Motif 740 (n=198)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J1V8 | PPAN-P2RY11 | S364 | ochoa | HCG2039996 (PPAN-P2RY11 readthrough) | None |
| A5A3E0 | POTEF | S939 | ochoa | POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) | None |
| A5YM69 | ARHGEF35 | Y183 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| A6NDB9 | PALM3 | S375 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| F8WAN1 | SPECC1L-ADORA2A | S385 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| H7C1W4 | None | S397 | ochoa | Uncharacterized protein | None |
| O00160 | MYO1F | S734 | ochoa | Unconventional myosin-If (Myosin-Ie) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}. |
| O00273 | DFFA | S233 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O14737 | PDCD5 | S51 | ochoa | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | May function in the process of apoptosis. |
| O14777 | NDC80 | S165 | psp | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O14976 | GAK | S1176 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15234 | CASC3 | S117 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O15400 | STX7 | S174 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15516 | CLOCK | S408 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O43175 | PHGDH | S55 | ochoa|psp | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| O43379 | WDR62 | S1070 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43491 | EPB41L2 | S683 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43823 | AKAP8 | S328 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
| O60499 | STX10 | S108 | ochoa | Syntaxin-10 (Syn10) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O75113 | N4BP1 | S398 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O75121 | MFAP3L | S360 | ochoa | Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) | May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}. |
| O75146 | HIP1R | S592 | ochoa | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}. |
| O75665 | OFD1 | S954 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75683 | SURF6 | S138 | ochoa | Surfeit locus protein 6 | Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}. |
| O75815 | BCAR3 | S471 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O75976 | CPD | S1358 | ochoa | Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) | None |
| O95232 | LUC7L3 | S110 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| P02545 | LMNA | S277 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P05412 | JUN | S243 | ochoa|psp | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
| P0DMV8 | HSPA1A | S40 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S40 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P10451 | SPP1 | S280 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P10809 | HSPD1 | S225 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11055 | MYH3 | S1337 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11142 | HSPA8 | S40 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12882 | MYH1 | S1340 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | Y1308 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13535 | MYH8 | S1339 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14618 | PKM | S287 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P15311 | EZR | S535 | ochoa | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P17028 | ZNF24 | S291 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17029 | ZKSCAN1 | S445 | ochoa | Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18) | May be involved in transcriptional regulation. |
| P17066 | HSPA6 | S42 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P18858 | LIG1 | S229 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P20700 | LMNB1 | S278 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P21127 | CDK11B | S65 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P22732 | SLC2A5 | S242 | ochoa | Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5) | Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:17710649, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8333543}. |
| P29350 | PTPN6 | S250 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P33241 | LSP1 | S130 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P34931 | HSPA1L | S42 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35579 | MYH9 | T1155 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35609 | ACTN2 | S596 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35749 | MYH11 | T1162 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P39880 | CUX1 | S1270 | ochoa|psp | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P40337 | VHL | S68 | ochoa|psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
| P42695 | NCAPD3 | S1419 | psp | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P46013 | MKI67 | S2865 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P47712 | PLA2G4A | S435 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P47712 | PLA2G4A | S729 | ochoa | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| P48444 | ARCN1 | S189 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P48741 | HSPA7 | S42 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P51114 | FXR1 | S587 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P51608 | MECP2 | S53 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P51858 | HDGF | S165 | ochoa | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P52737 | ZNF136 | S292 | ochoa | Zinc finger protein 136 | May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain. |
| P52756 | RBM5 | S624 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
| P54652 | HSPA2 | S41 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P55010 | EIF5 | S410 | ochoa | Eukaryotic translation initiation factor 5 (eIF-5) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}. |
| P55884 | EIF3B | S152 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P55957 | BID | S67 | ochoa|psp | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P59923 | ZNF445 | S665 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| P60709 | ACTB | S239 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S241 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S239 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S240 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S241 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S241 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P98088 | MUC5AC | S1801 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| P98088 | MUC5AC | S3280 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| Q00341 | HDLBP | S804 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00587 | CDC42EP1 | S371 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q01362 | MS4A2 | S19 | ochoa | High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2) | High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. |
| Q03164 | KMT2A | S1115 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03252 | LMNB2 | S175 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q03252 | LMNB2 | S292 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q08945 | SSRP1 | S578 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q12888 | TP53BP1 | S1160 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12965 | MYO1E | S736 | ochoa | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}. |
| Q13310 | PABPC4 | S360 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13428 | TCOF1 | S110 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13501 | SQSTM1 | S332 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13813 | SPTAN1 | Y2423 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14204 | DYNC1H1 | S1230 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q15149 | PLEC | S2421 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S2791 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15910 | EZH2 | S412 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
| Q15911 | ZFHX3 | S1146 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16600 | ZNF239 | S191 | ochoa | Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) | May be involved in transcriptional regulation. |
| Q53F19 | NCBP3 | S73 | ochoa | Nuclear cap-binding protein subunit 3 (Protein ELG) | Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}. |
| Q562R1 | ACTBL2 | S240 | ochoa | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
| Q5JTH9 | RRP12 | S97 | ochoa | RRP12-like protein | None |
| Q5T1R4 | HIVEP3 | S739 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5P2 | KIAA1217 | S1292 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T5X7 | BEND3 | S39 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5TB80 | CEP162 | S145 | ochoa | Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}. |
| Q68DK2 | ZFYVE26 | S1893 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q69YQ0 | SPECC1L | S385 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6AWC2 | WWC2 | S851 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6DN90 | IQSEC1 | S253 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6NYC8 | PPP1R18 | S307 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6S8J3 | POTEE | S939 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6U7Q0 | ZNF322 | S83 | psp | Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) | Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZ89, ECO:0000269|PubMed:15555580}. |
| Q6WKZ4 | RAB11FIP1 | S501 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6XZF7 | DNMBP | S689 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q71F23 | CENPU | S158 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q76FK4 | NOL8 | S1042 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7Z4V5 | HDGFL2 | S599 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z5K2 | WAPL | S190 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6J4 | FGD2 | S22 | ochoa | FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). {ECO:0000250}. |
