Motif 736 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1580 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8TX70 | COL6A5 | S2255 | ochoa | Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| O14715 | RGPD8 | S1579 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14920 | IKBKB | S689 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15400 | STX7 | S144 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O15504 | NUP42 | S82 | ochoa | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}. |
| O43683 | BUB1 | S411 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60271 | SPAG9 | S242 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60841 | EIF5B | S460 | ochoa | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}. |
| O75363 | BCAS1 | S381 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75460 | ERN1 | S724 | ochoa|psp | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:21317875, PubMed:24508390). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:21317875, PubMed:24508390). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:19328063, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:30118681, ECO:0000269|PubMed:36739529, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}. |
| O75899 | GABBR2 | S793 | ochoa | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}. |
| O94806 | PRKD3 | S442 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94953 | KDM4B | S1036 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95235 | KIF20A | S41 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95425 | SVIL | S296 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| P02545 | LMNA | S143 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P06753 | TPM3 | S207 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07951 | TPM2 | S206 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P10451 | SPP1 | S254 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11277 | SPTB | S2034 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P11940 | PABPC1 | S341 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P12883 | MYH7 | S1491 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13010 | XRCC5 | S318 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P13533 | MYH6 | S1493 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P14625 | HSP90B1 | S169 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P15260 | IFNGR1 | S306 | ochoa | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}. |
| P18583 | SON | S1670 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18669 | PGAM1 | S152 | ochoa | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}. |
| P21397 | MAOA | S383 | ochoa | Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) | Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity). {ECO:0000250|UniProtKB:P21396, ECO:0000269|PubMed:18391214, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:24169519, ECO:0000269|PubMed:8316221}. |
| P22059 | OSBP | S382 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22087 | FBL | S116 | ochoa | rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin) | S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930, PubMed:32017898). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P15646, ECO:0000269|PubMed:24352239, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:32017898, ECO:0000269|PubMed:34516797}. |
| P29374 | ARID4A | S673 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P35749 | MYH11 | S1189 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P38398 | BRCA1 | S1271 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42566 | EPS15 | S435 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46821 | MAP1B | S1171 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48047 | ATP5PO | S163 | ochoa | ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP synthase subunit O) (Oligomycin sensitivity conferral protein) (OSCP) | Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13621, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P49792 | RANBP2 | S2555 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49810 | PSEN2 | S22 | ochoa | Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:21285369}. |
| P50851 | LRBA | S1000 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P67936 | TPM4 | S170 | ochoa | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis. {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}. |
| Q00987 | MDM2 | S246 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q00987 | MDM2 | S253 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01082 | SPTBN1 | S2042 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02790 | FKBP4 | S258 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q02952 | AKAP12 | S645 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1256 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1324 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05513 | PRKCZ | S190 | ochoa | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q05682 | CALD1 | S219 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q07157 | TJP1 | S117 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08357 | SLC20A2 | S256 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q09666 | AHNAK | S856 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5752 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13153 | PAK1 | S149 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13310 | PABPC4 | S341 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13435 | SF3B2 | S357 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13470 | TNK1 | S505 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q13546 | RIPK1 | S161 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13557 | CAMK2D | S330 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13601 | KRR1 | S238 | ochoa | KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q14515 | SPARCL1 | S84 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
| Q15149 | PLEC | S754 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q16836 | HADH | S73 | ochoa | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| Q2M1Z3 | ARHGAP31 | S596 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q32MZ4 | LRRFIP1 | Y597 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q4VXU2 | PABPC1L | S341 | ochoa | Polyadenylate-binding protein 1-like (Embryonic poly(A)-binding protein) (Poly(A) binding protein cytoplasmic 1 like) | Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:37723834, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (By similarity). {ECO:0000250|UniProtKB:A2A5N3, ECO:0000269|PubMed:37052235, ECO:0000269|PubMed:37723834}. |
| Q53EZ4 | CEP55 | S215 | ochoa | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) | Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}. |
| Q5H9R7 | PPP6R3 | S817 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5QJE6 | DNTTIP2 | S175 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5UIP0 | RIF1 | S1384 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5UIP0 | RIF1 | S1576 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZL5 | ZMYM4 | S103 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q6FIF0 | ZFAND6 | S123 | ochoa | AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}. |
| Q70CQ2 | USP34 | S487 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q70Z53 | FRA10AC1 | S270 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q71F23 | CENPU | S97 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7L9L4 | MOB1B | S38 | ochoa | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Q7Z3J3 | RGPD4 | S1580 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6B7 | SRGAP1 | S407 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6E9 | RBBP6 | S979 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86X27 | RALGPS2 | S359 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q8IVF2 | AHNAK2 | S842 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1172 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1997 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2327 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2657 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4472 | ochoa | Protein AHNAK2 | None |
| Q8ND24 | RNF214 | S51 | ochoa | RING finger protein 214 | None |
| Q8TCN5 | ZNF507 | S404 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q96DX7 | TRIM44 | S323 | ochoa | Tripartite motif-containing protein 44 (Protein DIPB) | May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}. |
