Motif 739 (n=179)

Position-wise Probabilities

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uniprot genes site source protein function
A4FU49 SH3D21 S329 ochoa SH3 domain-containing protein 21 None
A5YM69 ARHGEF35 S340 ochoa Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) None
B5ME19 EIF3CL S166 ochoa Eukaryotic translation initiation factor 3 subunit C-like protein Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}.
F5H5P2 None S381 ochoa 2-oxoisovalerate dehydrogenase subunit alpha (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000256|ARBA:ARBA00037052, ECO:0000256|RuleBase:RU365014}.
H3BQZ7 HNRNPUL2-BSCL2 S161 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 None
O00221 NFKBIE S157 ochoa NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}.
O00562 PITPNM1 S382 ochoa|psp Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}.
O00566 MPHOSPH10 S289 ochoa U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}.
O15078 CEP290 S2369 ochoa Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300, ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332, ECO:0000269|PubMed:25552655}.
O15355 PPM1G S195 ochoa Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) None
O15541 RNF113A S253 ochoa E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). {ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
O43422 THAP12 S141 ochoa 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12) Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.
O43491 EPB41L2 S647 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O43491 EPB41L2 S682 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O43561 LAT S240 ochoa Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.
O43719 HTATSF1 Y650 ochoa 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}.
O43823 AKAP8 S339 ochoa A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}.
O60271 SPAG9 S314 ochoa C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
O60678 PRMT3 S27 ochoa Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:22795084, PubMed:23445220, PubMed:25728001, PubMed:31378783, PubMed:33495566, PubMed:39513743). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (PubMed:22795084). Also appears to methylate other ribosomal proteins (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (PubMed:25728001, PubMed:31378783, PubMed:39513743). Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis (PubMed:31378783). {ECO:0000250|UniProtKB:Q922H1, ECO:0000269|PubMed:22795084, ECO:0000269|PubMed:23445220, ECO:0000269|PubMed:25728001, ECO:0000269|PubMed:31378783, ECO:0000269|PubMed:33495566, ECO:0000269|PubMed:39513743}.
O60841 EIF5B S511 ochoa Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}.
O75113 N4BP1 S226 ochoa NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}.
O75113 N4BP1 S288 ochoa NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}.
O75121 MFAP3L S349 ochoa Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}.
O75151 PHF2 S458 ochoa Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.
O75362 ZNF217 S327 ochoa Zinc finger protein 217 Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.
O75554 WBP4 S323 ochoa WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}.
O75864 PPP1R37 S669 ochoa Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.
O94880 PHF14 S84 ochoa PHD finger protein 14 Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.
O95155 UBE4B S124 ochoa Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}.
P05067 APP S679 psp Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: [Amyloid-beta protein 42]: More effective reductant than amyloid-beta protein 40. May activate mononuclear phagocytes in the brain and elicit inflammatory responses.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
P08758 ANXA5 S135 ochoa Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
P11021 HSPA5 S86 ochoa Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}.
P11137 MAP2 S1133 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P11171 EPB41 S684 ochoa Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
P11277 SPTB S2060 ochoa Spectrin beta chain, erythrocytic (Beta-I spectrin) Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
P11388 TOP2A S1247 ochoa|psp DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}.
P12694 BCKDHA S347 ochoa|psp 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:7883996, ECO:0000269|PubMed:9582350}.
P12830 CDH1 Y754 ochoa|psp Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}.
P14314 PRKCSH S230 ochoa Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}.
P15170 GSPT1 S46 ochoa Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417105, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:2511002, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371}.
P17677 GAP43 S130 ochoa Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
P20810 CAST S297 ochoa Calpastatin (Calpain inhibitor) (Sperm BS-17 component) Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P22223 CDH3 Y700 ochoa Cadherin-3 (Placental cadherin) (P-cadherin) Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
P23246 SFPQ S521 ochoa Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}.
P29692 EEF1D S37 ochoa Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
P30414 NKTR S1061 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P35659 DEK S244 ochoa Protein DEK Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.
P36915 GNL1 S344 ochoa Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) Possible regulatory or functional link with the histocompatibility cluster.
P39880 CUX1 S1357 ochoa Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
P47712 PLA2G4A S437 ochoa|psp Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}.
P49736 MCM2 S108 ochoa|psp DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}.
P49792 RANBP2 S2493 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P50579 METAP2 S63 ochoa Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
P50579 METAP2 S74 ochoa Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
P52565 ARHGDIA S34 ochoa|psp Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.
P54277 PMS1 S507 ochoa PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) Probably involved in the repair of mismatches in DNA. {ECO:0000269|PubMed:10748105}.
P82970 HMGN5 S93 ochoa High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000250}.
Q01484 ANK2 S1732 ochoa Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
Q02952 AKAP12 S353 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q02952 AKAP12 S1259 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03188 CENPC S613 ochoa Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.
Q06546 GABPA S26 ochoa GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene.
Q07021 C1QBP S205 ochoa Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}.
Q07021 C1QBP S213 ochoa Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}.
Q12774 ARHGEF5 S340 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12888 TP53BP1 S301 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S1219 ochoa|psp TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13129 RLF S1277 ochoa Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) May be involved in transcriptional regulation.
Q13409 DYNC1I2 S51 ochoa Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}.
Q13501 SQSTM1 S342 ochoa Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q14141 SEPTIN6 S319 ochoa Septin-6 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}.
Q14207 NPAT S1173 ochoa Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
Q14671 PUM1 S124 ochoa Pumilio homolog 1 (HsPUM) (Pumilio-1) Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}.
Q14686 NCOA6 S1432 ochoa Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Q14789 GOLGB1 S38 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q14789 GOLGB1 S538 ochoa Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) May participate in forming intercisternal cross-bridges of the Golgi complex.
Q14980 NUMA1 S820 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15021 NCAPD2 S972 ochoa Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15054 POLD3 S269 ochoa DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}.
Q16891 IMMT S193 ochoa MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
Q1KMD3 HNRNPUL2 S161 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) None
Q2NKX8 ERCC6L S1134 ochoa DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}.
Q2TAZ0 ATG2A S765 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q5F1R6 DNAJC21 S423 ochoa DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}.
Q5F1R6 DNAJC21 S430 ochoa DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}.
Q5T481 RBM20 S876 ochoa RNA-binding protein 20 (RNA-binding motif protein 20) RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}.
Q5TAX3 TUT4 S156 ochoa Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}.
Q5TZA2 CROCC S462 ochoa Rootletin (Ciliary rootlet coiled-coil protein) Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.
Q5VTR2 RNF20 S138 ochoa E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
Q5VZL5 ZMYM4 S1064 ochoa Zinc finger MYM-type protein 4 (Zinc finger protein 262) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q63HN8 RNF213 S69 ochoa E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}.
Q6BDS2 BLTP3A S950 ochoa Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}.
Q6ISB3 GRHL2 S108 ochoa Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3) Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456, PubMed:29309642). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). {ECO:0000250|UniProtKB:Q8K5C0, ECO:0000269|PubMed:19015635, ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:23254293, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29309642, ECO:0000305|PubMed:12175488}.
Q6NZI2 CAVIN1 S202 ochoa Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.
Q6PKG0 LARP1 S228 ochoa La-related protein 1 (La ribonucleoprotein domain family member 1) RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
Q6VMQ6 ATF7IP S512 ochoa Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.
Q6WKZ4 RAB11FIP1 S758 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6Y7W6 GIGYF2 S335 ochoa GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}.
Q6ZMQ8 AATK S968 ochoa Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}.
Q71H61 ILDR2 S426 ochoa Immunoglobulin-like domain-containing receptor 2 (Angulin-3) May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}.
Q71RC2 LARP4 S74 ochoa La-related protein 4 (La ribonucleoprotein domain family member 4) RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}.
Q7Z3K3 POGZ S28 ochoa Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.
Q7Z589 EMSY S705 ochoa BRCA2-interacting transcriptional repressor EMSY Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.
Q86UP2 KTN1 S1244 ochoa Kinectin (CG-1 antigen) (Kinesin receptor) Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Q86US8 SMG6 S85 ochoa Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}.
Q86UU1 PHLDB1 S682 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86UU1 PHLDB1 S692 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86VM9 ZC3H18 S67 ochoa Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) None
Q86W50 METTL16 S455 ochoa RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}.
Q8IWU2 LMTK2 S601 ochoa Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) Phosphorylates PPP1C, phosphorylase b and CFTR.
Q8IYD8 FANCM S884 ochoa Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}.
Q8N5A5 ZGPAT S99 ochoa Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}.
Q8N7H5 PAF1 S466 ochoa RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}.
Q8N9T8 KRI1 S171 ochoa Protein KRI1 homolog None
Q8NG31 KNL1 S956 ochoa Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}.
Q8NG31 KNL1 S1773 ochoa Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}.
Q8NHZ8 CDC26 S42 ochoa Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). May recruit the E2 ubiquitin-conjugating enzymes to the complex (PubMed:18485873). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q8TAF3 WDR48 S617 ochoa WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:27650958, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}.
Q8TBN0 RAB3IL1 S67 ochoa Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269|PubMed:20937701}.