| Q7Z6J9 | TSEN54 | S76 | ochoa | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q7Z6Z7 | HUWE1 | S2362 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7L9 | ZSCAN2 | S318 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q86UP3 | ZFHX4 | S162 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86V48 | LUZP1 | S1042 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86W50 | METTL16 | S453 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q86WP2 | GPBP1 | S328 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q86XL3 | ANKLE2 | S806 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IWE4 | DCUN1D3 | S79 | ochoa | DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3) | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:18823379, PubMed:19617556, PubMed:23201271, PubMed:27542266). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:25349211, PubMed:26906416). {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:27542266}. |
| Q8N3J5 | PPM1K | S248 | ochoa | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715). {ECO:0000269|PubMed:17336929, ECO:0000269|PubMed:17374715, ECO:0000269|PubMed:19411760, ECO:0000269|PubMed:22291014, ECO:0000269|PubMed:22589535, ECO:0000269|PubMed:23086801, ECO:0000269|PubMed:29779826}. |
| Q8NBJ4 | GOLM1 | S191 | ochoa | Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) | Unknown. Cellular response protein to viral infection. |
| Q8NEJ9 | NGDN | S202 | ochoa | Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9DB96, ECO:0000269|PubMed:34516797}. |
| Q8TBA6 | GOLGA5 | S187 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TF32 | ZNF431 | S440 | ochoa | Zinc finger protein 431 | Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). {ECO:0000250}. |
| Q8TF47 | ZFP90 | S406 | ochoa | Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756) | Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. {ECO:0000269|PubMed:21284946}.; FUNCTION: [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}. |
| Q8WUM0 | NUP133 | S492 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q92504 | SLC39A7 | S293 | psp | Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7) | Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653, PubMed:29980658). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:22317921, PubMed:28205653, PubMed:29980658). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508). {ECO:0000250|UniProtKB:Q31125, ECO:0000269|PubMed:14525538, ECO:0000269|PubMed:15705588, ECO:0000269|PubMed:22317921, ECO:0000269|PubMed:28205653, ECO:0000269|PubMed:29980658, ECO:0000269|PubMed:30237509, ECO:0000269|PubMed:30718914, ECO:0000269|PubMed:33608508}. |
| Q92576 | PHF3 | S1084 | ochoa | PHD finger protein 3 | None |
| Q92625 | ANKS1A | S685 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92667 | AKAP1 | S330 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92817 | EVPL | S971 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
| Q92878 | RAD50 | S471 | ochoa | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q92878 | RAD50 | S635 | ochoa|psp | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q93075 | TATDN2 | S454 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q969G3 | SMARCE1 | S317 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96AC1 | FERMT2 | S328 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96RL1 | UIMC1 | S545 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96T23 | RSF1 | S516 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T51 | RUFY1 | S620 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q99549 | MPHOSPH8 | S51 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99550 | MPHOSPH9 | S931 | ochoa | M-phase phosphoprotein 9 | Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}. |
| Q99808 | SLC29A1 | S273 | ochoa | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
| Q9BRH9 | ZNF251 | S333 | ochoa | Zinc finger protein 251 | May be involved in transcriptional regulation. |
| Q9BYM8 | RBCK1 | S333 | ochoa | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9BYX7 | POTEKP | S239 | ochoa | Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K) | None |
| Q9C0D2 | CEP295 | S1205 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9H0G5 | NSRP1 | S146 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H6S0 | YTHDC2 | S1201 | ochoa | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}. |
| Q9H6U6 | BCAS3 | S871 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H9H4 | VPS37B | S100 | ochoa | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}. |
| Q9H9Q2 | COPS7B | S225 | ochoa | COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}. |
| Q9NQ55 | PPAN | S364 | ochoa | Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog) | May have a role in cell growth. |
| Q9NQW6 | ANLN | S362 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NUQ3 | TXLNG | S97 | ochoa | Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) | May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. {ECO:0000269|PubMed:15911876, ECO:0000269|PubMed:18068885}. |
| Q9NUQ8 | ABCF3 | S283 | ochoa | ATP-binding cassette sub-family F member 3 | Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}. |
| Q9NZ71 | RTEL1 | S300 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9NZB2 | FAM120A | S1041 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P2D1 | CHD7 | S2533 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2Y5 | UVRAG | S525 | ochoa | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UBW5 | BIN2 | S498 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UER7 | DAXX | S403 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UKV5 | AMFR | S542 | ochoa | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296). Required for proper lipid homeostasis (PubMed:37119330). {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:12670940, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:17043353, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:31073040, ECO:0000269|PubMed:31953408, ECO:0000269|PubMed:36593296, ECO:0000269|PubMed:37119330}. |
| Q9UKX2 | MYH2 | S1342 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UPN4 | CEP131 | S798 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPV7 | PHF24 | S73 | ochoa | PHD finger protein 24 | None |
| Q9UQ88 | CDK11A | S65 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2B0 | CNPY2 | S99 | ochoa | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| Q9Y2H9 | MAST1 | S827 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2I6 | NINL | S448 | psp | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y3B9 | RRP15 | S51 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y4D1 | DAAM1 | S1030 | ochoa | Disheveled-associated activator of morphogenesis 1 | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
| P61313 | RPL15 | S118 | Sugiyama | Large ribosomal subunit protein eL15 (60S ribosomal protein L15) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q01518 | CAP1 | S338 | Sugiyama | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q9NPQ8 | RIC8A | S452 | Sugiyama | Chaperone Ric-8A (Synembryn-A) | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}. |
| O43615 | TIMM44 | S94 | Sugiyama | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| P35606 | COPB2 | Y824 | Sugiyama | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| O14974 | PPP1R12A | S692 | Sugiyama | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| Q8TDY2 | RB1CC1 | S1323 | PSP | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| O15212 | PFDN6 | S101 | Sugiyama | Prefoldin subunit 6 (Protein Ke2) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| P05129 | PRKCG | S297 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| Q9NY33 | DPP3 | S194 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| Q9UK13 | ZNF221 | S238 | Sugiyama | Zinc finger protein 221 | May be involved in transcriptional regulation. |
| Q9BR84 | ZNF559 | S197 | Sugiyama | Zinc finger protein 559 | May be involved in transcriptional regulation. |
| Q15906 | VPS72 | S41 | ELM | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| Q9BZC7 | ABCA2 | S1113 | Sugiyama | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| O95786 | RIGI | S764 | EPSD|PSP | Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) | Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:24366338, PubMed:28469175, PubMed:29117565, PubMed:31006531, PubMed:34935440, PubMed:35263596, PubMed:36793726). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.74). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269|PubMed:15208624, ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:31006531, ECO:0000269|PubMed:34935440, ECO:0000269|PubMed:35263596, ECO:0000269|PubMed:36793726, ECO:0000269|Ref.74, ECO:0000303|PubMed:21616437, ECO:0000303|PubMed:21884169}. |
| Q13162 | PRDX4 | S65 | Sugiyama | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}. |
| O60763 | USO1 | S776 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| O00469 | PLOD2 | S597 | Sugiyama | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2) | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. {ECO:0000250|UniProtKB:P24802}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 3.330669e-16 | 15.477 |
| R-HSA-2262752 | Cellular responses to stress | 3.801981e-11 | 10.420 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.953580e-10 | 9.305 |
| R-HSA-1640170 | Cell Cycle | 1.630824e-05 | 4.788 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.371905e-05 | 4.625 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.712851e-04 | 3.766 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.512881e-04 | 3.600 |
| R-HSA-380287 | Centrosome maturation | 2.906911e-04 | 3.537 |
| R-HSA-390522 | Striated Muscle Contraction | 3.781668e-04 | 3.422 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 4.373817e-04 | 3.359 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.931741e-04 | 3.307 |
| R-HSA-1500931 | Cell-Cell communication | 6.270151e-04 | 3.203 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.437104e-04 | 3.191 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 7.899455e-04 | 3.102 |
| R-HSA-381070 | IRE1alpha activates chaperones | 9.168624e-04 | 3.038 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 9.744481e-04 | 3.011 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.162752e-03 | 2.935 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.162752e-03 | 2.935 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.100575e-03 | 2.958 |
| R-HSA-68886 | M Phase | 1.250101e-03 | 2.903 |
| R-HSA-75153 | Apoptotic execution phase | 1.432875e-03 | 2.844 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.500022e-03 | 2.824 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.644145e-03 | 2.784 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.644145e-03 | 2.784 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.713520e-03 | 2.766 |
