Motif 741 (n=149)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4D2H0 | CTAGE15 | S656 | ochoa | cTAGE family member 15 (Protein cTAGE-15) | None |
| H3BQZ7 | HNRNPUL2-BSCL2 | S193 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O14733 | MAP2K7 | S35 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14950 | MYL12B | T128 | ochoa | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. {ECO:0000269|PubMed:10965042}. |
| O15240 | VGF | S199 | ochoa | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M.luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}. |
| O43156 | TTI1 | S106 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43166 | SIPA1L1 | S162 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43566 | RGS14 | S132 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O43815 | STRN | S239 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60271 | SPAG9 | S190 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60271 | SPAG9 | S251 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60271 | SPAG9 | S339 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75683 | SURF6 | S138 | ochoa | Surfeit locus protein 6 | Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}. |
| O95359 | TACC2 | S2256 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95613 | PCNT | S2327 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P00533 | EGFR | S991 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P10275 | AR | S96 | ochoa|psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P18031 | PTPN1 | S352 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P19105 | MYL12A | T127 | ochoa | Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}. |
| P21127 | CDK11B | S65 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P22626 | HNRNPA2B1 | S149 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23193 | TCEA1 | S107 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P29374 | ARID4A | S932 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30304 | CDC25A | S321 | ochoa|psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P32004 | L1CAM | S1190 | ochoa | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P36873 | PPP1CC | S182 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
| P39880 | CUX1 | S1321 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41250 | GARS1 | S651 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P42166 | TMPO | S166 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P46459 | NSF | S483 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P48681 | NES | S842 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49756 | RBM25 | S516 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P49810 | PSEN2 | S25 | ochoa | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}. |
| P51531 | SMARCA2 | S1377 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51957 | NEK4 | S563 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P52756 | RBM5 | S59 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
| P53350 | PLK1 | S383 | ochoa|psp | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P54132 | BLM | S367 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55957 | BID | S67 | ochoa|psp | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P60520 | GABARAPL2 | S88 | psp | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein) | Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295). {ECO:0000250|UniProtKB:P60519, ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295}. |
| P61970 | NUTF2 | S57 | ochoa | Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) | Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}. |
| P62136 | PPP1CA | S182 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62140 | PPP1CB | S181 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| P78332 | RBM6 | S353 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P82094 | TMF1 | S243 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q00587 | CDC42EP1 | S371 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q03188 | CENPC | S290 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q12888 | TP53BP1 | S176 | psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12912 | IRAG2 | S140 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13017 | ARHGAP5 | S968 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13045 | FLII | S856 | ochoa | Protein flightless-1 homolog | Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling. {ECO:0000250|UniProtKB:Q9JJ28, ECO:0000269|PubMed:14966289}. |
| Q13563 | PKD2 | S802 | ochoa | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q14191 | WRN | S426 | ochoa|psp | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14515 | SPARCL1 | S151 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
| Q14653 | IRF3 | S123 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14692 | BMS1 | S625 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q14790 | CASP8 | S387 | ochoa|psp | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| Q15149 | PLEC | S1435 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15398 | DLGAP5 | S720 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15464 | SHB | S317 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15746 | MYLK | S1848 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16623 | STX1A | S64 | ochoa | Syntaxin-1A (Neuron-specific antigen HPC-1) | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}. |
| Q16630 | CPSF6 | S38 | ochoa | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:21295486, PubMed:29276085). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}. |
| Q1KMD3 | HNRNPUL2 | S193 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2KHM9 | KIAA0753 | S826 | ochoa | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}. |
| Q2TAZ0 | ATG2A | S775 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q4G163 | FBXO43 | S121 | ochoa | F-box only protein 43 (Endogenous meiotic inhibitor 2) | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}. |
| Q53T59 | HS1BP3 | S139 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5T0W9 | FAM83B | S334 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T200 | ZC3H13 | S1455 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5Y3 | CAMSAP1 | S1239 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5T7B8 | KIF24 | S997 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5T8D3 | ACBD5 | S180 | ochoa | Acyl-CoA-binding domain-containing protein 5 | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}. |
| Q5VUB5 | FAM171A1 | S849 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VV67 | PPRC1 | S548 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q5VZ89 | DENND4C | S1225 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5VZE5 | NAA35 | S187 | ochoa | N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein homolog) (Protein MAK10 homolog) | Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Involved in regulation of apoptosis and proliferation of smooth muscle cells (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q5XKK7 | FAM219B | S133 | ochoa | Protein FAM219B | None |
| Q6GQQ9 | OTUD7B | S57 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6IQ19 | CCSAP | S145 | ochoa | Centriole, cilia and spindle-associated protein | Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6P3G4, ECO:0000269|PubMed:26562023}. |
| Q6IQ23 | PLEKHA7 | S983 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6IQ55 | TTBK2 | S371 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6KC79 | NIPBL | S1736 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6KC79 | NIPBL | S2658 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P5Q4 | LMOD2 | S186 | ochoa | Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin) | Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). {ECO:0000250|UniProtKB:Q3UHZ5, ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:25250574, ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:26417072}. |
| Q6PKG0 | LARP1 | S591 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6XZF7 | DNMBP | S689 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q86UF2 | CTAGE6 | S656 | ochoa | cTAGE family member 6 (Protein cTAGE-6) | None |
| Q86XL3 | ANKLE2 | S630 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YC2 | PALB2 | S660 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IUY3 | GRAMD2A | S27 | ochoa | GRAM domain-containing protein 2A | Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). {ECO:0000269|PubMed:29469807}. |
| Q8IY81 | FTSJ3 | S448 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8N5S9 | CAMKK1 | S100 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8NDI1 | EHBP1 | S177 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NHZ8 | CDC26 | S52 | ochoa | Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). May recruit the E2 ubiquitin-conjugating enzymes to the complex (PubMed:18485873). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q8TF44 | C2CD4C | S178 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WWQ0 | PHIP | S1274 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WYP5 | AHCTF1 | S1343 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WYP5 | AHCTF1 | S1371 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WYQ5 | DGCR8 | S377 | ochoa|psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92667 | AKAP1 | S553 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92844 | TANK | S129 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q93009 | USP7 | S963 | ochoa | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}. |