| Q96HH9 | GRAMD2B | S26 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96HY6 | DDRGK1 | S150 | ochoa | DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) | Component of the UFM1 ribosome E3 ligase (UREL) complex, a multiprotein complex that catalyzes ufmylation of endoplasmic reticulum-docked proteins (PubMed:30626644, PubMed:32160526, PubMed:35753586, PubMed:36121123, PubMed:36543799, PubMed:37595036, PubMed:37795761, PubMed:38383785, PubMed:38383789). The UREL complex plays a key role in ribosome recycling by mediating mono-ufmylation of the RPL26/uL24 subunit of the 60S ribosome following ribosome dissociation: ufmylation weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (PubMed:37595036, PubMed:38383785, PubMed:38383789). Within the UREL complex, DDRGK1 tethers the complex to the endoplasmic reticulum membrane to restrict its activity to endoplasmic reticulum-docked ribosomes and acts as an ufmylation 'reader': following RPL26/uL24 ufmylation, DDRGK1 specifically binds to ufmylated RPL26/uL24 via its UFIM motif, resulting in stable association between the 60S ribosome and the UREL complex, followed by dissociation of the 60S ribosome subunit from the endoplasmic reticulum membrane (PubMed:36121123, PubMed:37595036, PubMed:38383785, PubMed:38383789). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (PubMed:32160526, PubMed:36543799). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204, PubMed:32160526). Acts as a regulator of immunity by promoting differentiation of B-cells into plasma cells: acts by promoting expansion of the endoplasmic reticulum and regulating the unfolded protein response (UPR) (By similarity). May also be required for TRIP4 ufmylation (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). Required for stabilization and ufmylation of ATG9A (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:28263186, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:35753586, ECO:0000269|PubMed:36121123, ECO:0000269|PubMed:36543799, ECO:0000269|PubMed:37595036, ECO:0000269|PubMed:37795761, ECO:0000269|PubMed:38383785, ECO:0000269|PubMed:38383789}. |
| Q96T23 | RSF1 | S223 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99666 | RGPD5 | S1579 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BUH8 | BEGAIN | S197 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BUR5 | APOO | S44 | ochoa | MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:24743151, ECO:0000269|PubMed:25764979}. |
| Q9H361 | PABPC3 | S341 | ochoa | Polyadenylate-binding protein 3 (PABP-3) (Poly(A)-binding protein 3) (Testis-specific poly(A)-binding protein) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1. |
| Q9H8S9 | MOB1A | S38 | ochoa | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}. |
| Q9HC77 | CPAP | S265 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9HCK8 | CHD8 | S550 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NWC5 | TMEM45A | S256 | ochoa | Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7) | None |
| Q9P0K7 | RAI14 | S512 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0L2 | MARK1 | S463 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9UEY8 | ADD3 | S652 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UKY1 | ZHX1 | S202 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9UPW6 | SATB2 | S682 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9UQ35 | SRRM2 | S1258 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQM7 | CAMK2A | S330 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2D8 | SSX2IP | S452 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y3A5 | SBDS | S233 | ochoa | Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein) | Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269|PubMed:17643419, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:19759903, ECO:0000269|PubMed:21536732}. |
| Q9Y4B5 | MTCL1 | S1412 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4W2 | LAS1L | S545 | ochoa | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| P55060 | CSE1L | S342 | Sugiyama | Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}. |
| O14965 | AURKA | S104 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| O75582 | RPS6KA5 | S647 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Q8N129 | CNPY4 | S45 | Sugiyama | Protein canopy homolog 4 | Plays a role in the regulation of the cell surface expression of TLR4. {ECO:0000269|PubMed:16338228}. |
| P22061 | PCMT1 | S133 | Sugiyama | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250|UniProtKB:P23506, ECO:0000269|PubMed:3167043, ECO:0000269|PubMed:6469980}. |
| P22061 | PCMT1 | S132 | Sugiyama | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250|UniProtKB:P23506, ECO:0000269|PubMed:3167043, ECO:0000269|PubMed:6469980}. |
| Q14191 | WRN | S319 | EPSD|PSP | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| O76070 | SNCG | S51 | Sugiyama | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| Q9BYT3 | STK33 | S427 | Sugiyama | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q86UP3 | ZFHX4 | S319 | Sugiyama | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-445355 | Smooth Muscle Contraction | 0.000014 | 4.853 |
| R-HSA-397014 | Muscle contraction | 0.000155 | 3.810 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.000191 | 3.720 |
| R-HSA-390522 | Striated Muscle Contraction | 0.000378 | 3.422 |
| R-HSA-2028269 | Signaling by Hippo | 0.000875 | 3.058 |
| R-HSA-3371556 | Cellular response to heat stress | 0.000999 | 3.000 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.001569 | 2.804 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.001569 | 2.804 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.001585 | 2.800 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.001569 | 2.804 |
| R-HSA-1640170 | Cell Cycle | 0.001152 | 2.939 |
| R-HSA-9620244 | Long-term potentiation | 0.002318 | 2.635 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.002247 | 2.648 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.002105 | 2.677 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.002067 | 2.685 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.002928 | 2.533 |
| R-HSA-162582 | Signal Transduction | 0.002888 | 2.539 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.003254 | 2.488 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.004398 | 2.357 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.003801 | 2.420 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003916 | 2.407 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.004291 | 2.367 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.004398 | 2.357 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.004093 | 2.388 |
| R-HSA-111933 | Calmodulin induced events | 0.005755 | 2.240 |
| R-HSA-111997 | CaM pathway | 0.005755 | 2.240 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.006242 | 2.205 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.007126 | 2.147 |
| R-HSA-68886 | M Phase | 0.006835 | 2.165 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.008179 | 2.087 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.008179 | 2.087 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.008976 | 2.047 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.008479 | 2.072 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.009055 | 2.043 |
| R-HSA-111996 | Ca-dependent events | 0.008676 | 2.062 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.008214 | 2.085 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 0.010097 | 1.996 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 0.010097 | 1.996 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 0.010097 | 1.996 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.010149 | 1.994 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.011189 | 1.951 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.011189 | 1.951 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.010430 | 1.982 |
| R-HSA-75153 | Apoptotic execution phase | 0.010670 | 1.972 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.011759 | 1.930 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.014288 | 1.845 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 0.013522 | 1.869 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.014525 | 1.838 |
