Motif 74 (n=231)

Position-wise Probabilities

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uniprot genes site source protein function
A1L390 PLEKHG3 S962 ochoa Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
A2RRP1 NBAS S1384 ochoa NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}.
A4D1S0 KLRG2 S95 ochoa Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) None
A4UGR9 XIRP2 S3059 ochoa Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}.
A5PL33 KRBA1 S355 ochoa Protein KRBA1 None
A7KAX9 ARHGAP32 S1234 ochoa Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.
A8K0Z3 WASHC1 S345 ochoa WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}.
A8MWX3 WASH4P S358 ochoa Putative WAS protein family homolog 4 (Protein FAM39CP) May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}.
A8MYZ6 FOXO6 S275 ochoa Forkhead box protein O6 Transcriptional activator. {ECO:0000250}.
C4AMC7 WASH3P S343 ochoa Putative WAS protein family homolog 3 (Protein FAM39DP) Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}.
D6RIA3 C4orf54 S895 ochoa Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) None
J3KQ70 INO80B-WBP1 S97 ochoa HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) None
K7ELQ4 ATF7-NPFF S304 ochoa ATF7-NPFF readthrough None
K7EQG2 None S125 ochoa Uncharacterized protein None
O00512 BCL9 S62 ochoa B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}.
O14613 CDC42EP2 S31 ochoa Cdc42 effector protein 2 (Binder of Rho GTPases 1) Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.
O14613 CDC42EP2 S141 ochoa Cdc42 effector protein 2 (Binder of Rho GTPases 1) Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.
O15211 RGL2 S409 ochoa Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.
O43379 WDR62 S1123 ochoa WD repeat-containing protein 62 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O60336 MAPKBP1 S1216 ochoa Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.
O75385 ULK1 S588 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75807 PPP1R15A S143 ochoa Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog) Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Also acts a viral restriction factor by attenuating HIV-1 replication (PubMed:31778897). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897). {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:26095357, ECO:0000269|PubMed:31778897, ECO:0000269|PubMed:8139541}.; FUNCTION: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR. {ECO:0000269|PubMed:34985336}.
O75969 AKAP3 S636 ochoa A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) Structural component of sperm fibrous sheath (By similarity). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:35228300). {ECO:0000250|UniProtKB:O88987, ECO:0000269|PubMed:35228300}.
O94850 DDN S508 ochoa Dendrin Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). {ECO:0000250}.
O95602 POLR1A S1695 ochoa DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). {ECO:0000250|UniProtKB:P10964, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.
O95613 PCNT S3242 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
O95754 SEMA4F S718 ochoa Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W) Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity). {ECO:0000250|UniProtKB:Q9Z123, ECO:0000250|UniProtKB:Q9Z143}.
P08151 GLI1 S937 ochoa Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
P10070 GLI2 S1194 ochoa Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}.
P10275 AR S258 psp Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
P12109 COL6A1 S766 ochoa Collagen alpha-1(VI) chain Collagen VI acts as a cell-binding protein.
P15923 TCF3 S139 ochoa|psp Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}.
P16885 PLCG2 S443 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}.
P17947 SPI1 S140 psp Transcription factor PU.1 (31 kDa-transforming protein) Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:23658224, ECO:0000269|PubMed:33951726}.
P19419 ELK1 S324 ochoa|psp ETS domain-containing protein Elk-1 Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}.
P20719 HOXA5 S95 ochoa Homeobox protein Hox-A5 (Homeobox protein Hox-1C) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
P21580 TNFAIP3 S466 ochoa Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269|PubMed:14748687, ECO:0000269|PubMed:15258597, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17961127, ECO:0000269|PubMed:18164316, ECO:0000269|PubMed:18952128, ECO:0000269|PubMed:19494296, ECO:0000269|PubMed:22099304, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:8692885, ECO:0000269|PubMed:9299557, ECO:0000269|PubMed:9882303}.
P22736 NR4A1 S140 psp Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}.
P27815 PDE4A S628 ochoa 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.
P35555 FBN1 S2711 ochoa Fibrillin-1 [Cleaved into: Asprosin] [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:15062093, PubMed:1860873). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15062093, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:1860873, ECO:0000269|PubMed:24039232, ECO:0000303|PubMed:27026396}.; FUNCTION: [Asprosin]: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:27087445, ECO:0000269|PubMed:30853600, ECO:0000269|PubMed:31230984}.
P35568 IRS1 S547 ochoa Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P40926 MDH2 S47 ochoa Malate dehydrogenase, mitochondrial (EC 1.1.1.37) None
P48551 IFNAR2 S400 ochoa|psp Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2) Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:10556041, PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT) (PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:12105218, PubMed:28165510, PubMed:9121453). {ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:10556041, ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:17517919, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059, ECO:0000269|PubMed:8798579, ECO:0000269|PubMed:8969169, ECO:0000269|PubMed:9121453}.; FUNCTION: [Isoform 3]: Potent inhibitor of type I IFN receptor activity. {ECO:0000269|PubMed:7759950}.
P49810 PSEN2 S25 ochoa Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}.
P50219 MNX1 S79 ochoa Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). {ECO:0000250|UniProtKB:Q9QZW9}.
P51449 RORC S205 psp Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:20203100, PubMed:22789990, PubMed:26160376). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:20203100, PubMed:22789990, PubMed:26160376). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376). {ECO:0000250|UniProtKB:P51450, ECO:0000269|PubMed:19381306, ECO:0000269|PubMed:19965867, ECO:0000269|PubMed:20203100, ECO:0000269|PubMed:22789990, ECO:0000269|PubMed:26160376}.; FUNCTION: [Isoform 2]: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus. {ECO:0000269|PubMed:21499262}.
P51532 SMARCA4 S122 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51532 SMARCA4 S132 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51608 MECP2 S216 ochoa|psp Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.
P52701 MSH6 S137 ochoa DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}.
P53816 PLAAT3 S85 ochoa Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65) Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760, PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19047760, PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19047760, PubMed:19615464, PubMed:22605381, PubMed:22825852). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity). {ECO:0000250|UniProtKB:Q8R3U1, ECO:0000269|PubMed:19047760, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:22923616, ECO:0000303|PubMed:26503625}.; FUNCTION: (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878). {ECO:0000269|PubMed:28077878}.
P54259 ATN1 S677 ochoa Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
P54750 PDE1A S403 ochoa Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. {ECO:0000269|PubMed:8557689}.
P56177 DLX1 S209 ochoa Homeobox protein DLX-1 Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). {ECO:0000250|UniProtKB:Q64317, ECO:0000269|PubMed:14671321}.
P56524 HDAC4 S215 ochoa Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P57721 PCBP3 S201 ochoa Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.
P67809 YBX1 S209 ochoa|psp Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}.
P78559 MAP1A S909 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P78559 MAP1A S2617 ochoa|psp Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q02548 PAX5 S283 ochoa Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP) Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269|PubMed:10811620, ECO:0000269|PubMed:27181361, ECO:0000269|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269|PubMed:23678172, ECO:0000269|PubMed:31941781}.
Q05639 EEF1A2 S205 psp Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}.
Q07343 PDE4B S601 ochoa 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}.
Q08211 DHX9 S87 ochoa ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}.
Q08499 PDE4D S657 ochoa 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}.
Q12955 ANK3 S1702 ochoa Ankyrin-3 (ANK-3) (Ankyrin-G) Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.
Q13029 PRDM2 S912 ochoa PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}.
Q13029 PRDM2 S914 ochoa PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}.
Q13191 CBLB S672 ochoa E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.
Q13207 TBX2 S657 ochoa T-box transcription factor TBX2 (T-box protein 2) Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}.
Q13285 NR5A1 S203 psp Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250|UniProtKB:P33242, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:27378692, ECO:0000269|PubMed:28459839}.
Q13435 SF3B2 S655 ochoa Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}.
Q13485 SMAD4 S343 psp Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:9389648}.
Q13888 GTF2H2 S237 ochoa General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit) Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11319235, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:8194529, ECO:0000269|PubMed:9852112}.
Q14123 PDE1C S413 ochoa Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3) Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). {ECO:0000269|PubMed:29860631, ECO:0000269|PubMed:8557689, ECO:0000305|PubMed:29860631}.
Q14541 HNF4G S121 ochoa Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2) Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
Q14814 MEF2D S192 ochoa|psp Myocyte-specific enhancer factor 2D Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.
Q15699 ALX1 S69 ochoa ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}.
Q15742 NAB2 S159 ochoa NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.
Q16763 UBE2S S73 ochoa Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}.
Q16799 RTN1 S487 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q18PE1 DOK7 S419 ochoa Protein Dok-7 (Downstream of tyrosine kinase 7) Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}.
Q24JP5 TMEM132A S913 ochoa Transmembrane protein 132A (HSPA5-binding protein 1) May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). {ECO:0000250}.
Q3MII6 TBC1D25 S130 ochoa TBC1 domain family member 25 Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}.
Q4VCS5 AMOT S842 ochoa Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q53EP0 FNDC3B S208 ochoa Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.
Q53ET0 CRTC2 S624 ochoa CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.
Q53HL2 CDCA8 S219 ochoa|psp Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}.
Q562E7 WDR81 S1272 ochoa WD repeat-containing protein 81 Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}.
Q5BKX5 ACTMAP S316 ochoa Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}.
Q5JST6 EFHC2 S382 ochoa EF-hand domain-containing family member C2 Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. {ECO:0000269|PubMed:36191189}.
Q5JSZ5 PRRC2B S740 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5JSZ5 PRRC2B S853 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5JUX0 SPIN3 S195 ochoa Spindlin-3 (Spindlin-like protein 3) (SPIN-3) Exhibits H3K4me3-binding activity. {ECO:0000269|PubMed:29061846}.
Q5T0Z8 C6orf132 S1011 ochoa Uncharacterized protein C6orf132 None
Q5T1V6 DDX59 S64 ochoa Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) None
Q5T5P2 KIAA1217 S1794 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5TZA2 CROCC S494 ochoa Rootletin (Ciliary rootlet coiled-coil protein) Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.
Q5UIP0 RIF1 S782 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VSL9 STRIP1 S335 ochoa Striatin-interacting protein 1 (Protein FAM40A) Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}.
Q5VT06 CEP350 S2830 ochoa Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}.
Q5VUA4 ZNF318 S2243 ochoa Zinc finger protein 318 (Endocrine regulatory protein) [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.
Q63HK3 ZKSCAN2 S591 ochoa Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694) May be involved in transcriptional regulation.
Q68EM7 ARHGAP17 S575 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q69YH5 CDCA2 S726 ochoa Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Q6AI08 HEATR6 S1124 ochoa HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) Amplification-dependent oncogene.
Q6GQQ9 OTUD7B S449 ochoa OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}.