| R-HSA-9659379 | Sensory processing of sound | 2.163934e-03 | 2.665 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.308961e-03 | 2.637 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.308961e-03 | 2.637 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 2.654012e-03 | 2.576 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.992089e-03 | 2.524 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.846252e-03 | 2.546 |
| R-HSA-199991 | Membrane Trafficking | 2.830653e-03 | 2.548 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.972457e-03 | 2.527 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.685137e-03 | 2.571 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.685137e-03 | 2.571 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.728175e-03 | 2.564 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.070134e-03 | 2.513 |
| R-HSA-68882 | Mitotic Anaphase | 3.258742e-03 | 2.487 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.356313e-03 | 2.474 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 3.784396e-03 | 2.422 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.057005e-03 | 2.392 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.594141e-03 | 2.338 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.594141e-03 | 2.338 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 5.100661e-03 | 2.292 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.451824e-03 | 2.263 |
| R-HSA-68877 | Mitotic Prometaphase | 5.083118e-03 | 2.294 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 5.213278e-03 | 2.283 |
| R-HSA-446728 | Cell junction organization | 5.760005e-03 | 2.240 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.553423e-03 | 2.255 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.865831e-03 | 2.232 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 6.597082e-03 | 2.181 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.268060e-03 | 2.083 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 1.010812e-02 | 1.995 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.010812e-02 | 1.995 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.097902e-02 | 1.959 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.045900e-02 | 1.981 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 1.010812e-02 | 1.995 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.045900e-02 | 1.981 |
| R-HSA-418990 | Adherens junctions interactions | 1.036644e-02 | 1.984 |
| R-HSA-9833482 | PKR-mediated signaling | 1.097902e-02 | 1.959 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 9.712793e-03 | 2.013 |
| R-HSA-196025 | Formation of annular gap junctions | 1.211192e-02 | 1.917 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.211192e-02 | 1.917 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.422180e-02 | 1.847 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.422180e-02 | 1.847 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.390618e-02 | 1.857 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.381324e-02 | 1.860 |
| R-HSA-69275 | G2/M Transition | 1.285413e-02 | 1.891 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.355032e-02 | 1.868 |
| R-HSA-190873 | Gap junction degradation | 1.427423e-02 | 1.845 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.427423e-02 | 1.845 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 1.658992e-02 | 1.780 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.612748e-02 | 1.792 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.612748e-02 | 1.792 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.606145e-02 | 1.794 |
| R-HSA-68875 | Mitotic Prophase | 1.630871e-02 | 1.788 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.606145e-02 | 1.794 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.579859e-02 | 1.801 |
| R-HSA-9612973 | Autophagy | 1.671455e-02 | 1.777 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.684801e-02 | 1.773 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.712817e-02 | 1.766 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.831841e-02 | 1.737 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.889982e-02 | 1.724 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.166164e-02 | 1.664 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.440800e-02 | 1.612 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.440800e-02 | 1.612 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.440800e-02 | 1.612 |
| R-HSA-397014 | Muscle contraction | 2.472723e-02 | 1.607 |
| R-HSA-421270 | Cell-cell junction organization | 2.202925e-02 | 1.657 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.487815e-02 | 1.604 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.523942e-02 | 1.598 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.949058e-02 | 1.530 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.949058e-02 | 1.530 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.949058e-02 | 1.530 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.949058e-02 | 1.530 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.949058e-02 | 1.530 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.709671e-02 | 1.567 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 2.949058e-02 | 1.530 |
| R-HSA-6798695 | Neutrophil degranulation | 2.916847e-02 | 1.535 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.672870e-02 | 1.573 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 2.949058e-02 | 1.530 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.728845e-02 | 1.564 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.538661e-02 | 1.595 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.029843e-02 | 1.519 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 3.029843e-02 | 1.519 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 3.029843e-02 | 1.519 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.314690e-02 | 1.480 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 3.343349e-02 | 1.476 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.546065e-02 | 1.450 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.577031e-02 | 1.446 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.659616e-02 | 1.437 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.916675e-02 | 1.407 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 4.006157e-02 | 1.397 |
| R-HSA-9675151 | Disorders of Developmental Biology | 4.006157e-02 | 1.397 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.226865e-02 | 1.374 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.587361e-02 | 1.338 |
| R-HSA-5693538 | Homology Directed Repair | 4.973927e-02 | 1.303 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.229003e-02 | 1.282 |
| R-HSA-437239 | Recycling pathway of L1 | 5.050730e-02 | 1.297 |
| R-HSA-1500620 | Meiosis | 5.229003e-02 | 1.282 |
| R-HSA-432142 | Platelet sensitization by LDL | 4.713909e-02 | 1.327 |
| R-HSA-373760 | L1CAM interactions | 4.716819e-02 | 1.326 |
| R-HSA-73886 | Chromosome Maintenance | 5.374795e-02 | 1.270 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 5.463403e-02 | 1.263 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 5.463403e-02 | 1.263 |
| R-HSA-373753 | Nephrin family interactions | 5.463403e-02 | 1.263 |
| R-HSA-109581 | Apoptosis | 5.520767e-02 | 1.258 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.760656e-02 | 1.240 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 5.811497e-02 | 1.236 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 5.852842e-02 | 1.233 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.159510e-02 | 1.210 |
| R-HSA-175474 | Assembly Of The HIV Virion | 6.251583e-02 | 1.204 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.463202e-02 | 1.190 |
| R-HSA-1221632 | Meiotic synapsis | 6.465819e-02 | 1.189 |
| R-HSA-445355 | Smooth Muscle Contraction | 6.465819e-02 | 1.189 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 7.075537e-02 | 1.150 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 7.932489e-02 | 1.101 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 8.372507e-02 | 1.077 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 8.372507e-02 | 1.077 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 7.932489e-02 | 1.101 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 7.932489e-02 | 1.101 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.322433e-02 | 1.135 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.973907e-02 | 1.157 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 8.319579e-02 | 1.080 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 7.932489e-02 | 1.101 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.841474e-02 | 1.165 |
| R-HSA-1474244 | Extracellular matrix organization | 8.359763e-02 | 1.078 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 8.819794e-02 | 1.055 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 8.819794e-02 | 1.055 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 9.948267e-02 | 1.002 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 1.260508e-01 | 0.899 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.390407e-01 | 0.857 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.390407e-01 | 0.857 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.518383e-01 | 0.819 |
| R-HSA-111995 | phospho-PLA2 pathway | 1.518383e-01 | 0.819 |
| R-HSA-9613354 | Lipophagy | 1.644464e-01 | 0.784 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.768679e-01 | 0.752 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.768679e-01 | 0.752 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.891055e-01 | 0.723 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.247417e-01 | 0.648 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 2.588181e-01 | 0.587 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 2.588181e-01 | 0.587 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 2.807027e-01 | 0.552 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.019438e-01 | 0.520 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.123289e-01 | 0.505 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.123289e-01 | 0.505 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.123289e-01 | 0.505 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.123289e-01 | 0.505 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.886450e-01 | 0.724 |