Q8TCU6 PREX1 S1169 psp Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Q8TEW0 PARD3 S958 ochoa Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
Q8WTS6 SETD7 S345 ochoa Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9) Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12540855, PubMed:12588998, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12588998, PubMed:16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:15525938, PubMed:16415881, PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:15525938, PubMed:16415881, PubMed:17108971). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity). {ECO:0000250|UniProtKB:Q8VHL1, ECO:0000269|PubMed:11779497, ECO:0000269|PubMed:11850410, ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:16415881, ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:35210392}.
Q8WYP5 AHCTF1 S1541 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92688 ANP32B Y148 ochoa Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}.
Q92734 TFG S50 ochoa Protein TFG (TRK-fused gene protein) Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.
Q92805 GOLGA1 S160 ochoa Golgin subfamily A member 1 (Golgin-97) Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23 (PubMed:29084197, PubMed:38552021). Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers (PubMed:34969853). {ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:38552021}.; FUNCTION: (Microbial infection) Plays an important role in poxvirus morphogenesis. Translocates into the viral factories where it may transport the membrane fragments and associated protein factors important for virus maturation to the sites of virion assembly. {ECO:0000269|PubMed:17276477}.
Q92922 SMARCC1 T828 ochoa SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q96HP0 DOCK6 S159 ochoa Dedicator of cytokinesis protein 6 Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}.
Q96JG6 VPS50 Y571 ochoa Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:25799061}.
Q96R06 SPAG5 S334 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96TC7 RMDN3 S233 ochoa Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.
Q99613 EIF3C S166 ochoa Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
Q9BSC4 NOL10 S551 ochoa Nucleolar protein 10 None
Q9BUR4 WRAP53 S112 ochoa Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}.
Q9BV36 MLPH S397 ochoa Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.
Q9BXB5 OSBPL10 S380 ochoa Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}.
Q9C0A6 SETD5 S541 ochoa Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}.
Q9GZR1 SENP6 S55 ochoa Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.
Q9GZZ9 UBA5 S381 ochoa Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}.
Q9H4L7 SMARCAD1 S127 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Q9H8G2 CAAP1 S301 ochoa Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}.
Q9H9Q2 COPS7B S227 ochoa COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.
Q9HA90 EFCC1 S394 ochoa EF-hand and coiled-coil domain-containing protein 1 (Coiled-coil domain-containing protein 48) None
Q9HB65 ELL3 S271 ochoa RNA polymerase II elongation factor ELL3 Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). {ECO:0000250, ECO:0000269|PubMed:10882741, ECO:0000269|PubMed:22195968}.
Q9HBM0 VEZT S677 ochoa Vezatin Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000250|UniProtKB:Q3ZK22}.; FUNCTION: (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}.
Q9HCK1 ZDBF2 S952 ochoa DBF4-type zinc finger-containing protein 2 None
Q9NVA2 SEPTIN11 S318 ochoa Septin-11 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}.
Q9NVT9 ARMC1 S120 ochoa Armadillo repeat-containing protein 1 In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}.
Q9NWV8 BABAM1 S47 ochoa BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Q9NXX6 NSMCE4A S63 ochoa Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}.
Q9NYD6 HOXC10 S122 ochoa Homeobox protein Hox-C10 (Homeobox protein Hox-3I) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Q9NYL9 TMOD3 S25 ochoa Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.
Q9NZT2 OGFR S403 ochoa Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Q9P0K7 RAI14 S318 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9P1A6 DLGAP2 S740 ochoa Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Q9P2G1 ANKIB1 S1058 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9P2I0 CPSF2 S419 ochoa Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}.
Q9UBL3 ASH2L S101 ochoa Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
Q9UBU6 FAM8A1 S83 ochoa Protein FAM8A1 (Autosomal highly conserved protein) Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}.
Q9UIG0 BAZ1B S161 ochoa Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}.
Q9UKL3 CASP8AP2 S1270 ochoa CASP8-associated protein 2 (FLICE-associated huge protein) Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.
Q9UKX2 MYH2 S1239 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9ULI0 ATAD2B S1338 ochoa ATPase family AAA domain-containing protein 2B None
Q9UQF2 MAPK8IP1 S421 psp C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}.
Q9Y2H9 MAST1 S687 ochoa Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}.
Q9Y2X9 ZNF281 S620 ochoa Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}.
Q9Y448 KNSTRN S237 ochoa Small kinetochore-associated protein (SKAP) (Kinetochore-localized astrin-binding protein) (Kinastrin) (Kinetochore-localized astrin/SPAG5-binding protein) (TRAF4-associated factor 1) Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}.
Q9Y490 TLN1 S2279 ochoa Talin-1 High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}.
Q9Y5A6 ZSCAN21 S208 ochoa Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). {ECO:0000250|UniProtKB:Q07231}.
Q9Y6X4 FAM169A S635 ochoa Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A) None
Q6NVY1 HIBCH S242 Sugiyama 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}.
Q8IZ69 TRMT2A S480 Sugiyama tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-) S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}.
P13639 EEF2 S578 Sugiyama Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
Q15906 VPS72 S71 ELM Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}.
P50990 CCT8 S243 Sugiyama T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
P05556 ITGB1 S503 Sugiyama Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072). {ECO:0000250|UniProtKB:P07228, ECO:0000250|UniProtKB:P09055, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943, ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:7523423}.; FUNCTION: [Isoform 2]: Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). {ECO:0000305|PubMed:2249781}.; FUNCTION: [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles. {ECO:0000250|UniProtKB:P09055}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.; FUNCTION: (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:20660204}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4. {ECO:0000269|PubMed:17945327}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus. {ECO:0000269|PubMed:16501085}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.; FUNCTION: (Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:32487760). Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression (PubMed:32487760). {ECO:0000269|PubMed:32487760}.; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis. {ECO:0000305|PubMed:21471204}.; FUNCTION: (Microbial infection) Facilitates rabies infection in a fibronectin-dependent manner and participates in rabies virus traffic after internalization. {ECO:0000269|PubMed:31666383}.
Q8NEF9 SRFBP1 S274 Sugiyama Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.
Q9NSE4 IARS2 S176 Sugiyama Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile)). {ECO:0000250|UniProtKB:P00956}.
P48444 ARCN1 S138 Sugiyama Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
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reactome_id name p -log10_p
R-HSA-141424 Amplification of signal from the kinetochores 0.000154 3.812
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.000154 3.812
R-HSA-69618 Mitotic Spindle Checkpoint 0.000066 4.183
R-HSA-69620 Cell Cycle Checkpoints 0.000148 3.831
R-HSA-68877 Mitotic Prometaphase 0.000264 3.578
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.000387 3.413
R-HSA-1640170 Cell Cycle 0.000497 3.304
R-HSA-69278 Cell Cycle, Mitotic 0.000737 3.133