| Q96B36 | AKT1S1 | S221 | psp | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}. |
| Q96JB2 | COG3 | S511 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96JQ2 | CLMN | S841 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
| Q96LB3 | IFT74 | S300 | ochoa | Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) | Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:33689014}. |
| Q96PC5 | MIA2 | S1262 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96RT6 | CTAGE1 | S623 | ochoa | cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) | None |
| Q96T23 | RSF1 | S604 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q9BYW2 | SETD2 | S1216 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZF1 | OSBPL8 | S65 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C0K0 | BCL11B | S129 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9GZY8 | MFF | S263 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H2P0 | ADNP | S1067 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H334 | FOXP1 | S658 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H3D4 | TP63 | S68 | psp | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9HC77 | CPAP | S589 | psp | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NQS7 | INCENP | S446 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NRR4 | DROSHA | S355 | ochoa|psp | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) | Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q9NS73 | MBIP | S91 | ochoa | MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) | Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}. |
| Q9NUQ3 | TXLNG | S97 | ochoa | Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) | May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. {ECO:0000269|PubMed:15911876, ECO:0000269|PubMed:18068885}. |
| Q9UDY2 | TJP2 | S913 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9ULD4 | BRPF3 | S713 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9UMS5 | PHTF1 | S433 | ochoa | Protein PHTF1 | None |
| Q9UMS6 | SYNPO2 | S263 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UNN5 | FAF1 | S291 | psp | FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) | Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}. |
| Q9UPQ0 | LIMCH1 | S169 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ35 | SRRM2 | S1034 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ88 | CDK11A | S65 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2H5 | PLEKHA6 | S197 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2H5 | PLEKHA6 | S961 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2I7 | PIKFYVE | S493 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y3B9 | RRP15 | S51 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y5Q9 | GTF3C3 | S61 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| Q9Y6R1 | SLC4A4 | S86 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q15398 | DLGAP5 | S446 | Sugiyama | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q99816 | TSG101 | S232 | Sugiyama | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q9NY33 | DPP3 | S190 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| Q9Y6G9 | DYNC1LI1 | S381 | Sugiyama | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}. |
| Q7KZF4 | SND1 | S727 | Sugiyama | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| P52907 | CAPZA1 | S119 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| Q07157 | TJP1 | S585 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q9NSE4 | IARS2 | S98 | Sugiyama | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile)). {ECO:0000250|UniProtKB:P00956}. |
| Q9HAS0 | C17orf75 | S42 | Sugiyama | Protein Njmu-R1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. {ECO:0000269|PubMed:29426865}. |
| P24844 | MYL9 | T128 | Sugiyama | Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250|UniProtKB:Q9CQ19, ECO:0000269|PubMed:11942626, ECO:0000269|PubMed:2526655}. |
| Q96CU9 | FOXRED1 | S357 | Sugiyama | FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) | Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}. |
| O43242 | PSMD3 | S450 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q9UHD2 | TBK1 | S247 | Sugiyama | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 0.000002 | 5.788 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000010 | 5.003 |
| R-HSA-69275 | G2/M Transition | 0.000055 | 4.257 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.000060 | 4.222 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.000033 | 4.487 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.000101 | 3.997 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.000160 | 3.795 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.000179 | 3.747 |
| R-HSA-68882 | Mitotic Anaphase | 0.000173 | 3.761 |
| R-HSA-68886 | M Phase | 0.000276 | 3.560 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.000444 | 3.352 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.000444 | 3.352 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.000492 | 3.308 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.000522 | 3.283 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.000612 | 3.213 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.000628 | 3.202 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000667 | 3.176 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.000803 | 3.095 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.001369 | 2.864 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.001545 | 2.811 |
| R-HSA-380287 | Centrosome maturation | 0.001718 | 2.765 |
| R-HSA-68877 | Mitotic Prometaphase | 0.001607 | 2.794 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.001616 | 2.792 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.001998 | 2.699 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.002242 | 2.649 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.002242 | 2.649 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.002242 | 2.649 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.002242 | 2.649 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.002410 | 2.618 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.002503 | 2.602 |
| R-HSA-75153 | Apoptotic execution phase | 0.002400 | 2.620 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.002562 | 2.591 |
| R-HSA-109581 | Apoptosis | 0.002645 | 2.577 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.002777 | 2.556 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.003080 | 2.511 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003127 | 2.505 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.003644 | 2.438 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.003700 | 2.432 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.004088 | 2.388 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.004144 | 2.383 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.004821 | 2.317 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.004859 | 2.313 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.004859 | 2.313 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.005795 | 2.237 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.005795 | 2.237 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.005795 | 2.237 |
| R-HSA-5617833 | Cilium Assembly | 0.005907 | 2.229 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.005795 | 2.237 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.007269 | 2.138 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.006851 | 2.164 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.006911 | 2.160 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.008219 | 2.085 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.007674 | 2.115 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.008786 | 2.056 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.008786 | 2.056 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.008054 | 2.094 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.007538 | 2.123 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.008609 | 2.065 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.008609 | 2.065 |
| R-HSA-5357801 | Programmed Cell Death | 0.008665 | 2.062 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.009441 | 2.025 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.010494 | 1.979 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.010494 | 1.979 |
| R-HSA-163560 | Triglyceride catabolism | 0.009987 | 2.001 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.010622 | 1.974 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.011125 | 1.954 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.011280 | 1.948 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.011960 | 1.922 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.014142 | 1.849 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.015048 | 1.823 |
| R-HSA-69481 | G2/M Checkpoints | 0.015673 | 1.805 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.015714 | 1.804 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.016397 | 1.785 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.017298 | 1.762 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.018049 | 1.744 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.019768 | 1.704 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.019768 | 1.704 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.019768 | 1.704 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.018248 | 1.739 |