| R-HSA-774815 | Nucleosome assembly | 1.886450e-01 | 0.724 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.326398e-01 | 0.478 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.326398e-01 | 0.478 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 3.523532e-01 | 0.453 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.487024e-01 | 0.604 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.707650e-01 | 0.567 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.680855e-01 | 0.572 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.419914e-01 | 0.466 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.162503e-01 | 0.665 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 9.118779e-02 | 1.040 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.919369e-01 | 0.535 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 9.948267e-02 | 1.002 |
| R-HSA-72172 | mRNA Splicing | 2.461730e-01 | 0.609 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.158055e-01 | 0.936 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.011619e-01 | 0.696 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.067551e-01 | 0.972 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.413593e-01 | 0.850 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.914025e-01 | 0.536 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.673301e-01 | 0.776 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.212912e-01 | 0.916 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.644464e-01 | 0.784 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.768679e-01 | 0.752 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.673301e-01 | 0.776 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.940319e-01 | 0.712 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.940319e-01 | 0.712 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.940319e-01 | 0.712 |
| R-HSA-1268020 | Mitochondrial protein import | 2.817947e-01 | 0.550 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.085416e-01 | 0.511 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.085416e-01 | 0.511 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.698420e-01 | 0.569 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.092902e-01 | 0.510 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.011619e-01 | 0.696 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.011619e-01 | 0.696 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.247417e-01 | 0.648 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.247417e-01 | 0.648 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 9.734935e-02 | 1.012 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.067551e-01 | 0.972 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.362763e-01 | 0.866 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.914025e-01 | 0.536 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.914025e-01 | 0.536 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.326398e-01 | 0.478 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.817947e-01 | 0.550 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.914025e-01 | 0.536 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.476283e-01 | 0.606 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.130397e-01 | 0.672 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.940319e-01 | 0.712 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.858553e-01 | 0.731 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.518383e-01 | 0.819 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.312356e-01 | 0.882 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.940319e-01 | 0.712 |
| R-HSA-8951664 | Neddylation | 1.553681e-01 | 0.809 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.128658e-01 | 0.947 |
| R-HSA-8981373 | Intestinal hexose absorption | 1.128658e-01 | 0.947 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.768679e-01 | 0.752 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.891055e-01 | 0.723 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 2.011619e-01 | 0.696 |
| R-HSA-1483115 | Hydrolysis of LPC | 2.362704e-01 | 0.627 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.807027e-01 | 0.552 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.914025e-01 | 0.536 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.006805e-01 | 0.997 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.123289e-01 | 0.505 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.225602e-01 | 0.491 |
| R-HSA-157579 | Telomere Maintenance | 2.205372e-01 | 0.657 |
| R-HSA-1632852 | Macroautophagy | 9.049914e-02 | 1.043 |
| R-HSA-9664873 | Pexophagy | 1.768679e-01 | 0.752 |
| R-HSA-9663891 | Selective autophagy | 1.787240e-01 | 0.748 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.011619e-01 | 0.696 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.516433e-01 | 0.819 |
| R-HSA-9609646 | HCMV Infection | 2.199989e-01 | 0.658 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.362704e-01 | 0.627 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.817947e-01 | 0.550 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.561582e-01 | 0.591 |
| R-HSA-114608 | Platelet degranulation | 3.573152e-01 | 0.447 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.195114e-01 | 0.659 |
| R-HSA-73894 | DNA Repair | 2.121393e-01 | 0.673 |
| R-HSA-9927353 | Co-inhibition by BTLA | 9.948267e-02 | 1.002 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 2.130397e-01 | 0.672 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.130397e-01 | 0.672 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.130397e-01 | 0.672 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.194925e-01 | 0.923 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.326398e-01 | 0.478 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.073334e-01 | 0.969 |
| R-HSA-180786 | Extension of Telomeres | 2.652479e-01 | 0.576 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.132700e-01 | 0.671 |
| R-HSA-4839726 | Chromatin organization | 2.176302e-01 | 0.662 |
| R-HSA-2559583 | Cellular Senescence | 1.800329e-01 | 0.745 |
| R-HSA-73887 | Death Receptor Signaling | 2.578926e-01 | 0.589 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.101683e-01 | 0.677 |
| R-HSA-9664407 | Parasite infection | 2.101683e-01 | 0.677 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.101683e-01 | 0.677 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.166130e-01 | 0.933 |
| R-HSA-8964011 | HDL clearance | 1.260508e-01 | 0.899 |
| R-HSA-447041 | CHL1 interactions | 1.390407e-01 | 0.857 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.891055e-01 | 0.723 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.476283e-01 | 0.606 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.212912e-01 | 0.916 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.588181e-01 | 0.587 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.673301e-01 | 0.776 |
| R-HSA-190828 | Gap junction trafficking | 1.832795e-01 | 0.737 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.425701e-01 | 0.465 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.707650e-01 | 0.567 |
| R-HSA-3214847 | HATs acetylate histones | 2.283485e-01 | 0.641 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.401608e-01 | 0.619 |
| R-HSA-162587 | HIV Life Cycle | 1.242069e-01 | 0.906 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.527894e-01 | 0.452 |
| R-HSA-111996 | Ca-dependent events | 1.726201e-01 | 0.763 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.588181e-01 | 0.587 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.620693e-01 | 0.790 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 3.523532e-01 | 0.453 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.283485e-01 | 0.641 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.227467e-01 | 0.911 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.886450e-01 | 0.724 |
| R-HSA-8963676 | Intestinal absorption | 1.518383e-01 | 0.819 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.644464e-01 | 0.784 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.247417e-01 | 0.648 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 3.123289e-01 | 0.505 |
| R-HSA-9755088 | Ribavirin ADME | 3.326398e-01 | 0.478 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.103031e-01 | 0.677 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.523532e-01 | 0.453 |
| R-HSA-5617833 | Cilium Assembly | 9.602143e-02 | 1.018 |
| R-HSA-112043 | PLC beta mediated events | 2.762810e-01 | 0.559 |
| R-HSA-162906 | HIV Infection | 3.116736e-01 | 0.506 |
| R-HSA-210990 | PECAM1 interactions | 1.891055e-01 | 0.723 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.362704e-01 | 0.627 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.476283e-01 | 0.606 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.487024e-01 | 0.604 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.276443e-01 | 0.485 |
| R-HSA-74160 | Gene expression (Transcription) | 2.913794e-01 | 0.536 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.227467e-01 | 0.911 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.711547e-01 | 0.567 |
| R-HSA-70171 | Glycolysis | 2.322738e-01 | 0.634 |
| R-HSA-212436 | Generic Transcription Pathway | 1.929558e-01 | 0.715 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.362704e-01 | 0.627 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.130832e-01 | 0.947 |
| R-HSA-977347 | Serine metabolism | 3.326398e-01 | 0.478 |
| R-HSA-69481 | G2/M Checkpoints | 1.654015e-01 | 0.781 |
| R-HSA-112040 | G-protein mediated events | 3.092902e-01 | 0.510 |
| R-HSA-9707616 | Heme signaling | 2.817947e-01 | 0.550 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.527894e-01 | 0.452 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.832349e-01 | 0.737 |
| R-HSA-5357801 | Programmed Cell Death | 1.239343e-01 | 0.907 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.891055e-01 | 0.723 |
| R-HSA-8876725 | Protein methylation | 2.476283e-01 | 0.606 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.588181e-01 | 0.587 |