Q6JBY9 RCSD1 S351 ochoa CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.
Q6N022 TENM4 S212 ochoa Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}.
Q6P1K8 GTF2H2C; S237 ochoa General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein) Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. {ECO:0000250}.
Q6PJT7 ZC3H14 S527 ochoa Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}.
Q6VEQ5 WASH2P S345 ochoa WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}.
Q6ZN17 LIN28B S203 ochoa Protein lin-28 homolog B (Lin-28B) Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000250|UniProtKB:Q45KJ6, ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22118463}.
Q6ZNC4 ZNF704 S97 ochoa Zinc finger protein 704 Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}.
Q6ZTU2 EP400P1 S129 ochoa Putative EP400-like protein (EP400 pseudogene 1) None
Q70CQ3 USP30 S210 ochoa Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}.
Q711Q0 CEFIP S116 ochoa Cardiac-enriched FHL2-interacting protein Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}.
Q7Z2Z1 TICRR S1623 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z2Z1 TICRR S1750 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z3K3 POGZ S292 ochoa Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.
Q7Z591 AKNA S1377 ochoa Microtubule organization protein AKNA (AT-hook-containing transcription factor) Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
Q7Z5J4 RAI1 S106 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q7Z6M1 RABEPK S133 ochoa Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) Rab9 effector required for endosome to trans-Golgi network (TGN) transport. {ECO:0000269|PubMed:9230071}.
Q7Z7B0 FILIP1 S979 ochoa Filamin-A-interacting protein 1 (FILIP) By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}.
Q86UU0 BCL9L S750 ochoa B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86YS6 RAB43 S193 ochoa Ras-related protein Rab-43 (Ras-related protein Rab-41) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057, ECO:0000269|PubMed:18664496, ECO:0000269|PubMed:21255211}.
Q8IWE5 PLEKHM2 S559 ochoa Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}.
Q8IX21 SLF2 S568 ochoa SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.
Q8IXF0 NPAS3 S748 ochoa Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}.
Q8IY33 MICALL2 S318 ochoa MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}.
Q8IY81 FTSJ3 S584 ochoa pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}.
Q8IYB5 SMAP1 S207 ochoa Stromal membrane-associated protein 1 GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). {ECO:0000250}.
Q8IYL2 TRMT44 S533 ochoa Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. {ECO:0000250}.
Q8IYW5 RNF168 S481 ochoa E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}.
Q8IZD0 SAMD14 S117 ochoa Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) None
Q8IZP0 ABI1 S267 psp Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Q8N163 CCAR2 S124 ochoa Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}.
Q8N1G1 REXO1 S358 ochoa RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}.
Q8N1G1 REXO1 S794 ochoa RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}.
Q8N264 ARHGAP24 S415 ochoa|psp Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
Q8N2S1 LTBP4 S300 ochoa Latent-transforming growth factor beta-binding protein 4 (LTBP-4) Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. {ECO:0000250|UniProtKB:Q14766}.
Q8N3D4 EHBP1L1 S1168 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8N3K9 CMYA5 S767 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8N3V7 SYNPO S501 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8ND56 LSM14A S124 ochoa Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}.
Q8NFU0 BEST4 S397 ochoa Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 2) Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by Calcium (Ca2+) (PubMed:12907679, PubMed:18400985). Mediates the movement of hydrogencarbonate and chloride (PubMed:12907679, PubMed:18400985). {ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}.
Q8TBB5 KLHDC4 S114 ochoa Kelch domain-containing protein 4 None
Q8TEW0 PARD3 S1335 ochoa Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
Q8WUJ0 STYX S184 ochoa Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein) Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q60969, ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}.
Q8WW38 ZFPM2 S904 ochoa Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2) Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}.
Q93052 LPP S231 ochoa Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.
Q96B70 LENG9 S440 ochoa Leukocyte receptor cluster member 9 None
Q96CA5 BIRC7 S37 ochoa Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed:11084335, PubMed:11162435, PubMed:11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed:11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed:11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed:11024045). {ECO:0000269|PubMed:11024045, ECO:0000269|PubMed:11084335, ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11865055, ECO:0000269|PubMed:16729033, ECO:0000269|PubMed:17294084}.; FUNCTION: [Isoform 1]: Blocks staurosporine-induced apoptosis (PubMed:11322947). Promotes natural killer (NK) cell-mediated killing (PubMed:18034418). {ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}.; FUNCTION: [Isoform 2]: Blocks etoposide-induced apoptosis (PubMed:11162435, PubMed:11322947). Protects against natural killer (NK) cell-mediated killing (PubMed:18034418). {ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}.
Q96DT6 ATG4C S369 ochoa Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C) Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (PubMed:21177865). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288). In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (PubMed:33773106). {ECO:0000250|UniProtKB:Q9Y4P1, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}.
Q96E14 RMI2 S20 ochoa RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082, ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}.
Q96FX7 TRMT61A S263 ochoa tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}.
Q96IZ5 RBM41 S232 ochoa RNA-binding protein 41 (RNA-binding motif protein 41) May bind RNA. {ECO:0000305}.
Q96JK2 DCAF5 S468 ochoa DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.
Q96JK2 DCAF5 S794 ochoa DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.
Q96JQ0 DCHS1 S2995 ochoa Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}.
Q96KQ7 EHMT2 S140 ochoa Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}.
Q96L91 EP400 S140 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96LJ8 UBXN10 S65 ochoa UBX domain-containing protein 10 (UBX domain-containing protein 3) VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662). {ECO:0000269|PubMed:26389662}.
Q96PK6 RBM14 S291 ochoa RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}.
Q96PN7 TRERF1 S54 ochoa Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.
Q99460 PSMD1 S315 ochoa 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.
Q99865 SPIN2A S195 ochoa Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A) May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000250|UniProtKB:Q9BPZ2, ECO:0000269|PubMed:29061846}.
Q9BPZ2 SPIN2B S195 ochoa Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B) Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846). {ECO:0000269|PubMed:12145692, ECO:0000269|PubMed:29061846}.
Q9BQ39 DDX50 S464 ochoa ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}.
Q9BQI7 PSD2 S191 ochoa PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2) None
Q9BR39 JPH2 S157 ochoa Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}.
Q9BUH8 BEGAIN S502 ochoa Brain-enriched guanylate kinase-associated protein May sustain the structure of the postsynaptic density (PSD).
Q9BXI6 TBC1D10A S383 ochoa TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}.
Q9BYB0 SHANK3 S1577 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BYE2 TMPRSS13 S135 ochoa Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity). {ECO:0000250|UniProtKB:Q5U405, ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451}.
Q9BZI1 IRX2 S297 ochoa Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2) None
Q9C086 INO80B S97 ochoa INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}.
Q9C0B5 ZDHHC5 S554 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0D0 PHACTR1 S237 ochoa Phosphatase and actin regulator 1 Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}.
Q9C0H5 ARHGAP39 S407 ochoa Rho GTPase-activating protein 39 None
Q9H116 GZF1 S265 ochoa GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}.
Q9H1E3 NUCKS1 S214 ochoa Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}.
Q9H211 CDT1 S79 ochoa DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9H706 GAREM1 S742 ochoa GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.
Q9H7Z6 KAT8 S42 ochoa Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}.
Q9HCE5 METTL14 S399 ochoa|psp N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14) The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27281194, PubMed:27373337, PubMed:29348140). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}.
Q9HDC5 JPH1 S157 ochoa Junctophilin-1 (JP-1) (Junctophilin type 1) Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Q9NQA3 WASH6P S327 ochoa WAS protein family homolog 6 (Protein FAM39A) May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}.
Q9NQG7 HPS4 S272 ochoa BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog) Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). {ECO:0000269|PubMed:23084991}.
Q9NQS1 AVEN S261 ochoa Cell death regulator Aven Protects against apoptosis mediated by Apaf-1.
Q9NQU5 PAK6 S616 ochoa Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
Q9NR30 DDX21 S513 ochoa Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}.
Q9NRG9 AAAS S33 ochoa Aladin (Adracalin) Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606). {ECO:0000269|PubMed:11062474, ECO:0000269|PubMed:11159947, ECO:0000269|PubMed:16022285, ECO:0000269|PubMed:26246606}.
Q9NTI5 PDS5B S1283 ochoa Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}.
Q9NUJ3 TCP11L1 S56 ochoa T-complex protein 11-like protein 1 None
Q9NVC3 SLC38A7 S28 ochoa Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation (PubMed:28416685, PubMed:35561222). The transport activity requires an acidic lysosomal lumen (PubMed:28416685). {ECO:0000269|PubMed:28416685, ECO:0000269|PubMed:35561222}.
Q9NW68 BSDC1 S329 ochoa BSD domain-containing protein 1 None
Q9NYA4 MTMR4 S961 ochoa Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}.
Q9NYV4 CDK12 S1083 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9P202 WHRN S685 ochoa Whirlin (Autosomal recessive deafness type 31 protein) Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}.
Q9P206 NHSL3 S979 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9UBN7 HDAC6 S22 ochoa|psp Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}.
Q9UER7 DAXX S702 ochoa Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}.
Q9UGU0 TCF20 S1134 ochoa Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.
Q9UHQ9 CYB5R1 S169 ochoa NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2) NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.
Q9UIW0 VAX2 S53 ochoa Ventral anterior homeobox 2 Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}.
Q9UJF2 RASAL2 S758 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UKI2 CDC42EP3 S32 ochoa Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.
Q9UKK3 PARP4 S1434 ochoa Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q9UKV0 HDAC9 S189 ochoa Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Q9UL54 TAOK2 S825 ochoa Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}.
Q9ULM3 YEATS2 S868 ochoa YEATS domain-containing protein 2 Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.
Q9UN79 SOX13 S310 ochoa Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}.
Q9UNZ2 NSFL1C S114 ochoa NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
Q9UPQ9 TNRC6B S385 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9UQ84 EXO1 S598 ochoa Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.
Q9UQB3 CTNND2 S461 ochoa Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}.
Q9Y242 TCF19 S193 ochoa Transcription factor 19 (TCF-19) (Transcription factor SC1) Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition (PubMed:1868030, PubMed:31141247). May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1 (PubMed:31141247). {ECO:0000269|PubMed:1868030, ECO:0000269|PubMed:31141247}.
Q9Y2I6 NINL S585 ochoa|psp Ninein-like protein Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.
Q9Y2K7 KDM2A S832 ochoa Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.
Q9Y2L6 FRMD4B S992 ochoa FERM domain-containing protein 4B (GRP1-binding protein GRSP1) Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.
Q9Y3A4 RRP7A S99 ochoa Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14) Nucleolar protein that is involved in ribosomal RNA (rRNA) processing (PubMed:33199730). Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development (PubMed:33199730). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:33199730, ECO:0000269|PubMed:34516797}.