| R-HSA-9675135 | Diseases of DNA repair | 0.018248 | 1.739 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.019768 | 1.704 |
| R-HSA-199991 | Membrane Trafficking | 0.019943 | 1.700 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 0.020164 | 1.695 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 0.020164 | 1.695 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.023403 | 1.631 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.023098 | 1.636 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.023403 | 1.631 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.023941 | 1.621 |
| R-HSA-2028269 | Signaling by Hippo | 0.021554 | 1.666 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.021050 | 1.677 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.021370 | 1.670 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.027289 | 1.564 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.024995 | 1.602 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.028244 | 1.549 |
| R-HSA-445144 | Signal transduction by L1 | 0.027289 | 1.564 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.024529 | 1.610 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.025315 | 1.597 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.026691 | 1.574 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.027650 | 1.558 |
| R-HSA-75893 | TNF signaling | 0.028244 | 1.549 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.028244 | 1.549 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.027289 | 1.564 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.027289 | 1.564 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.028273 | 1.549 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 0.030094 | 1.522 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.031414 | 1.503 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.031414 | 1.503 |
| R-HSA-8979227 | Triglyceride metabolism | 0.031707 | 1.499 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.033563 | 1.474 |
| R-HSA-9612973 | Autophagy | 0.033580 | 1.474 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 0.039924 | 1.399 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.036653 | 1.436 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.036653 | 1.436 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.040608 | 1.391 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.040783 | 1.390 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.035382 | 1.451 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.040341 | 1.394 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.038028 | 1.420 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.040341 | 1.394 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.040341 | 1.394 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.040341 | 1.394 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.036450 | 1.438 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.040341 | 1.394 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.041094 | 1.386 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.041972 | 1.377 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.042705 | 1.370 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.043359 | 1.363 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.045120 | 1.346 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.045120 | 1.346 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.046201 | 1.335 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.049655 | 1.304 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.050098 | 1.300 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.050098 | 1.300 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.047656 | 1.322 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.047656 | 1.322 |
| R-HSA-5693538 | Homology Directed Repair | 0.046929 | 1.329 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.049655 | 1.304 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.052154 | 1.283 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.055262 | 1.258 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.053698 | 1.270 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.049655 | 1.304 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.048664 | 1.313 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.052657 | 1.279 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.049133 | 1.309 |
| R-HSA-73886 | Chromosome Maintenance | 0.050185 | 1.299 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.052657 | 1.279 |
| R-HSA-1538133 | G0 and Early G1 | 0.057912 | 1.237 |
| R-HSA-4839726 | Chromatin organization | 0.058388 | 1.234 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.059288 | 1.227 |
| R-HSA-191650 | Regulation of gap junction activity | 0.059288 | 1.227 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.059288 | 1.227 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.059288 | 1.227 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.078263 | 1.106 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.078263 | 1.106 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.077531 | 1.111 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.078263 | 1.106 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.068824 | 1.162 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.060605 | 1.217 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.063413 | 1.198 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.078263 | 1.106 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.078263 | 1.106 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.061741 | 1.209 |
| R-HSA-9663891 | Selective autophagy | 0.077531 | 1.111 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.068934 | 1.162 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.060605 | 1.217 |
| R-HSA-1632852 | Macroautophagy | 0.079123 | 1.102 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 0.068824 | 1.162 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.068824 | 1.162 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.076736 | 1.115 |
| R-HSA-75158 | TRAIL signaling | 0.078263 | 1.106 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.070310 | 1.153 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.064781 | 1.189 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.061904 | 1.208 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.060605 | 1.217 |
| R-HSA-162582 | Signal Transduction | 0.071744 | 1.144 |
| R-HSA-5673000 | RAF activation | 0.066117 | 1.180 |
| R-HSA-74160 | Gene expression (Transcription) | 0.073610 | 1.133 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.067995 | 1.168 |
| R-HSA-212436 | Generic Transcription Pathway | 0.079208 | 1.101 |
| R-HSA-9909396 | Circadian clock | 0.065689 | 1.183 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.081971 | 1.086 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.083151 | 1.080 |
| R-HSA-9646399 | Aggrephagy | 0.083579 | 1.078 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.083579 | 1.078 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.086631 | 1.062 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.087608 | 1.057 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.087608 | 1.057 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.106016 | 0.975 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.106016 | 0.975 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.106016 | 0.975 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.106016 | 0.975 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.115081 | 0.939 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.115081 | 0.939 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.167584 | 0.776 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.176028 | 0.754 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.176028 | 0.754 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.184387 | 0.734 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.184387 | 0.734 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.216989 | 0.664 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.232801 | 0.633 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.102258 | 0.990 |
| R-HSA-774815 | Nucleosome assembly | 0.102258 | 0.990 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.105474 | 0.977 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.240588 | 0.619 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.108718 | 0.964 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.248296 | 0.605 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.125317 | 0.902 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.128707 | 0.890 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.135549 | 0.868 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.139001 | 0.857 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.145960 | 0.836 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.232801 | 0.633 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.232801 | 0.633 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.200853 | 0.697 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.200853 | 0.697 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.102258 | 0.990 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.102258 | 0.990 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.173560 | 0.761 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.224935 | 0.648 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.208962 | 0.680 |
| R-HSA-177929 | Signaling by EGFR | 0.139001 | 0.857 |