| R-HSA-9664420 | Killing mechanisms | 2.588181e-01 | 0.587 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.807027e-01 | 0.552 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.994384e-01 | 0.700 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.560637e-01 | 0.592 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.362704e-01 | 0.627 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.807027e-01 | 0.552 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 3.225602e-01 | 0.491 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 3.326398e-01 | 0.478 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.605161e-01 | 0.794 |
| R-HSA-913531 | Interferon Signaling | 2.607237e-01 | 0.584 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.019438e-01 | 0.520 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.225602e-01 | 0.491 |
| R-HSA-1474165 | Reproduction | 1.769886e-01 | 0.752 |
| R-HSA-422475 | Axon guidance | 2.303887e-01 | 0.638 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.791547e-01 | 0.554 |
| R-HSA-168249 | Innate Immune System | 2.889213e-01 | 0.539 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 2.362704e-01 | 0.627 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.326398e-01 | 0.478 |
| R-HSA-9675108 | Nervous system development | 2.946828e-01 | 0.531 |
| R-HSA-435354 | Zinc transporters | 2.362704e-01 | 0.627 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.365711e-01 | 0.473 |
| R-HSA-70326 | Glucose metabolism | 3.126063e-01 | 0.505 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.020219e-01 | 0.991 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.523532e-01 | 0.453 |
| R-HSA-8983711 | OAS antiviral response | 2.130397e-01 | 0.672 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.205372e-01 | 0.657 |
| R-HSA-5358508 | Mismatch Repair | 2.914025e-01 | 0.536 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.449383e-01 | 0.611 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.473978e-01 | 0.459 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.247417e-01 | 0.648 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.807027e-01 | 0.552 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.832795e-01 | 0.737 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.513975e-01 | 0.600 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.362704e-01 | 0.627 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.832795e-01 | 0.737 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.019438e-01 | 0.520 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.914025e-01 | 0.536 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 3.527894e-01 | 0.452 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.425701e-01 | 0.465 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.983109e-01 | 0.525 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 2.597309e-01 | 0.585 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.225602e-01 | 0.491 |
| R-HSA-373755 | Semaphorin interactions | 2.873050e-01 | 0.542 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.581656e-01 | 0.446 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.619913e-01 | 0.441 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 3.619913e-01 | 0.441 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.688688e-01 | 0.433 |
| R-HSA-4086400 | PCP/CE pathway | 3.688688e-01 | 0.433 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.688688e-01 | 0.433 |
| R-HSA-9620244 | Long-term potentiation | 3.714866e-01 | 0.430 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.714866e-01 | 0.430 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.808412e-01 | 0.419 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.808412e-01 | 0.419 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.808412e-01 | 0.419 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.808412e-01 | 0.419 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.808412e-01 | 0.419 |
| R-HSA-9909396 | Circadian clock | 3.815678e-01 | 0.418 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.900571e-01 | 0.409 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.900571e-01 | 0.409 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.900571e-01 | 0.409 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 3.900571e-01 | 0.409 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.900571e-01 | 0.409 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 3.900571e-01 | 0.409 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.900592e-01 | 0.409 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.991363e-01 | 0.399 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.991363e-01 | 0.399 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.991363e-01 | 0.399 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.991363e-01 | 0.399 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.997228e-01 | 0.398 |
| R-HSA-9609690 | HCMV Early Events | 4.017468e-01 | 0.396 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.080810e-01 | 0.389 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.080810e-01 | 0.389 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.151247e-01 | 0.382 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.160924e-01 | 0.381 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.168931e-01 | 0.380 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.168931e-01 | 0.380 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.168931e-01 | 0.380 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.212330e-01 | 0.375 |
| R-HSA-70268 | Pyruvate metabolism | 4.212330e-01 | 0.375 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.212330e-01 | 0.375 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.251160e-01 | 0.371 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.255745e-01 | 0.371 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.255745e-01 | 0.371 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.255745e-01 | 0.371 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.255745e-01 | 0.371 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.255745e-01 | 0.371 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.293903e-01 | 0.367 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.341272e-01 | 0.362 |
| R-HSA-69190 | DNA strand elongation | 4.341272e-01 | 0.362 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.425531e-01 | 0.354 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.425531e-01 | 0.354 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.425531e-01 | 0.354 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.425531e-01 | 0.354 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.425531e-01 | 0.354 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.425531e-01 | 0.354 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.425531e-01 | 0.354 |
| R-HSA-9930044 | Nuclear RNA decay | 4.425531e-01 | 0.354 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.425531e-01 | 0.354 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.508540e-01 | 0.346 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.508540e-01 | 0.346 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 4.508540e-01 | 0.346 |
| R-HSA-391251 | Protein folding | 4.515752e-01 | 0.345 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.590318e-01 | 0.338 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.590318e-01 | 0.338 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.590318e-01 | 0.338 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.590318e-01 | 0.338 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.590318e-01 | 0.338 |
| R-HSA-5205647 | Mitophagy | 4.590318e-01 | 0.338 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.590318e-01 | 0.338 |
| R-HSA-392518 | Signal amplification | 4.590318e-01 | 0.338 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.613508e-01 | 0.336 |
| R-HSA-1474290 | Collagen formation | 4.614887e-01 | 0.336 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.643870e-01 | 0.333 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.670884e-01 | 0.331 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.670884e-01 | 0.331 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 4.670884e-01 | 0.331 |
| R-HSA-9658195 | Leishmania infection | 4.697121e-01 | 0.328 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.697121e-01 | 0.328 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.712973e-01 | 0.327 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.750254e-01 | 0.323 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.750254e-01 | 0.323 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.750254e-01 | 0.323 |
| R-HSA-111933 | Calmodulin induced events | 4.750254e-01 | 0.323 |
| R-HSA-111997 | CaM pathway | 4.750254e-01 | 0.323 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.750254e-01 | 0.323 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.761615e-01 | 0.322 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.828447e-01 | 0.316 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.828447e-01 | 0.316 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.828447e-01 | 0.316 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.858081e-01 | 0.314 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.858081e-01 | 0.314 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.858081e-01 | 0.314 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.858081e-01 | 0.314 |
| R-HSA-9610379 | HCMV Late Events | 4.871943e-01 | 0.312 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.905481e-01 | 0.309 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.905481e-01 | 0.309 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.952082e-01 | 0.305 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.981371e-01 | 0.303 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.981371e-01 | 0.303 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.981371e-01 | 0.303 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.981371e-01 | 0.303 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.981371e-01 | 0.303 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.981371e-01 | 0.303 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.981371e-01 | 0.303 |
| R-HSA-201556 | Signaling by ALK | 4.981371e-01 | 0.303 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.981371e-01 | 0.303 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.984223e-01 | 0.302 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.000700e-01 | 0.301 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.056136e-01 | 0.296 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.056136e-01 | 0.296 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.056136e-01 | 0.296 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.056136e-01 | 0.296 |