Q9Y3Q8 TSC22D4 S370 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y4B5 MTCL1 S87 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y4B5 MTCL1 S306 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y572 RIPK3 S410 ochoa Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}.
Q9Y657 SPIN1 S199 ochoa Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}.
Q9Y6R9 CCDC61 S458 ochoa Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}.
Q9Y6X0 SETBP1 S830 ochoa SET-binding protein (SEB) None
P13798 APEH S97 Sugiyama Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}.
O75676 RPS6KA4 S402 Sugiyama Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.
O60318 MCM3AP S508 SIGNOR Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}.
Download
reactome_id name p -log10_p
R-HSA-8941326 RUNX2 regulates bone development 0.000061 4.216
R-HSA-9022534 Loss of MECP2 binding ability to 5hmC-DNA 0.000456 3.341
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.000275 3.561
R-HSA-9022692 Regulation of MECP2 expression and activity 0.000370 3.431
R-HSA-9006936 Signaling by TGFB family members 0.000479 3.319
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.000637 3.196
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.001222 2.913
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.001509 2.821
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 0.002763 2.559
R-HSA-9022927 MECP2 regulates transcription of genes involved in GABA signaling 0.003939 2.405
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.005307 2.275
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 0.005307 2.275
R-HSA-9017802 Noncanonical activation of NOTCH3 0.006863 2.163
R-HSA-111957 Cam-PDE 1 activation 0.006863 2.163
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.006863 2.163
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.003692 2.433
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.005307 2.275
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.005737 2.241
R-HSA-8878159 Transcriptional regulation by RUNX3 0.006749 2.171
R-HSA-8878166 Transcriptional regulation by RUNX2 0.004720 2.326
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.007708 2.113
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.008537 2.069
R-HSA-9022707 MECP2 regulates transcription factors 0.010511 1.978
R-HSA-383280 Nuclear Receptor transcription pathway 0.010878 1.963
R-HSA-350054 Notch-HLH transcription pathway 0.009416 2.026
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration 0.010511 1.978
R-HSA-9031628 NGF-stimulated transcription 0.011208 1.950
R-HSA-9839373 Signaling by TGFBR3 0.009920 2.004
R-HSA-212436 Generic Transcription Pathway 0.009548 2.020
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 0.010346 1.985
R-HSA-9839394 TGFBR3 expression 0.012361 1.908
R-HSA-525793 Myogenesis 0.013447 1.871
R-HSA-162582 Signal Transduction 0.013720 1.863
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.014838 1.829
R-HSA-9856651 MITF-M-dependent gene expression 0.015580 1.807
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.017241 1.763
R-HSA-180024 DARPP-32 events 0.017021 1.769
R-HSA-8986944 Transcriptional Regulation by MECP2 0.019530 1.709
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.021187 1.674
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.021187 1.674
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.021187 1.674
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.021187 1.674
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.021187 1.674
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.030093 1.522
R-HSA-9673013 Diseases of Telomere Maintenance 0.030093 1.522
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.030093 1.522
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.030093 1.522
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.030093 1.522
R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 0.030093 1.522
R-HSA-9005895 Pervasive developmental disorders 0.025351 1.596
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.025351 1.596
R-HSA-9697154 Disorders of Nervous System Development 0.025351 1.596
R-HSA-5610787 Hedgehog 'off' state 0.028840 1.540
R-HSA-73857 RNA Polymerase II Transcription 0.031410 1.503
R-HSA-74160 Gene expression (Transcription) 0.028858 1.540
R-HSA-9909396 Circadian clock 0.027276 1.564
R-HSA-111885 Opioid Signalling 0.032817 1.484
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.034705 1.460
R-HSA-5632684 Hedgehog 'on' state 0.033980 1.469
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.035324 1.452
R-HSA-201681 TCF dependent signaling in response to WNT 0.037021 1.432
R-HSA-8853884 Transcriptional Regulation by VENTX 0.038071 1.419
R-HSA-3304347 Loss of Function of SMAD4 in Cancer 0.044800 1.349
R-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer 0.044800 1.349
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer 0.044800 1.349
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.087600 1.057
R-HSA-74713 IRS activation 0.101438 0.994
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.141711 0.849
R-HSA-2470946 Cohesin Loading onto Chromatin 0.141711 0.849
R-HSA-112412 SOS-mediated signalling 0.141711 0.849
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.154731 0.810
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.052717 1.278
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.056645 1.247
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.056645 1.247
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.056645 1.247
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.056645 1.247
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.180185 0.744
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 0.180185 0.744
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.192624 0.715
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.082149 1.085
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.086690 1.062
R-HSA-9615710 Late endosomal microautophagy 0.100739 0.997
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.100739 0.997
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.252057 0.599
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.252057 0.599
R-HSA-176412 Phosphorylation of the APC/C 0.263409 0.579
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.263409 0.579
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.307130 0.513
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.172711 0.763
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.317650 0.498
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.317650 0.498
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.328012 0.484
R-HSA-72165 mRNA Splicing - Minor Pathway 0.200092 0.699
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.200092 0.699
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.205631 0.687
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.348266 0.458
R-HSA-8943723 Regulation of PTEN mRNA translation 0.358164 0.446
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.358164 0.446
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.358164 0.446
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.233539 0.632
R-HSA-73772 RNA Polymerase I Promoter Escape 0.233539 0.632
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.239152 0.621
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.239152 0.621
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.239152 0.621
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.250395 0.601
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.256023 0.592
R-HSA-445095 Interaction between L1 and Ankyrins 0.396281 0.402
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.295412 0.530
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.295412 0.530
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.423382 0.373
R-HSA-8854518 AURKA Activation by TPX2 0.312221 0.506
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.351064 0.455
R-HSA-380287 Centrosome maturation 0.362032 0.441
R-HSA-9823730 Formation of definitive endoderm 0.317650 0.498
R-HSA-9609690 HCMV Early Events 0.416652 0.380
R-HSA-72163 mRNA Splicing - Major Pathway 0.409837 0.387
R-HSA-9646399 Aggrephagy 0.161942 0.791
R-HSA-9675151 Disorders of Developmental Biology 0.041568 1.381
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.146038 0.836
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.172711 0.763
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.307974 0.511
R-HSA-72086 mRNA Capping 0.414486 0.382
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.256023 0.592
R-HSA-198203 PI3K/AKT activation 0.180185 0.744
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 0.101438 0.994
R-HSA-73863 RNA Polymerase I Transcription Termination 0.091304 1.040
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.340032 0.468
R-HSA-453276 Regulation of mitotic cell cycle 0.340032 0.468
R-HSA-2467813 Separation of Sister Chromatids 0.303414 0.518
R-HSA-4641265 Repression of WNT target genes 0.216942 0.664
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.121577 0.915
R-HSA-1566948 Elastic fibre formation 0.151303 0.820
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.045175 1.345
R-HSA-5693537 Resolution of D-Loop Structures 0.125398 0.902
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.101438 0.994
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.042103 1.376
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.240529 0.619
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.120356 0.920
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.120356 0.920
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.285603 0.544
R-HSA-73864 RNA Polymerase I Transcription 0.145648 0.837