| R-HSA-68882 | Mitotic Anaphase | 0.014536 | 1.838 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.014616 | 1.835 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.016047 | 1.795 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.016047 | 1.795 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.014811 | 1.829 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.016506 | 1.782 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.016506 | 1.782 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.017379 | 1.760 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.017379 | 1.760 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.017071 | 1.768 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.017949 | 1.746 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.017949 | 1.746 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.018756 | 1.727 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.018756 | 1.727 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.018756 | 1.727 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.018756 | 1.727 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.018948 | 1.722 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.021643 | 1.665 |
| R-HSA-112043 | PLC beta mediated events | 0.020357 | 1.691 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.024658 | 1.608 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.024658 | 1.608 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 0.024658 | 1.608 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.023541 | 1.628 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.024658 | 1.608 |
| R-HSA-68875 | Mitotic Prophase | 0.026273 | 1.580 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.025361 | 1.596 |
| R-HSA-373760 | L1CAM interactions | 0.023863 | 1.622 |
| R-HSA-112040 | G-protein mediated events | 0.025229 | 1.598 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.026293 | 1.580 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.026898 | 1.570 |
| R-HSA-73886 | Chromosome Maintenance | 0.026898 | 1.570 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.032742 | 1.485 |
| R-HSA-5579012 | Defective MAOA causes BRUNS | 0.040760 | 1.390 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.048711 | 1.312 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.079870 | 1.098 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.079870 | 1.098 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.087500 | 1.058 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.095067 | 1.022 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.095067 | 1.022 |
| R-HSA-164843 | 2-LTR circle formation | 0.102572 | 0.989 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.027925 | 1.554 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.124718 | 0.904 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.031308 | 1.504 |
| R-HSA-8949613 | Cristae formation | 0.031308 | 1.504 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.034844 | 1.458 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.036667 | 1.436 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.038526 | 1.414 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.038526 | 1.414 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.146321 | 0.835 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.042350 | 1.373 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.042350 | 1.373 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.044313 | 1.353 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.048338 | 1.316 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.160429 | 0.795 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.160429 | 0.795 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.056766 | 1.246 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.058948 | 1.230 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.187953 | 0.726 |
| R-HSA-774815 | Nucleosome assembly | 0.072619 | 1.139 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.072619 | 1.139 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.063403 | 1.198 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.126831 | 0.897 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.172728 | 0.763 |
| R-HSA-3371568 | Attenuation phase | 0.058948 | 1.230 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.046309 | 1.334 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.050399 | 1.298 |
| R-HSA-191650 | Regulation of gap junction activity | 0.048711 | 1.312 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.124718 | 0.904 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 0.124718 | 0.904 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.146548 | 0.834 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.169781 | 0.770 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.042350 | 1.373 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.160429 | 0.795 |
| R-HSA-1221632 | Meiotic synapsis | 0.092233 | 1.035 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.074989 | 1.125 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.056766 | 1.246 |
| R-HSA-877300 | Interferon gamma signaling | 0.183650 | 0.736 |
| R-HSA-75893 | TNF signaling | 0.099945 | 1.000 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.044313 | 1.353 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.048711 | 1.312 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.056598 | 1.247 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.042350 | 1.373 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.061158 | 1.214 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.153404 | 0.814 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.153404 | 0.814 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.129607 | 0.887 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.072619 | 1.139 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.048711 | 1.312 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.064419 | 1.191 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.064419 | 1.191 |
| R-HSA-199920 | CREB phosphorylation | 0.072177 | 1.142 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.087500 | 1.058 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.095067 | 1.022 |
| R-HSA-379398 | Enzymatic degradation of Dopamine by monoamine oxidase | 0.095067 | 1.022 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.102572 | 0.989 |
| R-HSA-380612 | Metabolism of serotonin | 0.102572 | 0.989 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.117397 | 0.930 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.124718 | 0.904 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.031308 | 1.504 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.033057 | 1.481 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.146321 | 0.835 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.046309 | 1.334 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.052491 | 1.280 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.072619 | 1.139 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.107831 | 0.967 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.079870 | 1.098 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.174305 | 0.759 |
| R-HSA-141333 | Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB | 0.117397 | 0.930 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.044313 | 1.353 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.054613 | 1.263 |
| R-HSA-9766229 | Degradation of CDH1 | 0.082243 | 1.085 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.129607 | 0.887 |
| R-HSA-1500620 | Meiosis | 0.181620 | 0.741 |
| R-HSA-73887 | Death Receptor Signaling | 0.173360 | 0.761 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.087500 | 1.058 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 0.087500 | 1.058 |
| R-HSA-379401 | Dopamine clearance from the synaptic cleft | 0.146321 | 0.835 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 0.160429 | 0.795 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.107831 | 0.967 |
| R-HSA-191859 | snRNP Assembly | 0.107831 | 0.967 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.113177 | 0.946 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.178648 | 0.748 |
| R-HSA-68877 | Mitotic Prometaphase | 0.032849 | 1.483 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.140850 | 0.851 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.140850 | 0.851 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.082420 | 1.084 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.124718 | 0.904 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.046309 | 1.334 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.048338 | 1.316 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.082420 | 1.084 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.074839 | 1.126 |
| R-HSA-3928664 | Ephrin signaling | 0.174305 | 0.759 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.064419 | 1.191 |
| R-HSA-379397 | Enzymatic degradation of dopamine by COMT | 0.102572 | 0.989 |