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.000712 3.147
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.000691 3.161
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.000885 3.053
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.001294 2.888
R-HSA-2467813 Separation of Sister Chromatids 0.001681 2.774
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.003210 2.493
R-HSA-8863678 Neurodegenerative Diseases 0.005779 2.238
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.005779 2.238
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.010795 1.967
R-HSA-69190 DNA strand elongation 0.010960 1.960
R-HSA-6807878 COPI-mediated anterograde transport 0.009619 2.017
R-HSA-446728 Cell junction organization 0.010065 1.997
R-HSA-176974 Unwinding of DNA 0.009270 2.033
R-HSA-68882 Mitotic Anaphase 0.007854 2.105
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.008044 2.095
R-HSA-193704 p75 NTR receptor-mediated signalling 0.010738 1.969
R-HSA-68886 M Phase 0.009542 2.020
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.007850 2.105
R-HSA-9635465 Suppression of apoptosis 0.012423 1.906
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.016005 1.796
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.015977 1.797
R-HSA-69239 Synthesis of DNA 0.014622 1.835
R-HSA-69052 Switching of origins to a post-replicative state 0.016669 1.778
R-HSA-199977 ER to Golgi Anterograde Transport 0.014881 1.827
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.014151 1.849
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.016669 1.778
R-HSA-9856651 MITF-M-dependent gene expression 0.016110 1.793
R-HSA-421270 Cell-cell junction organization 0.016801 1.775
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.017897 1.747
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.019910 1.701
R-HSA-3214841 PKMTs methylate histone lysines 0.020272 1.693
R-HSA-1500931 Cell-Cell communication 0.020303 1.692
R-HSA-9645722 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 0.023566 1.628
R-HSA-5545483 Defective Mismatch Repair Associated With MLH1 0.023566 1.628
R-HSA-5632987 Defective Mismatch Repair Associated With PMS2 0.023566 1.628
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.024203 1.616
R-HSA-8876725 Protein methylation 0.022013 1.657
R-HSA-418990 Adherens junctions interactions 0.024986 1.602
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.028838 1.540
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.028838 1.540
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.028838 1.540
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.029672 1.528
R-HSA-9645723 Diseases of programmed cell death 0.029672 1.528
R-HSA-5358508 Mismatch Repair 0.031278 1.505
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.031278 1.505
R-HSA-9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 0.035141 1.454
R-HSA-3247509 Chromatin modifying enzymes 0.033747 1.472
R-HSA-6794361 Neurexins and neuroligins 0.035741 1.447
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.035741 1.447
R-HSA-68867 Assembly of the pre-replicative complex 0.035744 1.447
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.036390 1.439
R-HSA-9823730 Formation of definitive endoderm 0.036390 1.439
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.037240 1.429
R-HSA-193648 NRAGE signals death through JNK 0.041928 1.377
R-HSA-9819196 Zygotic genome activation (ZGA) 0.039059 1.408
R-HSA-209563 Axonal growth stimulation 0.057883 1.237
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 0.057883 1.237
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.057883 1.237
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.057883 1.237
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.050433 1.297
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.053955 1.268
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.053955 1.268
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.048617 1.313
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.056573 1.247
R-HSA-525793 Myogenesis 0.056512 1.248
R-HSA-9865118 Diseases of branched-chain amino acid catabolism 0.056512 1.248
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.046579 1.332
R-HSA-8875513 MET interacts with TNS proteins 0.057883 1.237
R-HSA-69306 DNA Replication 0.055247 1.258
R-HSA-1482801 Acyl chain remodelling of PS 0.053442 1.272
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 0.057883 1.237
R-HSA-1852241 Organelle biogenesis and maintenance 0.052466 1.280
R-HSA-4839726 Chromatin organization 0.043633 1.360
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.046899 1.329
R-HSA-69242 S Phase 0.049876 1.302
R-HSA-8874177 ATF6B (ATF6-beta) activates chaperones 0.046579 1.332
R-HSA-948021 Transport to the Golgi and subsequent modification 0.050416 1.297
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.055200 1.258
R-HSA-9700206 Signaling by ALK in cancer 0.055200 1.258
R-HSA-73887 Death Receptor Signaling 0.056360 1.249
R-HSA-445095 Interaction between L1 and Ankyrins 0.059643 1.224
R-HSA-8854518 AURKA Activation by TPX2 0.059562 1.225
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.067445 1.171
R-HSA-68962 Activation of the pre-replicative complex 0.069380 1.159
R-HSA-73863 RNA Polymerase I Transcription Termination 0.059643 1.224
R-HSA-69002 DNA Replication Pre-Initiation 0.057964 1.237
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.069486 1.158
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.069380 1.159
R-HSA-5693606 DNA Double Strand Break Response 0.061490 1.211
R-HSA-199991 Membrane Trafficking 0.058648 1.232
R-HSA-9730414 MITF-M-regulated melanocyte development 0.061830 1.209
R-HSA-176417 Phosphorylation of Emi1 0.091000 1.041
R-HSA-9865113 Loss-of-function mutations in DBT cause MSUD2 0.091000 1.041
R-HSA-9907570 Loss-of-function mutations in DLD cause MSUD3/DLDD 0.091000 1.041
R-HSA-9912529 H139Hfs13* PPM1K causes a mild variant of MSUD 0.101779 0.992
R-HSA-9912481 Branched-chain ketoacid dehydrogenase kinase deficiency 0.101779 0.992
R-HSA-9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 0.101779 0.992
R-HSA-111995 phospho-PLA2 pathway 0.122958 0.910
R-HSA-390450 Folding of actin by CCT/TriC 0.143640 0.843
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.153799 0.813
R-HSA-5358493 Synthesis of diphthamide-EEF2 0.163837 0.786
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.163837 0.786
R-HSA-9865114 Maple Syrup Urine Disease 0.173757 0.760
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.183560 0.736
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.193248 0.714
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.193248 0.714
R-HSA-69166 Removal of the Flap Intermediate 0.193248 0.714
R-HSA-9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 0.193248 0.714
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.202820 0.693
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.202820 0.693
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.083097 1.080
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.083097 1.080
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.212280 0.673
R-HSA-176412 Phosphorylation of the APC/C 0.212280 0.673
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.221629 0.654
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.230866 0.637
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.230866 0.637
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.105037 0.979
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.239995 0.620
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.108833 0.963
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.249016 0.604
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.257931 0.588
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.266740 0.574
R-HSA-774815 Nucleosome assembly 0.132320 0.878
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.132320 0.878
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.073652 1.133
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.136340 0.865
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.275445 0.560
R-HSA-380287 Centrosome maturation 0.077928 1.108
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.300949 0.522
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.165172 0.782
R-HSA-9932451 SWI/SNF chromatin remodelers 0.309250 0.510
R-HSA-9932444 ATP-dependent chromatin remodelers 0.309250 0.510