R-HSA-9692913 SARS-CoV-1-mediated effects on programmed cell death 0.087600 1.057
R-HSA-8951430 RUNX3 regulates WNT signaling 0.141711 0.849
R-HSA-2129379 Molecules associated with elastic fibres 0.110431 0.957
R-HSA-9675126 Diseases of mitotic cell cycle 0.115366 0.938
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.138616 0.858
R-HSA-5658442 Regulation of RAS by GAPs 0.222340 0.653
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.410448 0.387
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.302913 0.519
R-HSA-5693607 Processing of DNA double-strand break ends 0.156409 0.806
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.317806 0.498
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.386969 0.412
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.130490 0.884
R-HSA-9754189 Germ layer formation at gastrulation 0.307130 0.513
R-HSA-5358508 Mismatch Repair 0.048893 1.311
R-HSA-5693538 Homology Directed Repair 0.327812 0.484
R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 0.044800 1.349
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 0.115067 0.939
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 0.115067 0.939
R-HSA-428543 Inactivation of CDC42 and RAC1 0.167555 0.776
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.204876 0.689
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.228825 0.640
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.228825 0.640
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.130490 0.884
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.274591 0.561
R-HSA-69052 Switching of origins to a post-replicative state 0.128297 0.892
R-HSA-68949 Orc1 removal from chromatin 0.233539 0.632
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.244771 0.611
R-HSA-68877 Mitotic Prometaphase 0.406423 0.391
R-HSA-9613829 Chaperone Mediated Autophagy 0.048893 1.311
R-HSA-2424491 DAP12 signaling 0.423382 0.373
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.053823 1.269
R-HSA-9686347 Microbial modulation of RIPK1-mediated regulated necrosis 0.141711 0.849
R-HSA-74749 Signal attenuation 0.180185 0.744
R-HSA-8854214 TBC/RABGAPs 0.044196 1.355
R-HSA-5689896 Ovarian tumor domain proteases 0.146038 0.836
R-HSA-3295583 TRP channels 0.386969 0.412
R-HSA-5358351 Signaling by Hedgehog 0.090914 1.041
R-HSA-9603381 Activated NTRK3 signals through PI3K 0.141711 0.849
R-HSA-9693928 Defective RIPK1-mediated regulated necrosis 0.180185 0.744
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.091304 1.040
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.151303 0.820
R-HSA-9690406 Transcriptional regulation of testis differentiation 0.041568 1.381
R-HSA-5693532 DNA Double-Strand Break Repair 0.266224 0.575
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.399836 0.398
R-HSA-9612973 Autophagy 0.129860 0.887
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.289795 0.538
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.205631 0.687
R-HSA-1257604 PIP3 activates AKT signaling 0.350785 0.455
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 0.073550 1.133
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 0.087600 1.057
R-HSA-2562578 TRIF-mediated programmed cell death 0.141711 0.849
R-HSA-9839383 TGFBR3 PTM regulation 0.154731 0.810
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.060671 1.217
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.252057 0.599
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.274591 0.561
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.307130 0.513
R-HSA-1181150 Signaling by NODAL 0.317650 0.498
R-HSA-420029 Tight junction interactions 0.377513 0.423
R-HSA-113418 Formation of the Early Elongation Complex 0.405453 0.392
R-HSA-68962 Activation of the pre-replicative complex 0.423382 0.373
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.423382 0.373
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.410448 0.387
R-HSA-1632852 Macroautophagy 0.096604 1.015
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.211187 0.675
R-HSA-9663891 Selective autophagy 0.062818 1.202
R-HSA-9842663 Signaling by LTK 0.216942 0.664
R-HSA-1502540 Signaling by Activin 0.252057 0.599
R-HSA-9932451 SWI/SNF chromatin remodelers 0.377513 0.423
R-HSA-9932444 ATP-dependent chromatin remodelers 0.377513 0.423
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 0.128490 0.891
R-HSA-8934903 Receptor Mediated Mitophagy 0.180185 0.744
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.135629 0.868
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.285603 0.544
R-HSA-69002 DNA Replication Pre-Initiation 0.282236 0.549
R-HSA-9006925 Intracellular signaling by second messengers 0.192157 0.716
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.048893 1.311
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.338216 0.471
R-HSA-5689603 UCH proteinases 0.367490 0.435
R-HSA-3214847 HATs acetylate histones 0.237331 0.625
R-HSA-6794361 Neurexins and neuroligins 0.233539 0.632
R-HSA-68867 Assembly of the pre-replicative complex 0.209462 0.679
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.334495 0.476
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.289795 0.538
R-HSA-428540 Activation of RAC1 0.204876 0.689
R-HSA-8951936 RUNX3 regulates p14-ARF 0.216942 0.664
R-HSA-418457 cGMP effects 0.240529 0.619
R-HSA-69473 G2/M DNA damage checkpoint 0.131705 0.880
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.358164 0.446
R-HSA-73894 DNA Repair 0.362047 0.441
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.172711 0.763
R-HSA-201451 Signaling by BMP 0.396281 0.402
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.378352 0.422
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.110431 0.957
R-HSA-68886 M Phase 0.419128 0.378
R-HSA-9007101 Rab regulation of trafficking 0.142362 0.847
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.125398 0.902
R-HSA-1482839 Acyl chain remodelling of PE 0.135629 0.868
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.285603 0.544
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.423382 0.373
R-HSA-69278 Cell Cycle, Mitotic 0.408201 0.389
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.125398 0.902
R-HSA-9675135 Diseases of DNA repair 0.050781 1.294
R-HSA-193692 Regulated proteolysis of p75NTR 0.167555 0.776
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 0.167555 0.776
R-HSA-111458 Formation of apoptosome 0.180185 0.744
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.069003 1.161
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.192624 0.715
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.240529 0.619
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.252057 0.599
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.405453 0.392
R-HSA-69242 S Phase 0.249609 0.603
R-HSA-195721 Signaling by WNT 0.116857 0.932
R-HSA-1640170 Cell Cycle 0.227371 0.643
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.396281 0.402
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.069972 1.155
R-HSA-69239 Synthesis of DNA 0.274000 0.562
R-HSA-9768759 Regulation of NPAS4 gene expression 0.285603 0.544
R-HSA-5688426 Deubiquitination 0.130881 0.883
R-HSA-69275 G2/M Transition 0.382436 0.417
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.100739 0.997
R-HSA-453274 Mitotic G2-G2/M phases 0.389303 0.410
R-HSA-69620 Cell Cycle Checkpoints 0.253462 0.596
R-HSA-8878171 Transcriptional regulation by RUNX1 0.085439 1.068
R-HSA-3371556 Cellular response to heat stress 0.340264 0.468
R-HSA-4839726 Chromatin organization 0.230985 0.636
R-HSA-9627069 Regulation of the apoptosome activity 0.180185 0.744
R-HSA-111461 Cytochrome c-mediated apoptotic response 0.204876 0.689
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.240529 0.619
R-HSA-1482922 Acyl chain remodelling of PI 0.317650 0.498
R-HSA-69481 G2/M Checkpoints 0.173924 0.760
R-HSA-2672351 Stimuli-sensing channels 0.278115 0.556
R-HSA-2559583 Cellular Senescence 0.361794 0.442
R-HSA-9664873 Pexophagy 0.180185 0.744
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.328012 0.484
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.377513 0.423
R-HSA-9659379 Sensory processing of sound 0.383754 0.416
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.120356 0.920
R-HSA-6794362 Protein-protein interactions at synapses 0.415720 0.381
R-HSA-4086398 Ca2+ pathway 0.351064 0.455
R-HSA-9692914 SARS-CoV-1-host interactions 0.269891 0.569
R-HSA-157118 Signaling by NOTCH 0.106070 0.974
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.069003 1.161
R-HSA-205043 NRIF signals cell death from the nucleus 0.240529 0.619
R-HSA-9856872 Malate-aspartate shuttle 0.240529 0.619
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.252057 0.599
R-HSA-198753 ERK/MAPK targets 0.328012 0.484
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.386969 0.412
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 0.414486 0.382
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.323381 0.490
R-HSA-427413 NoRC negatively regulates rRNA expression 0.340032 0.468
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.327812 0.484
R-HSA-3247509 Chromatin modifying enzymes 0.195092 0.710
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.118268 0.927
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.048756 1.312
R-HSA-2028269 Signaling by Hippo 0.285603 0.544
R-HSA-9834899 Specification of the neural plate border 0.307130 0.513
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.076131 1.118
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.076131 1.118
R-HSA-166520 Signaling by NTRKs 0.112635 0.948
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.095988 1.018
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.307130 0.513
R-HSA-1482801 Acyl chain remodelling of PS 0.377513 0.423