| R-HSA-9646399 | Aggrephagy | 5.056136e-01 | 0.296 |
| R-HSA-167169 | HIV Transcription Elongation | 5.056136e-01 | 0.296 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.056136e-01 | 0.296 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.056136e-01 | 0.296 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.056136e-01 | 0.296 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.094169e-01 | 0.293 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.129791e-01 | 0.290 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.129791e-01 | 0.290 |
| R-HSA-111885 | Opioid Signalling | 5.140768e-01 | 0.289 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.186881e-01 | 0.285 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.186881e-01 | 0.285 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.202354e-01 | 0.284 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.202354e-01 | 0.284 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.202354e-01 | 0.284 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.232703e-01 | 0.281 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.273839e-01 | 0.278 |
| R-HSA-418346 | Platelet homeostasis | 5.278233e-01 | 0.278 |
| R-HSA-9710421 | Defective pyroptosis | 5.344264e-01 | 0.272 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.344264e-01 | 0.272 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.368410e-01 | 0.270 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.368410e-01 | 0.270 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.413054e-01 | 0.267 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.413644e-01 | 0.267 |
| R-HSA-373752 | Netrin-1 signaling | 5.413644e-01 | 0.267 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.455823e-01 | 0.263 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.457400e-01 | 0.263 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.457400e-01 | 0.263 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.481994e-01 | 0.261 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.481994e-01 | 0.261 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.545196e-01 | 0.256 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.545196e-01 | 0.256 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.545196e-01 | 0.256 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.549330e-01 | 0.256 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 5.549330e-01 | 0.256 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.549330e-01 | 0.256 |
| R-HSA-9675135 | Diseases of DNA repair | 5.549330e-01 | 0.256 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.549330e-01 | 0.256 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.549330e-01 | 0.256 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.560968e-01 | 0.255 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.560968e-01 | 0.255 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.588644e-01 | 0.253 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.615667e-01 | 0.251 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.615667e-01 | 0.251 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.674635e-01 | 0.246 |
| R-HSA-425410 | Metal ion SLC transporters | 5.681018e-01 | 0.246 |
| R-HSA-168255 | Influenza Infection | 5.698890e-01 | 0.244 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.717176e-01 | 0.243 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.745400e-01 | 0.241 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.759415e-01 | 0.240 |
| R-HSA-9748787 | Azathioprine ADME | 5.808825e-01 | 0.236 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.871309e-01 | 0.231 |
| R-HSA-912446 | Meiotic recombination | 5.871309e-01 | 0.231 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 5.871309e-01 | 0.231 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.925334e-01 | 0.227 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.925334e-01 | 0.227 |
| R-HSA-72187 | mRNA 3'-end processing | 5.932866e-01 | 0.227 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.932866e-01 | 0.227 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.932866e-01 | 0.227 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.932866e-01 | 0.227 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.934774e-01 | 0.227 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.993508e-01 | 0.222 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.993508e-01 | 0.222 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.006467e-01 | 0.221 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.046578e-01 | 0.218 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.046578e-01 | 0.218 |
| R-HSA-72649 | Translation initiation complex formation | 6.053250e-01 | 0.218 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.086383e-01 | 0.216 |
| R-HSA-418597 | G alpha (z) signalling events | 6.112104e-01 | 0.214 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.131310e-01 | 0.212 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.170085e-01 | 0.210 |
| R-HSA-75893 | TNF signaling | 6.170085e-01 | 0.210 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.170085e-01 | 0.210 |
| R-HSA-177929 | Signaling by EGFR | 6.170085e-01 | 0.210 |
| R-HSA-194138 | Signaling by VEGF | 6.203977e-01 | 0.207 |
| R-HSA-1483166 | Synthesis of PA | 6.227204e-01 | 0.206 |
| R-HSA-5621480 | Dectin-2 family | 6.227204e-01 | 0.206 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.283475e-01 | 0.202 |
| R-HSA-449147 | Signaling by Interleukins | 6.327076e-01 | 0.199 |
| R-HSA-191859 | snRNP Assembly | 6.338910e-01 | 0.198 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.338910e-01 | 0.198 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.338910e-01 | 0.198 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.440136e-01 | 0.191 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.447322e-01 | 0.191 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.447322e-01 | 0.191 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.447322e-01 | 0.191 |
| R-HSA-450294 | MAP kinase activation | 6.447322e-01 | 0.191 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.487144e-01 | 0.188 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.500323e-01 | 0.187 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.500323e-01 | 0.187 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.500323e-01 | 0.187 |
| R-HSA-186797 | Signaling by PDGF | 6.500323e-01 | 0.187 |
| R-HSA-8963743 | Digestion and absorption | 6.552537e-01 | 0.184 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 6.603975e-01 | 0.180 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.634423e-01 | 0.178 |
| R-HSA-1234174 | Cellular response to hypoxia | 6.654648e-01 | 0.177 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.682194e-01 | 0.175 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.716896e-01 | 0.173 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.751176e-01 | 0.171 |
| R-HSA-6807070 | PTEN Regulation | 6.785420e-01 | 0.168 |
| R-HSA-913709 | O-linked glycosylation of mucins | 6.802195e-01 | 0.167 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.802195e-01 | 0.167 |
| R-HSA-167172 | Transcription of the HIV genome | 6.802195e-01 | 0.167 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.802195e-01 | 0.167 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.808236e-01 | 0.167 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.896940e-01 | 0.161 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.896940e-01 | 0.161 |
| R-HSA-448424 | Interleukin-17 signaling | 6.896940e-01 | 0.161 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 6.943260e-01 | 0.158 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.943260e-01 | 0.158 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.975725e-01 | 0.156 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.988890e-01 | 0.156 |
| R-HSA-597592 | Post-translational protein modification | 7.045064e-01 | 0.152 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.078126e-01 | 0.150 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 7.078126e-01 | 0.150 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.078126e-01 | 0.150 |
| R-HSA-69242 | S Phase | 7.110744e-01 | 0.148 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.110744e-01 | 0.148 |
| R-HSA-5689603 | UCH proteinases | 7.164729e-01 | 0.145 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.232985e-01 | 0.141 |
| R-HSA-216083 | Integrin cell surface interactions | 7.248774e-01 | 0.140 |
| R-HSA-9609507 | Protein localization | 7.262858e-01 | 0.139 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.292458e-01 | 0.137 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.321788e-01 | 0.135 |
| R-HSA-6806834 | Signaling by MET | 7.330339e-01 | 0.135 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.369562e-01 | 0.133 |
| R-HSA-8953854 | Metabolism of RNA | 7.386281e-01 | 0.132 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.409495e-01 | 0.130 |
| R-HSA-9824446 | Viral Infection Pathways | 7.425505e-01 | 0.129 |
| R-HSA-157118 | Signaling by NOTCH | 7.478945e-01 | 0.126 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.486313e-01 | 0.126 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 7.523867e-01 | 0.124 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.523867e-01 | 0.124 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.633210e-01 | 0.117 |
| R-HSA-156902 | Peptide chain elongation | 7.668579e-01 | 0.115 |
| R-HSA-73884 | Base Excision Repair | 7.737744e-01 | 0.111 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.737744e-01 | 0.111 |
| R-HSA-72306 | tRNA processing | 7.755490e-01 | 0.110 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.771557e-01 | 0.109 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.771557e-01 | 0.109 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.804866e-01 | 0.108 |