| R-HSA-428540 | Activation of RAC1 | 0.117397 | 0.930 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.117397 | 0.930 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.124718 | 0.904 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.124718 | 0.904 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.124718 | 0.904 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.139180 | 0.856 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 0.146321 | 0.835 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.167396 | 0.776 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.058948 | 1.230 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.058948 | 1.230 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.061158 | 1.214 |
| R-HSA-140179 | Amine Oxidase reactions | 0.181157 | 0.742 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.102555 | 0.989 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.118591 | 0.926 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.149415 | 0.826 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.066398 | 1.178 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.146321 | 0.835 |
| R-HSA-162592 | Integration of provirus | 0.117397 | 0.930 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.069012 | 1.161 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.069012 | 1.161 |
| R-HSA-9675135 | Diseases of DNA repair | 0.074989 | 1.125 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.161242 | 0.793 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.095067 | 1.022 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.095067 | 1.022 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.146321 | 0.835 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.054613 | 1.263 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.074989 | 1.125 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.143693 | 0.843 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.043252 | 1.364 |
| R-HSA-450294 | MAP kinase activation | 0.113177 | 0.946 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.045346 | 1.343 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.046742 | 1.330 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.159249 | 0.798 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.035641 | 1.448 |
| R-HSA-448424 | Interleukin-17 signaling | 0.138019 | 0.860 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.064419 | 1.191 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.131979 | 0.879 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.167396 | 0.776 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.056766 | 1.246 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.193579 | 0.713 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.099144 | 1.004 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.067840 | 1.169 |
| R-HSA-5357801 | Programmed Cell Death | 0.119262 | 0.923 |
| R-HSA-913531 | Interferon Signaling | 0.122084 | 0.913 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.139180 | 0.856 |
| R-HSA-5676934 | Protein repair | 0.146321 | 0.835 |
| R-HSA-196783 | Coenzyme A biosynthesis | 0.160429 | 0.795 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.063397 | 1.198 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.187953 | 0.726 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.074989 | 1.125 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.074989 | 1.125 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.074989 | 1.125 |
| R-HSA-180786 | Extension of Telomeres | 0.107831 | 0.967 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.115876 | 0.936 |
| R-HSA-8939211 | ESR-mediated signaling | 0.167373 | 0.776 |
| R-HSA-70171 | Glycolysis | 0.066180 | 1.179 |
| R-HSA-216083 | Integrin cell surface interactions | 0.160993 | 0.793 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.146321 | 0.835 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.054126 | 1.267 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.051035 | 1.292 |
| R-HSA-112316 | Neuronal System | 0.114779 | 0.940 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.124718 | 0.904 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.124718 | 0.904 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.074989 | 1.125 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.110495 | 0.957 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.052554 | 1.279 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.149399 | 0.826 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.153192 | 0.815 |
| R-HSA-422475 | Axon guidance | 0.047629 | 1.322 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.087500 | 1.058 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.095067 | 1.022 |
| R-HSA-9842663 | Signaling by LTK | 0.124718 | 0.904 |
| R-HSA-70326 | Glucose metabolism | 0.096854 | 1.014 |
| R-HSA-373755 | Semaphorin interactions | 0.118591 | 0.926 |
| R-HSA-9675108 | Nervous system development | 0.065518 | 1.184 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.160429 | 0.795 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.181157 | 0.742 |
| R-HSA-445144 | Signal transduction by L1 | 0.187953 | 0.726 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.139180 | 0.856 |
| R-HSA-5673000 | RAF activation | 0.046309 | 1.334 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.174305 | 0.759 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.187953 | 0.726 |
| R-HSA-373753 | Nephrin family interactions | 0.187953 | 0.726 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.107831 | 0.967 |
| R-HSA-2262752 | Cellular responses to stress | 0.051305 | 1.290 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.042350 | 1.373 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.090317 | 1.044 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.033431 | 1.476 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.062035 | 1.207 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.152293 | 0.817 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.056766 | 1.246 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.135965 | 0.867 |
| R-HSA-5578775 | Ion homeostasis | 0.099945 | 1.000 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.121322 | 0.916 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.046309 | 1.334 |
| R-HSA-109581 | Apoptosis | 0.064314 | 1.192 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.181157 | 0.742 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.102555 | 0.989 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.089703 | 1.047 |
| R-HSA-162587 | HIV Life Cycle | 0.179514 | 0.746 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.045564 | 1.341 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.166842 | 0.778 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.087107 | 1.060 |
| R-HSA-9679506 | SARS-CoV Infections | 0.108817 | 0.963 |
| R-HSA-111885 | Opioid Signalling | 0.071899 | 1.143 |
| R-HSA-186797 | Signaling by PDGF | 0.115876 | 0.936 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.159678 | 0.797 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.173360 | 0.761 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.116615 | 0.933 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.124829 | 0.904 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.194693 | 0.711 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.194693 | 0.711 |
| R-HSA-198753 | ERK/MAPK targets | 0.194693 | 0.711 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.194693 | 0.711 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.194693 | 0.711 |
| R-HSA-5688426 | Deubiquitination | 0.197045 | 0.705 |
| R-HSA-5619102 | SLC transporter disorders | 0.200441 | 0.698 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.201378 | 0.696 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.202615 | 0.693 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.208007 | 0.682 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.208007 | 0.682 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.208971 | 0.680 |
| R-HSA-73894 | DNA Repair | 0.210894 | 0.676 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.211117 | 0.675 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.214582 | 0.668 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.214735 | 0.668 |
| R-HSA-1474290 | Collagen formation | 0.214735 | 0.668 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.215422 | 0.667 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.217776 | 0.662 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.217776 | 0.662 |