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.325559 0.487
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.349307 0.457
R-HSA-8957275 Post-translational protein phosphorylation 0.142253 0.847
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.081308 1.090
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.081308 1.090
R-HSA-453276 Regulation of mitotic cell cycle 0.242840 0.615
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.242840 0.615
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.291181 0.536
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.115748 0.936
R-HSA-69183 Processive synthesis on the lagging strand 0.202820 0.693
R-HSA-6783310 Fanconi Anemia Pathway 0.132320 0.878
R-HSA-390466 Chaperonin-mediated protein folding 0.317432 0.498
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.203574 0.691
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.090241 1.045
R-HSA-2424491 DAP12 signaling 0.349307 0.457
R-HSA-171319 Telomere Extension By Telomerase 0.333569 0.477
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.116122 0.935
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.292986 0.533
R-HSA-69186 Lagging Strand Synthesis 0.266740 0.574
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.286106 0.543
R-HSA-216083 Integrin cell surface interactions 0.273608 0.563
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.317453 0.498
R-HSA-180786 Extension of Telomeres 0.190646 0.720
R-HSA-73864 RNA Polymerase I Transcription 0.273608 0.563
R-HSA-212165 Epigenetic regulation of gene expression 0.117978 0.928
R-HSA-391251 Protein folding 0.343456 0.464
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.091382 1.039
R-HSA-73886 Chromosome Maintenance 0.079332 1.101
R-HSA-193697 p75NTR regulates axonogenesis 0.133361 0.875
R-HSA-209560 NF-kB is activated and signals survival 0.163837 0.786
R-HSA-9603798 Class I peroxisomal membrane protein import 0.212280 0.673
R-HSA-1566977 Fibronectin matrix formation 0.221629 0.654
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.221629 0.654
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.239995 0.620
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.292548 0.534
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.300949 0.522
R-HSA-1592230 Mitochondrial biogenesis 0.072873 1.137
R-HSA-8949613 Cristae formation 0.325559 0.487
R-HSA-8856688 Golgi-to-ER retrograde transport 0.259637 0.586
R-HSA-193639 p75NTR signals via NF-kB 0.202820 0.693
R-HSA-209543 p75NTR recruits signalling complexes 0.173757 0.760
R-HSA-156842 Eukaryotic Translation Elongation 0.343456 0.464
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.173597 0.760
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.317453 0.498
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.275445 0.560
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.249016 0.604
R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.122958 0.910
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.122958 0.910
R-HSA-1483226 Synthesis of PI 0.153799 0.813
R-HSA-1483115 Hydrolysis of LPC 0.193248 0.714
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.221629 0.654
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.098447 1.007
R-HSA-3000157 Laminin interactions 0.309250 0.510
R-HSA-420029 Tight junction interactions 0.309250 0.510
R-HSA-5689901 Metalloprotease DUBs 0.317453 0.498
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.317453 0.498
R-HSA-9664873 Pexophagy 0.143640 0.843
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.144460 0.840
R-HSA-8951664 Neddylation 0.324235 0.489
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.260415 0.584
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.122806 0.911
R-HSA-205043 NRIF signals cell death from the nucleus 0.193248 0.714
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.257931 0.588
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.165172 0.782
R-HSA-114608 Platelet degranulation 0.091297 1.040
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.291181 0.536
R-HSA-444821 Relaxin receptors 0.091000 1.041
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.112431 0.949
R-HSA-9683686 Maturation of spike protein 0.143640 0.843
R-HSA-69109 Leading Strand Synthesis 0.173757 0.760
R-HSA-69091 Polymerase switching 0.173757 0.760
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.173757 0.760
R-HSA-9694548 Maturation of spike protein 0.112665 0.948
R-HSA-68949 Orc1 removal from chromatin 0.160987 0.793
R-HSA-429947 Deadenylation of mRNA 0.300949 0.522
R-HSA-933542 TRAF6 mediated NF-kB activation 0.300949 0.522
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.169376 0.771
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.299951 0.523
R-HSA-70895 Branched-chain amino acid catabolism 0.156822 0.805
R-HSA-73893 DNA Damage Bypass 0.148558 0.828
R-HSA-176187 Activation of ATR in response to replication stress 0.079594 1.099
R-HSA-844456 The NLRP3 inflammasome 0.249016 0.604
R-HSA-5656169 Termination of translesion DNA synthesis 0.341485 0.467
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.132320 0.878
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.104070 0.983
R-HSA-9663891 Selective autophagy 0.321788 0.492
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.071556 1.145
R-HSA-76002 Platelet activation, signaling and aggregation 0.141272 0.850
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 0.266740 0.574
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 0.091000 1.041
R-HSA-447041 CHL1 interactions 0.112431 0.949
R-HSA-5336415 Uptake and function of diphtheria toxin 0.112431 0.949
R-HSA-9675126 Diseases of mitotic cell cycle 0.076139 1.118
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 0.257931 0.588
R-HSA-8874081 MET activates PTK2 signaling 0.317453 0.498
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.333569 0.477
R-HSA-73894 DNA Repair 0.086674 1.062
R-HSA-9758274 Regulation of NF-kappa B signaling 0.212280 0.673
R-HSA-3214858 RMTs methylate histone arginines 0.128327 0.892
R-HSA-6794362 Protein-protein interactions at synapses 0.100850 0.996
R-HSA-5617833 Cilium Assembly 0.239992 0.620
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.140387 0.853
R-HSA-3000178 ECM proteoglycans 0.242840 0.615
R-HSA-9675151 Disorders of Developmental Biology 0.221629 0.654
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.230866 0.637
R-HSA-1482922 Acyl chain remodelling of PI 0.257931 0.588
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.309250 0.510
R-HSA-69481 G2/M Checkpoints 0.091297 1.040
R-HSA-69473 G2/M DNA damage checkpoint 0.256019 0.592
R-HSA-69275 G2/M Transition 0.229821 0.639
R-HSA-5693532 DNA Double-Strand Break Repair 0.149011 0.827
R-HSA-453274 Mitotic G2-G2/M phases 0.234893 0.629
R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 0.080091 1.096
R-HSA-9830674 Formation of the ureteric bud 0.292548 0.534
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.300949 0.522
R-HSA-622312 Inflammasomes 0.333569 0.477
R-HSA-373760 L1CAM interactions 0.071301 1.147
R-HSA-5653656 Vesicle-mediated transport 0.192371 0.716
R-HSA-75892 Platelet Adhesion to exposed collagen 0.183560 0.736
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.212280 0.673
R-HSA-8852135 Protein ubiquitination 0.077928 1.108
R-HSA-3214842 HDMs demethylate histones 0.309250 0.510
R-HSA-5693607 Processing of DNA double-strand break ends 0.286792 0.542
R-HSA-416700 Other semaphorin interactions 0.202820 0.693
R-HSA-432142 Platelet sensitization by LDL 0.239995 0.620
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.349307 0.457
R-HSA-392499 Metabolism of proteins 0.179561 0.746
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.309833 0.509
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.122958 0.910
R-HSA-446353 Cell-extracellular matrix interactions 0.202820 0.693
R-HSA-210991 Basigin interactions 0.266740 0.574
R-HSA-1482925 Acyl chain remodelling of PG 0.266740 0.574
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.133975 0.873
R-HSA-597592 Post-translational protein modification 0.101288 0.994
R-HSA-445144 Signal transduction by L1 0.257931 0.588
R-HSA-1482798 Acyl chain remodeling of CL 0.193248 0.714
R-HSA-9671555 Signaling by PDGFR in disease 0.275445 0.560
R-HSA-446203 Asparagine N-linked glycosylation 0.278547 0.555
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.242840 0.615