| R-HSA-180292 | GAB1 signalosome | 0.208962 | 0.680 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.132937 | 0.876 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.248296 | 0.605 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.263479 | 0.579 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.224935 | 0.648 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.207432 | 0.683 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.096858 | 1.014 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.150436 | 0.823 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.200853 | 0.697 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.232801 | 0.633 |
| R-HSA-72187 | mRNA 3'-end processing | 0.125317 | 0.902 |
| R-HSA-72172 | mRNA Splicing | 0.195840 | 0.708 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.096858 | 1.014 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.115081 | 0.939 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.124054 | 0.906 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.159053 | 0.798 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.159053 | 0.798 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.159053 | 0.798 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.184387 | 0.734 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.192662 | 0.715 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.192662 | 0.715 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.208962 | 0.680 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.132117 | 0.879 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.156530 | 0.805 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.185354 | 0.732 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.208962 | 0.680 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.200853 | 0.697 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.200853 | 0.697 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.096858 | 1.014 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.106016 | 0.975 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.167584 | 0.776 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.248296 | 0.605 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.098461 | 1.007 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.189011 | 0.724 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 0.106016 | 0.975 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.192662 | 0.715 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.208962 | 0.680 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.216989 | 0.664 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.232801 | 0.633 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.263479 | 0.579 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.163656 | 0.786 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.106016 | 0.975 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.124054 | 0.906 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.160085 | 0.796 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.200039 | 0.699 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.167584 | 0.776 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.089680 | 1.047 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.105474 | 0.977 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.135549 | 0.868 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.181708 | 0.741 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.096858 | 1.014 |
| R-HSA-425381 | Bicarbonate transporters | 0.132937 | 0.876 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.150436 | 0.823 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.150436 | 0.823 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.200853 | 0.697 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.248296 | 0.605 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.124054 | 0.906 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.142471 | 0.846 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.096858 | 1.014 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.192411 | 0.716 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.223810 | 0.650 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.248296 | 0.605 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.115081 | 0.939 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.115081 | 0.939 |
| R-HSA-5682910 | LGI-ADAM interactions | 0.132937 | 0.876 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.159053 | 0.798 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.167584 | 0.776 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.176028 | 0.754 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.176028 | 0.754 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.248296 | 0.605 |
| R-HSA-8848021 | Signaling by PTK6 | 0.163656 | 0.786 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.163656 | 0.786 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.184387 | 0.734 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.247141 | 0.607 |
| R-HSA-73887 | Death Receptor Signaling | 0.100033 | 1.000 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.167584 | 0.776 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.208962 | 0.680 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.125317 | 0.902 |
| R-HSA-73894 | DNA Repair | 0.192854 | 0.715 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.232801 | 0.633 |
| R-HSA-9659379 | Sensory processing of sound | 0.222302 | 0.653 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.167584 | 0.776 |
| R-HSA-5218859 | Regulated Necrosis | 0.181708 | 0.741 |
| R-HSA-69242 | S Phase | 0.090780 | 1.042 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.240588 | 0.619 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.145432 | 0.837 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.184387 | 0.734 |
| R-HSA-397014 | Muscle contraction | 0.212572 | 0.672 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.150436 | 0.823 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.089680 | 1.047 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.111989 | 0.951 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.259772 | 0.585 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.255926 | 0.592 |
| R-HSA-5688426 | Deubiquitination | 0.150817 | 0.822 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.203732 | 0.691 |
| R-HSA-210991 | Basigin interactions | 0.232801 | 0.633 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.240588 | 0.619 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.125317 | 0.902 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.203732 | 0.691 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.133812 | 0.874 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.152580 | 0.817 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.119138 | 0.924 |
| R-HSA-3928664 | Ephrin signaling | 0.208962 | 0.680 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.244752 | 0.611 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.224935 | 0.648 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.240588 | 0.619 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.255926 | 0.592 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.196354 | 0.707 |
| R-HSA-69206 | G1/S Transition | 0.172161 | 0.764 |
| R-HSA-157118 | Signaling by NOTCH | 0.127841 | 0.893 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.248296 | 0.605 |
| R-HSA-180786 | Extension of Telomeres | 0.149467 | 0.825 |
| R-HSA-379724 | tRNA Aminoacylation | 0.152990 | 0.815 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.165886 | 0.780 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.181708 | 0.741 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.234497 | 0.630 |
| R-HSA-449836 | Other interleukin signaling | 0.216989 | 0.664 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.219422 | 0.659 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.255926 | 0.592 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.245275 | 0.610 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.200853 | 0.697 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.099069 | 1.004 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.263479 | 0.579 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.263479 | 0.579 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.250693 | 0.601 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.203732 | 0.691 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.252259 | 0.598 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.247982 | 0.606 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.125317 | 0.902 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.248296 | 0.605 |
| R-HSA-373755 | Semaphorin interactions | 0.163656 | 0.786 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.109705 | 0.960 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.098956 | 1.005 |
| R-HSA-449147 | Signaling by Interleukins | 0.214350 | 0.669 |
| R-HSA-877300 | Interferon gamma signaling | 0.269791 | 0.569 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.270956 | 0.567 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.278358 | 0.555 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.278358 | 0.555 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.278358 | 0.555 |