| R-HSA-429947 | Deadenylation of mRNA | 0.221102 | 0.655 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.221102 | 0.655 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.221102 | 0.655 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.221102 | 0.655 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.221102 | 0.655 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.223869 | 0.650 |
| R-HSA-157579 | Telomere Maintenance | 0.226921 | 0.644 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.227569 | 0.643 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.227569 | 0.643 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.227569 | 0.643 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.227569 | 0.643 |
| R-HSA-3214842 | HDMs demethylate histones | 0.227569 | 0.643 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.227569 | 0.643 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.229976 | 0.638 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.229976 | 0.638 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.229976 | 0.638 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.233034 | 0.633 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.233983 | 0.631 |
| R-HSA-3295583 | TRP channels | 0.233983 | 0.631 |
| R-HSA-525793 | Myogenesis | 0.233983 | 0.631 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.233983 | 0.631 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.233983 | 0.631 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.233983 | 0.631 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.233983 | 0.631 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.238850 | 0.622 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.240344 | 0.619 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.240344 | 0.619 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.240344 | 0.619 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.246652 | 0.608 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.246652 | 0.608 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.248256 | 0.605 |
| R-HSA-983712 | Ion channel transport | 0.250474 | 0.601 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.252908 | 0.597 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.252908 | 0.597 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.257145 | 0.590 |
| R-HSA-112311 | Neurotransmitter clearance | 0.259113 | 0.587 |
| R-HSA-211000 | Gene Silencing by RNA | 0.260639 | 0.584 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.263712 | 0.579 |
| R-HSA-182971 | EGFR downregulation | 0.265266 | 0.576 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.266785 | 0.574 |
| R-HSA-202403 | TCR signaling | 0.269858 | 0.569 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.271369 | 0.566 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.276002 | 0.559 |
| R-HSA-428157 | Sphingolipid metabolism | 0.277299 | 0.557 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.277422 | 0.557 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.277422 | 0.557 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.277422 | 0.557 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.279074 | 0.554 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.279549 | 0.554 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.281800 | 0.550 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.282145 | 0.550 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.282145 | 0.550 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.283424 | 0.548 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.283424 | 0.548 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.288283 | 0.540 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.289377 | 0.539 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.289377 | 0.539 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.291351 | 0.536 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.294416 | 0.531 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.294416 | 0.531 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.295281 | 0.530 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.295281 | 0.530 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.295281 | 0.530 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.295281 | 0.530 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.297480 | 0.527 |
| R-HSA-5693538 | Homology Directed Repair | 0.300542 | 0.522 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.301137 | 0.521 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.301137 | 0.521 |
| R-HSA-3371511 | HSF1 activation | 0.301137 | 0.521 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.301137 | 0.521 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.301137 | 0.521 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.303602 | 0.518 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.303602 | 0.518 |
| R-HSA-1500931 | Cell-Cell communication | 0.306683 | 0.513 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.306944 | 0.513 |
| R-HSA-419037 | NCAM1 interactions | 0.306944 | 0.513 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.306944 | 0.513 |
| R-HSA-8948216 | Collagen chain trimerization | 0.306944 | 0.513 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.312703 | 0.505 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.312703 | 0.505 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.312767 | 0.505 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.312767 | 0.505 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.315817 | 0.501 |
| R-HSA-69541 | Stabilization of p53 | 0.318415 | 0.497 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.318864 | 0.496 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.324079 | 0.489 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.324079 | 0.489 |
| R-HSA-5260271 | Diseases of Immune System | 0.324079 | 0.489 |
| R-HSA-202433 | Generation of second messenger molecules | 0.324079 | 0.489 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.324079 | 0.489 |
| R-HSA-194138 | Signaling by VEGF | 0.324948 | 0.488 |
| R-HSA-212436 | Generic Transcription Pathway | 0.329022 | 0.483 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.329697 | 0.482 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.329697 | 0.482 |
| R-HSA-69481 | G2/M Checkpoints | 0.331018 | 0.480 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.335268 | 0.475 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.335268 | 0.475 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.335268 | 0.475 |
| R-HSA-162906 | HIV Infection | 0.338424 | 0.471 |
| R-HSA-977444 | GABA B receptor activation | 0.340794 | 0.468 |
| R-HSA-991365 | Activation of GABAB receptors | 0.340794 | 0.468 |
| R-HSA-1474165 | Reproduction | 0.343113 | 0.465 |
| R-HSA-5576891 | Cardiac conduction | 0.346127 | 0.461 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.349136 | 0.457 |
| R-HSA-72312 | rRNA processing | 0.349761 | 0.456 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.351708 | 0.454 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.355559 | 0.449 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.362444 | 0.441 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.362444 | 0.441 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.367745 | 0.434 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.367745 | 0.434 |
| R-HSA-437239 | Recycling pathway of L1 | 0.367745 | 0.434 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.368757 | 0.433 |
| R-HSA-70263 | Gluconeogenesis | 0.373002 | 0.428 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.373002 | 0.428 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.378216 | 0.422 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.378216 | 0.422 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.378216 | 0.422 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.383624 | 0.416 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.384851 | 0.415 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.388516 | 0.411 |
| R-HSA-912446 | Meiotic recombination | 0.388516 | 0.411 |
| R-HSA-74160 | Gene expression (Transcription) | 0.390643 | 0.408 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.393602 | 0.405 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.393602 | 0.405 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.395104 | 0.403 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.398646 | 0.399 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.398646 | 0.399 |