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.256023 0.592
R-HSA-5689880 Ub-specific processing proteases 0.337695 0.471
R-HSA-421270 Cell-cell junction organization 0.058312 1.234
R-HSA-75893 TNF signaling 0.075880 1.120
R-HSA-418990 Adherens junctions interactions 0.074780 1.126
R-HSA-9006335 Signaling by Erythropoietin 0.414486 0.382
R-HSA-9831926 Nephron development 0.048893 1.311
R-HSA-3214842 HDMs demethylate histones 0.377513 0.423
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.151303 0.820
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.073303 1.135
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.086690 1.062
R-HSA-9683610 Maturation of nucleoprotein 0.228825 0.640
R-HSA-446728 Cell junction organization 0.089029 1.050
R-HSA-2586552 Signaling by Leptin 0.180185 0.744
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.338216 0.471
R-HSA-1980143 Signaling by NOTCH1 0.041003 1.387
R-HSA-212165 Epigenetic regulation of gene expression 0.272408 0.565
R-HSA-9762292 Regulation of CDH11 function 0.180185 0.744
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.135629 0.868
R-HSA-5687128 MAPK6/MAPK4 signaling 0.055562 1.255
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.233539 0.632
R-HSA-9013694 Signaling by NOTCH4 0.356556 0.448
R-HSA-69206 G1/S Transition 0.360978 0.443
R-HSA-3858494 Beta-catenin independent WNT signaling 0.414259 0.383
R-HSA-5357905 Regulation of TNFR1 signaling 0.050781 1.294
R-HSA-1500931 Cell-Cell communication 0.145449 0.837
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.278546 0.555
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.420968 0.376
R-HSA-9730414 MITF-M-regulated melanocyte development 0.068540 1.164
R-HSA-111933 Calmodulin induced events 0.140812 0.851
R-HSA-210745 Regulation of gene expression in beta cells 0.100739 0.997
R-HSA-111997 CaM pathway 0.140812 0.851
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.296449 0.528
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.389136 0.410
R-HSA-9012852 Signaling by NOTCH3 0.250395 0.601
R-HSA-9707616 Heme signaling 0.093094 1.031
R-HSA-1266695 Interleukin-7 signaling 0.082149 1.085
R-HSA-73887 Death Receptor Signaling 0.269572 0.569
R-HSA-111996 Ca-dependent events 0.178139 0.749
R-HSA-5683057 MAPK family signaling cascades 0.330047 0.481
R-HSA-69205 G1/S-Specific Transcription 0.140812 0.851
R-HSA-111471 Apoptotic factor-mediated response 0.296449 0.528
R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.307130 0.513
R-HSA-9694631 Maturation of nucleoprotein 0.307130 0.513
R-HSA-1489509 DAG and IP3 signaling 0.194572 0.711
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.334495 0.476
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.274000 0.562
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.211187 0.675
R-HSA-112043 PLC beta mediated events 0.284172 0.546
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.414486 0.382
R-HSA-9700206 Signaling by ALK in cancer 0.274000 0.562
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.057812 1.238
R-HSA-216083 Integrin cell surface interactions 0.378352 0.422
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.312221 0.506
R-HSA-9678108 SARS-CoV-1 Infection 0.344577 0.463
R-HSA-112040 G-protein mediated events 0.317806 0.498
R-HSA-9694635 Translation of Structural Proteins 0.372931 0.428
R-HSA-5633007 Regulation of TP53 Activity 0.289807 0.538
R-HSA-9830369 Kidney development 0.317806 0.498
R-HSA-186712 Regulation of beta-cell development 0.272916 0.564
R-HSA-982772 Growth hormone receptor signaling 0.358164 0.446
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.394496 0.404
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.200021 0.699
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.426193 0.370
R-HSA-6807070 PTEN Regulation 0.426373 0.370
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.432144 0.364
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.432144 0.364
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.432144 0.364
R-HSA-9833109 Evasion by RSV of host interferon responses 0.432144 0.364
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.436567 0.360
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.440773 0.356
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.440773 0.356
R-HSA-9675108 Nervous system development 0.440999 0.356
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.446839 0.350
R-HSA-72172 mRNA Splicing 0.447083 0.350
R-HSA-1855170 IPs transport between nucleus and cytosol 0.449271 0.347
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.449271 0.347
R-HSA-5675482 Regulation of necroptotic cell death 0.449271 0.347
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.449271 0.347
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.449271 0.347
R-HSA-9733709 Cardiogenesis 0.449271 0.347
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.449271 0.347
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.457641 0.339
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.457641 0.339
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.457641 0.339
R-HSA-180534 Vpu mediated degradation of CD4 0.457641 0.339
R-HSA-1482788 Acyl chain remodelling of PC 0.457641 0.339
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.458226 0.339
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.462049 0.335
R-HSA-5696400 Dual Incision in GG-NER 0.465884 0.332
R-HSA-180746 Nuclear import of Rev protein 0.465884 0.332
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.465884 0.332
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.465884 0.332
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.465884 0.332
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.465884 0.332
R-HSA-1980145 Signaling by NOTCH2 0.465884 0.332
R-HSA-5205647 Mitophagy 0.465884 0.332
R-HSA-168638 NOD1/2 Signaling Pathway 0.465884 0.332
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.466075 0.332
R-HSA-9758941 Gastrulation 0.469981 0.328
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.474002 0.324
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.474002 0.324
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.474002 0.324
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.474002 0.324
R-HSA-169911 Regulation of Apoptosis 0.474002 0.324
R-HSA-2559585 Oncogene Induced Senescence 0.474002 0.324
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.477013 0.321
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.481997 0.317
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.481997 0.317
R-HSA-3371511 HSF1 activation 0.481997 0.317
R-HSA-114604 GPVI-mediated activation cascade 0.481997 0.317
R-HSA-6804757 Regulation of TP53 Degradation 0.481997 0.317
R-HSA-8853659 RET signaling 0.481997 0.317
R-HSA-69306 DNA Replication 0.485474 0.314
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.486848 0.313
R-HSA-68882 Mitotic Anaphase 0.486856 0.313
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.489872 0.310
R-HSA-4641258 Degradation of DVL 0.489872 0.310
R-HSA-4641257 Degradation of AXIN 0.489872 0.310
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.489872 0.310
R-HSA-419037 NCAM1 interactions 0.489872 0.310
R-HSA-8948216 Collagen chain trimerization 0.489872 0.310
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.490120 0.310
R-HSA-8957275 Post-translational protein phosphorylation 0.496567 0.304
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.497627 0.303
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.497627 0.303
R-HSA-9614085 FOXO-mediated transcription 0.501383 0.300
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.505264 0.296
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.505264 0.296
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.505264 0.296
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.505264 0.296
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.505264 0.296
R-HSA-8953750 Transcriptional Regulation by E2F6 0.505264 0.296
R-HSA-69541 Stabilization of p53 0.505264 0.296
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.505264 0.296
R-HSA-201556 Signaling by ALK 0.505264 0.296
R-HSA-69618 Mitotic Spindle Checkpoint 0.506169 0.296
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.512786 0.290
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.512786 0.290
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.512786 0.290
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.512786 0.290
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.512786 0.290
R-HSA-177243 Interactions of Rev with host cellular proteins 0.512786 0.290
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.512786 0.290
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.512786 0.290
R-HSA-167169 HIV Transcription Elongation 0.512786 0.290
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.512786 0.290
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.512786 0.290
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.512786 0.290
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.512786 0.290
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.512786 0.290
R-HSA-202433 Generation of second messenger molecules 0.512786 0.290
R-HSA-1251985 Nuclear signaling by ERBB4 0.512786 0.290
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.515652 0.288
R-HSA-9842860 Regulation of endogenous retroelements 0.515652 0.288
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.520195 0.284
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.520195 0.284
R-HSA-5362768 Hh mutants are degraded by ERAD 0.520195 0.284
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.520195 0.284
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.520195 0.284
R-HSA-3214841 PKMTs methylate histone lysines 0.520195 0.284