| R-HSA-525793 | Myogenesis | 0.278358 | 0.555 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.278358 | 0.555 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.278358 | 0.555 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.278358 | 0.555 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.282316 | 0.549 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.285685 | 0.544 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.285685 | 0.544 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.285685 | 0.544 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.285685 | 0.544 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.285685 | 0.544 |
| R-HSA-264876 | Insulin processing | 0.285685 | 0.544 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.285685 | 0.544 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.286070 | 0.544 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.292938 | 0.533 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.292938 | 0.533 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.292938 | 0.533 |
| R-HSA-77387 | Insulin receptor recycling | 0.292938 | 0.533 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.292938 | 0.533 |
| R-HSA-5620971 | Pyroptosis | 0.292938 | 0.533 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.297319 | 0.527 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.300118 | 0.523 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.300118 | 0.523 |
| R-HSA-180024 | DARPP-32 events | 0.300118 | 0.523 |
| R-HSA-157579 | Telomere Maintenance | 0.301063 | 0.521 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.304804 | 0.516 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.304804 | 0.516 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.304804 | 0.516 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.304804 | 0.516 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.307225 | 0.513 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.307225 | 0.513 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.307225 | 0.513 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.307225 | 0.513 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.307225 | 0.513 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.307225 | 0.513 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.307225 | 0.513 |
| R-HSA-3214847 | HATs acetylate histones | 0.308542 | 0.511 |
| R-HSA-182971 | EGFR downregulation | 0.314261 | 0.503 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.314261 | 0.503 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.314261 | 0.503 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.314261 | 0.503 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.314261 | 0.503 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.314261 | 0.503 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.314261 | 0.503 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.316005 | 0.500 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.316005 | 0.500 |
| R-HSA-1483255 | PI Metabolism | 0.319730 | 0.495 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.321225 | 0.493 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.321225 | 0.493 |
| R-HSA-111885 | Opioid Signalling | 0.327165 | 0.485 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.328120 | 0.484 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.328120 | 0.484 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.328120 | 0.484 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.328120 | 0.484 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.328120 | 0.484 |
| R-HSA-354192 | Integrin signaling | 0.328120 | 0.484 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.334579 | 0.476 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.334944 | 0.475 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.334944 | 0.475 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.338277 | 0.471 |
| R-HSA-5205647 | Mitophagy | 0.341700 | 0.466 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.341700 | 0.466 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.341700 | 0.466 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.341700 | 0.466 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.341700 | 0.466 |
| R-HSA-69239 | Synthesis of DNA | 0.341969 | 0.466 |
| R-HSA-211000 | Gene Silencing by RNA | 0.341969 | 0.466 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.345655 | 0.461 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.348387 | 0.458 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.348387 | 0.458 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.348387 | 0.458 |
| R-HSA-169911 | Regulation of Apoptosis | 0.348387 | 0.458 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.348387 | 0.458 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.348387 | 0.458 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.349334 | 0.457 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.349334 | 0.457 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.355007 | 0.450 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.355007 | 0.450 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.355007 | 0.450 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.355007 | 0.450 |
| R-HSA-111933 | Calmodulin induced events | 0.355007 | 0.450 |
| R-HSA-111997 | CaM pathway | 0.355007 | 0.450 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.355007 | 0.450 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.355007 | 0.450 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.355007 | 0.450 |
| R-HSA-422475 | Axon guidance | 0.355215 | 0.450 |
| R-HSA-4641258 | Degradation of DVL | 0.361561 | 0.442 |
| R-HSA-4641257 | Degradation of AXIN | 0.361561 | 0.442 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.361561 | 0.442 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.361561 | 0.442 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.363980 | 0.439 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.368048 | 0.434 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.368048 | 0.434 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.368048 | 0.434 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.371257 | 0.430 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.374469 | 0.427 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.374469 | 0.427 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.374469 | 0.427 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.374469 | 0.427 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.374469 | 0.427 |
| R-HSA-69541 | Stabilization of p53 | 0.374469 | 0.427 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.374883 | 0.426 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.380826 | 0.419 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.380826 | 0.419 |
| R-HSA-167169 | HIV Transcription Elongation | 0.380826 | 0.419 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.380826 | 0.419 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.380826 | 0.419 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.380826 | 0.419 |
| R-HSA-373760 | L1CAM interactions | 0.382110 | 0.418 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.385710 | 0.414 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.385975 | 0.413 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.387118 | 0.412 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.387118 | 0.412 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.387118 | 0.412 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.387118 | 0.412 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.387118 | 0.412 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.387118 | 0.412 |
| R-HSA-9824446 | Viral Infection Pathways | 0.387450 | 0.412 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.392883 | 0.406 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.392883 | 0.406 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.392883 | 0.406 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.393347 | 0.405 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.393347 | 0.405 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.393347 | 0.405 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.393347 | 0.405 |
| R-HSA-68875 | Mitotic Prophase | 0.396456 | 0.402 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.399513 | 0.398 |
| R-HSA-165159 | MTOR signalling | 0.399513 | 0.398 |
| R-HSA-111996 | Ca-dependent events | 0.399513 | 0.398 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.399513 | 0.398 |
| R-HSA-1483257 | Phospholipid metabolism | 0.399735 | 0.398 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.402024 | 0.396 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.403572 | 0.394 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.403572 | 0.394 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.405617 | 0.392 |
| R-HSA-8854214 | TBC/RABGAPs | 0.405617 | 0.392 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.407116 | 0.390 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.407116 | 0.390 |
| R-HSA-9907900 | Proteasome assembly | 0.411658 | 0.385 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.411658 | 0.385 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.411658 | 0.385 |
| R-HSA-9675108 | Nervous system development | 0.416785 | 0.380 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.417639 | 0.379 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.417639 | 0.379 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.417639 | 0.379 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.417639 | 0.379 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.417639 | 0.379 |