| R-HSA-72649 | Translation initiation complex formation | 0.403648 | 0.394 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.408197 | 0.389 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.408609 | 0.389 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.408609 | 0.389 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.408609 | 0.389 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.413529 | 0.383 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.413529 | 0.383 |
| R-HSA-177929 | Signaling by EGFR | 0.413529 | 0.383 |
| R-HSA-8953854 | Metabolism of RNA | 0.420100 | 0.377 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.422572 | 0.374 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.423248 | 0.373 |
| R-HSA-1643685 | Disease | 0.423327 | 0.373 |
| R-HSA-597592 | Post-translational protein modification | 0.427216 | 0.369 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.427815 | 0.369 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.428047 | 0.369 |
| R-HSA-9033241 | Peroxisomal protein import | 0.428047 | 0.369 |
| R-HSA-9610379 | HCMV Late Events | 0.428272 | 0.368 |
| R-HSA-977443 | GABA receptor activation | 0.432807 | 0.364 |
| R-HSA-983189 | Kinesins | 0.432807 | 0.364 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.432807 | 0.364 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.432807 | 0.364 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.432807 | 0.364 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.432807 | 0.364 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.432807 | 0.364 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.436768 | 0.360 |
| R-HSA-1442490 | Collagen degradation | 0.437527 | 0.359 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.442208 | 0.354 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.446851 | 0.350 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.446851 | 0.350 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.446851 | 0.350 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.451455 | 0.345 |
| R-HSA-446728 | Cell junction organization | 0.452144 | 0.345 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.459839 | 0.337 |
| R-HSA-72306 | tRNA processing | 0.467325 | 0.330 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.469495 | 0.328 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.469495 | 0.328 |
| R-HSA-5218859 | Regulated Necrosis | 0.469495 | 0.328 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.469495 | 0.328 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.475489 | 0.323 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.475489 | 0.323 |
| R-HSA-418594 | G alpha (i) signalling events | 0.478209 | 0.320 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.478293 | 0.320 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.478293 | 0.320 |
| R-HSA-3000178 | ECM proteoglycans | 0.482637 | 0.316 |
| R-HSA-199991 | Membrane Trafficking | 0.484581 | 0.315 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.486946 | 0.313 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.486946 | 0.313 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.486946 | 0.313 |
| R-HSA-9824446 | Viral Infection Pathways | 0.487697 | 0.312 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.491219 | 0.309 |
| R-HSA-4086398 | Ca2+ pathway | 0.491219 | 0.309 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.491219 | 0.309 |
| R-HSA-168255 | Influenza Infection | 0.491591 | 0.308 |
| R-HSA-195721 | Signaling by WNT | 0.494710 | 0.306 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.495456 | 0.305 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.495456 | 0.305 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.495456 | 0.305 |
| R-HSA-380287 | Centrosome maturation | 0.499659 | 0.301 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.502154 | 0.299 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.503827 | 0.298 |
| R-HSA-69275 | G2/M Transition | 0.509984 | 0.292 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.515159 | 0.288 |
| R-HSA-9659379 | Sensory processing of sound | 0.516124 | 0.287 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.516124 | 0.287 |
| R-HSA-9833482 | PKR-mediated signaling | 0.520156 | 0.284 |
| R-HSA-6806834 | Signaling by MET | 0.520156 | 0.284 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.530469 | 0.275 |
| R-HSA-9609690 | HCMV Early Events | 0.535500 | 0.271 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.535500 | 0.271 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.538650 | 0.269 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.539591 | 0.268 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.539819 | 0.268 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.539819 | 0.268 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.552818 | 0.257 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.554973 | 0.256 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 0.554973 | 0.256 |
| R-HSA-72172 | mRNA Splicing | 0.557683 | 0.254 |
| R-HSA-392499 | Metabolism of proteins | 0.558180 | 0.253 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.558683 | 0.253 |
| R-HSA-1474244 | Extracellular matrix organization | 0.561173 | 0.251 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.562363 | 0.250 |
| R-HSA-202424 | Downstream TCR signaling | 0.562363 | 0.250 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.562363 | 0.250 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.569631 | 0.244 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.579110 | 0.237 |
| R-HSA-418990 | Adherens junctions interactions | 0.590686 | 0.229 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.590724 | 0.229 |
| R-HSA-1296071 | Potassium Channels | 0.590724 | 0.229 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.590724 | 0.229 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.594138 | 0.226 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.600882 | 0.221 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.607515 | 0.216 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.607515 | 0.216 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.608715 | 0.216 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.610790 | 0.214 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.617259 | 0.210 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.617259 | 0.210 |
| R-HSA-9833110 | RSV-host interactions | 0.620454 | 0.207 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.626141 | 0.203 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.626764 | 0.203 |
| R-HSA-449147 | Signaling by Interleukins | 0.627324 | 0.203 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.632970 | 0.199 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.632970 | 0.199 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.632970 | 0.199 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.632970 | 0.199 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.632970 | 0.199 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.639073 | 0.194 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.645076 | 0.190 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.645076 | 0.190 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.645076 | 0.190 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.656235 | 0.183 |
| R-HSA-4839726 | Chromatin organization | 0.657197 | 0.182 |
| R-HSA-9609646 | HCMV Infection | 0.659193 | 0.181 |
| R-HSA-421270 | Cell-cell junction organization | 0.661180 | 0.180 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.668111 | 0.175 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.670884 | 0.173 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.681748 | 0.166 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.697381 | 0.157 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.709824 | 0.149 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.716259 | 0.145 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.718287 | 0.144 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.721759 | 0.142 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.724086 | 0.140 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.733206 | 0.135 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.739849 | 0.131 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.742027 | 0.130 |
| R-HSA-166520 | Signaling by NTRKs | 0.750557 | 0.125 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.754717 | 0.122 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.756771 | 0.121 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.758808 | 0.120 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.758808 | 0.120 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.760511 | 0.119 |