R-HSA-9694548 Maturation of spike protein 0.520195 0.284
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.527490 0.278
R-HSA-167161 HIV Transcription Initiation 0.527490 0.278
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.527490 0.278
R-HSA-9932298 Degradation of CRY and PER proteins 0.527490 0.278
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.527490 0.278
R-HSA-9683701 Translation of Structural Proteins 0.527490 0.278
R-HSA-5696398 Nucleotide Excision Repair 0.534253 0.272
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.534253 0.272
R-HSA-73776 RNA Polymerase II Promoter Escape 0.541753 0.266
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.541753 0.266
R-HSA-211000 Gene Silencing by RNA 0.543370 0.265
R-HSA-8953854 Metabolism of RNA 0.548543 0.261
R-HSA-2172127 DAP12 interactions 0.548722 0.261
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.548722 0.261
R-HSA-3214858 RMTs methylate histone arginines 0.548722 0.261
R-HSA-9907900 Proteasome assembly 0.548722 0.261
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.552307 0.258
R-HSA-72306 tRNA processing 0.552307 0.258
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.555586 0.255
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.555586 0.255
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.555586 0.255
R-HSA-4608870 Asymmetric localization of PCP proteins 0.555586 0.255
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.555586 0.255
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.555586 0.255
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.555586 0.255
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.555586 0.255
R-HSA-9824272 Somitogenesis 0.555586 0.255
R-HSA-418555 G alpha (s) signalling events 0.555869 0.255
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.556811 0.254
R-HSA-166166 MyD88-independent TLR4 cascade 0.556811 0.254
R-HSA-202403 TCR signaling 0.556811 0.254
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.559414 0.252
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.562346 0.250
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.562346 0.250
R-HSA-1483249 Inositol phosphate metabolism 0.565616 0.247
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.569003 0.245
R-HSA-437239 Recycling pathway of L1 0.569003 0.245
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.578586 0.238
R-HSA-9766229 Degradation of CDH1 0.582017 0.235
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.582017 0.235
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.582017 0.235
R-HSA-109704 PI3K Cascade 0.588376 0.230
R-HSA-373760 L1CAM interactions 0.591271 0.228
R-HSA-9609646 HCMV Infection 0.592304 0.227
R-HSA-1169091 Activation of NF-kappaB in B cells 0.594639 0.226
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.594639 0.226
R-HSA-5358346 Hedgehog ligand biogenesis 0.594639 0.226
R-HSA-1852241 Organelle biogenesis and maintenance 0.595020 0.225
R-HSA-1592230 Mitochondrial biogenesis 0.595436 0.225
R-HSA-112382 Formation of RNA Pol II elongation complex 0.600807 0.221
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.600807 0.221
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.600807 0.221
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.606882 0.217
R-HSA-8948751 Regulation of PTEN stability and activity 0.606882 0.217
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.611780 0.213
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.613758 0.212
R-HSA-3700989 Transcriptional Regulation by TP53 0.614475 0.211
R-HSA-983712 Ion channel transport 0.617001 0.210
R-HSA-5617833 Cilium Assembly 0.620227 0.207
R-HSA-168898 Toll-like Receptor Cascades 0.623434 0.205
R-HSA-162909 Host Interactions of HIV factors 0.623705 0.205
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.624559 0.204
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.624559 0.204
R-HSA-2262752 Cellular responses to stress 0.626456 0.203
R-HSA-112399 IRS-mediated signalling 0.630274 0.200
R-HSA-5621480 Dectin-2 family 0.630274 0.200
R-HSA-2980766 Nuclear Envelope Breakdown 0.630274 0.200
R-HSA-9764561 Regulation of CDH1 Function 0.630274 0.200
R-HSA-6782135 Dual incision in TC-NER 0.635902 0.197
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.635902 0.197
R-HSA-422475 Axon guidance 0.636846 0.196
R-HSA-194441 Metabolism of non-coding RNA 0.641444 0.193
R-HSA-191859 snRNP Assembly 0.641444 0.193
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.641444 0.193
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.641444 0.193
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.646903 0.189
R-HSA-8873719 RAB geranylgeranylation 0.646903 0.189
R-HSA-8943724 Regulation of PTEN gene transcription 0.646903 0.189
R-HSA-351202 Metabolism of polyamines 0.646903 0.189
R-HSA-389948 Co-inhibition by PD-1 0.651464 0.186
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.651464 0.186
R-HSA-2428928 IRS-related events triggered by IGF1R 0.652279 0.186
R-HSA-168325 Viral Messenger RNA Synthesis 0.652279 0.186
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.652279 0.186
R-HSA-9793380 Formation of paraxial mesoderm 0.652279 0.186
R-HSA-450294 MAP kinase activation 0.652279 0.186
R-HSA-1442490 Collagen degradation 0.652279 0.186
R-HSA-9679506 SARS-CoV Infections 0.656102 0.183
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.657573 0.182
R-HSA-6784531 tRNA processing in the nucleus 0.657573 0.182
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.657573 0.182
R-HSA-375165 NCAM signaling for neurite out-growth 0.657573 0.182
R-HSA-186797 Signaling by PDGF 0.657573 0.182
R-HSA-376176 Signaling by ROBO receptors 0.660471 0.180
R-HSA-1474228 Degradation of the extracellular matrix 0.661412 0.180
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.662787 0.179
R-HSA-69615 G1/S DNA Damage Checkpoints 0.662787 0.179
R-HSA-74751 Insulin receptor signalling cascade 0.667922 0.175
R-HSA-2428924 IGF1R signaling cascade 0.667922 0.175
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.667922 0.175
R-HSA-5357801 Programmed Cell Death 0.669311 0.174
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.672979 0.172
R-HSA-1234174 Cellular response to hypoxia 0.672979 0.172
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.677960 0.169
R-HSA-5693606 DNA Double Strand Break Response 0.682864 0.166
R-HSA-196807 Nicotinate metabolism 0.682864 0.166
R-HSA-1266738 Developmental Biology 0.684539 0.165
R-HSA-167172 Transcription of the HIV genome 0.687695 0.163
R-HSA-5218859 Regulated Necrosis 0.687695 0.163
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.687695 0.163
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.687695 0.163
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.687695 0.163
R-HSA-5673001 RAF/MAP kinase cascade 0.696133 0.157
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.697137 0.157
R-HSA-69202 Cyclin E associated events during G1/S transition 0.697137 0.157
R-HSA-448424 Interleukin-17 signaling 0.697137 0.157
R-HSA-3000178 ECM proteoglycans 0.701751 0.154
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.701751 0.154
R-HSA-162599 Late Phase of HIV Life Cycle 0.702601 0.153
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.702601 0.153
R-HSA-5578749 Transcriptional regulation by small RNAs 0.706295 0.151
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.706295 0.151
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.706295 0.151
R-HSA-8953897 Cellular responses to stimuli 0.707003 0.151
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.710770 0.148
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.710770 0.148
R-HSA-5684996 MAPK1/MAPK3 signaling 0.712627 0.147
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.715177 0.146
R-HSA-1236394 Signaling by ERBB4 0.715177 0.146
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.719517 0.143
R-HSA-8852135 Protein ubiquitination 0.719517 0.143
R-HSA-1169408 ISG15 antiviral mechanism 0.719517 0.143
R-HSA-71403 Citric acid cycle (TCA cycle) 0.719517 0.143
R-HSA-9679191 Potential therapeutics for SARS 0.727692 0.138
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.728000 0.138
R-HSA-162906 HIV Infection 0.729009 0.137
R-HSA-5619084 ABC transporter disorders 0.732146 0.135
R-HSA-4086400 PCP/CE pathway 0.732146 0.135
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.739554 0.131
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.739554 0.131
R-HSA-9833482 PKR-mediated signaling 0.740249 0.131
R-HSA-72312 rRNA processing 0.741338 0.130
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.748108 0.126
R-HSA-9610379 HCMV Late Events 0.748160 0.126
R-HSA-162587 HIV Life Cycle 0.748160 0.126
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.750974 0.124
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.751948 0.124
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.755415 0.122
R-HSA-109581 Apoptosis 0.761962 0.118
R-HSA-141424 Amplification of signal from the kinetochores 0.763123 0.117
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.763123 0.117
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.763123 0.117
R-HSA-9645723 Diseases of programmed cell death 0.773796 0.111
R-HSA-1236974 ER-Phagosome pathway 0.777246 0.109
R-HSA-202424 Downstream TCR signaling 0.780644 0.108
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.783990 0.106
R-HSA-418594 G alpha (i) signalling events 0.784351 0.105
R-HSA-5621481 C-type lectin receptors (CLRs) 0.787614 0.104
R-HSA-74752 Signaling by Insulin receptor 0.790530 0.102
R-HSA-156842 Eukaryotic Translation Elongation 0.790530 0.102
R-HSA-2682334 EPH-Ephrin signaling 0.790530 0.102
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.793726 0.100
R-HSA-388841 Regulation of T cell activation by CD28 family 0.794423 0.100