| R-HSA-9824272 | Somitogenesis | 0.417639 | 0.379 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.417639 | 0.379 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.423560 | 0.373 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.423560 | 0.373 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.423926 | 0.373 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.428159 | 0.368 |
| R-HSA-437239 | Recycling pathway of L1 | 0.429421 | 0.367 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.429421 | 0.367 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.429421 | 0.367 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.435088 | 0.361 |
| R-HSA-5620924 | Intraflagellar transport | 0.435222 | 0.361 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.435222 | 0.361 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.439468 | 0.357 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.440965 | 0.356 |
| R-HSA-9766229 | Degradation of CDH1 | 0.440965 | 0.356 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.440965 | 0.356 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.440965 | 0.356 |
| R-HSA-8951664 | Neddylation | 0.445336 | 0.351 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.446650 | 0.350 |
| R-HSA-597592 | Post-translational protein modification | 0.447055 | 0.350 |
| R-HSA-912446 | Meiotic recombination | 0.452277 | 0.345 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.452277 | 0.345 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.452277 | 0.345 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.452277 | 0.345 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.452277 | 0.345 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.457847 | 0.339 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.457847 | 0.339 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.457847 | 0.339 |
| R-HSA-162906 | HIV Infection | 0.461189 | 0.336 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.463361 | 0.334 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.463361 | 0.334 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.468127 | 0.330 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.471467 | 0.327 |
| R-HSA-6807070 | PTEN Regulation | 0.472364 | 0.326 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.474223 | 0.324 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.484866 | 0.314 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.484866 | 0.314 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.485553 | 0.314 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.495295 | 0.305 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.495295 | 0.305 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.500430 | 0.301 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.500430 | 0.301 |
| R-HSA-351202 | Metabolism of polyamines | 0.500430 | 0.301 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.500430 | 0.301 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.500430 | 0.301 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.500430 | 0.301 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.500430 | 0.301 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.500430 | 0.301 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.500430 | 0.301 |
| R-HSA-166520 | Signaling by NTRKs | 0.504950 | 0.297 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.505514 | 0.296 |
| R-HSA-112043 | PLC beta mediated events | 0.505514 | 0.296 |
| R-HSA-450294 | MAP kinase activation | 0.505514 | 0.296 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.505514 | 0.296 |
| R-HSA-8953854 | Metabolism of RNA | 0.509296 | 0.293 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.510546 | 0.292 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.511311 | 0.291 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.515447 | 0.288 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.515527 | 0.288 |
| R-HSA-6799198 | Complex I biogenesis | 0.515527 | 0.288 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.517619 | 0.286 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.519711 | 0.284 |
| R-HSA-9609646 | HCMV Infection | 0.520027 | 0.284 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.520458 | 0.284 |
| R-HSA-9609507 | Protein localization | 0.520752 | 0.283 |
| R-HSA-69306 | DNA Replication | 0.520752 | 0.283 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.525339 | 0.280 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.525339 | 0.280 |
| R-HSA-162587 | HIV Life Cycle | 0.533151 | 0.273 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.534953 | 0.272 |
| R-HSA-112040 | G-protein mediated events | 0.534953 | 0.272 |
| R-HSA-167172 | Transcription of the HIV genome | 0.539687 | 0.268 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.549013 | 0.260 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.549013 | 0.260 |
| R-HSA-448424 | Interleukin-17 signaling | 0.549013 | 0.260 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.549013 | 0.260 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.553605 | 0.257 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.553605 | 0.257 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.558150 | 0.253 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.562650 | 0.250 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.563589 | 0.249 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.567104 | 0.246 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.571513 | 0.243 |
| R-HSA-8852135 | Protein ubiquitination | 0.571513 | 0.243 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.574807 | 0.240 |
| R-HSA-5689603 | UCH proteinases | 0.575877 | 0.240 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.575877 | 0.240 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.577678 | 0.238 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.584473 | 0.233 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.584473 | 0.233 |
| R-HSA-5619084 | ABC transporter disorders | 0.584473 | 0.233 |
| R-HSA-4086400 | PCP/CE pathway | 0.584473 | 0.233 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.589019 | 0.230 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.589019 | 0.230 |
| R-HSA-6806834 | Signaling by MET | 0.592897 | 0.227 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.597044 | 0.224 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.601150 | 0.221 |
| R-HSA-2559583 | Cellular Senescence | 0.602878 | 0.220 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.605214 | 0.218 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.609237 | 0.215 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.609237 | 0.215 |
| R-HSA-1500620 | Meiosis | 0.613220 | 0.212 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.613220 | 0.212 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.617162 | 0.210 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.617162 | 0.210 |
| R-HSA-1643685 | Disease | 0.617981 | 0.209 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.624319 | 0.205 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.624926 | 0.204 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.632534 | 0.199 |
| R-HSA-1266738 | Developmental Biology | 0.633557 | 0.198 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.636280 | 0.196 |
| R-HSA-202424 | Downstream TCR signaling | 0.636280 | 0.196 |
| R-HSA-9609690 | HCMV Early Events | 0.644860 | 0.191 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.647293 | 0.189 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.654450 | 0.184 |
| R-HSA-1474290 | Collagen formation | 0.654450 | 0.184 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.661462 | 0.179 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.662102 | 0.179 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.662102 | 0.179 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.664915 | 0.177 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.668333 | 0.175 |
| R-HSA-422356 | Regulation of insulin secretion | 0.671717 | 0.173 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.675066 | 0.171 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.678381 | 0.169 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.678381 | 0.169 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.680886 | 0.167 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.684910 | 0.164 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.684910 | 0.164 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.684910 | 0.164 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.685568 | 0.164 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.691308 | 0.160 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.691308 | 0.160 |
| R-HSA-9833110 | RSV-host interactions | 0.694459 | 0.158 |
| R-HSA-9679506 | SARS-CoV Infections | 0.701394 | 0.154 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.703719 | 0.153 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.703719 | 0.153 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.706744 | 0.151 |
| R-HSA-202403 | TCR signaling | 0.712701 | 0.147 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.718538 | 0.144 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.724257 | 0.140 |
| R-HSA-72312 | rRNA processing | 0.728507 | 0.138 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.729860 | 0.137 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.732620 | 0.135 |
| R-HSA-112316 | Neuronal System | 0.736498 | 0.133 |