| R-HSA-9609507 | Protein localization | 0.760828 | 0.119 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.762832 | 0.118 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.770679 | 0.113 |
| R-HSA-388396 | GPCR downstream signalling | 0.796011 | 0.099 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.801256 | 0.096 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.802923 | 0.095 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.802923 | 0.095 |
| R-HSA-2559583 | Cellular Senescence | 0.811052 | 0.091 |
| R-HSA-5617833 | Cilium Assembly | 0.826324 | 0.083 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.840370 | 0.076 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.844360 | 0.073 |
| R-HSA-1266738 | Developmental Biology | 0.847505 | 0.072 |
| R-HSA-5663205 | Infectious disease | 0.854585 | 0.068 |
| R-HSA-372790 | Signaling by GPCR | 0.860464 | 0.065 |
| R-HSA-8951664 | Neddylation | 0.867427 | 0.062 |
| R-HSA-8978868 | Fatty acid metabolism | 0.873940 | 0.059 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.877136 | 0.057 |
| R-HSA-168249 | Innate Immune System | 0.882057 | 0.055 |
| R-HSA-157118 | Signaling by NOTCH | 0.887097 | 0.052 |
| R-HSA-72766 | Translation | 0.891229 | 0.050 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.901394 | 0.045 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.907070 | 0.042 |
| R-HSA-168256 | Immune System | 0.908475 | 0.042 |
| R-HSA-6798695 | Neutrophil degranulation | 0.910074 | 0.041 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.910924 | 0.041 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.915340 | 0.038 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.918162 | 0.037 |
| R-HSA-382551 | Transport of small molecules | 0.924707 | 0.034 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.929153 | 0.032 |
| R-HSA-1483257 | Phospholipid metabolism | 0.929153 | 0.032 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.944150 | 0.025 |
| R-HSA-8957322 | Metabolism of steroids | 0.944623 | 0.025 |
| R-HSA-1280218 | Adaptive Immune System | 0.946647 | 0.024 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.952080 | 0.021 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.960606 | 0.017 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.968712 | 0.014 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.970528 | 0.013 |
| R-HSA-5668914 | Diseases of metabolism | 0.977197 | 0.010 |
| R-HSA-211859 | Biological oxidations | 0.989999 | 0.004 |
| R-HSA-109582 | Hemostasis | 0.991656 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.994342 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.996221 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 0.999982 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.818 | 0.116 | 2 | 0.751 |
FAM20C |
0.813 | 0.381 | 2 | 0.831 |
IKKB |
0.807 | 0.081 | -2 | 0.681 |
IKKA |
0.805 | 0.144 | -2 | 0.670 |
CDC7 |
0.804 | 0.069 | 1 | 0.783 |
PIM3 |
0.802 | 0.058 | -3 | 0.839 |
NDR2 |
0.802 | 0.034 | -3 | 0.855 |
CAMK2G |
0.801 | 0.121 | 2 | 0.727 |
CLK3 |
0.800 | 0.091 | 1 | 0.723 |
RSK2 |
0.799 | 0.096 | -3 | 0.757 |
GRK1 |
0.799 | 0.113 | -2 | 0.634 |
CAMK2B |
0.797 | 0.162 | 2 | 0.766 |
PRKD1 |
0.796 | 0.070 | -3 | 0.787 |
PRKD2 |
0.796 | 0.086 | -3 | 0.760 |
DSTYK |
0.795 | 0.050 | 2 | 0.773 |
PIM1 |
0.795 | 0.081 | -3 | 0.795 |
IKKE |
0.794 | 0.008 | 1 | 0.724 |
TBK1 |
0.794 | -0.011 | 1 | 0.730 |
PRPK |
0.794 | -0.044 | -1 | 0.810 |
RAF1 |
0.794 | -0.022 | 1 | 0.817 |
CAMK1B |
0.793 | 0.036 | -3 | 0.840 |
GRK6 |
0.793 | 0.152 | 1 | 0.788 |
P90RSK |
0.793 | 0.068 | -3 | 0.745 |
LATS2 |
0.793 | 0.043 | -5 | 0.621 |
CAMK2D |
0.793 | 0.100 | -3 | 0.804 |
SKMLCK |
0.792 | 0.053 | -2 | 0.648 |
RSK4 |
0.792 | 0.108 | -3 | 0.744 |
MOS |
0.792 | -0.020 | 1 | 0.796 |
PDHK4 |
0.791 | -0.016 | 1 | 0.814 |
MTOR |
0.791 | -0.044 | 1 | 0.748 |
PKN3 |
0.791 | 0.036 | -3 | 0.810 |
NDR1 |
0.790 | 0.004 | -3 | 0.836 |
ERK5 |
0.790 | 0.106 | 1 | 0.733 |
RSK3 |
0.790 | 0.048 | -3 | 0.747 |
MST4 |
0.789 | 0.010 | 2 | 0.740 |
CAMK2A |
0.789 | 0.110 | 2 | 0.732 |
ATR |
0.789 | 0.026 | 1 | 0.804 |
PKACG |
0.788 | 0.027 | -2 | 0.592 |
AURC |
0.788 | 0.033 | -2 | 0.511 |
MAPKAPK2 |
0.787 | 0.068 | -3 | 0.734 |
RIPK3 |
0.787 | -0.004 | 3 | 0.634 |
GCN2 |
0.787 | -0.172 | 2 | 0.656 |
LATS1 |
0.786 | 0.137 | -3 | 0.844 |
PRKX |
0.786 | 0.093 | -3 | 0.719 |
P70S6KB |
0.786 | 0.038 | -3 | 0.788 |
CHAK2 |
0.786 | 0.027 | -1 | 0.867 |
GRK5 |
0.786 | -0.048 | -3 | 0.867 |
NLK |
0.785 | -0.005 | 1 | 0.728 |
CDKL1 |
0.785 | 0.007 | -3 | 0.777 |
BMPR2 |
0.785 | -0.140 | -2 | 0.720 |
WNK1 |
0.784 | -0.005 | -2 | 0.666 |
ULK2 |
0.784 | -0.130 | 2 | 0.632 |
NIK |
0.783 | -0.021 | -3 | 0.863 |
AMPKA1 |
0.783 | 0.005 | -3 | 0.850 |
MARK4 |
0.783 | -0.001 | 4 | 0.826 |
MAPKAPK3 |
0.783 | 0.020 | -3 | 0.760 |
PKN2 |
0.782 | -0.012 | -3 | 0.836 |
PKCD |
0.782 | 0.001 | 2 | 0.650 |
NUAK2 |
0.782 | -0.025 | -3 | 0.833 |
PKACB |
0.782 | 0.046 | -2 | 0.527 |
MLK1 |
0.781 | -0.091 | 2 | 0.672 |
SRPK1 |
0.781 | 0.018 | -3 | 0.734 |
PDHK1 |
0.780 | -0.131 | 1 | 0.802 |
CAMLCK |
0.780 | -0.028 | -2 | 0.679 |
BMPR1B |
0.780 | 0.060 | 1 | 0.751 |
TGFBR2 |
0.780 | -0.102 | -2 | 0.645 |
GRK7 |
0.780 | 0.070 | 1 | 0.728 |
NEK6 |
0.780 | -0.102 | -2 | 0.697 |
AMPKA2 |
0.779 | 0.012 | -3 | 0.826 |
DLK |
0.779 | 0.003 | 1 | 0.808 |
HUNK |
0.779 | -0.101 | 2 | 0.640 |
PLK1 |
0.779 | 0.007 | -2 | 0.679 |
HIPK4 |
0.779 | -0.006 | 1 | 0.711 |
MSK1 |
0.779 | 0.041 | -3 | 0.738 |
NEK7 |
0.779 | -0.145 | -3 | 0.759 |
DAPK2 |
0.778 | -0.025 | -3 | 0.835 |
TSSK2 |
0.778 | -0.007 | -5 | 0.662 |
ATM |
0.778 | 0.030 | 1 | 0.755 |
MSK2 |
0.777 | -0.002 | -3 | 0.721 |
CAMK4 |
0.777 | -0.024 | -3 | 0.822 |
PLK3 |
0.777 | 0.056 | 2 | 0.666 |
DNAPK |
0.777 | 0.114 | 1 | 0.710 |
PAK1 |
0.777 | -0.019 | -2 | 0.591 |
TSSK1 |
0.776 | -0.003 | -3 | 0.863 |
GRK4 |
0.776 | -0.075 | -2 | 0.654 |
NIM1 |
0.776 | -0.041 | 3 | 0.657 |
NUAK1 |
0.776 | -0.002 | -3 | 0.789 |
PRKD3 |
0.776 | 0.026 | -3 | 0.725 |
CDKL5 |
0.776 | -0.009 | -3 | 0.762 |
ULK1 |
0.776 | -0.128 | -3 | 0.737 |
KIS |
0.775 | -0.045 | 1 | 0.564 |
RIPK1 |
0.775 | -0.050 | 1 | 0.812 |
PKR |
0.775 | 0.064 | 1 | 0.804 |
MELK |
0.775 | -0.004 | -3 | 0.797 |
AURB |
0.775 | -0.003 | -2 | 0.512 |
TGFBR1 |
0.775 | 0.021 | -2 | 0.644 |
WNK3 |
0.774 | -0.139 | 1 | 0.795 |
MLK2 |
0.774 | -0.096 | 2 | 0.676 |
MASTL |
0.774 | -0.172 | -2 | 0.659 |
BCKDK |
0.774 | -0.115 | -1 | 0.708 |
ICK |
0.773 | -0.028 | -3 | 0.802 |
MNK1 |
0.772 | 0.019 | -2 | 0.638 |
MNK2 |
0.772 | -0.010 | -2 | 0.618 |
NEK9 |
0.772 | -0.117 | 2 | 0.682 |
ALK2 |
0.771 | 0.044 | -2 | 0.667 |
TTBK2 |
0.771 | -0.115 | 2 | 0.553 |
SRPK2 |
0.771 | 0.008 | -3 | 0.663 |
MLK3 |
0.771 | -0.070 | 2 | 0.612 |
PKCB |
0.770 | -0.030 | 2 | 0.603 |
PKG2 |
0.770 | -0.000 | -2 | 0.540 |
MYLK4 |
0.770 | -0.008 | -2 | 0.606 |
PAK3 |
0.770 | -0.065 | -2 | 0.604 |
QSK |
0.770 | -0.015 | 4 | 0.793 |
ALK4 |
0.770 | -0.042 | -2 | 0.662 |
ACVR2B |
0.770 | 0.001 | -2 | 0.663 |
MARK3 |
0.769 | 0.016 | 4 | 0.769 |
CLK2 |
0.769 | 0.057 | -3 | 0.756 |
SGK3 |
0.769 | 0.015 | -3 | 0.765 |
AURA |
0.769 | -0.013 | -2 | 0.482 |
CHK1 |
0.769 | 0.015 | -3 | 0.826 |
PIM2 |
0.768 | 0.034 | -3 | 0.738 |
IRE1 |
0.768 | -0.107 | 1 | 0.781 |
ANKRD3 |
0.768 | -0.146 | 1 | 0.832 |
PKCA |
0.768 | -0.035 | 2 | 0.595 |
ACVR2A |
0.768 | -0.018 | -2 | 0.647 |
PAK6 |
0.767 | -0.002 | -2 | 0.570 |
PKCG |
0.767 | -0.054 | 2 | 0.593 |
SIK |
0.767 | -0.020 | -3 | 0.765 |
SMG1 |
0.767 | 0.010 | 1 | 0.765 |
BMPR1A |
0.767 | 0.044 | 1 | 0.724 |
QIK |
0.767 | -0.075 | -3 | 0.809 |
PASK |
0.766 | 0.101 | -3 | 0.844 |
CAMK1G |
0.766 | 0.003 | -3 | 0.743 |
PLK4 |
0.766 | -0.054 | 2 | 0.486 |
YSK4 |
0.766 | -0.093 | 1 | 0.774 |
PKACA |
0.766 | 0.026 | -2 | 0.494 |
PKCZ |
0.766 | -0.044 | 2 | 0.629 |
DRAK1 |
0.766 | -0.014 | 1 | 0.789 |
AKT2 |
0.766 | 0.021 | -3 | 0.685 |
MARK2 |
0.766 | 0.002 | 4 | 0.728 |
MLK4 |
0.766 | -0.082 | 2 | 0.597 |
BRSK1 |
0.766 | -0.039 | -3 | 0.786 |
SRPK3 |
0.765 | -0.019 | -3 | 0.713 |
CLK4 |
0.765 | -0.004 | -3 | 0.760 |
PHKG1 |
0.765 | -0.061 | -3 | 0.821 |
GRK2 |
0.765 | -0.023 | -2 | 0.588 |
DCAMKL1 |
0.764 | 0.010 | -3 | 0.793 |
PAK2 |
0.764 | -0.075 | -2 | 0.588 |
MEK1 |
0.764 | -0.115 | 2 | 0.699 |
MARK1 |
0.763 | -0.003 | 4 | 0.783 |
TLK2 |
0.763 | -0.082 | 1 | 0.792 |
CK2A2 |
0.762 | 0.100 | 1 | 0.653 |
PKCH |
0.762 | -0.062 | 2 | 0.573 |
CDK8 |
0.762 | -0.068 | 1 | 0.542 |
CHAK1 |
0.762 | -0.098 | 2 | 0.592 |
JNK2 |
0.762 | 0.020 | 1 | 0.488 |
IRE2 |
0.762 | -0.117 | 2 | 0.583 |
DYRK2 |
0.761 | -0.035 | 1 | 0.586 |
P70S6K |
0.761 | 0.011 | -3 | 0.690 |
CLK1 |
0.760 | -0.007 | -3 | 0.736 |
PLK2 |
0.760 | 0.089 | -3 | 0.755 |
AKT1 |
0.760 | 0.029 | -3 | 0.708 |