R-HSA-8853884 Transcriptional Regulation by VENTX 0.112665 0.948
R-HSA-1538133 G0 and Early G1 0.076139 1.118
R-HSA-111471 Apoptotic factor-mediated response 0.239995 0.620
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.194251 0.712
R-HSA-9020702 Interleukin-1 signaling 0.150571 0.822
R-HSA-9637690 Response of Mtb to phagocytosis 0.124365 0.905
R-HSA-416482 G alpha (12/13) signalling events 0.084539 1.073
R-HSA-3000170 Syndecan interactions 0.292548 0.534
R-HSA-9694635 Translation of Structural Proteins 0.269211 0.570
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.191244 0.718
R-HSA-381119 Unfolded Protein Response (UPR) 0.117613 0.930
R-HSA-5693538 Homology Directed Repair 0.209458 0.679
R-HSA-373755 Semaphorin interactions 0.207906 0.682
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.343456 0.464
R-HSA-446652 Interleukin-1 family signaling 0.330654 0.481
R-HSA-381070 IRE1alpha activates chaperones 0.120889 0.918
R-HSA-381038 XBP1(S) activates chaperone genes 0.313070 0.504
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.351545 0.454
R-HSA-9837999 Mitochondrial protein degradation 0.352064 0.453
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.357037 0.447
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.357037 0.447
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.357037 0.447
R-HSA-2129379 Molecules associated with elastic fibres 0.357037 0.447
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.364675 0.438
R-HSA-157579 Telomere Maintenance 0.369160 0.433
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.369160 0.433
R-HSA-1855170 IPs transport between nucleus and cytosol 0.372223 0.429
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.372223 0.429
R-HSA-354192 Integrin signaling 0.372223 0.429
R-HSA-1839124 FGFR1 mutant receptor activation 0.372223 0.429
R-HSA-9930044 Nuclear RNA decay 0.372223 0.429
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.372223 0.429
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.372223 0.429
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.373407 0.428
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.373407 0.428
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.373407 0.428
R-HSA-390522 Striated Muscle Contraction 0.379682 0.421
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.379682 0.421
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.379682 0.421
R-HSA-1482788 Acyl chain remodelling of PC 0.379682 0.421
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.379682 0.421
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.387053 0.412
R-HSA-5696400 Dual Incision in GG-NER 0.387053 0.412
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.387053 0.412
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.387053 0.412
R-HSA-180746 Nuclear import of Rev protein 0.387053 0.412
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.387053 0.412
R-HSA-5205647 Mitophagy 0.387053 0.412
R-HSA-901042 Calnexin/calreticulin cycle 0.387053 0.412
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.387053 0.412
R-HSA-392518 Signal amplification 0.387053 0.412
R-HSA-9842860 Regulation of endogenous retroelements 0.390277 0.409
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.390277 0.409
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.394336 0.404
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.394336 0.404
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.394336 0.404
R-HSA-1482839 Acyl chain remodelling of PE 0.394336 0.404
R-HSA-381042 PERK regulates gene expression 0.394336 0.404
R-HSA-9860931 Response of endothelial cells to shear stress 0.398637 0.399
R-HSA-432720 Lysosome Vesicle Biogenesis 0.401534 0.396
R-HSA-9682385 FLT3 signaling in disease 0.401534 0.396
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.401534 0.396
R-HSA-114604 GPVI-mediated activation cascade 0.401534 0.396
R-HSA-5619507 Activation of HOX genes during differentiation 0.402798 0.395
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.402798 0.395
R-HSA-5696398 Nucleotide Excision Repair 0.406944 0.390
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.406944 0.390
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.408646 0.389
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.408646 0.389
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.408646 0.389
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.415674 0.381
R-HSA-1566948 Elastic fibre formation 0.415674 0.381
R-HSA-8875878 MET promotes cell motility 0.415674 0.381
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.419300 0.377
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.419300 0.377
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.422620 0.374
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.422620 0.374
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.422620 0.374
R-HSA-9648002 RAS processing 0.422620 0.374
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.423390 0.373
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.427465 0.369
R-HSA-166166 MyD88-independent TLR4 cascade 0.427465 0.369
R-HSA-202433 Generation of second messenger molecules 0.429483 0.367
R-HSA-9646399 Aggrephagy 0.429483 0.367
R-HSA-177243 Interactions of Rev with host cellular proteins 0.429483 0.367
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.429483 0.367
R-HSA-379726 Mitochondrial tRNA aminoacylation 0.429483 0.367
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.435570 0.361
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.435570 0.361
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.436265 0.360
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.436265 0.360
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.436265 0.360
R-HSA-9734767 Developmental Cell Lineages 0.436737 0.360
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.439600 0.357
R-HSA-5674135 MAP2K and MAPK activation 0.442966 0.354
R-HSA-9656223 Signaling by RAF1 mutants 0.442966 0.354
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.442966 0.354
R-HSA-5655302 Signaling by FGFR1 in disease 0.442966 0.354
R-HSA-6811438 Intra-Golgi traffic 0.442966 0.354
R-HSA-9683701 Translation of Structural Proteins 0.442966 0.354
R-HSA-9855142 Cellular responses to mechanical stimuli 0.443613 0.353
R-HSA-72766 Translation 0.448784 0.348
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.449589 0.347
R-HSA-111996 Ca-dependent events 0.449589 0.347
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.451593 0.345
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.456133 0.341
R-HSA-72737 Cap-dependent Translation Initiation 0.459508 0.338
R-HSA-72613 Eukaryotic Translation Initiation 0.459508 0.338
R-HSA-2172127 DAP12 interactions 0.462600 0.335
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.462600 0.335
R-HSA-72163 mRNA Splicing - Major Pathway 0.467231 0.330
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.468990 0.329
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.468990 0.329
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.471256 0.327
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.471256 0.327
R-HSA-9609690 HCMV Early Events 0.473327 0.325
R-HSA-68875 Mitotic Prophase 0.475138 0.323
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.475304 0.323
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.475304 0.323
R-HSA-9649948 Signaling downstream of RAS mutants 0.475304 0.323
R-HSA-6802949 Signaling by RAS mutants 0.475304 0.323
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.475304 0.323
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.475304 0.323
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.475304 0.323
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.475304 0.323
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.475304 0.323
R-HSA-9675135 Diseases of DNA repair 0.475304 0.323
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.475304 0.323
R-HSA-75153 Apoptotic execution phase 0.475304 0.323
R-HSA-3371556 Cellular response to heat stress 0.479003 0.320
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.479003 0.320
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.479003 0.320
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.481544 0.317
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.481544 0.317
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.482850 0.316