| R-HSA-2262752 | Cellular responses to stress | 0.737274 | 0.132 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.738054 | 0.132 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.738054 | 0.132 |
| R-HSA-8939211 | ESR-mediated signaling | 0.738439 | 0.132 |
| R-HSA-3371556 | Cellular response to heat stress | 0.748596 | 0.126 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.748596 | 0.126 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.756225 | 0.121 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.756263 | 0.121 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.757382 | 0.121 |
| R-HSA-194138 | Signaling by VEGF | 0.761182 | 0.119 |
| R-HSA-114608 | Platelet degranulation | 0.766040 | 0.116 |
| R-HSA-5663205 | Infectious disease | 0.766920 | 0.115 |
| R-HSA-1474165 | Reproduction | 0.775462 | 0.110 |
| R-HSA-913531 | Interferon Signaling | 0.781904 | 0.107 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.782280 | 0.107 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.791052 | 0.102 |
| R-HSA-163685 | Integration of energy metabolism | 0.791052 | 0.102 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.795305 | 0.099 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.795305 | 0.099 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.802734 | 0.095 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.807555 | 0.093 |
| R-HSA-446728 | Cell junction organization | 0.808777 | 0.092 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.809525 | 0.092 |
| R-HSA-418594 | G alpha (i) signalling events | 0.813769 | 0.089 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.814656 | 0.089 |
| R-HSA-9758941 | Gastrulation | 0.819077 | 0.087 |
| R-HSA-392499 | Metabolism of proteins | 0.822175 | 0.085 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.824578 | 0.084 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.828152 | 0.082 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.828152 | 0.082 |
| R-HSA-9610379 | HCMV Late Events | 0.833379 | 0.079 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.835086 | 0.078 |
| R-HSA-72766 | Translation | 0.839454 | 0.076 |
| R-HSA-5619102 | SLC transporter disorders | 0.849686 | 0.071 |
| R-HSA-1500931 | Cell-Cell communication | 0.858469 | 0.066 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.858698 | 0.066 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.860147 | 0.065 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.860147 | 0.065 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.866232 | 0.062 |
| R-HSA-611105 | Respiratory electron transport | 0.867173 | 0.062 |
| R-HSA-6798695 | Neutrophil degranulation | 0.867703 | 0.062 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.873848 | 0.059 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.889684 | 0.051 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.894146 | 0.049 |
| R-HSA-428157 | Sphingolipid metabolism | 0.895234 | 0.048 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.897375 | 0.047 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.903596 | 0.044 |
| R-HSA-418990 | Adherens junctions interactions | 0.913012 | 0.040 |
| R-HSA-109582 | Hemostasis | 0.916655 | 0.038 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.919091 | 0.037 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.923717 | 0.034 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.928532 | 0.032 |
| R-HSA-168249 | Innate Immune System | 0.938099 | 0.028 |
| R-HSA-421270 | Cell-cell junction organization | 0.938176 | 0.028 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.941297 | 0.026 |
| R-HSA-416476 | G alpha (q) signalling events | 0.945969 | 0.024 |
| R-HSA-195721 | Signaling by WNT | 0.962034 | 0.017 |
| R-HSA-388396 | GPCR downstream signalling | 0.963672 | 0.016 |
| R-HSA-1474244 | Extracellular matrix organization | 0.973063 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 0.974657 | 0.011 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.975728 | 0.011 |
| R-HSA-372790 | Signaling by GPCR | 0.980367 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.986611 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 0.987941 | 0.005 |
| R-HSA-1280218 | Adaptive Immune System | 0.995577 | 0.002 |
| R-HSA-168256 | Immune System | 0.997809 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998121 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998694 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999976 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.868 | 0.557 | 1 | 0.929 |
CDK8 |
0.864 | 0.582 | 1 | 0.933 |
CDK19 |
0.864 | 0.586 | 1 | 0.924 |
CDK5 |
0.863 | 0.603 | 1 | 0.940 |
CLK3 |
0.863 | 0.400 | 1 | 0.865 |
CDK1 |
0.862 | 0.605 | 1 | 0.932 |
JNK2 |
0.860 | 0.654 | 1 | 0.930 |
CDK3 |
0.860 | 0.580 | 1 | 0.910 |
NLK |
0.860 | 0.574 | 1 | 0.900 |
CDK18 |
0.859 | 0.606 | 1 | 0.914 |
JNK3 |
0.857 | 0.639 | 1 | 0.937 |
P38G |
0.856 | 0.625 | 1 | 0.902 |
CDK13 |
0.855 | 0.578 | 1 | 0.934 |
CDK17 |
0.854 | 0.602 | 1 | 0.901 |
ERK5 |
0.854 | 0.384 | 1 | 0.820 |
ERK1 |
0.853 | 0.593 | 1 | 0.913 |
COT |
0.852 | 0.062 | 2 | 0.890 |
CDK7 |
0.852 | 0.551 | 1 | 0.943 |
P38B |
0.851 | 0.601 | 1 | 0.913 |
P38D |
0.850 | 0.633 | 1 | 0.899 |
CDK16 |
0.849 | 0.600 | 1 | 0.905 |
P38A |
0.847 | 0.576 | 1 | 0.923 |
CDK12 |
0.847 | 0.565 | 1 | 0.927 |
DYRK2 |
0.846 | 0.502 | 1 | 0.914 |
CDK2 |
0.845 | 0.479 | 1 | 0.926 |
HIPK2 |
0.845 | 0.518 | 1 | 0.899 |
MTOR |
0.845 | 0.137 | 1 | 0.763 |
HIPK4 |
0.845 | 0.316 | 1 | 0.840 |
ERK2 |
0.844 | 0.583 | 1 | 0.918 |
CDK9 |
0.843 | 0.548 | 1 | 0.931 |
SRPK1 |
0.843 | 0.231 | -3 | 0.689 |
CDK14 |
0.841 | 0.570 | 1 | 0.927 |
CDC7 |
0.840 | -0.025 | 1 | 0.706 |
MOS |
0.839 | 0.011 | 1 | 0.739 |
DSTYK |
0.839 | -0.007 | 2 | 0.901 |
PRPK |
0.838 | -0.063 | -1 | 0.846 |
HIPK1 |
0.838 | 0.467 | 1 | 0.909 |
CDK10 |
0.837 | 0.543 | 1 | 0.923 |
NEK6 |
0.837 | 0.014 | -2 | 0.808 |
CDKL1 |
0.836 | 0.086 | -3 | 0.755 |
CDK6 |
0.836 | 0.572 | 1 | 0.917 |
GCN2 |
0.836 | -0.115 | 2 | 0.836 |
JNK1 |
0.835 | 0.567 | 1 | 0.927 |
IKKB |
0.835 | -0.090 | -2 | 0.746 |
TBK1 |
0.835 | -0.084 | 1 | 0.630 |
ICK |
0.835 | 0.217 | -3 | 0.799 |
PRKD1 |
0.834 | 0.054 | -3 | 0.784 |
SRPK2 |
0.834 | 0.180 | -3 | 0.608 |
CLK1 |
0.834 | 0.284 | -3 | 0.679 |
CDKL5 |
0.834 | 0.100 | -3 | 0.745 |
CDK4 |
0.833 | 0.576 | 1 | 0.920 |
BMPR2 |
0.833 | -0.075 | -2 | 0.839 |
PIM3 |
0.833 | -0.032 | -3 | 0.797 |
CLK2 |
0.833 | 0.296 | -3 | 0.685 |
ULK2 |
0.832 | -0.122 | 2 | 0.843 |
DYRK1B |
0.832 | 0.482 | 1 | 0.934 |
TGFBR2 |
0.832 | -0.018 | -2 | 0.779 |
RAF1 |
0.831 | -0.162 | 1 | 0.697 |
IKKE |
0.831 | -0.086 | 1 | 0.629 |
DYRK4 |
0.831 | 0.501 | 1 | 0.921 |
CLK4 |
0.831 | 0.242 | -3 | 0.703 |
IKKA |
0.830 | 0.001 | -2 | 0.741 |
HIPK3 |
0.829 | 0.437 | 1 | 0.904 |
DYRK1A |
0.829 | 0.382 | 1 | 0.924 |
SRPK3 |
0.829 | 0.163 | -3 | 0.661 |
NDR2 |
0.829 | -0.035 | -3 | 0.815 |
PDHK4 |
0.829 | -0.205 | 1 | 0.734 |
ATR |
0.828 | -0.057 | 1 | 0.681 |
NEK7 |
0.828 | -0.106 | -3 | 0.840 |
PRKD2 |
0.828 | 0.032 | -3 | 0.722 |
MST4 |
0.828 | 0.008 | 2 | 0.882 |
PKN3 |
0.827 | -0.039 | -3 | 0.791 |
CHAK2 |
0.827 | -0.022 | -1 | 0.805 |
CAMK1B |
0.827 | -0.070 | -3 | 0.820 |
GRK1 |
0.827 | 0.016 | -2 | 0.748 |
NUAK2 |
0.827 | -0.005 | -3 | 0.792 |
NIK |
0.826 | -0.055 | -3 | 0.849 |
MLK1 |
0.825 | -0.086 | 2 | 0.863 |
ULK1 |
0.825 | -0.126 | -3 | 0.831 |
PDHK1 |
0.824 | -0.191 | 1 | 0.703 |
RSK2 |
0.824 | -0.007 | -3 | 0.720 |
PIM1 |
0.824 | 0.012 | -3 | 0.727 |
PRP4 |
0.824 | 0.325 | -3 | 0.768 |
PKCD |
0.823 | 0.005 | 2 | 0.845 |
MAPKAPK3 |
0.823 | -0.023 | -3 | 0.721 |
BMPR1B |
0.823 | 0.049 | 1 | 0.661 |
CAMK2G |
0.823 | -0.123 | 2 | 0.778 |
NEK9 |
0.823 | -0.076 | 2 | 0.895 |
NDR1 |
0.822 | -0.068 | -3 | 0.795 |
MAPKAPK2 |
0.821 | 0.001 | -3 | 0.677 |
P90RSK |
0.821 | -0.020 | -3 | 0.724 |
ALK4 |
0.821 | 0.011 | -2 | 0.805 |
GRK5 |
0.820 | -0.161 | -3 | 0.849 |
CAMLCK |
0.820 | -0.065 | -2 | 0.776 |
GRK7 |
0.820 | 0.041 | 1 | 0.668 |
GRK6 |
0.819 | -0.045 | 1 | 0.691 |
AMPKA1 |
0.819 | -0.061 | -3 | 0.810 |
MLK2 |
0.819 | -0.087 | 2 | 0.881 |
TGFBR1 |
0.819 | 0.017 | -2 | 0.783 |
WNK1 |
0.819 | -0.097 | -2 | 0.780 |
MARK4 |
0.819 | -0.076 | 4 | 0.767 |
MLK3 |
0.819 | -0.008 | 2 | 0.805 |
DYRK3 |
0.819 | 0.336 | 1 | 0.889 |
PKN2 |
0.818 | -0.060 | -3 | 0.782 |
DAPK2 |
0.818 | -0.095 | -3 | 0.830 |
BCKDK |
0.818 | -0.145 | -1 | 0.802 |
LATS1 |
0.818 | 0.029 | -3 | 0.844 |
PKR |
0.817 | 0.020 | 1 | 0.668 |
LATS2 |
0.817 | -0.061 | -5 | 0.731 |
DLK |
0.817 | -0.160 | 1 | 0.684 |
HUNK |
0.817 | -0.175 | 2 | 0.818 |
P70S6KB |
0.816 | -0.044 | -3 | 0.740 |
RSK3 |
0.816 | -0.047 | -3 | 0.711 |
AMPKA2 |
0.815 | -0.045 | -3 | 0.771 |
ACVR2A |
0.815 | -0.004 | -2 | 0.787 |
TSSK2 |
0.814 | -0.060 | -5 | 0.820 |
ERK7 |
0.814 | 0.224 | 2 | 0.592 |
SKMLCK |
0.814 | -0.112 | -2 | 0.764 |
MAK |
0.814 | 0.342 | -2 | 0.675 |
RIPK3 |
0.814 | -0.179 | 3 | 0.667 |
AURC |
0.814 | -0.016 | -2 | 0.571 |
TSSK1 |
0.814 | -0.041 | -3 | 0.835 |
YSK4 |
0.813 | -0.099 | 1 | 0.649 |
ACVR2B |
0.813 | -0.006 | -2 | 0.799 |
PLK1 |
0.813 | -0.083 | -2 | 0.784 |
MASTL |
0.813 | -0.253 | -2 | 0.759 |
CHK1 |
0.812 | 0.008 | -3 | 0.805 |
NIM1 |
0.812 | -0.072 | 3 | 0.721 |
PRKD3 |
0.812 | -0.010 | -3 | 0.675 |
CAMK2D |
0.812 | -0.118 | -3 | 0.801 |
ANKRD3 |
0.812 | -0.188 | 1 | 0.690 |
IRE1 |
0.812 | -0.097 | 1 | 0.613 |
IRE2 |
0.812 | -0.060 | 2 | 0.834 |
ATM |
0.811 | -0.072 | 1 | 0.623 |
ALK2 |
0.811 | -0.002 | -2 | 0.792 |
PKCA |
0.811 | -0.003 | 2 | 0.803 |
MLK4 |
0.811 | -0.052 | 2 | 0.782 |
PINK1 |
0.811 | 0.088 | 1 | 0.767 |
WNK3 |
