA5 0.697 -0.061 2 0.723
PDGFRAPDGFRA 0.697 -0.229 3 0.845
SRCSRC 0.697 -0.032 -1 0.709
PTK2BPTK2B 0.697 -0.099 -1 0.593
EGFREGFR 0.696 -0.064 1 0.442
LTKLTK 0.695 -0.179 3 0.775
MATKMATK 0.695 -0.117 -1 0.558
PTK6PTK6 0.695 -0.231 -1 0.550
CK1G3CK1G3 0.694 -0.074 -3 0.362
FLT4FLT4 0.694 -0.138 3 0.764
INSRINSR 0.693 -0.147 3 0.763
ERBB4ERBB4 0.692 0.018 1 0.460
NTRK1NTRK1 0.691 -0.223 -1 0.606
EPHA2EPHA2 0.691 -0.002 -1 0.678
ZAP70ZAP70 0.691 0.051 -1 0.669
NTRK3NTRK3 0.690 -0.163 -1 0.574
NTRK2NTRK2 0.689 -0.228 3 0.789
YANK2YANK2 0.688 -0.098 2 0.375
CK1G2CK1G2 0.688 -0.008 -3 0.448
CSKCSK 0.688 -0.145 2 0.744
FGFR4FGFR4 0.687 -0.109 -1 0.595
MUSKMUSK 0.686 -0.114 1 0.413
IGF1RIGF1R 0.680 -0.107 3 0.703
FESFES 0.672 -0.122 -1 0.583