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.482850 0.316
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.486680 0.313
R-HSA-9634597 GPER1 signaling 0.487710 0.312
R-HSA-9766229 Degradation of CDH1 0.493804 0.306
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.493804 0.306
R-HSA-1483206 Glycerophospholipid biosynthesis 0.494409 0.306
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.498065 0.303
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.498065 0.303
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.498065 0.303
R-HSA-69206 G1/S Transition 0.498065 0.303
R-HSA-72172 mRNA Splicing 0.500357 0.301
R-HSA-5673001 RAF/MAP kinase cascade 0.503949 0.298
R-HSA-1169091 Activation of NF-kappaB in B cells 0.505774 0.296
R-HSA-2514856 The phototransduction cascade 0.505774 0.296
R-HSA-72187 mRNA 3'-end processing 0.511654 0.291
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.511654 0.291
R-HSA-73772 RNA Polymerase I Promoter Escape 0.511654 0.291
R-HSA-112382 Formation of RNA Pol II elongation complex 0.511654 0.291
R-HSA-5339562 Uptake and actions of bacterial toxins 0.511654 0.291
R-HSA-422475 Axon guidance 0.514255 0.289
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.517464 0.286
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.517464 0.286
R-HSA-445355 Smooth Muscle Contraction 0.517464 0.286
R-HSA-5684996 MAPK1/MAPK3 signaling 0.521462 0.283
R-HSA-72649 Translation initiation complex formation 0.523205 0.281
R-HSA-1474228 Degradation of the extracellular matrix 0.527627 0.278
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.528878 0.277
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.534484 0.272
R-HSA-72702 Ribosomal scanning and start codon recognition 0.534484 0.272
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.534484 0.272
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.534484 0.272
R-HSA-9764561 Regulation of CDH1 Function 0.540023 0.268
R-HSA-2980766 Nuclear Envelope Breakdown 0.540023 0.268
R-HSA-1483166 Synthesis of PA 0.540023 0.268
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.545497 0.263
R-HSA-6782135 Dual incision in TC-NER 0.545497 0.263
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.545497 0.263
R-HSA-9033241 Peroxisomal protein import 0.550906 0.259
R-HSA-191859 snRNP Assembly 0.550906 0.259
R-HSA-194441 Metabolism of non-coding RNA 0.550906 0.259
R-HSA-429914 Deadenylation-dependent mRNA decay 0.550906 0.259
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.556252 0.255
R-HSA-379724 tRNA Aminoacylation 0.556252 0.255
R-HSA-73856 RNA Polymerase II Transcription Termination 0.561533 0.251
R-HSA-168325 Viral Messenger RNA Synthesis 0.561533 0.251
R-HSA-112043 PLC beta mediated events 0.561533 0.251
R-HSA-1632852 Macroautophagy 0.562898 0.250
R-HSA-375165 NCAM signaling for neurite out-growth 0.566753 0.247
R-HSA-6784531 tRNA processing in the nucleus 0.566753 0.247
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.566753 0.247
R-HSA-9707616 Heme signaling 0.566753 0.247
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.569724 0.244
R-HSA-8953854 Metabolism of RNA 0.571648 0.243
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.571910 0.243
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.571910 0.243
R-HSA-8848021 Signaling by PTK6 0.571910 0.243
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.571910 0.243
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.577007 0.239
R-HSA-9675108 Nervous system development 0.581452 0.235
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.582043 0.235
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.587019 0.231
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.589738 0.229
R-HSA-112040 G-protein mediated events 0.591936 0.228
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.591936 0.228
R-HSA-9830369 Kidney development 0.591936 0.228
R-HSA-9758941 Gastrulation 0.593007 0.227
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.596796 0.224
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.596796 0.224
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.599485 0.222
R-HSA-1474244 Extracellular matrix organization 0.604255 0.219
R-HSA-9609507 Protein localization 0.605886 0.218
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.606342 0.217
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.606342 0.217
R-HSA-204005 COPII-mediated vesicle transport 0.606342 0.217
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.609057 0.215
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.609057 0.215
R-HSA-427413 NoRC negatively regulates rRNA expression 0.611031 0.214
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.611031 0.214
R-HSA-9612973 Autophagy 0.615342 0.211
R-HSA-5578749 Transcriptional regulation by small RNAs 0.615663 0.211
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.615663 0.211
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.620242 0.207
R-HSA-1280218 Adaptive Immune System 0.624324 0.205
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.624765 0.204
R-HSA-1226099 Signaling by FGFR in disease 0.624765 0.204
R-HSA-109582 Hemostasis 0.625166 0.204
R-HSA-9609646 HCMV Infection 0.626241 0.203
R-HSA-9006936 Signaling by TGFB family members 0.627681 0.202
R-HSA-1169408 ISG15 antiviral mechanism 0.629236 0.201
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.629236 0.201
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.633653 0.198
R-HSA-109581 Apoptosis 0.633735 0.198
R-HSA-5683057 MAPK family signaling cascades 0.639111 0.194
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.642331 0.192
R-HSA-9694516 SARS-CoV-2 Infection 0.643326 0.192
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.646593 0.189
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.650804 0.187
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.650804 0.187
R-HSA-9833482 PKR-mediated signaling 0.650804 0.187
R-HSA-6806834 Signaling by MET 0.650804 0.187
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.650804 0.187
R-HSA-977225 Amyloid fiber formation 0.654966 0.184
R-HSA-1266738 Developmental Biology 0.659060 0.181
R-HSA-418555 G alpha (s) signalling events 0.662858 0.179
R-HSA-9707564 Cytoprotection by HMOX1 0.663142 0.178
R-HSA-9711123 Cellular response to chemical stress 0.669213 0.174
R-HSA-6802957 Oncogenic MAPK signaling 0.671125 0.173
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.675045 0.171
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.678919 0.168
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.678919 0.168
R-HSA-156902 Peptide chain elongation 0.686530 0.163
R-HSA-2559583 Cellular Senescence 0.687460 0.163
R-HSA-73884 Base Excision Repair 0.693962 0.159
R-HSA-162582 Signal Transduction 0.695537 0.158
R-HSA-2262752 Cellular responses to stress 0.699937 0.155
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.701218 0.154
R-HSA-375276 Peptide ligand-binding receptors 0.703034 0.153
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.715221 0.146
R-HSA-168898 Toll-like Receptor Cascades 0.715517 0.145
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.717961 0.144
R-HSA-72764 Eukaryotic Translation Termination 0.718618 0.144
R-HSA-72689 Formation of a pool of free 40S subunits 0.718618 0.144
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.721975 0.141
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.721975 0.141
R-HSA-9824439 Bacterial Infection Pathways 0.724306 0.140
R-HSA-1483257 Phospholipid metabolism 0.726751 0.139
R-HSA-3214847 HATs acetylate histones 0.731809 0.136
R-HSA-70171 Glycolysis 0.735010 0.134
R-HSA-8953897 Cellular responses to stimuli 0.741067 0.130
R-HSA-376176 Signaling by ROBO receptors 0.743695 0.129
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.747437 0.126
R-HSA-111885 Opioid Signalling 0.747437 0.126
R-HSA-5357801 Programmed Cell Death 0.750357 0.125
R-HSA-418346 Platelet homeostasis 0.756374 0.121
R-HSA-211000 Gene Silencing by RNA 0.759283 0.120
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.762158 0.118
R-HSA-397014 Muscle contraction 0.765329 0.116
R-HSA-202403 TCR signaling 0.767804 0.115
R-HSA-2871796 FCERI mediated MAPK activation 0.773317 0.112
R-HSA-1483249 Inositol phosphate metabolism 0.773317 0.112
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.786537 0.104
R-HSA-9007101 Rab regulation of trafficking 0.791608 0.101