0.810 | -0.261 | 1 | 0.660 |
PKCB |
0.810 | -0.023 | 2 | 0.811 |
MEK1 |
0.810 | -0.129 | 2 | 0.852 |
GRK4 |
0.810 | -0.160 | -2 | 0.771 |
VRK2 |
0.809 | -0.049 | 1 | 0.741 |
PERK |
0.809 | -0.059 | -2 | 0.823 |
MNK2 |
0.809 | -0.046 | -2 | 0.698 |
TTBK2 |
0.808 | -0.187 | 2 | 0.749 |
PAK6 |
0.808 | 0.000 | -2 | 0.652 |
NUAK1 |
0.808 | -0.074 | -3 | 0.739 |
CAMK2B |
0.808 | -0.060 | 2 | 0.736 |
RSK4 |
0.808 | -0.016 | -3 | 0.695 |
NEK2 |
0.808 | -0.103 | 2 | 0.877 |
PKACG |
0.807 | -0.089 | -2 | 0.648 |
MOK |
0.807 | 0.317 | 1 | 0.844 |
PKCG |
0.807 | -0.047 | 2 | 0.797 |
CHAK1 |
0.807 | -0.111 | 2 | 0.846 |
QSK |
0.807 | -0.061 | 4 | 0.747 |
HRI |
0.807 | -0.093 | -2 | 0.822 |
MPSK1 |
0.807 | 0.086 | 1 | 0.653 |
PHKG1 |
0.806 | -0.087 | -3 | 0.777 |
MELK |
0.806 | -0.092 | -3 | 0.748 |
SMG1 |
0.806 | -0.047 | 1 | 0.633 |
BMPR1A |
0.806 | 0.023 | 1 | 0.643 |
CAMK4 |
0.806 | -0.153 | -3 | 0.772 |
DNAPK |
0.805 | -0.036 | 1 | 0.604 |
FAM20C |
0.805 | -0.013 | 2 | 0.566 |
PAK1 |
0.805 | -0.095 | -2 | 0.701 |
GSK3A |
0.805 | 0.145 | 4 | 0.453 |
QIK |
0.804 | -0.125 | -3 | 0.788 |
MEKK1 |
0.804 | -0.088 | 1 | 0.665 |
MNK1 |
0.804 | -0.041 | -2 | 0.713 |
TLK2 |
0.804 | -0.107 | 1 | 0.654 |
TAO3 |
0.803 | 0.005 | 1 | 0.685 |
MEKK2 |
0.803 | -0.057 | 2 | 0.867 |
CAMK2A |
0.803 | -0.066 | 2 | 0.744 |
PKCZ |
0.803 | -0.076 | 2 | 0.853 |
AKT2 |
0.803 | -0.012 | -3 | 0.617 |
PKCH |
0.803 | -0.066 | 2 | 0.801 |
PAK3 |
0.803 | -0.127 | -2 | 0.708 |
SIK |
0.803 | -0.073 | -3 | 0.702 |
AURB |
0.803 | -0.052 | -2 | 0.570 |
PIM2 |
0.802 | -0.015 | -3 | 0.682 |
BRSK1 |
0.802 | -0.083 | -3 | 0.734 |
MSK2 |
0.802 | -0.102 | -3 | 0.681 |
PLK3 |
0.802 | -0.102 | 2 | 0.743 |
PKACB |
0.802 | -0.028 | -2 | 0.586 |
RIPK1 |
0.801 | -0.266 | 1 | 0.631 |
BRSK2 |
0.801 | -0.108 | -3 | 0.764 |
NEK5 |
0.800 | -0.080 | 1 | 0.658 |
MST3 |
0.800 | -0.014 | 2 | 0.879 |
BRAF |
0.800 | -0.117 | -4 | 0.777 |
GRK2 |
0.800 | -0.082 | -2 | 0.675 |
MEK5 |
0.800 | -0.172 | 2 | 0.865 |
ZAK |
0.800 | -0.128 | 1 | 0.626 |
MEKK3 |
0.799 | -0.156 | 1 | 0.676 |
PRKX |
0.799 | -0.005 | -3 | 0.613 |
AURA |
0.798 | -0.058 | -2 | 0.545 |
PKG2 |
0.798 | -0.058 | -2 | 0.587 |
CAMKK1 |
0.798 | -0.001 | -2 | 0.795 |
MARK2 |
0.797 | -0.086 | 4 | 0.660 |
SGK3 |
0.797 | -0.059 | -3 | 0.695 |
MARK3 |
0.797 | -0.079 | 4 | 0.694 |
DCAMKL1 |
0.797 | -0.069 | -3 | 0.729 |
MSK1 |
0.796 | -0.079 | -3 | 0.682 |
PAK2 |
0.796 | -0.139 | -2 | 0.691 |
TAO2 |
0.796 | -0.015 | 2 | 0.897 |
TNIK |
0.795 | 0.051 | 3 | 0.872 |
TLK1 |
0.795 | -0.135 | -2 | 0.792 |
GCK |
0.794 | -0.001 | 1 | 0.699 |
PLK4 |
0.794 | -0.139 | 2 | 0.656 |
GSK3B |
0.794 | 0.025 | 4 | 0.441 |
CAMKK2 |
0.794 | -0.003 | -2 | 0.785 |
AKT1 |
0.794 | -0.017 | -3 | 0.635 |
HGK |
0.794 | 0.018 | 3 | 0.859 |
MYLK4 |
0.794 | -0.104 | -2 | 0.693 |
EEF2K |
0.794 | 0.010 | 3 | 0.835 |
DRAK1 |
0.794 | -0.151 | 1 | 0.637 |
MST2 |
0.794 | -0.044 | 1 | 0.691 |
IRAK4 |
0.793 | -0.118 | 1 | 0.598 |
NEK8 |
0.793 | -0.108 | 2 | 0.873 |
BUB1 |
0.793 | 0.122 | -5 | 0.803 |
LKB1 |
0.792 | 0.002 | -3 | 0.830 |
MAPKAPK5 |
0.792 | -0.136 | -3 | 0.652 |
WNK4 |
0.792 | -0.163 | -2 | 0.771 |
PKCT |
0.792 | -0.071 | 2 | 0.813 |
PHKG2 |
0.791 | -0.081 | -3 | 0.738 |
MARK1 |
0.791 | -0.122 | 4 | 0.721 |
GAK |
0.790 | -0.030 | 1 | 0.704 |
PASK |
0.790 | -0.075 | -3 | 0.823 |
MINK |
0.790 | -0.023 | 1 | 0.653 |
P70S6K |
0.789 | -0.068 | -3 | 0.638 |
PKCI |
0.789 | -0.049 | 2 | 0.816 |
CAMK1G |
0.788 | -0.117 | -3 | 0.700 |
CK1E |
0.788 | -0.069 | -3 | 0.534 |
NEK4 |
0.788 | -0.076 | 1 | 0.637 |
SSTK |
0.788 | -0.090 | 4 | 0.736 |
CK2A2 |
0.787 | -0.017 | 1 | 0.616 |
DCAMKL2 |
0.787 | -0.099 | -3 | 0.755 |
NEK11 |
0.787 | -0.167 | 1 | 0.676 |
SMMLCK |
0.787 | -0.113 | -3 | 0.765 |
SNRK |
0.787 | -0.248 | 2 | 0.720 |
PKCE |
0.786 | -0.013 | 2 | 0.792 |
PKACA |
0.786 | -0.049 | -2 | 0.541 |
MEKK6 |
0.786 | -0.089 | 1 | 0.660 |
MAP3K15 |
0.785 | -0.081 | 1 | 0.631 |
KHS1 |
0.785 | 0.012 | 1 | 0.664 |
KHS2 |
0.785 | 0.040 | 1 | 0.681 |
MST1 |
0.785 | -0.062 | 1 | 0.666 |
HPK1 |
0.784 | -0.035 | 1 | 0.684 |
GRK3 |
0.784 | -0.090 | -2 | 0.629 |
NEK1 |
0.784 | -0.043 | 1 | 0.626 |
LOK |
0.784 | -0.055 | -2 | 0.716 |
PDK1 |
0.783 | -0.110 | 1 | 0.660 |
SBK |
0.783 | 0.050 | -3 | 0.495 |
CAMK1D |
0.783 | -0.074 | -3 | 0.617 |
LRRK2 |
0.783 | -0.072 | 2 | 0.885 |
PAK5 |
0.782 | -0.078 | -2 | 0.580 |
CK1D |
0.782 | -0.049 | -3 | 0.483 |
TAK1 |
0.782 | -0.128 | 1 | 0.667 |
TTBK1 |
0.781 | -0.176 | 2 | 0.651 |
AKT3 |
0.780 | -0.024 | -3 | 0.550 |
PKN1 |
0.780 | -0.064 | -3 | 0.654 |
SLK |
0.780 | -0.067 | -2 | 0.669 |
PLK2 |
0.780 | -0.032 | -3 | 0.835 |
YSK1 |
0.779 | -0.051 | 2 | 0.875 |
DAPK3 |
0.779 | -0.091 | -3 | 0.743 |
CHK2 |
0.779 | -0.048 | -3 | 0.555 |
CK1G1 |
0.778 | -0.093 | -3 | 0.532 |
PBK |
0.778 | -0.027 | 1 | 0.651 |
PAK4 |
0.777 | -0.069 | -2 | 0.580 |
OSR1 |
0.777 | -0.029 | 2 | 0.849 |
VRK1 |
0.777 | -0.173 | 2 | 0.884 |
CK2A1 |
0.777 | -0.035 | 1 | 0.601 |
SGK1 |
0.776 | -0.028 | -3 | 0.531 |
MEK2 |
0.775 | -0.189 | 2 | 0.852 |
CAMK1A |
0.775 | -0.053 | -3 | 0.579 |
MRCKA |
0.774 | -0.060 | -3 | 0.693 |
IRAK1 |
0.774 | -0.271 | -1 | 0.713 |
BIKE |
0.774 | 0.025 | 1 | 0.611 |
MRCKB |
0.773 | -0.053 | -3 | 0.668 |
CK1A2 |
0.773 | -0.076 | -3 | 0.475 |
ROCK2 |
0.773 | -0.053 | -3 | 0.726 |
NEK3 |
0.771 | -0.103 | 1 | 0.619 |
DAPK1 |
0.771 | -0.104 | -3 | 0.719 |
TTK |
0.770 | -0.044 | -2 | 0.785 |
PDHK3_TYR |
0.769 | 0.204 | 4 | 0.866 |
MYO3B |
0.768 | -0.027 | 2 | 0.887 |
TAO1 |
0.767 | -0.042 | 1 | 0.619 |
MYO3A |
0.767 | -0.031 | 1 | 0.648 |
RIPK2 |
0.766 | -0.261 | 1 | 0.606 |
AAK1 |
0.765 | 0.069 | 1 | 0.539 |
HASPIN |
0.765 | -0.047 | -1 | 0.636 |
CRIK |
0.764 | -0.023 | -3 | 0.644 |
ASK1 |
0.763 | -0.113 | 1 | 0.619 |
STK33 |
0.762 | -0.196 | 2 | 0.630 |
DMPK1 |
0.762 | -0.040 | -3 | 0.695 |
TESK1_TYR |
0.760 | 0.012 | 3 | 0.847 |
ROCK1 |
0.759 | -0.067 | -3 | 0.684 |
PDHK4_TYR |
0.759 | 0.059 | 2 | 0.871 |
MAP2K4_TYR |
0.758 | -0.000 | -1 | 0.869 |
ALPHAK3 |
0.756 | -0.082 | -1 | 0.759 |
LIMK2_TYR |
0.756 | 0.069 | -3 | 0.874 |
MAP2K6_TYR |
0.756 | -0.014 | -1 | 0.865 |
PKMYT1_TYR |
0.755 | 0.015 | 3 | 0.792 |
MAP2K7_TYR |
0.753 | -0.139 | 2 | 0.871 |
PKG1 |
0.753 | -0.114 | -2 | 0.505 |
BMPR2_TYR |
0.752 | -0.014 | -1 | 0.846 |
PINK1_TYR |
0.752 | -0.114 | 1 | 0.704 |
PDHK1_TYR |
0.752 | -0.088 | -1 | 0.871 |
STLK3 |
0.751 | -0.174 | 1 | 0.616 |
TXK |
0.748 | 0.026 | 1 | 0.690 |
TYK2 |
0.747 | -0.120 | 1 | 0.652 |
LIMK1_TYR |
0.746 | -0.082 | 2 | 0.892 |
EPHB4 |
0.746 | -0.069 | -1 | 0.843 |
RET |
0.745 | -0.137 | 1 | 0.660 |
ROS1 |
0.745 | -0.101 | 3 | 0.715 |
EPHA6 |
0.745 | -0.067 | -1 | 0.844 |
ABL2 |
0.745 | -0.035 | -1 | 0.821 |
JAK2 |
0.743 | -0.108 | 1 | 0.654 |
TYRO3 |
0.743 | -0.129 | 3 | 0.748 |
YES1 |
0.742 | -0.062 | -1 | 0.845 |
MST1R |
0.741 | -0.151 | 3 | 0.744 |
CSF1R |
0.741 | -0.097 | 3 | 0.718 |
YANK3 |
0.741 | -0.112 | 2 | 0.378 |
ABL1 |
0.740 | -0.051 | -1 | 0.813 |
CK1A |
0.740 | -0.095 | -3 | 0.392 |
NEK10_TYR |
0.739 | -0.063 | 1 | 0.571 |
FGR |
0.739 | -0.138 | 1 | 0.683 |
TNNI3K_TYR |
0.739 | -0.018 | 1 | 0.644 |
LCK |
0.739 | -0.046 | -1 | 0.816 |
JAK1 |
0.738 | -0.042 | 1 | 0.625 |
HCK |
0.738 | -0.089 | -1 | 0.820 |
FER |
0.737 | -0.155 | 1 | 0.702 |
JAK3 |
0.736 | -0.147 | 1 | 0.647 |
BLK |
0.736 | -0.038 | -1 | 0.828 |
ITK |
0.735 | -0.089 | -1 | 0.794 |
INSRR |
0.735 | -0.138 | 3 | 0.659 |
TEC |
0.733 | -0.053 | -1 | 0.763 |
BMX |
0.732 | -0.069 | -1 | 0.737 |
EPHB1 |
0.732 | -0.142 | 1 | 0.689 |
BTK |
0.731 | -0.109 | -1 | 0.773 |
EPHB3 |
0.731 | -0.134 | -1 | 0.833 |
EPHA4 |
0.731 | -0.106 | 2 | 0.726 |
DDR1 |
0.731 | -0.232 | 4 | 0.767 |
SRMS |
0.730 | -0.148 | 1 | 0.687 |
PDGFRB |
0.730 | -0.198 | 3 | 0.737 |
FLT3 |
0.730 | -0.164 | 3 | 0.735 |
EPHB2 |
0.730 | -0.126 | -1 | 0.822 |
TNK2 |
0.729 | -0.150 | 3 | 0.655 |
FGFR2 |
0.729 | -0.141 | 3 | 0.694 |
TEK |
0.729 | -0.108 | 3 | 0.652 |
KIT |
0.728 | -0.163 | 3 | 0.715 |
MERTK |
0.728 | -0.124 | 3 | 0.687 |
TNK1 |
0.728 | -0.142 | 3 | 0.721 |
WEE1_TYR |
0.727 | -0.086 | -1 | 0.734 |
FGFR1 |
0.726 | -0.148 | 3 | 0.672 |
KDR |
0.725 | -0.161 | 3 | 0.666 |
FRK |
0.725 | -0.101 | -1 | 0.844 |
AXL |
0.725 | -0.178 | 3 | 0.692 |
PDGFRA |
0.725 | -0.214 | 3 | 0.734 |
FYN |
0.725 | -0.070 | -1 | 0.790 |
ALK |
0.724 | -0.164 | 3 | 0.617 |
PTK6 |
0.722 | -0.195 | -1 | 0.733 |
NTRK1 |
0.722 | -0.204 | -1 | 0.818 |
MET |
0.722 | -0.169 | 3 | 0.704 |
EPHA7 |
0.721 | -0.140 | 2 | 0.747 |
LTK |
0.720 | -0.172 | 3 | 0.639 |
LYN |
0.720 | -0.121 | 3 | 0.629 |
ERBB2 |
0.719 | -0.192 | 1 | 0.635 |
INSR |
0.719 | -0.179 | 3 | 0.649 |
CK1G3 |
0.719 | -0.097 | -3 | 0.341 |
EPHA1 |
0.718 | -0.167 | 3 | 0.682 |
NTRK2 |
0.718 | -0.221 | 3 | 0.660 |
NTRK3 |
0.717 | -0.166 | -1 | 0.781 |
EPHA3 |
0.717 | -0.170 | 2 | 0.713 |
FLT1 |
0.717 | -0.187 | -1 | 0.811 |
FGFR3 |
0.717 | -0.160 | 3 | 0.661 |
MATK |
0.716 | -0.127 | -1 | 0.741 |
PTK2B |
0.716 | -0.101 | -1 | 0.784 |
SRC |
0.715 | -0.113 | -1 | 0.801 |
EPHA5 |
0.714 | -0.144 | 2 | 0.715 |
EGFR |
0.714 | -0.111 | 1 | 0.559 |
FLT4 |
0.713 | -0.215 | 3 | 0.654 |
MUSK |
0.713 | -0.116 | 1 | 0.563 |
EPHA8 |
0.713 | -0.136 | -1 | 0.810 |
DDR2 |
0.710 | -0.138 | 3 | 0.622 |
YANK2 |
0.710 | -0.130 | 2 | 0.397 |
SYK |
0.708 | -0.088 | -1 | 0.751 |
CSK |
0.707 | -0.180 | 2 | 0.753 |
FGFR4 |
0.706 | -0.146 | -1 | 0.768 |
PTK2 |
0.705 | -0.091 | -1 | 0.747 |
IGF1R |
0.704 | -0.166 | 3 | 0.575 |
EPHA2 |
0.700 | -0.159 | -1 | 0.772 |
CK1G2 |
0.699 | -0.109 | -3 | 0.443 |
ERBB4 |
0.698 | -0.119 | 1 | 0.584 |
FES |
0.688 | -0.169 | -1 | 0.709 |
ZAP70 |
0.687 | -0.093 | -1 | 0.679 |