BRSK2 |
0.760 | -0.069 | -3 | 0.800 |
DCAMKL2 |
0.759 | 0.016 | -3 | 0.800 |
MAPKAPK5 |
0.759 | -0.047 | -3 | 0.670 |
CDK1 |
0.759 | -0.026 | 1 | 0.504 |
NEK2 |
0.759 | -0.124 | 2 | 0.654 |
CDK7 |
0.759 | -0.062 | 1 | 0.545 |
CAMKK1 |
0.758 | 0.137 | -2 | 0.779 |
VRK2 |
0.758 | -0.203 | 1 | 0.810 |
CAMK1D |
0.758 | 0.029 | -3 | 0.684 |
BRAF |
0.758 | -0.031 | -4 | 0.790 |
CDK18 |
0.757 | -0.034 | 1 | 0.472 |
JNK3 |
0.757 | -0.005 | 1 | 0.527 |
MEKK3 |
0.757 | -0.109 | 1 | 0.788 |
SSTK |
0.756 | -0.018 | 4 | 0.779 |
P38A |
0.756 | -0.024 | 1 | 0.592 |
CDK19 |
0.756 | -0.065 | 1 | 0.497 |
GSK3B |
0.756 | 0.056 | 4 | 0.519 |
IRAK4 |
0.755 | -0.051 | 1 | 0.790 |
GSK3A |
0.755 | 0.063 | 4 | 0.529 |
PHKG2 |
0.755 | -0.026 | -3 | 0.801 |
CK1E |
0.755 | -0.024 | -3 | 0.598 |
TAO3 |
0.755 | -0.042 | 1 | 0.778 |
CAMKK2 |
0.755 | 0.132 | -2 | 0.776 |
MST3 |
0.754 | -0.046 | 2 | 0.679 |
SNRK |
0.754 | -0.159 | 2 | 0.521 |
PERK |
0.754 | -0.151 | -2 | 0.714 |
CDK5 |
0.754 | -0.050 | 1 | 0.562 |
GAK |
0.754 | 0.057 | 1 | 0.778 |
P38B |
0.754 | -0.012 | 1 | 0.513 |
HIPK1 |
0.754 | -0.026 | 1 | 0.605 |
CK2A1 |
0.753 | 0.088 | 1 | 0.636 |
NEK5 |
0.753 | -0.084 | 1 | 0.814 |
ZAK |
0.753 | -0.120 | 1 | 0.773 |
GRK3 |
0.753 | -0.028 | -2 | 0.541 |
MEKK1 |
0.753 | -0.131 | 1 | 0.776 |
TTBK1 |
0.752 | -0.069 | 2 | 0.474 |
ERK1 |
0.752 | -0.043 | 1 | 0.505 |
HIPK2 |
0.752 | -0.032 | 1 | 0.494 |
SMMLCK |
0.752 | -0.045 | -3 | 0.794 |
PKCT |
0.752 | -0.068 | 2 | 0.587 |
ERK2 |
0.751 | -0.043 | 1 | 0.553 |
LKB1 |
0.751 | 0.089 | -3 | 0.765 |
MEK5 |
0.751 | -0.206 | 2 | 0.673 |
MEKK2 |
0.750 | -0.141 | 2 | 0.649 |
CDK13 |
0.750 | -0.083 | 1 | 0.516 |
DAPK3 |
0.750 | -0.001 | -3 | 0.799 |
CDK17 |
0.749 | -0.047 | 1 | 0.416 |
CDK2 |
0.749 | -0.057 | 1 | 0.588 |
WNK4 |
0.749 | -0.132 | -2 | 0.654 |
CK1G1 |
0.749 | -0.041 | -3 | 0.598 |
PKCI |
0.748 | -0.046 | 2 | 0.599 |
PAK5 |
0.748 | -0.051 | -2 | 0.492 |
MRCKA |
0.748 | 0.037 | -3 | 0.757 |
AKT3 |
0.748 | 0.020 | -3 | 0.622 |
P38G |
0.747 | -0.042 | 1 | 0.412 |
PINK1 |
0.747 | -0.144 | 1 | 0.765 |
CK1D |
0.747 | -0.013 | -3 | 0.552 |
SGK1 |
0.747 | 0.024 | -3 | 0.613 |
MPSK1 |
0.747 | -0.035 | 1 | 0.758 |
IRAK1 |
0.747 | -0.096 | -1 | 0.716 |
CDK9 |
0.746 | -0.082 | 1 | 0.526 |
TLK1 |
0.746 | -0.153 | -2 | 0.655 |
DYRK4 |
0.746 | -0.029 | 1 | 0.499 |
P38D |
0.746 | 0.011 | 1 | 0.432 |
GCK |
0.746 | -0.009 | 1 | 0.781 |
HRI |
0.745 | -0.222 | -2 | 0.696 |
PDK1 |
0.745 | -0.017 | 1 | 0.805 |
MRCKB |
0.745 | 0.017 | -3 | 0.745 |
NEK11 |
0.745 | -0.100 | 1 | 0.785 |
DYRK1A |
0.745 | -0.057 | 1 | 0.622 |
CDK16 |
0.745 | -0.022 | 1 | 0.433 |
PAK4 |
0.745 | -0.053 | -2 | 0.495 |
ROCK2 |
0.744 | 0.032 | -3 | 0.794 |
NEK8 |
0.744 | -0.109 | 2 | 0.649 |
DAPK1 |
0.744 | -0.009 | -3 | 0.780 |
CDK14 |
0.744 | -0.040 | 1 | 0.516 |
CK1A2 |
0.744 | -0.017 | -3 | 0.554 |
SLK |
0.744 | -0.024 | -2 | 0.601 |
PKCE |
0.744 | -0.033 | 2 | 0.574 |
CDK3 |
0.743 | -0.033 | 1 | 0.434 |
ERK7 |
0.743 | -0.013 | 2 | 0.458 |
CDK10 |
0.743 | -0.025 | 1 | 0.502 |
DYRK1B |
0.743 | -0.045 | 1 | 0.520 |
TAO2 |
0.742 | -0.102 | 2 | 0.703 |
PRP4 |
0.742 | -0.069 | -3 | 0.710 |
CAMK1A |
0.742 | -0.001 | -3 | 0.661 |
CDK12 |
0.741 | -0.090 | 1 | 0.490 |
DYRK3 |
0.740 | -0.048 | 1 | 0.613 |
LOK |
0.740 | -0.055 | -2 | 0.656 |
MST2 |
0.740 | -0.106 | 1 | 0.780 |
TAK1 |
0.740 | -0.039 | 1 | 0.828 |
PKN1 |
0.740 | -0.024 | -3 | 0.700 |
NEK4 |
0.739 | -0.067 | 1 | 0.777 |
MINK |
0.739 | -0.057 | 1 | 0.788 |
JNK1 |
0.738 | -0.007 | 1 | 0.470 |
HPK1 |
0.738 | -0.032 | 1 | 0.772 |
HIPK3 |
0.738 | -0.082 | 1 | 0.600 |
STK33 |
0.738 | -0.078 | 2 | 0.487 |
DMPK1 |
0.738 | 0.045 | -3 | 0.771 |
LRRK2 |
0.737 | -0.085 | 2 | 0.689 |
CHK2 |
0.737 | -0.015 | -3 | 0.631 |
CRIK |
0.736 | 0.042 | -3 | 0.700 |
BUB1 |
0.736 | 0.029 | -5 | 0.634 |
MAP3K15 |
0.736 | -0.096 | 1 | 0.765 |
TNIK |
0.736 | -0.075 | 3 | 0.671 |
MST1 |
0.735 | -0.084 | 1 | 0.774 |
NEK1 |
0.735 | -0.044 | 1 | 0.787 |
HGK |
0.734 | -0.097 | 3 | 0.682 |
KHS2 |
0.734 | -0.008 | 1 | 0.776 |
EEF2K |
0.734 | -0.106 | 3 | 0.663 |
SBK |
0.734 | 0.017 | -3 | 0.565 |
PDHK3_TYR |
0.733 | 0.190 | 4 | 0.892 |
KHS1 |
0.733 | -0.034 | 1 | 0.767 |
MAK |
0.732 | -0.004 | -2 | 0.570 |
YANK3 |
0.732 | -0.009 | 2 | 0.338 |
MOK |
0.730 | -0.001 | 1 | 0.644 |
ROCK1 |
0.730 | 0.003 | -3 | 0.759 |
MEKK6 |
0.729 | -0.161 | 1 | 0.771 |
PDHK4_TYR |
0.729 | 0.130 | 2 | 0.748 |
PKG1 |
0.728 | -0.049 | -2 | 0.466 |
PBK |
0.727 | -0.033 | 1 | 0.693 |
VRK1 |
0.727 | -0.193 | 2 | 0.656 |
RIPK2 |
0.725 | -0.178 | 1 | 0.752 |
YSK1 |
0.725 | -0.118 | 2 | 0.657 |
CDK6 |
0.724 | -0.069 | 1 | 0.494 |
CDK4 |
0.724 | -0.062 | 1 | 0.474 |
ALPHAK3 |
0.724 | 0.038 | -1 | 0.725 |
TESK1_TYR |
0.723 | -0.024 | 3 | 0.729 |
TTK |
0.722 | -0.095 | -2 | 0.661 |
MEK2 |
0.722 | -0.214 | 2 | 0.660 |
MAP2K6_TYR |
0.722 | 0.013 | -1 | 0.816 |
BMPR2_TYR |
0.721 | 0.048 | -1 | 0.799 |
OSR1 |
0.720 | -0.123 | 2 | 0.666 |
PDHK1_TYR |
0.719 | -0.011 | -1 | 0.836 |
MAP2K4_TYR |
0.718 | -0.062 | -1 | 0.811 |
MAP2K7_TYR |
0.718 | -0.140 | 2 | 0.709 |
PINK1_TYR |
0.717 | -0.107 | 1 | 0.809 |
NEK3 |
0.716 | -0.147 | 1 | 0.748 |
BIKE |
0.716 | -0.016 | 1 | 0.645 |
ASK1 |
0.715 | -0.099 | 1 | 0.754 |
LIMK2_TYR |
0.715 | -0.041 | -3 | 0.855 |
CK1A |
0.715 | -0.040 | -3 | 0.475 |
PKMYT1_TYR |
0.713 | -0.155 | 3 | 0.716 |
EPHA6 |
0.711 | -0.011 | -1 | 0.771 |
HASPIN |
0.711 | -0.067 | -1 | 0.701 |
RET |
0.711 | -0.109 | 1 | 0.780 |
TAO1 |
0.710 | -0.128 | 1 | 0.724 |
DDR1 |
0.710 | -0.048 | 4 | 0.810 |
MYO3B |
0.708 | -0.128 | 2 | 0.671 |
MYO3A |
0.707 | -0.143 | 1 | 0.755 |
TYK2 |
0.707 | -0.136 | 1 | 0.776 |
INSRR |
0.706 | -0.055 | 3 | 0.656 |
LIMK1_TYR |
0.706 | -0.186 | 2 | 0.699 |
CSF1R |
0.704 | -0.108 | 3 | 0.671 |
EPHB4 |
0.704 | -0.087 | -1 | 0.743 |
MST1R |
0.704 | -0.163 | 3 | 0.678 |
YANK2 |
0.704 | -0.017 | 2 | 0.360 |
JAK3 |
0.704 | -0.095 | 1 | 0.784 |
JAK2 |
0.703 | -0.130 | 1 | 0.768 |
ABL2 |
0.703 | -0.068 | -1 | 0.741 |
TYRO3 |
0.703 | -0.166 | 3 | 0.662 |
ROS1 |
0.703 | -0.158 | 3 | 0.643 |
EPHA4 |
0.703 | -0.014 | 2 | 0.674 |
FGR |
0.703 | -0.089 | 1 | 0.796 |
FER |
0.703 | -0.073 | 1 | 0.792 |
SRMS |
0.703 | -0.037 | 1 | 0.786 |
YES1 |
0.703 | -0.078 | -1 | 0.784 |
NEK10_TYR |
0.702 | -0.039 | 1 | 0.712 |
STLK3 |
0.701 | -0.161 | 1 | 0.741 |
TNK2 |
0.701 | -0.084 | 3 | 0.655 |
FGFR2 |
0.701 | -0.075 | 3 | 0.702 |
KIT |
0.700 | -0.100 | 3 | 0.681 |
CK1G3 |
0.699 | -0.025 | -3 | 0.437 |
AAK1 |
0.699 | 0.004 | 1 | 0.539 |
PDGFRB |
0.698 | -0.134 | 3 | 0.674 |
ABL1 |
0.698 | -0.083 | -1 | 0.733 |
TXK |
0.697 | -0.069 | 1 | 0.765 |
TNK1 |
0.697 | -0.108 | 3 | 0.649 |
FLT3 |
0.697 | -0.120 | 3 | 0.658 |
KDR |
0.696 | -0.127 | 3 | 0.647 |
EPHB1 |
0.696 | -0.095 | 1 | 0.787 |
HCK |
0.696 | -0.103 | -1 | 0.759 |
JAK1 |
0.695 | -0.084 | 1 | 0.738 |
AXL |
0.694 | -0.125 | 3 | 0.667 |
LCK |
0.694 | -0.091 | -1 | 0.767 |
ITK |
0.694 | -0.103 | -1 | 0.732 |
FGFR3 |
0.694 | -0.073 | 3 | 0.683 |
TEK |
0.693 | -0.128 | 3 | 0.640 |
MERTK |
0.693 | -0.116 | 3 | 0.663 |
DDR2 |
0.693 | -0.025 | 3 | 0.657 |
EPHB2 |
0.693 | -0.087 | -1 | 0.720 |
FGFR1 |
0.693 | -0.134 | 3 | 0.666 |
LTK |
0.693 | -0.096 | 3 | 0.648 |
EPHB3 |
0.693 | -0.113 | -1 | 0.723 |
FYN |
0.692 | -0.032 | -1 | 0.747 |
BLK |
0.692 | -0.074 | -1 | 0.770 |
NTRK1 |
0.691 | -0.113 | -1 | 0.727 |
EPHA3 |
0.691 | -0.071 | 2 | 0.639 |
MET |
0.690 | -0.141 | 3 | 0.666 |
BMX |
0.690 | -0.090 | -1 | 0.656 |
ALK |
0.690 | -0.131 | 3 | 0.631 |
FLT1 |
0.690 | -0.114 | -1 | 0.757 |
PDGFRA |
0.689 | -0.186 | 3 | 0.667 |
EPHA7 |
0.689 | -0.072 | 2 | 0.668 |
TEC |
0.688 | -0.124 | -1 | 0.670 |
ERBB2 |
0.687 | -0.128 | 1 | 0.733 |
BTK |
0.687 | -0.143 | -1 | 0.706 |
INSR |
0.687 | -0.114 | 3 | 0.625 |
FLT4 |
0.687 | -0.134 | 3 | 0.651 |
TNNI3K_TYR |
0.687 | -0.142 | 1 | 0.763 |
PTK2B |
0.686 | -0.060 | -1 | 0.702 |
WEE1_TYR |
0.686 | -0.135 | -1 | 0.714 |
EPHA5 |
0.686 | -0.053 | 2 | 0.668 |
LYN |
0.686 | -0.085 | 3 | 0.608 |
NTRK2 |
0.685 | -0.151 | 3 | 0.644 |
PTK6 |
0.684 | -0.184 | -1 | 0.669 |
FGFR4 |
0.684 | -0.049 | -1 | 0.694 |
EGFR |
0.684 | -0.054 | 1 | 0.644 |
PTK2 |
0.683 | -0.014 | -1 | 0.692 |
NTRK3 |
0.683 | -0.122 | -1 | 0.681 |
MATK |
0.682 | -0.113 | -1 | 0.691 |
CK1G2 |
0.682 | -0.040 | -3 | 0.525 |
EPHA1 |
0.681 | -0.156 | 3 | 0.651 |
CSK |
0.681 | -0.109 | 2 | 0.655 |
SRC |
0.680 | -0.091 | -1 | 0.741 |
EPHA8 |
0.680 | -0.089 | -1 | 0.718 |
FRK |
0.679 | -0.158 | -1 | 0.773 |
SYK |
0.678 | -0.029 | -1 | 0.696 |
IGF1R |
0.674 | -0.106 | 3 | 0.587 |
EPHA2 |
0.672 | -0.080 | -1 | 0.675 |
ERBB4 |
0.671 | -0.061 | 1 | 0.641 |
MUSK |
0.664 | -0.162 | 1 | 0.646 |
FES |
0.658 | -0.118 | -1 | 0.633 |
ZAP70 |
0.655 | -0.089 | -1 | 0.626 |