R-HSA-70326 Glucose metabolism 0.791608 0.101
R-HSA-8878171 Transcriptional regulation by RUNX1 0.792955 0.101
R-HSA-9705683 SARS-CoV-2-host interactions 0.796659 0.099
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.798490 0.098
R-HSA-2132295 MHC class II antigen presentation 0.806112 0.094
R-HSA-162909 Host Interactions of HIV factors 0.808429 0.092
R-HSA-9679506 SARS-CoV Infections 0.819619 0.086
R-HSA-9843745 Adipogenesis 0.828087 0.082
R-HSA-9909396 Circadian clock 0.830143 0.081
R-HSA-9018519 Estrogen-dependent gene expression 0.840063 0.076
R-HSA-388396 GPCR downstream signalling 0.840175 0.076
R-HSA-5688426 Deubiquitination 0.841229 0.075
R-HSA-9664407 Parasite infection 0.847583 0.072
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.847583 0.072
R-HSA-9664417 Leishmania phagocytosis 0.847583 0.072
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.849407 0.071
R-HSA-162599 Late Phase of HIV Life Cycle 0.852991 0.069
R-HSA-8856828 Clathrin-mediated endocytosis 0.854751 0.068
R-HSA-2187338 Visual phototransduction 0.861583 0.065
R-HSA-913531 Interferon Signaling 0.862403 0.064
R-HSA-9679191 Potential therapeutics for SARS 0.866496 0.062
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.869675 0.061
R-HSA-2142753 Arachidonate metabolism 0.869675 0.061
R-HSA-1989781 PPARA activates gene expression 0.874303 0.058
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.874303 0.058
R-HSA-9824443 Parasitic Infection Pathways 0.875623 0.058
R-HSA-9658195 Leishmania infection 0.875623 0.058
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.877297 0.057
R-HSA-9610379 HCMV Late Events 0.877297 0.057
R-HSA-162587 HIV Life Cycle 0.877297 0.057
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.878767 0.056
R-HSA-449147 Signaling by Interleukins 0.886983 0.052
R-HSA-5619102 SLC transporter disorders 0.891235 0.050
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.896359 0.048
R-HSA-72306 tRNA processing 0.896359 0.048
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.898830 0.046
R-HSA-5689880 Ub-specific processing proteases 0.900043 0.046
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.901242 0.045
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.902427 0.045
R-HSA-9678108 SARS-CoV-1 Infection 0.902427 0.045
R-HSA-372790 Signaling by GPCR 0.903150 0.044
R-HSA-168255 Influenza Infection 0.907026 0.042
R-HSA-201681 TCF dependent signaling in response to WNT 0.911409 0.040
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.916600 0.038
R-HSA-1643685 Disease 0.926067 0.033
R-HSA-6798695 Neutrophil degranulation 0.926182 0.033
R-HSA-389948 Co-inhibition by PD-1 0.927857 0.033
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.930427 0.031
R-HSA-112316 Neuronal System 0.932933 0.030
R-HSA-162906 HIV Infection 0.948587 0.023
R-HSA-72312 rRNA processing 0.951608 0.022
R-HSA-1280215 Cytokine Signaling in Immune system 0.953166 0.021
R-HSA-202733 Cell surface interactions at the vascular wall 0.954452 0.020
R-HSA-8939211 ESR-mediated signaling 0.954452 0.020
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.959570 0.018
R-HSA-5619115 Disorders of transmembrane transporters 0.959651 0.018
R-HSA-388841 Regulation of T cell activation by CD28 family 0.963823 0.016
R-HSA-418594 G alpha (i) signalling events 0.964592 0.016
R-HSA-416476 G alpha (q) signalling events 0.967170 0.014
R-HSA-5668914 Diseases of metabolism 0.971171 0.013
R-HSA-168256 Immune System 0.973180 0.012
R-HSA-195721 Signaling by WNT 0.978280 0.010
R-HSA-74160 Gene expression (Transcription) 0.983424 0.007
R-HSA-8957322 Metabolism of steroids 0.984173 0.007
R-HSA-5663205 Infectious disease 0.986784 0.006
R-HSA-9006931 Signaling by Nuclear Receptors 0.990165 0.004
R-HSA-168249 Innate Immune System 0.992616 0.003
R-HSA-8978868 Fatty acid metabolism 0.994328 0.002
R-HSA-9824446 Viral Infection Pathways 0.994519 0.002
R-HSA-500792 GPCR ligand binding 0.994843 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 0.996244 0.002
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.996852 0.001
R-HSA-3700989 Transcriptional Regulation by TP53 0.997216 0.001
R-HSA-73857 RNA Polymerase II Transcription 0.999005 0.000
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.999553 0.000
R-HSA-212436 Generic Transcription Pathway 0.999893 0.000
R-HSA-556833 Metabolism of lipids 0.999991 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CK2A2CK2A2 0.810 0.585 1 0.809
CK2A1CK2A1 0.798 0.536 1 0.787
COTCOT 0.796 0.125 2 0.856
FAM20CFAM20C 0.789 0.162 2 0.621
GRK7GRK7 0.787 0.372 1 0.775
GRK6GRK6 0.785 0.340 1 0.848
IKKAIKKA 0.785 0.208 -2 0.763
BMPR1BBMPR1B 0.783 0.237 1 0.835
GRK1GRK1 0.783 0.199 -2 0.785
CLK3CLK3 0.783 0.061 1 0.826
DSTYKDSTYK 0.781 0.090 2 0.870
IKKBIKKB 0.780 0.109 -2 0.758
CAMK2GCAMK2G 0.780 0.186 2 0.838
MOSMOS 0.780 0.101 1 0.906
CDC7CDC7 0.780 0.038 1 0.882
TGFBR1TGFBR1 0.779 0.267 -2 0.900
PIM3PIM3 0.776 0.056 -3 0.792
NDR2NDR2 0.775 0.032 -3 0.799
CAMK2BCAMK2B 0.774 0.191 2 0.835
BMPR1ABMPR1A 0.774 0.231 1 0.817
ALK2ALK2 0.773 0.263 -2 0.897
PRPKPRPK 0.772 -0.026 -1 0.806
RAF1RAF1 0.772 -0.037 1 0.824
GRK4GRK4 0.771 0.115 -2 0.841
GRK5GRK5 0.771 0.135 -3 0.813
GCN2GCN2 0.768 -0.080 2 0.795
PIM1PIM1 0.768 0.063 -3 0.753
ALK4ALK4 0.768 0.200 -2 0.912
BMPR2BMPR2 0.768 -0.001 -2 0.885
TBK1TBK1 0.767 -0.040 1 0.716
ATMATM 0.767 0.081 1 0.757
ACVR2AACVR2A 0.767 0.188 -2 0.863
MAPKAPK2MAPKAPK2 0.767 0.107 -3 0.698
ACVR2BACVR2B 0.766 0.173 -2 0.874
NEK6NEK6 0.765 -0.025 -2 0.867
PDHK4PDHK4 0.765 -0.104 1 0.840
ATRATR 0.765 0.017 1 0.823
KISKIS 0.764 -0.005 1 0.683
IKKEIKKE 0.764 -0.039 1 0.710
CAMK1BCAMK1B 0.764 -0.018 -3 0.808
CAMK2ACAMK2A 0.764 0.146 2 0.843
NEK7NEK7 0.764 -0.050 -3 0.771
PLK3PLK3 0.764 0.197 2 0.747
MTORMTOR 0.763 -0.061 1 0.769
PLK1PLK1 0.763 0.147 -2 0.843
LATS2LATS2 0.763 0.045 -5 0.663
TGFBR2TGFBR2 0.762 0.005 -2 0.867
ERK5ERK5 0.762 -0.008 1 0.812
ULK2ULK2 0.762 -0.090 2 0.761
RSK2RSK2 0.762 0.032 -3 0.724
CDKL1CDKL1 0.760 -0.022 -3 0.742
HUNKHUNK 0.759 -0.042 2 0.748
MARK4MARK4 0.759 -0.028 4 0.815
PDHK1PDHK1 0.758 -0.079 1 0.822
MLK1MLK1 0.758 -0.074 2 0.789
NLKNLK 0.758 -0.080 1 0.812
PRKD1PRKD1 0.758 -0.019 -3 0.762
SKMLCKSKMLCK 0.758 -0.042 -2 0.799
PKN3PKN3 0.757 -0.035 -3 0.764
NDR1NDR1 0.757 -0.054 -3 0.790
NUAK2NUAK2 0.756 -0.056 -3 0.797
SRPK1SRPK1 0.755 -0.027 -3 0.702
TLK2TLK2 0.755 0.097 1 0.790
CAMK2DCAMK2D 0.755 0.032 -3 0.768
MST4MST4 0.755 -0.066 2 0.832
NIKNIK 0.754 -0.104 -3 0.825
RIPK3RIPK3 0.754 -0.183 3 0.130
CAMLCKCAMLCK 0.754 -0.058 -2 0.801
LATS1LATS1 0.754 0.064 -3 0.809
DLKDLK 0.754 -0.039 1 0.829
AMPKA1AMPKA1 0.753 -0.037 -3 0.805
GRK2GRK2 0.753 0.059 -2 0.767
ULK1ULK1 0.753 -0.090 -3 0.753
P90RSKP90RSK 0.752 -0.018 -3 0.719
BCKDKBCKDK 0.751 -0.063 -1 0.773
PKCDPKCD 0.751 -0.042 2 0.781
DAPK2DAPK2 0.751 -0.070 -3 0.802
CDKL5CDKL5 0.751 -0.036 -3 0.730
WNK1WNK1 0.751 -0.101 -2 0.804
CDK8CDK8 0.750 -0.007 1 0.669
MAPKAPK3MAPKAPK3 0.750 0.005 -3 0.726
PRKD2PRKD2 0.750 -0.030 -3 0.728
RSK4RSK4 0.750 0.037 -3 0.700
SRPK2SRPK2 0.750 -0.022 -3 0.627
TSSK2TSSK2 0.749 -0.035 -5 0.706
P70S6KBP70S6KB 0.749 -0.033 -3 0.745
CLK2CLK2 0.749 0.030 -3 0.717
BRAFBRAF 0.748 0.052 -4 0.829
ICKICK 0.748 -0.032 -3 0.778
MLK4MLK4 0.748 -0.030 2 0.709
GRK3GRK3 0.748 0.094 -2 0.737
PRKXPRKX 0.748 0.053 -3 0.659
AMPKA2AMPKA2 0.747 -0.046 -3 0.776
JNK3JNK3 0.747 0.049 1 0.643
MSK2MSK2 0.747 -0.010 -3 0.689
ANKRD3ANKRD3 0.747 -0.135 1 0.836
DNAPKDNAPK 0.747 0.060 1 0.662
CHAK2CHAK2 0.747 -0.124 -1 0.779
PLK2PLK2 0.747 0.146 -3 0.798
WNK3WNK3 0.746 -0.180 1 0.792
NIM1NIM1 0.746 -0.100 3 0.164
SRPK3SRPK3 0.746 -0.041 -3 0.672
TSSK1TSSK1 0.746 -0.052 -3 0.819
HIPK4HIPK4 0.746 -0.066 1 0.767
MASTLMASTL 0.745 -0.192 -2 0.780
NEK9NEK9 0.745 -0.149 2 0.814
TTBK2TTBK2 0.745 -0.047 2 0.650
GSK3AGSK3A 0.745 0.077 4 0.505
CDK1CDK1 0.745 -0.015 1 0.629
MARK2MARK2 0.744 -0.011 4 0.728
PKACGPKACG 0.744 -0.039 -2 0.669
MEK1MEK1 0.744 -0.057 2 0.804
PKACBPKACB 0.744 0.015 -2 0.605
PAK1PAK1 0.744 -0.025 -2 0.721
MLK3MLK3 0.743 -0.073 2 0.725
RSK3RSK3 0.743 -0.051 -3 0.713
PKRPKR 0.743 -0.078 1 0.823
JNK2JNK2 0.743 0.036 1 0.603
QSKQSK 0.743 -0.052 4 0.788
PKN2PKN2 0.743 -0.108 -3 0.788
MSK1MSK1 0.743 0.009 -3 0.696
BRSK1BRSK1 0.742 -0.035 -3 0.740
IRE2IRE2 0.742 -0.129 2 0.733
CHK1CHK1 0.742 -0.008 -3 0.786
MARK3MARK3 0.742 -0.021 4 0.759
CDK2CDK2 0.741 -0.058 1 0.713
TLK1TLK1 0.741 0.025 -2 0.884
NUAK1NUAK1 0.741 -0.074 -3 0.747
AURCAURC 0.741 -0.033 -2 0.588