| R-HSA-5688426 | Deubiquitination | 7.808764e-01 | 0.107 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.837679e-01 | 0.106 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.837679e-01 | 0.106 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.870004e-01 | 0.104 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.901848e-01 | 0.102 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.933217e-01 | 0.101 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.933217e-01 | 0.101 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.964120e-01 | 0.099 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.964120e-01 | 0.099 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 7.994562e-01 | 0.097 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.065221e-01 | 0.093 |
| R-HSA-382556 | ABC-family proteins mediated transport | 8.111865e-01 | 0.091 |
| R-HSA-5610787 | Hedgehog 'off' state | 8.111865e-01 | 0.091 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.140106e-01 | 0.089 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.167927e-01 | 0.088 |
| R-HSA-1483255 | PI Metabolism | 8.167927e-01 | 0.088 |
| R-HSA-192823 | Viral mRNA Translation | 8.195334e-01 | 0.086 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.222332e-01 | 0.085 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.222332e-01 | 0.085 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.231048e-01 | 0.085 |
| R-HSA-9833110 | RSV-host interactions | 8.248929e-01 | 0.084 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.251272e-01 | 0.083 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.300938e-01 | 0.081 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.326363e-01 | 0.080 |
| R-HSA-69239 | Synthesis of DNA | 8.326363e-01 | 0.080 |
| R-HSA-211000 | Gene Silencing by RNA | 8.326363e-01 | 0.080 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.447914e-01 | 0.073 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.460432e-01 | 0.073 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.471148e-01 | 0.072 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.494036e-01 | 0.071 |
| R-HSA-109582 | Hemostasis | 8.547183e-01 | 0.068 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.560672e-01 | 0.067 |
| R-HSA-909733 | Interferon alpha/beta signaling | 8.560672e-01 | 0.067 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.562391e-01 | 0.067 |
| R-HSA-168256 | Immune System | 8.589009e-01 | 0.066 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.630650e-01 | 0.064 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.644974e-01 | 0.063 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.743469e-01 | 0.058 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.743469e-01 | 0.058 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.840161e-01 | 0.054 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.887462e-01 | 0.051 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.919577e-01 | 0.050 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.998183e-01 | 0.046 |
| R-HSA-5173105 | O-linked glycosylation | 9.013206e-01 | 0.045 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.028006e-01 | 0.044 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.028006e-01 | 0.044 |
| R-HSA-5663205 | Infectious disease | 9.032796e-01 | 0.044 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.089138e-01 | 0.041 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.125594e-01 | 0.040 |
| R-HSA-2142753 | Arachidonate metabolism | 9.225228e-01 | 0.035 |
| R-HSA-69306 | DNA Replication | 9.236859e-01 | 0.034 |
| R-HSA-1989781 | PPARA activates gene expression | 9.259603e-01 | 0.033 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.281671e-01 | 0.032 |
| R-HSA-9711097 | Cellular response to starvation | 9.292458e-01 | 0.032 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.292458e-01 | 0.032 |
| R-HSA-877300 | Interferon gamma signaling | 9.303084e-01 | 0.031 |
| R-HSA-9679506 | SARS-CoV Infections | 9.342395e-01 | 0.030 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.353877e-01 | 0.029 |
| R-HSA-112316 | Neuronal System | 9.362423e-01 | 0.029 |
| R-HSA-162582 | Signal Transduction | 9.364640e-01 | 0.029 |
| R-HSA-5619102 | SLC transporter disorders | 9.382565e-01 | 0.028 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.418851e-01 | 0.026 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.427586e-01 | 0.026 |
| R-HSA-1643685 | Disease | 9.433602e-01 | 0.025 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.444666e-01 | 0.025 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.444666e-01 | 0.025 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.444666e-01 | 0.025 |
| R-HSA-392499 | Metabolism of proteins | 9.488147e-01 | 0.023 |
| R-HSA-1483257 | Phospholipid metabolism | 9.503002e-01 | 0.022 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.503002e-01 | 0.022 |
| R-HSA-195721 | Signaling by WNT | 9.521432e-01 | 0.021 |
| R-HSA-3781865 | Diseases of glycosylation | 9.529922e-01 | 0.021 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.557579e-01 | 0.020 |
| R-HSA-1280218 | Adaptive Immune System | 9.609973e-01 | 0.017 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.621960e-01 | 0.017 |
| R-HSA-428157 | Sphingolipid metabolism | 9.636751e-01 | 0.016 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.647610e-01 | 0.016 |
| R-HSA-72766 | Translation | 9.656190e-01 | 0.015 |
| R-HSA-1266738 | Developmental Biology | 9.658616e-01 | 0.015 |
| R-HSA-6805567 | Keratinization | 9.668367e-01 | 0.015 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.723565e-01 | 0.012 |
| R-HSA-9748784 | Drug ADME | 9.723611e-01 | 0.012 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.745493e-01 | 0.011 |
| R-HSA-72312 | rRNA processing | 9.776581e-01 | 0.010 |
| R-HSA-8939211 | ESR-mediated signaling | 9.792939e-01 | 0.009 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.792939e-01 | 0.009 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.822161e-01 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.868844e-01 | 0.006 |
| R-HSA-418594 | G alpha (i) signalling events | 9.885138e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.912037e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.965116e-01 | 0.002 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.969764e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.979200e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.984848e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.992511e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.993442e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998863e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999999e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.878 | 0.335 | 1 | 0.853 |
COT |
0.877 | 0.227 | 2 | 0.900 |
KIS |
0.862 | 0.217 | 1 | 0.759 |
SRPK1 |
0.862 | 0.218 | -3 | 0.734 |
PIM3 |
0.861 | 0.118 | -3 | 0.800 |
DSTYK |
0.860 | 0.155 | 2 | 0.899 |
NDR2 |
0.858 | 0.084 | -3 | 0.794 |
MOS |
0.858 | 0.105 | 1 | 0.843 |
CLK2 |
0.856 | 0.299 | -3 | 0.730 |
SRPK2 |
0.856 | 0.197 | -3 | 0.661 |
GRK1 |
0.854 | 0.151 | -2 | 0.796 |
NLK |
0.854 | 0.138 | 1 | 0.847 |
PRPK |
0.854 | -0.076 | -1 | 0.839 |
RSK2 |
0.853 | 0.144 | -3 | 0.752 |
CAMK1B |
0.853 | 0.067 | -3 | 0.839 |
CDC7 |
0.852 | -0.025 | 1 | 0.796 |
NDR1 |
0.852 | 0.095 | -3 | 0.794 |
SRPK3 |
0.851 | 0.196 | -3 | 0.709 |
TGFBR2 |
0.851 | 0.155 | -2 | 0.920 |
IKKB |
0.851 | -0.045 | -2 | 0.725 |
PIM1 |
0.851 | 0.140 | -3 | 0.752 |
RAF1 |
0.851 | -0.034 | 1 | 0.785 |
SKMLCK |
0.850 | 0.131 | -2 | 0.864 |
CDKL1 |
0.849 | 0.072 | -3 | 0.784 |
CAMK2G |
0.849 | -0.007 | 2 | 0.858 |
BMPR2 |
0.849 | 0.011 | -2 | 0.898 |
NEK7 |
0.849 | 0.037 | -3 | 0.848 |
GCN2 |
0.849 | -0.096 | 2 | 0.824 |
NEK6 |
0.848 | 0.054 | -2 | 0.891 |
BMPR1B |
0.848 | 0.247 | 1 | 0.763 |
MTOR |
0.848 | -0.088 | 1 | 0.769 |
TBK1 |
0.847 | -0.063 | 1 | 0.691 |
TGFBR1 |
0.847 | 0.269 | -2 | 0.914 |
LATS2 |
0.847 | 0.077 | -5 | 0.754 |
ERK5 |
0.847 | 0.082 | 1 | 0.837 |
HIPK4 |
0.846 | 0.119 | 1 | 0.811 |
PKN3 |
0.846 | 0.026 | -3 | 0.795 |
ATR |
0.846 | -0.035 | 1 | 0.759 |
P90RSK |
0.846 | 0.091 | -3 | 0.755 |
P70S6KB |
0.845 | 0.106 | -3 | 0.773 |
CAMLCK |
0.845 | 0.096 | -2 | 0.857 |
PKACG |
0.845 | 0.117 | -2 | 0.783 |
FAM20C |
0.845 | 0.195 | 2 | 0.720 |
CLK4 |
0.845 | 0.203 | -3 | 0.746 |
CHAK2 |
0.845 | 0.038 | -1 | 0.851 |
ULK2 |
0.845 | -0.105 | 2 | 0.811 |
CDKL5 |
0.845 | 0.081 | -3 | 0.776 |
ICK |
0.845 | 0.101 | -3 | 0.814 |
ALK4 |
0.844 | 0.234 | -2 | 0.923 |
PDHK4 |
0.844 | -0.249 | 1 | 0.811 |
NIK |
0.844 | 0.013 | -3 | 0.848 |
RSK3 |
0.844 | 0.088 | -3 | 0.747 |
LATS1 |
0.843 | 0.164 | -3 | 0.803 |
AURC |
0.843 | 0.149 | -2 | 0.716 |
DAPK2 |
0.843 | 0.070 | -3 | 0.843 |
IKKE |
0.842 | -0.091 | 1 | 0.688 |
DYRK2 |
0.842 | 0.180 | 1 | 0.778 |
PRKD1 |
0.842 | 0.041 | -3 | 0.790 |
PRKD2 |
0.842 | 0.085 | -3 | 0.744 |
GRK6 |
0.842 | 0.018 | 1 | 0.830 |
IKKA |
0.842 | -0.003 | -2 | 0.716 |
RSK4 |
0.841 | 0.149 | -3 | 0.719 |
GRK5 |
0.841 | -0.105 | -3 | 0.808 |
PKACB |
0.841 | 0.169 | -2 | 0.734 |
GRK7 |
0.841 | 0.139 | 1 | 0.798 |
PKCD |
0.841 | 0.074 | 2 | 0.806 |
MST4 |
0.841 | 0.020 | 2 | 0.838 |
CLK1 |
0.841 | 0.194 | -3 | 0.730 |
RIPK3 |
0.841 | -0.024 | 3 | 0.728 |
NUAK2 |
0.841 | 0.012 | -3 | 0.814 |
PRKX |
0.840 | 0.188 | -3 | 0.651 |
WNK1 |
0.840 | -0.001 | -2 | 0.835 |
AMPKA1 |
0.839 | 0.039 | -3 | 0.816 |
ACVR2B |
0.839 | 0.201 | -2 | 0.902 |
PDHK1 |
0.839 | -0.212 | 1 | 0.803 |
ACVR2A |
0.839 | 0.190 | -2 | 0.897 |
MARK4 |
0.838 | -0.020 | 4 | 0.888 |
CDK1 |
0.838 | 0.158 | 1 | 0.720 |
MLK1 |
0.838 | -0.090 | 2 | 0.816 |
CAMK2B |
0.838 | 0.084 | 2 | 0.849 |
ALK2 |
0.838 | 0.237 | -2 | 0.915 |
HUNK |
0.838 | -0.094 | 2 | 0.838 |
ULK1 |
0.838 | -0.115 | -3 | 0.801 |
PKN2 |
0.838 | 0.008 | -3 | 0.802 |
PLK1 |
0.837 | 0.068 | -2 | 0.875 |
MAPKAPK2 |
0.837 | 0.073 | -3 | 0.699 |
MSK2 |
0.837 | 0.066 | -3 | 0.721 |
GRK4 |
0.837 | -0.052 | -2 | 0.856 |
HIPK1 |
0.836 | 0.206 | 1 | 0.787 |
HIPK2 |
0.836 | 0.191 | 1 | 0.699 |
MSK1 |
0.836 | 0.121 | -3 | 0.721 |
CAMK2D |
0.835 | -0.021 | -3 | 0.817 |
CDK5 |
0.834 | 0.148 | 1 | 0.751 |
ANKRD3 |
0.834 | -0.048 | 1 | 0.791 |
AURB |
0.834 | 0.133 | -2 | 0.716 |
ATM |
0.834 | -0.014 | 1 | 0.686 |
CDK8 |
0.834 | 0.084 | 1 | 0.724 |
TSSK2 |
0.833 | 0.004 | -5 | 0.754 |
BMPR1A |
0.833 | 0.227 | 1 | 0.739 |
MAPKAPK3 |
0.833 | -0.011 | -3 | 0.747 |
AMPKA2 |
0.833 | 0.030 | -3 | 0.785 |
PAK1 |
0.832 | 0.059 | -2 | 0.784 |
CDK18 |
0.832 | 0.148 | 1 | 0.688 |
BCKDK |
0.832 | -0.133 | -1 | 0.805 |
CAMK2A |
0.832 | 0.048 | 2 | 0.842 |
PKG2 |
0.831 | 0.125 | -2 | 0.723 |
TSSK1 |
0.831 | 0.019 | -3 | 0.833 |
WNK3 |
0.831 | -0.169 | 1 | 0.747 |
MYLK4 |
0.831 | 0.088 | -2 | 0.801 |
DLK |
0.831 | -0.160 | 1 | 0.783 |
JNK3 |
0.830 | 0.146 | 1 | 0.731 |
MASTL |