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.794822 0.100
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.796873 0.099
R-HSA-1474290 Collagen formation 0.796873 0.099
R-HSA-9837999 Mitochondrial protein degradation 0.796873 0.099
R-HSA-72764 Eukaryotic Translation Termination 0.803025 0.095
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.803025 0.095
R-HSA-199991 Membrane Trafficking 0.804688 0.094
R-HSA-6807878 COPI-mediated anterograde transport 0.806031 0.094
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.806031 0.094
R-HSA-157579 Telomere Maintenance 0.808991 0.092
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.811907 0.090
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.811907 0.090
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.811907 0.090
R-HSA-193704 p75 NTR receptor-mediated signalling 0.814778 0.089
R-HSA-9694516 SARS-CoV-2 Infection 0.816599 0.088
R-HSA-70171 Glycolysis 0.817605 0.087
R-HSA-382556 ABC-family proteins mediated transport 0.817605 0.087
R-HSA-9009391 Extra-nuclear estrogen signaling 0.820389 0.086
R-HSA-9020702 Interleukin-1 signaling 0.820389 0.086
R-HSA-2559580 Oxidative Stress Induced Senescence 0.823131 0.085
R-HSA-1483255 PI Metabolism 0.823131 0.085
R-HSA-9860931 Response of endothelial cells to shear stress 0.828491 0.082
R-HSA-9833110 RSV-host interactions 0.831110 0.080
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.833700 0.079
R-HSA-418346 Platelet homeostasis 0.836228 0.078
R-HSA-1236975 Antigen processing-Cross presentation 0.841193 0.075
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.841193 0.075
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.841398 0.075
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.843618 0.074
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.843618 0.074
R-HSA-2871796 FCERI mediated MAPK activation 0.850676 0.070
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.852957 0.069
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.852957 0.069
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.854069 0.069
R-HSA-1483206 Glycerophospholipid biosynthesis 0.854069 0.069
R-HSA-9855142 Cellular responses to mechanical stimuli 0.855204 0.068
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.859595 0.066
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.859595 0.066
R-HSA-1483257 Phospholipid metabolism 0.861211 0.065
R-HSA-909733 Interferon alpha/beta signaling 0.861741 0.065
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.861741 0.065
R-HSA-2029485 Role of phospholipids in phagocytosis 0.861741 0.065
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.861741 0.065
R-HSA-70326 Glucose metabolism 0.865934 0.063
R-HSA-913531 Interferon Signaling 0.866755 0.062
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.870002 0.060
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.870002 0.060
R-HSA-68875 Mitotic Prophase 0.871989 0.059
R-HSA-73886 Chromosome Maintenance 0.873946 0.059
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.873946 0.059
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.875873 0.058
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.875873 0.058
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.877771 0.057
R-HSA-194138 Signaling by VEGF 0.883292 0.054
R-HSA-8951664 Neddylation 0.883977 0.054
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.885077 0.053
R-HSA-114608 Platelet degranulation 0.886835 0.052
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.891949 0.050
R-HSA-9705683 SARS-CoV-2-host interactions 0.893493 0.049
R-HSA-9843745 Adipogenesis 0.895229 0.048
R-HSA-8856688 Golgi-to-ER retrograde transport 0.896832 0.047
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.898411 0.047
R-HSA-9824446 Viral Infection Pathways 0.898565 0.046
R-HSA-9018519 Estrogen-dependent gene expression 0.904488 0.044
R-HSA-8939211 ESR-mediated signaling 0.904667 0.044
R-HSA-1474244 Extracellular matrix organization 0.905196 0.043
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.905950 0.043
R-HSA-9948299 Ribosome-associated quality control 0.907389 0.042
R-HSA-9664407 Parasite infection 0.910203 0.041
R-HSA-9664417 Leishmania phagocytosis 0.910203 0.041
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.910203 0.041
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.911578 0.040
R-HSA-5619115 Disorders of transmembrane transporters 0.915797 0.038
R-HSA-2871837 FCERI mediated NF-kB activation 0.916870 0.038
R-HSA-199977 ER to Golgi Anterograde Transport 0.920631 0.036
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.925384 0.034
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.926527 0.033
R-HSA-446652 Interleukin-1 family signaling 0.926527 0.033
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.929853 0.032
R-HSA-449147 Signaling by Interleukins 0.931739 0.031
R-HSA-877300 Interferon gamma signaling 0.934055 0.030
R-HSA-597592 Post-translational protein modification 0.937617 0.028
R-HSA-76002 Platelet activation, signaling and aggregation 0.940070 0.027
R-HSA-5653656 Vesicle-mediated transport 0.940557 0.027
R-HSA-5619102 SLC transporter disorders 0.941723 0.026
R-HSA-9824443 Parasitic Infection Pathways 0.945186 0.024
R-HSA-9658195 Leishmania infection 0.945186 0.024
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.947350 0.023
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.947699 0.023
R-HSA-9664433 Leishmania parasite growth and survival 0.947699 0.023
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.949292 0.023
R-HSA-1280215 Cytokine Signaling in Immune system 0.950140 0.022
R-HSA-611105 Respiratory electron transport 0.951591 0.022
R-HSA-168255 Influenza Infection 0.952334 0.021
R-HSA-948021 Transport to the Golgi and subsequent modification 0.966611 0.015
R-HSA-72766 Translation 0.969086 0.014
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.978702 0.009
R-HSA-9006931 Signaling by Nuclear Receptors 0.981252 0.008
R-HSA-9711123 Cellular response to chemical stress 0.988198 0.005
R-HSA-388396 GPCR downstream signalling 0.994069 0.003
R-HSA-6798695 Neutrophil degranulation 0.994855 0.002
R-HSA-112316 Neuronal System 0.995583 0.002
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.996218 0.002
R-HSA-196854 Metabolism of vitamins and cofactors 0.997361 0.001
R-HSA-168249 Innate Immune System 0.997459 0.001
R-HSA-5663205 Infectious disease 0.997649 0.001
R-HSA-372790 Signaling by GPCR 0.997716 0.001
R-HSA-392499 Metabolism of proteins 0.998461 0.001
R-HSA-109582 Hemostasis 0.998491 0.001
R-HSA-1643685 Disease 0.998717 0.001
R-HSA-446203 Asparagine N-linked glycosylation 0.998954 0.000
R-HSA-1280218 Adaptive Immune System 0.999157 0.000
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.999377 0.000
R-HSA-382551 Transport of small molecules 0.999486 0.000
R-HSA-71291 Metabolism of amino acids and derivatives 0.999953 0.000
R-HSA-168256 Immune System 0.999975 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-556833 Metabolism of lipids 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 -0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.856 0.805 1 0.803
KISKIS 0.848 0.781 1 0.748
CDK19CDK19 0.848 0.828 1 0.807
CDK18CDK18 0.848 0.835 1 0.821
CDK17CDK17 0.846 0.843 1 0.853
P38DP38D 0.843 0.854 1 0.862
P38GP38G 0.842 0.849 1 0.862
CDK7CDK7 0.840 0.820 1 0.775
JNK2JNK2 0.840 0.855 1 0.820
CDK8CDK8 0.840 0.819 1 0.771
CDK3CDK3 0.840 0.730 1 0.847
ERK1ERK1 0.837 0.824 1 0.804
CDK16CDK16 0.837 0.802 1 0.840
DYRK2DYRK2 0.837 0.774 1 0.712
CDK1CDK1 0.836 0.802 1 0.799
P38BP38B 0.835 0.834 1 0.789
DYRK4DYRK4 0.834 0.771 1 0.813
HIPK4HIPK4 0.832 0.599 1 0.492
CDK13CDK13 0.832 0.808 1 0.796
CDK12CDK12 0.830 0.806 1 0.818
HIPK1HIPK1 0.828 0.727 1 0.691
CDK5CDK5 0.827 0.768 1 0.744
DYRK1BDYRK1B 0.827 0.751 1 0.765
JNK3JNK3 0.826 0.831 1 0.792
CDK10CDK10 0.826 0.755 1 0.794
CDK14CDK14 0.825 0.797 1 0.777
CLK3CLK3 0.824 0.539 1 0.460
P38AP38A 0.822 0.803 1 0.715
CDK9CDK9 0.821 0.785 1 0.787
HIPK3HIPK3 0.818 0.709 1 0.664
DYRK1ADYRK1A 0.818 0.649 1 0.674
ERK2ERK2 0.817 0.801 1 0.750
CDK4CDK4 0.815 0.786 1 0.826
CDK6CDK6 0.812 0.761 1 0.798
SRPK1SRPK1 0.812 0.390 -3 0.766
JNK1JNK1 0.809 0.747 1 0.821
NLKNLK 0.809 0.718 1 0.495
DYRK3DYRK3 0.806 0.571 1 0.654
CLK2CLK2 0.804 0.438 -3 0.765
MAKMAK 0.803 0.554 -2 0.858
SRPK2SRPK2 0.801 0.317 -3 0.694
ERK5ERK5 0.800 0.419 1 0.413
CLK1CLK1 0.798 0.433 -3 0.752
CDK2CDK2 0.798 0.590 1 0.670
ICKICK 0.794 0.422 -3 0.849
CLK4CLK4 0.794 0.401 -3 0.774
MOKMOK 0.790 0.514 1 0.577
CDKL5CDKL5 0.789 0.217 -3 0.811
PRKD1PRKD1 0.784 0.100 -3 0.840
SRPK3SRPK3 0.783 0.274 -3 0.733
MTORMTOR 0.782 0.199 1 0.285
PRP4PRP4 0.781 0.473 -3 0.779
CDKL1CDKL1 0.781 0.180 -3 0.813
COTCOT 0.780 -0.084 2 0.705
PRKD2PRKD2 0.778 0.084 -3 0.783
CDC7CDC7 0.776 -0.040 1 0.116
MOSMOS 0.774 0.022 1 0.159
PIM3PIM3 0.773 0.013 -3 0.844
CHAK2CHAK2 0.773 0.043 -1 0.853
TBK1TBK1 0.773 -0.114 1 0.083
NDR2NDR2 0.773 0.018 -3 0.841
AURCAURC 0.768 0.057 -2 0.672
ERK7ERK7 0.768 0.236 2 0.386
PRPKPRPK 0.767 -0.079 -1 0.822
IKKEIKKE 0.766 -0.138 1 0.082
ATRATR 0.766 -0.024 1 0.153
NDR1NDR1 0.765 -0.023 -3 0.838
RSK2RSK2 0.765 0.022 -3 0.786
P90RSKP90RSK 0.765 0.030 -3 0.796
CAMK1BCAMK1B 0.764 -0.019 -3 0.859
PIM1PIM1 0.763 0.047 -3 0.788
GCN2GCN2 0.763 -0.186 2 0.640
PKN3PKN3 0.763 -0.040 -3 0.838
RAF1RAF1 0.762 -0.168 1 0.098
SKMLCKSKMLCK 0.761 -0.024 -2 0.858
RSK3RSK3 0.761 0.003 -3 0.782
MAPKAPK3MAPKAPK3 0.761 -0.009 -3 0.791
MST4MST4 0.761 -0.049 2 0.709
NUAK2NUAK2 0.761 0.008 -3 0.840
LATS2LATS2 0.761 -0.015 -5 0.736
IKKBIKKB 0.761 -0.158 -2 0.743
ULK2ULK2 0.760 -0.190 2 0.641
NEK6NEK6 0.760 -0.078 -2 0.818
PRKD3PRKD3 0.760 0.039 -3 0.750
PKCDPKCD 0.760 -0.020 2 0.618
MAPKAPK2MAPKAPK2 0.760 0.011 -3 0.752
BMPR2BMPR2 0.759 -0.149 -2 0.870