MLK2MLK2 0.740 -0.174 2 0.802
CDK19CDK19 0.740 -0.024 1 0.628
SIKSIK 0.740 -0.055 -3 0.714
CDK5CDK5 0.740 -0.045 1 0.690
CLK4CLK4 0.740 -0.018 -3 0.728
YSK4YSK4 0.739 -0.086 1 0.760
DYRK2DYRK2 0.739 -0.022 1 0.688
PASKPASK 0.738 0.023 -3 0.801
CDK3CDK3 0.737 -0.020 1 0.570
AURAAURA 0.737 -0.009 -2 0.578
MEKK3MEKK3 0.737 -0.075 1 0.791
CAMK4CAMK4 0.737 -0.100 -3 0.773
IRE1IRE1 0.737 -0.172 1 0.773
CK1ECK1E 0.737 -0.001 -3 0.593
PKCBPKCB 0.737 -0.071 2 0.724
RIPK1RIPK1 0.737 -0.235 1 0.782
DRAK1DRAK1 0.736 -0.035 1 0.763
CLK1CLK1 0.735 -0.027 -3 0.706
MARK1MARK1 0.735 -0.045 4 0.776
P38BP38B 0.735 0.009 1 0.629
SMG1SMG1 0.735 -0.038 1 0.771
MYLK4MYLK4 0.735 -0.054 -2 0.708
ERK1ERK1 0.735 -0.010 1 0.612
P38GP38G 0.734 0.009 1 0.539
VRK2VRK2 0.734 -0.253 1 0.864
P38AP38A 0.734 -0.020 1 0.695
PAK3PAK3 0.733 -0.094 -2 0.719
CDK7CDK7 0.733 -0.061 1 0.671
PIM2PIM2 0.733 -0.022 -3 0.696
MEKK2MEKK2 0.733 -0.098 2 0.788
PKCGPKCG 0.732 -0.086 2 0.711
PLK4PLK4 0.732 -0.069 2 0.571
PERKPERK 0.732 -0.096 -2 0.852
GSK3BGSK3B 0.732 0.009 4 0.493
JNK1JNK1 0.732 0.028 1 0.601
PAK2PAK2 0.732 -0.069 -2 0.707
QIKQIK 0.732 -0.140 -3 0.762
CK1G1CK1G1 0.732 -0.020 -3 0.594
ERK2ERK2 0.732 -0.030 1 0.650
AURBAURB 0.731 -0.050 -2 0.590
GAKGAK 0.731 0.052 1 0.868
CDK18CDK18 0.731 -0.037 1 0.600
MEKK1MEKK1 0.731 -0.135 1 0.803
MELKMELK 0.731 -0.122 -3 0.750
CDK13CDK13 0.730 -0.059 1 0.637
PKCAPKCA 0.730 -0.086 2 0.718
PRKD3PRKD3 0.730 -0.074 -3 0.695
MNK2MNK2 0.730 -0.100 -2 0.721
NEK2NEK2 0.729 -0.110 2 0.779
HIPK2HIPK2 0.729 -0.016 1 0.599
TAO3TAO3 0.729 -0.062 1 0.780
PKCHPKCH 0.729 -0.096 2 0.705
DCAMKL1DCAMKL1 0.729 -0.042 -3 0.753
BRSK2BRSK2 0.729 -0.107 -3 0.757
ZAKZAK 0.729 -0.118 1 0.773
CK1DCK1D 0.728 0.004 -3 0.544
HRIHRI 0.727 -0.155 -2 0.859
CDK17CDK17 0.727 -0.039 1 0.548
PINK1PINK1 0.727 -0.113 1 0.823
SGK3SGK3 0.727 -0.033 -3 0.713
PKCZPKCZ 0.727 -0.130 2 0.757
P38DP38D 0.727 0.019 1 0.558
MAPKAPK5MAPKAPK5 0.726 -0.096 -3 0.646
PAK6PAK6 0.726 -0.033 -2 0.639
MNK1MNK1 0.726 -0.096 -2 0.732
MEK5MEK5 0.726 -0.217 2 0.795
HIPK1HIPK1 0.726 -0.040 1 0.705
CK1A2CK1A2 0.726 -0.008 -3 0.545
PKACAPKACA 0.725 -0.006 -2 0.549
NEK5NEK5 0.725 -0.153 1 0.812
PHKG1PHKG1 0.725 -0.143 -3 0.776
CHAK1CHAK1 0.725 -0.204 2 0.720
DYRK4DYRK4 0.725 -0.005 1 0.618
AKT2AKT2 0.724 -0.047 -3 0.647
PRP4PRP4 0.724 -0.054 -3 0.683
CDK16CDK16 0.724 -0.023 1 0.567
PKG2PKG2 0.723 -0.061 -2 0.599
MST2MST2 0.723 -0.037 1 0.797
SSTKSSTK 0.722 -0.075 4 0.769
DAPK3DAPK3 0.722 -0.027 -3 0.756
EEF2KEEF2K 0.722 -0.057 3 0.167
CAMK1GCAMK1G 0.722 -0.082 -3 0.705
CAMKK1CAMKK1 0.722 -0.079 -2 0.728
WNK4WNK4 0.722 -0.162 -2 0.798
CAMK1DCAMK1D 0.721 -0.017 -3 0.642
CDK12CDK12 0.721 -0.061 1 0.606
SMMLCKSMMLCK 0.721 -0.083 -3 0.754
MST3MST3 0.721 -0.118 2 0.796
DYRK1BDYRK1B 0.721 -0.022 1 0.648
DYRK1ADYRK1A 0.721 -0.047 1 0.716
SNRKSNRK 0.720 -0.202 2 0.635
CDK9CDK9 0.720 -0.076 1 0.639
PDHK3_TYRPDHK3_TYR 0.720 0.238 4 0.870
NEK8NEK8 0.718 -0.150 2 0.783
CAMKK2CAMKK2 0.717 -0.078 -2 0.713
DAPK1DAPK1 0.717 -0.025 -3 0.734
MPSK1MPSK1 0.716 -0.076 1 0.804
DCAMKL2DCAMKL2 0.716 -0.080 -3 0.769
IRAK4IRAK4 0.716 -0.210 1 0.769
P70S6KP70S6K 0.715 -0.071 -3 0.649
TAK1TAK1 0.715 -0.049 1 0.806
AKT1AKT1 0.715 -0.048 -3 0.665
TTBK1TTBK1 0.715 -0.092 2 0.563
PDHK4_TYRPDHK4_TYR 0.714 0.198 2 0.867
PKCTPKCT 0.714 -0.116 2 0.721
TAO2TAO2 0.714 -0.139 2 0.825
ERK7ERK7 0.714 -0.021 2 0.542
GCKGCK 0.713 -0.108 1 0.780
MAP2K6_TYRMAP2K6_TYR 0.713 0.171 -1 0.836
HIPK3HIPK3 0.712 -0.082 1 0.689
CDK14CDK14 0.712 -0.069 1 0.640
DYRK3DYRK3 0.711 -0.048 1 0.706
LKB1LKB1 0.711 -0.132 -3 0.746
TNIKTNIK 0.711 -0.112 3 0.142
IRAK1IRAK1 0.711 -0.233 -1 0.690
TTKTTK 0.711 -0.031 -2 0.853
PDHK1_TYRPDHK1_TYR 0.710 0.161 -1 0.840
NEK11NEK11 0.710 -0.212 1 0.767
PHKG2PHKG2 0.709 -0.140 -3 0.752
PAK5PAK5 0.709 -0.057 -2 0.578
MST1MST1 0.708 -0.097 1 0.771
MAP2K4_TYRMAP2K4_TYR 0.708 0.089 -1 0.838
MINKMINK 0.708 -0.149 1 0.764
HGKHGK 0.707 -0.153 3 0.136
CDK10CDK10 0.707 -0.062 1 0.624
SGK1SGK1 0.707 -0.014 -3 0.575
MAKMAK 0.706 -0.007 -2 0.688
PDK1PDK1 0.706 -0.143 1 0.755
NEK4NEK4 0.706 -0.207 1 0.760
PAK4PAK4 0.706 -0.059 -2 0.587
SBKSBK 0.705 0.002 -3 0.540
ALPHAK3ALPHAK3 0.705 0.033 -1 0.746
OSR1OSR1 0.705 -0.054 2 0.783
PKCIPKCI 0.705 -0.134 2 0.724
BMPR2_TYRBMPR2_TYR 0.705 0.049 -1 0.827
MAP3K15MAP3K15 0.704 -0.182 1 0.749
PKCEPKCE 0.704 -0.094 2 0.695
CDK6CDK6 0.704 -0.068 1 0.615
VRK1VRK1 0.703 -0.204 2 0.803
MRCKAMRCKA 0.702 -0.052 -3 0.710
CDK4CDK4 0.702 -0.064 1 0.596
MEKK6MEKK6 0.702 -0.211 1 0.790
MAP2K7_TYRMAP2K7_TYR 0.701 0.011 2 0.829
CAMK1ACAMK1A 0.701 -0.057 -3 0.624
LRRK2LRRK2 0.701 -0.204 2 0.809
ROCK2ROCK2 0.701 -0.058 -3 0.744
TESK1_TYRTESK1_TYR 0.701 -0.086 3 0.200
TXKTXK 0.701 0.034 1 0.885
HPK1HPK1 0.701 -0.147 1 0.752
MRCKBMRCKB 0.700 -0.054 -3 0.690
AKT3AKT3 0.700 -0.050 -3 0.592
CK1ACK1A 0.700 -0.005 -3 0.471
KHS2KHS2 0.700 -0.113 1 0.755
CHK2CHK2 0.699 -0.077 -3 0.600
KHS1KHS1 0.699 -0.133 1 0.745
NEK1NEK1 0.699 -0.203 1 0.774
INSRRINSRR 0.699 -0.046 3 0.144
DMPK1DMPK1 0.698 -0.032 -3 0.728
MOKMOK 0.698 -0.042 1 0.723
MEK2MEK2 0.698 -0.189 2 0.777
PKMYT1_TYRPKMYT1_TYR 0.698 -0.142 3 0.180
SLKSLK 0.697 -0.120 -2 0.670
PINK1_TYRPINK1_TYR 0.697 -0.090 1 0.835
RIPK2RIPK2 0.697 -0.226 1 0.724
YES1YES1 0.696 -0.033 -1 0.752
EPHA6EPHA6 0.696 -0.041 -1 0.822
YSK1YSK1 0.696 -0.154 2 0.789
BUB1BUB1 0.695 -0.082 -5 0.684
LOKLOK 0.695 -0.167 -2 0.708
FERFER 0.695 -0.043 1 0.886
PBKPBK 0.695 -0.058 1 0.806
EPHB4EPHB4 0.694 -0.065 -1 0.800
PKN1PKN1 0.694 -0.113 -3 0.667
STK33STK33 0.693 -0.168 2 0.566
BIKEBIKE 0.692 -0.000 1 0.766
BLKBLK 0.691 -0.020 -1 0.751
YANK3YANK3 0.691 -0.060 2 0.359
ABL2ABL2 0.691 -0.092 -1 0.754
FYNFYN 0.691 0.016 -1 0.715
SRMSSRMS 0.691 -0.034 1 0.871
EPHA4EPHA4 0.690 -0.012 2 0.740
EPHB2EPHB2 0.689 -0.030 -1 0.780
FGRFGR 0.689 -0.098 1 0.872
RETRET 0.689 -0.143 1 0.783
LCKLCK 0.689 -0.059 -1 0.743
EPHB1EPHB1 0.688 -0.064 1 0.861
CSF1RCSF1R 0.688 -0.154 3 0.134
ROS1ROS1 0.687 -0.211 3 0.124
CRIKCRIK 0.687 -0.050 -3 0.663
TYK2TYK2 0.687 -0.195 1 0.783
HCKHCK 0.687 -0.100 -1 0.744
TYRO3TYRO3 0.687 -0.202 3 0.133
LIMK2_TYRLIMK2_TYR 0.686 -0.159 -3 0.822
ASK1ASK1 0.686 -0.139 1 0.740
JAK3JAK3 0.686 -0.115 1 0.775
ROCK1ROCK1 0.686 -0.071 -3 0.708
CK1G3CK1G3 0.686 0.002 -3 0.427
EPHB3EPHB3 0.685 -0.075 -1 0.777
DDR1DDR1 0.685 -0.135 4 0.772
LIMK1_TYRLIMK1_TYR 0.684 -0.198 2 0.821
HASPINHASPIN 0.684 -0.087 -1 0.644
JAK2JAK2 0.684 -0.205 1 0.775
FGFR2FGFR2 0.684 -0.107 3 0.162
ITKITK 0.684 -0.091 -1 0.723
PKG1PKG1 0.684 -0.081 -2 0.519
MST1RMST1R 0.684 -0.231 3 0.138
ABL1ABL1 0.684 -0.122 -1 0.745
KDRKDR 0.683 -0.135 3 0.128
KITKIT 0.683 -0.128 3 0.136
MYO3AMYO3A 0.682 -0.152 1 0.750
STLK3STLK3 0.682 -0.083 1 0.738
NEK3NEK3 0.682 -0.231 1 0.735
FLT3FLT3 0.682 -0.148 3 0.127
MERTKMERTK 0.681 -0.098 3 0.154
FLT1FLT1 0.681 -0.039 -1 0.806
TECTEC 0.681 -0.077 -1 0.676
TNK2TNK2 0.681 -0.159 3 0.128
EPHA5EPHA5 0.681 -0.021 2 0.733
METMET 0.680 -0.110 3 0.133
LYNLYN 0.680 -0.082 3 0.129
PDGFRBPDGFRB 0.680 -0.170 3 0.131
FGFR3FGFR3 0.679 -0.085 3 0.157
FGFR1FGFR1 0.679 -0.141 3 0.154
BMXBMX 0.679 -0.075 -1 0.656
TAO1TAO1 0.679 -0.162 1 0.701
INSRINSR 0.679 -0.111 3 0.131
NTRK1NTRK1 0.678 -0.114 -1 0.782
MYO3BMYO3B 0.678 -0.172 2 0.789
EPHA7EPHA7 0.678 -0.077 2 0.738
PTK2PTK2 0.677 0.028 -1 0.761
EGFREGFR 0.677 0.014 1 0.684
LTKLTK 0.676 -0.138 3 0.134
SRCSRC 0.676 -0.050 -1 0.712
ALKALK 0.676 -0.167 3 0.126
CK1G2CK1G2 0.676 -0.022 -3 0.514
EPHA3EPHA3 0.676 -0.083 2 0.715
SYKSYK 0.676 0.042 -1 0.743
ERBB2ERBB2 0.675 -0.102 1 0.763
TEKTEK 0.675 -0.197 3 0.130
NTRK2NTRK2 0.675 -0.141 3 0.135
NTRK3NTRK3 0.674 -0.095 -1 0.733
AXLAXL 0.673 -0.178 3 0.145
FLT4FLT4 0.673 -0.132 3 0.141
EPHA8EPHA8 0.673 -0.062 -1 0.746
NEK10_TYRNEK10_TYR 0.673 -0.097 1 0.643
AAK1AAK1 0.673 0.015 1 0.666
TNNI3K_TYRTNNI3K_TYR 0.673 -0.119 1 0.813
DDR2DDR2 0.673 -0.097 3 0.138
IGF1RIGF1R 0.672 -0.076 3 0.130
PTK2BPTK2B 0.672 -0.085 -1 0.710
FRKFRK 0.671 -0.125 -1 0.767
ERBB4ERBB4 0.671 -0.025 1 0.719
FGFR4FGFR4 0.671 -0.036 -1 0.734
JAK1JAK1 0.670 -0.182 1 0.722
BTKBTK 0.670 -0.178 -1 0.684
CSKCSK 0.669 -0.083 2 0.735
PTK6PTK6 0.669 -0.107 -1 0.657
TNK1TNK1 0.669 -0.205 3 0.133
MATKMATK 0.667 -0.096 -1 0.685
EPHA2EPHA2 0.665 -0.060 -1 0.739
EPHA1EPHA1 0.665 -0.185 3 0.124
WEE1_TYRWEE1_TYR 0.664 -0.147 -1 0.695
PDGFRAPDGFRA 0.664 -0.269 3 0.124
YANK2YANK2 0.662 -0.071 2 0.385
FESFES 0.650 -0.115 -1 0.635
ZAP70ZAP70 0.647 -0.045 -1 0.665
MUSKMUSK 0.647 -0.158 1 0.676