0.830 | -0.260 | -2 | 0.796 |
NEK9 |
0.830 | -0.129 | 2 | 0.842 |
JNK2 |
0.830 | 0.161 | 1 | 0.695 |
IRE2 |
0.830 | 0.024 | 2 | 0.769 |
PIM2 |
0.830 | 0.118 | -3 | 0.729 |
AKT2 |
0.830 | 0.111 | -3 | 0.678 |
PKCB |
0.829 | 0.021 | 2 | 0.744 |
PAK3 |
0.829 | 0.026 | -2 | 0.778 |
CDK7 |
0.829 | 0.085 | 1 | 0.734 |
CDK19 |
0.829 | 0.087 | 1 | 0.691 |
PKR |
0.828 | 0.005 | 1 | 0.788 |
IRE1 |
0.828 | -0.054 | 1 | 0.727 |
CDK13 |
0.828 | 0.109 | 1 | 0.717 |
CAMK4 |
0.828 | -0.049 | -3 | 0.788 |
PRKD3 |
0.828 | 0.037 | -3 | 0.731 |
AURA |
0.828 | 0.101 | -2 | 0.703 |
DYRK4 |
0.828 | 0.179 | 1 | 0.712 |
CDK17 |
0.827 | 0.135 | 1 | 0.652 |
MNK2 |
0.827 | 0.040 | -2 | 0.810 |
DYRK1B |
0.826 | 0.175 | 1 | 0.733 |
DYRK1A |
0.826 | 0.134 | 1 | 0.778 |
PKCG |
0.826 | -0.003 | 2 | 0.739 |
NIM1 |
0.826 | -0.093 | 3 | 0.747 |
QSK |
0.826 | 0.000 | 4 | 0.866 |
P38G |
0.826 | 0.145 | 1 | 0.642 |
P38B |
0.826 | 0.135 | 1 | 0.733 |
CDK2 |
0.826 | 0.066 | 1 | 0.804 |
DYRK3 |
0.826 | 0.187 | 1 | 0.785 |
PLK3 |
0.825 | -0.011 | 2 | 0.806 |
MNK1 |
0.825 | 0.057 | -2 | 0.821 |
RIPK1 |
0.825 | -0.175 | 1 | 0.742 |
TTBK2 |
0.825 | -0.168 | 2 | 0.715 |
CDK3 |
0.825 | 0.141 | 1 | 0.669 |
SGK3 |
0.825 | 0.080 | -3 | 0.730 |
PKCA |
0.825 | 0.010 | 2 | 0.736 |
MEK1 |
0.825 | -0.129 | 2 | 0.862 |
SIK |
0.825 | -0.001 | -3 | 0.736 |
PAK2 |
0.825 | 0.031 | -2 | 0.773 |
MLK2 |
0.824 | -0.180 | 2 | 0.830 |
PKACA |
0.824 | 0.137 | -2 | 0.690 |
NUAK1 |
0.824 | -0.031 | -3 | 0.766 |
GRK2 |
0.824 | -0.024 | -2 | 0.749 |
MELK |
0.824 | -0.025 | -3 | 0.776 |
MLK3 |
0.823 | -0.084 | 2 | 0.747 |
VRK2 |
0.823 | -0.148 | 1 | 0.838 |
P38A |
0.823 | 0.100 | 1 | 0.767 |
CDK14 |
0.823 | 0.151 | 1 | 0.727 |
MLK4 |
0.823 | -0.063 | 2 | 0.738 |
QIK |
0.823 | -0.076 | -3 | 0.815 |
PKCZ |
0.823 | -0.023 | 2 | 0.783 |
PKCH |
0.823 | -0.011 | 2 | 0.733 |
HIPK3 |
0.822 | 0.143 | 1 | 0.771 |
ERK1 |
0.822 | 0.110 | 1 | 0.707 |
PASK |
0.822 | 0.067 | -3 | 0.818 |
CAMK1G |
0.822 | 0.019 | -3 | 0.748 |
TLK2 |
0.821 | -0.040 | 1 | 0.723 |
CHAK1 |
0.821 | -0.108 | 2 | 0.753 |
BRSK1 |
0.821 | -0.024 | -3 | 0.764 |
ERK2 |
0.821 | 0.092 | 1 | 0.741 |
BRAF |
0.821 | -0.011 | -4 | 0.773 |
DCAMKL1 |
0.821 | 0.037 | -3 | 0.752 |
CDK12 |
0.821 | 0.105 | 1 | 0.694 |
YSK4 |
0.820 | -0.136 | 1 | 0.711 |
CDK16 |
0.820 | 0.150 | 1 | 0.672 |
PAK6 |
0.820 | 0.068 | -2 | 0.708 |
CDK10 |
0.820 | 0.171 | 1 | 0.710 |
CDK9 |
0.820 | 0.080 | 1 | 0.720 |
MARK2 |
0.819 | -0.024 | 4 | 0.797 |
PERK |
0.819 | -0.032 | -2 | 0.893 |
PHKG1 |
0.819 | -0.063 | -3 | 0.790 |
MARK3 |
0.818 | -0.020 | 4 | 0.821 |
PRP4 |
0.818 | 0.044 | -3 | 0.710 |
DAPK3 |
0.818 | 0.126 | -3 | 0.773 |
NEK2 |
0.818 | -0.104 | 2 | 0.806 |
SMMLCK |
0.817 | 0.058 | -3 | 0.798 |
AKT1 |
0.817 | 0.108 | -3 | 0.689 |
PLK4 |
0.816 | -0.088 | 2 | 0.669 |
BRSK2 |
0.816 | -0.076 | -3 | 0.788 |
NEK5 |
0.816 | -0.033 | 1 | 0.752 |
CHK1 |
0.815 | -0.063 | -3 | 0.781 |
CK1E |
0.815 | -0.025 | -3 | 0.516 |
DNAPK |
0.815 | -0.044 | 1 | 0.610 |
PINK1 |
0.814 | -0.087 | 1 | 0.806 |
MEKK3 |
0.814 | -0.122 | 1 | 0.744 |
TLK1 |
0.814 | -0.041 | -2 | 0.901 |
MEKK1 |
0.814 | -0.118 | 1 | 0.751 |
HRI |
0.814 | -0.100 | -2 | 0.890 |
MARK1 |
0.814 | -0.046 | 4 | 0.847 |
P70S6K |
0.814 | 0.030 | -3 | 0.691 |
SSTK |
0.813 | 0.020 | 4 | 0.869 |
P38D |
0.813 | 0.141 | 1 | 0.631 |
TAO3 |
0.813 | -0.031 | 1 | 0.740 |
CAMK1D |
0.813 | 0.049 | -3 | 0.679 |
GRK3 |
0.813 | -0.014 | -2 | 0.723 |
ZAK |
0.812 | -0.126 | 1 | 0.722 |
SMG1 |
0.812 | -0.128 | 1 | 0.700 |
SNRK |
0.812 | -0.170 | 2 | 0.696 |
MAPKAPK5 |
0.812 | -0.098 | -3 | 0.705 |
PKCT |
0.812 | 0.002 | 2 | 0.746 |
GAK |
0.812 | 0.060 | 1 | 0.807 |
MEK5 |
0.811 | -0.225 | 2 | 0.837 |
DRAK1 |
0.811 | -0.122 | 1 | 0.691 |
MEKK2 |
0.811 | -0.110 | 2 | 0.821 |
DAPK1 |
0.810 | 0.098 | -3 | 0.760 |
GSK3A |
0.810 | 0.053 | 4 | 0.499 |
DCAMKL2 |
0.810 | -0.029 | -3 | 0.786 |
CK1D |
0.810 | -0.006 | -3 | 0.466 |
MAK |
0.810 | 0.152 | -2 | 0.673 |
MST3 |
0.809 | -0.050 | 2 | 0.814 |
SGK1 |
0.808 | 0.111 | -3 | 0.596 |
AKT3 |
0.808 | 0.116 | -3 | 0.613 |
WNK4 |
0.808 | -0.116 | -2 | 0.816 |
MRCKA |
0.807 | 0.128 | -3 | 0.727 |
JNK1 |
0.807 | 0.101 | 1 | 0.704 |
IRAK4 |
0.807 | -0.103 | 1 | 0.725 |
CK1A2 |
0.807 | -0.014 | -3 | 0.468 |
CK2A2 |
0.806 | 0.022 | 1 | 0.689 |
ROCK2 |
0.806 | 0.139 | -3 | 0.751 |
CDK6 |
0.805 | 0.126 | 1 | 0.696 |
NEK8 |
0.805 | -0.116 | 2 | 0.815 |
MRCKB |
0.805 | 0.120 | -3 | 0.715 |
GSK3B |
0.805 | 0.001 | 4 | 0.492 |
PAK5 |
0.805 | 0.045 | -2 | 0.666 |
MOK |
0.805 | 0.162 | 1 | 0.799 |
PKCI |
0.804 | -0.013 | 2 | 0.744 |
PKCE |
0.804 | 0.037 | 2 | 0.720 |
MPSK1 |
0.804 | -0.032 | 1 | 0.743 |
MST2 |
0.804 | -0.044 | 1 | 0.754 |
CDK4 |
0.804 | 0.128 | 1 | 0.691 |
CK1G1 |
0.804 | -0.063 | -3 | 0.503 |
EEF2K |
0.804 | 0.026 | 3 | 0.813 |
PAK4 |
0.803 | 0.055 | -2 | 0.682 |
TAO2 |
0.802 | -0.086 | 2 | 0.857 |
PLK2 |
0.802 | 0.017 | -3 | 0.779 |
PHKG2 |
0.802 | -0.060 | -3 | 0.770 |
GCK |
0.802 | -0.039 | 1 | 0.741 |
DMPK1 |
0.801 | 0.165 | -3 | 0.735 |
CAMKK1 |
0.801 | -0.184 | -2 | 0.718 |
ERK7 |
0.800 | 0.014 | 2 | 0.525 |
PDK1 |
0.800 | -0.106 | 1 | 0.733 |
NEK11 |
0.800 | -0.196 | 1 | 0.729 |
CAMKK2 |
0.799 | -0.155 | -2 | 0.718 |
LKB1 |
0.799 | -0.127 | -3 | 0.817 |
TNIK |
0.799 | -0.012 | 3 | 0.847 |
TTK |
0.798 | 0.130 | -2 | 0.908 |
CHK2 |
0.797 | 0.019 | -3 | 0.624 |
TTBK1 |
0.796 | -0.190 | 2 | 0.635 |
NEK4 |
0.796 | -0.127 | 1 | 0.722 |
CAMK1A |
0.796 | 0.026 | -3 | 0.638 |
LRRK2 |
0.795 | -0.136 | 2 | 0.845 |
MINK |
0.795 | -0.074 | 1 | 0.725 |
HGK |
0.795 | -0.068 | 3 | 0.844 |
CK2A1 |
0.795 | -0.001 | 1 | 0.666 |
IRAK1 |
0.795 | -0.256 | -1 | 0.715 |
ROCK1 |
0.794 | 0.125 | -3 | 0.723 |
HPK1 |
0.794 | -0.047 | 1 | 0.730 |
PDHK3_TYR |
0.794 | 0.187 | 4 | 0.937 |
MST1 |
0.793 | -0.087 | 1 | 0.737 |
KHS2 |
0.793 | 0.036 | 1 | 0.736 |
NEK1 |
0.793 | -0.079 | 1 | 0.733 |
LOK |
0.793 | -0.067 | -2 | 0.759 |
TAK1 |
0.792 | -0.130 | 1 | 0.742 |
SLK |
0.792 | -0.079 | -2 | 0.713 |
MEKK6 |
0.792 | -0.159 | 1 | 0.725 |
STK33 |
0.791 | -0.124 | 2 | 0.636 |
KHS1 |
0.791 | -0.014 | 1 | 0.727 |
PKN1 |
0.791 | -0.034 | -3 | 0.711 |
VRK1 |
0.791 | -0.169 | 2 | 0.856 |
SBK |
0.790 | 0.047 | -3 | 0.567 |
MAP3K15 |
0.790 | -0.179 | 1 | 0.699 |
PBK |
0.790 | 0.001 | 1 | 0.724 |
PKG1 |
0.789 | 0.058 | -2 | 0.652 |
PDHK4_TYR |
0.787 | 0.094 | 2 | 0.889 |
CRIK |
0.787 | 0.085 | -3 | 0.684 |
MAP2K6_TYR |
0.786 | 0.067 | -1 | 0.867 |
OSR1 |
0.786 | -0.039 | 2 | 0.812 |
MEK2 |
0.785 | -0.223 | 2 | 0.830 |
BUB1 |
0.785 | 0.006 | -5 | 0.730 |
BMPR2_TYR |
0.785 | 0.072 | -1 | 0.867 |
MAP2K4_TYR |
0.784 | -0.002 | -1 | 0.853 |
EPHA6 |
0.783 | 0.139 | -1 | 0.859 |
TESK1_TYR |
0.783 | -0.027 | 3 | 0.824 |
PDHK1_TYR |
0.781 | -0.008 | -1 | 0.881 |
PKMYT1_TYR |
0.780 | -0.053 | 3 | 0.796 |
YSK1 |
0.780 | -0.147 | 2 | 0.801 |
RIPK2 |
0.780 | -0.263 | 1 | 0.668 |
ALPHAK3 |
0.779 | -0.030 | -1 | 0.761 |
MAP2K7_TYR |
0.779 | -0.159 | 2 | 0.872 |
BIKE |
0.779 | 0.025 | 1 | 0.701 |
EPHB4 |
0.779 | 0.080 | -1 | 0.836 |
PINK1_TYR |
0.778 | -0.079 | 1 | 0.804 |
LIMK2_TYR |
0.778 | 0.013 | -3 | 0.856 |
HASPIN |
0.776 | -0.052 | -1 | 0.656 |
RET |
0.776 | -0.028 | 1 | 0.766 |
NEK3 |
0.776 | -0.163 | 1 | 0.681 |
TXK |
0.776 | 0.116 | 1 | 0.796 |
YES1 |
0.774 | 0.043 | -1 | 0.814 |
ABL2 |
0.773 | 0.050 | -1 | 0.782 |
INSRR |
0.773 | 0.035 | 3 | 0.720 |
BLK |
0.773 | 0.154 | -1 | 0.818 |
ROS1 |
0.772 | -0.036 | 3 | 0.752 |
MST1R |
0.772 | -0.056 | 3 | 0.788 |
MYO3B |
0.772 | -0.087 | 2 | 0.809 |
TYRO3 |
0.771 | -0.067 | 3 | 0.772 |
CK1A |
0.771 | -0.049 | -3 | 0.376 |
CSF1R |
0.771 | -0.027 | 3 | 0.778 |
EPHA4 |
0.771 | 0.041 | 2 | 0.802 |
DDR1 |
0.771 | -0.038 | 4 | 0.877 |
YANK3 |
0.771 | -0.081 | 2 | 0.421 |
LCK |
0.770 | 0.097 | -1 | 0.817 |
FGFR2 |
0.770 | 0.022 | 3 | 0.763 |
FGR |
0.770 | -0.034 | 1 | 0.827 |
LIMK1_TYR |
0.770 | -0.150 | 2 | 0.865 |
FER |
0.769 | -0.040 | 1 | 0.849 |
EPHB2 |
0.769 | 0.066 | -1 | 0.816 |
TYK2 |
0.769 | -0.125 | 1 | 0.761 |
MYO3A |
0.769 | -0.120 | 1 | 0.728 |
KDR |
0.769 | 0.023 | 3 | 0.752 |
EPHB1 |
0.768 | 0.024 | 1 | 0.812 |
JAK3 |
0.768 | -0.042 | 1 | 0.726 |
SRMS |
0.767 | 0.015 | 1 | 0.830 |
ASK1 |
0.767 | -0.211 | 1 | 0.694 |
JAK2 |
0.767 | -0.110 | 1 | 0.754 |
EPHB3 |
0.767 | 0.026 | -1 | 0.820 |
TAO1 |
0.767 | -0.133 | 1 | 0.656 |
ABL1 |
0.766 | -0.008 | -1 | 0.766 |
HCK |
0.766 | 0.007 | -1 | 0.808 |
ITK |
0.766 | -0.005 | -1 | 0.775 |
TNK2 |
0.766 | 0.006 | 3 | 0.746 |
MET |
0.765 | 0.007 | 3 | 0.765 |
KIT |
0.765 | -0.045 | 3 | 0.775 |
FYN |
0.765 | 0.106 | -1 | 0.801 |
TEK |
0.764 | -0.034 | 3 | 0.711 |
FLT3 |
0.763 | -0.063 | 3 | 0.781 |
MERTK |
0.763 | 0.005 | 3 | 0.753 |
PDGFRB |
0.763 | -0.096 | 3 | 0.783 |
FGFR1 |
0.763 | -0.053 | 3 | 0.737 |
AAK1 |
0.762 | 0.056 | 1 | 0.606 |
BMX |
0.762 | 0.003 | -1 | 0.708 |
EPHA7 |
0.761 | 0.027 | 2 | 0.808 |
FGFR3 |
0.761 | -0.004 | 3 | 0.739 |
DDR2 |
0.761 | 0.062 | 3 | 0.709 |
STLK3 |
0.760 | -0.192 | 1 | 0.692 |
FLT1 |
0.759 | -0.018 | -1 | 0.835 |
TEC |
0.759 | -0.022 | -1 | 0.702 |
AXL |
0.759 | -0.061 | 3 | 0.756 |
EPHA5 |
0.759 | 0.056 | 2 | 0.800 |
TNK1 |
0.759 | -0.073 | 3 | 0.752 |
ERBB2 |
0.758 | -0.029 | 1 | 0.774 |
FRK |
0.757 | 0.012 | -1 | 0.817 |
EPHA8 |
0.757 | 0.047 | -1 | 0.808 |
TNNI3K_TYR |
0.757 | -0.050 | 1 | 0.779 |
LTK |
0.756 | -0.067 | 3 | 0.708 |
EPHA3 |
0.755 | -0.062 | 2 | 0.779 |
NTRK1 |
0.755 | -0.101 | -1 | 0.812 |
EPHA1 |
0.755 | -0.023 | 3 | 0.764 |
ALK |
0.755 | -0.103 | 3 | 0.688 |
CK1G3 |
0.755 | -0.039 | -3 | 0.332 |
PTK2 |
0.754 | 0.086 | -1 | 0.804 |
SYK |
0.754 | 0.108 | -1 | 0.792 |
EGFR |
0.754 | 0.053 | 1 | 0.715 |
JAK1 |
0.754 | -0.085 | 1 | 0.683 |
FLT4 |
0.752 | -0.099 | 3 | 0.725 |
WEE1_TYR |
0.752 | -0.081 | -1 | 0.733 |
INSR |
0.752 | -0.101 | 3 | 0.701 |
LYN |
0.752 | -0.039 | 3 | 0.689 |
PDGFRA |
0.751 | -0.204 | 3 | 0.781 |
BTK |
0.751 | -0.151 | -1 | 0.734 |
NEK10_TYR |
0.751 | -0.153 | 1 | 0.608 |
NTRK3 |
0.751 | -0.067 | -1 | 0.770 |
SRC |
0.751 | -0.002 | -1 | 0.781 |
NTRK2 |
0.750 | -0.128 | 3 | 0.724 |
PTK2B |
0.750 | -0.039 | -1 | 0.734 |
MATK |
0.750 | -0.075 | -1 | 0.714 |
ERBB4 |
0.749 | 0.088 | 1 | 0.755 |
EPHA2 |
0.748 | 0.039 | -1 | 0.782 |
FGFR4 |
0.747 | -0.027 | -1 | 0.752 |
CK1G2 |
0.747 | -0.008 | -3 | 0.423 |
PTK6 |
0.746 | -0.219 | -1 | 0.691 |
MUSK |
0.741 | -0.022 | 1 | 0.704 |
IGF1R |
0.741 | -0.085 | 3 | 0.631 |
YANK2 |
0.738 | -0.111 | 2 | 0.445 |
CSK |
0.738 | -0.155 | 2 | 0.805 |
ZAP70 |
0.737 | 0.071 | -1 | 0.715 |
FES |
0.720 | -0.146 | -1 | 0.675 |