CAMLCKCAMLCK 0.759 0.004 -2 0.855
NIKNIK 0.758 -0.045 -3 0.873
TGFBR2TGFBR2 0.758 -0.076 -2 0.773
AMPKA1AMPKA1 0.757 -0.030 -3 0.850
P70S6KBP70S6KB 0.757 0.006 -3 0.802
RIPK3RIPK3 0.757 -0.130 3 0.720
PDHK4PDHK4 0.757 -0.187 1 0.164
DAPK2DAPK2 0.757 -0.008 -3 0.866
WNK1WNK1 0.757 -0.099 -2 0.874
IKKAIKKA 0.755 -0.081 -2 0.733
AMPKA2AMPKA2 0.755 -0.009 -3 0.822
PDHK1PDHK1 0.755 -0.169 1 0.144
PKN2PKN2 0.755 -0.074 -3 0.832
MLK2MLK2 0.755 -0.083 2 0.673
PKACGPKACG 0.755 -0.014 -2 0.734
DSTYKDSTYK 0.754 -0.186 2 0.698
TSSK1TSSK1 0.754 -0.028 -3 0.871
PHKG1PHKG1 0.754 -0.046 -3 0.826
MNK2MNK2 0.753 -0.024 -2 0.797
MPSK1MPSK1 0.753 0.095 1 0.171
PAK6PAK6 0.753 0.001 -2 0.737
PAK3PAK3 0.753 -0.043 -2 0.807
PAK1PAK1 0.753 -0.026 -2 0.809
IRE1IRE1 0.752 -0.092 1 0.096
IRE2IRE2 0.752 -0.062 2 0.606
MNK1MNK1 0.752 0.002 -2 0.802
ULK1ULK1 0.752 -0.176 -3 0.821
LATS1LATS1 0.751 0.033 -3 0.860
MARK4MARK4 0.751 -0.072 4 0.848
RSK4RSK4 0.751 0.025 -3 0.760
PKACBPKACB 0.751 0.038 -2 0.677
GRK1GRK1 0.750 -0.051 -2 0.778
MLK3MLK3 0.750 -0.072 2 0.573
AURBAURB 0.749 0.012 -2 0.666
CAMK2DCAMK2D 0.749 -0.092 -3 0.844
NEK7NEK7 0.749 -0.204 -3 0.831
CAMK2GCAMK2G 0.749 -0.151 2 0.641
NUAK1NUAK1 0.749 -0.022 -3 0.796
TSSK2TSSK2 0.749 -0.079 -5 0.821
AKT2AKT2 0.749 0.044 -3 0.699
MLK1MLK1 0.748 -0.187 2 0.638
MELKMELK 0.748 -0.057 -3 0.811
BMPR1BBMPR1B 0.748 -0.048 1 0.088
PKCBPKCB 0.748 -0.046 2 0.572
PINK1PINK1 0.748 0.173 1 0.316
PKCAPKCA 0.748 -0.032 2 0.565
MASTLMASTL 0.748 -0.164 -2 0.805
PKCZPKCZ 0.747 -0.045 2 0.625
PKG2PKG2 0.747 0.005 -2 0.678
NIM1NIM1 0.747 -0.100 3 0.722
CHAK1CHAK1 0.747 -0.089 2 0.681
WNK3WNK3 0.746 -0.219 1 0.099
DNAPKDNAPK 0.746 -0.050 1 0.146
PIM2PIM2 0.746 0.046 -3 0.757
HUNKHUNK 0.746 -0.189 2 0.651
NEK9NEK9 0.746 -0.194 2 0.677
GRK7GRK7 0.745 -0.013 1 0.129
PKCGPKCG 0.745 -0.054 2 0.569
ALK4ALK4 0.745 -0.055 -2 0.812
VRK2VRK2 0.745 0.039 1 0.201
BUB1BUB1 0.744 0.114 -5 0.774
GRK5GRK5 0.744 -0.183 -3 0.827
QSKQSK 0.744 -0.027 4 0.835
SGK3SGK3 0.744 -0.004 -3 0.767
ATMATM 0.744 -0.090 1 0.122
RIPK1RIPK1 0.743 -0.201 1 0.084
CAMK4CAMK4 0.743 -0.104 -3 0.815
DLKDLK 0.743 -0.210 1 0.110
MSK2MSK2 0.743 -0.035 -3 0.754
PRKXPRKX 0.743 0.048 -3 0.686
TGFBR1TGFBR1 0.743 -0.059 -2 0.787
PAK2PAK2 0.743 -0.054 -2 0.793
PKRPKR 0.743 -0.102 1 0.116
SMG1SMG1 0.742 -0.067 1 0.140
MSK1MSK1 0.742 -0.011 -3 0.761
BCKDKBCKDK 0.741 -0.189 -1 0.729
GSK3AGSK3A 0.741 0.172 4 0.417
CAMK2ACAMK2A 0.741 -0.037 2 0.625
DCAMKL1DCAMKL1 0.740 -0.033 -3 0.789
ANKRD3ANKRD3 0.740 -0.210 1 0.112
YSK4YSK4 0.739 -0.163 1 0.085
NEK2NEK2 0.739 -0.143 2 0.670
CHK1CHK1 0.738 -0.039 -3 0.840
BRSK2BRSK2 0.738 -0.084 -3 0.814
PKCHPKCH 0.738 -0.081 2 0.557
TTBK2TTBK2 0.737 -0.214 2 0.563
CAMK2BCAMK2B 0.737 -0.083 2 0.612
AKT1AKT1 0.737 0.019 -3 0.717
PAK5PAK5 0.737 -0.019 -2 0.679
SIKSIK 0.737 -0.044 -3 0.762
TLK2TLK2 0.736 -0.117 1 0.092
GRK6GRK6 0.735 -0.190 1 0.097
QIKQIK 0.735 -0.115 -3 0.826
BRSK1BRSK1 0.735 -0.071 -3 0.795
PLK4PLK4 0.735 -0.148 2 0.529
MAPKAPK5MAPKAPK5 0.735 -0.070 -3 0.740
MLK4MLK4 0.735 -0.142 2 0.549
MYLK4MYLK4 0.734 -0.041 -2 0.777
MEK1MEK1 0.734 -0.168 2 0.700
PAK4PAK4 0.734 -0.016 -2 0.687
AURAAURA 0.734 -0.024 -2 0.640
PLK1PLK1 0.734 -0.173 -2 0.776
IRAK4IRAK4 0.734 -0.126 1 0.077
PKCTPKCT 0.734 -0.063 2 0.570
ACVR2BACVR2B 0.734 -0.098 -2 0.776
LKB1LKB1 0.733 0.027 -3 0.831
SSTKSSTK 0.733 -0.048 4 0.816
PHKG2PHKG2 0.733 -0.082 -3 0.792
PKACAPKACA 0.732 0.016 -2 0.631
P70S6KP70S6K 0.732 -0.016 -3 0.719
MARK3MARK3 0.732 -0.053 4 0.792
ACVR2AACVR2A 0.732 -0.108 -2 0.768
DCAMKL2DCAMKL2 0.732 -0.057 -3 0.812
CAMK1GCAMK1G 0.731 -0.057 -3 0.767
FAM20CFAM20C 0.731 -0.073 2 0.464
SNRKSNRK 0.731 -0.157 2 0.564
MST3MST3 0.731 -0.080 2 0.684
PKCIPKCI 0.730 -0.044 2 0.588
ALK2ALK2 0.730 -0.099 -2 0.790
AKT3AKT3 0.730 0.036 -3 0.644
PERKPERK 0.730 -0.150 -2 0.812
TAO3TAO3 0.729 -0.054 1 0.130
NEK5NEK5 0.729 -0.140 1 0.094
MEKK1MEKK1 0.729 -0.170 1 0.109
GRK4GRK4 0.729 -0.218 -2 0.788
SBKSBK 0.728 0.127 -3 0.592
MEK5MEK5 0.728 -0.175 2 0.679
MARK2MARK2 0.728 -0.075 4 0.757
PASKPASK 0.728 -0.029 -3 0.852
WNK4WNK4 0.728 -0.146 -2 0.859
BMPR1ABMPR1A 0.728 -0.072 1 0.080
ZAKZAK 0.727 -0.184 1 0.093
HRIHRI 0.727 -0.177 -2 0.828
PKN1PKN1 0.727 -0.035 -3 0.734
PBKPBK 0.727 0.008 1 0.142
DRAK1DRAK1 0.726 -0.177 1 0.073
PKCEPKCE 0.726 -0.017 2 0.559
PLK3PLK3 0.726 -0.157 2 0.615
SMMLCKSMMLCK 0.725 -0.039 -3 0.819
MEKK2MEKK2 0.725 -0.162 2 0.651
BRAFBRAF 0.724 -0.161 -4 0.821
PDK1PDK1 0.724 -0.063 1 0.137
MAP3K15MAP3K15 0.724 -0.080 1 0.107
GSK3BGSK3B 0.724 0.025 4 0.408
SGK1SGK1 0.724 0.044 -3 0.628
HGKHGK 0.723 -0.055 3 0.853
LOKLOK 0.722 -0.045 -2 0.774
NEK11NEK11 0.722 -0.143 1 0.123
MEKK6MEKK6 0.722 -0.099 1 0.109
GCKGCK 0.722 -0.063 1 0.109
TNIKTNIK 0.722 -0.035 3 0.856
TLK1TLK1 0.722 -0.162 -2 0.794
MARK1MARK1 0.722 -0.101 4 0.811
GRK2GRK2 0.722 -0.116 -2 0.683
MRCKAMRCKA 0.721 0.012 -3 0.758
CAMK1DCAMK1D 0.721 -0.030 -3 0.694
TAO2TAO2 0.721 -0.078 2 0.687
GAKGAK 0.721 -0.059 1 0.154
KHS1KHS1 0.721 -0.021 1 0.103
MRCKBMRCKB 0.720 0.010 -3 0.740
CAMKK2CAMKK2 0.720 -0.098 -2 0.778
ROCK2ROCK2 0.720 0.014 -3 0.792
NEK4NEK4 0.720 -0.134 1 0.082
DAPK3DAPK3 0.720 -0.026 -3 0.801
HASPINHASPIN 0.719 0.023 -1 0.707
MEKK3MEKK3 0.718 -0.236 1 0.103
CHK2CHK2 0.718 -0.007 -3 0.649
NEK8NEK8 0.717 -0.183 2 0.659
CK1ECK1E 0.717 -0.061 -3 0.495
SLKSLK 0.717 -0.044 -2 0.717
KHS2KHS2 0.716 -0.016 1 0.115
MINKMINK 0.716 -0.111 1 0.085
CAMKK1CAMKK1 0.716 -0.179 -2 0.774
HPK1HPK1 0.716 -0.078 1 0.109
NEK1NEK1 0.715 -0.121 1 0.077
LRRK2LRRK2 0.715 -0.044 2 0.690
TTBK1TTBK1 0.715 -0.185 2 0.496
CRIKCRIK 0.714 0.042 -3 0.721
CAMK1ACAMK1A 0.714 -0.013 -3 0.664
DMPK1DMPK1 0.713 0.040 -3 0.758
EEF2KEEF2K 0.713 -0.097 3 0.802
MST2MST2 0.712 -0.156 1 0.094
AAK1AAK1 0.711 0.024 1 0.164
CK1DCK1D 0.711 -0.032 -3 0.442
DAPK1DAPK1 0.711 -0.040 -3 0.781
BIKEBIKE 0.710 -0.020 1 0.151
PKG1PKG1 0.709 -0.027 -2 0.601
IRAK1IRAK1 0.708 -0.249 -1 0.717
MST1MST1 0.708 -0.140 1 0.084
CK1G1CK1G1 0.708 -0.100 -3 0.487
CK2A2CK2A2 0.707 -0.105 1 0.083
STK33STK33 0.707 -0.138 2 0.492
YSK1YSK1 0.707 -0.133 2 0.655
PDHK3_TYRPDHK3_TYR 0.707 0.170 4 0.889
LIMK2_TYRLIMK2_TYR 0.707 0.192 -3 0.888
NEK3NEK3 0.707 -0.114 1 0.110
ROCK1ROCK1 0.705 -0.006 -3 0.757
VRK1VRK1 0.705 -0.207 2 0.693
TAK1TAK1 0.704 -0.217 1 0.089
CK1A2CK1A2 0.703 -0.065 -3 0.441
GRK3GRK3 0.702 -0.129 -2 0.631
RIPK2RIPK2 0.702 -0.227 1 0.080
MEK2MEK2 0.702 -0.201 2 0.686
OSR1OSR1 0.700 -0.087 2 0.661
TESK1_TYRTESK1_TYR 0.700 0.083 3 0.832
PLK2PLK2 0.699 -0.104 -3 0.792
ASK1ASK1 0.699 -0.118 1 0.107
MYO3BMYO3B 0.698 -0.071 2 0.689
CK2A1CK2A1 0.698 -0.114 1 0.075
TAO1TAO1 0.697 -0.093 1 0.103
PKMYT1_TYRPKMYT1_TYR 0.697 0.129 3 0.807
TTKTTK 0.696 -0.094 -2 0.790
PDHK4_TYRPDHK4_TYR 0.695 0.050 2 0.735
MYO3AMYO3A 0.693 -0.099 1 0.102
MAP2K4_TYRMAP2K4_TYR 0.693 0.030 -1 0.826
RETRET 0.690 -0.086 1 0.124
MAP2K6_TYRMAP2K6_TYR 0.689 -0.007 -1 0.833
MAP2K7_TYRMAP2K7_TYR 0.689 -0.100 2 0.709
MST1RMST1R 0.689 -0.055 3 0.806
NEK10_TYRNEK10_TYR 0.688 -0.040 1 0.111
JAK2JAK2 0.687 -0.069 1 0.134
CSF1RCSF1R 0.687 -0.053 3 0.795
JAK1JAK1 0.687 -0.022 1 0.105
PINK1_TYRPINK1_TYR 0.686 -0.137 1 0.156
LIMK1_TYRLIMK1_TYR 0.686 -0.000 2 0.707
ALPHAK3ALPHAK3 0.686 -0.103 -1 0.736
ROS1ROS1 0.686 -0.082 3 0.763
YANK3YANK3 0.686 -0.078 2 0.321
PDHK1_TYRPDHK1_TYR 0.685 -0.067 -1 0.840
TNK1TNK1 0.684 -0.018 3 0.773
BMPR2_TYRBMPR2_TYR 0.684 -0.039 -1 0.814
ABL2ABL2 0.683 -0.057 -1 0.761
TYK2TYK2 0.683 -0.157 1 0.111
TNNI3K_TYRTNNI3K_TYR 0.683 -0.019 1 0.145
JAK3JAK3 0.682 -0.093 1 0.118
TNK2TNK2 0.682 -0.054 3 0.755
EPHA6EPHA6 0.682 -0.102 -1 0.804
TYRO3TYRO3 0.682 -0.131 3 0.793
FGFR1FGFR1 0.680 -0.023 3 0.752
ABL1ABL1 0.680 -0.067 -1 0.754
EPHB4EPHB4 0.680 -0.110 -1 0.776
STLK3STLK3 0.679 -0.184 1 0.080
TXKTXK 0.678 -0.078 1 0.087
FGFR2FGFR2 0.678 -0.048 3 0.768
LCKLCK 0.678 -0.063 -1 0.785
TEKTEK 0.677 -0.012 3 0.725
YES1YES1 0.677 -0.095 -1 0.811
KDRKDR 0.676 -0.074 3 0.766
DDR1DDR1 0.675 -0.135 4 0.789
BLKBLK 0.675 -0.063 -1 0.785
FGRFGR 0.675 -0.135 1 0.091
INSRRINSRR 0.673 -0.132 3 0.730
KITKIT 0.673 -0.112 3 0.784
HCKHCK 0.672 -0.132 -1 0.780
PDGFRBPDGFRB 0.671 -0.175 3 0.792
FLT3FLT3 0.671 -0.155 3 0.804
ITKITK 0.670 -0.142 -1 0.749
METMET 0.670 -0.091 3 0.789
PDGFRAPDGFRA 0.670 -0.159 3 0.797
AXLAXL 0.669 -0.145 3 0.767
DDR2DDR2 0.669 -0.030 3 0.716
EPHA4EPHA4 0.669 -0.108 2 0.616
MERTKMERTK 0.669 -0.136 3 0.777
FERFER 0.668 -0.193 1 0.104
CK1ACK1A 0.668 -0.081 -3 0.348
SRMSSRMS 0.667 -0.181 1 0.079
FGFR3FGFR3 0.667 -0.072 3 0.743
EPHB1EPHB1 0.666 -0.176 1 0.084
ALKALK 0.665 -0.137 3 0.710
EPHB3EPHB3 0.664 -0.167 -1 0.759
BMXBMX 0.664 -0.121 -1 0.675
FYNFYN 0.664 -0.092 -1 0.769
EPHB2EPHB2 0.663 -0.161 -1 0.748
PTK2BPTK2B 0.662 -0.090 -1 0.726
WEE1_TYRWEE1_TYR 0.661 -0.101 -1 0.706
FRKFRK 0.661 -0.143 -1 0.783
EPHA1EPHA1 0.661 -0.144 3 0.787
LTKLTK 0.660 -0.162 3 0.727
TECTEC 0.660 -0.153 -1 0.690
INSRINSR 0.660 -0.153 3 0.710
FLT4FLT4 0.658 -0.157 3 0.735
EPHA7EPHA7 0.658 -0.146 2 0.611
ERBB2ERBB2 0.657 -0.172 1 0.096
PTK6PTK6 0.657 -0.180 -1 0.696
FLT1FLT1 0.656 -0.153 -1 0.778
NTRK1NTRK1 0.656 -0.208 -1 0.764
NTRK2NTRK2 0.656 -0.197 3 0.744
NTRK3NTRK3 0.656 -0.142 -1 0.722
EGFREGFR 0.656 -0.118 1 0.078
BTKBTK 0.655 -0.225 -1 0.721
LYNLYN 0.655 -0.141 3 0.707
EPHA3EPHA3 0.654 -0.161 2 0.592
MUSKMUSK 0.653 -0.128 1 0.060
SRCSRC 0.653 -0.128 -1 0.764
MATKMATK 0.651 -0.115 -1 0.691
EPHA8EPHA8 0.651 -0.130 -1 0.744
FGFR4FGFR4 0.651 -0.114 -1 0.714
EPHA5EPHA5 0.648 -0.164 2 0.594
YANK2YANK2 0.648 -0.103 2 0.320
PTK2PTK2 0.647 -0.082 -1 0.741
CSKCSK 0.646 -0.161 2 0.622
ERBB4ERBB4 0.643 -0.107 1 0.078
SYKSYK 0.642 -0.107 -1 0.724
EPHA2EPHA2 0.641 -0.144 -1 0.706
IGF1RIGF1R 0.640 -0.161 3 0.644
CK1G3CK1G3 0.639 -0.100 -3 0.299
ZAP70ZAP70 0.639 -0.055 -1 0.650
FESFES 0.628 -0.158 -1 0.654
CK1G2CK1G2 0.620 -0.102 -3 0.397